CN108606939A - A kind of composition and its application and preparation method with oral health function - Google Patents
A kind of composition and its application and preparation method with oral health function Download PDFInfo
- Publication number
- CN108606939A CN108606939A CN201810210198.4A CN201810210198A CN108606939A CN 108606939 A CN108606939 A CN 108606939A CN 201810210198 A CN201810210198 A CN 201810210198A CN 108606939 A CN108606939 A CN 108606939A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- composition
- sodium
- toothpaste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of composition with oral health function and its application and preparation methods.The composition by weight, including 0.01 2 parts by weight of narrow leaved tea tree essential oil, 0.02 5 parts by weight of Arnica.The composition can also include selected from one or more of medicine Salvia japonica, Moschus leaf extract, mulberry leaf, chrysanthemum, pueraria lobata, radix bupleuri, radix scutellariae, the coptis, Herba Andrographitis, honeysuckle, dandelion, the wooden sodium azulenesulfonate.The present invention utilizes the different medical mechanism of each ingredient; give full play to the synergistic function between each ingredient; the composition of gained is allow to prevent the formation with co-treatment sensitivity of tooth, inhibition plaque; while can inhibit a variety of oral cavity bacteriums such as helicobacter pylori, also there is prophylaxis of teeth sensitivity, protection gum and other effects.
Description
Technical field
The present invention relates to daily chemical products technical fields, and in particular to a kind of composition with oral health function and its answers
With and preparation method.
Background technology
Intraoral pathogenic bacteria have the health in oral cavity certain harm.Research confirms at present, known bacterium in oral cavity
Type up to more than 700 is planted, and in oral cavity between microorganism, between microorganism and host buccal tissue, only keeps good ecology
Balance, oral cavity can just keep fit state.If external microorganism or since other factors influence, cause in Oral health behaviours solid
The individual or several microorganism ratios having obviously increase the advantage (ratio of especially pathogenic bacteria increases) as field planting position, former
Some Oral health behaviours balances are broken, it will flora imbalance are occurred, led to mouth disease.Common mouth disease has：Saprodontia,
Periodontitis, gingivitis and halitosis etc.
When saprodontia occurs for enamel, streptococcus mutans or edge the streptococcus ratio in the flora of enamel surfaces obviously increase
Add, generation, the development of Bacillus acidi lactici and dental caries are closely related.Numerous studies show that streptococcus mutans are cause saprodontia main
Reason also has document confirmation, streptococcus mutans to may also lead to the generation of gingivitis.Porphyromonas gingivalis, actinobacillus actinomycetem comitans are
Anaerobic bacteria plays an important role in the morbidity of periodontitis.Candida albicans, streptococcus, staphylococcus can cause bacillary bicker
Inflammation, Candida albicans can also cause the infection of oral mucosa under certain condition, staphylococcus aureus then with skin infection, flat
Peach adenositis and respiratory tract infection are closely bound up.Fusobacterium nucleatum, treponema denticola are the main reason for leading to halitosis.
In addition, in daily life, tooth often occurs the phenomenon that hot acid sweet tea influences and generates tingle, pain to the cold, this is just
The sensitivity of tooth being known as.To find out its cause, being all mostly since tooth abrasion, gingival atrophy, Root exposnre etc. make tooth sheet
Caused by matter exposure, then stimulates lower dentine cytoplasmic process to play conduction and cause condition susceptible；Can also by the change of dental pulp blood circulation,
Such as tooth jaw wound, the hyperemia of root of the tooth tip influences and condition susceptible occurs.With advancing age, the frequency of sensitivity of tooth is more prominent
Go out, has seriously affected people’s lives quality.Commercially available much toothpaste are by closing dentinal tubule, inhibiting liquid in canaliculi dentales
Flowing, cut off dentine and Intradental nerve conduction, to which dentine be mitigated or eliminated caused by ache.Strontium chloride, potassium nitrate
It can play the role of closing canaliculi dentales, to mitigate sensitivity of tooth.But strontium chloride, potassium nitrate have certain poison is secondary to make
With.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of dental products, can not only clean oral cavity, the present invention can inhibit
Also there is prophylaxis of teeth sensitivity, protection gum and other effects while a variety of oral cavity bacteriums such as helicobacter pylori.
The present invention adopts the following technical scheme that realization.A kind of composition for oral cavity, including following parts by weight
Component：
Narrow leaved tea tree essential oil 0.01-2 parts by weight；
Arnica extract 0.02-5 parts by weight；
Preferably,
Narrow leaved tea tree essential oil 0.05-1 parts by weight；
Arnica extract 0.08-3 parts by weight；
In the present invention, the narrow leaved tea tree essential oil is the alcohol extract of narrow leaved tea tree.Narrow leaved tea tree (MELALEUCA
ALTERNIFOLIA) also known as it is coastal to originate in Australian South New South Wales for tea oil tree, category Myrtaceae paperbark
One band, it is civil to be commonly used to anti-infective, anti-inflammatory and treatment diarrhea and wound.It extracts and obtains from the fresh branches and leaves of narrow leaved tea tree
Narrow leaved tea tree essential oil, trade name tea oil (Tea tree oil) has broad-spectrum antiseptic, antimycotic, antiviral, anti-inflammatory
Activity, to Escherichia coli of going out, staphylococcus aureus, staphylococcus epidermis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans etc.
