CN115778833A - Tooth whitening oral care composition - Google Patents
Tooth whitening oral care composition Download PDFInfo
- Publication number
- CN115778833A CN115778833A CN202211460640.1A CN202211460640A CN115778833A CN 115778833 A CN115778833 A CN 115778833A CN 202211460640 A CN202211460640 A CN 202211460640A CN 115778833 A CN115778833 A CN 115778833A
- Authority
- CN
- China
- Prior art keywords
- percent
- oral care
- care composition
- tooth whitening
- berberine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 230000002087 whitening effect Effects 0.000 title claims abstract description 55
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229940093265 berberine Drugs 0.000 claims abstract description 36
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000004094 surface-active agent Substances 0.000 claims abstract description 21
- 229940034610 toothpaste Drugs 0.000 claims abstract description 19
- 239000000606 toothpaste Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 12
- 229920000642 polymer Polymers 0.000 claims abstract description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 6
- 150000007942 carboxylates Chemical class 0.000 claims abstract description 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 62
- -1 methyl taurate Chemical compound 0.000 claims description 26
- 239000002994 raw material Substances 0.000 claims description 25
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- 235000011187 glycerol Nutrition 0.000 claims description 24
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 14
- 239000000600 sorbitol Substances 0.000 claims description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 13
- 229920002125 Sokalan® Polymers 0.000 claims description 13
- 229960001631 carbomer Drugs 0.000 claims description 13
- 239000003906 humectant Substances 0.000 claims description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 13
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 10
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 239000002324 mouth wash Substances 0.000 claims description 10
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 10
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 10
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 8
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 8
- 229940051866 mouthwash Drugs 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 239000000230 xanthan gum Substances 0.000 claims description 8
- 235000010493 xanthan gum Nutrition 0.000 claims description 8
- 229920001285 xanthan gum Polymers 0.000 claims description 8
- 229940082509 xanthan gum Drugs 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 229920001400 block copolymer Polymers 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 229920001451 polypropylene glycol Polymers 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 6
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 6
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 6
- 229930182470 glycoside Natural products 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 6
- 108700004121 sarkosyl Proteins 0.000 claims description 6
- 229960004029 silicic acid Drugs 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 229940083542 sodium Drugs 0.000 claims description 6
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 6
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 6
- 229940104261 taurate Drugs 0.000 claims description 6
- 239000001069 triethyl citrate Substances 0.000 claims description 6
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013769 triethyl citrate Nutrition 0.000 claims description 6
- 125000000129 anionic group Chemical group 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 4
- 239000012752 auxiliary agent Substances 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 239000000665 guar gum Substances 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- 229960002154 guar gum Drugs 0.000 claims description 4
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 22
- 239000000499 gel Substances 0.000 abstract description 10
- 150000001450 anions Chemical class 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 abstract description 2
- 230000036344 tooth staining Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 26
- 239000004376 Sucralose Substances 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 16
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 16
- 235000010234 sodium benzoate Nutrition 0.000 description 16
- 239000004299 sodium benzoate Substances 0.000 description 16
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 16
- 235000019408 sucralose Nutrition 0.000 description 16
- 239000000654 additive Substances 0.000 description 13
- 230000000996 additive effect Effects 0.000 description 13
- 239000003504 photosensitizing agent Substances 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 7
- 150000002978 peroxides Chemical class 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000003642 reactive oxygen metabolite Substances 0.000 description 5
- 238000010186 staining Methods 0.000 description 5
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 230000007794 irritation Effects 0.000 description 3
- 238000002428 photodynamic therapy Methods 0.000 description 3
- 229960000502 poloxamer Drugs 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 150000003836 berberines Chemical group 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 239000013522 chelant Substances 0.000 description 2
- 230000005281 excited state Effects 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940095688 toothpaste product Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Abstract
The invention discloses a tooth whitening oral care composition. The tooth whitening oral care composition contains 0.01-2% of berberine and an anion material with the berberine content being 2-10 times of that of the berberine by mass percent, wherein the anion material is a polymer and a surfactant containing one or more groups of carboxylate, sulfonate and sulfate. The product form of the tooth whitening oral care composition is toothpaste, mouth cleaning water, gel and tooth paste, and other base materials can be added according to the product form. The composition can whiten teeth and inhibit dental plaque, and does not cause tooth staining.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to a tooth whitening oral care composition.
