CN109010098A - Antimicrobial mouthwash and preparation method thereof - Google Patents
Antimicrobial mouthwash and preparation method thereof Download PDFInfo
- Publication number
- CN109010098A CN109010098A CN201811237311.4A CN201811237311A CN109010098A CN 109010098 A CN109010098 A CN 109010098A CN 201811237311 A CN201811237311 A CN 201811237311A CN 109010098 A CN109010098 A CN 109010098A
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- regulator
- antimicrobial mouthwash
- formula ratio
- ethyl alcohol
- antimicrobial
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 67
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 64
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 86
- 235000019441 ethanol Nutrition 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000000796 flavoring agent Substances 0.000 claims abstract description 33
- 239000003205 fragrance Substances 0.000 claims abstract description 32
- 235000019634 flavors Nutrition 0.000 claims abstract description 31
- 239000000080 wetting agent Substances 0.000 claims abstract description 29
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 22
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940041616 menthol Drugs 0.000 claims abstract description 22
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 21
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 21
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000811 xylitol Substances 0.000 claims abstract description 21
- 235000010447 xylitol Nutrition 0.000 claims abstract description 21
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 21
- 229960002675 xylitol Drugs 0.000 claims abstract description 21
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 11
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 11
- 239000000049 pigment Substances 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 239000000341 volatile oil Substances 0.000 claims description 13
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 229960003260 chlorhexidine Drugs 0.000 claims description 10
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical group [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims description 9
- 235000013373 food additive Nutrition 0.000 claims description 7
- 239000002778 food additive Substances 0.000 claims description 7
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 235000012208 gluconic acid Nutrition 0.000 claims description 6
- 239000000174 gluconic acid Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 4
- 229920000570 polyether Polymers 0.000 claims description 4
- 241000972155 Moschus Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 239000000203 mixture Substances 0.000 abstract description 6
- 208000030194 mouth disease Diseases 0.000 abstract description 6
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 208000010266 Aggressive Periodontitis Diseases 0.000 abstract description 3
- 201000006727 periodontosis Diseases 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 244000153234 Hibiscus abelmoschus Species 0.000 description 12
- 230000000844 anti-bacterial effect Effects 0.000 description 12
- 241000219095 Vitis Species 0.000 description 9
- 235000009754 Vitis X bourquina Nutrition 0.000 description 9
- 235000012333 Vitis X labruscana Nutrition 0.000 description 9
- 235000014787 Vitis vinifera Nutrition 0.000 description 9
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000003300 oropharynx Anatomy 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- 229960000790 thymol Drugs 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000555682 Forsythia x intermedia Species 0.000 description 1
- 206010018785 Gingival infections Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000003325 Ilex Nutrition 0.000 description 1
- 241000209035 Ilex Species 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention relates to a kind of antimicrobial mouthwashs and preparation method thereof, belong to mouthrinse composition technical field.The antimicrobial mouthwash includes the component of following mass percent: menthol 0.01~0.05%, xylitol 0.5~3.0%, D-sorbite 0.5~2.0%, flavor regulator 0.01~0.08%, chlorhexidine gluconate 0.02~0.2%, ethyl alcohol 0.5~3.0%, fragrance regulator 0.01~0.05%, wetting agent 0.05~2.0%, surplus are water.The antimicrobial mouthwash, can quickly, holding effect kill oral cavity germ, effectively prevent periodontosis and other mouth diseases, and antimicrobial mouthwash formula is rationally, properties of product are stablized, and prepare simple, it is easy to accomplish industrialized production.
Description
Technical field
The invention belongs to mouthrinse composition technical fields, and in particular to a kind of antimicrobial mouthwash and preparation method thereof.
Background technique
Mouthwash is used as oral care product, primarily serves the prevention of dental caries, the formation that prevents dental plaque and calculus dentalis, tooth
Tooth whitening, the effect of breath freshening.Mouthwash mainly includes following component: primary solvent, secondary solvent, surfactant, profit
Humectant, flavoring agent, sweetener etc..Primary solvent is generally water.The optional alcohols of secondary solvent, such as ethyl alcohol, propyl alcohol, polyethylene glycol
Deng.The optional type of surfactant is more, such as poloxamer and polysorbate.There are many flavoring agents, as pepper, peppermint,
Spearmint, Chinese ilex and cortex cinnamomi etc..In addition, the mouthwash with antibacterial effect can add fungicide, such as chlorhexidine gluconate.