With stronger anti-microbial property.It is widely used in the system of fragrance, preservative in preparation for external application to skin, disinfectant and cosmetics in recent years
It is standby.
Heretofore described Arnica extract is the tincture of Arnica.Arnica (Arniea montana) be Europe and
The conventional medicament of North America, head titbit have the function of anti-inflammatory and wound healing.Arnica extract main active component
For sesquialter terpene lactone class compound and flavone compound, courbature, rheumatalgia are sprained for treating extravasated blood, stimulates siberian crabapple
System.Arnica extract promotes the healing after local damage, reduces scratch and mitigate myalgia for treating skeletal muscle disease
Bitterly；External application can treat operation after, caused skin scar after laser therapy or after wound.There is arnica tincture on European ＆ American Market at present
Agent, ointment, gelling agent sale, tincture therein are also included into European Pharmacopoeia.
Preferably, the composition further includes medicine Sage extract, Moschus leaf extract, mulberry-leaf extract, chrysanthemum
Extract, kudzu root extract, bupleurum extract, Baical Skullcap root P.E, coptis extract, Andrographis Paniculata, Honegsukle flower P.E,
One or more of dandelion extract, wooden sodium azulenesulfonate more preferably include above-mentioned whole components.
Wherein, dosage is respectively each component in the composition：
Preferably, the composition includes：
It can further significantly it is an unexpected discovery of the invention that adding one or more of above-mentioned raw materials in above-mentioned composition
The effect of improving composition.
Above-mentioned Sage extract is the alcohol extract of Salvia japonica；Salvia japonica (Salvia officinalis) is lip
Section, salvia, one, biennial or herbaceos perennial and evergreen dwarf shrub, leaf, stem and Hua Junyou very high profit
With value.There are anti-corrosion, antibacterial, strengthen neural, antipyretic, promotion digestion, protection stomach, anti-inflammatory and adjust immune and other effects.Rat-tail
The water extract and alcohol extract of blade of grass are effective, multi-functional natural and free radical scavenger.
The thymy alcohol extract of thyme extract or water extract, preferably Chinese medicine thyme are by washing, dry, powder
It is broken, water carry or alcohol extracting after concentrate, liquid spray is dried, thyme extract powder is made.Thyme extract has preferably
Antifungal activity also has certain anti-inflammatory effect.There is certain antibacterial work to bacterium common in food, saccharomycete and mould
With.Fungicide and preservative be can be used as to use.
Mulberry-leaf extract is the alcohol extract or water extract of mulberry leaf, and preferably Chinese medicine mulberry leaf are by washing, dry, crushing, water
Carry or alcohol extracting after concentrate, liquid spray is dried, mulberry-leaf extract powder is made.The main chemical compositions of mulberry leaf have flavanone
Class, flavonoid glycoside, alkaloids, polysaccharide, sterols, volatile oil and vitamin.Pharmaceutical research shows that mulberry leaf have drop blood
The effects that sugar, reducing blood lipid, antitumor, anti-oxidant, strengthen immunity, anti-inflammatory, antibacterial, antiviral, anticoagulation and expansion blood vessel, mulberry leaf
Extract has the function of stronger inhibition oral cavity common pathogen.
Chrysanthemum extract is the alcohol extract or water extract of chrysanthemum, preferably chrysanthemum by washing, it is dry, crush, water carry or
It is concentrated after alcohol extracting, liquid spray is dried, chrysanthemum extract powder is made.Chrysanthemum has anti-as China's tradition conventional Chinese medicine
The multiple pharmacological effects such as bacterium, anti-inflammatory, anti-oxidant, vasodilator, reducing blood lipid, antitumor, drive lead.In addition, studies have found that.Wild chrysanthemum
(dry capitulum of feverfew mother chrysanthemum Ghrysanthemum indicum L.) has broad-spectrum antiseptic, antiviral, releasing
The pharmacological actions such as oxygen radical, antiallergic action.The chemical composition of wild chrysanthemum mainly has flavones, terpene and volatile oil, and contains
Polysaccharide, protein, amino acid, chlorophyll, vitamin, alantol, yejuhua lactone, various trace elements.Flavones, terpene and volatilization
The ingredients such as oil have antibacterial, anti-inflammatory, antiviral, anti-oxidant and immunoregulation effect, to staphylococcus aureus, green pus bar
Bacterium, corynebacterium diphtheriae, streptococcus, shigella dysenteriae, escherichia coli, typhoid bacillus, influenza virus have inhibiting effect.Chlorophyll can press down
Bacterium is sterilized, and oral peculiar smell, fresh breath are removed.
Kudzu root extract is the alcohol extract or water extract of pueraria lobata, and preferably Chinese medicament kudzu-vine root passes through washing, dry, crushing,
Water carry or alcohol extracting after concentrate, liquid spray is dried, kudzu root extract powder is made.The active ingredient of pueraria lobata is mainly isoflavones
Class, pueraria lobata saponins.Isoflavone compound is also its principle active component, can be subdivided into two class of glycosides and aglycon.The former includes
Puerarin, daidzin, genistin etc.；The latter refers mainly to daidzein, genistein, coumestrol and isoliquiritigenin etc..Its
In, Puerarin have various biological effect, such as neuroprotection, improve immunity, enhance myocardial contractive power, anti-oxidation stress,
Anti-inflammatory, antiallergy, improvement microcirculation etc.
