CN104127356B - A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof - Google Patents
A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof, this combination liquid is refined thing, plants essential oil, cosolvent and sweeting agent made by Folium Hippophae decoction liquor, Fructus Hippophae, Folium Hippophae is decocted after completing, cools down, filters prepared decoction liquor by employing, after fresher sea buckthorn fruit being pulled an oar, by alcohol water blend reflux, extract, again by macroporous resin removing fruit is unfavorable for the impurity such as sugar and the fruit acid of dental health, again by Folium Hippophae decoction liquor, Fructus Hippophae refines thing, plants essential oil, sweeting agent % and cosolvent are formulated.Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid have for oral cavity and throat antibacterial, antiinflammatory, ease pain, stop blooding, eliminate the phlegm, the multiple efficacies such as fresh breath, raw materials used cheap and easy to get, for medicinal and edible plants, without artificial preservative's composition, have no side effect, fragrance is unique, easy to use.
Description
Technical field
The present invention relates to a kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof.
Background technology
Along with living standards of the people and health perception improve, oral hygiene is increasingly subject to the attention of people, World Health Organization's handle
Oral health is as one of the ten big standards of health.After feed, the residue in oral cavity can grow a lot of antibacterial, causes dental caries
And halitosis, when people's hormone in vivo secretes not normal or hypoimmunity, antibacterial amount reproduction will cause oral ulcer, periodontal
The diseases such as inflammation, tonsil inflammation and pharyngitis.The researcher of Univ Zurich Switzerland finds, streptococcus common in oral cavity
S.tigurinus, the blood capillary being entered periodontal tissue by the gingiva of inflammation also can induce cardiovascular disease.Therefore, for oral cavity
Build the healthy hygienic conditions of cleaning, to healthy extremely important.Collutory and spray can go deep into oral cavity and throat
Depths, cleaning effect is more thorough, and uses convenient.
Fructus Hippophae is the industrial crops that a kind of potentiality to be exploited is huge, and its fruit, leaf, root, seed all can be used as medicine.Eightth century of Christian era Tibetan medicine
In book " moon king's medicine examine ", just drug effect to Fructus Hippophae has done detailed record, is the medical record of relevant Fructus Hippophae the most the earliest,
All with the multiple disease of single Fructus Hippophae or compound treatment, Ministry of Public Health in 1977 in the traditional medicine of China dimension doctor, Tibetan medicine and Mongolian medicine
First Fructus Hippophae is formally listed in " Chinese Pharmacopoeia ".
Fructus Hippophae is rich in multivitamin, flavone, organic acid, terpenoid, sterol, carotenoid, unsaturated fatty acid etc.
Bioactive ingredients, has fine Development volue at cosmetics, health food and field of medicaments." China National medicine will " is remembered
State the Uighurs and control aphtha of the mouth and tongue and avitaminosis with Fructus Hippophae.Fructus Hippophae described in " Uigurs medicine will " has heat clearing away solution
Poison, blood stasis dispelling of subsiding a swelling, effect of pain relieving.Juice of Fructus Hippophae sugaring described in " desert area medicinal plants ", boiled water is taken after mixing it with water for controlling
Treat laryngopharynx swelling and pain.Therefore Fructus Hippophae just has treatment oral ulcer and the effect of laryngopharynx swelling and pain in tradition Uygur medicine.Fructus Hippophae
The compositions such as flavone in fruit, phenolic acid have stronger bacteriostasis to gram positive bacteria pathogenic in oral cavity, can be notable
Lowering the expression of the inflammation factor, promote macrophages phagocytic capacity, its powerful antioxidation can suppress inflammation to cause
Oxidativestress damage.Containing abundant isorhamnetin in sea buckthorn fruit, also there is the effect of relieving cough and asthma.
In Folium Hippophae in addition to containing compositions such as abundant flavone, organic acid, possibly together with substantial amounts of tannins, tooth can be made
Gingival hemorrhage blood capillary shrinks, and has local hemostatic effect.It is the strongest that India scientist research shows that Folium Hippophae extract has
Broad-spectrum antibacterial action, gram positive bacteria and gram negative bacteria are all had notable bacteriostasis, and are stronger nerve
Propylhomoserin enzyme inhibitor, all has stronger antivirus action to A type and Influenza B virus.
Through patent searching Application No. 200810002006.5, the invention entitled " mouth care containing hippophae plant extract
Compositions " in disclose employing hippophae plant extract preparation and have and alleviate oral tissue inflammation, suppress gingivitis, reduce
Dental plaque is formed and keeps or strengthen toothpaste, collutory and the dental floss that mammlian system is healthy.This formula uses sand
The extract that spine directly obtains via solvent extraction, and containing a large amount of sugars and fruit acid composition in ripe Fructus Hippophae.Wherein saccharide
Composition mainly includes glucose, fructose and ethyl glucuronide etc..Fruit acid constituents mainly includes malic acid, quinic acid, oxalic acid
With citric acid etc., its pulp pH is up to 2.3-3.2.Saccharide and fruit acid constituents are soluble in the traditional extraction solvent such as ethanol, water,
It is enriched with further during extracting, makes content in extract higher.Lower turn of the most streptococcic effect of carbohydrate content
Turn to acid so that dental enamel surface demineralization, and then form decayed tooth, and tooth is directly caused by fruit acid constituents especially
Corrosivity injures.This research use macroporous resin method Fructus Hippophae extracting solution is further refined, according to acrylic component,
The difference of Van der Waals force, hydrogen bond and ion exchange between carbohydrate content and active component and macroporous resin, by sugar and fruit acid class
Composition removes, it is to avoid the injury that tooth is caused by its life-time service.
Summary of the invention
Present invention aim at, it is provided that a kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof, this Fructus Hippophae oropharynx is antibacterial
Antiinflammatory combination liquid is refined thing, plants essential oil, cosolvent and sweeting agent made by Folium Hippophae decoction liquor, Fructus Hippophae, and using will
Folium Hippophae decocts after completing, cools down, filters prepared decoction liquor, then by after the making beating of fresh sea buckthorn fruit, water-soluble by ethanol
Liquid reflux, extract, then by macroporous resin removing fruit is unfavorable for the impurity such as sugar and the fruit acid of dental health, then by Fructus Hippophae
Leaf decoction liquor, Fructus Hippophae refines thing, plants essential oil, and sweeting agent % and cosolvent are formulated.Fructus Hippophae mouth of the present invention
Pharynx anti-inflammation combination liquid have for oral cavity and throat antibacterial, antiinflammatory, ease pain, stop blooding, eliminate the phlegm, fresh breath etc. many
Plant effect, raw materials used cheap and easy to get, for medicinal and edible plants, without artificial preservative's composition, have no side effect, fragrant
Taste is unique, easy to use.
A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention, each component of this combination liquid is with weight ratio for Fructus Hippophae essence
Thing 0-0.5% processed, plants essential oil is the plant Herba Menthae of edibility, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or ginger essential oil 0.01-0.03%,
Sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, and cosolvent is glycerol or edible ethanol 3-15%, husky
Folium jujubae decoction liquor 74.47-94.99% is made.
The preparation method of described Fructus Hippophae oropharynx anti-inflammation combination liquid, follows these steps to carry out:
A, fresh Folium Hippophae is cleaned, complete, heat with the pure water of mass volume ratio 10-30 times amount and decoct, extract 1
-4 times, each 1-3 hour, merge, cool down, filter prepared Folium Hippophae extracting solution；
B, fresh sea buckthorn fruit is clean, making beating, be that 30-70% alcohol heating reflux extracts by volumetric concentration, extracted
Liquid, then by extracting solution decompression distillation, reclaim ethanol, obtain Fructus Hippophae extracting solution；
Macroporous resin column on c, Fructus Hippophae extracting solution step b obtained, is that 0-10% ethanol rushes post by volumetric concentration, discards
Eluent, removes sugar and fruit acid, and continuation concentration is that 30-80% ethanol rushes post, eluent decompression distillation, reclaims ethanol,
It is spray-dried, obtains Fructus Hippophae and refine thing；
D. adding the Folium Hippophae extracting solution 74.47-94.99% that step a obtains in material-compound tank, Fructus Hippophae refines thing 0-0.5%,
Plants essential oil 0.01-0.03%, sweeting agent 2-10%, cosolvent is glycerol or edible ethanol 3-15%, stirring, centrifugal, takes
Supernatant is sterilized, fill, obtains Fructus Hippophae oropharynx anti-inflammation combination liquid.
Used in step c, macroporous resin is polystyrene resin, polyacrylics or ion exchange resin, its model
For AB-8, X-5, HPD-300, HPD-450, HPD-600 or HPD-700.
Described Fructus Hippophae oropharynx anti-inflammation combination liquid cleans in preparation maintains oral cavity, and fresh breath suppresses oral cavity bacterium
Breeding, alleviates oral ulcer, suppresses oral inflammation, alleviates dental pain, alleviates the purposes in the medicine of gingival hemorrhage.
A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention, the Fructus Hippophae in this combination liquid refines thing and Folium Hippophae carries
Taking the flavone in liquid, phenolic acid, tannin and alkaloids composition is main active component, and being aided with plant-derived essential oil provides perfume
Taste, strengthens anti-microbial property, and has antisepsis.It is molten that the method for the invention substitutes water with Folium Hippophae extracting solution decoction liquor
Agent enriches the active component in formula with antibacterial and anti-inflammation functions, makes resource more make full use of.The method utilizes medicine food to hold concurrently
It is raw material with plant resources Fructus Hippophae and Folium Hippophae, with reference to uighur's culture medicine ancient books and records use Fructus Hippophae treatment aphtha of the mouth and tongue
Method, in conjunction with the Fructus Hippophae found in domestic and international Natural products research and the nutritional labeling of Folium Hippophae and pharmacological action, Jing Guoke
Learn the Fructus Hippophae oropharynx anti-inflammation combination liquid of collocation and unique process for purification processing.
The present invention, with Folium Hippophae decoction liquor as solvent, adds flavone, phenolic acid isoreactivity composition in combination liquid, and Folium Hippophae
Middle tannin constituents also has convergence gingiva wound, reduces the effect of gingival hemorrhage.Folium Hippophae compares fruit, and resource is more honest and cleaner
Valency is easy to get, so that sea buckthorn resources is more fully utilized.
The present invention, can rapid damage and the polyphenol oxidase being passivated in fresh blade by the process that completes fresh Folium Hippophae
Enzyme, it is to avoid combination liquid enzymatic oxidation during preserving.
The present invention is raw materials used cheap and easy to get, and for medicinal and edible plants, without western medicine composition, the fragrance that has no side effect is unique.
The present invention combines in liquid containing a large amount of phenols components, preferably uses the container filling that dark bottles or other minimizing light irradiate,
Preferably keep in Dark Place, to reduce light-catalysed oxidation reaction.
The major function factor that Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid comprises has:
Flavone: containing becoming with isorhamnetin with the Quercetin flavonoid as aglycon in a large number in Fructus Hippophae oropharynx anti-inflammation combination liquid
Point, have and lower the expression of inflammatory factor, the oxidative stress of suppression inflammation initiation and improve the work of inflammation part vascular permeability
With, also there is certain antibacterial ability and analgesic activity, isorhamnetin also has effect of eliminating phlegm and stopping cough in addition.
Phenolic acid: the phenolic acid components in Fructus Hippophae oropharynx anti-inflammation combination liquid comprises gallic acid, protocatechuic acid, caffeic acid, water
Poplar acid, cinnamic acid, ferulic acid, vanillic acid etc., have the strongest antibacterial activity and anti-oxidation stress ability, infected by influenza
Also there is certain rejection ability, and there is stronger antiinflammatory action.
Tannin: containing a certain amount of tannin constituents in Fructus Hippophae oropharynx anti-inflammation combination liquid, gingival hemorrhage blood capillary can be made
Shrink, there is local hemostatic effect.And there is broad-spectrum antiseptic ability and stronger antiinflammatory action.
Alkaloid: have containing a certain amount of 5-hydroxy tryptamine and derivant thereof, this constituents in Fructus Hippophae oropharynx anti-inflammation combination liquid
There is certain analgesic activity.
Volatile oil: plants essential oil have antibacterial, analgesia, the effect of fresh breath.
Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid can be prepared as collutory or spray, but is not limited to both
Form, is used for keeping oral cavity cleaning, and the antibacterial reducing oral cavity and throat infects and the generation of inflammation.
Detailed description of the invention
Following example are not limited only to the scope of the invention:
Embodiment 1
Prepared by Folium Hippophae decoction liquor:
Being cleaned by fresh Folium Hippophae, add parch pot, 200 DEG C of high temperature quickly complete, and take the rear blade 1kg that completes, pure with 10L
Water purification heating decocts extracts 4 times, each 1 hour, merges, cools down, filters prepared Folium Hippophae extracting solution；
Fructus Hippophae refines thing to be prepared:
Fresh sea buckthorn fruit 1kg is cleaned, pull an oar, be that 60% alcohol heating reflux extracts by volumetric concentration, obtain extracting solution,
Again by extracting solution decompression distillation, reclaim ethanol, obtain Fructus Hippophae extracting solution；
By AB-8 macroporous adsorptive resins on Fructus Hippophae extracting solution, rush post with volumetric concentration 10% ethanol, discard eluent, remove
Go sugar and fruit acid, continuation volumetric concentration 50% ethanol to rush post, eluent decompression distillation, reclaim ethanol, be spray-dried,
Obtain Fructus Hippophae and refine thing 52g；
Preparation total amount is the collutory of 10L:
Fructus Hippophae refines thing 50g, cumin essential oil 3g, xylitol 1kg, glycerol 1L, and Folium Hippophae decoction liquor 9L adds and joins
In batch can, stirring and dissolving, centrifugal, by supernatant high-temperature sterilization, fill, obtain Fructus Hippophae anti-inflammation collutory.
Embodiment 2
Prepared by Folium Hippophae decoction liquor:
Being cleaned by fresh Folium Hippophae, add green steaming chamber, steam high temperature quickly completes, and takes the rear blade 1kg that completes, uses 30L
Pure water heating decocts 3 hours, extracts 1-4 time, each 1-3 hour, and merging cools down, filters prepared Folium Hippophae and carry
Take liquid；
Fructus Hippophae refines thing to be prepared:
Fresh sea buckthorn fruit 1kg is cleaned, pull an oar, be that 30% alcohol heating reflux extracts by volumetric concentration, obtain extracting solution,
Again by extracting solution decompression distillation, reclaim ethanol, obtain Fructus Hippophae extracting solution；
By HPD-450 macroporous resin column on Fructus Hippophae extracting solution, rush post with pure water, discard eluent, remove sugar and fruit acid,
Continuation concentration is that 30% ethanol rushes post, eluent decompression distillation, reclaims ethanol, is spray-dried, obtains Fructus Hippophae and refine thing
61g；
Preparation total amount is the collutory of 10L:
Fructus Hippophae is refined thing 10g, Mentholum 2g, sorbitol 500g, edible ethanol 500mL, Folium Hippophae decoction liquor 9.5L
Add in material-compound tank, stirring and dissolving, centrifugal, take supernatant sterilization, fill, obtain Fructus Hippophae anti-inflammation collutory.
Embodiment 3
Prepared by Folium Hippophae decoction liquor:
Fresh Folium Hippophae is cleaned, adds microwave deactivation of enzyme machine and quickly complete, take the rear blade 1kg that completes, add with 20L pure water
Heat decocts 2 times, each 2 hours, prepares Folium Hippophae decoction liquor；
Preparation total amount is the throat spraying agent of 10L:
By Flos Rosae Rugosae quintessence oil 1g, stevioside 200g, edible ethanol 300mL, Folium Hippophae decoction liquor 9.7L adds in material-compound tank,
Stirring and dissolving, centrifugal, take supernatant sterilization, fill, obtain Fructus Hippophae anti-inflammation throat spraying agent.
Embodiment 4
Prepared by Folium Hippophae decoction liquor:
Being cleaned by fresh Folium Hippophae, add green steaming chamber, steam high temperature quickly completes, and takes the rear blade 1kg that completes, pure with 20L
Water purification heating decocts, and extracts 1 time, 2 hours, merges, cool down, filter prepared Folium Hippophae extracting solution；
Fructus Hippophae refines thing to be prepared:
Fresh sea buckthorn fruit 1kg is cleaned, pull an oar, be that 70% alcohol heating reflux extracts by volumetric concentration, obtain extracting solution,
Again by extracting solution decompression distillation, reclaim ethanol, obtain Fructus Hippophae extracting solution；
By X-5 macroporous resin column on Fructus Hippophae extracting solution, it is that 5% ethanol rushes post by concentration, discards eluent, remove sugar and fruit
Acid, continuation concentration is that 50% ethanol rushes post, eluent decompression distillation, reclaims ethanol, is spray-dried, obtains Fructus Hippophae essence
Thing 55g processed；
Preparation total amount is the collutory of 10L:
Fructus Hippophae is refined thing 30g, ginger essential oil 3g, saccharin sodium 500g, edible ethanol 1.5mL, Folium Hippophae decoction liquor 8.5L
Add in material-compound tank, stirring and dissolving, centrifugal, take supernatant, sterilization, fill, obtain Fructus Hippophae anti-inflammation collutory.
Embodiment 5
Prepared by Folium Hippophae decoction liquor:
Being cleaned by fresh Folium Hippophae, add parch pot, 200 DEG C of high temperature of temperature quickly complete, and take the rear blade 1kg that completes, use 10L
Pure water heating decocts 3 times, each 2 hours, merges, cools down, filters prepared Folium Hippophae extracting solution；
Fructus Hippophae refines thing to be prepared:
Fresh sea buckthorn fruit 1kg is cleaned, pull an oar, be that 50% alcohol heating reflux extracts by volumetric concentration, obtain extracting solution,
Again by extracting solution decompression distillation, reclaim ethanol, obtain Fructus Hippophae extracting solution；
By HPD-600 macroporous resin column on Fructus Hippophae extracting solution, it is that 10% ethanol rushes post by concentration, discards eluent, remove sugar
Divide and fruit acid, continue to rush post, eluent decompression distillation with 80% ethanol, reclaim ethanol, spray drying, obtain Fructus Hippophae essence
Thing 58g processed；
Preparation total amount is the collutory of 10L:
Fructus Hippophae refines thing 40g, cumin essential oil 1g, xylitol 800g, glycerol 1L, and Folium Hippophae decoction liquor 9L adds and joins
In batch can, stirring and dissolving, centrifugal, take supernatant, sterilization, fill, obtain Fructus Hippophae anti-inflammation collutory.
Embodiment 6
Fructus Hippophae oropharynx anti-inflammation combination liquid Determination of Antibacterial Activity:
Take solid LB media 20mL respectively, microwave oven is heated to boiling, is cooled to temperature 37 DEG C, is separately added into golden yellow
Color staphylococcus bacterium solution and each 1mL of Escherichia coli bacteria liquid, then take solid BHI culture medium 20mL, microwave oven is heated to boiling,
It is cooled to temperature 37 DEG C, adds Streptococcus mutans bacterium solution 1mL, three kinds of culture medium are layered on culture dish the most uniformly, treat
After each culture medium cooled and solidified, punching in culture medium with diameter 6mm iron pipe, in hole, precision adds embodiment 1-5 institute respectively
Obtain Fructus Hippophae oropharynx anti-inflammation combination liquid 20 μ L, fully absorb to culture medium until solution, put into constant incubator, temperature
Place 24h for 37 DEG C, measure inhibition zone diameter, be shown in Table 1:
Table 1 Fructus Hippophae of the present invention oropharynx anti-inflammation combination liquid antibacterial action testing result
Conclusion: outside Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid, there is good antibacterial action.
Embodiment 7
Fructus Hippophae oropharynx anti-inflammation combination liquid observation of curative effect:
64 example patients (oral ulcer 36 example, laryngopharynx swelling and pain 28 example) are randomly divided into experimental group and matched group, often organize each 32
Example patient (oral ulcer 18 example, laryngopharynx swelling and pain 14 example), experimental group uses the Fructus Hippophae oropharynx prepared by embodiment 1 method
Anti-inflammation collutory, matched group uses commercially available collutory, uses after the meal, each rinsing the mouth 30 seconds, uses 3 days continuously,
Period does not use other drug or oral care product.
The present invention achieves preferable curative effect in an experiment: 15 examples recoveries from illness, 3 example symptoms in experimental group 18 example oral ulcer patient
Substantially alleviating, in 14 example laryngopharynx swelling and pain patients, 8 example recoveries from illness, 6 example symptoms substantially alleviate, and total effective rate all reaches 100%；Comparison
Organize in 18 example oral ulcer patients 9 example patients recoveries from illness, 7 example symptoms alleviate, 5 examples recoveries from illness in 14 example laryngopharynx swelling and pain patients, 6
Example symptom alleviates, and total effective rate is respectively 88.9% and 78.6% and is substantially less than experimental group.
Conclusion: Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid has good treatment and alleviates oral ulcer and laryngopharynx swelling and pain
Effect.
Claims (2)
1. the preparation method of a Fructus Hippophae oropharynx anti-inflammation combination liquid, it is characterized in that each component of this combination liquid refines thing 0-0.5% with weight ratio for Fructus Hippophae, plants essential oil is the plant Herba Menthae of edibility, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or ginger essential oil 0.01-0.03%, sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, cosolvent is glycerol or edible ethanol 3-15%, Folium Hippophae decoction liquor 74.47-94.99% is made, and concrete operations follow these steps to carry out:
A, fresh Folium Hippophae is cleaned, complete, heat with the pure water of mass volume ratio 10-30 times amount and decoct, extracts 1-4 time, each 1-3 hour, merging, cool down, filter prepared Folium Hippophae extracting solution；
B, fresh sea buckthorn fruit is clean, making beating, be that 30-70% alcohol heating reflux extracts by volumetric concentration, obtains extracting solution, then by extracting solution decompression distillation, recovery ethanol, obtains Fructus Hippophae extracting solution；
Macroporous resin column on c, the Fructus Hippophae extracting solution that step b is obtained, it is that 0-10% ethanol rushes post by concentration, discarding eluent, remove sugar and fruit acid, continuation volumetric concentration is that 30-80% ethanol rushes post, eluent decompression distillation, reclaim ethanol, be spray-dried, obtain Fructus Hippophae and refine thing, used in it, macroporous resin is polystyrene resin, polyacrylics or ion exchange resin, and its model is AB-8, X-5, HPD-300, HPD-450, HPD-600 or HPD-700；
D. in material-compound tank, add the Folium Hippophae extracting solution 74.47-94.99% that step a obtains, Fructus Hippophae refines thing 0-0.5%, plants essential oil is the plant Herba Menthae of edibility, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or ginger essential oil 0.01-0.03%, sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, and cosolvent is glycerol or edible ethanol 3-15%, stirring, centrifugal, take supernatant sterilization, fill, obtain Fructus Hippophae oropharynx anti-inflammation combination liquid.
2. Fructus Hippophae oropharynx anti-inflammation combination liquid cleaning in preparation maintains oral cavity that a method as claimed in claim 1 obtains, fresh breath, suppression oral cavity bacterium breeding, alleviate oral ulcer, suppression oral inflammation, alleviates dental pain, alleviates the purposes in the medicine of gingival hemorrhage.
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| CN106727007A (en) * | 2017-01-02 | 2017-05-31 | 李大兴 | A kind of sea-buckthorn anti-aging toothpaste |
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| US20080166307A1 (en) * | 2007-01-10 | 2008-07-10 | Jose Eder Fontana | Oral Care Compositions Comprising a Hippophae Extract |
| CN102058634B (en) * | 2011-01-04 | 2012-08-29 | 鄂尔多斯市天骄资源发展有限责任公司 | Method for extracting and purifying total flavonoids of sea buckthorn |
| CN103054915A (en) * | 2012-12-13 | 2013-04-24 | 大兴安岭林格贝有机食品有限责任公司 | Novel production process for total flavones of hippophae rhamnoides |
| CN103417588A (en) * | 2013-08-23 | 2013-12-04 | 中国科学院新疆理化技术研究所 | Preparation method of effective part of Hippophae rhamnoides |
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