CN105311131A - Traditional Chinese medicine composition with antibacterial and anti-inflammation functions and preparation method and application of traditional Chinese medicine composition with antibacterial and anti-inflammation functions - Google Patents
Traditional Chinese medicine composition with antibacterial and anti-inflammation functions and preparation method and application of traditional Chinese medicine composition with antibacterial and anti-inflammation functions Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with antibacterial and anti-inflammation functions. The traditional Chinese medicine composition is prepared from, by weight, 35-50 parts of radix paeoniae alba, 10-22 parts of radix glycyrrhizae, 5-10 parts of herba rabdosiae rubescentis and 20-35 parts of folium microcotis. A preparation of the traditional Chinese medicine composition with the antibacterial and anti-inflammation functions includes: mixing and grinding the components, heating and extracting with distilled water, performing vacuum filtration to obtain a medicinal extract solution, using AB-8 macroporous adsorption resin for separating and purifying the medicinal extract solution to obtain medicinal purified solution, and subjecting eluent to activated carbon decolorization, condensation and spray drying to obtain the traditional Chinese medicine composition with the antibacterial and anti-inflammation functions. The traditional Chinese medicine composition has excellent antibacterial and anti-inflammation functions.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with anti-inflammation and its preparation method and application.
Background technology
Dental care product is clean and health product indispensable in people's daily life, this series products is of a great variety, comprise toothpaste, dentifrice, collutory, chewing gum, oral spray etc., be mainly used in keeping oral cavity and cleaning of teeth, promotion breath freshening, nurse gingiva, safeguard oral cavity good environment etc.Composition in existing dental care product is many containing the Western medicine such as antibiotic, hormone goods, although effect is rapid, can not fundamentally treat, and with high costs, is very easy to bring the adverse effects such as secondary dysbacteriosis.And traditional Chinese medical herbal treatment method is more and more subject to doctor, the attention of patient and favor.
Summary of the invention
The object of the invention is to overcome prior art defect, a kind of Chinese medicine composition with anti-inflammation is provided.
Another object of the present invention is to provide the above-mentioned preparation method with the Chinese medicine composition of anti-inflammation.
Another object of the present invention is the application providing above-mentioned Chinese medicine composition.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with anti-inflammation, its raw material is made up of following component: the Radix Paeoniae Alba 35 ~ 50 weight portion, Radix Glycyrrhizae 10 ~ 22 weight portion, Rabdosia rubescens 5 ~ 10 weight portion and Folium Microcoris paniculatae 20 ~ 35 weight portion, its preparation method comprises: use distilled water heating extraction by after above-mentioned each component co-grinding, filtration under diminished pressure obtains herbal extract, this herbal extract is obtained medical material refined solution through the separation and purification of AB-8 macroporous adsorbent resin, by this eluent activated carbon decolorizing, concentrated and spraying dry, there is described in obtaining the Chinese medicine composition of anti-inflammation.
In a preferred embodiment of the invention, its raw material is made up of following component: the Radix Paeoniae Alba 45 ~ 48 weight portion, Radix Glycyrrhizae 15 ~ 20 weight portion, Rabdosia rubescens 6 ~ 9 weight portion and Folium Microcoris paniculatae 25 ~ 30 weight portion.
Its raw material preferred is made up of following component further: the Radix Paeoniae Alba 45 weight portion, Radix Glycyrrhizae 18 weight portion, Rabdosia rubescens 8 weight portion and Folium Microcoris paniculatae 27 weight portion.
An above-mentioned preparation method with the Chinese medicine composition of anti-inflammation, comprises the steps:
(1) each component is taken by weight;
(2) by after above-mentioned each component co-grinding, cross 30 ~ 50 mesh sieves, with the distilled water heating extraction 2 ~ 3 times of 6 ~ 8 times of volumes, each time of extracting is 1.5 ~ 2.5h, each extract after all carry out filtration under diminished pressure, remerge filtrate, obtain herbal extract;
(3) after AB-8 macroporous adsorbent resin first being used 95 ~ 100% soak with ethanol 12 ~ 14h, then mix not in white casse to ethanol elution with water with 95 ~ 100% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9 ~ 10, above-mentioned AB-8 macroporous adsorbent resin wet method filled post;
(4) herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6 ~ 7 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.0 ~ 1.5mL/min, 6 ~ 7h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 4 ~ 5 times again, then use 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 ~ 7 times, collect eluent, decompression recycling ethanol;
(5) in the material that step (4) is obtained, add the medical activated carbon of crude drug weight 0.1 ~ 0.15 times, 55 ~ 60 DEG C of insulation decolouring 1 ~ 2h, after medical material refined solution;
(6) carry out spraying dry after suitably being concentrated by above-mentioned medical material refined solution, there is described in obtaining the Chinese medicine composition of anti-inflammation.