Bupleurum extract is the alcohol extract or water extract of radix bupleuri, and preferably bupleurum Chinese is by washing, dry, crushing, water
Carry or alcohol extracting after concentrate, liquid spray is dried, bupleurum extract powder is made.Radix bupleuri has significant anti-inflammatory effect, radix bupleuri
Anti-inflammatory active ingredient is saikoside.Saikoside includes inflammatory exudation, capillary permeability liter to inflammation process
Height, inflammatory mediator release, leukoplania and connective tissue proliferation etc. have inhibiting effect.Radix bupleuri also there is immunological regulation to make
With, antitumor action, sedation, relaxation vascular smooth muscle, improve abdominal viscera blood flow, to the effect etc. of digestive system；Bavin
Prescription is often formed with other medicines in ease pain recklessly or is stopped for soothing liver-gallbladder, spasmolysis and analgesia, or for regulating qi-flowing for harmonizing stomach, promoting blood circulation
Bitterly.
Baical Skullcap root P.E is the alcohol extract or water extract of radix scutellariae, and preferably baikal skullcap root is by washing, dry, crushing, water
Carry or alcohol extracting after concentrate, liquid spray is dried, Baical Skullcap root P.E powder is made.Radix scutellariae is containing baicalein, scutelloside, Chinese radix scutellariae
Element, wogonoside, neobaicalein, acetophenone, palmitic acid, oleic acid, proline, benzoic acid, baicalinase, cupreol.Modern times grind
Study carefully and shows radix scutellariae to hemolytic streptococcus, Diplococcus pneumopniae, influenza virus, typhoid bacillus, shigella dysenteriae, Pseudomonas aeruginosa, tuberculosis
Bacillus, staphylococcus aureus have inhibiting effect.Scutelloside has hemostasis, anti-inflammatory as the draft additive of toothpaste, except halitosis and
A variety of curative effects such as callus.
Coptis extract is the alcohol extract or water extract of the coptis, and preferably Chinese Drug Rhizomes of Coptis is by washing, dry, crushing, water
Carry or alcohol extracting after concentrate, liquid spray is dried, coptis extract powder is made.The coptis is ranunculaceae plant coptis Coptis
Chinensis Franch., triangle leaf coptis Coptis deltoidea C.Y.Cheng et Hsiao or cloud connect Coptis
The dry rhizome of teeta Wall..The coptis mainly has many-sided effect such as antibacterial, antiviral, antiendotoxin, antiprotozoan, can
To inhibit.Jamaicin in the coptis has inhibiting effect to a variety of Grain-positives and negative bacterium.Berberine is in vitro to deep and remote
Helicobacter pylori has obvious inhibiting effect, cheap, and safety is good.
Andrographis Paniculata is the alcohol extract or water extract of Herba Andrographitis, and preferably Chinese medicine Herba Andrographitis is by washing, dry, powder
It is broken, water carry or alcohol extracting after concentrate, liquid spray is dried, Andrographis Paniculata powder is made.Chinese Pharmacopoeia》Version one in 2015
Its cold in nature, bitter is recorded, there is the effect of clearing heat and detoxicating, cool blood, detumescence.For cold, fever, abscess of throat, aphthae,
Pertussis overstrain cough, dysentery, puckery pain of heat gonorrhea, carbuncle swells sore, snakebite and bugbite.Main component is lactone and Huang in Andrographis Paniculata
Ketone, active ingredient are mainly lactone, there is good clearing heat and anti-inflammatory functions, are known as the good reputation of " Chinese medicine antibacterial element ".Modern pharmacology
It learns studies have shown that andrographolide has anti-inflammatory, antitumor, antiviral, anti-oxidant, immunological regulation and Hepatocyte protection.There is reality
Verification is real, and Andrographis Paniculata can treat canker sore.
Honegsukle flower P.E is the alcohol extract or water extract of honeysuckle, and preferably Flos lonicerae is by washing, dry, powder
It is broken, water carry or alcohol extracting after concentrate, liquid spray is dried, Honegsukle flower P.E powder is made.Honeysuckle flower water or ethanol extract
Include mainly anti-inflammatory, antipyretic, antibacterial, antiviral, antimycotic, antiendotoxin, decompression, guarantor with relatively broad pharmacological action
Liver cholagogic, antifertility, anti-oxidant, hemostasis and immunological regulation etc..Honeysuckle plays clearing heat and removing internal heat, anti-inflammatory analgetic and is removed in toothpaste
Halitosis acts on.
Dandelion extract is the alcohol extract or water extract of dandelion, preferably washed by Chinese traditional drug taraxacum herb process, is dry,
Crush, water carry or alcohol extracting after concentrate, liquid spray is dried, dandelion extract powder is made.Dandelion is broad spectrum antimicrobial agent,
With antimycotic, antiviral, anti-inflammatory, anti-oxidant, antitumor, hepatic cholagogic, protection stomach and intestine, blood glucose, improve vascular function, immune
It adjusts, fatigue-resisting function.It can inhibit the growth of oral cavity Hp in the oral cavity, treatment recurrent oral ulceration, remove halitosis；Clothes
With gastric and duodenal ulcer etc. can be treated.
