CN103083212A - Salvia miltiorrhiza toothpaste - Google Patents
Salvia miltiorrhiza toothpaste Download PDFInfo
- Publication number
- CN103083212A CN103083212A CN2013100430240A CN201310043024A CN103083212A CN 103083212 A CN103083212 A CN 103083212A CN 2013100430240 A CN2013100430240 A CN 2013100430240A CN 201310043024 A CN201310043024 A CN 201310043024A CN 103083212 A CN103083212 A CN 103083212A
- Authority
- CN
- China
- Prior art keywords
- extract
- radix
- toothpaste
- extractum
- pulverize
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a salvia miltiorrhiza toothpaste prepared from the raw materials of, by weight, 5-15 parts of a salvia miltiorrhiza extract, 1-5 parts of a pilose asiabell root extract 1-5 parts of a ginkgo leaf extract, 1-5 parts of a lotus leaf extract, 1-5 parts of a tuber fleeceflower root extract, 1-5 parts of a wenchow turmeric root tuber extract, and 60-90 parts of a toothpaste substrate. The traditional Chinese medicines in the toothpaste provides synergetic effects of blood circulation activating, stasis removing, qi promoting, pain relieving, clear ascending, turbid descending, blood nourishing, and yin nourishing. Through daily teeth brushing, the medicines are dissolved in saliva, and penetrate, diffuse, and are absorbed through mouth mucosa, sublingual capillaries, and meridian points. Medicine breakage caused by gastrointestinal tract, liver, and kidney is avoided, and the medicines can directly enter blood circulation. Therefore, an effect is provided for cardiovascular and cerebrovascular diseases that both the root cause and symptoms are treated. The toothpaste is used for replacing long-term medication of cardiovascular and cerebrovascular disease patients.
Description
Technical field
The present invention relates to a kind of medicated toothpaste, be specifically related to a kind of red sage root toothpaste for the control cardiovascular and cerebrovascular disease, belong to and daily day apply flexibly the product technical field.
Background technology
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular disease and cerebrovascular disease, general reference is sticky due to hyperlipemia, blood, atherosclerosis, hypertension etc. cause heart, brain and body tissue's ischemic or hemorrhage, a kind of serious threat mankind, the commonly encountered diseases of middle-aged and elderly people health more than 50 years old particularly, have the characteristics of " sickness rate is high, disability rate is high, mortality rate is high, relapse rate is high; complication is many ", become the highest No.1 killer of mankind's Death causes.At present, China's Patients with Cardiovascular/Cerebrovascular Diseases has surpassed 2.7 hundred million people, dies from nearly 3,000,000 people of cardiovascular and cerebrovascular disease every year, accounts for 51% of the annual total Death causes of China, and the patient 75% who survives disability in various degree, 40% is heavy residual.
Prevent and treat clinically at present the available medicine of cardiovascular and cerebrovascular disease depressor is arranged: Nifedipine Tablets, ammonia chlorine ground sheet, Telmisartan Tablets, hypertension pill etc., hypolipidemic: simvastatin sheet, Folium Ginkgo, tablets for invigorating circulation and reducing bloodfat etc., coronary heart disease medicine: isosorbide mononitrate sheet, Yixintong dripping pill, lunar caustic heart and brain clearing soft capsule, FUFANG DANSHEN PIAN etc., antithrombotic: Aspirin Enteric-coated Tablets, thrombus-resisting capsules, 'Xue Fu Zhu Yu ' sheet, NAOLUOTONG JIAONANG, Xuesaitong dispersible tablet etc.Therefore the characteristics that have " sickness rate is high, disability rate is high, mortality rate is high, relapse rate is high, and complication is many " due to cardiovascular and cerebrovascular disease need to adhere to taking medicine for a long time, carry out prevention and more rear defence recurrence.Yet, adhere to for a long time taking medicine to the Patients with Cardiovascular/Cerebrovascular Diseases not a duck soup, especially to the gerontal patient, often forget and take medicine, Refuse to take medicine when perhaps health does not have significant discomfort, this has brought challenge all for the control of cardiovascular and cerebrovascular disease.
Toothpaste for cleaning teeth, is protected the daily necessities of oral hygiene as a kind of, and consumer is accustomed to the middle use of brushing teeth in morning every day, evening already.Enhancing along with consumer healthcare's consciousness has proposed more health care demand to toothpaste, expects can prevent and treat certain disease when brushing teeth, such as auxiliary prevention and the chronic diseases such as treatment oral disease and cardiovascular and cerebrovascular disease.Occurred at present the functional toothpaste of a lot of interpolation active ingredient of Chinese herbs in toothpaste market, as pseudo-ginseng toothpaste, shiny pricklyash toothpaste, YUNNAN BAIYAO toothpaste etc., but its effect only rests in control to oral disease.Chinese patent literature CN101112376A discloses a kind of toothpaste for nursing cardiac and cerebral blood vessel, comprises Radix Notoginseng total arasaponins, Borneolum Syntheticum, glycerol, calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulphate, essence, sodium benzoate and distilled water.Radix Notoginseng total arasaponins in this toothpaste direct oral cavity mucosa, Sublingual blood capillary when brushing teeth enter blood, prevention and treatment cardiovascular and cerebrovascular disease there is certain effect, but because effective ingredient is single, limited to the cardiovascular disease prevention effect, can not substitute the Patients with Cardiovascular/Cerebrovascular Diseases Long-term taking medicine, therefore need to research and develop the toothpaste with control cardiovascular and cerebrovascular disease function of better effects if according to theory of Chinese medical science, be used for substituting the Patients with Cardiovascular/Cerebrovascular Diseases Long-term taking medicine.
Summary of the invention
Technical problem to be solved by this invention is to have the toothpaste of control cardiovascular and cerebrovascular disease function in prior art because effective ingredient is single, act on limited, can not substitute the technical problem of Patients with Cardiovascular/Cerebrovascular Diseases Long-term taking medicine, and then a kind of red sage root toothpaste with control cardiovascular and cerebrovascular disease function of better effects if is provided.
For solving the problems of the technologies described above, the invention provides a kind of red sage root toothpaste, the weight portion of this raw material of toothpaste is: Radix Salviae Miltiorrhizae extract 5-15 part, the 1-5 of Radix Codonopsis extract part, Folium Ginkgo extract 1-5 part, Folium Nelumbinis extract 1-5 part, Radix Polygoni Multiflori extract 1-5 part, Radix Curcumae extract 1-5 part, toothpaste are used substrate 60-90 part.
The weight portion of preferred raw material of toothpaste of the present invention is: Radix Salviae Miltiorrhizae extract 8-12 part, and the 2-4 of Radix Codonopsis extract part, Folium Ginkgo extract 2-4 part, Folium Nelumbinis extract 2-4 part, Radix Polygoni Multiflori extract 2-4 part, Radix Curcumae extract 2-4 part, toothpaste is used substrate 68-82 part.
The weight portion of best raw material of toothpaste of the present invention is: 10 parts of Radix Salviae Miltiorrhizae extracts, 3 parts of Radix Codonopsis extracts, 3 parts of Folium Ginkgo extract, 3 parts of Folium Nelumbinis extracts, 3 parts of Radix Polygoni Multiflori extracts, 3 parts of Radix Curcumae extracts, 75 parts of substrate of toothpaste.
Described toothpaste comprises with substrate: abrasivus 15%-50%, wetting agent 5%-35%, foaming agent 1%-5%, thickening agent 0.5%-3%, sweeting agent 0-1%, spice 0-2%, antiseptic 0-0.5%, deionized water 1%-40%, food coloring 0-1.5%.
Described abrasivus is selected from one or more in calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, calcite in powder, leuchtenbergite; Described wetting agent is selected from one or more in glycerol, sorbitol, propylene glycol, Polyethylene Glycol; Described foaming agent is selected from one or more in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium; Described thickening agent is selected from one or more in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, hydroxypropyl guar gum; Described sweeting agent is selected from one or more in sucrose, glucide, cyclamate, xylitol, dipeptide sodium; Described spice is selected from one or more in perilla oil, Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, pentyl acetate; Described antiseptic is selected from one or more in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, sorbitol; Described deionized water is the plastic disperse medium of toothpaste; Described food coloring is green or purple.
Toothpaste of the present invention also comprises the raw material of following weight portion: Rhizoma Alismatis extract 1-3 part, Rhizoma Chuanxiong extract 1-3 part.
Toothpaste of the present invention also comprises the raw material of following weight portion: Pericarpium Citri Reticulatae extract 1-3 part, Radix Angelicae Dahuricae extract 1-3 part, Radix Achyranthis Bidentatae extract 1-3 part.
the weight portion of preferred raw material of toothpaste of the present invention is: 10 parts of Radix Salviae Miltiorrhizae extracts, 3 parts of Radix Codonopsis extracts, 3 parts of Folium Ginkgo extract, 1 part of Folium Nelumbinis extract, 1 part of Radix Polygoni Multiflori extract, 1 part of Radix Curcumae extract, 1 part of Rhizoma Alismatis extract, 1 part of Rhizoma Chuanxiong extract, 1 part of Pericarpium Citri Reticulatae extract, 1 part of Radix Angelicae Dahuricae extract, 1 part of Radix Achyranthis Bidentatae extract, 40 parts of anhydride silicas, 25 parts of Macrogol 2000s, 2 parts of sodium lauryl sulphates, 1 part of carboxymethyl cellulose, 0.2 part of cyclamate, 0.5 part of Oleum menthae, 0.3 part of sodium benzoate, 10.5 parts of deionized waters, 0.5 part of non-polluted edible pigment.
The preparation method of red sage root toothpaste of the present invention comprises the following steps:
(1) with selected red rooted salvia, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(2) with selected codonopsis pilosula, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(3) with selected Folium Ginkgo medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(4) with selected Folium Nelumbinis medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(5) with selected Radix Polygoni Multiflori medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(6) with selected Radix Curcumae medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(7) by the commonly used substrate mix homogeneously of above-mentioned formula ratio with Radix Salviae Miltiorrhizae extractum, Radix Codonopsis extractum, Folium Ginkgo extractum, Radix Polygoni Multiflori extractum, Radix Curcumae extractum and preparation toothpaste, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Another preparation method of red sage root toothpaste of the present invention comprises the following steps:
(1) with selected red rooted salvia, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(2) with selected codonopsis pilosula, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(3) with selected Folium Ginkgo medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(4) with selected Folium Nelumbinis medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(5) with selected Radix Polygoni Multiflori medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(6) with selected Radix Curcumae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(7) with selected Rhizoma Alismatis, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(8) with selected Ligusticum chuanxiong Hort, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(9) with selected Pericarpium Citri Reticulatae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(10) with selected angelica root, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(11) with selected Radix Achyranthis Bidentatae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing;
(12) by the commonly used substrate mix homogeneously of above-mentioned formula ratio with Radix Salviae Miltiorrhizae extractum, Radix Codonopsis extractum, Folium Ginkgo extractum, Radix Polygoni Multiflori extractum, Radix Curcumae extractum, Rhizoma Alismatis extractum, Rhizoma Chuanxiong extractum, Pericarpium Citri Reticulatae extractum, Radix Angelicae Dahuricae extractum, Radix Achyranthis Bidentatae extractum and preparation toothpaste, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Theory of Chinese medical science thinks that cardiovascular and cerebrovascular disease refers to, congestion turbid due to vigour loss, expectorant, the imbalance of the five internal organs negative and positive of qi and blood, be worried in addition angry, drink be satiated with food, the inducements such as sexual life is tired, askew evil invasion and attack, so that QI and blood can not moisten the brain that nourishes heart, and causes a class disease of the not normal and pathological change of cardio cerebral function.It is vigour loss, insufficiency of vital energy and blood, negative and positive loss, its mark is that the stagnation of QI, blood stasis, expectorant are turbid, diseases caused by retention of fluid, performance mostly is simulataneous insufficiency and excessive, cardiovascular symptom and the cerebrovascular symptoms such as dizziness, headache, hypomnesis, sensation and the dyskinesia such as uncomfortable in chest, cardiopalmus, angina pectoris can occur.The void of the vigour deficiency that declines can cause the generation of the pathological products such as expectorant is turbid, congestion, diseases caused by retention of fluid, then causes the cardio-cerebrovascular dysfunction, and is wherein serious with congestion.Qi being the governor of blood, blood being the material foundation of QI; The gas depletion of blood is not deposited, and the blood depletion of QI is not all right; The gas promoting the circulation of blood is gone, and the flourish blood of gas is flourish; Blood wind is from going out.Vigour is sufficient, and cardiac pumping is strong, and blood flow is smooth and easy without hindrance; The vigour loss is not enough, agitates heartbeat and hemodynamic not enough, will form congestion.The integration that clinical treatment is turbid by blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expectorantization, YIN nourishing, YANG invigorating are carried out multipath, many target spots and onset.
The selected Radix Salviae Miltiorrhizae bitter in the mouth of red sage root toothpaste raw material of the present invention, cold nature, GUIXIN, Liver Channel, the effect of tool promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind, modern pharmacology confirms that also it has heart tonifying, coronary artery dilating, increase myocardial flow, antithrombotic formation, improves microcirculation, belongs to monarch drug; Selected Radix Codonopsis sweet in the mouth, property is flat, returns spleen, lung meridian, the effect of tool invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, selected Folium Ginkgo sweet in the mouth, hardship, puckery, property is flat, GUIXIN, lung meridian, the effect of tool blood circulation promoting and blood stasis dispelling, pain relieving belongs to ministerial drug together together with Radix Codonopsis; Selected Folium Nelumbinis bitter in the mouth, suffering, little puckery, cool in nature, GUIXIN, liver, spleen channel, the effect of tool spleen invigorating yang invigorating, the turbid descending, dissipating blood stasis hemostasis reaches blood pressure lowering, blood fat reducing, fat-reducing purpose by ascending the clear and descending the turbid, selected Radix Polygoni Multiflori bitter in the mouth, sweet, puckery, slightly warm in nature is returned liver, kidney channel, the effect of tool enrich and benefit essence and blood, controlling nocturnal emission with astringent drugs kidney tonifying, nourishing the blood and yin, modern pharmacology confirms that it has blood fat reducing and study of anti-atherogenic effect, belongs to adjuvant drug together with Folium Nelumbinis; Selected Radix Curcumae acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, the effect of tool regulating qi to disperse stagnation, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, as making medicine, the performance priming is returned through, the up effect of medicine carrying.Play altogether the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, ascending the clear and descending the turbid, nourishing the blood and yin after the said medicine compatibility, cardiovascular and cerebrovascular disease is had the effect for the treatment of both the principal and secondary aspects of a disease.
For increasing the curative effect of said medicine formula, can also add Rhizoma Alismatis, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae by selectivity.
Rhizoma Alismatis sweet in the mouth, light, cold in nature, return kidney, urinary bladder channel, tool promoting diuresis to eliminate damp pathogen, the treating stranguria effect that expels the heat-evil in diuretic antihypertensive, also have the coronary flow of increasing, antiplatelet aggregation, anti-thrombosis function; The Rhizoma Chuanxiong acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, the effect of tool blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; Pericarpium Citri Reticulatae acrid in the mouth, hardship, warm in nature, return spleen channel, stomach warp, lung meridian, the effect of tool regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, diuretic relieving constipation; Radix Angelicae Dahuricae acrid in the mouth, warm in nature, return lung, spleen, stomach warp, tool expelling wind and removing dampness, logical effect of stealing pain relieving; Radix Achyranthis Bidentatae bitter in the mouth, acid, property is flat, returns liver, kidney channel, the effect of tool invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, inducing diuresis for treating stranguria syndrome.
Technical solutions according to the invention have the following advantages with respect to prior art:
Chinese herbal medicine active component Radix Salviae Miltiorrhizae, Radix Codonopsis, Folium Ginkgo, Folium Nelumbinis, Radix Polygoni Multiflori, the Radix Curcumae of adding in toothpaste of the present invention are to form according to the theory of Chinese medical science compatibility, play altogether the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, ascending the clear and descending the turbid, nourishing the blood and yin, by brushing teeth every day, medicine is dissolved in saliva, oral transmucosal, Sublingual blood capillary and meridian point infiltration, diffusion, absorption, avoid gastrointestinal tract and Liver and kidney to the destruction of medicine, directly enter blood circulation, the effect that cardiovascular and cerebrovascular disease is had treating both the principal and secondary aspects of a disease is used for substituting the Patients with Cardiovascular/Cerebrovascular Diseases Long-term taking medicine.
The specific embodiment
The raw material preparation:
Radix Salviae Miltiorrhizae extract: with selected red rooted salvia, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected red rooted salvia, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Salviae Miltiorrhizae extract.
Radix Codonopsis extract: with selected codonopsis pilosula, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Perhaps with selected codonopsis pilosula, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Codonopsis extract.
Folium Ginkgo extract: with selected Folium Ginkgo medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Folium Ginkgo medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Ginkgo extract.
Folium Nelumbinis extract: with selected Folium Nelumbinis medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Folium Nelumbinis medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Nelumbinis extract.
Radix Polygoni Multiflori extract: with selected Radix Polygoni Multiflori medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Radix Polygoni Multiflori medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Polygoni Multiflori extract.
Radix Curcumae extract: with selected Radix Curcumae medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Radix Curcumae medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Curcumae extract.