Mouthrinse product needs rigorous equilibrium many factors, comprising: chemical stability, compatibility and the biology of active component
Utilization rate, to achieve the effect that treatment and/or beauty；The taste and mouthfeel characteristic of product, in order to consumer's receiving, and
Retain in oral cavity more long to provide effect；The negative effect during use is avoided or reduced, such as may originate from anti-microbial cationic
Tooth discoloration caused by component；The physical stability of product, in order to long-time storage.The choosing of the component of above-mentioned factor and mouthwash
It selects, the proportionate relationship between each component and preparation method have substantial connection.
Application publication number is that the patent of invention of CN103893026A discloses a kind of gargling for oral cleaning and health care
Water, the constituent and its weight ratio of the mouthwash are as follows: small active peptides 0.2%~2%, glycerol 5%~15% hydrogenate castor
Sesame oil 0.5%~3%, chlorhexidine gluconate 0.05%~0.5%, xylitol 2.5%~10%, potassium sorbate 0.1%~
0.3%, Sucralose 0.01%~0.03%, menthol 0.025%~0.1%, orange flavor 0.025%~0.1%, ethyl alcohol
1%~15%.The antimicrobial component chlorhexidine gluconate content of mouthwash is lower, and bactericidal effect is poor.Containing small in mouthwash
Molecular activity peptide, and small active peptides are American-cockroach-extract, extracting method is complex, and the ingredient extracted does not have
Specific test, i.e., specific ingredient is unknown, uncertain whether to have the substance being harmful to the human body.
Application publication number be CN103977081B patent of invention disclose it is a kind of inhibit oropharynx position pathogenic bacteria and mention
The composition of high oropharynx immunity, the composition contain the ingredient of following weight percent: Chlorhexidine 0.05%~0.07%, gold
Honeysuckle flower extract 0.1%~0.8%, forsythia suspense extraction 0.1%~0.8%, chitosan oligosaccharide 0.3%~0.7%, glycerol 3%~
6%, taste freshener is appropriate, and appropriate sweetener, purified water adds to 100%.Contain Chinese medical extract in the composition, with anti-inflammatory
It is unobvious to the effect of fresh breath and clean teeth for the purpose of relieving sore-throat.
It can be seen that other auxiliary elements need to be reasonably selected and be reasonably selected to the antimicrobial composition of mouthwash, to reach
To antibacterial, stabilization and the suitable effect of taste.
Summary of the invention
The object of the present invention is to provide a kind of antimicrobial mouthwash, the antimicrobial mouthwash bactericidal effect preferably, clean taste.
It is a further object to provide a kind of preparation methods of antimicrobial mouthwash.
In order to achieve the goal above, the technical scheme adopted by the invention is as follows: antimicrobial mouthwash, including following mass percent
Component: menthol 0.01~0.05%, xylitol 0.5~3.0%, D-sorbite 0.5~2.0%, flavor regulator 0.01
~0.08%, chlorhexidine gluconate 0.02~0.2%, ethyl alcohol 0.5~3.0%, fragrance regulator 0.01~0.05%, wetting
Agent 0.05~2.0%, surplus are water.
Further, the flavor regulator is one of amino acids food additives, sweetener or a variety of.
Further, the sweetener is o-benzoic sulfimide sodium.
Further, the wetting agent is one of poly alkyl alcohol ethylene oxide ether, polyethylene glycol, glycerin polyether or more
Kind.
Further, further include mass percent be 0.01~0.02% edible pigment.
Further, the edible pigment is brilliant blue.
Further, the fragrance regulator is Moschus essential oil.
The preparation method of antimicrobial mouthwash, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Beneficial effects of the present invention:
Antimicrobial mouthwash of the invention, the chlorhexidine gluconate contained has broad-spectrum antibacterial bactericidal effect, to gram
Positive, negative bacterium and fungi have stronger killing effect.Ethyl alcohol can dissolve menthol, fragrance regulator, wetting as solvent
Agent, while ethyl alcohol can also kill the germ in oral cavity, chlorhexidine gluconate and ethyl alcohol cooperate, can quickly, persistently kill
Go out oral cavity germ, and tooth can be reduced by effectively preventing periodontosis and other mouth diseases, use of gargling before and after repairing, plantation, extraction
Gum infection.
Antimicrobial mouthwash of the invention, the menthol contained may make product with peppermint fragrance and have refrigerant work
With so that the breath freshening of user.Because of the irritant smell of chlorhexidine gluconate and ethyl alcohol, it is unfavorable for user and connects
By, therefore add xylose bland flavour regulator.The taste of antimicrobial mouthwash can be adjusted in xylose bland flavour regulator,
Xylitol can increase the sweet taste of antimicrobial mouthwash, and the mouthfeel of antimicrobial mouthwash can be adjusted to user and is subjected to by flavor regulator
State.Fragrance regulator uses Moschus essential oil, contains thymol in Moschus essential oil, thymol is a kind of monoterpene phenol, right
Bacterium, fungi etc. have good antibacterial and bactericidal activity, have the function of antibacterial anti-inflammatory.In addition, Moschus essential oil can be used as
Food additives be used for food Storage, can also and antibiotic synergism to solve the problems, such as bacterial drug resistance.Meanwhile
Moschus essential oil fragrance is pleasant, and the smell of antimicrobial mouthwash can be adjusted to the acceptable state of user.
Antimicrobial mouthwash of the invention, the D-sorbite contained have sweet taste, the taste of antimicrobial mouthwash are adjusted, simultaneously
D-sorbite can be used as chelating agent, stabilizer, improve the chemical stability of antimicrobial mouthwash, gargle conducive to long-time storage antibacterial
Liquid.Wetting agent may make each component dissolution to be uniformly dispersed, so that antimicrobial mouthwash long-time storage is not in precipitating or divides
Layer phenomenon, improves the physical stability and chemical stability of antimicrobial mouthwash.
Antimicrobial mouthwash of the invention, the edible pigment contained both can be by the color adaptation of antimicrobial mouthwash to more
Salubrious feeling, and adverse effect will not be generated to user.
Antimicrobial mouthwash of the invention, formula rationally, stablize by properties of product, prepares simple, it is easy to accomplish industrialized production.
Specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.01%, xylitol 2.0%, D-sorbite 0.8%, flavor regulator 0.01%, gluconic acid chlorine oneself
Fixed 0.02%, ethyl alcohol 3%, fragrance regulator 0.05%, wetting agent 0.08%, edible pigment 0.01%, surplus is water.
Wherein, flavor regulator is amino acids food additives.
Fragrance regulator is Moschus essential oil.
Wetting agent is poly alkyl alcohol ethylene oxide ether.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 2
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.03%, xylitol 3.0%, D-sorbite 0.5%, flavor regulator 0.06%, gluconic acid chlorine oneself
Fixed 0.15%, ethyl alcohol 1%, fragrance regulator 0.03%, wetting agent 0.05%, edible pigment 0.01%, surplus is water.
Wherein, flavor regulator is amino acids food additives.
Fragrance regulator is Moschus essential oil.
Wetting agent is poly alkyl alcohol ethylene oxide ether.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 3
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.05%, xylitol 0.5%, D-sorbite 2%, flavor regulator 0.08%, chlorhexidine gluconate
0.2%, ethyl alcohol 0.5%, fragrance regulator 0.04%, wetting agent 2%, edible pigment 0.02%, surplus are water.
Wherein, flavor regulator is o-benzoic sulfimide sodium.
Fragrance regulator is Moschus essential oil.
Wetting agent is glycerin polyether.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 4
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.02%, xylitol 2.5%, D-sorbite 1.5%, flavor regulator 0.04%, gluconic acid chlorine oneself
Fixed 0.1%, ethyl alcohol 1.5%, fragrance regulator 0.01%, wetting agent 1%, edible pigment 0.1%, surplus is water.
Wherein, flavor regulator is o-benzoic sulfimide sodium.
Fragrance regulator is Moschus essential oil.
Wetting agent is polyethylene glycol.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 5
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.04%, xylitol 1%, D-sorbite 1%, flavor regulator 0.02%, chlorhexidine gluconate
0.06%, ethyl alcohol 1.8%, fragrance regulator 0.03%, wetting agent 1.5%, edible pigment 0.02%, surplus are water.
Wherein, flavor regulator is amino acids food additives.
Fragrance regulator is Moschus essential oil.
Wetting agent is poly alkyl alcohol ethylene oxide ether.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 6
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.05%, xylitol 0.8%, D-sorbite 1.8%, flavor regulator 0.03%, gluconic acid chlorine oneself
Fixed 0.08%, ethyl alcohol 2%, fragrance regulator 0.02%, wetting agent 1.2%, edible pigment 0.02%, surplus is water.
Wherein, flavor regulator is amino acids food additives.
Fragrance regulator is Moschus essential oil.
Wetting agent is polyethylene glycol.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Embodiment 7
The antimicrobial mouthwash of the present embodiment, the component including following mass percent:
Menthol 0.04%, xylitol 2.0%, D-sorbite 1.3%, flavor regulator 0.02%, gluconic acid chlorine oneself
Fixed 0.03%, ethyl alcohol 2.5%, fragrance regulator 0.04%, wetting agent 1.5%, edible pigment 0.01%, surplus is water.
Wherein, flavor regulator is o-benzoic sulfimide sodium.
Fragrance regulator is Moschus essential oil.
Wetting agent is glycerin polyether.
Edible pigment is brilliant blue.
The preparation method of the antimicrobial mouthwash of the present embodiment, comprising the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the grape of formula ratio is added
Saccharic acid Chlorhexidine and edible pigment.
Test example
The bactericidal effect of antimicrobial mouthwash in embodiment 1-7 is tested, the strain of selection is Staphylococcus aureus
Bacterium, Escherichia coli and Candida albicans.
The preparation of bacteria suspension: using sterile distilled water 5mL, and the staphylococcus aureus cultivated for 24 hours, Escherichia coli, 48h are trained
Feeding Candida albicans is diluted to bacteria suspension with the phosphate buffer of 0.03mol/L respectively.
Bacteria suspension quantitative disinfecting test: the antimicrobial mouthwash in 5.0mL embodiment 1-7 is taken in sterile test tube respectively, then
The antimicrobial mouthwash for taking 100 μ L of bacteria suspension to be added into 5.0mL embodiment 1-7 respectively, which is vortexed, to be mixed.Effect divides to the 1min time
It does not take 1mL bacterium medicine mixed liquor to be added into the sterile test tube of the neutralizer containing 5mL to mix.The liquid or dilute is taken after neutralization 10min
Liquid 1.0mL inoculation sterilized petri dishes are released, ordinary nutrient agar culture medium is poured into, are inverted culture (golden yellow grape for 24 hours in 37 DEG C of incubators
Coccus, Escherichia coli), 48h (Candida albicans) counts flat-plate bacterial colony number, and empirical average three times, is averaged, and calculates sterilization
Rate.Test result is as shown in table 1.
The bactericidal effect of 1 antimicrobial mouthwash of table
Seen from table 1, antimicrobial mouthwash of the invention, interior Escherichia coli, staphylococcus aureus, the white killed of 30s are read
Pearl bacterium.Sterilizing rate is higher, can quick, holding effect killing oral cavity germ.
Function and effect detection to mouth disease
The patient with mouth disease to antimicrobial mouthwash of the invention not allergy is randomly selected, embodiment 1-7 is used
In antimicrobial mouthwash gargle, 10mL is used every time, containing gargling 1-3min, continuous observation Oral symptoms, as a result such as 2 institute of table
Show.
Function and effect of 2 antimicrobial mouthwash of table to mouth disease
As can be seen from Table 2, antimicrobial mouthwash of the invention, can effectively prevent periodontosis and other mouth diseases.
Claims (8)
1. antimicrobial mouthwash, which is characterized in that the component including following mass percent:
Menthol 0.01~0.05%；
Xylitol 0.5~3.0%；
D-sorbite 0.5~2.0%；
Flavor regulator 0.01~0.08%；
Chlorhexidine gluconate 0.02~0.2%；
Ethyl alcohol 0.5~3.0%；
Fragrance regulator 0.01~0.05%；
Wetting agent 0.05~2.0%；
Surplus is water.
2. antimicrobial mouthwash according to claim 1, which is characterized in that the flavor regulator is amino acids food additive
Add one of agent, sweetener or a variety of.
3. antimicrobial mouthwash according to claim 2, which is characterized in that the sweetener is o-benzoic sulfimide
Sodium.
4. antimicrobial mouthwash according to claim 1, which is characterized in that the wetting agent is poly alkyl alcohol ethylene oxide
One of ether, polyethylene glycol, glycerin polyether are a variety of.
5. antimicrobial mouthwash according to claim 1, which is characterized in that further include mass percent be 0.01~0.02%
Edible pigment.
6. antimicrobial mouthwash according to claim 5, which is characterized in that the edible pigment is brilliant blue.
7. antimicrobial mouthwash according to claim 1, which is characterized in that the fragrance regulator is Moschus essential oil.
8. the preparation method of antimicrobial mouthwash, which comprises the following steps:
1) menthol, the fragrance regulator, wetting agent for taking formula ratio, are dissolved in the ethyl alcohol of formula ratio, obtain ethyl alcohol dissolved matter；
2) xylitol, D-sorbite, flavor regulator for taking formula ratio, are dissolved in the water of formula ratio, obtain water dissolved matter；
3) ethyl alcohol dissolved matter in step 1) is uniformly mixed with the water dissolved matter in step 2), and the gluconic acid of formula ratio is added
Chlorhexidine and edible pigment.
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| CN201811237311.4A CN109010098A (en) | 2018-10-23 | 2018-10-23 | Antimicrobial mouthwash and preparation method thereof |
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| CN201811237311.4A CN109010098A (en) | 2018-10-23 | 2018-10-23 | Antimicrobial mouthwash and preparation method thereof |
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| CN111658626A (en) * | 2019-03-06 | 2020-09-15 | 成都一平医药科技发展有限公司 | Pharmaceutical composition, preparation method and medical application thereof |
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