The wooden sodium azulenesulfonate is prepared by modification on the molecular structure of Kessazulen.The sodium azulenesulfonate tool
There are fabulous anti-inflammatory, antibacterial, antiallergy and the effect for promoting regeneration, the healing of empyrosis wound surface, ulcer wound surface can be promoted
It is regenerated with granulation, while there are a variety of effects such as solar heat protection, radiation protection, anti-chap, can be used to treat various diseases, it is safe,
Therefore it is widely used in various pharmaceutical preparations, and the especially treatment and prevention to skin and mouth disease, significant effect.
As the preferred technical solution of the present invention, a kind of composition is provided, it is composed of the following components：
0.1-0.8 parts of narrow leaved tea tree essential oil,
0.2-0.8 parts of Arnica extract；
Or,
Composition described in any of the above-described technical solution provided by the present invention all has good hemostasis, antibacterial work
With.
The present invention also provides the compositions described in an any of the above-described technical solution to prepare treatment bleeding gums, inhibit mouth
The drug of chamber bacterium or the application in oral care product.Wherein, the oral care product includes toothpaste, mouthwash, tooth powder, oral cavity
Spraying, oral cavity ointment etc..
The drug or oral care product are using above-mentioned any one technical solution resulting composition as active component.
Specifically, the present invention provides a kind of toothpaste, includes the component of following parts by weight：
Active component：
Narrow leaved tea tree essential oil 0.01-2 parts by weight；
Arnica extract 0.02-5 parts by weight；
Auxiliary material：
Preferably, the toothpaste includes the component of following parts by weight：
Active component：
Narrow leaved tea tree essential oil 0.05-1 parts by weight；
Arnica extract 0.08-3 parts by weight；
Auxiliary material：
The rubbing agent is selected from silica, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, chlorination
One or more of sodium or calcium pyrophosphate；
The moisturizer is selected from sorb (sugar) alcohol, glycerine, propylene glycol, polyethylene glycol-8 or one kind or several in butanediol
Kind；
The foaming agent is selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid
One or more of sodium or cocounut oil acyl methyl taurine sodium；
The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar gum hydroxypropyl three
One or more of ammonio methacrylate, carrageenan or locust tree fresh kidney beans；
The sweetener is selected from saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside or sweet Momordica grosvenori
One or more of glycosides；
The essence is selected from one or more of vanilla, spearmint, minty note or Chinese ilex peppermint；
The one kind or several of the preservative in benzoic acid and its esters, sorbic acid and its esters or parabens
Kind；
The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake or one or more of the particle that cleans the teeth；
The solvent is selected from deionized water.
Preferably, the active component of the toothpaste further includes any one or a few following ingredient：
As the preferred technical solution of the present invention, a kind of toothpaste is provided, total weight parts are 100 parts, composed of the following components：
Or,
Toothpaste provided by the present invention can significantly reduce oral bacteria quantity, and it is largely effective to treat sensitivity of tooth.
The present invention also provides a kind of preparation methods of above-mentioned toothpaste, including：Above-mentioned active component (composition) is mixed, system
Obtain toothpaste.
The preparation method of the toothpaste is specific as follows：
A, the active component is dissolved in moisturizer, high-speed stirred, is prepared into the first mixed liquor；
B, thickener is added in the first mixed liquor, stirring obtains the second mixed liquor；
C, appearance modifying agents are added into the second mixed liquor, stirs, obtains third mixed liquor；
D, third mixed liquor, sweetener, rubbing agent, essence, foaming agent, preservative are added into solvent, stirring obtains the
Four mixed liquors；
E. the 4th mixed liquor continues to stir at vacuum condition 0.08-0.12MPa, and lotion is made；
F. it examines, sterile filling enters in aluminum plastic composite pipe, and toothpaste is made in sealing.
The present invention also provides a kind of mouthwashes, include the component of following parts by weight：
Active component：
Narrow leaved tea tree essential oil 0.01-2 parts by weight；
Arnica extract 0.02-5 parts by weight；
Auxiliary material：
The solvent is selected from deionized water；
The moisturizer is selected from one or more of sorb (sugar) alcohol, propylene glycol, glycerine, polyethylene glycol-8；
The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl first
One or more of base sodium taurocholate；
The thickener is selected from one or more of cellulose, card wave, carragheen；
The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex
One or more of peppermint；
The colorant is selected from one or more of green, blue, red.
It is furthermore preferred that the active component of above-mentioned mouthwash further includes following ingredient：
Technical solution of the present invention has the advantages that：
The present invention gives full play to the synergistic function between each ingredient so that institute using the different medical mechanism of each ingredient
Composition can prevent and formation that plaque can be inhibited while co-treatment sensitivity of tooth.And materials safety, it fits
Preferably produce.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Narrow leaved tea tree essential oil 0.01,
Arnica extract 3.
Embodiment 2
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Narrow leaved tea tree essential oil 0.5,
Arnica extract 0.8.
Embodiment 3
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Narrow leaved tea tree essential oil 1,
Arnica extract 5.
Embodiment 4
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Narrow leaved tea tree essential oil 2,
Arnica extract 0.02.
Embodiment 5
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Embodiment 6
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Embodiment 7
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Embodiment 8
The present embodiment provides a kind of compositions, and by weight, formula is as follows：
Embodiment 9
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 10
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 11
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 12
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 13
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 14
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 15
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 16
The present embodiment provides a kind of toothpaste, total weight parts are 100 parts, and formula is as follows：
Embodiment 17
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 18
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 19
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 20
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 21
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 22
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Embodiment 23
The present embodiment provides a kind of mouthwash, total weight parts are 100 parts, and formula is as follows：
Comparative example 1-5
Comparative example 1-5 provides a kind of composition respectively, and by weight, formula is as follows：
Comparative example 6-10
Comparative example 6-10 provides a kind of composition respectively, and by weight, formula is as follows：
Comparative example 11-14
Comparative example 11-14 provides a kind of toothpaste respectively, and total weight parts are 100 parts, and formula is as follows：
Comparative example 15-19
Comparative example 15-19 provides a kind of toothpaste respectively, and total weight parts are 100 parts, and formula is as follows：
Comparative example 20
This comparative example provides that a kind of (preparation method is according to this field routine operation containing 3.8% strontium chloride sterile liquid
Can).
Comparative example 21
This comparative example provides a kind of certain commercially available toothpaste containing 3.8% strontium chloride, the effect of the mitigation sensitivity of tooth of the toothpaste
It has been gained public acceptance that, be optimal one of the toothpaste of current antiallergic effect.
Test example 1
This test example provides the antibacterial examination for the composition that the composition that embodiment 1-4 is provided and comparative example 1-5 are provided
It tests.
Subjects：The sterile molten of same concentrations is respectively prepared in embodiment 1-4, comparative example the 1-5 composition provided
Liquid.(preparation method is according to this field routine operation)
Test method：
Choose the following strain being present in oral cavity：Helicobacter pylori, gold-coloured staphylococci, Candida albicans, deformation
Streptococcus；Choose caseinhydrolysate (MH) meat soup, agar medium.
Standard strain takes the strain of a ring to be inoculated in 37 in MH broth bouillons with oese respectively after passing on pure culture
DEG C constant incubator culture identifies bacterium amount through turbidimetry and counts for 6 hours.The different experiments of equal amount culture 6 hours are taken respectively
Bacterium solution is spread evenly across MH agar plate surfaces by bacterium solution respectively with sterile cotton swab, is drawn respectively with aseptic nipper after slightly dry
The circle filter paper of the sterile liquid of equivalent comparative example 1~5, comparative example 20 and Examples 1 to 4, note is in MH agar plate surfaces, 37 DEG C
Antibacterial circle diameter (mm) is observed and measured to insulating box culture in 24 hours, and bacteriostatic experiment is repeated 3 times, and antibacterial result is that 3 experiments are flat
Mean value obtains 1 result of table.
Test result：
Table 1
The MH broth bouillons containing equivalent comparative example 1~5, comparative example 20 and Examples 1 to 4 sterile solution are taken, respectively
It is inoculated with the test bacteria liquid 0.05ml (10 of the different strain of equivalent5CFU/ml), and with sterile MH broth bouillons it is inoculated with identical bacterium
Kind as a contrast, the result such as table 2 is obtained after 24 hours in 37 DEG C of insulating box cultures.
Table 2
" +++ " bacterium obviously grows；"+" bacterium reduces growth；" 0 " takes culture medium in inoculation asepsis growth.
According to table 2 it is found that narrow leaved tea tree essential oil is substituted for combination of the triclosan fungistatic effect less than the present invention.This
Outside, document confirm narrow leaved tea tree essential oil orally repeatedly contact when be it is safe, no mutagenesis risk and without cause chromosome
Distort risk, nonirritant to mucous membrane of mouth and gum film when applied to the product for being used for oral cavity, therefore can be used safely in toothpaste
In equal oral care products.And triclosan has lipophilicity, can accumulate in vivo for a long time, has potential threat, at present
Having lot of documents to probe into triclosan, there may be poisonous effects to biology.Therefore Western medicine is avoided using narrow leaved tea tree essential oil
The side effect of ingredient triclosan meets the trend of special acting type oral care product back to nature.
Test example 2
This test example provides the biocidal property experiment of embodiment 5-8, the composition that comparative example 6-10 is provided.
Subjects：The sterile molten of same concentrations is respectively prepared in embodiment 5-8, comparative example the 6-10 composition provided
Liquid.(preparation method is according to this field routine operation)
Test method：
Choose following strain present in oral cavity：Helicobacter pylori, gold-coloured staphylococci, Candida albicans, deformation chain
Coccus；Choose caseinhydrolysate (MH) meat soup, agar medium.
Standard strain takes the strain of a ring to be inoculated in 37 in MH broth bouillons with oese respectively after passing on pure culture
DEG C constant incubator culture identifies bacterium amount through turbidimetry and counts for 6 hours.The different experiments of equal amount culture 6 hours are taken respectively
Bacterium solution is spread evenly across MH agar plate surfaces by bacterium solution respectively with sterile cotton swab, is drawn respectively with aseptic nipper after slightly dry
The circle filter paper of the sterile liquid of equivalent comparative example 6~10 and embodiment 5~8, note is in MH agar plate surfaces, 37 DEG C of insulating box trainings
It supports 24 hours and observes and measure antibacterial circle diameter (mm), bacteriostatic experiment is repeated 3 times, and antibacterial result is 3 laboratory mean values, is obtained
3 result of table.
Test result：
Table 3
The MH broth bouillons containing 5~8 sterile solution of equivalent comparative example 6~10 and embodiment are taken, are inoculated with equivalent respectively
Different strain test bacteria liquid 0.05ml (105CFU/ml), and using sterile MH broth bouillons be inoculated with identical strain as pair
According to being obtained such as 4 result of table after 24 hours in 37 DEG C of insulating box cultures.
Table 4
" +++ " bacterium obviously grows；"+" bacterium reduces growth；" 0 " is culture medium asepsis growth.
The above results are it is found that further add medicine Salvia japonica, Moschus leaf extract, mulberry leaf, chrysanthemum, pueraria lobata, radix bupleuri, Huang
One or more of a kind of reed mentioned in ancient books, the coptis, Herba Andrographitis, honeysuckle, dandelion, wooden sodium azulenesulfonate, can be such that the present invention of gained obtains
More significant effect, i.e. medicine Salvia japonica, Moschus leaf extract, mulberry leaf, chrysanthemum, pueraria lobata, radix bupleuri, radix scutellariae, the coptis, punching
One or more of lotus, honeysuckle, dandelion, wooden sodium azulenesulfonate and the combination being made of narrow leaved tea tree essential oil, Arnica
There is synergistic function between object.
Test example 3
Verification experimental verification of the toothpaste that this test example provides embodiment 9-12, comparative example 11-14 is provided to sensitivity of tooth.
The inclusion criteria of subjects is：Between age 18-65 Sui, remaining tooth >=16 tooth in mouth, no systemic disease, merely
Property sensitivity of tooth crowd, such crowd is when tooth is by the stimulation of hot and cold, sour, sweet tea and mechanicalness effect (friction, sting hard object)
When, can generate and ache feelings suddenly, or flash across or of short duration lasting, after stimulation removal, it is this ache sympathetic can disappear.
Experimental subjects participates in the normal individual trial experiment of toothpaste, is grouped at random according to test specimen number, every group of 25 people, each group makes respectively
With the toothpaste in embodiment and comparative example, daily sooner or later respectively using once, 10d is as a treatment course, total 20d, i.e. two courses for the treatment of.
The criterion of the effect of test effect is as follows：
It is effective：Sensitivity of tooth is controlled after two courses for the treatment of, and no relapse after 20d.
Effectively：Sensitivity of tooth is obviously improved, and the degree for sensitivity of tooth occur is considerably less than using before experiment toothpaste.
In vain：Sensitivity of tooth degree is not improved.
Treat total effective rate=(effective+effective)/total number of cases × 100%.
The results are shown in Table 5.
Table 5
Test example 4
The toothpaste that this test example offer embodiment 13-16, comparative example 15-19, comparative example 21 are provided is to sensitivity of tooth
Verification experimental verification.
The inclusion criteria of subjects is：Between age 18-65 Sui, remaining tooth >=16 tooth in mouth, no systemic disease, merely
Property sensitivity of tooth crowd, such crowd is when tooth is by the stimulation of hot and cold, sour, sweet tea and mechanicalness effect (friction, sting hard object)
When, can generate and ache feelings suddenly, or flash across or of short duration lasting, after stimulation removal, it is this ache sympathetic can disappear.
Experimental subjects participates in the normal individual trial experiment of toothpaste, is grouped at random according to test specimen number, every group of 25 people, each group makes respectively
With the toothpaste in embodiment and comparative example, daily sooner or later respectively using once, 10d is as a treatment course, total 20d, i.e. two courses for the treatment of.
The criterion of the effect of test effect is as follows：Curative effect determinate standard is as follows：
It is effective：Sensitivity of tooth is controlled after two courses for the treatment of, and no relapse after two weeks.
Effectively：Sensitivity of tooth is obviously improved, and the degree for sensitivity of tooth occur is considerably less than using before experiment toothpaste.
In vain：Sensitivity of tooth degree is not improved.
Treat total effective rate=(effective+effective)/total number of cases × 100%.
The results are shown in Table 6.
Table 6
The antiallergic effect of comparative example 21 is suitable with embodiment 14 provided by the invention, but the toothpaste that comparative example 21 is provided
In contain strontium chloride.Strontium chloride is a kind of common salt, but this field knows, strontium chloride category lower toxicity, slightly irritation.It need to keep away
Contact-free eye, mouth avoid sucking.So while the additive amount only 3.8% in comparative example 19, still falls within hypotoxicity product.But this
Inventive composition be natural botanical source at being grouped as, green, natural safety has no toxic side effect.
Although above having used general explanation, specific implementation mode and experiment, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (10)
1. a kind of composition, which is characterized in that by weight, including：
Narrow leaved tea tree essential oil 0.01-2 parts by weight；
Arnica 0.02-5 parts by weight.
2. composition according to claim 1, which is characterized in that including：
Narrow leaved tea tree essential oil 0.05-1 parts by weight；
Arnica 0.08-3 parts by weight.
3. composition according to claim 1 or 2, which is characterized in that the composition further includes selected from medicine Salvia japonica, musk deer
In vanilla leaf extract, mulberry leaf, chrysanthemum, pueraria lobata, radix bupleuri, radix scutellariae, the coptis, Herba Andrographitis, honeysuckle, dandelion, the wooden sodium azulenesulfonate
One or more；
Preferably, medicine Salvia japonica 0.05-2 parts by weight, thyme 0.01-1 parts by weight, mulberry leaf 0.5-5 parts by weight, chrysanthemum are selected from
0.01-2 parts by weight, pueraria lobata 0.05-2 parts by weight, radix bupleuri 0.05-2 parts by weight, radix scutellariae 0.02-5 parts by weight, coptis 0.02-4 weights
Measure part, Herba Andrographitis 0.5-5 parts by weight, honeysuckle 0.05-6 parts by weight, dandelion 0.01-2 parts by weight, the wooden sodium azulenesulfonate 0.005-
One or more of 2 parts by weight.
4. according to claim 1-3 any one of them compositions, which is characterized in that the composition include medicine Salvia japonica,
Moschus leaf extract, mulberry leaf, chrysanthemum, pueraria lobata, radix bupleuri, radix scutellariae, the coptis, Herba Andrographitis, honeysuckle, dandelion, the wooden sodium azulenesulfonate；
Preferably, the composition includes：
5. claim 1-4 any one of them composition is in the drug or mouth for preparing treatment bleeding gums, inhibiting oral bacteria
Application in chamber nursing product；
Preferably, the oral care product includes toothpaste, mouthwash, tooth powder, mouthspray, oral cavity ointment.
6. a kind of toothpaste, which is characterized in that including composition according to any one of claims 1-4 as active component.
7. toothpaste according to claim 6, which is characterized in that the toothpaste further includes：
Preferably, the rubbing agent be selected from silica, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide,
One or more of sodium chloride or calcium pyrophosphate；
The moisturizer is selected from one or more of D-sorbite, glycerine, propylene glycol, polyethylene glycol-8 or butanediol；
The foaming agent be selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid sodium or
One or more of cocounut oil acyl methyl taurine sodium；
The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar hydroxypropyltrimonium
One or more of ammonium chloride, carrageenan or locust tree fresh kidney beans；
The sweetener is in saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside or mogroside
One or more；
The essence is selected from one or more of vanilla, spearmint, minty note or Chinese ilex peppermint；
The preservative is selected from benzoic acid and its esters, sorbic acid and one or more of its esters or parabens；
The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake or one or more of the particle that cleans the teeth；
The solvent is selected from deionized water.
8. a kind of method preparing the toothpaste described in claim 6 or 7, which is characterized in that include the following steps：
A, the active component is dissolved in moisturizer, high-speed stirred, is prepared into the first mixed liquor；
B, thickener is added in the first mixed liquor, stirring obtains the second mixed liquor；
C, appearance modifying agents are added into the second mixed liquor, stirs, obtains third mixed liquor；
D, third mixed liquor, sweetener, rubbing agent, essence, foaming agent, preservative are added into solvent, it is mixed to obtain the 4th for stirring
Close liquid；
E, the 4th mixed liquor continues to stir at vacuum condition 0.08-0.12MPa, and lotion is made.
9. a kind of mouthwash, which is characterized in that including composition according to any one of claims 1-4 as active component.
10. mouthwash according to claim 9, which is characterized in that the mouthwash further includes：
Preferably, the solvent is selected from deionized water；
The moisturizer is selected from one or more of D-sorbite, propylene glycol, glycerine, polyethylene glycol-8；
The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl methyl ox
One or more of sodium sulfonate；
The thickener is selected from one or more of cellulose, card wave, carragheen；
The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex peppermint
One or more of；
The colorant is selected from one or more of green, blue, red.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810210198.4A CN108606939B (en) | 2018-03-14 | 2018-03-14 | Composition with oral health care function and application and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810210198.4A CN108606939B (en) | 2018-03-14 | 2018-03-14 | Composition with oral health care function and application and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108606939A true CN108606939A (en) | 2018-10-02 |
| CN108606939B CN108606939B (en) | 2020-07-07 |
Family
ID=63658853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810210198.4A Active CN108606939B (en) | 2018-03-14 | 2018-03-14 | Composition with oral health care function and application and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108606939B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846786A (en) * | 2019-03-25 | 2019-06-07 | 浙江省中医院 | A kind of Chinese medicine mouth wash and the preparation method and application thereof |
| CN110478298A (en) * | 2019-09-23 | 2019-11-22 | 沈阳天然纳美科技有限公司 | A kind of composition and its preparation method and application with oral health function |
| CN112691057A (en) * | 2020-12-23 | 2021-04-23 | 中国热带农业科学院热带作物品种资源研究所 | Compound functional toothpaste and preparation method thereof |
| CN113197812A (en) * | 2021-06-17 | 2021-08-03 | 湖北仙之灵食品有限公司 | Production process of toothpaste with tooth cleaning, anti-inflammatory and bactericidal functions |
