CN105147583A - Special camellia-saponin-contained toothpaste for child and preparation method thereof - Google Patents
Special camellia-saponin-contained toothpaste for child and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses special camellia-saponin-contained toothpaste for a child and a preparation method thereof. The toothpaste is prepared from, by weight, 5-8 parts of camellia cakes or degreased camellia seeds, 1-3 parts of gleditsia sinensis, 0.5-2 parts of camellia oil, 1-3 parts of moyeam tea, 0.5-1 part of rosmarinus officinalis, 1-3 parts of hypericum perforatum, 0.5-1 part of fructus momordicae, 10-15 parts of watermelon seeds, 10-15 parts of egg shells, 1-3 parts of indigo naturalis, 0.5-1 part of citric acid, 0.5-1 part of sodium citrate, 0.5-1 part of CMC and 20-35 parts of deionized water. The camellia, the gleditsia sinensis, the moyeam tea and other natural plants are used as components to prepare the special toothpaste for the child, the toothpaste has good cleaning and whitening effects and a good protecting effect on teeth of the child, can prevent the problem that because the child likes to eat sweet foods, tooth decay is likely to be generated and effectively reduces dental plaque and other common oral cavity problems, the fragrance and effect components can prevent halitosis, and dental ulcer and pharyngitis can be reduced.
Description
Technical field
The invention belongs to cosmetics of everyday use preparing technical field, be specifically related to a kind of children special-purpose toothpaste containing Sasanguasaponin and preparation method thereof.
Background technology
Toothpaste is a kind of indispensable articles for daily use, not only has well clean whitening function to tooth, protects the health of one's teeth in addition, ensures the effects such as oral hygiene, and What is more can the emotion of mediator, affects the health of human body.At present, the toothpaste that China domestic market is sold is main mainly with adult's toothpaste, the product being exclusively used in children's toothpaste is less, and the effect that most of children's toothpaste mainly relies on fluoride to reach mothproof, but fluorine element enters in human body by oral mucosa, can cause occurring dental fluorosis, even occurring the diseases such as osteofluorosis.Therefore, oral cavity, various countries expert does not advise that child uses toothpaste with fluoride, in order to avoid child is in the process of brushing teeth, owing to swallowing toothpaste unconsciously or adhesive sticker of gargling after brushing teeth, makes fluorine residue cause disease in oral cavity.
Summary of the invention
The object of the present invention is to provide a kind of children special-purpose toothpaste containing Sasanguasaponin and preparation method thereof, it uses natural plants as primary raw material, the obtained children special-purpose toothpaste containing Sasanguasaponin has well clean whitening and protective effect to teenager teeth, the problem that child is easily decayed tooth because of sweet tooth can be prevented, effective control oral cavity bacterium growth, reduce dental plaque, gingiva problem and dentine hypersensitivity, the common oral problems such as dental calculus, and its fragrance and effect component not only can keep the pure and fresh of oral cavity, also depressive emotion can be reduced, oral ulcer, the generation of pharyngolaryngitis etc.
For achieving the above object, the technical solution used in the present invention is:
Containing the children special-purpose toothpaste of Sasanguasaponin, it is raw materials used comprises by weight: Oil-tea-cake or defat camellia oleosa seed 5-8 part, Fructus Gleditsia 1-3 part, wild Oleum Camelliae 0.5-2 part, Ampelopsis grossedentata 1-3 part, Herba Rosmarini Officinalis 0.5-1 part, Herba Hyperici perforati 1-3 part, Fructus Momordicae 0.5-1 part, watermelon seeds 10-15 part, Ovum crusta Gallus domesticus 10-15 part, Indigo Naturalis 1-3 part, citric acid 0.5-1 part, sodium citrate 0.5-1 part, CMC0.5-1 part, deionized water 20-35 part.
The preparation method of the described children special-purpose toothpaste containing Sasanguasaponin comprises the following steps:
1) Oil-tea-cake or defat camellia oleosa seed, Fructus Gleditsia are crushed to 10 ~ 20 orders jointly, then in more than 95 DEG C lixiviates twice, first time adds flooding 35min by solid-liquid ratio 1:25, second time adds flooding 20min by solid-liquid ratio 1:15, then two-stage leaching liquid is merged, reach 30Brix-35Brix through disk centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain component A;
2) by Ampelopsis grossedentata, Herba Rosmarini Officinalis, Indigo Naturalis mixing, to add water at 100 DEG C supersound extraction 30min by solid-liquid ratio 1:28, supersonic frequency is 40-80kHZ, and then after filtration, centrifugal, the ultrafiltration of tubular type, the reverse osmosis concentrated soluble solid content that is reduced to reach 25Brix-35Brix, obtains B component;
3) by after watermelon seeds, the abundant drying of Ovum crusta Gallus domesticus, adopting ball mill to be crushed to granularity is 500 ~ 800 orders, obtains component C;
4) wild Oleum Camelliae and CMC are mixed to obtain component D;
5) Herba Hyperici perforati is pressed solid-liquid ratio 1:10 lixiviate 20min with the water of 80 DEG C, abandon its leachate, residue is at 75 DEG C, the alcohol steep 1.5h that mass fraction is 80% is added by solid-liquid ratio 1:25, filter while hot, filtrate obtains component E after reclaiming ethanol with rotary evaporation;
6) Fructus Momordicae is carried out skin breaking, at 95-100 DEG C, add flooding 1.5h by solid-liquid ratio 1:32, filter, filtering residue adds flooding 0.5h by solid-liquid ratio 1:16 again, merging filtrate, ultrafiltration centrifugal through tubular type, is concentrated into soluble solid content and reaches 30Brix, obtains component F;
7) B component, E, F are added in component A be heated to 45 DEG C, then add component D mixing gradually and carry out emulsifying, to be placed in colloid mill and to add component C and fully stir evenly, regulate its pH value to 7.2-7.6 with citric acid and sodium citrate again, and add deionized water and make the viscosity of mastic at 13kPas, mastic is carried out vacuum outgas, tinning under-0.085 ~-0.090Mpa pressure, obtained finished product.
The present invention using the saponin that extracts from Semen Camelliae, Fructus Gleditsia as surfactant and emulsifying agent, using wild Oleum Camelliae as wetting agent, antioxidant, using the extractum of Fructus Momordicae as the sweeting agent of toothpaste, be equipped with Ampelopsis grossedentata, Herba Rosmarini Officinalis, the botanical extract such as Indigo Naturalis, Herba Hyperici perforati, prepare a kind of tooth paste product being exclusively used in child.The effects such as this toothpaste has outstanding cleaning teeth, protection oral cavity, anti-halitosis, prevention is depressed, effectively can control oral cavity bacterium growth, reduce dental plaque, gingiva problem and the common oral such as dentine hypersensitivity, dental calculus problem.Wherein, wild Oleum Camelliae contains the compositions such as higher unsaturated fatty acid, Squalene, VE, has good moisturizing and antioxidation, can make oral cavity and lip can not be too dry; Sasanguasaponin in oil tea, HLB value is 16, there are good emulsifying, dirt-removing power, and have good bacteriostasis, physical property surfactant is planted with the use of both producing certain foam with Fructus Gleditsia saponin two kinds, there is again well pure white and antibacterial action, the halitosis that can effectively prevent the excessive breeding of bacterial fungus from being formed or dental plaque; Ampelopsis grossedentata contains abundant dihydromyricetin, can be good at antibacterial, antiinflammatory, elimination free radical, thus plays the gingiva that takes care of one's teeth, the in advance anti-halitosis and effect such as decayed tooth, anti-dental calculus; Herba Hyperici perforati contains composition---hypericin that is abundant, that can prevent depressive emotion, is applied in toothpaste, and the effect preventing depressive emotion is played in the absorption by oral epithelium to child; Main component indirubin, couroupitine A etc. in Indigo Naturalis have very strong bacteriostasis, the more important thing is, its can heat clearing away, removing heat from blood, prevention and therapy oral ulcer and gingiva pain, this not only has good protective effect to toothpaste itself, and decays tooth can play an important role for control child; The sweet taste of Fructus Momordicae be the 100-300 of sweetness of cane sugar doubly, be a kind of natural safe sweeting agent, it contains abundant aminoacid and vitamin simultaneously, use in toothpaste can nutrition oral cavity, gingiva, throat inflammation can also be prevented; Herba Rosmarini Officinalis fragrance conclusive effect is played for the odor type of toothpaste, also have very strong bacteriostasis simultaneously, well can prevent halitosis, keep the health in oral cavity; CMC and sodium carboxymethyl cellulose, it has the preferably important function such as short changes, thickening, retentiveness, can make toothpaste not easily solid-liquid separation also can keep certain shape.
remarkable advantage of the present invention is:the present invention containing Sasanguasaponin children special-purpose toothpaste by various plants extract and natural component formulated, have well clean, whitening function to the tooth of child, particularly it can prevent decayed tooth, can prevent the problem that child is easily decayed tooth because of sweet tooth.Children special-purpose toothpaste of the present invention does not have zest to oral epithelium, effective control oral cavity bacterium growth, minimizing dental plaque, gingiva problem and the common oral such as dentine hypersensitivity, dental calculus problem, the fragrance of its fragrance and constituent part, bacteriostasis can play and prevent the effect such as halitosis, pleasant mood, and to oral cavity, there is moisture-keeping function, zest is little, safety is high, by force functional, be very applicable to child use.
Detailed description of the invention
More being convenient to make content of the present invention understand, below in conjunction with detailed description of the invention, technical solutions according to the invention are described further, but the present invention being not limited only to this.
embodiment 1
Containing the children special-purpose toothpaste of Sasanguasaponin, it is raw materials used comprises by weight: Oil-tea-cake 5 parts, Fructus Gleditsia 1 part, wild Oleum Camelliae 0.5 part, Ampelopsis grossedentata 1 part, Herba Rosmarini Officinalis 0.5 part, Herba Hyperici perforati 1 part, Fructus Momordicae 0.5 part, watermelon seeds 10 parts, Ovum crusta Gallus domesticus 10 parts, Indigo Naturalis 1 part, citric acid 0.5 part, sodium citrate 0.5 part, CMC0.5 part, deionized water 20 parts.
The preparation method of the described children special-purpose toothpaste containing Sasanguasaponin comprises the following steps:
1) Oil-tea-cake, Fructus Gleditsia are crushed to 10 orders jointly, then in more than 95 DEG C lixiviates twice, first time adds flooding 35min by solid-liquid ratio 1:25, second time adds flooding 20min by solid-liquid ratio 1:15, then two-stage leaching liquid is merged, reach 30Brix through disk centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain component A;
2) by Ampelopsis grossedentata, Herba Rosmarini Officinalis, Indigo Naturalis mixing, to add water at 100 DEG C supersound extraction 30min by solid-liquid ratio 1:28, supersonic frequency is 40-80kHZ, and then after filtration, centrifugal, the ultrafiltration of tubular type, the reverse osmosis concentrated soluble solid content that is reduced to reach 25Brix, obtains B component;
3) by after watermelon seeds, the abundant drying of Ovum crusta Gallus domesticus, adopting ball mill to be crushed to granularity is 500 orders, obtains component C;
4) wild Oleum Camelliae and CMC are mixed to obtain component D;
5) Herba Hyperici perforati is pressed solid-liquid ratio 1:10 lixiviate 20min with the water of 80 DEG C, abandon its leachate, residue is at 75 DEG C, the alcohol steep 1.5h that mass fraction is 80% is added by solid-liquid ratio 1:25, filter while hot, filtrate obtains component E after reclaiming ethanol with rotary evaporation;
6) Fructus Momordicae is carried out skin breaking, at 95 DEG C, add flooding 1.5h by solid-liquid ratio 1:32, filter, filtering residue adds flooding 0.5h by solid-liquid ratio 1:16 again, merging filtrate, ultrafiltration centrifugal through tubular type, is concentrated into soluble solid content and reaches 30Brix, obtains component F;
7) B component, E, F are added in component A be heated to 45 DEG C, then add component D mixing gradually and carry out emulsifying, to be placed in colloid mill and to add component C and fully stir evenly, its pH value to 7.2 is regulated again with citric acid and sodium citrate, and add deionized water and make the viscosity of mastic at 13kPas, mastic is carried out vacuum outgas, tinning under the pressure being greater than-0.094Mpa, obtained finished product.
embodiment 2
Containing the children special-purpose toothpaste of Sasanguasaponin, it is raw materials used comprises by weight: defat camellia oleosa seed 6 parts, Fructus Gleditsia 2 parts, wild Oleum Camelliae 1.0 parts, Ampelopsis grossedentata 2 parts, Herba Rosmarini Officinalis 0.8 part, Herba Hyperici perforati 2 parts, Fructus Momordicae 0.8 part, watermelon seeds 12 parts, Ovum crusta Gallus domesticus 13 parts, Indigo Naturalis 2 parts, citric acid 0.8 part, sodium citrate 0.8 part, CMC0.6 part, deionized water 28 parts.
The preparation method of the described children special-purpose toothpaste containing Sasanguasaponin comprises the following steps:
1) defat camellia oleosa seed, Fructus Gleditsia are crushed to 10 orders jointly, then in more than 95 DEG C lixiviates twice, first time adds flooding 35min by solid-liquid ratio 1:25, second time adds flooding 20min by solid-liquid ratio 1:15, then two-stage leaching liquid is merged, reach 30Brix through disk centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain component A;
2) by Ampelopsis grossedentata, Herba Rosmarini Officinalis, Indigo Naturalis mixing, to add water at 100 DEG C supersound extraction 30min by solid-liquid ratio 1:28, supersonic frequency is 40-80kHZ, and then after filtration, centrifugal, the ultrafiltration of tubular type, the reverse osmosis concentrated soluble solid content that is reduced to reach 35Brix, obtains B component;
3) by after watermelon seeds, the abundant drying of Ovum crusta Gallus domesticus, adopting ball mill to be crushed to granularity is 600 orders, obtains component C;
4) wild Oleum Camelliae and CMC are mixed to obtain component D;
5) Herba Hyperici perforati is pressed solid-liquid ratio 1:10 lixiviate 20min with the water of 80 DEG C, abandon its leachate, residue is at 75 DEG C, the alcohol steep 1.5h that mass fraction is 80% is added by solid-liquid ratio 1:25, filter while hot, filtrate obtains component E after reclaiming ethanol with rotary evaporation;
6) Fructus Momordicae is carried out skin breaking, at 97 DEG C, add flooding 1.5h by solid-liquid ratio 1:32, filter, filtering residue adds flooding 0.5h by solid-liquid ratio 1:16 again, merging filtrate, ultrafiltration centrifugal through tubular type, is concentrated into soluble solid content and reaches 30Brix, obtains component F;
7) B component, E, F are added in component A be heated to 45 DEG C, then add component D mixing gradually and carry out emulsifying, to be placed in colloid mill and to add component C and fully stir evenly, its pH value to 7.5 is regulated again with citric acid and sodium citrate, and add deionized water and make the viscosity of mastic at 13kPas, mastic is carried out vacuum outgas, tinning under the pressure being greater than-0.094Mpa, obtained finished product.
embodiment 3
Containing the children special-purpose toothpaste of Sasanguasaponin, it is raw materials used comprises by weight: Oil-tea-cake 8 parts, Fructus Gleditsia 3 parts, wild Oleum Camelliae 2 parts, Ampelopsis grossedentata 3 parts, Herba Rosmarini Officinalis 1 part, Herba Hyperici perforati 3 parts, Fructus Momordicae 1 part, watermelon seeds 15 parts, Ovum crusta Gallus domesticus 15 parts, Indigo Naturalis 3 parts, citric acid 1 part, sodium citrate 1 part, CMC1 part, deionized water 35 parts.
The preparation method of the described children special-purpose toothpaste containing Sasanguasaponin comprises the following steps:
1) Oil-tea-cake, Fructus Gleditsia are crushed to 20 orders jointly, then in more than 95 DEG C lixiviates twice, first time adds flooding 35min by solid-liquid ratio 1:25, second time adds flooding 20min by solid-liquid ratio 1:15, then two-stage leaching liquid is merged, reach 35Brix through disk centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain component A;
2) by Ampelopsis grossedentata, Herba Rosmarini Officinalis, Indigo Naturalis mixing, to add water at 100 DEG C supersound extraction 30min by solid-liquid ratio 1:28, supersonic frequency is 40-80kHZ, and then after filtration, centrifugal, the ultrafiltration of tubular type, the reverse osmosis concentrated soluble solid content that is reduced to reach 35Brix, obtains B component;
3) by after watermelon seeds, the abundant drying of Ovum crusta Gallus domesticus, adopting ball mill to be crushed to granularity is 800 orders, obtains component C;
4) wild Oleum Camelliae and CMC are mixed to obtain component D;
5) Herba Hyperici perforati is pressed solid-liquid ratio 1:10 lixiviate 20min with the water of 80 DEG C, abandon its leachate, residue is at 75 DEG C, the alcohol steep 1.5h that mass fraction is 80% is added by solid-liquid ratio 1:25, filter while hot, filtrate obtains component E after reclaiming ethanol with rotary evaporation;
6) Fructus Momordicae is carried out skin breaking, at 100 DEG C, add flooding 1.5h by solid-liquid ratio 1:32, filter, filtering residue adds flooding 0.5h by solid-liquid ratio 1:16 again, merging filtrate, ultrafiltration centrifugal through tubular type, is concentrated into soluble solid content and reaches 30Brix, obtains component F;
7) B component, E, F are added in component A be heated to 45 DEG C, then add component D mixing gradually and carry out emulsifying, to be placed in colloid mill and to add component C and fully stir evenly, its pH value to 7.6 is regulated again with citric acid and sodium citrate, and add deionized water and make the viscosity of mastic at 13kPas, mastic is carried out vacuum outgas, tinning under the pressure being greater than-0.094Mpa, obtained finished product.
performance test
1, organoleptic attribute: toothpaste prepared by embodiment 1-3 is clean, evenly, fine and smooth, color and luster is normal, with dense Herba Rosmarini Officinalis fragrance.
2, physical and chemical index: toothpaste denseness prepared by embodiment 1-3 is between 12 ~ 25, squeeze cream pressure and be less than 40kPa, foam volume moderate (about 60mm), mastic can not overflow automatically, can not separate out water, has good stability.
3, toothpaste primary efficacy clinical trial
The child of private kindergartens all in pilot region is carried out respectively to the investigation of decayed tooth situation, find that its child's decayed tooth rate is all within the scope of 5.7%-8.3%.Consistent four private kindergartens of selection scale are as subjects, be denoted as school 1, school 2, school 3, school 4, to school 2 and school 3 child everyone distribute four bottles of children special-purpose toothpaste of the present invention, require respectively to use once in time sooner or later brushing teeth, and exhort that the head of a family coordinates supervision service condition simultaneously, other 2 learning handed down in a family correct the commercially available children's toothpaste of normal use, again carry out the investigation of decayed tooth situation, the results are shown in Table 1 after half a year.
Table 1 child uses the decayed tooth rate result of the test of toothpaste
Show from table 1 result, do not use the child of the Liang Ge school of toothpaste of the present invention, its decayed tooth rate has increasing to a certain degree, and uses the decayed tooth rate of the Liang Ge school of toothpaste of the present invention constant, even there is certain reduction, illustrate that children's toothpaste of the present invention has significant effect for control decayed tooth.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (8)
1. containing the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: raw materials usedly to comprise by weight: Oil-tea-cake or defat camellia oleosa seed 5-8 part, Fructus Gleditsia 1-3 part, wild Oleum Camelliae 0.5-2 part, Ampelopsis grossedentata 1-3 part, Herba Rosmarini Officinalis 0.5-1 part, Herba Hyperici perforati 1-3 part, Fructus Momordicae 0.5-1 part, watermelon seeds 10-15 part, Ovum crusta Gallus domesticus 10-15 part, Indigo Naturalis 1-3 part, citric acid 0.5-1 part, sodium citrate 0.5-1 part, CMC0.5-1 part, deionized water 20-35 part.
2., as claimed in claim 1 containing a preparation method for the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: comprise the following steps:
1) Oil-tea-cake or defat camellia oleosa seed, Fructus Gleditsia are crushed to 10 ~ 20 orders jointly, then reach 30Brix-35Brix through lixiviate, centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain component A;
2) by Ampelopsis grossedentata, Herba Rosmarini Officinalis, Indigo Naturalis mixing, reach 25Brix-35Brix through supersound extraction, filtration, centrifugal, ultrafiltration, the reverse osmosis concentrated soluble solid content that is reduced to, obtain B component;
3) by after watermelon seeds, the abundant drying of Ovum crusta Gallus domesticus, adopt ball mill to pulverize, obtain component C;
4) wild Oleum Camelliae and CMC are mixed to obtain component D;
5) Herba Hyperici perforati is once abandoned its leachate with hot water extraction, residue ethanol extraction, filtrate obtains component E after reclaiming ethanol with rotary evaporation;
6) Fructus Momordicae is carried out skin breaking, lixiviate twice, merging filtrate, through centrifugal, ultrafiltration, be concentrated into soluble solid content and reach 30Brix, obtain component F;
7) B component, E, F are added in component A be heated to 45 DEG C, then add component D mixing gradually and carry out emulsifying, to be placed in colloid mill and to add component C and fully stir evenly, regulate its pH value to 7.2-7.6 with citric acid and sodium citrate again, and add deionized water and make the viscosity of mastic at 13kPas, mastic is carried out vacuum outgas, tinning, obtained finished product.
3. according to claim 2 containing the preparation method of the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: lixiviate described in step 1) is specifically in more than 95 DEG C lixiviates twice, first time adds flooding 35min by solid-liquid ratio 1:25, second time adds flooding 20min by solid-liquid ratio 1:15, is then merged by two-stage leaching liquid.
4., according to claim 2 containing the preparation method of children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: step 2) described supersound extraction to add water supersound extraction 30min by solid-liquid ratio 1:28 at 100 DEG C, supersonic frequency is 40-80kHZ.
5., according to claim 2 containing the preparation method of the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: being crushed to granularity in step 3) is 500 ~ 800 orders.
6. according to claim 2 containing the preparation method of children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: hot water extraction described in step 5) is by solid-liquid ratio 1:10 lixiviate 20min by the Herba Hyperici perforati water of 80 DEG C;
Described ethanol extraction be by hot water extraction after residue at 75 DEG C, add by solid-liquid ratio 1:25 the alcohol steep 1.5h that mass fraction is 80%, filter while hot.
7. according to claim 2 containing the preparation method of the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: in step 6), twice lixiviate adds flooding 1.5h by solid-liquid ratio 1:32 at 95-100 DEG C, filter, filtering residue adds flooding 0.5h by solid-liquid ratio 1:16 again.
8., according to claim 2 containing the preparation method of the children special-purpose toothpaste of Sasanguasaponin, it is characterized in that: in step 7), the pressure of vacuum outgas is-0.085 ~-0.090MPa.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106420552A (en) * | 2016-08-31 | 2017-02-22 | 福建省梦娇兰日用化学品有限公司 | Special toothpaste containing multiple components from natural sources for children |
| CN106727024A (en) * | 2017-01-13 | 2017-05-31 | 华南理工大学 | A kind of oil tea gargle and preparation method thereof |
| CN109157421A (en) * | 2018-08-03 | 2019-01-08 | 李守林 | Green and healthy toothpaste cream of microvesicle washing function and the preparation method and application thereof |
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| CN106420552A (en) * | 2016-08-31 | 2017-02-22 | 福建省梦娇兰日用化学品有限公司 | Special toothpaste containing multiple components from natural sources for children |
| CN106727024A (en) * | 2017-01-13 | 2017-05-31 | 华南理工大学 | A kind of oil tea gargle and preparation method thereof |
| CN109157421A (en) * | 2018-08-03 | 2019-01-08 | 李守林 | Green and healthy toothpaste cream of microvesicle washing function and the preparation method and application thereof |
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| Publication number | Publication date |
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| CN105147583B (en) | 2018-01-02 |
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