In a preferred embodiment of the invention, described step (2) is: after above-mentioned each component co-grinding, cross 30 mesh sieves, with the distilled water heating extraction 2 times of 6 ~ 8 times of volumes, the time of each extraction is 2h, all carry out filtration under diminished pressure after each extraction, remerge filtrate, obtain herbal extract.
In a preferred embodiment of the invention, described step (3) is: after AB-8 macroporous adsorbent resin is first used 95% soak with ethanol 12h, then mix not in white casse to ethanol elution with water with 95% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9, above-mentioned AB-8 macroporous adsorbent resin wet method filled post.
In a preferred embodiment of the invention, described step (4) is: herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6.5 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.0mL/min, 6h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 4 times again, then 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 times are used, collect eluent, decompression recycling ethanol.
In a preferred embodiment of the invention, described step (5) is: the medical activated carbon adding crude drug weight 0.1 times in the material that step (4) is obtained, 60 DEG C of insulation decolouring 1h, after medical material refined solution.
A kind of above-mentioned Chinese medicine composition with anti-inflammation is preparing the application in dental care product.
In a preferred embodiment of the invention, described dental care product is the dosage forms such as cleaning agent for mouth cavity, toothpaste, collutory, teeth consolidating cream, teeth consolidating powder, oral spray.
The invention has the beneficial effects as follows:
1, Chinese medicine composition of the present invention has stronger antiphlogistic antibacterial effect, wherein Radix Glycyrrhizae, is the dry root welding technology of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Contained effective ingredient is triterpene saponin and flavone, has the multiple functions such as antiinflammatory, antibacterial, antiallergic action, analgesia, removing toxic substances; Also inhibitory action is had to oral disease.The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae.Effective ingredient contained by Radix Paeoniae take peoniflorin as the sesquiterpene glycoside material of representative, has the effects such as stronger antiinflammatory, analgesia, antibacterial, antioxidation.Rabdosia rubescens has another name called Rabdosia rubescens, order in June, for Labiatae Rabdosia plant is cracked rice the dry herb of fork, containing Diterpenoids from bulbus such as rubescensine A, anti-inflammation Rabdosia rubescens all has low dose of antibacterial to staphylococcus aureus, Diplococcus pneumoniae, group B streptococcus, heavy dose of bactericidal action, also has stronger anti-inflammatory analgesic action.Folium Microcoris paniculatae, another name Folium Microcoris paniculatae is the dried leaves of Tiliaceae Folium Microcoris paniculatae platymiscium Folium Microcoris paniculatae, containing volume flavones ingredient and Alkaloid, has the effects such as antipyretic, antiinflammatory and blood fat reducing.In this Chinese medicine composition, Radix Paeoniae Alba yin nourishing blood, suppressing the hyperactive liver sun, relieving spasm to stop pain, contained peoniflorin has the effects such as stronger antiinflammatory, antibacterial, antioxidation.Rabdosia rubescens heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, Folium Microcoris paniculatae damp eliminating heat clearing away, Radix Glycyrrhizae then integrates the property of medicine, contained glycyrrhizic acid energy anti-inflammation, and four kinds of medicines share, can strengthening vital QI to eliminate pathogenic factors, and Yin Yang balancing, nurses one's health comprehensively, reaches hemostasis and anti-inflammation, antibacterial, dispels the effects such as halitosis.And having nontoxic, the advantage such as with low cost, is worthy to be popularized.
2, preparation method process of the present invention is simple, and equipment requirements is low, is applicable to suitability for industrialized production.
Detailed description of the invention
Below by way of detailed description of the invention, technical scheme of the present invention is further detailed and is described.
Embodiment 1
(1) each component is taken by weight: the Radix Paeoniae Alba 35 ~ 50 weight portion, Radix Glycyrrhizae 10 ~ 22 weight portion, Rabdosia rubescens 5 ~ 10 weight portion and Folium Microcoris paniculatae 20 ~ 35 weight portion;
(2) by after above-mentioned each component co-grinding, cross 50 mesh sieves, with the distilled water heating extraction 3 times of 68 times of volumes, each time of extracting is 1.5h, each extract after all carry out filtration under diminished pressure, remerge filtrate, obtain herbal extract;
(3) after AB-8 macroporous adsorbent resin first being used 100% soak with ethanol 13h, then mix not in white casse to ethanol elution with water with 100% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9, above-mentioned AB-8 macroporous adsorbent resin wet method filled post;
(4) herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.2mL/min, 6.5h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 5 times again, then use 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 times, collect eluent, decompression recycling ethanol;
(5) in the material that step (4) is obtained, add the medical activated carbon of crude drug weight 0.12 times, 55 DEG C of insulation decolouring 2h, after medical material refined solution;
(6) carry out spraying dry after suitably being concentrated by above-mentioned medical material refined solution, there is described in obtaining the Chinese medicine composition of anti-inflammation.
Embodiment 2
(1) each component is taken by weight: the Radix Paeoniae Alba 45 ~ 48 weight portion, Radix Glycyrrhizae 15 ~ 20 weight portion, Rabdosia rubescens 6 ~ 9 weight portion and Folium Microcoris paniculatae 25 ~ 30 weight portion;
(2) by after above-mentioned each component co-grinding, cross 40 mesh sieves, with the distilled water heating extraction 2 times of 6 times of volumes, each time of extracting is 2.5h, each extract after all carry out filtration under diminished pressure, remerge filtrate, obtain herbal extract;
(3) after AB-8 macroporous adsorbent resin first being used 95% soak with ethanol 4h, then mix not in white casse to ethanol elution with water with 95% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 10, above-mentioned AB-8 macroporous adsorbent resin wet method filled post;
(4) herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 7 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.5mL/min, 7h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 5 times again, then use 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 7 times, collect eluent, decompression recycling ethanol;
(5) in the material that step (4) is obtained, add the medical activated carbon of crude drug weight 0.12 times, 57 DEG C of insulation decolouring 1.5h, after medical material refined solution;
(6) carry out spraying dry after suitably being concentrated by above-mentioned medical material refined solution, there is described in obtaining the Chinese medicine composition of anti-inflammation.
Embodiment 3
(1) each component is taken by weight: the Radix Paeoniae Alba 45 weight portion, Radix Glycyrrhizae 18 weight portion, Rabdosia rubescens 8 weight portion and Folium Microcoris paniculatae 27 weight portion;
(2) by after above-mentioned each component co-grinding, cross 30 mesh sieves, with the distilled water heating extraction 2 times of 6 ~ 8 times of volumes, each time of extracting is 2h, each extract after all carry out filtration under diminished pressure, remerge filtrate, obtain herbal extract.
(3) after AB-8 macroporous adsorbent resin first being used 95% soak with ethanol 12h, then mix not in white casse to ethanol elution with water with 95% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9, above-mentioned AB-8 macroporous adsorbent resin wet method filled post.
(4) herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6.5 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.0mL/min, 6h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 4 times again, then use 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 times, collect eluent, decompression recycling ethanol.
(5) in the material that step (4) is obtained, add the medical activated carbon of crude drug weight 0.1 times, 60 DEG C of insulation decolouring 1h, after medical material refined solution.
(6) carry out spraying dry after suitably being concentrated by above-mentioned medical material refined solution, there is described in obtaining the Chinese medicine composition of anti-inflammation.
Embodiment 4
1, the impact of the Chinese medicine composition xylol induced mice auricle edema of embodiment 3 preparation
The preparation of sample: Chinese medicine composition prepared by Example 3, add 1%CMC-Na solution and a small amount of Tween-20, mixing porphyrize, filters for subsequent use, and obtained large, medium and small dosage group sample, concentration is respectively 0.1g/mL, 0.2g/mL and 0.4g/mL.
Method: get healthy mice 40, ♂, 18-21g, be divided into 4 groups at random, often organizes 10.Be respectively heavy dose of group, middle dosage group, small dose group, blank group (be coated with same volume 1%CMC-Na solution), positive controls (ibuprofen emulsifiable paste).Give mouse right ear coating respectively, large and small dosage group all smears relative medicine thickness of covering all about 2mm; 10min is coated with once, and to 1h, clean left ear with normal saline, absorbent cotton is dried, and 10min rear left ear is coated with dimethylbenzene 0.04mL, and after Yu Zhiyan, 10min, 2h respectively organize again and be the samely coated with relative medicine respectively.Put to death mice after being coated with dimethylbenzene 4h, put to death front normal saline and clean left ear, absorbent cotton is dried; Cut ears, alignment, lays round auricle with 8mm card punch, and weigh with analytical balance rapidly, the difference of ears weight is swelling, and result is as shown in table 1 below.
Table 1 external extract is on the impact (x ± s, n=10) of mice dimethylbenzene ear swelling
Compare with matched group,
*p<0.05,
*p<0.01
The aqueous solution of Chinese medicine composition prepared by result display embodiment 3 significantly can suppress mice dimethylbenzene ear swelling, and Chinese medicine composition prepared by prompting embodiment 3 has good antiinflammatory action.
2, the fungistatic effect of the Chinese medicine composition oral cavity common pathogen of embodiment 3 preparation
Bacterium liquid and culture medium prepare: get Streptococcus mutans, gold-coloured staphylococci, the dilution of Candida albicans (being provided by my school microorganism teaching and research room) physiological saline solution be mixed with test organisms suspension, make bacteria containing amount be 1 × 10
8cfu/ml.Getting the mixing of each bacteria suspension 1ml, calf serum 0.2ml and 15ml fusing Beef soup culture medium respectively makes containing the dull and stereotyped condensation of bacterium stand-by.Candida albicans makes dull and stereotyped by husky fort culture medium.
Prepared by sample solution: Chinese medicine composition prepared by Example 3 is appropriate, adds appropriate distilled water, makes it into the solution that concentration is 0.2g/ml, subpackage sterilizing, store for subsequent use.Required concentration is diluted to before use with sodium chloride injection.
Bacteriostatic test: get qualitative filter paper, is made into the disk of 6mm diameter, through pressuresteam sterilization.Again the dilution of sample solution medical saline is mixed with variable concentrations, collutory safe with mouth does parallel comparative test containing (1200mg/L chlorhexidine acetate) simultaneously.Filter paper is placed with prepare containing bacterium culture medium surface, between the scraps of paper and the scraps of paper and plate edge distance 15mm, each flat board is placed with 4 ~ 6 filter papers.Accurately get 10 dilution Pericarpium Citri tangerinae extracting solution 10 μ l, add successively on each filter paper.Cultivate 24h under flat board after dosing being placed in 37 DEG C of conditions, Candida albicans is dull and stereotyped cultivates 48h in 37 DEG C, accurately measures inhibition zone diameter.
The bacteriostasis result of table 2 extract
Note :-without bacterial restrain; Positive controls is the safe collutory of mouth.
With to oral cavity principal causative causal organism for object of study, carry out fungistatic effect detection with disk diffusion method.Result proves, Chinese medicine composition extract prepared by embodiment 3 has good Antibacteria effect.
As from the foregoing, Chinese medicine composition of the present invention can be applied to be prepared in dental care product, and described dental care product is the dosage forms such as cleaning agent for mouth cavity, toothpaste, collutory, teeth consolidating cream, teeth consolidating powder, oral spray.
The above, be only preferred embodiment of the present invention, therefore can not limit scope of the invention process according to this, the equivalence change namely done according to the scope of the claims of the present invention and description with modify, all should still belong in scope that the present invention contains.
Claims (10)
1. one kind has the Chinese medicine composition of anti-inflammation, it is characterized in that: its raw material is made up of following component: the Radix Paeoniae Alba 35 ~ 50 weight portion, Radix Glycyrrhizae 10 ~ 22 weight portion, Rabdosia rubescens 5 ~ 10 weight portion and Folium Microcoris paniculatae 20 ~ 35 weight portion, its preparation method comprises: use distilled water heating extraction by after above-mentioned each component co-grinding, filtration under diminished pressure obtains herbal extract, this herbal extract is obtained medical material refined solution through the separation and purification of AB-8 macroporous adsorbent resin, by this eluent activated carbon decolorizing, concentrated and spraying dry, there is described in obtaining the Chinese medicine composition of anti-inflammation.
2. a kind of Chinese medicine composition with anti-inflammation as claimed in claim 1, is characterized in that: its raw material is made up of following component: the Radix Paeoniae Alba 45 ~ 48 weight portion, Radix Glycyrrhizae 15 ~ 20 weight portion, Rabdosia rubescens 6 ~ 9 weight portion and Folium Microcoris paniculatae 25 ~ 30 weight portion.
3. a kind of Chinese medicine composition with anti-inflammation as claimed in claim 2, is characterized in that: its raw material is made up of following component: the Radix Paeoniae Alba 45 weight portion, Radix Glycyrrhizae 18 weight portion, Rabdosia rubescens 8 weight portion and Folium Microcoris paniculatae 27 weight portion.
4. the preparation method with the Chinese medicine composition of anti-inflammation in claims 1 to 3 described in arbitrary claim, is characterized in that: comprise the steps:
(1) each component is taken by weight;
(2) by after above-mentioned each component co-grinding, cross 30 ~ 50 mesh sieves, with the distilled water heating extraction 2 ~ 3 times of 6 ~ 8 times of volumes, each time of extracting is 1.5 ~ 2.5h, each extract after all carry out filtration under diminished pressure, remerge filtrate, obtain herbal extract;
(3) after AB-8 macroporous adsorbent resin first being used 95 ~ 100% soak with ethanol 12 ~ 14h, then mix not in white casse to ethanol elution with water with 95 ~ 100% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9 ~ 10, above-mentioned AB-8 macroporous adsorbent resin wet method filled post;
(4) herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6 ~ 7 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.0 ~ 1.5mL/min, 6 ~ 7h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 4 ~ 5 times again, then use 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 ~ 7 times, collect eluent, decompression recycling ethanol;
(5) in the material that step (4) is obtained, add the medical activated carbon of crude drug weight 0.1 ~ 0.15 times, 55 ~ 60 DEG C of insulation decolouring 1 ~ 2h, after medical material refined solution;
(6) carry out spraying dry after suitably being concentrated by above-mentioned medical material refined solution, there is described in obtaining the Chinese medicine composition of anti-inflammation.
5. preparation method as claimed in claim 4, it is characterized in that: described step (2) is: after above-mentioned each component co-grinding, cross 30 mesh sieves, with the distilled water heating extraction 2 times of 6 ~ 8 times of volumes, the time of each extraction is 2h, all carry out filtration under diminished pressure after each extraction, remerge filtrate, obtain herbal extract.
6. preparation method as claimed in claim 4, it is characterized in that: described step (3) is: after AB-8 macroporous adsorbent resin is first used 95% soak with ethanol 12h, then mix not in white casse to ethanol elution with water with 95% ethanol purge, be washed till without alcohol taste with distilled water again, then in resin column internal diameter and the ratio of post height than 1: 9, above-mentioned AB-8 macroporous adsorbent resin wet method filled post.
7. preparation method as claimed in claim 4, it is characterized in that: described step (4) is: herbal extract prepared by step (2) is slowly splined on resin column prepared by step (3), applied sample amount is 6.5 times by crude drug weighing scale AB-8 macroporous adsorbent resin weight, loading flow velocity is 1.0mL/min, 6h is left standstill after completion of the sample, use the pure water impurity of AB-8 macroporous adsorbent resin weight 4 times again, then 70 ~ 90% ethanol elutions of AB-8 macroporous adsorbent resin weight 6 times are used, collect eluent, decompression recycling ethanol.
8. preparation method as claimed in claim 4, is characterized in that: described step (5) is: the medical activated carbon adding crude drug weight 0.1 times in the material that step (4) is obtained, 60 DEG C of insulation decolouring 1h, after medical material refined solution.
9. the Chinese medicine composition with anti-inflammation in a claims 1 to 3 described in arbitrary claim is preparing the application in dental care product.
10. apply as claimed in claim 9, it is characterized in that: described dental care product is cleaning agent for mouth cavity, toothpaste, collutory, teeth consolidating cream, teeth consolidating powder, oral spray.
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| CN115177655A (en) * | 2022-07-18 | 2022-10-14 | 河北利华药业有限公司 | Preparation method of licorice extract and application of licorice extract in antibacterial and anti-inflammatory traditional Chinese medicine composition |
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| CN106692755A (en) * | 2017-01-03 | 2017-05-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition |
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| CN115177655A (en) * | 2022-07-18 | 2022-10-14 | 河北利华药业有限公司 | Preparation method of licorice extract and application of licorice extract in antibacterial and anti-inflammatory traditional Chinese medicine composition |
| CN115177655B (en) * | 2022-07-18 | 2023-07-25 | 河北利华药业有限公司 | Preparation method of licorice extract and application of licorice extract in antibacterial and anti-inflammatory traditional Chinese medicine composition |
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