| CN113491660A (en) * | 2021-08-24 | 2021-10-12 | 厦门恒新万鼎电子科技有限公司 | Chinese herbal medicine mouthwash and preparation method thereof |
| CN114469761A (en) * | 2021-12-28 | 2022-05-13 | 彭氏(惠州)实业发展有限公司 | Oral care compositions and methods of use and preparation thereof |
| CN115778833A (en) * | 2022-11-17 | 2023-03-14 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | Tooth whitening oral care composition |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183762B1 (en) * | 1997-05-27 | 2001-02-06 | Sembiosys Genetics Inc. | Oil body based personal care products |
| CN1599594A (en) * | 2001-11-06 | 2005-03-23 | 博费蒂·迈·麦勒有限公司 | Solid oral compositions |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN106606439A (en) * | 2015-10-20 | 2017-05-03 | 青岛益邦瑞达生物科技有限公司 | Toothpaste composition |
| CN107669592A (en) * | 2017-11-03 | 2018-02-09 | 司彦霞 | Promoting and tooth-building toothpaste |
-
2018
- 2018-03-14 CN CN201810210198.4A patent/CN108606939B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183762B1 (en) * | 1997-05-27 | 2001-02-06 | Sembiosys Genetics Inc. | Oil body based personal care products |
| CN1599594A (en) * | 2001-11-06 | 2005-03-23 | 博费蒂·迈·麦勒有限公司 | Solid oral compositions |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
| CN106606439A (en) * | 2015-10-20 | 2017-05-03 | 青岛益邦瑞达生物科技有限公司 | Toothpaste composition |
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
| CN107669592A (en) * | 2017-11-03 | 2018-02-09 | 司彦霞 | Promoting and tooth-building toothpaste |
Non-Patent Citations (2)
| Title |
|---|
| 秦太峰等: "《天然香料资源开发与利用》", 30 September 2011, 中国农业科学技术出版社 * |
| 颜红侠等: "《日用化妆品制造原理与技术》", 31 July 2004, 化学工业出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846786A (en) * | 2019-03-25 | 2019-06-07 | 浙江省中医院 | A kind of Chinese medicine mouth wash and the preparation method and application thereof |
| CN110478298A (en) * | 2019-09-23 | 2019-11-22 | 沈阳天然纳美科技有限公司 | A kind of composition and its preparation method and application with oral health function |
| CN112691057A (en) * | 2020-12-23 | 2021-04-23 | 中国热带农业科学院热带作物品种资源研究所 | Compound functional toothpaste and preparation method thereof |
| CN112691057B (en) * | 2020-12-23 | 2023-04-21 | 中国热带农业科学院热带作物品种资源研究所 | Compound efficacy toothpaste and preparation method thereof |
| CN113197812A (en) * | 2021-06-17 | 2021-08-03 | 湖北仙之灵食品有限公司 | Production process of toothpaste with tooth cleaning, anti-inflammatory and bactericidal functions |
| CN113491660A (en) * | 2021-08-24 | 2021-10-12 | 厦门恒新万鼎电子科技有限公司 | Chinese herbal medicine mouthwash and preparation method thereof |
| CN114469761A (en) * | 2021-12-28 | 2022-05-13 | 彭氏(惠州)实业发展有限公司 | Oral care compositions and methods of use and preparation thereof |
| CN115778833A (en) * | 2022-11-17 | 2023-03-14 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | Tooth whitening oral care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108606939B (en) | 2020-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108606939A (en) | A kind of composition and its application and preparation method with oral health function | |
| TW201141496A (en) | Oral compositions containing a combination of natural extracts and related methods | |
| CN108464963B (en) | Composition for oral cavity and application and preparation method thereof | |
| CN108464956B (en) | Composition applied to oral cavity and preparation method and application thereof | |
| CN108392521A (en) | A kind of mouth sprays and preparation method thereof | |
| CN105534805B (en) | A kind of Chinese herbal toothpaste of antibacterial anti hemorrhagic | |
| CN109223663A (en) | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis | |
| CN101147724A (en) | Medicine or sanitary product containing licorice flavone extraction for oral cavity | |
| CN104435379A (en) | Plant extract compound capable of inhibiting bacteria, resisting inflammation, stopping bleeding and relieving pain and application of plant extract compound | |
| CN108042420B (en) | Composition for oral health care and application thereof | |
| CN107929428B (en) | Composition for oral cavity and application thereof | |
| KR101778058B1 (en) | Composition for sanitation promotion of oral cavity comprising natural medicinal ingredient extract as effective component for halitosis inducing microoranism and infectious disease of mucous membrane | |
| CN108478500B (en) | Composition for oral cavity and application thereof | |
| CN106511423A (en) | Application of annual fleabane herb extract in preparation of mouth care health product | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| CN108066224A (en) | A kind of peace stomach ulcer toothpaste and preparation method thereof | |
| CN113520957A (en) | Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and preparation method thereof | |
| CN113332342A (en) | Traditional Chinese medicine extract for resisting oral helicobacter pylori, oral care product and preparation method thereof | |
| Mahant et al. | Home remedies for dental diseases in the Pandemic of COVID-19-A Systematic Review | |
| CN113768855B (en) | Antibacterial composition, antibacterial preparation, and preparation method and application thereof | |
| CN110151636A (en) | A kind of mouth cleaning solution and preparation method thereof | |
| RU2618889C1 (en) | Mouthwash agent having antiinflammatory, antimicrobial, wound-healing effect | |
| KR101932681B1 (en) | Composition for inhibiting halitosis | |
| CN110013452A (en) | Permanent tooth shield gum is cured the Chinese medicine compound prescription toothpaste and preparation method thereof of ulcer and dark hair | |
| CN114146125B (en) | Traditional Chinese medicine composition for inhibiting helicobacter pylori infection in oral cavity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |