CN104825368A - Natural plant active toothpaste and preparation method thereof - Google Patents
Natural plant active toothpaste and preparation method thereof Download PDFInfo
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- CN104825368A CN104825368A CN201510270296.3A CN201510270296A CN104825368A CN 104825368 A CN104825368 A CN 104825368A CN 201510270296 A CN201510270296 A CN 201510270296A CN 104825368 A CN104825368 A CN 104825368A
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Abstract
The invention provides natural plant active toothpaste and a preparation method thereof. The natural plant active toothpaste is composed of the following components in percentage by mass: 2-3% of a saponin extract, 2-3% of a soapberry extract, 2-3% of tea seed saponetin, 3-5% of neem oil, 9-15% of camellia chekiang-oleosa hu fruit oil, 0.5-1% of Yunnan melia azedarach antibacterial preservative, 0.5-1% of a mangosteen antioxidant preservative, 1-1.5% of tea flavours, 0.5-1% of gleditsia sinensis fruit gum, 0.5-1% of a sealwort extract, 0.3-0.5% of panax notoginseng saponins, 0.1% of papain, 15-20% of a corn extract, 0.3-0.5% of a Yunnan mint extract, 22-25% of water, 15-40% of calcium hydrogen phosphate dehydrate and 1-5% of dicalicium phosphate anhydrous. The toothpaste has the functions of repairing oral damaged mucosa, diminishing inflammation, relieving pain, stopping bleeding, whitening, and refreshing breath, and has a remarkable effect on common oral diseases. After use, the toothpaste is moderate and fine in texture, good in taste, lasting in fragrance, high in antibacterial action, good in absorption effect, and capable of whitening teeth and protecting teeth in case of being used for a long time.
Description
Technical field
The invention belongs to technical field of toothpaste, be specially a kind of natural plant active toothpaste and preparation method thereof.
Background technology
Brushing teeth is the work that people must complete in daily life every day, can clean and take care of one's teeth, preventing and treating odontopathy, be of value to body and mind and dental health by brushing teeth.The use of toothpaste just becomes indispensable oral cavity cleaning and health hygienic articles for use in people's daily life.The toothpaste of brushing teeth used effect that is different, that play will be different.The toothpaste variety sold in the market is various, as having " YUNNAN BAIYAO " toothpaste of anastalsis, " Luclean " and " six must control " toothpaste of control hemodia, for " Colgate-Palmolive " and " Crest " whitening toothpaste etc. brightened, although these have different purposes and effect, but effect and performance single, while playing antiinflammatory, pain relieving, anastalsis, often also can not have the effect of whitening, and action time is also lasting not.
In recent years, along with the continuous enhancing of consumer healthcare's consciousness, propose more and more higher requirement to toothpaste, people no longer content just to have cleaning and health care effect, and need the toothpaste simultaneously with good auxiliary therapeutic action to come out.Because natural plant active component has good therapeutical effect, and natural environmental-protective, side effect are little, meet people and pursue nature and healthy consumption concept.Therefore, the research that natural plants and extract thereof join in formulation of tooth-paste be have also been obtained fast development.Though some toothpaste sold in the market is containing plant component, but single medicinal material often, and producing process is more complicated, therapeutical effect is single, therefore need to develop on the basis of existing technology and there is multi-functional, plurality kinds of health care and therapeutical effect, there is the toothpaste of whitening function simultaneously, to meet the needs of people to oral cavity health and therapeutical effect.
Summary of the invention
In view of the above-mentioned problems in the prior art, the object of the present invention is to provide and a kind ofly have the natural plant active toothpaste and preparation method thereof repairing impaired mucosa, antiinflammatory, pain relieving, hemostasis, pure white, fresh breath effect, this toothpaste has significant curative effect to common oral disease.
The present invention is realized by following technical proposal: a kind of natural plant active toothpaste, is made up of the component of following masses percentage composition:
Fructus Gleditsiae Abnormalis extract 2 ~ 3%, soapberry extract 2 ~ 3%,
Thea saponin 2 ~ 3%, neem oil 3 ~ 5%,
Safflower oil tea fruit oil 9 ~ 15%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5 ~ 1%,
Cortex Garciniae antioxidation antifungus agent 0.5 ~ 1%, Folium Camelliae sinensis spice 1 ~ 1.5%,
Fructus Gleditsia rice glue 0.5 ~ 1%, Rhizoma Polygonati extract 0.5 ~ 1%,
Radix Notoginseng total arasaponins 0.3 ~ 0.5%, carase 0.1%,
Corn extract 15 ~ 20%, Yunnan Folium Menthae extract 0.3 ~ 0.5%,
Pure water 22 ~ 25%, calcium phosphate dibasic dihydrate 15 ~ 40%,
Calcium phosphate dibasic anhydrous 1 ~ 5%,
The summation of said components is 100%.
Described Fructus Gleditsiae Abnormalis extract is commercial products or obtains through the following step:
(1) spaonin powder of drying is broken to particle diameter and is less than 5mm;
(2) in the spaonin powder of step (1), add deionized water by the mass ratio of 1:4 ~ 6, soak 18 ~ 24 hours at 40 ~ 60 DEG C, and stirring obtains mixed material;
(3) filtered by step (2) gained mixed material, filtrate boils 5 ~ 10 minutes, then adds the kieselguhr of 0.1 ~ 3%, stirs 30 ~ 50 minutes, refilter and obtain Fructus Gleditsiae Abnormalis extract at 40 ~ 50 DEG C.
Described soapberry extract and Rhizoma Polygonati extract are commercial products or obtain through the following step:
A, the peel of Fructus Sapindi Mukouossi getting drying or Rhizoma Polygonati, grind to 100 ~ 200 orders, obtain raw material powder;
B, in the raw material powder of steps A, by the mass ratio of 1:2 ~ 3 add mass concentration be 60 ~ 80% ethanol water extract 2 ~ 3 times, filter to get filtrate and filtering residue;
C, filtering residue is carried out soxhlet type, extraction solvent is acetone and ethyl acetate mixed solvent, and temperature is 60 ~ 80 DEG C, and the time is 1 ~ 2 hour, then leaves standstill, and filters and obtains extract;
D, the filtrate of combining step B and the extract of step C, revolve and steam except desolventizing, obtain sticky shape paste, be soapberry extract or Rhizoma Polygonati extract.
Described Yunnan Melia azedarach L. bacteriostatic preservative and Cortex Garciniae antioxidation antifungus agent are commercial products or obtain through the following step:
1. Yunnan Melia azedarach L. or Cortex Garciniae dried in the shade, pulverize, enucleation, obtain 80 ~ 120 object powder stocks;
2. in step powder stock 1., add the ethanol of 70 ~ 95%, its liquid ratio counts the volume ratio L/L of 5:1, supersound extraction 50 ~ 100min is carried out under ultrasonic power 500 ~ 800W, repeat extraction 3 ~ 4 times, merging filtrate, filtrate is carried out reduction vaporization at 25 ~ 30 DEG C, obtains Yunnan Extractives From Melia Azedarach L or garcinia mangostana extractive;
3. HPD-400 type macroporous adsorbent resin soak with ethanol 24h is carried out remove impurity, activation, step Yunnan Extractives From Melia Azedarach L 2. or garcinia mangostana extractive distilled water are dissolved, and to be made into relative density be 1.02 ~ 1.20g/cm
3solution, after solution is filtered, get the upper macroporous adsorbent resin of filtrate, controlling applied sample amount is 4 ~ 5g/mL resin, and adsorption rate is 0.5 ~ 0.6mL/min, use distilled water, 30% ethanol remove impurity more successively, remove impurity speed 0.8 ~ 1mL/min, collects ethanol elution, elution speed 1.5 ~ 2.0mL/min, eluent room temperature concentrating under reduced pressure at 25 ~ 35 DEG C is dry, namely obtains Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent.
Described Fructus Gleditsia rice glue is commercial products or obtains through the following step:
A, by saponin rice pulverizing to 400 ~ 600 order, the pure water then adding 30 ~ 90% of saponin rice quality stirs, then leaves standstill 1 ~ 3h and make it expand;
B, step a gained mixture is slowly heated to 60 ~ 80 DEG C, and Keep agitation 20 ~ 30min is to the pasty state being dissolved into thickness completely, is then cooled to room temperature, namely obtains Fructus Gleditsia rice glue.
Described thea saponin, neem oil, safflower oil tea fruit oil, Folium Camelliae sinensis spice, Radix Notoginseng total arasaponins, carase, corn extract, Yunnan Folium Menthae extract, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous are commercial products.
Another object of the present invention is to a kind of preparation method of natural plant active toothpaste, pass through each step:
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 2 ~ 3%, soapberry extract 2 ~ 3%,
Thea saponin 2 ~ 3%, neem oil 3 ~ 5%,
Safflower oil tea fruit oil 9 ~ 15%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5 ~ 1%,
Cortex Garciniae antioxidation antifungus agent 0.5 ~ 1%, Folium Camelliae sinensis spice 1 ~ 1.5%,
Fructus Gleditsia rice glue 0.5 ~ 1%, Rhizoma Polygonati extract 0.5 ~ 1%,
Radix Notoginseng total arasaponins 0.3 ~ 0.5%, carase 0.1%,
Corn extract 15 ~ 20%, Yunnan Folium Menthae extract 0.3 ~ 0.5%,
Pure water 22 ~ 25%, calcium phosphate dibasic dihydrate 15 ~ 40%,
Calcium phosphate dibasic anhydrous 1 ~ 5%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, namely obtain natural plant active toothpaste.
The present invention is pure vegetable active toothpaste, wherein Fructus Gleditsiae Abnormalis extract, soapberry extract and thea saponin are as foaming agent, neem oil, safflower oil tea fruit oil is wetting agent, Yunnan Melia azedarach L. bacteriostatic preservative, Cortex Garciniae antioxidation antifungus agent and carase are the antiseptic and antibiotic agent of natural anti-oxidation, Folium Camelliae sinensis spice and Yunnan Folium Menthae extract are as essence, Fructus Gleditsia rice glue and Rhizoma Polygonati extract are as thickening agent, calcium phosphate dibasic dihydrate and calcium phosphate dibasic anhydrous are as abrasive, and Radix Notoginseng total arasaponins and corn extract are antiinflammatory, hemostatic function thing.
Wherein, Fructus Gleditsia: nature and flavor: sweetness and bitterness is flat; Gui Jing: lung, large intestine channel; Effect: expelling phlegm for arresting cough, have one's ideas straightened out logical to close, parasite killing eliminating stagnation.Fructus Sapindi Mukouossi: nature and flavor: bitter is flat; Function: heat clearing away, eliminates the phlegm, removing food stagnancy, parasite killing.Thea saponin is a kind of natural nonionic surfactant of function admirable, and it has foaming, emulsifying, dispersion, the performance such as gentle, and has the pharmacological action of the aspects such as impervious, antiinflammatory, analgesia.Neem oil has anticorrosion and bactericidal action, can treat urine imbalance, bronchitis, septicemia, diarrhoea, fever, erythra, scald, knife injury, hypertension, jaundice, wound infection, leprosy, dermatosis, gastric ulcer and chickenpox etc.The unsaturated fatty acids content of safflower oil tea fruit oil is greater than 88%, and be rich in necessary 17 seed amino acids of human body and zinc, selenium and other trace elements, its quality exceedes west first Fructus oleae europaeae oil, has effects such as reducing cardiovascular and cerebrovascular disease, blood fat-reducing blood pressure-decreasing, defying age, life lengthening.Yunnan Melia azedarach L.: bitter in the mouth, cold in nature, has clearing heat and expelling damp, parasite killing, antipruritic effect.Cortex Garciniae: nature and flavor: bitter, puckery, cool, function: anti-inflammatory analgetic, convergence granulation promoting.Folium Camelliae sinensis spice not only has the effect adding perfume, also having calm effect.Saponin rice rich in nutrition content, nutrient categories is more, belongs to high-energy, Hi CHO, low albumen, low fat food, can be in harmonious proportion human-body viscera function, having nourishes heart promotes blood circulation, liver heat removing and eyesight improving, nourishing spleen and kidney, relieving cough and asthma, eliminates the phlegm and has one's ideas straightened out, loosening bowel to relieve constipation, skin moistening skin care, beneficial smart diuresis, effects such as QI invigorating of refreshing oneself.Rhizoma Polygonati: nature and flavor: sweet, property is put down; Energy nourishing kidney lung moistening, invigorating the spleen and replenishing QI, has anti-hypoxia, resisting fatigue, anti-aging effects; Can immunologic function be strengthened, strengthen metabolism; There are blood sugar lowering and cardiotonic.Radix Notoginseng total arasaponins is the active active ingredient that Radix Notoginseng is extracted; There is blood circulation promoting and blood stasis dispelling, active effect of promoting blood circulation, can anticoagulant and increase cerebral blood flow.
Carase not only has antioxidation, antiseptical effect, when also mixing with protein and oils and fats, has unique whitening, moistens, the effect such as speckle dispelling dirt, blood circulation promoting.Corn extract has the effect such as antitumor, anti-inflammatory.Effect of the existing refrigerant fragrance of Folium Menthae extract, has again the magical effect of sterilizing.
The advantage that the present invention possesses and effect: present invention utilizes the active ingredient of natural plants as functional component, also adopt natural extract as each component of toothpaste matrix simultaneously, there is the effect of repairing oral cavity impaired mucosa, antiinflammatory, pain relieving, hemostasis, pure white, fresh breath, have remarkable result to common oral disease.After using this toothpaste, not only quality is gentle fine and smooth, and mouthfeel is good, lasting fragrance, and bacteriostasis is strong, good absorbing effect, life-time service energy functions of whitening teeth, takes care of one's teeth.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 2%, soapberry extract 2%,
Thea saponin 2%, neem oil 3%,
Safflower oil tea fruit oil 10%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5%,
Cortex Garciniae antioxidation antifungus agent 0.8%, Folium Camelliae sinensis spice 1%,
Fructus Gleditsia rice glue 0.5%, Rhizoma Polygonati extract 0.5%,
Radix Notoginseng total arasaponins 0.3%, carase 0.1%,
Corn extract 15%, Yunnan Folium Menthae extract 0.3%,
Pure water 22%, calcium phosphate dibasic dihydrate 38%,
Calcium phosphate dibasic anhydrous 2%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, namely obtain natural plant active toothpaste.
Wherein, described Fructus Gleditsiae Abnormalis extract, soapberry extract, Rhizoma Polygonati extract, Yunnan Melia azedarach L. bacteriostatic preservative, Cortex Garciniae antioxidation antifungus agent, Fructus Gleditsia rice glue, thea saponin, neem oil, safflower oil tea fruit oil, Folium Camelliae sinensis spice, Radix Notoginseng total arasaponins, carase, corn extract, Yunnan Folium Menthae extract, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous are commercial products.
Embodiment 2
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 3%, soapberry extract 2.4%,
Thea saponin 3%, neem oil 5%,
Safflower oil tea fruit oil 15%, Yunnan Melia azedarach L. bacteriostatic preservative 1%,
Cortex Garciniae antioxidation antifungus agent 1%, Folium Camelliae sinensis spice 1.5%,
Fructus Gleditsia rice glue 1%, Rhizoma Polygonati extract 1%,
Radix Notoginseng total arasaponins 0.5%, carase 0.1%,
Corn extract 20%, Yunnan Folium Menthae extract 0.5%,
Pure water 25%, calcium phosphate dibasic dihydrate 15%,
Calcium phosphate dibasic anhydrous 5%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, namely obtain natural plant active toothpaste.
Wherein, described Fructus Gleditsiae Abnormalis extract is commercial products or obtains through the following step:
(1) spaonin powder of drying is broken to particle diameter and is less than 5mm;
(2) spaonin powder of 1 part of quality is minced and to soak 20 hours at 60 DEG C with the deionized water of 5 parts of quality, and stir and obtain mixed material;
(3) filtered by step (2) gained mixed material, filtrate boils 10 minutes, then adds the kieselguhr of 1%, stirs 50 minutes, refilter and obtain Fructus Gleditsiae Abnormalis extract at 50 DEG C.
Described soapberry extract or Rhizoma Polygonati extract are commercial products or obtain through the following step:
A, the Fructus Sapindi Mukouossi fruit of getting drying or Rhizoma Polygonati, ground, obtained 200 object material powders;
B, mass percent concentration material powder being added 3 parts of quality are extract 2 times in the ethanol water of 70%, then filter, obtain filtrate and filtering residue;
C, filtering residue is carried out soxhlet type, extraction solvent is acetone and ethyl acetate mixed solvent, and temperature is 80 DEG C, and the time is 1 hour, then leaves standstill, and filters and obtains extract;
D, the filtrate of combining step B and the extract of step C, revolve and steam except desolventizing, obtain sticky shape paste, be soapberry extract or Rhizoma Polygonati extract.
Described Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent are commercial products or obtain through the following step:
1. Yunnan Melia azedarach L. or Cortex Garciniae dried in the shade, pulverize, enucleation, obtain 80 object powder stocks;
2. in step powder stock 1., add the ethanol of 95%, its liquid ratio L/L counts 5:1, under ultrasonic power 700W, carry out supersound extraction 80min, repeat extraction 3 times, merging filtrate, carries out reduction vaporization by filtrate at 30 DEG C, obtains Yunnan Extractives From Melia Azedarach L or garcinia mangostana extractive;
3. HPD-400 type macroporous adsorbent resin soak with ethanol 24h is carried out remove impurity, activation, step Yunnan Extractives From Melia Azedarach L 2. or garcinia mangostana extractive distilled water are dissolved, and to be made into relative density be 1.20g/cm
3solution, after solution is filtered, get the upper macroporous adsorbent resin of filtrate, controlling applied sample amount is 4g/mL resin, and adsorption rate is 0.6mL/min, use distilled water, 30% ethanol remove impurity more successively, remove impurity speed 0.8mL/min, collects ethanol elution, elution speed 2.0mL/min, eluent room temperature concentrating under reduced pressure at 30 DEG C is dry, namely obtains Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent.
Described Fructus Gleditsia rice glue is commercial products or obtains through the following step:
A, by saponin rice pulverizing to 500 order, the pure water then adding saponin rice quality 60% stirs, then leaves standstill 2h and make it expand;
B, step a gained mixture is slowly heated to 80 DEG C, and Keep agitation 20min is to the pasty state being dissolved into thickness completely, is then cooled to room temperature, namely obtains Fructus Gleditsia rice glue.
Described thea saponin, neem oil, safflower oil tea fruit oil, Folium Camelliae sinensis spice, Radix Notoginseng total arasaponins, carase, corn extract, Yunnan Folium Menthae extract, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous are commercial products.
Embodiment 3
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 2.5%, soapberry extract 3%,
Thea saponin 2.5%, neem oil 4%,
Safflower oil tea fruit oil 12%, Yunnan Melia azedarach L. bacteriostatic preservative 0.8%,
Cortex Garciniae antioxidation antifungus agent 0.5%, Folium Camelliae sinensis spice 1.2%,
Fructus Gleditsia rice glue 0.8%, Rhizoma Polygonati extract 0.8%,
Radix Notoginseng total arasaponins 0.4%, carase 0.1%,
Corn extract 18%, Yunnan Folium Menthae extract 0.4%,
Pure water 23%, calcium phosphate dibasic dihydrate 29%,
Calcium phosphate dibasic anhydrous 1%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, namely obtain natural plant active toothpaste.
Wherein, described Fructus Gleditsiae Abnormalis extract is commercial products or obtains through the following step:
(1) spaonin powder of drying is broken to particle diameter and is less than 5mm;
(2) spaonin powder of 1 part of quality is minced and to soak 18 hours at 50 DEG C with the deionized water of 6 parts of quality, and stir and obtain mixed material;
(3) filtered by step (2) gained mixed material, filtrate boils 6 minutes, then adds the kieselguhr of 3%, stirs 35 minutes, refilter and obtain Fructus Gleditsiae Abnormalis extract at 45 DEG C.
Described soapberry extract or Rhizoma Polygonati extract are commercial products or obtain through the following step:
A, the Fructus Sapindi Mukouossi fruit of getting drying or Rhizoma Polygonati, ground, obtained 150 object material powders;
B, mass percent concentration material powder being added 3 parts of quality are extract 3 times in the ethanol water of 80%, then filter, obtain filtrate and filtering residue;
C, filtering residue is carried out soxhlet type, extraction solvent is acetone and ethyl acetate mixed solvent, and temperature is 60 DEG C, and the time is 2 hours, then leaves standstill, and filters and obtains extract;
D, the filtrate of combining step B and the extract of step C, revolve and steam except desolventizing, obtain sticky shape paste, be soapberry extract or Rhizoma Polygonati extract.
Described Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent are commercial products or obtain through the following step:
1. Yunnan Melia azedarach L. or Cortex Garciniae dried in the shade, pulverize, enucleation, obtain 120 object powder stocks;
2. in step powder stock 1., add the ethanol of 85%, its liquid ratio L/L counts 5:1, under ultrasonic power 800W, carry out supersound extraction 100min, repeat extraction 4 times, merging filtrate, carries out reduction vaporization by filtrate at 28 DEG C, obtains Yunnan Extractives From Melia Azedarach L or garcinia mangostana extractive;
3. HPD-400 type macroporous adsorbent resin soak with ethanol 24h is carried out remove impurity, activation, step Yunnan Extractives From Melia Azedarach L 2. or garcinia mangostana extractive distilled water are dissolved, and to be made into relative density be 1.1g/cm
3solution, after solution is filtered, get the upper macroporous adsorbent resin of filtrate, controlling applied sample amount is 5g/mL resin, and adsorption rate is 0.5mL/min, use distilled water, 30% ethanol remove impurity more successively, remove impurity speed 1mL/min, collects ethanol elution, elution speed 1.8mL/min, eluent room temperature concentrating under reduced pressure at 25 DEG C is dry, namely obtains Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent.
Described Fructus Gleditsia rice glue is commercial products or obtains through the following step:
A, by saponin rice pulverizing to 600 order, the pure water then adding saponin rice quality 30% stirs, then leaves standstill 3h and make it expand;
B, step a gained mixture is slowly heated to 70 DEG C, and Keep agitation 25min is to the pasty state being dissolved into thickness completely, is then cooled to room temperature, namely obtains Fructus Gleditsia rice glue.
Described thea saponin, neem oil, safflower oil tea fruit oil, Folium Camelliae sinensis spice, Radix Notoginseng total arasaponins, carase, corn extract, Yunnan Folium Menthae extract, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous are commercial products.
Embodiment 4
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 2.3%, soapberry extract 2%,
Thea saponin 2%, neem oil 3%,
Safflower oil tea fruit oil 9%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5%,
Cortex Garciniae antioxidation antifungus agent 0.5%, Folium Camelliae sinensis spice 1%,
Fructus Gleditsia rice glue 0.5%, Rhizoma Polygonati extract 0.5%,
Radix Notoginseng total arasaponins 0.3%, carase 0.1%,
Corn extract 15%, Yunnan Folium Menthae extract 0.3%,
Pure water 22%, calcium phosphate dibasic dihydrate 40%,
Calcium phosphate dibasic anhydrous 8%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, namely obtain natural plant active toothpaste.
Wherein, described Fructus Gleditsiae Abnormalis extract is commercial products or obtains through the following step:
(1) spaonin powder of drying is broken to particle diameter and is less than 5mm;
(2) spaonin powder of 1 part of quality is minced and to soak 24 hours at 40 DEG C with the deionized water of 4 parts of quality, and stir and obtain mixed material;
(3) filtered by step (2) gained mixed material, filtrate boils 5 minutes, then adds the kieselguhr of 0.1%, stirs 30 minutes, refilter and obtain Fructus Gleditsiae Abnormalis extract at 40 DEG C.
Described soapberry extract or Rhizoma Polygonati extract are commercial products or obtain through the following step:
A, the Fructus Sapindi Mukouossi fruit of getting drying or Rhizoma Polygonati, ground, obtained 100 object material powders;
B, mass percent concentration material powder being added 2 parts of quality are extract 2 times in the ethanol water of 60%, then filter, obtain filtrate and filtering residue;
C, filtering residue is carried out soxhlet type, extraction solvent is acetone and ethyl acetate mixed solvent, and temperature is 70 DEG C, and the time is 1 hour, then leaves standstill, and filters and obtains extract;
D, the filtrate of combining step B and the extract of step C, revolve and steam except desolventizing, obtain sticky shape paste, be soapberry extract or Rhizoma Polygonati extract.
Described Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent are commercial products or obtain through the following step:
1. Yunnan Melia azedarach L. or Cortex Garciniae dried in the shade, pulverize, enucleation, obtain 100 object powder stocks;
2. in step powder stock 1., add the ethanol of 70%, its liquid ratio L/L counts 5:1, under ultrasonic power 500W, carry out supersound extraction 500min, repeat extraction 3 times, merging filtrate, carries out reduction vaporization by filtrate at 25 DEG C, obtains Yunnan Extractives From Melia Azedarach L or garcinia mangostana extractive;
3. HPD-400 type macroporous adsorbent resin soak with ethanol 24h is carried out remove impurity, activation, step Yunnan Extractives From Melia Azedarach L 2. or garcinia mangostana extractive distilled water are dissolved, and to be made into relative density be 1.02g/cm
3solution, after solution is filtered, get the upper macroporous adsorbent resin of filtrate, controlling applied sample amount is 5g/mL resin, and adsorption rate is 0.6mL/min, use distilled water, 30% ethanol remove impurity more successively, remove impurity speed 0.9mL/min, collects ethanol elution, elution speed 1.5mL/min, eluent room temperature concentrating under reduced pressure at 35 DEG C is dry, namely obtains Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent.
Described Fructus Gleditsia rice glue is commercial products or obtains through the following step:
A, by saponin rice pulverizing to 400 order, the pure water then adding saponin rice quality 90% stirs, then leaves standstill 1h and make it expand;
B, step a gained mixture is slowly heated to 60 DEG C, and Keep agitation 30min is to the pasty state being dissolved into thickness completely, is then cooled to room temperature, namely obtains Fructus Gleditsia rice glue.
Described thea saponin, neem oil, safflower oil tea fruit oil, Folium Camelliae sinensis spice, Radix Notoginseng total arasaponins, carase, corn extract, Yunnan Folium Menthae extract, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous are commercial products.
For further illustrating effect of the present invention, above-described embodiment gained toothpaste is used for clinical application effect test below.
One, clinical trial object: explore toothpaste provided by the invention to the treatment of all kinds of common oral disease and health-care effect.
Two, patient's grouping: by the 100 routine patients meeting inclusive criteria, random point 2 groups, wherein treatment group 50 example, wherein man 30 example, female 20 example; 9 ~ 70 years old age.Matched group 50 example, wherein man 28 example, female 22 example; 9 ~ 70 years old age.Patient is primary care, and two groups of ages, sex, the course of disease and cardinal symptoms are through statistical procedures, and no significant difference (P>0.05), has comparability.
Inclusive criteria: the gingival hemorrhage that (1) causes because of periodontitis, gingivitis etc.; (2) dentin hypersensitiveness phenomenon is obvious, especially to the food such as hot and cold, sweet, sour and liquid food all irritated; (3) halitosis; (4) tooth is significantly yellow.
Three, Therapeutic Method
Treatment group: by above-described embodiment gained toothpaste, every day respectively brushes teeth once sooner or later, and service time is 1 month.
Matched group: the use mica filled polypropylene of gingival hemorrhage and halitosis, dentin hypersensitiveness use the use Colgate-Palmolive toothpaste of lengsuanling toothpaste, tooth Huang, and every day respectively brushes teeth once sooner or later, and service time is 1 month.
Four, result
Therapeutic outcome:
The effective percentage for the treatment of group to gingival hemorrhage reaches 99%; 96% is reached to the effective percentage of dentin hypersensitiveness; 100% is reached to the effective percentage of halitosis; 97% is reached to the effective percentage of tooth Huang.
The effective percentage of matched group to gingival hemorrhage reaches 70%; 50% is reached to the effective percentage of dentin hypersensitiveness; 80% is reached to the effective percentage of halitosis; 40% is reached to the effective percentage of tooth Huang.
Treatment group compares with matched group effective percentage, and treatment group aggregate efficiency is 98%, and matched group is 60%, and analyze through Ridit, P<0.05, treatment group is better than matched group.
Five, conclusion
Dentifrice treatment effect provided by the invention is better than matched group, and simply, safely, have no side effect, no pain, to common oral disease, there is remarkable result.
In sum, toothpaste provided by the invention has effects such as significantly repairing impaired mucosa, antiinflammatory, pain relieving, hemostasis, pure white, fresh breath, has remarkable result to the common oral disease such as dental hemorrhage, dentin hypersensitiveness, halitosis that periodontitis, gingivitis cause.Without any side effects, be applicable to life-time service, and safely, effectively, clinic is promoted.
Claims (6)
1. a natural plant active toothpaste, is characterized in that being made up of the component of following masses percentage composition:
Fructus Gleditsiae Abnormalis extract 2 ~ 3%, soapberry extract 2 ~ 3%,
Thea saponin 2 ~ 3%, neem oil 3 ~ 5%,
Safflower oil tea fruit oil 9 ~ 15%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5 ~ 1%,
Cortex Garciniae antioxidation antifungus agent 0.5 ~ 1%, Folium Camelliae sinensis spice 1 ~ 1.5%,
Fructus Gleditsia rice glue 0.5 ~ 1%, Rhizoma Polygonati extract 0.5 ~ 1%,
Radix Notoginseng total arasaponins 0.3 ~ 0.5%, carase 0.1%,
Corn extract 15 ~ 20%, Yunnan Folium Menthae extract 0.3 ~ 0.5%,
Pure water 22 ~ 25%, calcium phosphate dibasic dihydrate 15 ~ 40%,
Calcium phosphate dibasic anhydrous 1 ~ 5%,
The summation of said components is 100%.
2. natural plant active toothpaste according to claim 1, is characterized in that: described Fructus Gleditsiae Abnormalis extract is commercial products or obtains through the following step:
(1) spaonin powder of drying is broken to particle diameter and is less than 5mm;
(2) in the spaonin powder of step (1), add deionized water by the mass ratio of 1:4 ~ 6, soak 18 ~ 24 hours at 40 ~ 60 DEG C, and stirring obtains mixed material;
(3) filtered by step (2) gained mixed material, filtrate boils 5 ~ 10 minutes, then adds the kieselguhr of 0.1 ~ 3%, stirs 30 ~ 50 minutes, refilter and obtain Fructus Gleditsiae Abnormalis extract at 40 ~ 50 DEG C.
3. natural plant active toothpaste according to claim 1, is characterized in that: described soapberry extract and Rhizoma Polygonati extract are commercial products or obtain through the following step:
A, the peel of Fructus Sapindi Mukouossi getting drying or Rhizoma Polygonati, grind to 100 ~ 200 orders, obtain raw material powder;
B, in the raw material powder of steps A, by the mass ratio of 1:2 ~ 3 add mass concentration be 60 ~ 80% ethanol water extract 2 ~ 3 times, filter to get filtrate and filtering residue;
C, filtering residue is carried out soxhlet type, extraction solvent is acetone and ethyl acetate mixed solvent, temperature is 60 ~ 80 DEG C, the time is 1 ~ 2 hour, then leave standstill, filter and obtain extract;
D, the filtrate of combining step B and the extract of step C, revolve and steam except desolventizing, obtain sticky paste, be soapberry extract or Rhizoma Polygonati extract.
4. natural plant active toothpaste according to claim 1, is characterized in that: described Yunnan Melia azedarach L. bacteriostatic preservative and Cortex Garciniae antioxidation antifungus agent are commercial products or obtain through the following step:
1. Yunnan Melia azedarach L. or Cortex Garciniae dried in the shade, pulverize, enucleation, obtain 80 ~ 120 object powder stocks;
2. in step powder stock 1., the ethanol that mass concentration is 70 ~ 95% is added, its liquid ratio counts the volume ratio L/L of 5:1, supersound extraction 50 ~ 100min is carried out under ultrasonic power 500 ~ 800W, repeat extraction 3 ~ 4 times, merging filtrate, filtrate is carried out reduction vaporization at 25 ~ 30 DEG C, obtains Yunnan Extractives From Melia Azedarach L or garcinia mangostana extractive;
3. HPD-400 type macroporous adsorbent resin soak with ethanol 24h is carried out remove impurity, activation, step Yunnan Extractives From Melia Azedarach L 2. or garcinia mangostana extractive distilled water are dissolved, and to be made into relative density be 1.02 ~ 1.20g/cm
3solution, after filtering, get the upper macroporous adsorbent resin of filtrate, controlling applied sample amount is 4 ~ 5g/mL resin, and adsorption rate is 0.5 ~ 0.6mL/min, use distilled water, 30% ethanol remove impurity more successively, remove impurity speed 0.8 ~ 1mL/min, collects ethanol elution, elution speed 1.5 ~ 2.0mL/min, eluent room temperature concentrating under reduced pressure at 25 ~ 35 DEG C is dry, namely obtains Yunnan Melia azedarach L. bacteriostatic preservative or Cortex Garciniae antioxidation antifungus agent.
5. natural plant active toothpaste according to claim 1, is characterized in that: described Fructus Gleditsia rice glue is commercial products or obtains through the following step:
A, by saponin rice pulverizing to 400 ~ 600 order, the pure water then adding 30 ~ 90% of saponin rice quality stirs, then leaves standstill 1 ~ 3h and make it expand;
B, step a gained mixture is slowly heated to 60 ~ 80 DEG C, and Keep agitation 20 ~ 30min is to the pasty state being dissolved into thickness completely, is then cooled to room temperature, namely obtains Fructus Gleditsia rice glue.
6. a preparation method for natural plant active toothpaste, is characterized in that through each step of getting off:
1) get the raw materials ready by the component of following mass percentage:
Fructus Gleditsiae Abnormalis extract 2 ~ 3%, soapberry extract 2 ~ 3%,
Thea saponin 2 ~ 3%, neem oil 3 ~ 5%,
Safflower oil tea fruit oil 9 ~ 15%, Yunnan Melia azedarach L. bacteriostatic preservative 0.5 ~ 1%,
Cortex Garciniae antioxidation antifungus agent 0.5 ~ 1%, Folium Camelliae sinensis spice 1 ~ 1.5%,
Fructus Gleditsia rice glue 0.5 ~ 1%, Rhizoma Polygonati extract 0.5 ~ 1%,
Radix Notoginseng total arasaponins 0.3 ~ 0.5%, carase 0.1%,
Corn extract 15 ~ 20%, Yunnan Folium Menthae extract 0.3 ~ 0.5%,
Pure water 22 ~ 25%, calcium phosphate dibasic dihydrate 15 ~ 40%,
Calcium phosphate dibasic anhydrous 1 ~ 5%, the summation of said components is 100%;
2) each component and pure water are mixed to dissolve completely, and vacuum outgas, then continuing stirs makes into paste, then after colloid mill grinding, carries out vacuum outgas, obtain natural plant active toothpaste.
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| CN105534786A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Special care toothpaste for middle aged and elderly people |
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| CN109793861A (en) * | 2017-11-17 | 2019-05-24 | 贵州省台江县乡土农业科技开发有限公司 | A kind of Chinese medicine preparation for treating implication |
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| CN105147583A (en) * | 2015-09-30 | 2015-12-16 | 福建春辉生物工程有限公司 | Special camellia-saponin-contained toothpaste for child and preparation method thereof |
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| CN108371648A (en) * | 2018-03-21 | 2018-08-07 | 桂林良物造日用品有限公司 | One kind containing diatomaceous natural activity toothpaste and preparation method thereof |
| CN108524404A (en) * | 2018-07-11 | 2018-09-14 | 安徽人民健康生物科技有限公司 | A kind of sealwort herbaceous toothpaste |
| CN111870687A (en) * | 2020-08-12 | 2020-11-03 | 好易康生物科技(广州)有限公司 | Oral bacteriostatic composition, oral care solution prepared from oral bacteriostatic composition and application of oral care solution |
| CN111956593A (en) * | 2020-09-22 | 2020-11-20 | 福建省梦娇兰日用化学品有限公司 | Children toothpaste containing probiotics and preparation method thereof |
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