CN109846786A - A kind of Chinese medicine mouth wash and the preparation method and application thereof - Google Patents
A kind of Chinese medicine mouth wash and the preparation method and application thereof Download PDFInfo
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- CN109846786A CN109846786A CN201910225368.0A CN201910225368A CN109846786A CN 109846786 A CN109846786 A CN 109846786A CN 201910225368 A CN201910225368 A CN 201910225368A CN 109846786 A CN109846786 A CN 109846786A
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- chinese medicine
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Abstract
The invention discloses a kind of Chinese medicine mouth washs and the preparation method and application thereof, the Chinese medicine mouth wash is prepared from the following raw materials in parts by weight: peppermint leaf extract 0.1-0.3%, field pennycress extracting solution 0.2-0.4%, red sage root extract 0.1-0.2%, radix scutellariae extracting solution 0.02-0.05%, vitamin B compound 0.01-0.02%, sweetener 1-3%, preservative 0.1-0.2%, active constituent stabilizer 0.01-0.02%, surplus is ultrapure water；Chinese medicine mouth wash of the present invention can be used for the oral care of postoperative patient, reduces postoperative patient since canker sore leads to the chance of infection, improves the success rate of rehabilitation.Material of the present invention is simple, and preparation method is easy to operate, at low cost, with strong points, and fragrant taste, mouthfeel is slightly sweet, is the useful supplement of oral care product.
Description
(1) technical field
The invention belongs to the preparation technical field of oral health preparation, in particular to a kind of Chinese medicine mouth wash and its preparation
Method.
(2) background technique
In China, oral health is just had historically been a concern.With the development of economy, improvement of living standard, people
The consciousness of oral health is also greatly enhanced.With the promotion and variation of the market demand and consumption idea, oral care product
Pattern gradually upgrades to the products such as toothpaste, dental floss, tooth patch, mouthwash, electric toothbrush via initial toothpaste dominance
Group fights.Currently, saprodontia is one of most common disease in oral cavity, average caries incidence can be that oral cavity is main 50% or so
Common disease and one of the most common disease of the mankind, it is classified as people with cancer and cardiovascular disease by the World Health Organization
The big keypoint control disease of class three.Canker sore, also known as recurrent aphthous ulcer are a kind of more typical diseases of cari oris mucosa.It is treating
When these mouth diseases, using and abusing due to antibiotic causes oral cavity flora unbalance.
Data shows that the bacterial plaque of facing 40%-50% can only be removed by routinely brushing teeth, and removing oral soft tissue is shown
Bacterial plaque is substantially helpless.And mouthwash can go deep into each position in oral cavity, be a kind of control bacterial plaque measure of auxiliary well.U.S.'s food
Product and the mouthwash of drug administration (FDA) certification have two classes: containing essential oil and containing the mouthwash of chlorohexidene, these two types of mouthwashes are all
Can be used for a long time, the latter be used for a long time the shortcomings that be easily cause dental calculus formed, facing coloring and the sense of taste change.And essential oil class is gargled
Though saliva permeability is strong, contain alcohol, to the irritating effect in oral cavity.Currently, the effective component object being usually used in mouthwash
There are also following fours for matter: (1) triclosan also known as Yu Jiechun, triclosan, have wide spectrum, efficiently, it is excellent without any irritation taste etc.
Point, but common can generate drug resistance；(2) metronidazole and Tinidazole are mainly used for infection caused by preventing and treating anaerobic bacteria；
(3) hydrogen peroxide has anti-corrosion, and sterilization, eliminating the unusual smell can cause facing decalcification and black hairy tongue etc. secondary with clean function, prolonged application
Effect；(4) Iodophor, it is a kind of novel containing iodine microbicide, but since the Iodophor after dilution is unstable, which wants matching while using,
It is very inconvenient.It can be seen that the above is all not suitable for use in common oral care because of different disadvantages and using restricted.
Therefore, finding the mouthwash that one kind is effective, safe, alcohol-free, can be used for a long time becomes the new of patient's mouth cavity daily Nursing graduate education
Hot spot.
In China, the applicating history of natural drug is long and toxic side effect is small, and materials are convenient, economical and practical, some also tools
There is bactericidal antiphlogistic effect, thus is widely used in basic research and clinical practice.The utilization of Chinese materia medica preparation in the oral cavity is extensive, largely
It grinds to make internal disorder or usurp and shows that Chinese medicine has good curative effect in the diseases such as treatment periodontosis, canker sore.Has sale of finished goods on the market
Chinese medicine class mouthwash, but the problems such as generally existing color is muddy, mouthfeel is poor or contains alcohol, so that its acceptance is lower, no
It is suitble to the oral care of postoperative patient.Therefore, it is just aobvious particularly important to develop a kind of mouthwash that suitable postoperative patient uses.
(3) summary of the invention
It is an object of the present invention to provide a kind of Chinese medicine mouth washs and preparation method thereof, reduce postoperative patient since canker sore is led
The chance for causing infection, improves the success rate of Rehabilitation.
The technical solution adopted by the present invention is that:
The present invention provides a kind of Chinese medicine mouth wash, and the Chinese medicine mouth wash is prepared from the following raw materials in parts by weight: peppermint
Leaf extract 0.1-0.3%, field pennycress extracting solution 0.2-0.4%, red sage root extract 0.1-0.2%, radix scutellariae extracting solution 0.02-
0.05%, vitamin B compound 0.01-0.02%, sweetener 1-3%, preservative 0.1-0.2%, active constituent stabilizer
0.01-0.02%, surplus are ultrapure water；
The peppermint leaf extract, field pennycress extracting solution, red sage root extract and radix scutellariae extracting solution are dried peppermint leaf, Patrinia scaniosaefolia respectively
Grass, Radix Salviae Miltiorrhizae and the respective Aqueous extracts of radix scutellariae；
The sweetener is the one or more of xylitol, plug honey or Aspartame；The preservative is sorbic acid or benzene
Sodium formate；The active constituent stabilizer is polysorbas20；The vitamin B compound is compound preparation (commercially available), contains vitamin
B1, vitamin B2, vitamin B6, niacinamide, calcium pantothenate.
Further, the preferably described Chinese medicine mouth wash is prepared from the following raw materials in parts by weight: peppermint leaf extract 0.1%,
Field pennycress extracting solution 0.2%, red sage root extract 0.1%, radix scutellariae extracting solution 0.02%, complex microorganism B 0.01%, sweetener
1%, preservative 0.1%, active constituent stabilizer 0.01%, surplus is ultrapure water；The sweetener is xylitol；The anti-corrosion
Agent is sorbic acid；The active constituent stabilizer is polysorbas20.
Further, the preferably described Chinese medicine mouth wash is prepared from the following raw materials in parts by weight: peppermint leaf extract 0.3%,
Field pennycress extracting solution 0.4%, red sage root extract 0.2%, radix scutellariae extracting solution 0.05%, complex microorganism B 0.02%, sweetener
3%, preservative 0.2%, active constituent stabilizer 0.02%, surplus is ultrapure water；The sweetener is Aspartame；It is described anti-
Rotten agent is sodium benzoate；The active constituent stabilizer is polysorbas20.
Further, the peppermint leaf extract, field pennycress extracting solution, red sage root extract and radix scutellariae extracting solution are difference
By dried peppermint leaf, field pennycress, Radix Salviae Miltiorrhizae and radix scutellariae with the water of 3 times of weight in 4 DEG C of immersion 4h, then 1h being boiled respectively, being stood, filtering takes
Filtrate is respective extracting solution.
The present invention also provides a kind of preparation methods of Chinese medicine mouth wash, the specific steps are as follows: by the peppermint of formula ratio
The ultrapure water dilution of formula ratio is added, then in leaf extract, field pennycress extracting solution, red sage root extract and the mixing of radix scutellariae extracting solution
1h is boiled, the sweetener, preservative and vitamin B compound of formula ratio is added, boils 30min；It is eventually adding the work of formula ratio
Property stable components agent, after mixing, overnight stand, filtering, using pasteurization carry out sterilization treatment after, obtain Chinese medicine gargle
Saliva dispenses to obtain finished product.
Application of the Chinese medicine mouth wash of the present invention as Patients Following Bone Marrowtransplantation oral cavity nursing agent.
Compared with prior art, beneficial effect of the present invention is mainly reflected in:
Chinese medicine mouth wash of the present invention can be used for the oral care of postoperative patient, reduce postoperative patient due to canker sore
The chance for leading to infection, improves the success rate of rehabilitation.Material of the present invention is simple, and preparation method is easy to operate, at low cost, specific aim
By force, fragrant taste, mouthfeel is slightly sweet, is the useful supplement of oral care product.
(4) Detailed description of the invention
Colonial morphology figure in Fig. 1 embodiment 3, A are negative control, and B is Chinese medicine mouth wash prepared by embodiment 1, and C is to implement
Chinese medicine mouth wash prepared by example 2.
(5) specific embodiment
The present invention is described further combined with specific embodiments below, but protection scope of the present invention is not limited in
This:
Dried peppermint leaf, field pennycress used in the embodiment of the present invention, Radix Salviae Miltiorrhizae, radix scutellariae are according to 2015 editions acquisition preparations of Chinese Pharmacopoeia.
Embodiment 1 prepares 100g Chinese medicine mouth wash
1, it is formulated
Vitamin B compound is for compound preparation (commercially available), containing vitamin B1, vitamin B2, vitamin B6, niacinamide, general
Sour calcium.
Sweetener is xylitol, and preservative is sorbic acid, and active constituent stabilizer is polysorbas20.
2, a kind of preparation method of Chinese medicine mouth wash, steps are as follows:
(1) it prepares selected each single medicinal material extracting solution: selected Chinese medicine (dried peppermint leaf, field pennycress, Radix Salviae Miltiorrhizae, radix scutellariae) is set respectively
In container, add the water of 3 times of weight, in 4 DEG C of immersion 4h；1h is boiled again, is stood, and filtering takes filtrate to get each single medicinal material
Extracting solution；
(2) Chinese medicine extract that (1) obtains is mixed by formula ratio, the ultrapure water dilution of formula ratio is added, then boils
1h adds the sweetener, preservative and vitamin B compound of formula ratio, boils 30min；Be eventually adding formula ratio activity at
Divide stabilizer, after mixing, overnight stand, filtering dispenses to obtain finished product after carrying out sterilization treatment using pasteurization.
Embodiment 2 prepares 100g Chinese medicine mouth wash
1, it is formulated
Vitamin B compound is compound preparation (commercially available), contains vitamin B1, vitamin B2, vitamin B6, niacinamide, pantothenic acid
Calcium.
Sweetener is Aspartame (C14H18N2O5, Mr=294.30), preservative is sodium benzoate, active constituent stabilizer
For polysorbas20.
2, the preparation method is the same as that of Example 1 for a kind of Chinese medicine mouth wash.
The fungistatic effect measurement of embodiment 3, mouthwash
(1) preparation of agar plate
Respectively by embodiment 1, the mouthwash that embodiment 2 is prepared is added to thawing and cooling according to the ratio of volume ratio 3:7
Into 60 DEG C or so of agar mediums, using the aqua sterilisa of equivalent as negative control under similarity condition.Agar medium composition:
1.0 grams of tryptone, 0.5 gram of yeast extract, 1.0 grams of sodium chloride, 1.5 grams of agar, it is settled to 100mL with deionized water, it is high
Pressure sterilizing 20 minutes, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices becomes agar plate.
(2) inoculated bacteria
By Escherichia coli (ATC8099) at 37 DEG C, cultivate under the conditions of 180rpm to OD600=0.6-0.8 obtains large intestine bar
Bacterium bacterium solution.After the made agar plate total condensation of step (1), 0.05mL Escherichia coli bacteria liquid is taken to be spread evenly across above-mentioned plate
On, 37 DEG C are incubated overnight.
The results show that visible a large amount of bacterium colonies are formed on negative control group culture dish, white (A in Fig. 1), (figure of embodiment 1
B in 1) and two kinds of formula mouth wash group culture dishes of embodiment 2 (C in Fig. 1) on have no that bacterium colony is formed.
The effect of embodiment 4, mouthwash, is studied
Patients Following Bone Marrowtransplantation is almost nil in the hollow phase leucocyte of marrow, easily concurrent severe systemic infection, threat to life.
And canker sore is the main reason for leading to general infection.So it is concurrent that patient oral cavity can be prevented or be mitigated to effective oral care
Disease improves the purpose of bone-marrow transplantation success rate to reach prevention infection.Using Chinese medicine mouth wash of the invention to 60 marrow
Transplant patient carries out oral care experiment, wherein male 36, female 24, max age 47 years old, minimal ages 10 years old.60 are tried
The person of testing is divided into 3 groups, in embodiment 1 and embodiment 22 kinds of formula mouth wash and existing mouthwash (Li Shidelin is purchased from
Wu-Mart) it is tested as control.Experimenter is early, middle and late daily before the meal with specified mouthwash, continues 5 days.It gargles every time
Take oral cavity fluid inspection mouthwash to staphylococcic clearance rate after mouthful.The staphylococcus clearance rate of each experimental group all uses average value
It calculates.As a result such as table 1, the results show that the staphylococcus using the mouthwash of embodiment 1 and the preparation of embodiment 2, in patient oral cavity
Clearance rate is significantly higher than control group, and the incidence of canker sore is significantly lower than control group.
