CN101606982A - The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant - Google Patents
The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant Download PDFInfo
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- CN101606982A CN101606982A CNA2008101109504A CN200810110950A CN101606982A CN 101606982 A CN101606982 A CN 101606982A CN A2008101109504 A CNA2008101109504 A CN A2008101109504A CN 200810110950 A CN200810110950 A CN 200810110950A CN 101606982 A CN101606982 A CN 101606982A
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Abstract
The invention discloses the application process of lotus (lotus) plant (comprising Folium Nelumbinis, stem of Rhizoma Nelumbinis, root of Rhizoma Nelumbinis and lotus receptacle) antimicrobial and antiphlogistic activity ingredients for preventing and treating oral disease, this method be the extract with lotus (lotus) plant antimicrobial and antiphlogistic activity be prepared into have oral cavity health, the medicine of therapeutical effect, food and article of everyday use, make it that content of 0.1-25% be arranged in the said goods.Medicine with dental care effect of the present invention can adopt any type of preparation, comprises tablet, spray, powder, membrane, varnish, ointment, gel, gargarism etc.; Food and article of everyday use with oral cavity health protection effect comprise chewing gum, beverage, tea, wine, toothpaste, dentifrice etc.The oral disease that strong antimicrobial that extracts in lotus (lotus) plant and antiphlogistic activity composition are applied to the people, medicine, health food and the article of everyday use of oral disease such as developed and prevented and treated dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis, pharyngitis, had sore throat, the present invention has covered in lotus (lotus) plant antimicrobial and antiphlogistic activity composition in the application of aspects such as new Drug therapy, functional food, article of everyday use and food additive.The present invention has a extensive future, and has important social benefit and economic benefit.
Description
Technical field
The present invention relates to the application of natural materials bioactive ingredients, in particular to the antimicrobial and the application process of antiphlogistic activity composition in preventing and treating oral disease that from various lotuses (lotus) plant (comprising Folium Nelumbinis, stem of Rhizoma Nelumbinis, root of Rhizoma Nelumbinis and lotus receptacle), extract.
Background technology
Lotus (lotus) (Nelumbo nucifer, Nelumbo lutea), section belongs to: Nymphaeceae, Nelumbo.Perennial water plant, herbaceous plant.The leaf circle exceeds the water surface, and long stem of Rhizoma Nelumbinis is arranged, and the tool thorn becomes peltate and gives birth to.The loose more piece of rhizome (Rhizoma Nelumbinis) is grown wild in water-bed mud.Leaf peltate circle, surperficial bottle green, by waxiness white lead back side celadon, full edge also is wavy.Hua Dan is born on bennet top, the high holder water surface.Nut is oval or avette, is commonly called as Semen Nelumbinis, long 1.5～2.5 centimetres.Lotus (lotus) whole body is precious, and Rhizoma Nelumbinis, leaf, stem of Rhizoma Nelumbinis, lotus stamen, Receptaculum Nelumbinis (holder) are used as medicine, can clearing away heat to stop bleeding.Lotus (lotus) is mainly cultivated in Guangxi of China the north, in the Hunan, all there is distribution in Hubei, Jiangxi, Fujian and other many areas, plantation, the applicating history in existing more than 300 year.
Usually pluck Semen Nelumbinis in late summer, its rhizome (Rhizoma Nelumbinis) is edible, also can be used as medicine.Meanwhile, Folium Nelumbinis and stem of Rhizoma Nelumbinis are dropped.People are to the almost few of research of non-fruit part of Semen Nelumbinis plant at present, its leaf and stem also never are used, for the biological activity of the non-fruit of its Semen Nelumbinis plant part and utilize people to know little about it, any activated extract not almost from wherein obtaining.
Summary of the invention
The object of the present invention is to provide and a kind ofly (comprise Folium Nelumbinis, stem of Rhizoma Nelumbinis, root of Rhizoma Nelumbinis and lotus receptacle from lotus (lotus) plant, following omiting) bioactive ingredients that extracts in is being prevented and treated the application process of oral disease, its antimicrobial and antiphlogistic activity effect are fully used, be the mankind's health service.
The inventor finds and successfully extracts, isolates the very strong antimicrobial and the active component of antiphlogistic activity first by research from lotus (lotus) plant.These active component especially have very strong inhibitory action to oral microorganism, such as Streptococcus mutans Streptococcus mutans, porphyromonas gingivalis Porphyromonas gingivalis, candida albicans Candida albican etc.
But, also do not utilize the research report of antimicrobial and antiinflammatory bioactive ingredients in above-mentioned lotus (lotus) plant at present.For this discovery is brought benefit to the mankind better, the invention provides a kind of bioactive ingredients that utilizes in lotus (lotus) plant and prevent and treat the application process of oral disease.The lotus that the inventor provides (lotus) plant antimicrobial and antiphlogistic activity composition are used to prevent and treat the method for oral disease, be lotus (lotus) plant extract is prepared into have oral cavity health, the series of products of therapeutical effect, make it that content of 0.1-25% be arranged in the said goods, in final products weight, concrete content is decided according to the kind of made article.
Above-mentioned oral disease comprises dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis, pharyngitis, has sore throat etc.Because the bioactive ingredients in lotus (lotus) plant has the very strong anti-oral microorganism and the effect of antiinflammatory, the inventor uses it for prevention and treats above-mentioned oral disease and obtained good curative effect.
Above-mentioned lotus (lotus) plant extract is meant the summation that comprises the bioactive ingredients that extracts each positions such as Folium Nelumbinis, stem of Rhizoma Nelumbinis, root of Rhizoma Nelumbinis and lotus receptacle from whole plant of lotus (lotus), also can be the bioactive ingredients that extracts from single position.
The above-mentioned series of products that are used for oral cavity health, therapeutical effect comprise medicine, food and article of everyday use.Comprise lotus (lotus) plant extract, additive in the prescription of these products and be used for the appropriate carrier of this product form, and be prepared from according to the conventional production method of these products.
Above-mentioned medicine with dental care effect, can adopt any type of preparation, comprise tablet, spray, powder, membrane, varnish, ointment, gel, gargarism etc., tablet wherein mainly refers to be suitable for any type of tablet of oral cavity medicine, comprises buccal tablet, bioadhesive paster, dispersible tablet, effervescent tablet, chewable tablet, solution sheet etc.The content of lotus (lotus) plant extract in above-mentioned medicine is at least 1%, in the weight of medicinal mixture, is good with 1-25% generally.
Above-mentioned food with oral cavity health protection effect comprises chewing gum, beverage, tea, wine etc., and the content of lotus (lotus) plant extract in above-mentioned food is at least 0.1%, in the weight of food mix, is good with 0.1-10% generally.
Above-mentioned article of everyday use with oral cavity health protection effect comprises toothpaste, dentifrice, collutory etc., and the content of lotus (lotus) plant extract in above-mentioned article of everyday use is at least 0.1%, in the weight of article of everyday use mixture, is good with 0.1-10% generally.
Lotus provided by the invention (lotus) plant antimicrobial and antiphlogistic activity composition are used to prevent and treat the method for oral disease, strong antimicrobial that will from lotus (lotus) plant leaf, stem, root, extract and the antiphlogistic activity composition oral disease that is applied to the people first, medicine, health food and the article of everyday use of oral disease such as developed and prevented and treated dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis, pharyngitis, had sore throat, have a extensive future, have important social benefit and economic benefit.
The present invention has following outstanding advantage:
1, the medicine of preventing and treating oral disease, health food and the article of everyday use series of products of the present invention's exploitation are raw material with the whole plant of lotus (lotus), positions such as the Folium Nelumbinis that former people are given it up, stem of Rhizoma Nelumbinis are made full use of, saved ample resources, reduced cost significantly, the economic benefit height, market prospect is good.
2, the series of products of the present invention exploitation are compared with traditional product, belong to all-natural product, the active constituent content height, and be mainly used in and prevent and treat oral disease, with strong points, health protection and therapeutic action is more outstanding.
The specific embodiment
The present invention is further specified by the following examples, but embodiment not delimit the scope of the invention.
Embodiment 1
Contain the buccal tablet of Semen Nelumbinis antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 15%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 10%
Mogroside 1%
Mannitol 25%
Dextrin 10%
Mentholum 0.5%
HPMC 4.0％
Magnesium stearate 0.5%
Dehydrated alcohol is an amount of
Preparation method: recipe quantity Fructus Momordicae (or its plant) antimicrobial acivity component extract, lotus (lotus) plant antimicrobial and antiphlogistic activity component extract, mogroside, mannitol, dextrin are fully mixed, sieve, the recipe quantity Mentholum is dissolved in an amount of ethanol, adds in the mixed powder.Make binding agent with 2%HPMC solution, the suitable soft material of system, 16 mesh sieves are granulated, and dry back 14 mesh sieve granulate add magnesium stearate, tabletting behind the mixing.Product efficacy: this buccal tablet anti-inflammation, cooling blood and relieving pain.Can be used for treating oral cavity and throat diseases such as dental caries, periodontitis, gingivitis, oral ulcer, pharyngitis, laryngopharynx swelling and pain.
Embodiment 2
Contain the buccal tablet of Semen Nelumbinis antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 5%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 5%
Mannitol 25%
Dextrin 20%
Mentholum 0.5%
HPMC 4.0％
Magnesium stearate 0.5%
Dehydrated alcohol is an amount of
Preparation method: recipe quantity Fructus Momordicae (or its plant) antimicrobial acivity component extract, lotus (lotus) plant antimicrobial and antiphlogistic activity component extract, mannitol, dextrin are fully mixed, sieve, the recipe quantity Mentholum is dissolved in an amount of ethanol, adds in the mixed powder.Make binding agent with 2%HPMC solution, the suitable soft material of system, 16 mesh sieves are granulated, and dry back 14 mesh sieve granulate add magnesium stearate, tabletting behind the mixing.
Product efficacy: this buccal tablet anti-inflammation, cooling blood and relieving pain.Can be used for treating oral cavity and throat diseases such as dental caries, periodontitis, gingivitis, oral ulcer, pharyngitis, laryngopharynx swelling and pain.
Embodiment 3
Contain the oral spray of lotus (lotus) plant antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 15%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 5%
Ethanol 10%
Glycerol 0.2%
Hibitane 0.05%
Oleum menthae 0.5%
Saccharin sodium 0.03%
Water adds to 100%
Preparation method: hibitane, Oleum menthae are dissolved in the ethanol, add an amount of distilled water.Then Fructus Momordicae (or its plant) extract, lotus (lotus) plant extract, glycerol and saccharin sodium are added in the aqueous solution, stir, add water to full dose, filter, get final product in the spray of packing into the storage medicine bottle.
Product efficacy: this oral spray anti-inflammation, cooling blood and relieving pain.Can be used for treating oral cavity and throat diseases such as dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis, pharyngitis, laryngopharynx swelling and pain.
Embodiment 4
Contain the health-care chewing gum of Semen Nelumbinis antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 5%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 5%
Edible gum base 30%
Mogroside 2%
Mentholum 0.2%
Glycerol 8%
Lecithin 0.6%
Edible essence 0.2%
Preparation method: will eat gum base and be heated to uniform temperature, after fully stirring Fructus Momordicae (or its plant) extract, lotus (lotus) plant extract and all the other adjuvants are added, mix homogeneously is cooled to after the preference temperature with its extruding in flakes, excision forming, packing promptly.
Product efficacy: this health-care chewing gum anti-inflammation, cooling blood and relieving pain.Contact with each position, oral cavity by chewing fully, reach cleaning oral cavity, the effect of the throat's discomfort that takes care of one's teeth, releives.
Embodiment 5
Contain the health-care toothpaste of Semen Nelumbinis antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 5%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 5%
Silicon dioxide 30%
Sorbitol 30%
Glycerol 5%
Sodium carboxymethyl cellulose 1%
Essence 1%
Saccharin sodium 0.1%
Sodium lauryl sulphate 1%
Sodium benzoate 0.1%
Deionized water adds to 100%
Preparation method: earlier sodium carboxymethyl cellulose is dissolved with glycerol and suitable quantity of water, after storing placement, again Fructus Momordicae (or its plant) extract, lotus (lotus) plant extract and all the other each components are added by above-mentioned percentage by weight, stir, vacuum outgas goes out cream promptly.
Product efficacy: this health-care toothpaste anti-inflammation, cooling blood and relieving pain.Not only can take care of one's teeth, cleaning oral cavity, also can be used for preventing and treating oral diseases such as dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis.
Embodiment 6
Contain the health-care chewing gum of Semen Nelumbinis antimicrobial and antiphlogistic activity composition, the percetage by weight of its component is:
Fructus Momordicae (or its plant) antimicrobial acivity composition 5%
Lotus (lotus) plant antimicrobial and antiphlogistic activity composition 5%
Edible gum base 30%
Mogroside 30%
Glucose syrup 20%
Dextrin 6%
Mentholum 0.2%
Glycerol 8%
Lecithin 0.6%
Edible essence 0.2%
Preparation method: will eat gum base and be heated to uniform temperature, after fully stirring Fructus Momordicae (or its plant) extract, lotus (lotus) plant extract and all the other adjuvants are added, mix homogeneously is cooled to after the preference temperature with its extruding in flakes, excision forming, packing promptly.
Product efficacy: this health-care chewing gum anti-inflammation, cooling blood and relieving pain.Contact with each position, oral cavity by chewing fully, reach cleaning oral cavity, the effect of the throat's discomfort that takes care of one's teeth, releives.
Claims (7)
1, lotus (lotus) plant antimicrobial and the application process of antiphlogistic activity composition in preventing and treating oral disease, it is characterized in that lotus (lotus) plant extract is prepared into have oral cavity health, the series of products of therapeutical effect, make it that content of 0.1-25% be arranged in the said goods, in final products weight, concrete content is decided according to the kind of made article.
2, the application process in preventing and treating oral disease according to the described lotus of claim 1 (lotus) plant antimicrobial and antiphlogistic activity composition is characterized in that: described oral disease comprises dental caries, periodontitis, gingivitis, toothache and hemorrhage, oral ulcer, halitosis, pharyngitis, has sore throat etc.
3, the application process in preventing and treating oral disease according to the described lotus of claim 1 (lotus) plant antimicrobial and antiphlogistic activity composition, it is characterized in that: described lotus (lotus) plant extract is meant the summation that comprises the bioactive ingredients that extracts each positions such as Folium Nelumbinis, stem of Rhizoma Nelumbinis, root of Rhizoma Nelumbinis and lotus receptacle from whole plant of lotus (lotus), also can be the bioactive ingredients that extracts from single position.
4, the application process in preventing and treating oral disease according to the described lotus of claim 1 (lotus) plant antimicrobial and antiphlogistic activity composition, it is characterized in that: the described series of products that are used for oral cavity health, therapeutical effect comprise medicine, food and article of everyday use.Comprise lotus (lotus) plant extract, additive in the prescription of these products and be used for the appropriate carrier of this product form, and be prepared from according to the conventional production method of these products.
5, the series of products that are used for oral cavity health, therapeutical effect according to the described lotus of claim 4 (lotus) plant antimicrobial and antiphlogistic activity composition, it is characterized in that: described medicine can adopt any type of preparation, comprise tablet, spray, powder, membrane, varnish, ointment, gel, gargarism etc., tablet wherein mainly refers to be suitable for any type of tablet of oral cavity medicine, comprises buccal tablet, bioadhesive paster, dispersible tablet, effervescent tablet, chewable tablet, solution sheet etc.The content of lotus (lotus) plant extract in above-mentioned medicine is at least 1%, in the weight of medicinal mixture, is good with 1-25% generally.
6, the series of products that are used for oral cavity health, therapeutical effect according to the described lotus of claim 4 (lotus) plant antimicrobial acivity composition, it is characterized in that: described food comprises chewing gum, buccal tablet, beverage, tea, wine etc., the content of lotus (lotus) plant extract in above-mentioned food is at least 0.1%, in the weight of food mix, be good generally with 0.1-10%.
7, the series of products that are used for oral cavity health, therapeutical effect according to the described lotus of claim 4 (lotus) plant antimicrobial acivity composition, it is characterized in that: described article of everyday use comprises toothpaste, dentifrice, collutory etc., the content of lotus (lotus) plant extract in above-mentioned article of everyday use is at least 0.1%, in the weight of article of everyday use mixture, be good generally with 0.1-10%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101109504A CN101606982A (en) | 2008-06-18 | 2008-06-18 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant |
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| CNA2008101109504A CN101606982A (en) | 2008-06-18 | 2008-06-18 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083212A (en) * | 2013-02-04 | 2013-05-08 | 苏文清 | Salvia miltiorrhiza toothpaste |
| CN104095929A (en) * | 2014-07-29 | 2014-10-15 | 桂林实力科技有限公司 | Decayed-tooth-resistant chewing gum |
| CN112515973A (en) * | 2020-12-17 | 2021-03-19 | 温州医科大学附属口腔医院 | Tooth root canal flushing fluid and preparation method thereof |
-
2008
- 2008-06-18 CN CNA2008101109504A patent/CN101606982A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083212A (en) * | 2013-02-04 | 2013-05-08 | 苏文清 | Salvia miltiorrhiza toothpaste |
| CN103083212B (en) * | 2013-02-04 | 2015-08-19 | 苏文清 | Red sage root toothpaste |
| CN104095929A (en) * | 2014-07-29 | 2014-10-15 | 桂林实力科技有限公司 | Decayed-tooth-resistant chewing gum |
| CN104095929B (en) * | 2014-07-29 | 2016-06-22 | 桂林实力科技有限公司 | Dental caries chewing gum |
| CN112515973A (en) * | 2020-12-17 | 2021-03-19 | 温州医科大学附属口腔医院 | Tooth root canal flushing fluid and preparation method thereof |
| CN112515973B (en) * | 2020-12-17 | 2021-08-20 | 温州医科大学附属口腔医院 | Tooth root canal flushing fluid and preparation method thereof |
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Open date: 20091223 |