CN110314110A - A kind of effervescent tablet type mouthwash and preparation method thereof - Google Patents
A kind of effervescent tablet type mouthwash and preparation method thereof Download PDFInfo
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- CN110314110A CN110314110A CN201910480595.8A CN201910480595A CN110314110A CN 110314110 A CN110314110 A CN 110314110A CN 201910480595 A CN201910480595 A CN 201910480595A CN 110314110 A CN110314110 A CN 110314110A
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- effervescent tablet
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- mouthwash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Abstract
The invention discloses a kind of effervescent tablet type mouthwashes and preparation method thereof.The effervescent tablet type mouthwash contains tartaric acid 18-30%, sodium carbonate 15-35%, sodium carboxymethylcellulose 10-15%, citric acid 10-25%, chlorhexidine gluconate 1-5%, xylitol 4-7%, D-sorbite 1-3%, menthol 0.01-0.05%.Component sugar glucose acid Chlorhexidine of the invention is not absorbed by the body, and can directly exclude in vitro, pregnant woman children can be used.Effervescent tablet provided by the present invention gargle water energy inhibit, remove oral bacteria, effectively prevent decaying tooth, while oral cavity foreign odor can be eliminated, improve bleeding gums.In addition, effervescent tablet type mouthwash provided by the present invention is easy to outgoing and carries and uses compared with liquid mouthwash, solves the problems such as inconvenient when the big specification carrying of mouthwash.
Description
Technical field
The present invention relates to technical field of medicine, specifically a kind of effervescent tablet type mouthwash and preparation method thereof.
Background technique
Mouthwash is a kind of common oral-cavity cleaning products, is had many advantages, such as using simple, price is human-oriented, thus mouthwash
It is popular on the market.Mouthwash can solve many oral problems, such as oral peculiar smell, oral mucosa ulcer, periodontitis, tooth
Oulorrhagia, saprodontia etc..Traditional mouthwash contains more alcohol, and alcohol can play disinfection and sterilization to fragile oral environment
Effect, but irritation is too strong, is not appropriate for daily cleaning.Also be not suitable for pregnant woman children and driver containing spirituous mouthwash
Member uses.In addition, the bottled mouthwash of tradition is due to the heavy easy side leakage of volume, in addition cannot carry (such as needs by air, by plane
Delivery etc.), also often there are many inconveniences, for the personage of frequent travel, even more suffers untold misery.
Summary of the invention
The purpose of the present invention is to provide a kind of effervescent tablet type mouthwash and preparation method thereof, which, which has, is killed
Bacterium, disinfection, anti-inflammatory, fresh breath and other effects, and can solve problem inconvenient to carry of going out.
To achieve the purpose of the present invention, the present invention adopts the following technical scheme: a kind of effervescent tablet type mouthwash, feature exist
In the mouthwash is made of by mass percentage following substance: tartaric acid 18-30%, sodium carbonate 15-35%, carboxymethyl cellulose
Plain sodium 10-15%, citric acid 10-25%, chlorhexidine gluconate 1-5%, xylitol 4-7%, D-sorbite 1-3%, peppermint
Brain 0.01-0.05%.
Preferably, the effervescent tablet type mouthwash, including following component and its weight fraction: tartaric acid 25-30%, carbonic acid
Sodium 20-32%, sodium carboxymethylcellulose 10-15%, citric acid 15-20%, chlorhexidine gluconate 2-4%, xylitol 5-
7%, D-sorbite 1-3%, menthol 0.01-0.04%.
Preferably, the effervescent tablet type mouthwash, including following component and its weight fraction: tartaric acid 26%, sodium carbonate
32%, sodium carboxymethylcellulose 11%, citric acid 20%, chlorhexidine gluconate 2.96%, xylitol 6%, D-sorbite
2%, menthol 0.04%.
A kind of preparation method of effervescent tablet type mouthwash, comprising the following steps:
(1) it stocks up: weighing tartaric acid, citric acid, sodium carbonate, sodium carboxymethylcellulose, D-sorbite, the xylose of formula ratio
Pure and mild menthol is crushed and is sieved；
(2) mixing: by tartaric acid, citric acid, chlorhexidine gluconate, D-sorbite, xylitol and menthol according to place
Side's amount configuration, is uniformly mixed, obtains acid mixing A；Sodium carbonate and sodium carboxymethylcellulose are configured according to recipe quantity, mixing is equal
It is even, obtain alkaline mixed material B；
(3) it pelletizes: using water as wetting agent, being pelletized, must be made respectively to acid mixing A and alkaline mixed material B with granulator
Grain A and granulation B, and carry out sieving processing；
(4) it dries: granulation A and granulation B being laid on baking pan, dried under the conditions of 60-70 DEG C；
(5) whole grain whole grain: is carried out to the particle after drying with pelletizing machine；
(6) it mixes: whole grain is mixed；
(7) tabletting: molding film-making is carried out to prepared material, effervesce sheet hardness is made to reach 10kg/cm2More than.
Mouthwash of the invention with effervesce sheet mode presence, need using when need to only take out it is a piece of into the water, effervescent tablet
It will be disintegrated in 60s soluble in water, gargle 30s whenever and wherever possible, solves oral problem.This product not spirituosity, can be applicable in
Any crowd's (including pregnant woman children and driver), mild fanout free region.Contain chlorhexidine gluconate ingredient sterilization safety,
Mucous membrane of mouth and gum will not be stimulated, will not be absorbed by the body, is directly excluded in vitro, to no damage to human body, pregnant woman children
It uses.This product can effectively clean tooth, purify oral cavity, remove mycoderm, tartar, the oral problems such as pre- anti-caries, periodontitis.With bottle
Dress mouthwash is compared, and this product is outgoing to be carried and used conveniently.Particularly with go on business, travel, outdoor sports or office worker in the daytime
For gargling, the use of effervescent tablet mouthwash becomes oral care more efficiently.
Detailed description of the invention
Fig. 1 is the process flow chart of preparation method of the present invention.
It * is critical process control point.
Specific implementation method
One, the main supplementary material drug brief introduction of the present invention
1. gluconic acid chlorhexidine
[character] this product is colourless transparent liquid
[function and effect] Cidex-7.Prevention and treatment for mouth disease.
2. D-sorbite
[character] this product is white crystalline powder；It is odorless, it is sweet；Have draw it is moist.This product is readily soluble in water, in ethanol
Slightly soluble, it is insoluble in chloroform or ether.
[effect] sweetener, slow releasing function.
3. xylitol
[character] this product be white crystals or crystalline powder, it is odorless；Have draw it is moist.This product easily dissolves in water,
It is slightly molten in ethyl alcohol.
[effect] nutritional drugs, sweetener.
4. tartaric acid
[character] this product is white to off-white color particle or crystalline powder.This product is readily soluble in water, in ethanol slightly soluble.
[function and effect] pharmaceutic adjuvant, pH adjusting agent and effervescent agent etc..
5. sodium carbonate
[character] this product is white crystalline powder；Odorless, taste is salty；It is slowly decomposed in humid air；Aqueous solution is put
It sets slightly long, or shaking, or heating, alkalinity enhances.This product dissolves in water, insoluble in ethanol.
[function and effect] pharmaceutic adjuvant, alkalization foaming agent etc..
6. sodium carboxymethylcellulose
[character] this product is white to yellowish threadiness or particulate powder；It is odorless；Have draw it is moist.This product is molten in water
It is expanded into colloidal solution, it is insoluble in ethyl alcohol, ether or chloroform.
[effect] pharmaceutic adjuvant, disintegrating agent and filler, adhesive.
7. menthol
[character] this product is colourless needles or prism-shaped crystallization or white crystalline powder；There are the special aroma of peppermint, taste
It is just pungent, rear refrigerant.This product easily dissolves in ethyl alcohol, chloroform, ether, in water soluble,very slightly.
[effect] pharmaceutic adjuvant, corrigent and aromatic, freshener etc..
Two, preparation step embodiment 1 of the present invention
1. a kind of effervescent tablet type mouthwash, including following component and its weight fraction: tartaric acid 26%, sodium carbonate 32%,
Sodium carboxymethylcellulose 11%, citric acid 20%, chlorhexidine gluconate 2.96%, xylitol 6%, D-sorbite 2%, peppermint
Brain 0.04%.
2. the preparation method of above-mentioned effervescent tablet type mouthwash, comprising the following steps:
(1) it stocks up: weighing the tartaric acid of formula ratio, citric acid, sodium carboxymethylcellulose, D-sorbite, xylitol and thin
Lotus brain crushes and crosses 80 meshes；Sodium carbonate crushes and crosses 30 meshes；
(2) mixing: by tartaric acid, citric acid, chlorhexidine gluconate, D-sorbite, xylitol and menthol according to place
Side's amount configuration, obtains acid mixing A；Sodium carbonate and sodium carboxymethylcellulose are configured according to recipe quantity, obtain alkaline mixed material B；It is acid
Mixing A and alkaline mixed material B stir 10min under 28 turns/min speed respectively, are uniformly mixed；
(3) it pelletizes: using water as wetting agent, being pelletized, must be made respectively to acid mixing A and alkaline mixed material B with granulator
Grain A and granulation B；
(4) dry: granulation A and granulation B being laid on baking pan respectively, 5h is dried under the conditions of 60-70 DEG C, is then cooled down
Processing；
(5) whole grain: whole grain is carried out to the granulation A after drying and the B that pelletizes with pelletizing machine, and crosses the processing of 12 meshes；
(6) it mixes: whole grain is mixed；
(7) tabletting: workshop temperature 18-25 DEG C, humidity be lower than relative humidity 40% under the conditions of, to prepared whole grain into
Row molding film-making, tablet press machine rotation speed is 24 turns/min, and pressure 250KN makes effervesce sheet hardness reach 10kg/cm2With
On.
Embodiment 2
1. a kind of effervescent tablet type mouthwash, including following component and its weight fraction: tartaric acid 20%, sodium carbonate 28%,
Sodium carboxymethylcellulose 15%, citric acid 25%, chlorhexidine gluconate 2.96%, xylitol 6%, D-sorbite 3%, peppermint
Brain 0.04%.
2. the preparation method of above-mentioned effervescent tablet type mouthwash, comprising the following steps:
(1) it stocks up: weighing the tartaric acid of formula ratio, citric acid, sodium carboxymethylcellulose, D-sorbite, xylitol and thin
Lotus brain crushes and crosses 80 meshes；Sodium carbonate crushes and crosses 30 meshes；
(2) mixing: by tartaric acid, citric acid, chlorhexidine gluconate, D-sorbite, xylitol and menthol according to place
Side's amount configuration, obtains acid mixing A；Sodium carbonate and sodium carboxymethylcellulose are configured according to recipe quantity, obtain alkaline mixed material B；It is acid
Mixing A and alkaline mixed material B stir 10min under 28 turns/min speed respectively, are uniformly mixed；
(3) it pelletizes: using water as wetting agent, being pelletized, must be made respectively to acid mixing A and alkaline mixed material B with granulator
Grain A and granulation B；
(4) dry: granulation A and granulation B being laid on baking pan respectively, 5h is dried under the conditions of 60-70 DEG C, is then cooled down
Processing；
(5) whole grain: whole grain is carried out to the granulation A after drying and the B that pelletizes with pelletizing machine, and crosses the processing of 12 meshes；
(6) it mixes: whole grain is mixed；
(7) tabletting: workshop temperature 18-25 DEG C, humidity be lower than relative humidity 40% under the conditions of, to prepared whole grain into
Row molding film-making, tablet press machine rotation speed is 24 turns/min, and pressure 250KN makes effervesce sheet hardness reach 10kg/cm2With
On.
Embodiment 3
1. a kind of effervescent tablet type mouthwash, including following component and its weight fraction: tartaric acid 30%, sodium carbonate 30%,
Sodium carboxymethylcellulose 12%, citric acid 16%, chlorhexidine gluconate 3.96%, xylitol 5%, D-sorbite 3%, peppermint
Brain 0.04%.
2. the preparation method of above-mentioned effervescent tablet type mouthwash, comprising the following steps:
(1) it stocks up: weighing the tartaric acid of formula ratio, citric acid, sodium carboxymethylcellulose, D-sorbite, xylitol and thin
Lotus brain crushes and crosses 80 meshes；Sodium carbonate crushes and crosses 30 meshes；
(2) mixing: by tartaric acid, citric acid, chlorhexidine gluconate, D-sorbite, xylitol and menthol according to place
Side's amount configuration, obtains acid mixing A；Sodium carbonate and sodium carboxymethylcellulose are configured according to recipe quantity, obtain alkaline mixed material B；It is acid
Mixing A and alkaline mixed material B stir 10min under 28 turns/min speed respectively, are uniformly mixed；
(3) it pelletizes: using water as wetting agent, being pelletized, must be made respectively to acid mixing A and alkaline mixed material B with granulator
Grain A and granulation B；
(4) dry: granulation A and granulation B being laid on baking pan respectively, 5h is dried under the conditions of 60-70 DEG C, is then cooled down
Processing；
(5) whole grain: whole grain is carried out to the granulation A after drying and the B that pelletizes with pelletizing machine, and crosses the processing of 12 meshes；
(6) it mixes: whole grain is mixed；
(7) tabletting: workshop temperature 18-25 DEG C, humidity be lower than relative humidity 40% under the conditions of, to prepared whole grain into
Row molding film-making, tablet press machine rotation speed is 24 turns/min, and pressure 250KN makes effervesce sheet hardness reach 10kg/cm2With
On.
Three, [effect] this product of the invention is for improving oral peculiar smell, fresh breath, inhibition bacterium, solving bleeding gums, pre-
Anti-caries etc..
[application method] external application, takes this product a piece of, is put into water, wait be disintegrated completely, gargle can (water temperature be 30-40 DEG C most
It is good)
Four, clinical observation of the present invention
Research object:
50 males and 50 women are selected to carry out clinical observation to a kind of effervescent tablet type mouthwash of the invention.Age is
20-50 years old, 1-3 times each, 30 days are a cycle.
1. application method uses product of the present invention 1-3 times, mucous membrane of mouth and oral malicious experimental observation are carried out.
Effective evaluation standard:
1.1 improve halitosis
1.1 mucous membrane of mouth are non-stimulated
1.3 direct oral cavities are non-toxic.
2. inhibiting bacterium and bleeding gums:
Significant effect 30, hence it is evident that improve 28, invalid 2, all cases have no adverse reaction.
Significant effect of the present invention, to staphylococcus aureus, Candida albicans, Escherichia coli bacteriostasis rate 60% with
On.
Typical clinical case:
Zhao, female, 30 years old, people from Gansu.There are bleeding gums in pregnancy period, and has oral peculiar smell；When brushing teeth sooner or later daily, can all it flow
Blood, after inventive formulation product 3 days, bleeding gums and oral peculiar smell restore normal, and follow-up after half a year is not recurred.
It is high certain, male, 28 years old, Cantonese.Because operating pressure is larger, diet is irregular, malnutritive, saliva of buccal cavity is adhered,
Bleeding gums, oral peculiar smell are heavier, and after product of the present invention 5 days, saliva of buccal cavity is adhered, bleeding gums, oral peculiar smell restore
Normally, follow-up after half a year, does not recur.
The above content is specific preferred embodiment further description to made by the present invention is combined, cannot recognize
Fixed specific implementation of the invention is only limitted to these explanations.For those skilled in the art, do not taking off
Under the premise of from present inventive concept, several simple deduction or replace can also be made, all should be considered as and belong to protection of the invention
Range.
Claims (10)
1. a kind of effervescent tablet type mouthwash, which is characterized in that the mouthwash is made of by mass percentage following substance: tartaric acid
18-30%, sodium carbonate 15-35%, sodium carboxymethylcellulose 10-15%, citric acid 10-25%, chlorhexidine gluconate 1-
5%, xylitol 4-7%, D-sorbite 1-3%, menthol 0.01-0.05%.
2. a kind of effervescent tablet type mouthwash according to claim 1, which is characterized in that the mouthwash presses matter by following substance
Measure percentage composition: tartaric acid 25-30%, sodium carbonate 20-32%, sodium carboxymethylcellulose 10-15%, citric acid 15-20%,
Chlorhexidine gluconate 2-4%, xylitol 5-7%, D-sorbite 1-3%, menthol 0.01-0.04%.
3. a kind of effervescent tablet type mouthwash according to claim 1, which is characterized in that the mouthwash presses matter by following substance
Measure percentage composition: tartaric acid 26%, sodium carbonate 32%, sodium carboxymethylcellulose 11%, citric acid 20%, gluconic acid chlorine oneself
Fixed 2.96%, xylitol 6%, D-sorbite 2%, menthol 0.04%.
4. a kind of effervescent tablet type mouthwash according to claim 1, which is characterized in that including following preparation step:
(1) stock up: weigh the tartaric acid of formula ratio, citric acid, sodium carbonate, sodium carboxymethylcellulose, D-sorbite, xylitol and
Menthol is crushed and is sieved；
(2) mixing: by tartaric acid, citric acid, chlorhexidine gluconate, D-sorbite, xylitol and menthol according to recipe quantity
Configuration is uniformly mixed, obtains acid mixing A；Sodium carbonate and sodium carboxymethylcellulose are configured according to recipe quantity, is uniformly mixed, obtains
Alkaline mixed material B；
(3) pelletize: using water as wetting agent, being pelletized respectively with granulator to acid mixing A and alkaline mixed material B, must pelletize A with
Pelletize B, and carries out sieving processing；
(4) it dries: granulation A and granulation B being laid on baking pan, dried under the conditions of 60-70 DEG C；
(5) whole grain whole grain: is carried out to the particle after drying with pelletizing machine；
(6) it mixes: whole grain is mixed；
(7) tabletting: molding film-making is carried out to prepared material, effervesce sheet hardness is made to reach 10kg/cm2More than.
5. a kind of effervescent tablet type mouthwash according to claim 4, it is characterised in that: step (1) mesotartaric acid, lemon
Acid, sodium carboxymethylcellulose, D-sorbite, xylitol and menthol smash it through 80 meshes, and sodium carbonate smashes it through 30 meshes.
6. a kind of effervescent tablet type mouthwash according to claim 4, it is characterised in that: mixing is divided into acidity in step (2)
Mixing A and alkaline mixed material B.
7. a kind of effervescent tablet type mouthwash according to claim 4, it is characterised in that: stir speed in step (2) when mixing
Degree is 28 turns/min, incorporation time 10min.
8. a kind of effervescent tablet type mouthwash according to claim 4, it is characterised in that: granulation and step (5) in step (3)
Middle whole grain crosses 12 meshes.
9. a kind of effervescent tablet type mouthwash according to claim 4, it is characterised in that: rotary when tabletting in step (7)
Tablet press machine rotation speed is that 18-26 turns/min, pressure 200-300KN.
10. a kind of effervescent tablet type mouthwash according to claim 1, which is characterized in that need to only take out a piece of bubble when use
Rise piece into the water, effervescent tablet is disintegrated soluble in water in 60s, can gargle whenever and wherever possible.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859757A (en) * | 2019-11-22 | 2020-03-06 | 广州康云生物科技有限公司 | Lysozyme-containing mouthwash effervescent tablet and preparation method thereof |
| CN113230173A (en) * | 2021-05-24 | 2021-08-10 | 深圳市西马龙科技有限公司 | Portable effervescent mouthwash |
| WO2022108546A1 (en) * | 2020-11-23 | 2022-05-27 | Hacettepe Üni̇versi̇tesi̇ | Development of dental cleaning formulation in the form of effervescent tablet |
| CN115463049A (en) * | 2022-08-29 | 2022-12-13 | 江苏知原药业股份有限公司 | Gargle formula, production process and production equipment thereof |
| CN115518011A (en) * | 2022-09-30 | 2022-12-27 | 杭州小氟牙防医疗器械有限公司 | Method and equipment for producing sterilizing tooth-protecting mouth wash |
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| CN110859757A (en) * | 2019-11-22 | 2020-03-06 | 广州康云生物科技有限公司 | Lysozyme-containing mouthwash effervescent tablet and preparation method thereof |
| WO2022108546A1 (en) * | 2020-11-23 | 2022-05-27 | Hacettepe Üni̇versi̇tesi̇ | Development of dental cleaning formulation in the form of effervescent tablet |
| CN113230173A (en) * | 2021-05-24 | 2021-08-10 | 深圳市西马龙科技有限公司 | Portable effervescent mouthwash |
| CN115463049A (en) * | 2022-08-29 | 2022-12-13 | 江苏知原药业股份有限公司 | Gargle formula, production process and production equipment thereof |
| CN115463049B (en) * | 2022-08-29 | 2023-10-20 | 江苏知原药业股份有限公司 | Gargle formula and production process and production equipment thereof |
| CN115518011A (en) * | 2022-09-30 | 2022-12-27 | 杭州小氟牙防医疗器械有限公司 | Method and equipment for producing sterilizing tooth-protecting mouth wash |
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