Background
With the continuous improvement of living standard of people, people pay more and more attention to the health of oral cavity, and the demand of whitening and stain removing oral care products is also increasing. The oral care products on the market at present mainly adopt the following methods to achieve the tooth whitening effect: (1) a large amount of grinding agents with high friction value are used, and the effects of removing stains and whitening skin are achieved through mechanical friction; (2) the chelate is used, and the effects of stain removal and whitening are achieved through chelation; (3) the peroxide is used to oxidize and bleach the colored substances in the teeth, thereby achieving the whitening effect. However, it is difficult to achieve a desired tooth whitening effect by the method using the abrasive and the chelate compound. Due to the strong oxidizing property of the peroxide, the whitening liquid can effectively bleach colored substances in teeth to achieve an ideal tooth whitening effect, can easily damage enamel on the surface of the teeth to make the teeth sensitive, and has great irritation to soft combinations of gingiva, oral mucosa and the like. Although the side effects of peroxides are reduced by technical means such as controlling the amount of peroxides used and changing the types of peroxides, the inherent irritability of peroxides cannot be overcome.
Photosensitizers (PS) are known to absorb light in the presence of oxygen to generate Reactive Oxygen Species (ROS), which can generate cytotoxicity for sterilization and disinfection. Photosensitizer-based photodynamic therapy (PDT) has been extensively studied and applied in the fields of tumor therapy, inflammation elimination, sterilization, disinfection, and the like. PDT also has begun to attract attention from researchers in the application of tooth whitening. Zhang Lei (adv. Funct. Mater.2021, 2104799) found that the modified porphyrin can improve the ROS generation efficiency, has better tooth whitening and plaque removing effects, and has far less damage to teeth than hydrogen peroxide.
Traditional fluorescent molecules or PS often need to have good quantum generation efficiency under the condition of dilute concentration, and after aggregation, the excited state energy of the traditional fluorescent molecules or PS is often dissipated in a non-radiative form, so that the phenomenon of aggregation-induced fluorescence quenching (ACQ) is commonly presented, and the practical application of the traditional fluorescent molecules or PS is limited. In 2001, professor Tang Benzhong first proposed the concept of "aggregation-induced emission" (AIE). Molecules with AIE properties often exhibit more excellent fluorescence in the aggregated state. PS with AIE properties has attracted increasing attention from researchers. 5363 professor Tang Benzhong (mater. Chem. Front.,2019,3,1454-1461) found berberine derived from natural herbaceous plants, had excellent AIE characteristics, and showed good PDT antibacterial effect. The AIE molecule which is a natural product and has higher safety is expected to be applied to the field of tooth whitening, so that the irritation of a peroxide product to the oral cavity is avoided.
The known photosensitizer is combined with oxygen in an excited state, can generate ROS, and can play a role in sterilizing or whitening teeth. The research shows that the fluorescence intensity and ROS generation efficiency of the berberine are lower in a free state. The patent application discloses an antibacterial hydrogel with aggregation-induced emission characteristics and a preparation method thereof, and discloses that amino acid derivatives and berberine form the hydrogel, so that the antibacterial effect of the berberine can be improved. However, further studies have shown that berberine is very prone to staining teeth, and even berberine forms aggregates that risk staining teeth, which can severely limit the use of berberine in oral products.
Disclosure of Invention
Based on the problems of the prior art, it is an object of the present invention to provide a tooth whitening oral care composition. The composition achieves the tooth whitening effect by adding a certain amount of berberine and anion materials.
The purpose of the invention is realized by the following technical scheme:
the invention provides a tooth whitening oral care composition, which contains 0.01-2% of berberine and an anionic material with the berberine content being 2-10 times of the weight percentage, wherein the anionic material is at least one of a polymer and a surfactant, the polymer is a polymer containing at least one group of carboxylate, sulfonate and sulfate, the surfactant is a surfactant containing at least one group of carboxylate, sulfonate and sulfate, and the balance is a base material.