1 mouthwash efficacy study of table
| Group | Bacteria clearance | Canker sore incidence |
| 1 mouthwash of embodiment | 84.2% | 10% |
| 2 mouthwash of embodiment | 91.4% | 10% |
| Control | 47.4% | 40% |
Claims (8)
1. a kind of Chinese medicine mouth wash, it is characterised in that the Chinese medicine mouth wash is prepared from the following raw materials in parts by weight: dried peppermint leaf
Extracting solution 0.1-0.3%, field pennycress extracting solution 0.2-0.4%, red sage root extract 0.1-0.2%, radix scutellariae extracting solution 0.02-
0.05%, vitamin B compound 0.01-0.02%, sweetener 1-3%, preservative 0.1-0.2%, active constituent stabilizer 0.01-
0.02%, surplus is ultrapure water；
The peppermint leaf extract, field pennycress extracting solution, red sage root extract and radix scutellariae extracting solution be respectively dried peppermint leaf, field pennycress,
Radix Salviae Miltiorrhizae and the respective Aqueous extracts of radix scutellariae；
The active constituent stabilizer is polysorbas20.
2. Chinese medicine mouth wash as described in claim 1, it is characterised in that the preservative is sorbic acid or sodium benzoate.
3. Chinese medicine mouth wash as described in claim 1, it is characterised in that the sweetener is xylitol, plug honey or Aspartame
It is one or more of.
4. Chinese medicine mouth wash as described in claim 1, it is characterised in that the peppermint leaf extract, field pennycress extracting solution, Radix Salviae Miltiorrhizae
Extracting solution and radix scutellariae extracting solution be respectively by dried peppermint leaf, field pennycress, Radix Salviae Miltiorrhizae and radix scutellariae with the water of 3 times of weight in 4 DEG C of immersion 4h, then
1h is boiled respectively, is stood, and filtering, taking filtrate is respective extracting solution.
5. Chinese medicine mouth wash as described in claim 1, it is characterised in that the Chinese medicine mouth wash by following weight proportion raw material
Be made: peppermint leaf extract 0.1%, field pennycress extracting solution 0.2%, red sage root extract 0.1%, radix scutellariae extracting solution 0.02% are multiple
Vitamin B 0.01% is closed, sweetener 1%, preservative 0.1%, active constituent stabilizer 0.01%, surplus is ultrapure water；It is described
Sweetener is xylitol；The preservative is sorbic acid；The active constituent stabilizer is polysorbas20.
6. Chinese medicine mouth wash as described in claim 1, it is characterised in that the Chinese medicine mouth wash by following weight proportion raw material
Be made: peppermint leaf extract 0.3%, field pennycress extracting solution 0.4%, red sage root extract 0.2%, radix scutellariae extracting solution 0.05% are multiple
Microorganism B0.02% is closed, sweetener 3%, preservative 0.2%, active constituent stabilizer 0.02%, surplus is ultrapure water；It is described
Sweetener is Aspartame；The preservative is sodium benzoate；The active constituent stabilizer is polysorbas20.
7. a kind of preparation method of Chinese medicine mouth wash described in claim 1, it is characterised in that the method is as follows: by formula ratio
The ultrapure water dilution of formula ratio is added in peppermint leaf extract, field pennycress extracting solution, red sage root extract and the mixing of radix scutellariae extracting solution,
Then 1h is boiled, the sweetener, preservative and vitamin B compound of formula ratio is added, boils 30min；It is eventually adding formula ratio
Active constituent stabilizer, after mixing, overnight stand, filtering, using pasteurization carry out sterilization treatment after, in acquisition
Medicine mouthwash dispenses to obtain finished product.
8. a kind of application of the Chinese medicine mouth wash described in claim 1 as Patients Following Bone Marrowtransplantation oral cavity nursing agent.
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Cited By (1)
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| CN112057387A (en) * | 2020-09-30 | 2020-12-11 | 海南鸿翼医疗器械有限公司 | Gargle for relieving oral wound pain and preparation method thereof |
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