CN105434262A - Largetrifoliolious-bugbane-rhizome toothpaste - Google Patents
Largetrifoliolious-bugbane-rhizome toothpaste Download PDFInfo
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- rhizoma cimicifugae
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 66
- 239000000606 toothpaste Substances 0.000 title claims abstract description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 235000005301 cimicifuga racemosa Nutrition 0.000 claims abstract description 33
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000009670 cang er zi wan Substances 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 17
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 12
- 239000005770 Eugenol Substances 0.000 claims abstract description 12
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 12
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 12
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229960002217 eugenol Drugs 0.000 claims abstract description 12
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 12
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 12
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 12
- 239000000600 sorbitol Substances 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims description 49
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
- 241000411851 herbal medicine Species 0.000 claims description 37
- 241000906543 Actaea racemosa Species 0.000 claims description 32
- 238000000605 extraction Methods 0.000 claims description 30
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 24
- 239000001569 carbon dioxide Substances 0.000 claims description 24
- 238000000227 grinding Methods 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 21
- 239000000706 filtrate Substances 0.000 claims description 18
- 239000013521 mastic Substances 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 11
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 9
- 239000003292 glue Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 206010013786 Dry skin Diseases 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 4
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- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 229940081974 saccharin Drugs 0.000 abstract 1
- 235000019204 saccharin Nutrition 0.000 abstract 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
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- 229920000742 Cotton Polymers 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 241000206501 Actaea <angiosperm> Species 0.000 description 1
- 235000007650 Aralia spinosa Nutrition 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000949456 Zanthoxylum Species 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- 230000035876 healing Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
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- 238000011081 inoculation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Cosmetics (AREA)
Abstract
The invention relates to largetrifoliolious-bugbane-rhizome toothpaste, and especially relates to a preparation method for the toothpaste. The toothpaste comprises, in parts by mass, 20-25 parts of largetrifoliolious bugbane rhizmome, 12-15 parts of rhizoma phragmitis, 3 parts of rhizoma coptidis, 5 parts of rhizoma fagopyri dibotryis, 7-10 parts of radix aristolochiae, 5 parts of fructus xanthii, 6-10 parts of plantain seed, 1-2 parts of hydroxyethyl cellulose, 10-15 parts of sodium dodecyl sulfate, 15-30 parts of sorbitol, 0.5 part of eugenol, 0.05-0.1 part of saccharin, 20-30 parts of silicon dioxide, and 95-110 parts of water. The toothpaste is capable of resisting bacteria and diminishing inflammation and protecting health of oral cavity, the preparation technology is simple, and production cost is low.
Description
Technical field
The present invention relates to a kind of Rhizoma Cimicifugae toothpaste, particularly its preparation method and Rhizoma Cimicifugae extract is applied easily antibacterial.
Background technology
Toothpaste is one of most popular article of everyday use, and the use of early stage toothpaste is mainly in order to maintain oral cavity fresh and cool health, teeth whitening, and along with the development of society, toothpaste, for consumers, is not limited to this.Subsidiary effect of toothpaste has become the leading indicator of toothpaste occuping market share.
Now, toothpaste kind has a variety of, such as toothpaste with fluoride, can anti-inflammation; Chinese herbal toothpaste, for oral disease, fast treating; Compound recipe herbaceous toothpaste, repairs oral injury etc. fast; Representational toothpaste brand has Darlie, Chinese toothpaste, Herba Pileae Scriptae toothpaste, mica filled polypropylene, shiny pricklyash toothpaste etc.
According to statistics, consumer generally believes, the toothpaste used at present, and effect is poor, and the toothpaste effect of whitening targetedly or treatment oral disease is slow, and the cycle is long; Chinese herbal medicine or compound recipe herbaceous toothpaste, effect is relatively obvious, but price is higher.
Rhizoma Cimicifugae is the famous conventional Chinese medicine of China, and underground rhizome is used as medicine, in China, the medical value of Rhizoma Cimicifugae is just on the books in Shennong's Herbal, and be listed in " top grade " medical material, have the effect such as heat-clearing and toxic substances removing, bactericidal antiphlogistic, among the people being mainly used in treats toothache, headache, throat pain etc.
At present, all many to the research of Rhizoma Cimicifugae both at home and abroad, the U.S., Germany just have studied the effect of Rhizoma Cimicifugae extract in the various disease for the treatment of before 100 years, and Rhizoma Cimicifugae extract is prepared into various medicine, have alleviate climacteric syndrome medicament, have for the preparation of because virus or bacteriological infection are to sick healing potion etc., in recent years, the domestic research for Rhizoma Cimicifugae also achieves very big breakthrough, discloses the application of Rhizoma Cimicifugae in antitumor drug in China Patent No. 201310104160.6 " a kind of Cimicifuga triterpenoid compound and application thereof ".
Visible, the pharmacological research of Rhizoma Cimicifugae and value high, but at present, Rhizoma Cimicifugae is as medicament raw material, and extracting method mostly is decocting, and extraction ratio is low, and extract is impure, and the applied research of Rhizoma Cimicifugae in toothpaste was also less met in addition.
Summary of the invention
For overcoming the above problems, the object of this invention is to provide a kind of Rhizoma Cimicifugae toothpaste, can not only anti-inflammation, protection oral cavity Jiang Kang, and preparation technology is simple, and production cost is low.
Another object of the present invention is to provide a kind of preparation method of Rhizoma Cimicifugae extract, and extraction efficiency is high, and extract purity is high, and technique is simple.
Another object of the present invention is to provide the application of a kind of Rhizoma Cimicifugae toothpaste at antibiosis.
Technical scheme of the present invention is:
A kind of Rhizoma Cimicifugae toothpaste, Rhizoma Cimicifugae 20-25 part, Rhizoma Phragmitis 12-15 part, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 7-10 part, Fructus Xanthii 5 parts, Herba Plantaginis core 6-10 part, hydroxyethyl-cellulose 1-2 part is comprised in mass ratio in its composition, sodium lauryl sulfate 10-15 part, sorbitol 15-30 part, eugenol 0.5 part, glucide 0.05-0.1 part, silicon dioxide 20-30 part, water 95-110 part.
A kind of Rhizoma Cimicifugae toothpaste, wherein, Rhizoma Cimicifugae adopts supercritical carbon dioxide extraction method.
A kind of Rhizoma Cimicifugae toothpaste, wherein, Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core adopt decocting extraction.
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 60%-75% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 60%-75% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 40-45 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2-3.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1-2MPa, temperature is 90-100 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.12-1.15, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1-2 part, sodium lauryl sulfate 10-15 part, sorbitol 15-30 part, eugenol 0.5 part, water 95-110 part, put into glue pot, stir, add glucide 0.05-0.1 part again, be stirred to translucent, then 1-2h is left standstill, add the Chinese herbal medicine extract dry powder that step (1) and step (2) are obtained again, wherein the silicon dioxide of Rhizoma Cimicifugae 20-25 part, Rhizoma Phragmitis 12-15 part, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 7-10 part, Fructus Xanthii 5 parts, Herba Plantaginis core 6-10 part and 20-30 part; Stir 1-2h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Advantage of the present invention is:
1. can effective anti-inflammation;
2. Rhizoma Cimicifugae extraction process is simple, and extraction efficiency is high;
3. production technology is simple, and cost is low.
Detailed description of the invention
Embodiment 1
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 68% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 68% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 42 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1.5MPa, temperature is 95 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.14, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1.5 parts, sodium lauryl sulfate 12 parts, sorbitol 20 parts, eugenol 0.5 part, 100 parts, water, put into glue pot, stir, then add 0.08 part, glucide, be stirred to translucent, then leave standstill 1.5h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 23 parts, Rhizoma Phragmitis 14 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 8 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 8 parts and the silicon dioxide of 25 parts; Stir 1.5h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 2
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 60% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 60% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 45 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 2MPa, temperature is 100 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.12, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 2 parts, sodium lauryl sulfate 15 parts, sorbitol 30 parts, eugenol 0.5 part, 95 parts, water, put into glue pot, stir, then add 0.1 part, glucide, be stirred to translucent, then leave standstill 2h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 25 parts, Rhizoma Phragmitis 12 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 10 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 6 parts and the silicon dioxide of 30 parts; Stir 2h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 3
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 75% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 75% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 40 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 3.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1MPa, temperature is 90 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.15, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1 part, sodium lauryl sulfate 10 parts, sorbitol 15 parts, eugenol 0.5 part, 110 parts, water, put into glue pot, stir, then add 0.05 part, glucide, be stirred to translucent, then leave standstill 1h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 20 parts, Rhizoma Phragmitis 15 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 7 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 10 parts and the silicon dioxide of 20 parts; Stir 1h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 4
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(2) by hydroxyethyl-cellulose 1.5 parts, sodium lauryl sulfate 13 parts, sorbitol 25 parts, eugenol 0.5 part, 105 parts, water, put into glue pot, stir, then add 0.06 part, glucide, be stirred to translucent, then leave standstill 1h, then add the obtained Chinese herbal medicine extract dry powder of step (1), wherein Rhizoma Phragmitis 13 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 9 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 7 parts and the silicon dioxide of 25 parts; Stir 1h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 5
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 70% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 70% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 43 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1MPa, temperature is 95 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.13, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1.5 parts, sodium lauryl sulfate 14 parts, sorbitol 18 parts, eugenol 0.5 part, 100 parts, water, put into glue pot, stir, then add 0.07 part, glucide, be stirred to translucent, then leave standstill 1h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 19 parts, Rhizoma Phragmitis 11 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 6 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 5 parts and the silicon dioxide of 25 parts; Stir 2h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 6
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 65% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 65% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 44 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 3h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 2MPa, temperature is 98 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.13, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 2 parts, sodium lauryl sulfate 11 parts, sorbitol 18 parts, eugenol 0.5 part, 100 parts, water, put into glue pot, stir, then add 0.08 part, glucide, be stirred to translucent, then leave standstill 1.5h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 26 parts, Rhizoma Phragmitis 16 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 11 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 11 parts and the silicon dioxide of 24 parts; Stir 1.5h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
Embodiment 7
Bacterial restrain is tested:
1. the toothpaste respectively obtained by Example 1-6 and conventional toothpaste 10g are dissolved in 10ml sterilized water, obtain 110 DEG C of sterilizations 1 hour, obtain antibacterial liquid after dissolving completely;
2. the preparation of bacteria inhibition tablet: get 7 aseptic and filter papers of drying, every sheet drips 30 μ l step 1 gained antibacterial liquids, and corresponding embodiment 1-6 and conventional toothpaste label 1 group, 2 groups, 3 groups, 4 groups, 5 groups, 6 groups, 7 groups, again filter paper is put into sterilized petri dishes, diameter 5mm is cut into respectively after natural drying, the thick disk being no more than 4mm, often organizes 3;
3. contrast the preparation of print: get 1 aseptic and filter paper of drying, every sheet drips 30 μ l distilled water, label 8 groups, then filter paper is put into sterilized petri dishes, is cut into the disk 3 of equal size in above-mentioned 2 after natural drying;
4. the inoculation of test organisms: dipping concentration with sterile cotton swab is 5 × 10
5cfu/ml ~ 5 × 10
6cfu/ml staphylococcus aureus bacteria suspension, nutrient agar planar surface uniform application 3 times, often smears 1 time, flat board should rotate 60 °, finally cotton swab is smeared one week around plate edge, builds plate, put drying at room temperature 5min, prepare 8 microbiological contamination plates altogether;
5. brassboard: 1 group 3 disk aseptic nipper coupongs obtained in step 2 are placed with on microbiological contamination plate obtained in step 4, more than distance 30mm between each print center, with microbiological contamination plate circumferential edges at a distance of more than 15mm, after being placed with, build plate, put 37 DEG C of incubators, after cultivating 20h, measure the diameter of bacterial restrain;
6. the 2-7 group obtained in step 2 and in step 3 and 8 groups are processed with step 4;
Result is as follows:
The judgement of bacteriostasis: inhibition zone diameter is greater than 7mm person, has been judged to fungistatic effect, less than or equal to 7mm person, is judged to without bacteriostasis, and in every component, 3 samples all have bacteriostasis to be qualified;
Conclusion: the toothpaste prepared for embodiment 1-3 that group number 1-3 group uses, its component and content are all within the scope of the invention, visible, all there is fungistatic effect, and contrast 7 groups, effect is improved, and wherein embodiment 1 is most preferably scheme, the toothpaste prepared for embodiment 4-6 that group number 4-6 group uses, its component or content is not within the scope of the invention, contrast groups 7 is visible, and fungistatic effect declines, and wherein group number 4 is the toothpaste not adding Rhizoma Cimicifugae extract, decline the most obvious, group 8 is matched group, 3 all without fungistatic effect, experiment conclusion is reliable.
Embodiment 8
1. the toothpaste respectively obtained by Example 1-6 and conventional toothpaste 30g, be dissolved in 100ml water, obtains injection after dissolving, mark 1-7 group;
2. 40 mices are divided into 1-8 group at random, often organize 5, carry out labelling, wherein 1-7 group injects 10ml step 1 gained injection respectively, 8 groups of injection 10ml normal saline;
3. after administration 30min, respectively at each group of mouse right ear tow sides uniform application 0.04ml dimethylbenzene, after causing scorching 1 hour, neck is drawn to put to death, cut each group of mice ears, measure the average swelling rate of various mouse ear, wherein swelling rate=(auris dextra weight-left ear weight)/left ear weight × 100%;
Result is as following table:
Conclusion: group number 1-7 and group 8 are contrasted, known, the toothpaste obtained by embodiment 1-6 and conventional toothpaste all have antiinflammation, group number 1-6 and group 7 are contrasted, known, toothpaste prepared by embodiment 1-3, all within the scope of the present invention, anti-inflammatory effects is better than conventional toothpaste for component and content, and embodiment 1 is preferred version, toothpaste prepared by embodiment 4-6, component or content is not within the scope of the invention, and anti-inflammatory effects is not as conventional toothpaste.
Claims (5)
1. a Rhizoma Cimicifugae toothpaste, it is characterized in that: in its composition, comprise Rhizoma Cimicifugae 20-25 part, Rhizoma Phragmitis 12-15 part, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 7-10 part, Fructus Xanthii 5 parts, Herba Plantaginis core 6-10 part, hydroxyethyl-cellulose 1-2 part in mass ratio, sodium lauryl sulfate 10-15 part, sorbitol 15-30 part, eugenol 0.5 part, glucide 0.05-0.1 part, silicon dioxide 20-30 part, water 95-110 part.
2. a kind of Rhizoma Cimicifugae toothpaste according to claim 1, is characterized in that: wherein, and Rhizoma Cimicifugae adopts supercritical carbon dioxide extraction method.
3. a kind of Rhizoma Cimicifugae toothpaste according to claim 1, is characterized in that: wherein, and Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core adopt decocting extraction.
4. a kind of Rhizoma Cimicifugae toothpaste according to claim 1, is characterized in that:
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 60%-75% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 60%-75% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 40-45 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2-3.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1-2MPa, temperature is 90-100 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.12-1.15, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1-2 part, sodium lauryl sulfate 10-15 part, sorbitol 15-30 part, eugenol 0.5 part, water 95-110 part, put into glue pot, stir, add glucide 0.05-0.1 part again, be stirred to translucent, then 1-2h is left standstill, add the Chinese herbal medicine extract dry powder that step (1) and step (2) are obtained again, wherein the silicon dioxide of Rhizoma Cimicifugae 20-25 part, Rhizoma Phragmitis 12-15 part, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 7-10 part, Fructus Xanthii 5 parts, Herba Plantaginis core 6-10 part and 20-30 part; Stir 1-2h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
5. a kind of Rhizoma Cimicifugae toothpaste according to claim 4, is characterized in that:
A kind of preparation method of Rhizoma Cimicifugae toothpaste:
(1) by Rhizoma Cimicifugae with after clean water 2 times, put into dismembyator, add the 68% ethanol grinding that weight is 1 times, Rhizoma Cimicifugae after grinding is poured in 100 mesh sieve, collection is sieved ethanol and Largetrifoliolious Bugbane Rhizome, unsifted Rhizoma Cimicifugae is put into dismembyator, add the 68% ethanol continuation grinding that weight is 1 times, to Rhizoma Cimicifugae completely by 100 mesh sieve, collection is sieved liquid, filter, obtain Largetrifoliolious Bugbane Rhizome, Largetrifoliolious Bugbane Rhizome is put into thermostatic drying chamber, 70 DEG C of dryings are after 30 minutes, Largetrifoliolious Bugbane Rhizome is put into supercritical carbon dioxide extraction tank, regulate pressure and the temperature of extractor, and to control extractor pressure be 20MPa, temperature is 42 DEG C, pass into supercritical carbon dioxide to extract, extraction time is 2.5h, after extraction, supercritical carbon dioxide containing extract is passed in separating still, wherein separating still pressure is 1.5MPa, temperature is 95 DEG C, when the supercritical carbon dioxide in extraction kettle enters after separating still is separated completely, be separated and terminate, collect extract in separating still, being concentrated into relative density is 1.14, obtain powdered Rhizoma Cimicifugae extract,
(2) respectively Rhizoma Phragmitis, Rhizoma Coptidis, Rhizoma Fagopyri Dibotryis, Radix Aristolochiae, Fructus Xanthii, Herba Plantaginis core are put into dismembyator and ground, add the water that weight is 2 times, grind after 20 minutes, Chinese herbal medicine in dismembyator is transferred in pot, be incorporated as 5 times of distilled water of Chinese herbal medicine gross weight again, 100 DEG C decoct after 2 hours, are cooled to 70 DEG C, continue decoction after 1 hour, cooling, filters, and collects filtrate, filtrate being concentrated into relative density is 1.10, obtains powdered Chinese herbal medicine extract;
(3) by hydroxyethyl-cellulose 1.5 parts, sodium lauryl sulfate 12 parts, sorbitol 20 parts, eugenol 0.5 part, 100 parts, water, put into glue pot, stir, then add 0.08 part, glucide, be stirred to translucent, then leave standstill 1.5h, then add the Chinese herbal medicine extract dry powder that step (1) and step (2) obtain, wherein Rhizoma Cimicifugae 23 parts, Rhizoma Phragmitis 14 parts, Rhizoma Coptidis 3 parts, Rhizoma Fagopyri Dibotryis 5 parts, Radix Aristolochiae 8 parts, Fructus Xanthii 5 parts, Herba Plantaginis core 8 parts and the silicon dioxide of 25 parts; Stir 1.5h, obtain mastic, then after mastic is ground by grinder, obtained toothpaste.
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| CN201510966143.2A CN105434262A (en) | 2015-12-22 | 2015-12-22 | Largetrifoliolious-bugbane-rhizome toothpaste |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109347A (en) * | 2016-08-17 | 2016-11-16 | 娄尤来 | A kind of Rhizoma Cimicifugae Folium Nelumbinis toothpaste |
| CN110755277A (en) * | 2019-12-05 | 2020-02-07 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
-
2015
- 2015-12-22 CN CN201510966143.2A patent/CN105434262A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109347A (en) * | 2016-08-17 | 2016-11-16 | 娄尤来 | A kind of Rhizoma Cimicifugae Folium Nelumbinis toothpaste |
| CN110755277A (en) * | 2019-12-05 | 2020-02-07 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN110755277B (en) * | 2019-12-05 | 2022-08-09 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
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Application publication date: 20160330 |