CN110115737A - Plant the application on tooth Chinese medicine nursing liquid, preparation method and plant tooth - Google Patents
Plant the application on tooth Chinese medicine nursing liquid, preparation method and plant tooth Download PDFInfo
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- CN110115737A CN110115737A CN201910456303.7A CN201910456303A CN110115737A CN 110115737 A CN110115737 A CN 110115737A CN 201910456303 A CN201910456303 A CN 201910456303A CN 110115737 A CN110115737 A CN 110115737A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention discloses the applications on tooth-implanting Chinese medicine nursing liquid, preparation method and plant tooth, the preparation method comprises the following steps: (1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis is respectively crushed into 5-50 mesh, mixed, fermentation, it extracts, obtains plant extraction liquid；(2) take plant extraction liquid, corrigent, hydroxypropyl-β-cyclodextrin super molecule inclusion compound, glycerol be added to the water be uniformly mixed to get.Honeysuckle of the present invention, aloe, green tea, granatum, Schisandra chinensis have the function of sterilization, anti-inflammatory；The present invention plants tooth Chinese medicine nursing liquid, and safe and non-stimulating, ingredient is natural, can there is effective fresh breath, sterilization, anti-inflammatory, detumescence, the oral care after can be used for planting tooth, and the oral health for improving people is horizontal.
Description
Technical field
The present invention relates to Chinese medicine nursing liquid technical fields, and in particular to tooth-implanting Chinese medicine nursing liquid, preparation method and
Plant the application on tooth.
Background technique
The ora, disinfectant clinically applied is mainly by iodine class, antibiotics, acid-base class or chlorohexidene class at present.Iodine
Ionic oxide formation is very competent, but is a kind of unstable material, and is easy to other materials and generates color change, while generating and sinking
It forms sediment, sterilization also decreases；Antibiotics such as nitrofurazone, poor taste and is easy to produce biocidal property；Acid-base class or
Its is at high cost for chlorohexidene class, germicidal efficiency is low, stability is poor, and toxic, corrosivity or penetrating odor have one to oral mucosa
Fixed damage, mouth odor can not be eliminated, and also need a large amount of clear water to rinse after disinfection, if certain damage will be caused by accidentally gulping down
Wound.
Application No. is the patents of 201510530816.X to disclose a kind of oral nursing liquid, have group be grouped as: a) account for
The effect of oral nursing liquid composition weight 5-25% composition of plant extracts；B) oral nursing liquid composition weight 0.1- is accounted for
5% the effect of palatability enhancers composition；C) essence of oral nursing liquid composition weight 0.1-3% is accounted for；D) oral care is accounted for
The solubilizer of liquid composition weight 5-35%；E) moisturizer of oral nursing liquid composition weight 5-40% is accounted for；F) oral cavity shield is accounted for
Manage the ethyl alcohol of liquid composition weight 1-10%.
Application No. is the patents of 201711004496.X to disclose a kind of oral cavity shield of oral mucositis caused by Prophylactic chemotherapy
Liquid is managed, the oral nursing liquid raw material of oral mucositis caused by the Prophylactic chemotherapy includes following components by weight: pure water 50-80
Part, 6-10 parts of serissa serissoides, 5-8 parts of the fruit of glossy privet, 8-15 parts of wight fig leaf, 6-10 parts of Radix Rehmanniae, 6-10 parts of radix scrophulariae, Radix Ophiopogonis 8-15 part, sand
Ginseng 6-10 parts, 1.0-2.0 parts of edible essence, sweetener 2.0-3.0 wind part, 5-8 parts of watermelon creme, 7-10 parts of Dobell's solution,
Middle liquid medicine 10-15 parts and antibacterial agent 0.1-0.8 parts compositions.
Application No. is 201711431790.9 patents to disclose a kind of antibacterial reparation hemostasis oral cavity care cream liquid, by weight
Measuring number includes following components: 0.5~2 part of Irish moss；1.0~3.0 parts of sodium lauroyl sarcosine；28~40 parts of moisturizer；Sweet tea
0.2~0.5 part of taste agent；0.3~0.7 part of thickener；30~50 parts of rubbing agent；10~25 parts of deionized water；Houttuynia extract 1
~5 parts；3~6 parts of Merremia boisiana extract；The rubbing agent is Herba Euphorbiae Humifusae powder.
Application No. is 201410803323.4 patents to disclose a kind of oral nursing liquid, by the component system of following weight ratio
It is standby to form: Notogineng Extract 0.5%~2.5%, radix paeoniae alba extraction 0.5%~2.5%, capejasmine extract 0.5%~2.5%,
Haw thorn extract 0.5%~2.5%, glycine betaine 0.05%~0.5%, sodium bicarbonate 0.1%~1%, salt 3%~5%, dimension
Raw element C0.1%~0.4%, cream jasmin france 1%~2% and excess water.
Summary of the invention
The invention mainly solves the technical problem of providing tooth-implanting Chinese medicine nursing liquid, preparation method and plant on tooth
Using.
