CN108042420A - A kind of composition and its application for oral health - Google Patents
A kind of composition and its application for oral health Download PDFInfo
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- CN108042420A CN108042420A CN201711386699.XA CN201711386699A CN108042420A CN 108042420 A CN108042420 A CN 108042420A CN 201711386699 A CN201711386699 A CN 201711386699A CN 108042420 A CN108042420 A CN 108042420A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention relates to daily chemical products technical fields, and in particular to a kind of composition and its application for oral health.The composition by weight, including：0.001~15 part of camomile tincture, 0.001~12 part of La Tanni extracts, 0.002~10 part of myrrh tincture.Composition provided by the present invention can also further comprise the one or more in soapberry extract, totarol, 5 alcohol of o cymenes, thymol, Paeonol.Composition provided by the invention has possessed excellent antibacterial action, and available for oral health-care product or drug is prepared, can not only clean oral cavity, can also kill helicobacter pylori, while has good therapeutic effect to halitosis, and can significantly inhibit plaque.
Description
Technical field
The present invention relates to daily chemical products technical fields, and in particular to a kind of composition and its application for oral health.
Background technology
Halitosis, also known as implication refer to the foul foul smell of exhalation in mouth.Since halitosis often makes others be sick of, makes oneself awkward
A word used for translation, therefore dare not closely be associated with people with the people (especially young man) of halitosis, seriously affect people social interaction and
Mental health, at present, WHO are reported using halitosis as a kind of disease.It is shown according to investigation, Chinese halitosis illness rate is
27.5%, it is then 50% in western countries, the people that the whole world has 10%~65% once suffers from halitosis.
The type of halitosis can be divided into physiological halitosis and pathologic halitosis.Physiological halitosis be due to usually in life not
Pay attention to oral hygiene, swill accumulates for a long time in mouth, and corruption of fermenting under the action of bacterium is decomposed, generate indoles sulfydryl and
The substances such as amine send a kind of rotten stench.Physiological halitosis can remove by strengthening oral hygiene, need not especially control
It treats.Pathologic halitosis on the one hand can be caused by oral problems such as plaque, tooth saprodontias, on the other hand can by acute or chronic gastritis, disappear
The internal diseases such as acid smell, which occurs, in Peptic-ulcer to be caused.And trigger acute or chronic gastritis Important cause of disease be infection helicobacter pylori.
Helicobacter pylori can enter from mouth, be deposited with cavity interior, enter stomach by swallowing act, and infection is settled down after reaching gastric mucosa,
Trigger chronic, superficial gastritis through several weeks or several months, develop into duodenal ulcer, gastric ulcer, leaching after several years or many decades
Bar Hypertrophic gastric lymphoma, atrophic gastritis etc., and the latter is the factor for causing stomach cancer most dangerous.And there is disease of stomach
Afterwards, problem of bad breath can be triggered.Therefore, the treatment needs of pathologic halitosis are started with from mouth disease and internal disease, fundamentally
It is treated.
The present invention exploitation it is a kind of can comprehensive removing halitosis dental products, can remove oral cavity bacterium, inhibit tooth
Bacterial plaque, and intraoral helicobacter pylori can be killed, while can also aid in shortening the stomach problems triggered by helicobacter pylori
Dental products, had a very important significance for halitosis patient.
The content of the invention
The present invention provides a kind of composition for oral health, can not only clean oral cavity, can also kill pylorus spiral shell
Bacillus, while remove oral cavity bacterium, inhibit plaque, auxiliary shortens the stomach problems triggered by helicobacter pylori, from external source
And endogenous solution problem of bad breath.
Composition of the present invention includes：
0.001~15 parts by weight of camomile tincture,
0.001~12 parts by weight of Brittany extract are drawn,
0.002~10 parts by weight of myrrh tincture.
Preferably, the composition includes：
0.5~4 parts by weight of camomile tincture,
0.5~4 parts by weight of Brittany extract are drawn,
0.1~1 parts by weight of myrrh tincture.
Among component employed in the present invention, camomile tincture is feverfew chamomile Matricaria chamomilla
L. drying herb extract mainly contains flavones, saponin(e, polysaccharide, volatile oil isoreactivity ingredient, to golden staphylococci, hammer
Bacterium and candida albicans etc. have the activity inhibited.
The root of Brittany is drawn just to be used to treat oral inflammation and damage since ancient times by Peruvian.Draw the root extract tool of Brittany
There are abundant benzofuran content, Ellagitannins and protocatechuic tannin content, multiple-microorganism, especially gram can be inhibited
Positive bacteria and the breeding of fungi.The alcohol extract or water extract of the present invention that Brittany extract is drawn as ratanhia, it is excellent
Select alcohol extract.
Myrrh tincture contains Eugenol and multiple efficacies ingredient, has certain antibacterial action.
The present invention creatively has found mentioned component being combined in specific proportions, and the effect of the composition of gained is better than
The combination of single or two kinds of ingredients shows that there is a synergy between for these three ingredients.
Preferably, above-mentioned composition of the present invention is further included selected from soapberry extract, totarol, o- cymene -5- alcohol, hundred
In one or more in phenol, Paeonol.
Wherein, when selecting any one of said components, dosage is in the composition：
Preferably, dosage is each component in the composition：
Soapberry is always China's common natural washing articles for use among the people from ancient times, and there is antibacterial, anti-dandruff, anticreep, whitening to go
Spot, skin care and other effects, the soapberry extract are soapberry ethyl alcohol and/or the extract of water.
Totarol is the heartwood for extracting from peach three-bristle cudrania podocarpus, is a kind of natural bactericide, has outstanding resist
The activity of Gram-negative bacteria, positive bacteria has the bacterium for causing decayed tooth and halitosis very high inhibitory activity.
O- cymene -5- alcohol is the wide leaf cuckoo of ericad (Ledum palustre L.var dilatatum
Wahlanberg active ingredient), the phlegm-dispelling functions and anti-inflammatory effect having can be used as preservative.
The phenolic aldehyde monoterpene that thymol can be extracted from various plants (such as thyme) essential oil has very strong antibacterial
Effect.The thymol is preferably WellcapTM Thymol, and WellcapTM Thymol are using WellcapTM fabrication techniques
Thymol nano-microcapsule, the stability and antibacterial ability of thymol can be improved.
Paeonol is moutan bark medicinal material main composition, has clearing heat and cooling blood, activates blood circulation and disperses blood clots, reducing the asthenic fever and other effects, together
When have bacteriostatic activity.
It it is an unexpected discovery of the invention that will be in soapberry extract, totarol, o- cymene -5- alcohol, thymol and Paeonol
One or more make an addition in composition, the effect of composition can be further improved.
As the preferred embodiment of the present invention, a kind of composition is provided, formula is as follows：
Using the composition of above-mentioned formula, the synergistic effect of its each ingredient can be played to greatest extent.
Most preferably, it is as follows：
The present invention also provides compositions described in any one of the above embodiments to prepare the drug object or oral health-care product for the treatment of halitosis
In application.
Application of any one composition in oral health-care product is prepared specially described in above-mentioned technical proposal.
The present invention also provides a kind of oral health-care product, including any one composition described in above-mentioned technical proposal.
The present invention also provides a kind of mouthwash, including：
The moisturizer is selected from one or more of sorb (sugar) alcohol, propylene glycol, glycerine, polyethylene glycol-8；
The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl first
One or more of base sodium taurocholate；
The thickener is selected from one or more of cellulose, card ripple, carragheen；
The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex
One or more of peppermint；
The color of the colorant is selected from one or more of green, blueness, red.
Preferably, above-mentioned mouthwash further includes following any one or more components, when selecting any component, in institute
The dosage stated in composition is as follows：
Said components are added, mouthwash provided by the present invention can effectively kill helicobacter pylori in mouth, inhibit tooth
Bacterial plaque, ancillary drug shorten the time cured needed for gastric ulcer, so as to show the excellent effect for going halitosis.
Preferably, dosage is each component in the composition：
Said components are dissolved in solvent, and the solvent is deionized water；It is preferred that it is mended with the solvent to 100 weight
Part.
As the preferred embodiment of the present invention, a kind of mouthwash is provided, total weight parts are 100 parts, and formula is as follows：
The mouthwash of above-mentioned offer coordinates the regulation and control of parts by weight by the special selection to ingredient, can be maximumlly sharp
With the synergistic effect of its each component, the preferably effect for the treatment of or auxiliary treatment mouth disease is played.
The present invention provides the preparation method of above-mentioned mouthwash together, and above-mentioned each component is mixed to obtain the final product.Conventional side can be used
Method is made, and the present invention does not do specifically limited, only provides a kind of more preferred preparation method：
Specific steps include：
1) thickener is distributed in moisturizer, adds in deionized water, be heated to 90 sterilizings, be dispersed with stirring uniformly.
2) after the dissolving of addition surfactant is uniformly dispersed, cool down.
3) 38 DEG C are cooled to, adds in ethyl alcohol, camomile tincture, La Tanni extracts, myrrh tincture, food flavor, colorant, stirring
It uniformly can filtering and discharging.
The present invention provides a kind of toothpaste, including：
The rubbing agent is selected from silica, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, burnt phosphorus
One or more of sour calcium；
The moisturizer is selected from sorb (sugar) alcohol, glycerine, propylene glycol, one or more of polyethylene glycol-8, butanediol；
The foaming agent is selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid
One or more of sodium, cocounut oil acyl methyl taurine sodium；
The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar gum hydroxypropyl three
One or more of ammonio methacrylate, carrageenan, locust bean gum；
The sweetener is selected from saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside, sweet Momordica grosvenori
One or more of glycosides；
The essence is selected from one or more of vanilla, spearmint, minty note, Chinese ilex peppermint；
The preservative is selected from one or more of benzoic acid and its esters, sorbic acid and its esters, parabens；
The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake, clean the teeth one or more of particle；
The above components dissolve in a solvent, and the solvent is deionized water；It is preferred that it is mended with the solvent to 100 parts.
Preferably, the toothpaste, including solvent and following component：
And the one or more in soapberry extract, totarol, o- cymene -5- alcohol, thymol, Paeonol,
When selecting any component, dosage in the composition is as follows：
Preferably,
Toothpaste provided by the present invention has effects that existing removing oral cavity bacterium, inhibits plaque, and has killing mouth
The helicobacter pylori of intracavitary has the advantages that comprehensive removing halitosis.
The present invention also provides a kind of preparation method of above-mentioned toothpaste, including：Above-mentioned each component is mixed, tooth is made
Cream.It is as follows：
1) camomile tincture, La Tanni extracts, myrrh tincture are dissolved in moisturizer, high-speed stirred, are prepared into the first mixing
Liquid；
2) thickener is added in the first mixed liquor, stirring obtains the second mixed liquor；
3) appearance modifying agents are added in into the second mixed liquor, stirs, obtains the 3rd mixed liquor；
4) the 3rd mixed liquor, sweetener, rubbing agent, essence, foaming agent, preservative are added in into solvent, stirring obtains the
Four mixed liquors；
5) the 4th mixed liquor continues to stir under vacuum condition 0.08-0.12MPa, and lotion is made.
6) examine, sterile filling enters in aluminum plastic composite pipe, seals, and toothpaste is made.
Composition provided by the present invention includes camomile tincture, La Tanni extracts, myrrh tincture, and the present invention is specific by selecting
Ingredient, using the different medical mechanisms of heterogeneity, be combined with reference to specific ratio, make full use of the association between each ingredient
Same-action so that the composition of gained, which has, efficiently removes the halitosis that various approach trigger, including killing helicobacter pylori, clearly
Except plaque, auxiliary treatment gastric ulcer etc. dispel the effect of halitosis.
Specific embodiment
Following embodiment is not limited to the scope of the present invention for illustrating the present invention.
Embodiment 1
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
2 parts of camomile tincture,
2 parts of Brittany extract is drawn,
0.85 part of myrrh tincture.
Embodiment 2
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 3
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 4
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 5
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 6
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 7
The present embodiment provides a kind of composition for oral health, concrete component is as follows：
Embodiment 8
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 9
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 10
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 11
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 12
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 13
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 14
The present embodiment provides a kind of mouthwashes, total weight parts 100, and concrete component is as follows：
Embodiment 15
The present embodiment provides a kind of toothpaste, total weight parts 100, and concrete component is as follows：
Embodiment 16
The present embodiment provides a kind of toothpaste, total weight parts 100, and concrete component is as follows：
Embodiment 17
The present embodiment provides a kind of toothpaste, total weight parts 100, and concrete component is as follows：
Embodiment 18
The present embodiment provides a kind of toothpaste, total weight parts 100, and concrete component is as follows：
Embodiment 19
The present embodiment provides a kind of toothpaste, total weight parts 100, and concrete component is as follows：
Comparative example 1-5
Comparative example 1-5 provides the composition for oral health, and concrete component is as follows：
Comparative example 6-10
Comparative example 6-10 provides the formula of mouthwash, specific as follows：
Comparative example 11
This comparative example provides a kind of formula of mouthwash, and total weight 100g is formulated as follows：
Said components are uniformly mixed, mouthwash is made in the filtering of 0.22 micron membrane filter.
Test example 1
This test example provides embodiment 1-5, the bacteriostatic experiment and its data of the composition that comparative example 1-5 is provided.
1. the preparation of culture medium：
The preparation of helicobacter pylori fluid nutrient medium：Weigh proteose peptone 10.0g；Bovine brain leaches powder 10.0g；Cattle heart
Leach powder 9.0g；Sodium chloride 5.0g；Glucose 2.0g；Disodium hydrogen phosphate 2.5g with distillation water dissolution and is settled to 1000g, and 121
DEG C high pressure sterilization 15 minutes when being cooled to 50~55 DEG C, adds in 7ml aseptic de-fiber sheep bloods and 1 HP bacteriostatic agent (contains containing naphthyridones
Sour 1mg, TMP 0.5mg, vancomycin 0.3mg, amphotericin B 0.2mg), mixing dispenses, spare.
The preparation of helicobacter pylori solid medium：The agar of addition 1.5% on the basis of aforesaid liquid culture medium
Solid medium is made with same method in powder.
2. bacteriostatic test：
Bacterial strain activates：The helicobacter pylori of 0.1ml freeze thawing is taken to preserve bacterial strain and is coated on helicobacter pylori solid culture
On base, (the N in 36 DEG C of micro- aerobic environments285%, CO210%, O25%) 72h is cultivated.
The preparation of bacterium suspension：Helicobacter pylori of the ring through overactivation is taken in 10ml helicobacter pylori Liquid Cultures
Base, (N in micro- aerobic environment285%, CO210%, O25%) culture is to bacteria concentration up to 1 × 108CFU ml-1。
The preparation of body fluid culture medium containing composition：The combination of 4.85g comparative examples 1~5 and Examples 1 to 5 is weighed respectively
Object is dissolved with pylori fluid nutrient medium and supplies 100g.
Bacteriostatic test：1ml bacterium suspensions is taken to add in body fluid culture mediums of the 100g containing different components, and to be free of combination
Object pylori fluid nutrient medium is blank control, (N in micro- aerobic environment285%, CO210%, O25%) after cultivating 3d,
With spectrophotometric determination bacterium solution OD values, and according to formula bacteriostasis rate=(blank control OD values-composition OD values)/blank control
OD values × 100% calculates the bacteriostasis rate of each composition.
Fungistatic effect is as shown in table 1：
The fungistatic effect experimental data of 1 different components of table
From the above results, the composition of embodiment has strong inhibition to the breeding and growth of helicobacter pylori
Activity.
Test example 2
This test example provides the human trial of embodiment 8-14, the mouthwash that comparative example 6-11 is provided (to plaque
Therapeutic effect) and its data.
Volunteer person of the selection with plaque carries out normal individual trial experiment.It is tight that plaque first is carried out to volunteer before on probation
Weight assessment of scenario, and be grouped according to plaque serious conditions, every group of 25 people, every group is tried out different mouthwashes respectively, often
It once in the morning and once at night assesses the serious conditions of plaque again after 6 months.
The serious conditions standards of grading of plaque are as follows：
0 point：Without bacterial plaque.
1 point：Bacterial plaque is located at neck portion, in being dispersed in spot distribution.
2 points：Bacterial plaque is located at neck portion, linear, and width is 1 millimeter.
3 points：1 millimeter of the width G T.GT.GT of bacterial plaque, but end reaches the l/3 of corona.
4 points：The width of bacterial plaque reaches the l/3 of corona, but end reaches the 2/3 of corona.
5 points：The width of bacterial plaque reaches 2/3 of corona or more.
The results are shown in Table 2：
Table 2 is scored using the plaque before and after different mouthwashes
Test example 3
This test example provides the human trial of embodiment 8-14, the mouthwash that comparative example 6-11 is provided (to gastric ulcer
Adjuvant treatment effect) and its data.
Selection has gastric ulcer case history 2 years or more, recurrent exerbation, in stage of attack, and when duration of seizure 48 is small in patient
Participate in adjuvant treatment effect of the mouthwash to gastric ulcer.It is grouped at random according to test specimen number, every group of 25 people, each group difference
It using the mouthwash in embodiment and comparative example, respectively uses once sooner or later daily, while takes the stomach bismuth magnesium of same dose, count
Gastric ulcer healing time, and count from gastric ulcer recurrence rate in 12 each moons after healing.
The results are shown in Table 3：
To the adjuvant treatment effect of gastric ulcer after the different mouthwashes of the use of table 3
Test example 4
The human trial that this test example provides embodiment 8-14, the mouthwash that comparative example 6-11 is provided (is controlled halitosis
Therapeutic effect) and its data.
Volunteer (volunteers of various halitosis types) of the selection with serious pathological halitosis participates in mouthwash to halitosis
Therapeutic effect experiment.It first scores volunteer, and is grouped at random, every group of 25 people before on probation, every group is tried out difference respectively
Mouthwash, once in the morning and once at night, halitosis scoring is carried out after 30 days again.Halitosis scoring uses the side of scoring of Rosenberg
Case, it is specific as follows：
0 point, no halitosis, affirmative does not smell a strange smell.
1 point, suspicious halitosis, like audible and peculiar smell.
2 points, slight halitosis, news and peculiar smell, but very slight certainly.
3 points, moderate halitosis, hence it is evident that halitosis.
4 points, severe halitosis, but examiner still bears hard.
5 points, fetor, examiner can not endure.
The results are shown in Table 4：
To the therapeutic effect of pathologic halitosis after the different mouthwashes of the use of table 4
From the above results, the mouthwash containing example composition can effectively kill helicobacter pylori in mouth,
Inhibition bacterial plaque, ancillary drug shorten the time cured needed for gastric ulcer, so as to show excellent effect.
Although above having used general explanation, specific embodiment and experiment, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. a kind of composition, which is characterized in that by weight, including：
0.001~15 part of camomile tincture,
0.001~12 part of Brittany extract is drawn,
0.002~10 part of myrrh tincture；
Preferably, including：
0.5~4 part of camomile tincture,
0.5~4 part of Brittany extract is drawn,
0.1~1 part of myrrh tincture.
2. composition according to claim 1, which is characterized in that the composition is further included selected from soapberry extract
0.01~25 parts by weight, 0.0003~1 parts by weight of totarol, 0.001~0.5 parts by weight of o- cymene -5- alcohol, thymol
One or more in 0.0005~1 parts by weight, 0.001~1 parts by weight of Paeonol；
Preferably, the composition further include selected from 0.1~0.85 parts by weight of soapberry extract, the totarol 0.01~
0.48 parts by weight, 0.05~0.5 parts by weight of o- cymenes -5- alcohol, 0.05~0.1 parts by weight of the thymol, the pellet
One or more in 0.1~0.15 parts by weight of skin phenol.
3. composition according to claim 1 or 2, which is characterized in that the composition in parts by weight, including：
4. application of the claim 1-3 any one of them composition in the drug or oral health-care product for preparing treatment halitosis.
5. a kind of oral health-care product, which is characterized in that including claim 1-3 any one of them compositions.
6. oral health-care product according to claim 5, the oral health-care product is mouthwash, is dissolved in the composition
Mixing in deionized water to obtain the final product；
Preferably, the mouthwash by weight, is further included selected from 0~10 parts by weight of moisturizer, 0~5 weight of surfactant
Measure part, 0~5 parts by weight of thickener, 0~25 parts by weight of ethyl alcohol, 0~5 parts by weight of food flavor, in 0~1 parts by weight of colorant
It is one or more of.
7. oral health-care product according to claim 6, the mouthwash by weight, including：
It is preferred that total weight parts are 100 parts.
8. the oral health-care product according to claim 6 or 7, which is characterized in that in the mouthwash, the moisturizer is selected from
One or more of D-sorbite, propylene glycol, glycerine, polyethylene glycol-8；
The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl methyl ox
One or more of sodium sulfonate；
The thickener is selected from one or more of cellulose, card ripple, carragheen；
The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex peppermint
One or more of；
The color of the colorant is selected from one or more of green, blueness, red.
9. oral health-care product according to claim 5, the oral health-care product is toothpaste, and the toothpaste is by weight also
Including：
Preferably, mended with deionized water to 100 parts by weight.
10. oral health-care product according to claim 9, which is characterized in that in the toothpaste, the rubbing agent is selected from dioxy
One or more of SiClx, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, calcium pyrophosphate；
The moisturizer is selected from one or more of D-sorbite, glycerine, propylene glycol, polyethylene glycol-8, butanediol；
The foaming agent be selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid sodium,
One or more of cocounut oil acyl methyl taurine sodium；
The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar hydroxypropyltrimonium
One or more of ammonium chloride, carrageenan, locust bean gum；
The sweetener is in saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside, mogroside
One or more；
The essence is selected from one or more of vanilla, spearmint, minty note, Chinese ilex peppermint；
The preservative is selected from one or more of benzoic acid and its esters, sorbic acid and its esters, parabens；
The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake, clean the teeth one or more of particle.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010404A (en) * | 2018-09-26 | 2018-12-18 | 广东南方洁灵科技实业有限公司 | A kind of anti-helicobacter pylori oral cavity compound and its preparation method and application |
| CN110478298A (en) * | 2019-09-23 | 2019-11-22 | 沈阳天然纳美科技有限公司 | A kind of composition and its preparation method and application with oral health function |
| CN110613631A (en) * | 2019-10-28 | 2019-12-27 | 青岛明月海藻生物健康科技集团有限公司 | Fucoidin delicate antibacterial composition for oral care products |
| CN114948805A (en) * | 2021-02-23 | 2022-08-30 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood herb volatile oil and application of antibacterial composition in acne-removing skin care product |
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