Further, the product form of the composition is at least one of toothpaste, gel, mouth wash and tooth paste.
Further, the product form of the composition is toothpaste, and the composition comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 10 to 50 percent of grinding agent, 20 to 60 percent of humectant, 0.5 to 5 percent of surfactant, 0.1 to 3 percent of thickening agent, 0.5 to 2 percent of essence and the balance of other additive components.
Further, the tooth whitening oral care composition, when the product form thereof is a toothpaste, the abrasive is selected from at least one of hydrated silica, calcium carbonate, calcium phosphate, calcium hydrogen phosphate, calcium pyrophosphate, aluminum hydroxide, microcrystalline cellulose; the humectant is selected from at least one of sorbitol, glycerol, propylene glycol, ethylene glycol and polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer; the thickening agent is at least one selected from sodium carboxymethylcellulose, xanthan gum, carrageenan, guar gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose.
Further, the other additive components can be at least one of a sweetening agent, a pigment, a preservative, a pH regulator, a traditional Chinese medicine extract, an efficacy additive and water according to the requirements of the toothpaste product.
Further, the product form of the composition is a mouthwash, and the composition comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 5 to 30 percent of humectant, 0.5 to 5 percent of surfactant, 0.2 to 2 percent of essence and the balance of other additive components.
Further, the product form of the composition is a mouthwash, and the composition comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 5 to 30 percent of humectant, 0.4 to 5 percent of surfactant, 0.2 to 2 percent of essence and the balance of other additive components.
Further, the tooth whitening oral care composition, when in the form of a mouthwash, the humectant is selected from at least one of sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer.
Further, other additive components can also be at least one of a sweetener, a pigment, a preservative, a pH regulator, a traditional Chinese medicine extract, an efficacy additive and water according to the requirements of the mouth rinse product.
Further, the product form of the composition is gel, and the gel comprises the following component raw materials in percentage by mass: 0.01 to 2 percent of berberine, 5 to 50 percent of humectant, 0.1 to 4 percent of surfactant, 0.1 to 5 percent of thickening agent, 0.2 to 2 percent of essence and the balance of other additive components.
Further, the tooth whitening oral care composition, when the product form thereof is a gel, the humectant is selected from at least one of sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer; the thickening agent is at least one selected from sodium carboxymethylcellulose, xanthan gum, carrageenan, guar gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose.
Further, the other additive components can be at least one of a sweetening agent, a pigment, a preservative, a pH regulator, a traditional Chinese medicine extract, an efficacy additive and water according to the requirements of the gel product.
Further, the product form of the composition is a tooth paste, and the composition comprises the following component raw materials in percentage by mass: 0.01 to 2 percent of berberine, 60 to 80 percent of film forming agent, 10 to 30 percent of bonding auxiliary agent and the balance of other additive components.
Further, the tooth whitening oral care composition, when the product form thereof is a tooth paste, the film forming agent is selected from at least one of carbomer, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone and polyvinyl alcohol; the bonding auxiliary agent is at least one selected from glycerol, propylene glycol, ethylene glycol, polyethylene glycol and triethyl citrate.
Further, the other additive components can be at least one of a sweetening agent, a pigment, a preservative, a traditional Chinese medicine extract, an efficacy additive and water according to the requirements of the tooth paste product.
Based on the technical scheme, the invention has the following advantages and beneficial effects:
1. when the tooth whitening oral care composition is used, the tooth whitening oral care composition has a better tooth whitening effect under the irradiation of common sunlight or a white light source, and does not cause tooth staining.
2. The berberine in the tooth whitening oral care composition has a broad-spectrum antibacterial effect, has an antibacterial effect on various gram positive and negative bacteria, and has a good antibacterial effect on oral dental plaque.
3. The tooth whitening oral care composition has good safety and small irritation to the oral cavity.
Detailed Description
In order to more fully understand the technical contents of the present invention, the technical solutions will be further described and illustrated with reference to specific embodiments.
The inventor finds that berberine can produce whitening effect when combined with a certain mass proportion of anionic materials, and can not cause staining on teeth. The anion material is a polymer or a surfactant containing one or more of carboxylate, sulfonate and sulfate.
The present invention will be described in further detail with reference to specific examples, but the present invention is not limited to the examples.
Example 1
The product form of the tooth whitening oral care composition is toothpaste, and the mass percentages of the raw material components are as follows:
20% of hydrated silica, 35% of sorbitol, 5% of glycerol, 2% of sodium lauryl sulfate, 1% of cocamidopropyl betaine, 0.2% of sodium carboxymethylcellulose, 0.4% of xanthan gum, 1.5% of essence, 0.5% of berberine, 0.15% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 1
An oral care toothpaste comprises the following raw material components in percentage by mass:
20% of hydrated silica, 35% of sorbitol, 5% of glycerol, 1% of cocamidopropyl betaine, 0.2% of sodium carboxymethylcellulose, 0.4% of xanthan gum, 1.5% of essence, 0.5% of berberine, 0.15% of sucralose, 0.3% of sodium benzoate and the balance of water.
Example 2
The product form of the tooth whitening oral care composition is toothpaste, and the mass percentages of the raw material components are as follows:
20% of hydrated silica, 35% of sorbitol, 5% of glycerol, 4% of sodium lauryl sulfate, 0.4% of sodium carboxymethylcellulose, 0.2% of xanthan gum, 2% of essence, 2% of berberine, 0.3% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 2
An oral care toothpaste comprises the following raw material components in percentage by mass:
20% of hydrated silica, 35% of sorbitol, 5% of glycerol, 4% of sodium lauryl sulfate, 0.4% of sodium carboxymethylcellulose, 0.2% of xanthan gum, 2% of essence, 0.3% of sucralose, 0.3% of sodium benzoate and the balance of water.
Example 3
The product form of the tooth whitening oral care composition is a mouth cleaning liquid, and the tooth whitening oral care composition comprises the following raw material components in percentage by mass:
15 percent of sorbitol, 5 percent of glycerol, 1 percent of sodium lauryl sulfate, 1 percent of essence, 0.1 percent of berberine, 0.1 percent of sucralose, 0.3 percent of sodium benzoate and the balance of water.
Comparative example 3
An oral care mouthwash is prepared from the following raw material components in percentage by mass:
15 percent of sorbitol, 5 percent of glycerol, 0.1 percent of sodium lauryl sulfate, 1 percent of essence, 0.1 percent of berberine, 0.1 percent of sucralose, 0.3 percent of sodium benzoate and the balance of water.
Example 4
The product form of the tooth whitening oral care composition is a mouth rinse, and the product form comprises the following raw material components in percentage by mass:
15 percent of sorbitol, 5 percent of glycerol, 0.4 percent of sodium lauryl sulfate, 1 percent of essence, 0.2 percent of berberine, 0.1 percent of sucralose, 0.3 percent of sodium benzoate and the balance of water.
Comparative example 4
An oral care mouthwash is prepared from the following raw material components in percentage by mass:
15 percent of sorbitol, 5 percent of glycerol, 0.4 percent of sodium lauryl sulfate, 1 percent of essence, 0.1 percent of sucralose, 0.3 percent of sodium benzoate and the balance of water.
Example 5
The product form of the tooth whitening oral care composition is gel, and the mass percentages of the raw material components are as follows:
15% of glycerol, 1% of poloxamer 407 (polyoxyethylene and polyoxypropylene block copolymer), 9401% of carbomer, 1.5% of essence, 0.5% of berberine, 0.15% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 5
An oral care gel comprises the following raw material components in percentage by mass:
15% of glycerin, 4071% of poloxamer, 8978% of carbomer, 8978% of zxft 8978% of essence, 0.5% of berberine, 0.15% of sucralose, 0.3% of sodium benzoate and the balance of water.
Example 6
The product form of the tooth whitening oral care composition is gel, and the mass percentages of the raw material components are as follows:
15% of glycerin, 4071% of poloxamer, 8978% of carbomer, 8978% of zxft 8978% of essence, 0.5% of berberine, 0.05% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 6
An oral care gel comprises the following raw material components in percentage by mass:
15% of glycerin, 4071% of poloxamer, 8978% of carbomer, 8978% of zxft 8978% of essence, 0.05% of sucralose, 0.3% of sodium benzoate and the balance of water.
Example 7
The product form of the tooth whitening oral care composition is a tooth paste, and the product form comprises the following raw material components in percentage by mass:
5% of glycerin, 20% of triethyl citrate, 10% of polyvinyl alcohol, 98010% of carbomer, 40% of hydroxyethyl cellulose, 10% of hydroxypropyl methyl cellulose, 1% of essence, 1% of berberine, 0.2% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 7
An oral care tooth paste comprises the following raw material components in percentage by mass:
5% of glycerol, 20% of triethyl citrate, 10% of polyvinyl alcohol, 40% of hydroxyethyl cellulose, 10% of hydroxypropyl methyl cellulose, 1% of essence, 1% of berberine, 0.2% of sucralose, 0.3% of sodium benzoate and the balance of water.
Example 8
The product form of the tooth whitening oral care composition is a tooth paste, and the product form comprises the following raw material components in percentage by mass:
5% of glycerin, 20% of triethyl citrate, 10% of polyvinyl alcohol, 98010% of carbomer, 40% of hydroxyethyl cellulose, 10% of hydroxypropyl methyl cellulose, 1% of essence, 2% of berberine, 0.2% of sucralose, 0.3% of sodium benzoate and the balance of water.
Comparative example 8
An oral care tooth paste comprises the following raw material components in percentage by mass:
5% of glycerin, 20% of triethyl citrate, 10% of polyvinyl alcohol, 98010% of carbomer, 40% of hydroxyethyl cellulose, 10% of hydroxypropyl methyl cellulose, 1% of essence, 0.2% of sucralose, 0.3% of sodium benzoate and the balance of water.
The ex vivo tooth was subjected to a staining test for examples 1 to 8 and comparative examples 1 to 8, using the following method:
(1) Soaking the excised teeth in the oral care composition (examples 1 to 6, comparative examples 1 to 6) or soaking the surface of the oral care composition with water, sticking the excised teeth in the excised teeth (examples 7 to 8, comparative examples 7 to 8), and starting timing;
(2) After 60 minutes, the excised teeth were taken out, washed clean, and observed whether the excised teeth were stained.
The results of the staining test on the excised teeth of examples 1 to 8 and comparative examples 1 to 8 are shown in table 1:
TABLE 1
Whitening tests were performed on the dyed bovine bone pieces of examples 1 to 8 and comparative examples 2, 4, 6 and 8, using the following methods:
(1) 1g of the oral care composition (examples 1 to 6 and comparative examples 2, 4 and 6) was dropped on the dyed bovine bone pieces or the oral care composition (examples 7 to 8 and 8) was attached to the dyed bovine bone pieces with surface water using 50mM/cm 2 Irradiating Niu Gupian by white light with radiation intensity, and washing the beef bone slices clean after 20 minutes;
(2) The above procedure was repeated for a cumulative 180 minutes of treatment with the oral care composition.
After the oral care composition of examples 1 to 8 is applied to the dyed bovine bone slices, the whitening degree of the dyed bovine bone slices is higher, the higher the numerical value is, the better the whitening effect is, and the specific experimental results are shown in table 2:
TABLE 2
As can be seen from the data in tables 1 and 2, examples 1 to 8 using the technique of the present invention have a good whitening effect on stained bovine bone fragments, and do not stain teeth. The comparative examples 1, 3, 5 and 7 which are out of the technology of the invention are easy to obviously dye teeth, while the comparative examples 2, 4, 6 and 8 can not play the role of obvious whitening.
The above examples are merely illustrative of several embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
Claims (10)
1. The tooth whitening oral care composition is characterized by comprising 0.01-2% of berberine and an anionic material with the berberine content being 2-10 times, wherein the anionic material is at least one of a polymer and a surfactant, the polymer is a polymer containing at least one group of carboxylate, sulfonate and sulfate, the surfactant is a surfactant containing at least one group of carboxylate, sulfonate and sulfate, and the balance is a base material.
2. The tooth whitening oral care composition of claim 1, wherein the composition is in the form of a product of at least one of a toothpaste, a gel, a mouthwash, a strip.
3. The tooth whitening oral care composition according to claim 1, wherein the product form of the composition is toothpaste and comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 10 to 50 percent of grinding agent, 20 to 60 percent of humectant, 0.5 to 5 percent of surfactant, 0.1 to 3 percent of thickening agent and 0.5 to 2 percent of essence.
4. The tooth whitening oral care composition according to claim 3, wherein the abrasive is selected from at least one of hydrated silica, calcium carbonate, calcium phosphate, calcium hydrogen phosphate, calcium pyrophosphate, aluminum hydroxide, microcrystalline cellulose; the humectant is selected from at least one of sorbitol, glycerol, propylene glycol, ethylene glycol and polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer; the thickening agent is at least one selected from sodium carboxymethylcellulose, xanthan gum, carrageenan, guar gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose.
5. The tooth whitening oral care composition according to claim 1, wherein the product form of the composition is a mouthwash, and the composition comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 5 to 30 percent of humectant, 0.4 to 5 percent of surfactant and 0.2 to 2 percent of essence.
6. The tooth whitening oral care composition of claim 5, wherein the humectant is selected from at least one of sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer.
7. The tooth whitening oral care composition according to claim 1, wherein the product form of the composition is a gel and comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 5 to 50 percent of humectant, 0.1 to 4 percent of surfactant, 0.1 to 5 percent of thickening agent and 0.2 to 2 percent of essence.
8. The tooth whitening oral care composition of claim 7, wherein the humectant is selected from at least one of sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol; the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, cocamidopropyl betaine, alkyl glycoside, polyoxyethylene and polyoxypropylene block copolymer; the thickening agent is at least one selected from sodium carboxymethylcellulose, xanthan gum, carrageenan, guar gum, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose.
9. The tooth whitening oral care composition according to claim 1, wherein the product form of the composition is a tooth paste and comprises the following raw materials in percentage by mass: 0.01 to 2 percent of berberine, 60 to 80 percent of film forming agent and 10 to 30 percent of bonding auxiliary agent.
10. The tooth whitening oral care composition of claim 9, wherein the film forming agent is selected from at least one of carbomer, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, polyvinyl alcohol; the bonding auxiliary agent is at least one selected from glycerol, propylene glycol, ethylene glycol, polyethylene glycol and triethyl citrate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211460640.1A CN115778833A (en) | 2022-11-17 | 2022-11-17 | Tooth whitening oral care composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211460640.1A CN115778833A (en) | 2022-11-17 | 2022-11-17 | Tooth whitening oral care composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115778833A true CN115778833A (en) | 2023-03-14 |
Family
ID=85439652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211460640.1A Pending CN115778833A (en) | 2022-11-17 | 2022-11-17 | Tooth whitening oral care composition |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115778833A (en) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0227108A2 (en) * | 1985-12-27 | 1987-07-01 | Lion Corporation | Oral composition |
JPS62205016A (en) * | 1986-03-05 | 1987-09-09 | Sankin Kogyo Kk | Denture cleaner |
JP2005187329A (en) * | 2003-12-24 | 2005-07-14 | Lion Corp | Composition for oral cavity |
JP2012092042A (en) * | 2010-10-27 | 2012-05-17 | Lion Corp | Dentifrice composition and stability improving method of berberine therein |
CN103040682A (en) * | 2012-12-21 | 2013-04-17 | 苏州黑豆软件科技有限公司 | Sterilizing and pathogenic-fire reducing mouthwash and preparation method thereof |
DE102014223535A1 (en) * | 2014-11-18 | 2015-07-23 | Henkel Ag & Co. Kgaa | Oral and dental care and cleaning products with improved plaque removal |
CN106265327A (en) * | 2016-09-05 | 2017-01-04 | 广州立白企业集团有限公司 | Oral care composition |
CN108606939A (en) * | 2018-03-14 | 2018-10-02 | 弘美制药(中国)有限公司 | A kind of composition and its application and preparation method with oral health function |
CN110755610A (en) * | 2019-09-29 | 2020-02-07 | 天津科技大学 | Antibacterial hydrogel with aggregation-induced emission characteristic and preparation method thereof |
-
2022
- 2022-11-17 CN CN202211460640.1A patent/CN115778833A/en active Pending
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0227108A2 (en) * | 1985-12-27 | 1987-07-01 | Lion Corporation | Oral composition |
JPS62205016A (en) * | 1986-03-05 | 1987-09-09 | Sankin Kogyo Kk | Denture cleaner |
JP2005187329A (en) * | 2003-12-24 | 2005-07-14 | Lion Corp | Composition for oral cavity |
JP2012092042A (en) * | 2010-10-27 | 2012-05-17 | Lion Corp | Dentifrice composition and stability improving method of berberine therein |
CN103040682A (en) * | 2012-12-21 | 2013-04-17 | 苏州黑豆软件科技有限公司 | Sterilizing and pathogenic-fire reducing mouthwash and preparation method thereof |
DE102014223535A1 (en) * | 2014-11-18 | 2015-07-23 | Henkel Ag & Co. Kgaa | Oral and dental care and cleaning products with improved plaque removal |
CN106265327A (en) * | 2016-09-05 | 2017-01-04 | 广州立白企业集团有限公司 | Oral care composition |
CN108606939A (en) * | 2018-03-14 | 2018-10-02 | 弘美制药(中国)有限公司 | A kind of composition and its application and preparation method with oral health function |
CN110755610A (en) * | 2019-09-29 | 2020-02-07 | 天津科技大学 | Antibacterial hydrogel with aggregation-induced emission characteristic and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
MICHELLE M. S. LEE ., ET AL: "A highly efficient and AIE-active theranostic agent from natural herbs", 《MATERIALS CHEMISTRY FRONTIERS》, 31 December 2019 (2019-12-31) * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Alkahtani et al. | A review on dental whitening | |
CA3095054C (en) | Oral care compositions comprising a stannous ion source and an amino acid for promoting gum health | |
RU2394554C2 (en) | Composition for oral cavity care containing non-aggregated nano-particles of zinc | |
TWI576116B (en) | Fluoride-stable zinc containing compositions | |
CA3095048C (en) | Oral care compositions comprising a stannous ion source and a neutral amino acid for promoting gum health | |
RU2018105783A (en) | COMPOSITIONS FOR CARE OF THE ORAL CAVITY AND METHODS OF USE | |
BR112020017904B1 (en) | ORAL HYGIENE COMPOSITIONS TO PROMOTE GUM HEALTH | |
RU2010137333A (en) | ORAL CARE PRODUCT AND METHODS OF USE AND PRODUCTION | |
US20060034780A1 (en) | Dental compositions and methods | |
TW201505659A (en) | Oral care product and methods of use and manufacture thereof | |
CN114948764A (en) | Oral care compositions and methods of use | |
RU2722821C2 (en) | Oral care composition | |
US20200306344A1 (en) | Oral composition and method | |
TW201538177A (en) | Oral care compositions and methods | |
CN109528531A (en) | A kind of composition for tooth whitening and the oral care product comprising the composition | |
AU2016381178B2 (en) | Mucin coated silica for bacterial aggregation | |
CN107007538B (en) | Oral care composition containing marine elements, application of oral care composition and toothpaste containing marine elements | |
CN103800210B (en) | A kind of dentistry containing protease, department of stomatology preparation and preparation method thereof | |
CN115778833A (en) | Tooth whitening oral care composition | |
CN111603407A (en) | Whitening toothpaste containing multiple amino acids | |
RU2527691C1 (en) | Tooth paste containing buffer mixture | |
CN114588057A (en) | Fresh whitening toothpaste and preparation process thereof | |
CN113827505A (en) | Whitening anti-allergy silk peptide toothpaste and preparation method thereof | |
WO2023020818A1 (en) | Oral care composition comprising fenugreek gum | |
CN115300425A (en) | Toothpaste for cleaning oral cavity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |