CN104095929A - Decayed-tooth-resistant chewing gum - Google Patents
Decayed-tooth-resistant chewing gum Download PDFInfo
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- CN104095929A CN104095929A CN201410363586.8A CN201410363586A CN104095929A CN 104095929 A CN104095929 A CN 104095929A CN 201410363586 A CN201410363586 A CN 201410363586A CN 104095929 A CN104095929 A CN 104095929A
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Abstract
The invention provides a decayed-tooth-resistant chewing gum, which comprises a gum base and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-15 parts of siraitia grosvenorii, 1-5 parts of radix glycyrrhizae, 1-3 parts of gallnut, 1-2 parts of radix angelicae dahuricae, 0.5-1.5 parts of mint, 0.5-1 part of clove, 1-3 parts of lotus leaf and 1-3 parts of cortex magnoliae officinalis. According to the invention, the combining capacity of active ingredients in the decayed-tooth-resistant chewing gum and streptococcus mutans is higher, and the active ingredients can directly enter the streptococcus mutans cells to play the effect of killing bacteria.
Description
Technical field
The present invention relates to a kind of chewing gum, be specifically related to a kind of dental caries chewing gum.
Background technology
Dental caries mainly refers to that when sugary food, under Streptococcus mutans effect, glycolysis occurs, the acid producing acts on tooth, makes enamel and dentin destroyed.The anti-caries product of application is roughly divided into following a few class in the market: one for containing fluoride preparation, and its anti-caries raw material, for promoting tooth calcification, reduces sour corrosion, and this is indirect action, and curative effect is limited; The 2nd, the application of antibacterials, povidone iodine as calm and peaceful in mouth, the safe main component of mouth is the materials such as hibitane, metronidazole, glycerol, the safe surface that can be adsorbed on enamel, oral mucosa and dental plaque of mouth, and slowly discharge, there is great broad-spectrum antibacterial, bactericidal action, and can prevent the generation of oral cavity infection, but life-time service can cause the side effect such as tooth flavescence, sense of taste change.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of character gentleness, zest are little, the dental caries chewing gum of safety non-toxic.
Technical scheme provided by the invention is a kind of dental caries chewing gum, comprise gum base and Chinese medicine composition, described Chinese medicine composition is mainly made by the raw material of following weight parts: 8～15 parts of Fructus Momordicaes, 1～5 part, Radix Glycyrrhizae, 1～3 part of Galla Chinensis, 1～2 part of the Radix Angelicae Dahuricae, 0.5～1.5 part of Herba Menthae, 0.5～1 part of Flos Caryophylli, 1～3 part, Folium Nelumbinis.
As preferably, described raw material also comprises the Cortex Magnoliae Officinalis of 1～3 weight portion.
The preparation method of above-mentioned Chinese medicine composition is as follows:
1) Herba Menthae in raw material and Flos Caryophylli are placed in to ethanol, at 80～85 DEG C, reflux, extract, 1～3 time is extracted 0.5～1.5h at every turn, and merge extractive liquid, is centrifugal, filters the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.10～1.25;
2) by remaining raw material pulverizing, soak, decoct 1～3 time at 85～95 DEG C, decoct 1～2h at every turn, merge decoction liquor, filter, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.05～1.15;
3) by step 1) and step 2) extractum mix, to obtain final product.
Above-mentioned Chinese medicine composition accounts for 0.2～2% of this chewing gum weight.
The preparation method of above-mentioned dental caries chewing gum: Chinese medicine composition and gum base are mixed, be heated to its melting at 50～60 DEG C, stir evenly the cooling candy batch that is; Candy batch is rolled into sugar-tablet, and cooling, stripping and slicing, to obtain final product.
Active component in dental caries chewing gum of the present invention and the binding ability of Streptococcus mutans are stronger, thereby cocoa directly enters the effect of playing kill bacteria in Streptococcus mutans cyton.Active component of the present invention is Chinese medicine extract, has advantages of that character gentleness, zest are little, safety non-toxic, can eat for a long time.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
1) batching: Fructus Momordicae 8kg, Radix Glycyrrhizae 1kg, Galla Chinensis 1kg, Radix Angelicae Dahuricae 1kg, Herba Menthae 0.5kg, Flos Caryophylli 0.5kg, Folium Nelumbinis 1kg.
2) Herba Menthae and Flos Caryophylli are placed in to ethanol, at 80 DEG C, reflux, extract, 0.5h, centrifugal by extracting solution, filters the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.10;
3) by remaining raw material pulverizing, soak, at 85 DEG C, decoct 1h, decoction liquor is filtered, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.05;
4) by step 2) and step 3) extractum mix, be Chinese medicine composition;
5) Chinese medicine composition 0.2kg and gum base 99.8kg are mixed, at 50～60 DEG C, be heated to its melting, stir evenly the cooling candy batch that is; Candy batch is rolled into sugar-tablet, and cooling, stripping and slicing, to obtain final product.
Embodiment 2
1) batching: Fructus Momordicae 15kg, Radix Glycyrrhizae 5kg, Galla Chinensis 3kg, Radix Angelicae Dahuricae 2kg, Herba Menthae 1.5kg, Flos Caryophylli 1kg, Folium Nelumbinis 3kg.
2) Herba Menthae and Flos Caryophylli are placed in to ethanol, at 85 DEG C, reflux, extract, 3 times is extracted 1.5h at every turn, and merge extractive liquid, is centrifugal, filters the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.25;
3) by remaining raw material pulverizing, soak, decoct 3 times at 95 DEG C, decoct 2h at every turn, merge decoction liquor, filter, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.15;
4) by step 2) and step 3) extractum mix, be Chinese medicine composition;
5) Chinese medicine composition 2kg and gum base 98kg are mixed, at 60 DEG C, be heated to its melting, stir evenly the cooling candy batch that is; Candy batch is rolled into sugar-tablet, and cooling, stripping and slicing, to obtain final product.
Embodiment 3
1) batching: Fructus Momordicae 8kg, Radix Glycyrrhizae 5kg, Galla Chinensis 1kg, Radix Angelicae Dahuricae 2kg, Herba Menthae 0.5kg, Flos Caryophylli 1kg, Folium Nelumbinis 1kg, Cortex Magnoliae Officinalis 3kg.
2) Herba Menthae and Flos Caryophylli are placed in to ethanol, at 80 DEG C, reflux, extract, 3 times is extracted 0.5h at every turn, and merge extractive liquid, is centrifugal, filters the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.25;
3) by remaining raw material pulverizing, soak, decoct 3 times at 85 DEG C, decoct 1h at every turn, merge decoction liquor, filter, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.15;
4) by step 2) and step 3) extractum mix, be Chinese medicine composition;
5) Chinese medicine composition 0.2kg and gum base are mixed, at 60 DEG C, be heated to its melting, stir evenly the cooling candy batch that is; Candy batch is rolled into sugar-tablet, and cooling, stripping and slicing, to obtain final product.
Embodiment 4
1) batching: Fructus Momordicae 15kg, Radix Glycyrrhizae 1kg, Galla Chinensis 3kg, Radix Angelicae Dahuricae 1kg, Herba Menthae 1.5kg, Flos Caryophylli 0.5kg, Folium Nelumbinis 3kg, Cortex Magnoliae Officinalis 1kg.
2) Herba Menthae and Flos Caryophylli are placed in to ethanol, reflux, extract, 1.5h at 85 DEG C, merge extractive liquid,, centrifugal, filter the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.25;
3) by remaining raw material pulverizing, soak, decoct 3 times at 85 DEG C, decoct 1h at every turn, merge decoction liquor, filter, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.15;
4) by step 2) and step 3) extractum mix, be Chinese medicine composition;
5) Chinese medicine composition 0.2kg and gum base are mixed, at 60 DEG C, be heated to its melting, stir evenly the cooling candy batch that is; Candy batch is rolled into sugar-tablet, and cooling, stripping and slicing, to obtain final product.
Experimental example (extracorporeal bacteria inhibitor test)
1, experimental technique:
1) after the chewing gum 1g that gets respectively embodiment 1～4 pulverizes, add 10ml sterilized water and be made into mixed solution.Getting in addition commercially available benefit reaches after sugar-free xylitol 1g pulverizes and adds 10ml sterilized water and be made into mixed solution.
2) preparation of bacteria inhibition tablet: get aseptic and dry filter paper, every drips 20 μ l, then filter paper is lain against in clean aseptic plane ware, uncaps to put in incubator (37 DEG C) and dries, or put under room temperature for subsequent use after natural drying.The preparation of negative control group bacteria inhibition tablet: get aseptic dry filter paper sheet, every drips sterile distilled water 2020 μ l, dry rear for subsequent use.
3) inoculation Streptococcus mutans: dipping concentration with sterile cotton swab is 5 × 105～5 × 106cfu/ml Streptococcus mutans bacteria suspension, evenly smear 3 times at nutrient agar planar surface, often smear once, 60 ° of dull and stereotyped rotations, finally cotton swab is smeared one week around plate edge, build plate, put drying at room temperature 5min.
4) bacteria inhibition tablet is placed with: be placed with a microbiological contamination flat board, each flat board is placed with 4 bacteria inhibition tablets and 1 negative and positive contrast bacteria inhibition tablet at every turn.Be placed with in planar surface with aseptic nipper coupongs, between each print center at a distance of more than 25mm, with dull and stereotyped periphery at a distance of more than 15mm.After being placed with, with the light pressure-like sheet of aseptic nipper, make it be close to planar surface, build plate, be placed in 37 DEG C of incubators and cultivate 16～18h, with diameter (comprising paster) the record of the antibacterial ring of vernier caliper measurement, experiment in triplicate.
2, experimental result
| ? | Inhibition zone (mm) |
| Embodiment 1 | 11.8 |
| Embodiment 2 | 12.9 |
| Embodiment 3 | 14.5 |
| Embodiment 4 | 14.3 |
| Negative control group | 8.3 |
Claims (4)
1. dental caries chewing gum, comprise gum base and Chinese medicine composition, it is characterized in that: described Chinese medicine composition is mainly made by the raw material of following weight parts: 8～15 parts of Fructus Momordicaes, 1～5 part, Radix Glycyrrhizae, 1～3 part of Galla Chinensis, 1～2 part of the Radix Angelicae Dahuricae, 0.5～1.5 part of Herba Menthae, 0.5～1 part of Flos Caryophylli, 1～3 part, Folium Nelumbinis.
2. dental caries chewing gum according to claim 1, is characterized in that: described raw material also comprises the Cortex Magnoliae Officinalis of 1～3 weight portion.
3. dental caries chewing gum according to claim 1 and 2, is characterized in that: the preparation method of described Chinese medicine composition is as follows:
1) Herba Menthae in raw material and Flos Caryophylli are placed in to ethanol, at 80～85 DEG C, reflux, extract, 1～3 time is extracted 0.5～1.5h at every turn, and merge extractive liquid, is centrifugal, filters the extractum that when filtrate decompression is concentrated into 60 DEG C, relative density is 1.10～1.25;
2) by remaining raw material pulverizing, soak, decoct 1～3 time at 85～95 DEG C, decoct 1～2h at every turn, merge decoction liquor, filter, filtrate adds ethanol precipitation, elimination precipitation, the extractum that while being evaporated to 60 DEG C, relative density is 1.05～1.15;
3) by step 1) and step 2) extractum mix, to obtain final product.
4. dental caries chewing gum according to claim 1 and 2, is characterized in that: described Chinese medicine composition accounts for 0.2～2% of this chewing gum weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410363586.8A CN104095929B (en) | 2014-07-29 | 2014-07-29 | Dental caries chewing gum |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410363586.8A CN104095929B (en) | 2014-07-29 | 2014-07-29 | Dental caries chewing gum |
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| CN104095929A true CN104095929A (en) | 2014-10-15 |
| CN104095929B CN104095929B (en) | 2016-06-22 |
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| CN201410363586.8A Active CN104095929B (en) | 2014-07-29 | 2014-07-29 | Dental caries chewing gum |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105053493A (en) * | 2015-07-14 | 2015-11-18 | 界首市兆龙食品有限公司 | Tooth care chewing gum |
| CN105767438A (en) * | 2016-03-08 | 2016-07-20 | 漯河医学高等专科学校 | Chewing gums for preserving oral health and preventing oral diseases |
| CN106858027A (en) * | 2017-04-11 | 2017-06-20 | 明光市外泰高分子材料有限公司 | A kind of concave convex rod chewing gum and preparation method thereof |
| CN107412447A (en) * | 2017-10-06 | 2017-12-01 | 佛山文森特知识产权服务有限公司 | A kind of Fu tea perfumes mouth sugar of anti-caries tooth |
| CN109419948A (en) * | 2017-08-26 | 2019-03-05 | 陈璇 | A kind of Chinese medicine tooth-protective chewing gum and preparation method thereof |
| CN112385731A (en) * | 2020-12-05 | 2021-02-23 | 福建金百利食品实业有限公司 | Formula of non-cariogenic candy and preparation process thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105053493A (en) * | 2015-07-14 | 2015-11-18 | 界首市兆龙食品有限公司 | Tooth care chewing gum |
| CN105767438A (en) * | 2016-03-08 | 2016-07-20 | 漯河医学高等专科学校 | Chewing gums for preserving oral health and preventing oral diseases |
| CN106858027A (en) * | 2017-04-11 | 2017-06-20 | 明光市外泰高分子材料有限公司 | A kind of concave convex rod chewing gum and preparation method thereof |
| CN109419948A (en) * | 2017-08-26 | 2019-03-05 | 陈璇 | A kind of Chinese medicine tooth-protective chewing gum and preparation method thereof |
| CN107412447A (en) * | 2017-10-06 | 2017-12-01 | 佛山文森特知识产权服务有限公司 | A kind of Fu tea perfumes mouth sugar of anti-caries tooth |
| CN112385731A (en) * | 2020-12-05 | 2021-02-23 | 福建金百利食品实业有限公司 | Formula of non-cariogenic candy and preparation process thereof |
| CN112385731B (en) * | 2020-12-05 | 2023-08-18 | 福建金百利食品实业有限公司 | Formula of non-cariogenic candy and preparation process thereof |
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| CN104095929B (en) | 2016-06-22 |
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