Rhizoma Alismatis extract: with selected Rhizoma Alismatis, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Rhizoma Alismatis, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Rhizoma Alismatis extract.
Rhizoma Chuanxiong extract: with selected Ligusticum chuanxiong Hort, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Ligusticum chuanxiong Hort, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Rhizoma Chuanxiong extract.
Pericarpium Citri Reticulatae extract: with selected Pericarpium Citri Reticulatae medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Pericarpium Citri Reticulatae medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Pericarpium Citri Reticulatae extract.
Radix Angelicae Dahuricae extract: with selected angelica root, remove impurity, pulverize, use 50%(V/V) alcohol reflux is 1-3 time, and 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Angelicae Dahuricae extract.
Radix Achyranthis Bidentatae extract: with selected Radix Achyranthis Bidentatae medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing; Or with selected Radix Achyranthis Bidentatae medical material, remove impurity, and pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Achyranthis Bidentatae extract.
Toothpaste substrate: directly buy from market.
Embodiment 1
Take Radix Salviae Miltiorrhizae extract 5g, the 1g of Radix Codonopsis extract, Folium Ginkgo extract 1g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, calcium phosphate dibasic dihydrate 35g, glycerol 15g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, sucrose 0.2g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.1g, deionized water 6.4g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 2
Take Radix Salviae Miltiorrhizae extract 15g, the 5g of Radix Codonopsis extract, Folium Ginkgo extract 5g, Folium Nelumbinis extract 5g, Radix Polygoni Multiflori extract 5g, Radix Curcumae extract 5g, calcium phosphate dibasic dihydrate 50g, glycerol 30g, sodium lauryl sulphate 3g, carboxymethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 5g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 3
Take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 3g, Radix Curcumae extract 3g, anhydride silica 40g, glycerol 25g, sodium lauryl sulphate 2g, carboxyethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 6g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 4
Take Radix Salviae Miltiorrhizae extract 7g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 2g, Radix Curcumae extract 2g, anhydride silica 40g, glycerol 23g, N-sodium lauroyl sarcosine 2g, carboxyethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 5g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 5
Take Radix Salviae Miltiorrhizae extract 12g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, anhydride silica 45g, glycerol 23g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, sucrose 0.5g, lemon sesame oil 0.2g, sodium benzoate 0.2g, deionized water 5g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 6
Take Radix Salviae Miltiorrhizae extract 12g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 2g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 2g, Radix Curcumae extract 1g, anhydride silica 40g, sorbitol 20g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, sucrose 0.5g, lemon sesame oil 0.2g, sodium benzoate 0.2g, deionized water 5g, non-polluted edible pigment 1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 7
Take Radix Salviae Miltiorrhizae extract 12g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 2g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 2g, Radix Curcumae extract 1g, anhydride silica 40g, sorbitol 20g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, sucrose 0.5g, lemon sesame oil 0.2g, sodium benzoate 0.2g, deionized water 6g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 8
Take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 2g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 3g, Radix Curcumae extract 1g, anhydride silica 40g, sorbitol 20g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, lemon sesame oil 0.2g, sodium benzoate 0.2g, deionized water 6g, non-polluted edible pigment 0.5g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 9
Take Radix Salviae Miltiorrhizae extract 12g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 2g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 2g, Radix Curcumae extract 1g, anhydride silica 40g, propylene glycol 22g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, sucrose 0.5g, lemon sesame oil 0.2g, deionized water 5g, non-polluted edible pigment 1g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 10
Take Radix Salviae Miltiorrhizae extract 12g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, anhydride silica 45g, glycerol 23g, N-sodium lauroyl sarcosine 3g, carboxyethyl cellulose 1.5g, lemon sesame oil 0.2g, sodium benzoate 0.2g, deionized water 5g, purple food coloring 0.2g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 11
Take Radix Salviae Miltiorrhizae extract 8g, the 2g of Radix Codonopsis extract, Folium Ginkgo extract 2g; Folium Nelumbinis extract 2g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g; calcium phosphate dibasic anhydrous 35g, propylene glycol 23g, methyl cocoa ester group sodium taurocholate 3g; sodium alginate 1.5g, glucide 0.5g, Oleum Menthae Rotundifoliae 0.2g; potassium sorbate 0.2g, deionized water 10g, non-polluted edible pigment 0.1g; mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 12
Take Radix Salviae Miltiorrhizae extract 12g, the 2g of Radix Codonopsis extract, Folium Ginkgo extract 2g; Folium Nelumbinis extract 2g, Radix Polygoni Multiflori extract 2g, Radix Curcumae extract 1g; calcium pyrophosphate 35g, Macrogol 2000 23g, acyl glutamic acid sodium 3g; yellow gummy powder 1.5g, xylitol 0.5g, orange oil 0.2g; sorbitol 0.2g, deionized water 8g, non-polluted edible pigment 0.2g; mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 13
Take Radix Salviae Miltiorrhizae extract 5g, the 1g of Radix Codonopsis extract, Folium Ginkgo extract 1g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, Rhizoma Alismatis extract 1g, Rhizoma Chuanxiong extract 1g, anhydride silica 35g, glycerol 18g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, sucrose 0.2g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.1g, deionized water 6.4g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 14
Take Radix Salviae Miltiorrhizae extract 15g, the 5g of Radix Codonopsis extract, Folium Ginkgo extract 5g, Folium Nelumbinis extract 5g, Radix Polygoni Multiflori extract 5g, Radix Curcumae extract 5g, Rhizoma Alismatis extract 3g, Rhizoma Chuanxiong extract 3g, calcium phosphate dibasic dihydrate 50g, glycerol 30g, sodium lauryl sulphate 3g, carboxymethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 5g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 15
Take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 3g, Radix Curcumae extract 3g, Rhizoma Alismatis extract 2g, Rhizoma Chuanxiong extract 2g, anhydride silica 40g, glycerol 25g, sodium lauryl sulphate 2g, carboxyethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 6g, non-polluted edible pigment 0.1g, mix homogeneously is placed in the vacuum Manufacturing medicine extract machine and carries out after homogenizing processes, fill and get final product.