The present invention is to be achieved through the following technical solutions:
The preparation method of one tooth-implanting Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, mixed, fermented, extracted,
Obtain plant extraction liquid；
(2) plant extraction liquid, corrigent, hydroxypropyl-β-cyclodextrin super molecule inclusion compound, glycerol is taken to be added to the water mixing equal
It is even to get.
Further, the preparation method of tooth-implanting Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, it then will be smashed
Honeysuckle, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1 in mass ratio:
(0.5-1): (1-2): (0.5-1): (0.5-1) is mixed to get material of vegetable origin；Material of vegetable origin will be added in material of vegetable origin
It is 30-33 DEG C of sealing and fermenting 4-8d that the lactobacillus plantarum bacterium solution of weight 0.01-0.2%, which is uniformly mixed in temperature, is then added and plants
It is 34-36 DEG C of sealing and fermenting 3-5d that the lactobacillus acidophilus bacterium solution of object raw-material weight 0.005-0.01%, which is uniformly mixed in temperature,
Obtain fermentation mixture；The water that 10-20 times of mixture weight of fermentation is added to fermentation mixture is mentioned in temperature for 80-90 DEG C of ultrasound
30-60min is taken, using 200-800 mesh filter-cloth filtering, obtains filtrate and filter residue；By the 65- of 10-20 times of filter residue and filter residue weight
It is 80-90 DEG C of refluxing extraction 1-3h that 75wt% ethanol water, which is blended in temperature, and centrifuge separation abandons precipitating, obtains refluxing extraction
Liquid；Filtrate and reflux extracting liquid are merged, the 10-20% of original volume is concentrated in vacuo to, obtains plant extraction liquid；
(2) plant extraction liquid 1-10 parts by weight, corrigent 0.05-0.5 parts by weight, hydroxypropyl-β-cyclodextrin supermolecule are taken
Inclusion compound 0.5-2.5 parts by weight, glycerol 2-6 parts by weight be added water 90-100 parts by weight in be uniformly mixed to get.
Further, the preparation method of tooth-implanting Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, it then will be smashed
Honeysuckle, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1 in mass ratio:
(0.5-1): (1-2): (0.5-1): (0.5-1) is mixed to get material of vegetable origin；Material of vegetable origin will be added in material of vegetable origin
It is 35-45 DEG C of enzymatic hydrolysis 5-10h that the enzyme solution of weight 10-25%, which is uniformly mixed in temperature, adds material of vegetable origin weight 0.01-
It is 30-33 DEG C of sealing and fermenting 4-8d that 0.2% lactobacillus plantarum bacterium solution, which is uniformly mixed in temperature, and material of vegetable origin weight is then added
It is 34-36 DEG C of sealing and fermenting 3-5d that the lactobacillus acidophilus bacterium solution of amount 0.005-0.01%, which is uniformly mixed in temperature, and it is mixed to obtain fermentation
Close material；To fermentation mixture be added fermentation 10-20 times of mixture weight water temperature be 80-90 DEG C of ultrasonic extraction 30-
60min obtains filtrate and filter residue using 200-800 mesh filter-cloth filtering；By the 65-75wt% of 10-20 times of filter residue and filter residue weight
It is 80-90 DEG C of refluxing extraction 1-3h that ethanol water, which is blended in temperature, and centrifuge separation abandons precipitating, obtains reflux extracting liquid；It will filter
Liquid and reflux extracting liquid merge, and are concentrated in vacuo to the 10-20% of original volume, obtain plant extraction liquid；
(2) plant extraction liquid 1-10 parts by weight, corrigent 0.05-0.5 parts by weight, hydroxypropyl-β-cyclodextrin supermolecule are taken
Inclusion compound 0.5-2.5 parts by weight, glycerol 2-6 parts by weight be added water 90-100 parts by weight in be uniformly mixed to get.
Honeysuckle also known as honeysuckle (scientific name: Lonicera japonica)." honeysuckle " one comes from Compendium of Material Medica, by
Just open in honeysuckle flowers as white, after switch to yellow, hence obtain one's name honeysuckle.Medicinal material honeysuckle is Caprifoliaceae woodbine honeysuckle
And congener dry flower or with the flower just opened.Honeysuckle is just extensive and famous with its medical value since ancient times.Its function
Effect is mainly clearing heat and detoxicating, cures mainly warm disease heating, toxic-heat and blood stasis, ulcer serious case of furuncle etc..Modern study proves that honeysuckle contains green original
The pharmacological components such as acid, cyanidenon glycosides, to the various pathogens such as hemolytic streptococcus, Staphylococcus aureus and the upper respiratory tract
Infective virus etc. has stronger restraint, in addition can also strengthen immunity, Robust speaker feature, protect liver, antitumor, anti-inflammatory, it is antipyretic,
Stop blooding (blood coagulation), inhibit intestinal absorption cholesterol etc., clinical application is very extensive, can exhale with other medicines compatibility for treating
Inhale more than 40 illnesss such as road infection, bacillary dysentery, acute urinary, hypertension.
Green tea (Green Tea) is one of the main teas of China, refers to the young leaves or bud for taking tea tree, not fermented,
The drink made through techniques such as water-removing, shaping, drying.The color of its manufactured goods and millet paste after brewing it is more save it is fresh
The green style of tealeaves.Often drink green tea can give protection against cancer, lipid-loweringing and weight-reducing, also can reduce its nicotine injury being subject to smoker.
Green tea is not fermented manufactured tea, remains the natural materials of fresh leaf, tea polyphenols, catechin, chlorophyll, the coffee contained
Alkali, amino acid, vitamins and other nutritious components are also more.These natural nutrition compositions in green tea to anti-aging, anti-cancer, anticancer,
Sterilization, anti-inflammatory etc. have special-effect, are less than other teas.Green tea is to be suitable for And Development of Tea Shoot as raw material, finished,
The tealeaves made of typical process process such as rub, dry.Its dry tea color and millet paste after brewing, tea residue using green as homophony,
Therefore named green tea.Green tea is will to pick the fresh leaf come first through high-temperature fixation, has killed various oxidizing ferment, maintains tealeaves green, so
By rubbing, drying and be made, clear soup greenery are the common features of green tea quality.The range of domestic product green tea is extremely wide,
Henan, Guizhou, Jiangxi, Anhui, Zhejiang, Jiangsu, Sichuan, Shaanxi, Hunan, Hubei, Guangxi, Fujian are that the green tea main product in China saves
Part.
Granatum, Chinese medicine name.For the drying pericarp of Punicaceae plant pomegranate Punica granatum L..China north and south is all
There is cultivation, it is more with Jiangsu, Henan and other places.With relieving diarrhea with astringents, the effect of hemostasis, expelling parasite.It is usually used in chronic diarrhea, protracted dysentery, hematochezia,
Rectal prolapse, metrorrhagia and metrostaxis, leukorrhagia, abdominal pain due to enterositosis.Granatum decoction is in vitro to the 4 clock shigella dysenteriaes such as in will he, Amur, Fu Shi and Song
There is antibacterial action, most strong to the effect of will he, Amur, Fu Shi take second place, and act on bacterium sonnei poor.Compare in 400 kinds
Medicine is for sterilizing power in the test tube of typhoid bacillus, comma bacillus, staphylococcus etc., it was demonstrated that the effect of granatum inhibition typhoid bacillus
It is most strong.In addition, experiment in vitro proves that thin mattresses a variety of to tubercle bacillus, Escherichia coli, proteus, Pseudomonas aeruginosa etc. have inhibition
Effect.Granatum decocting liquid gavages or the intraperitoneal injection of granatum alcohol extracting thing, to inoculation Pseudomonas aeruginosa model after mouse scald
In vivo studies, no obvious protective function.Granatum flooding agent (1:4) is in vitro to Jin Shi trichophyta, proper alignment hair tinea mattress etc.
A variety of dermatophytes have the inhibiting effect for the degree of paying no attention to.The above antibacterial action, may be related with contained matter of largely mixing.
Schisandra chinensis (scientific name: Schisandra chinensis (Turcz.) Baill) is magnoliaceae schisandra or China
The dry mature fruit of middle Schisandra chinensis Schisandra sphenanthera Rehd.et Wils..The former practises title " Chinese Magnoliavine
Son ", the latter, which practises, claims " kadsura longepedunculata ".It picks, dry or is dried after steaming when the fruit matures in the fall, remove carpopodium and impurity.Tang etc.
" Tang materia medica " carries " five tastes skin and flesh sweet acid works hard in core, there is saline taste ", therefore has the name of Schisandra chinensis.Schisandra chinensis is divided into south, north two
Kind.Ancient medical book Cheng Ta Chinese magnoliavine, Chinese magnoliavine, meeting and, be listed in Sheng Nong's herbal classic top grade Chinese medicine earliest, can strengthening by means of tonics power, medicinal valence
Be worth it is high, the benefits of keeping fit and healthy, with Qiongzhen Ganoderma Lucidum share treatment insomnia.
Aloe (scientific name: Aloe vera) Aloe, is Liliaceae perennial evergreen herbaceous plant, and leafage is raw, big and fertile
Thickness in seat shape or is born in stem top, and there is sharp tooth thorn at the normal lanceolar of leaf or the short width of leaf, edge.Inflorescence is umbrella shape, total shape, spike, circle
Taper etc., color is in red, yellow or tool redness of the skin or complexion spot, six, petal, six pieces of gynoecium.The more joints of perianth base portion are at tubular.Pharmacological action:
Bactericidal effect, anti-inflammatory effect moisten beautification function, the effect of letting out under stomach invigorating, and heart tonifying promoting blood circulation acts on, and immune and palingenesis is immunized
With antitumor action, detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function.
The green tea is Longjing tea or Pilochun (a green tea) or Xinyang Maojian Tea.
The enzyme solution is by pectase 0.2-0.4 parts by weight, cellulase 0.2-0.4 parts by weight, amylase 0.2-0.4 weight
Part, water 90-99 parts by weight composition.
The corrigent is xylitol or sorbierite.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is that the hydroxypropyl-β-cyclodextrin of butyl p-hydroxybenzoate is super
Molecular clathrate, at least one of hydroxypropyl-β-cyclodextrin super molecule inclusion compound of Para Hydroxy Benzoic Acid propyl ester.Further
Ground, the hydroxypropyl-β-cyclodextrin super molecule inclusion compound are the hydroxypropyl-β-cyclodextrin oversubscription attached bag of butyl p-hydroxybenzoate
Close object, be in mass ratio 1:(2-3 to the hydroxypropyl-β-cyclodextrin super molecule inclusion compound of Para Hydroxy Benzoic Acid propyl ester) composition.
The lactobacillus plantarum bacterium solution is added in the water of 12-22 times of lactobacillus plantarum weight by lactobacillus plantarum and is uniformly mixed
To obtain the final product.
The lactobacillus acidophilus bacterium solution is added in the water of 12-22 times of lactobacillus acidophilus weight by lactobacillus acidophilus and is uniformly mixed
To obtain the final product.
The present invention also provides tooth-implanting Chinese medicine nursing liquid, by the preparation method system of above-mentioned plant tooth Chinese medicine nursing liquid
It is standby to form.
The present invention also provides above-mentioned plant tooth Chinese medicine nursing liquid to plant the application on tooth.Concrete application method is to plant
It is gargled per daily plant tooth with Chinese medicine nursing liquid after tooth, three times a day.
The beneficial effects of the present invention are:
Honeysuckle of the present invention, aloe, green tea, granatum, Schisandra chinensis have the function of sterilization, anti-inflammatory；
The present invention plants tooth Chinese medicine nursing liquid, and safe and non-stimulating, ingredient is natural, can have effective fresh breath, sterilize, disappears
Scorching, detumescence, the oral care after can be used for planting tooth, the oral health for improving people are horizontal.
Specific embodiment
As follows using disclosure: lactobacillus plantarum is provided by Shaanxi Teng Mai biotechnology Co., Ltd, active bacteria
Content is 10,000,000,000 cfu/ grams.Lactobacillus acidophilus is provided by Shaanxi Teng Mai biotechnology Co., Ltd, and active bacterial content is
10000000000 cfu/ grams.Aloe is the fresh aloe barbadensis Miller blade that quality product aloe barbadensis Miller garden spot in Longgang District of Shenzhen City provides.It is green
Tea is bright preceding one grade of Longjing tea that Hangzhou old farmer Ecological Tea Co., Ltd provides, and source area is Hangzhou.Honeysuckle is Bozhou City
The health pharmaceutcal corporation, Ltd of good fortune provides, and source area is Henan.Granatum provides for Bozhou City often rich medicine company sale Co., Ltd, former
The place of production is Anhui.Schisandra chinensis sells Co., Ltd for the prosperous health hall medicine company of Bozhou City and provides, and source area is Liaoning.P-hydroxybenzoic acid
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound of butyl ester is according to embodiment in the Chinese patent application No. is 201410300799.6
The preparation of method shown in 2.To the hydroxypropyl-β-cyclodextrin super molecule inclusion compound of Para Hydroxy Benzoic Acid propyl ester according to application No. is
201410298445.2 Chinese patent in the preparation of method shown in embodiment 2.Pectase is the credit of the Jiangsu one hundred limited public affairs of biotechnology
Department provides, food-grade, and enzyme activity is 50,000 U/g.Cellulase provides for Zhejiang east into Biotechnology Co., Ltd, food-grade, enzyme
Vigor is 30,000 U/g.Amylase provides for Pangbo Bioengineering Co Ltd, Nanning, food-grade, and enzyme activity is 10,000 U/g.Xylose
Alcohol, No. CAS: 16277-71-7.Glycerol, No. CAS: 56-81-5.
Embodiment 1
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The plant cream of material of vegetable origin weight 0.014% will be added in material of vegetable origin
It is 32 DEG C of sealing and fermenting 6d that bacillus bacterium solution, which is uniformly mixed in temperature, and the acidophilus cream of material of vegetable origin weight 0.008% is then added
It is 35 DEG C of sealing and fermenting 4d that bacillus bacterium solution, which is uniformly mixed in temperature, obtains fermentation mixture；It is mixed that fermentation is added to fermentation mixture
It is 85 DEG C of ultrasonic extraction 40min that the water for expecting 15 times of weight, which is closed, in temperature, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency
Rate is 40kHz, then uses 600 mesh filter-cloth filterings, obtains filtrate and filter residue；By filter residue and 15 times of filter residue weight of 70wt% second
It is 85 DEG C of refluxing extraction 2h that alcohol solution, which is blended in temperature, is then that 9000r/min is centrifugated 20min abandoning precipitating with revolving speed,
Obtain reflux extracting liquid；Merge filtrate and reflux extracting liquid to obtain mixed liquor, by mixed liquor temperature be 60 DEG C, absolute pressure
Be concentrated in vacuo to former mixeding liquid volume for 0.01MPa 15%, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 2
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, the lactobacillus plantarum bacterium solution for adding material of vegetable origin weight 0.014% is uniformly mixed
Temperature is 32 DEG C of sealing and fermenting 6d, and the lactobacillus acidophilus bacterium solution that material of vegetable origin weight 0.008% is then added is uniformly mixed
Temperature is 35 DEG C of sealing and fermenting 4d, obtains fermentation mixture；The water that 15 times of mixture weight of fermentation is added to fermentation mixture exists
Temperature is 85 DEG C of ultrasonic extraction 40min, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 40kHz, is then used
600 mesh filter-cloth filterings, obtain filtrate and filter residue；The 70wt% ethanol water of filter residue and 15 times of filter residue weight is blended in temperature
For 85 DEG C of refluxing extraction 2h, it is then that 9000r/min is centrifugated 20min abandoning precipitating with revolving speed, obtains reflux extracting liquid；It will filter
Liquid and reflux extracting liquid merge to obtain mixed liquor, by mixed liquor temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to
The 15% of former mixeding liquid volume, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 3
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, adds lactobacillus plantarum bacterium solution, the material of vegetable origin of material of vegetable origin weight 0.014%
It is 32 DEG C of sealing and fermenting 6d that the lactobacillus acidophilus bacterium solution of weight 0.008%, which is uniformly mixed in temperature, is then 35 DEG C close in temperature
Seal ferment 4d obtains fermentation mixture；The water that 15 times of mixture weight of fermentation is added to fermentation mixture is 85 DEG C in temperature and surpasses
Sound extracts 40min, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 40kHz, then uses 600 mesh filter cloth mistakes
Filter, obtains filtrate and filter residue；It is 85 DEG C of reflux that filter residue and 15 times of filter residue weight of 70wt% ethanol water, which are blended in temperature,
2h is extracted, is then that 9000r/min is centrifugated 20min abandoning precipitating with revolving speed, obtains reflux extracting liquid；Filtrate and reflux are mentioned
Liquid is taken to merge to obtain mixed liquor, by mixed liquor temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to former mixing liquid
Long-pending 15%, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 4
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, adds lactobacillus plantarum bacterium solution, the material of vegetable origin of material of vegetable origin weight 0.014%
It is 32 DEG C of sealing and fermenting 10d that the lactobacillus acidophilus bacterium solution of weight 0.008%, which is uniformly mixed in temperature, obtains fermentation mixture；To
The water of 15 times of mixture weight of fermentation of fermentation mixture addition is 85 DEG C of ultrasonic extraction 40min in temperature, the ultrasonic extraction
Ultrasonic power is 300W, supersonic frequency 40kHz, then uses 600 mesh filter-cloth filterings, obtains filtrate and filter residue；By filter residue with
It is 85 DEG C of refluxing extraction 2h that 15 times of filter residue weight of 70wt% ethanol water, which is blended in temperature, is then 9000r/ with revolving speed
Min is centrifugated 20min and abandons precipitating, obtains reflux extracting liquid；Merge filtrate and reflux extracting liquid to obtain mixed liquor, will mix
Liquid obtains plant extraction liquid temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to the 15% of former mixeding liquid volume；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 5
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, adds lactobacillus plantarum bacterium solution, the material of vegetable origin of material of vegetable origin weight 0.014%
It is 35 DEG C of sealing and fermenting 10d that the lactobacillus acidophilus bacterium solution of weight 0.008%, which is uniformly mixed in temperature, obtains fermentation mixture；To
The water of 15 times of mixture weight of fermentation of fermentation mixture addition is 85 DEG C of ultrasonic extraction 40min in temperature, the ultrasonic extraction
Ultrasonic power is 300W, supersonic frequency 40kHz, then uses 600 mesh filter-cloth filterings, obtains filtrate and filter residue；By filter residue with
It is 85 DEG C of refluxing extraction 2h that 15 times of filter residue weight of 70wt% ethanol water, which is blended in temperature, is then 9000r/ with revolving speed
Min is centrifugated 20min and abandons precipitating, obtains reflux extracting liquid；Merge filtrate and reflux extracting liquid to obtain mixed liquor, will mix
Liquid obtains plant extraction liquid temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to the 15% of former mixeding liquid volume；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 6
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, the lactobacillus plantarum bacterium solution for adding material of vegetable origin weight 0.014% is uniformly mixed
Temperature is 32 DEG C of sealing and fermenting 6d, and the lactobacillus acidophilus bacterium solution that material of vegetable origin weight 0.008% is then added is uniformly mixed
Temperature is 35 DEG C of sealing and fermenting 4d, obtains fermentation mixture；The water that 30 times of mixture weight of fermentation is added to fermentation mixture exists
Temperature is 85 DEG C of ultrasonic extraction 40min, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 40kHz, is then used
600 mesh filter-cloth filterings, obtain filtrate and filter residue；By filtrate temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to original
The 15% of mixeding liquid volume, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin to Para Hydroxy Benzoic Acid propyl ester
Super molecule inclusion compound.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 7
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, the lactobacillus plantarum bacterium solution for adding material of vegetable origin weight 0.014% is uniformly mixed
Temperature is 32 DEG C of sealing and fermenting 6d, and the lactobacillus acidophilus bacterium solution that material of vegetable origin weight 0.008% is then added is uniformly mixed
Temperature is 35 DEG C of sealing and fermenting 4d, obtains fermentation mixture；The water that 15 times of mixture weight of fermentation is added to fermentation mixture exists
Temperature is 85 DEG C of ultrasonic extraction 40min, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 40kHz, is then used
600 mesh filter-cloth filterings, obtain filtrate and filter residue；The 70wt% ethanol water of filter residue and 15 times of filter residue weight is blended in temperature
For 85 DEG C of refluxing extraction 2h, it is then that 9000r/min is centrifugated 20min abandoning precipitating with revolving speed, obtains reflux extracting liquid；It will filter
Liquid and reflux extracting liquid merge to obtain mixed liquor, by mixed liquor temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to
The 15% of former mixeding liquid volume, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is that the hydroxypropyl-β-cyclodextrin of butyl p-hydroxybenzoate is super
Molecular clathrate.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Embodiment 8
Plant the preparation method of tooth Chinese medicine nursing liquid, comprising the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 10 meshes respectively, then by smashed gold
Honeysuckle flower, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:1 in mass ratio:
1.5:0.6:0.8 is mixed to get material of vegetable origin；The enzyme solution that material of vegetable origin weight 15% is added in material of vegetable origin is mixed
It is uniformly 40 DEG C of enzymatic hydrolysis 6h in temperature, the lactobacillus plantarum bacterium solution for adding material of vegetable origin weight 0.014% is uniformly mixed
Temperature is 32 DEG C of sealing and fermenting 6d, and the lactobacillus acidophilus bacterium solution that material of vegetable origin weight 0.008% is then added is uniformly mixed
Temperature is 35 DEG C of sealing and fermenting 4d, obtains fermentation mixture；The water that 15 times of mixture weight of fermentation is added to fermentation mixture exists
Temperature is 85 DEG C of ultrasonic extraction 40min, and the ultrasonic power of the ultrasonic extraction is 300W, supersonic frequency 40kHz, is then used
600 mesh filter-cloth filterings, obtain filtrate and filter residue；The 70wt% ethanol water of filter residue and 15 times of filter residue weight is blended in temperature
For 85 DEG C of refluxing extraction 2h, it is then that 9000r/min is centrifugated 20min abandoning precipitating with revolving speed, obtains reflux extracting liquid；It will filter
Liquid and reflux extracting liquid merge to obtain mixed liquor, by mixed liquor temperature is 60 DEG C, absolute pressure is that 0.01MPa is concentrated in vacuo to
The 15% of former mixeding liquid volume, obtains plant extraction liquid；
(2) 5 parts by weight of plant extraction liquid, 0.1 parts by weight of corrigent, 1 weight of hydroxypropyl-β-cyclodextrin super molecule inclusion compound are taken
Measure part, 4 parts by weight of glycerol are added in 92 parts by weight of water and are uniformly mixed to get tooth Chinese medicine nursing liquid is planted.
The green tea is Longjing tea.
99 weight of water is added by 0.3 parts by weight of pectase, 0.4 parts by weight of cellulase, 0.3 parts by weight of amylase in the enzyme solution
It is uniformly mixed and obtains in amount part.
The corrigent is xylitol.
The hydroxypropyl-β-cyclodextrin super molecule inclusion compound is surpassed by the hydroxypropyl-β-cyclodextrin of butyl p-hydroxybenzoate
Molecular clathrate is that 1:2 mixing is equal to the hydroxypropyl-β-cyclodextrin super molecule inclusion compound of Para Hydroxy Benzoic Acid propyl ester in mass ratio
It is even to obtain the final product.
The lactobacillus plantarum bacterium solution is added in 19 times of lactobacillus plantarum weight of water by lactobacillus plantarum and is uniformly mixed i.e.
?.
The lactobacillus acidophilus bacterium solution is added in 19 times of lactobacillus acidophilus weight of water by lactobacillus acidophilus and is uniformly mixed i.e.
?.
Test case 1
The DPPH free radical scavenging activity and bacteriostasis property of the plant tooth Chinese medicine nursing liquid of embodiment are tested.Specific knot
Fruit is shown in Table 1.
The measurement of DPPH free radical scavenging activity: DPPH is accurately weighed, the solution of 0.2mmol/L DPPH is configured to, in brown bottle
It is protected from light cryo-conservation.Plant tooth to be measured is diluted to 10mg/mL with Chinese medicine nursing liquid sample with deionized water, obtains sample liquid.It takes
2mL, 10mg/mL sample liquid are uniformly mixed in 2mL, 0.2mmol/L DPPH solution in test tube, is added, and are protected from light standing at room temperature
After 30min, absorbance value at 517nm is measured with ultraviolet specrophotometer UV-2000 (You Nike (Shanghai) limited instrument company),
It is calculated as Ai, while measuring 2mL, 10mg/mL sample liquid and adding 2mL dehydrated alcohol, is protected from light after standing 30min at room temperature, with ultraviolet point
Light photometer UV-2000 (You Nike (Shanghai) limited instrument company) measurement absorbance value at 517nm, is calculated as Aj, and
2mL, 0.2mmol/L DPPH solution add 2mL distilled water to stand, and with ultraviolet specrophotometer UV-2000, (You Nike (Shanghai) has
Limit instrument company) measurement absorbance value at 517nm, it is calculated as Ac.The clearance rate of DPPH free radical is calculated as follows in sample: clear
Except rate=[1- (Ai-Aj)/Ac] × 100%.
Bacteriostasis property: after taking staphylococcus aureus ATCC6538 tryptone brine, then phosphate is used
Buffer salt (PBS) is diluted to 5 × 104cfu/mL.According to version " disinfection technology standard " in 2002, takes and plant tooth Chinese medicine nursing liquid
5mL is placed in sterilizing test tubes, is separately added into the above-mentioned 100 μ L of staphylococcus aureus bacteria suspension prepared, is mixed, is applied to 2
It draws in the test tube of 0.5mL bacterium medicine mixed liquor addition PBS solution containing 4.5mL and mixes when minute, after making appropriate dilute, inhale respectively
Take 1.0mL incline ware do viable bacteria bacterium colony counting.Test 3 times is repeated under conditions of 20 ± 1 DEG C.Staphylococcus aureus bacteriostasis rate
It is golden yellow after staphylococcus aureus quantity/addition plant tooth Chinese medicine nursing liquid 2min before (%)=addition plant tooth Chinese medicine nursing liquid
Color staphylococcus quantity × 100.
Table 1:DPPH free radical scavenging activity and antibacterial test result table
Test case 2
The plant tooth of embodiment is tested with Chinese medicine nursing liquid antiphlogistic effects.Concrete outcome is shown in Table 2.
Experimental animal: Kunming mouse, 18~22g of weight, half male and half female are purchased from Nantong University's experimental animal center.
Experimental condition: single cage is fed, free water, and 22 DEG C of temperature, humidity 60%, illumination appropriateness, ventilation.
It is random to be grouped after Kunming mouse adaptable fed 3 days, every group 10.
Test group: 1mL is smeared in the left ear of mouse daily and plants tooth Chinese medicine nursing liquid, after smearing 7 days, in the left ear of mouse
0.03mL caused by dimethylbenzene xylene inflammation is smeared, continues to smear 1mL plant tooth with Chinese medicine nursing liquid 1 day in the left ear of mouse；Then neck is taken off to put to death
Mouse disposably sweeps away the left auricle and auris dextra piece of mouse with the punching pin of diameter 8mm along auricle edge, keeps the position of two ears punching
It is consistent, weighs, using the weight difference of left and right ear piece as swelling.
The anti-inflammatory effect of conditioning liquid is evaluated using swelling inhibiting rate, wherein the calculation formula of swelling inhibiting rate are as follows: swelling suppression
Rate (%) processed=(control group swelling-test group swelling)/control group swelling × 100%.It is averaged.
Table 2: antiphlogistic effects test test table
Claims (10)
1. the tooth-implanting preparation method of Chinese medicine nursing liquid, which comprises the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, mixed, fermented, extract, obtain
Plant extraction liquid；
(2) plant extraction liquid, corrigent, hydroxypropyl-β-cyclodextrin super molecule inclusion compound, glycerol is taken to be added to the water uniformly mixed,
To obtain the final product.
2. the tooth-implanting preparation method of Chinese medicine nursing liquid, which comprises the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, then by smashed gold and silver
Colored, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:(0.5- in mass ratio
1): (1-2): (0.5-1): (0.5-1) is mixed to get material of vegetable origin；Material of vegetable origin weight will be added in material of vegetable origin
It is 30-33 DEG C of sealing and fermenting 4-8d that the lactobacillus plantarum bacterium solution of 0.01-0.2%, which is uniformly mixed in temperature, and it is former that plant is then added
It is 34-36 DEG C of sealing and fermenting 3-5d that the lactobacillus acidophilus bacterium solution of material weight 0.005-0.01%, which is uniformly mixed in temperature, is obtained
Ferment mixture；To fermentation mixture be added fermentation 10-20 times of mixture weight water temperature be 80-90 DEG C of ultrasonic extraction
30-60min obtains filtrate and filter residue using 200-800 mesh filter-cloth filtering；By the 65- of 10-20 times of filter residue and filter residue weight
It is 80-90 DEG C of refluxing extraction 1-3h that 75wt% ethanol water, which is blended in temperature, and centrifuge separation abandons precipitating, obtains refluxing extraction
Liquid；Filtrate and reflux extracting liquid are merged, the 10-20% of original volume is concentrated in vacuo to, obtains plant extraction liquid；
(2) plant extraction liquid 1-10 parts by weight, corrigent 0.05-0.5 parts by weight, hydroxypropyl-β-cyclodextrin supermolecule inclusion are taken
Object 0.5-2.5 parts by weight, glycerol 2-6 parts by weight be added water 90-100 parts by weight in be uniformly mixed to get.
3. the tooth-implanting preparation method of Chinese medicine nursing liquid, which comprises the following steps:
(1) honeysuckle, aloe, green tea, granatum, Schisandra chinensis be crushed into 5-50 mesh respectively, then by smashed gold and silver
Colored, smashed aloe, smashed green tea, smashed granatum, smashed Schisandra chinensis are 1:(0.5- in mass ratio
1): (1-2): (0.5-1): (0.5-1) is mixed to get material of vegetable origin；Material of vegetable origin weight will be added in material of vegetable origin
It is 35-45 DEG C of enzymatic hydrolysis 5-10h that the enzyme solution of 10-25%, which is uniformly mixed in temperature, adds material of vegetable origin weight 0.01-0.2%
Lactobacillus plantarum bacterium solution be uniformly mixed temperature be 30-33 DEG C of sealings and fermenting 4-8d, then addition material of vegetable origin weight
It is 34-36 DEG C of sealing and fermenting 3-5d that the lactobacillus acidophilus bacterium solution of 0.005-0.01%, which is uniformly mixed in temperature, obtains fermentation mixing
Material；To fermentation mixture be added fermentation 10-20 times of mixture weight water temperature be 80-90 DEG C of ultrasonic extraction 30-60min,
Using 200-800 mesh filter-cloth filtering, filtrate and filter residue are obtained；By the 65-75wt% ethanol water of 10-20 times of filter residue and filter residue weight
It is 80-90 DEG C of refluxing extraction 1-3h that solution, which is blended in temperature, and centrifuge separation abandons precipitating, obtains reflux extracting liquid；By filtrate and return
It flows extracting solution to merge, is concentrated in vacuo to the 10-20% of original volume, obtains plant extraction liquid；
(2) plant extraction liquid 1-10 parts by weight, corrigent 0.05-0.5 parts by weight, hydroxypropyl-β-cyclodextrin supermolecule inclusion are taken
Object 0.5-2.5 parts by weight, glycerol 2-6 parts by weight be added water 90-100 parts by weight in be uniformly mixed to get.
4. as claimed in claim 3 plant tooth Chinese medicine nursing liquid preparation method, which is characterized in that the green tea be Longjing tea or
Pilochun (a green tea) or Xinyang Maojian Tea.
5. planting the preparation method of tooth Chinese medicine nursing liquid as claimed in claim 3, which is characterized in that the enzyme solution is by pectase
0.2-0.4 parts by weight, cellulase 0.2-0.4 parts by weight, amylase 0.2-0.4 parts by weight, water 90-99 parts by weight composition.
6. planting the preparation method of tooth Chinese medicine nursing liquid as claimed in claim 3, which is characterized in that the corrigent is xylitol
Or sorbierite.
7. planting the preparation method of tooth Chinese medicine nursing liquid as claimed in claim 3, which is characterized in that the hydroxy propyl-Beta-ring paste
Smart super molecule inclusion compound is the hydroxypropyl-β-cyclodextrin super molecule inclusion compound of butyl p-hydroxybenzoate, to Para Hydroxy Benzoic Acid
At least one of hydroxypropyl-β-cyclodextrin super molecule inclusion compound of propyl ester.
8. planting the preparation method of tooth Chinese medicine nursing liquid as claimed in claim 3, which is characterized in that the lactobacillus plantarum bacterium solution
It is added in the water of 12-22 times of lactobacillus plantarum weight and is uniformly mixed by lactobacillus plantarum to obtain the final product；The lactobacillus acidophilus bacterium solution by
Lactobacillus acidophilus is added in the water of 12-22 times of lactobacillus acidophilus weight and is uniformly mixed to obtain the final product.
9. tooth-implanting Chinese medicine nursing liquid, which is characterized in that protected using plant tooth described in any one of claim 1-8 with Chinese medicine
The preparation method of reason liquid is prepared.
The application on tooth is being planted with Chinese medicine nursing liquid 10. planting tooth as claimed in claim 9.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910456303.7A CN110115737A (en) | 2019-05-29 | 2019-05-29 | Plant the application on tooth Chinese medicine nursing liquid, preparation method and plant tooth |
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ID=67523544
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190513A (en) * | 2020-11-09 | 2021-01-08 | 上海应用技术大学 | Pomegranate peel and schisandra chinensis fermentation stock solution as well as preparation method and application thereof |
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| CN102273685A (en) * | 2011-06-16 | 2011-12-14 | 闵祥梅 | Pomegranate health beverage for both gargling and eating and manufacturing method thereof |
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2019
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| CN102273685A (en) * | 2011-06-16 | 2011-12-14 | 闵祥梅 | Pomegranate health beverage for both gargling and eating and manufacturing method thereof |
| CN107648136A (en) * | 2017-09-28 | 2018-02-02 | 杨功平 | Nurse the mouthwash in oral cavity and preparation method thereof |
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| 李钊等: "复方五味子含漱液治疗复发性口腔溃疡的近期疗效观察", 《中国实验方剂学杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190513A (en) * | 2020-11-09 | 2021-01-08 | 上海应用技术大学 | Pomegranate peel and schisandra chinensis fermentation stock solution as well as preparation method and application thereof |
| CN112190513B (en) * | 2020-11-09 | 2023-07-11 | 上海应用技术大学 | Pomegranate rind and schisandra chinensis fermentation stock solution and preparation method and application thereof |
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Application publication date: 20190813 |