Embodiment 16
Take Radix Salviae Miltiorrhizae extract 5g, the 1g of Radix Codonopsis extract, Folium Ginkgo extract 1g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, Pericarpium Citri Reticulatae extract 1g, Radix Angelicae Dahuricae extract 1g, Radix Achyranthis Bidentatae extract 1g, anhydride silica 35g, glycerol 18g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, sucrose 0.2g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.1g, deionized water 6.4g, non-polluted edible pigment 0.1g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 17
Take Radix Salviae Miltiorrhizae extract 15g, the 5g of Radix Codonopsis extract, Folium Ginkgo extract 5g, Folium Nelumbinis extract 5g, Radix Polygoni Multiflori extract 5g, Radix Curcumae extract 5g, Pericarpium Citri Reticulatae extract 3g, Radix Angelicae Dahuricae extract 3g, Radix Achyranthis Bidentatae extract 3g, calcium phosphate dibasic dihydrate 50g, glycerol 30g, sodium lauryl sulphate 3g, carboxymethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 5g, non-polluted edible pigment 0.1g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 18
Take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 3g, Radix Polygoni Multiflori extract 3g, Radix Curcumae extract 3g, Pericarpium Citri Reticulatae extract 2g, Radix Angelicae Dahuricae extract 2g, Radix Achyranthis Bidentatae extract 2g, anhydride silica 40g, glycerol 25g, sodium lauryl sulphate 2g, carboxyethyl cellulose 1g, sucrose 0.5g, Oleum menthae 0.2g, p-Hydroxybenzoate 0.2g, deionized water 6g, non-polluted edible pigment 0.1g, mix homogeneously, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Embodiment 19
take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, Rhizoma Alismatis extract 1g, Rhizoma Chuanxiong extract 1g, Pericarpium Citri Reticulatae extract 1g, Radix Angelicae Dahuricae extract 1g, Radix Achyranthis Bidentatae extract 1g, anhydride silica 40g, Macrogol 2000 25g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, cyclamate 0.2g, Oleum menthae 0.5g, sodium benzoate 0.3g, deionized water 10.5g, non-polluted edible pigment 0.5g, mix homogeneously, being placed in the vacuum Manufacturing medicine extract machine carries out after homogenizing processes, fill and get final product.
Embodiment 20
take Radix Salviae Miltiorrhizae extract 10g, the 3g of Radix Codonopsis extract, Folium Ginkgo extract 3g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, Rhizoma Alismatis extract 2g, Rhizoma Chuanxiong extract 2g, Pericarpium Citri Reticulatae extract 2g, Radix Angelicae Dahuricae extract 2g, Radix Achyranthis Bidentatae extract 2g, anhydride silica 45g, Macrogol 2000 25g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, cyclamate 0.2g, Oleum menthae 0.5g, sodium benzoate 0.3g, deionized water 11g, non-polluted edible pigment 0.5g, mix homogeneously, being placed in the vacuum Manufacturing medicine extract machine carries out after homogenizing processes, fill and get final product.
Embodiment 21
take Radix Salviae Miltiorrhizae extract 15g, the 5g of Radix Codonopsis extract, Folium Ginkgo extract 5g, Folium Nelumbinis extract 1g, Radix Polygoni Multiflori extract 1g, Radix Curcumae extract 1g, Rhizoma Alismatis extract 3g, Rhizoma Chuanxiong extract 3g, Pericarpium Citri Reticulatae extract 3g, Radix Angelicae Dahuricae extract 3g, Radix Achyranthis Bidentatae extract 3g, anhydride silica 45g, Macrogol 2000 25g, sodium lauryl sulphate 2g, carboxymethyl cellulose 1g, cyclamate 0.2g, Oleum menthae 0.5g, sodium benzoate 0.3g, deionized water 10g, non-polluted edible pigment 0.2g, mix homogeneously, being placed in the vacuum Manufacturing medicine extract machine carries out after homogenizing processes, fill and get final product.
Experimental example
In order to show that red sage root toothpaste of the present invention is to the therapeutic effect of cardiovascular and cerebrovascular disease, the present invention is through the clinical observation of 100 routine systems, patients with stable angina pectoris 20 examples wherein, functions in patients with unstable angina 20 examples, Patients with Myocardial Ischemia 20 examples, artrial premature beat patient 20 examples, Patients with Ventricular Premature Beats 20 examples.In the process of above-mentioned clinical observation, and the work of above-mentioned patient being recorded its medical history, the state of an illness, age and curative effect.
The criterion of clinical therapeutic efficacy: with reference to " new Chinese medicine guideline of clinical investigations, angina pectoris (thoracic obstruction) the standard of curative effect evaluation " angina pectoris, electrocardiogram and stagnation of heart-blood syndrome be divided into produce effects, effective, invalid, increase the weight of 4 grades.Arrhythmia is take cardioelectric monitor as standard:
Produce effects: per hour premature beat reduces more than 90%.
Effectively: per hour premature beat reduces more than 80%.
Invalid: as not reach These parameters.
Medication is: the patient brushes teeth with the toothpaste of embodiment 3 preparations, and each 2g brushed teeth 2-5 minute.
The course for the treatment of: 30 days is a course for the treatment of, and sooner or later brush teeth twice every day.
Experimental result shows, only uses this toothpaste of a course for the treatment of, and original symptom obviously alleviates.According to statistics, after using a course for the treatment of, reach 85% obvious effective rate, 15% effective percentage, without invalid with increase the weight of situation (seeing Table 1).
With above-mentioned same method, the oral liquid of embodiment 19 preparations is tested and show, only use this toothpaste of a course for the treatment of, original symptom obviously alleviates.According to statistics, after using a course for the treatment of, reach 90% obvious effective rate, 10% effective percentage, without invalid with increase the weight of situation (seeing Table 2).
Contrast experiment's example
Take Radix Notoginseng total arasaponins 1g, Borneolum Syntheticum 0.5g, glycerol 20g, calcium carbonate 50g, sodium carboxymethyl cellulose 1.4g, sodium lauryl sulphate 2.5g, essence 1g, sodium benzoate 0.05g makes toothpaste according to the disclosed method of aforementioned Chinese patent literature CN101112376A embodiment 1.Use this product to carry out clinic trial to 100 routine patients of identical body constitution, state of an illness state, medication is sooner or later to brush teeth every day 2 times, uses toothpaste 2g at every turn, brushes teeth 2-5 minute, after continuous 30 days, result is as shown in table 3, and its obvious effective rate only has 40%, effective percentage 30%, inefficiency 30% is without increasing the weight of situation.
Although the present invention elaborates it by above-mentioned specific embodiment; but; those skilled in the art should be understood that any form that does not exceed the claim protection domain made on this basis and the variation of details, all belong to invention which is intended to be protected.
Claims (10)
1. a red sage root toothpaste, is characterized in that, the weight portion of this raw material of toothpaste is: Radix Salviae Miltiorrhizae extract 5-15 part, the 1-5 of Radix Codonopsis extract part, Folium Ginkgo extract 1-5 part, Folium Nelumbinis extract 1-5 part, Radix Polygoni Multiflori extract 1-5 part, Radix Curcumae extract 1-5 part, toothpaste is used substrate 60-90 part.
2. red sage root toothpaste according to claim 1, it is characterized in that, the weight portion of described raw material of toothpaste is: Radix Salviae Miltiorrhizae extract 8-12 part, the 2-4 of Radix Codonopsis extract part, Folium Ginkgo extract 2-4 part, Folium Nelumbinis extract 2-4 part, Radix Polygoni Multiflori extract 2-4 part, Radix Curcumae extract 2-4 part, toothpaste are used substrate 68-82 part.
3. red sage root toothpaste according to claim 2, is characterized in that, the weight portion of described raw material of toothpaste is: 10 parts of Radix Salviae Miltiorrhizae extracts, 3 parts of Radix Codonopsis extracts, 3 parts of Folium Ginkgo extract, 3 parts of Folium Nelumbinis extracts, 3 parts of Radix Polygoni Multiflori extracts, 3 parts of Radix Curcumae extracts, 75 parts of substrate of toothpaste.
4. according to claim 1-3 arbitrary described red sage root toothpastes, it is characterized in that, described toothpaste comprises with substrate: abrasivus 15%-50%, wetting agent 5%-35%, foaming agent 1%-5%, thickening agent 0.5%-3%, sweeting agent 0-1%, spice 0-2%, antiseptic 0-0.5%, deionized water 1%-40%, food coloring 0-1.5%.
5. red sage root toothpaste according to claim 4, is characterized in that, described abrasivus is selected from one or more in calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, calcite in powder, leuchtenbergite; Described wetting agent is selected from one or more in glycerol, sorbitol, propylene glycol, Polyethylene Glycol; Described foaming agent is selected from one or more in sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium; Described thickening agent is selected from one or more in sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, hydroxypropyl guar gum; Described sweeting agent is selected from one or more in sucrose, glucide, cyclamate, xylitol, dipeptide sodium; Described spice is selected from one or more in perilla oil, Oleum menthae, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Mentholum, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, pentyl acetate; Described antiseptic is selected from one or more in p-Hydroxybenzoate, sodium benzoate, potassium sorbate, sorbitol; Described deionized water is the plastic disperse medium of toothpaste; Described food coloring is green or purple.
6. red sage root toothpaste according to claim 5, is characterized in that, described toothpaste also comprises the raw material of following weight portion: Rhizoma Alismatis extract 1-3 part, Rhizoma Chuanxiong extract 1-3 part.
7. according to claim 5 or 6 described red sage root toothpastes, is characterized in that, described toothpaste also comprises the raw material of following weight portion: Pericarpium Citri Reticulatae extract 1-3 part, Radix Angelicae Dahuricae extract 1-3 part, Radix Achyranthis Bidentatae extract 1-3 part.
8. red sage root toothpaste according to claim 7, it is characterized in that, the weight portion of described raw material of toothpaste is: 10 parts of Radix Salviae Miltiorrhizae extracts, 3 parts of Radix Codonopsis extracts, 3 parts of Folium Ginkgo extract, 1 part of Folium Nelumbinis extract, 1 part of Radix Polygoni Multiflori extract, 1 part of Radix Curcumae extract, 1 part of Rhizoma Alismatis extract, 1 part of Rhizoma Chuanxiong extract, 1 part of Pericarpium Citri Reticulatae extract, 1 part of Radix Angelicae Dahuricae extract, 1 part of Radix Achyranthis Bidentatae extract, 40 parts of anhydride silicas, 25 parts of Macrogol 2000s, 2 parts of sodium lauryl sulphates, 1 part of carboxymethyl cellulose, 0.2 part of cyclamate, 0.5 part of Oleum menthae, 0.3 part of sodium benzoate, 10.5 parts of deionized waters, 0.5 part of non-polluted edible pigment.
9. the preparation method of according to claim 1-3 arbitrary described red sage root toothpastes, is characterized in that, comprises the following steps:
(1) with selected red rooted salvia, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Salviae Miltiorrhizae extract;
(2) with selected codonopsis pilosula, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Codonopsis extract;
(3) with selected Folium Ginkgo medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Ginkgo extract;
(4) with selected Folium Nelumbinis medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Nelumbinis extract;
(5) with selected Radix Polygoni Multiflori medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Polygoni Multiflori extract;
(6) with selected Radix Curcumae medical material, remove impurity, pulverize, water extraction, concentrated solution is condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Curcumae extract;
(7) by the commonly used substrate mix homogeneously of above-mentioned formula ratio with Radix Salviae Miltiorrhizae extract, Radix Codonopsis extract, Folium Ginkgo extract, Radix Polygoni Multiflori extract, Radix Curcumae extract and preparation toothpaste, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
10. the preparation method of red sage root toothpaste according to claim 7, is characterized in that, comprises the following steps:
(1) with selected red rooted salvia, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Salviae Miltiorrhizae extract;
(2) with selected codonopsis pilosula, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Codonopsis extract;
(3) with selected Folium Ginkgo medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Ginkgo extract;
(4) with selected Folium Nelumbinis medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Folium Nelumbinis extract;
(5) with selected Radix Polygoni Multiflori medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Polygoni Multiflori extract;
(6) with selected Radix Curcumae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Curcumae extract;
(7) with selected Rhizoma Alismatis, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Rhizoma Alismatis extract;
(8) with selected Ligusticum chuanxiong Hort, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Rhizoma Chuanxiong extract;
(9) with selected Pericarpium Citri Reticulatae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Pericarpium Citri Reticulatae extract;
(10) with selected angelica root, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Angelicae Dahuricae extract;
(11) with selected Radix Achyranthis Bidentatae medical material, remove impurity, pulverize, use 50%(V/V) alcohol reflux 1-3 time, 0.5h at every turn, concentrated solution are condensed into the extractum that relative density is 1.10-1.30 after with activated carbon decolorizing, i.e. Radix Achyranthis Bidentatae extract;
(12) by the commonly used substrate mix homogeneously of above-mentioned formula ratio with Radix Salviae Miltiorrhizae extract, Radix Codonopsis extract, Folium Ginkgo extract, Radix Polygoni Multiflori extract, Radix Curcumae extract, Rhizoma Alismatis extract, Rhizoma Chuanxiong extract, Pericarpium Citri Reticulatae extract, Radix Angelicae Dahuricae extract, Radix Achyranthis Bidentatae extract and preparation toothpaste, be placed in the vacuum Manufacturing medicine extract machine and carry out after homogenizing processes, fill and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310043024.0A CN103083212B (en) | 2013-02-04 | 2013-02-04 | Red sage root toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310043024.0A CN103083212B (en) | 2013-02-04 | 2013-02-04 | Red sage root toothpaste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103083212A true CN103083212A (en) | 2013-05-08 |
| CN103083212B CN103083212B (en) | 2015-08-19 |
Family
ID=48196699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310043024.0A Active CN103083212B (en) | 2013-02-04 | 2013-02-04 | Red sage root toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103083212B (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622739A (en) * | 2015-01-12 | 2015-05-20 | 德利宝(广州)香料有限公司 | Toothpaste containing plumeria rubra extract essence and preparation method of toothpaste |
| CN104800112A (en) * | 2015-03-02 | 2015-07-29 | 兰柳生 | Chinese herbal toothpaste |
| CN104971012A (en) * | 2015-07-15 | 2015-10-14 | 昆明理工大学 | Health-care toothpaste containing gamma-aminobutyric acid and preparation method of health-care toothpaste |
| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
| CN106109342A (en) * | 2016-08-17 | 2016-11-16 | 林少英 | A kind of mint flavored toothpaste |
| CN106214591A (en) * | 2016-09-07 | 2016-12-14 | 马鞍山纽盟知识产权管理服务有限公司 | A kind of children special-purpose high-efficiency tooth paste |
| CN108042450A (en) * | 2017-12-24 | 2018-05-18 | 洛阳名力科技开发有限公司 | A kind of Chinese medicine preparation toothpaste |
| CN108096157A (en) * | 2016-11-24 | 2018-06-01 | 陈君君 | A kind of medicine plant toothpaste and preparation method thereof |
| CN110897992A (en) * | 2020-01-02 | 2020-03-24 | 广东立爽生物科技有限公司 | Halitosis removing toothpaste and preparation method thereof |
| CN112315856A (en) * | 2019-11-11 | 2021-02-05 | 冼国茂 | Multifunctional traditional Chinese medicine toothpaste and preparation method thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466443A (en) * | 1994-05-31 | 1995-11-14 | Shu K. Ho | Herbal-based oral composition and process for producing the same |
| CN1345599A (en) * | 2000-09-28 | 2002-04-24 | 国家医药管理局上海医药工业研究院 | Oral cavity bacteriostatic composition containing extract of Chinese herb lotus leaf |
| KR100431170B1 (en) * | 2003-06-11 | 2004-05-12 | 신화제약 (주) | Compositions for Dental Clinic Comprising Extracts of Plant |
| JP2004151002A (en) * | 2002-10-31 | 2004-05-27 | Kansai Koso Kk | Dental plaque staining composition |
| CN1733154A (en) * | 2005-08-18 | 2006-02-15 | 中国人民解放军第四军医大学药物研究所 | Capsule comprising oriental cattail pollen and red sange root and technique for preparing the same |
| CN1788717A (en) * | 2004-12-17 | 2006-06-21 | 上海瑞珀聚合科技发展有限公司 | Fat-reducing and weight reducing toothpaste |
| CN101085024A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and ginkgo leaves and its preparation |
| CN101327177A (en) * | 2007-06-19 | 2008-12-24 | 苏文清 | Red sage root toothpaste |
| CN101606982A (en) * | 2008-06-18 | 2009-12-23 | 湖北汇特生物医药技术有限公司 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant |
| KR20110074223A (en) * | 2009-12-24 | 2011-06-30 | 애경산업(주) | Composition for preventing and improving periodontal disease |
| CN102139084A (en) * | 2011-04-01 | 2011-08-03 | 南京中医药大学 | Chinese medicinal composition for treating fatty liver and preparation method and application thereof |
-
2013
- 2013-02-04 CN CN201310043024.0A patent/CN103083212B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466443A (en) * | 1994-05-31 | 1995-11-14 | Shu K. Ho | Herbal-based oral composition and process for producing the same |
| CN1345599A (en) * | 2000-09-28 | 2002-04-24 | 国家医药管理局上海医药工业研究院 | Oral cavity bacteriostatic composition containing extract of Chinese herb lotus leaf |
| JP2004151002A (en) * | 2002-10-31 | 2004-05-27 | Kansai Koso Kk | Dental plaque staining composition |
| KR100431170B1 (en) * | 2003-06-11 | 2004-05-12 | 신화제약 (주) | Compositions for Dental Clinic Comprising Extracts of Plant |
| CN1788717A (en) * | 2004-12-17 | 2006-06-21 | 上海瑞珀聚合科技发展有限公司 | Fat-reducing and weight reducing toothpaste |
| CN1733154A (en) * | 2005-08-18 | 2006-02-15 | 中国人民解放军第四军医大学药物研究所 | Capsule comprising oriental cattail pollen and red sange root and technique for preparing the same |
| CN101085024A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and ginkgo leaves and its preparation |
| CN101327177A (en) * | 2007-06-19 | 2008-12-24 | 苏文清 | Red sage root toothpaste |
| CN101606982A (en) * | 2008-06-18 | 2009-12-23 | 湖北汇特生物医药技术有限公司 | The application of antimicrobial and antiphlogistic activity composition in lotus (lotus) plant |
| KR20110074223A (en) * | 2009-12-24 | 2011-06-30 | 애경산업(주) | Composition for preventing and improving periodontal disease |
| CN102139084A (en) * | 2011-04-01 | 2011-08-03 | 南京中医药大学 | Chinese medicinal composition for treating fatty liver and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨海荣等: "益肝降脂胶囊治疗高脂血症29例临床观察", 《湖北中医杂志》, vol. 24, 31 December 2002 (2002-12-31), pages 76 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622739A (en) * | 2015-01-12 | 2015-05-20 | 德利宝(广州)香料有限公司 | Toothpaste containing plumeria rubra extract essence and preparation method of toothpaste |
| CN104800112A (en) * | 2015-03-02 | 2015-07-29 | 兰柳生 | Chinese herbal toothpaste |
| CN104971012A (en) * | 2015-07-15 | 2015-10-14 | 昆明理工大学 | Health-care toothpaste containing gamma-aminobutyric acid and preparation method of health-care toothpaste |
| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
| CN106109342A (en) * | 2016-08-17 | 2016-11-16 | 林少英 | A kind of mint flavored toothpaste |
| CN106214591A (en) * | 2016-09-07 | 2016-12-14 | 马鞍山纽盟知识产权管理服务有限公司 | A kind of children special-purpose high-efficiency tooth paste |
| CN108096157A (en) * | 2016-11-24 | 2018-06-01 | 陈君君 | A kind of medicine plant toothpaste and preparation method thereof |
| CN108042450A (en) * | 2017-12-24 | 2018-05-18 | 洛阳名力科技开发有限公司 | A kind of Chinese medicine preparation toothpaste |
| CN112315856A (en) * | 2019-11-11 | 2021-02-05 | 冼国茂 | Multifunctional traditional Chinese medicine toothpaste and preparation method thereof |
| CN110897992A (en) * | 2020-01-02 | 2020-03-24 | 广东立爽生物科技有限公司 | Halitosis removing toothpaste and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103083212B (en) | 2015-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083212B (en) | Red sage root toothpaste | |
| CN103432559B (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN104873705A (en) | Medicinal composition for treating angina pectoris of coronary heart disease and application thereof | |
| CN103040976B (en) | Medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis | |
| CN103007192B (en) | Chinese medicinal composition for treating thoracic obstruction | |
| CN102228648B (en) | Chinese medicinal composition for treating icterohepatitis | |
| CN103977092A (en) | Medicine composition for treating myocardial infarction and cerebral infarction | |
| CN105126034A (en) | Pharmaceutical preparation for treating coronary heart disease | |
| CN103006833B (en) | Medicine for hiatus hernia postoperative rehabilitation | |
| CN102293985A (en) | Traditional Chinese medicine composition used for treating coronary heart disease and preparation method thereof | |
| CN101239128B (en) | Menstruation-regulating face-nourishing Chinese medicinal composition and preparation thereof | |
| CN104873615A (en) | Cinnamon oil containing externally applied medicine for treating traumatic injury | |
| CN1245197C (en) | Chinese medicine preparation for treating coronary heart disease and viral myocarditis | |
| CN103405554B (en) | A kind of medicine for the preoperative bowel relieving of abdominal operation | |
| CN103599485B (en) | A kind of Chinese medicine composition being used for the treatment of premature beat | |
| CN103182035B (en) | Traditional Chinese medicine composition used for treating chronic arrhythmia of elderly people and preparation method of traditional Chinese medicine composition | |
| CN102133332B (en) | Traditional Chinese medicine compound preparation for preventing and curing coronary heart disease and angina and preparation method thereof | |
| CN102018811A (en) | Chinese materia medica preparation for treating urticaria | |
| CN106310137A (en) | Traditional Chinese medicine composition for treating qi stagnation and blood stasis syndrome due to coronary disease and angina and preparation method thereof | |
| CN106074784A (en) | The Chinese medicine for the treatment of coronary heart disease and myocardial ischemia | |
| CN105148182A (en) | Traditional Chinese medicinal pill for treating angina pectoris and preparation method of traditional Chinese medicinal pill | |
| CN104383269A (en) | Traditional Chinese medicine composition for treating coronary heart disease | |
| CN104587190A (en) | Traditional Chinese medicine for treating stenocardia | |
| CN104383270A (en) | Medicine for treating coronary heart diseases | |
| CN104784401A (en) | Traditional Chinese medicine preparation for treating stomach cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |