CN113509537B - Jiangyao bath composition capable of expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome as well as preparation method and application thereof - Google Patents

Jiangyao bath composition capable of expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome as well as preparation method and application thereof Download PDF

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CN113509537B
CN113509537B CN202110435588.3A CN202110435588A CN113509537B CN 113509537 B CN113509537 B CN 113509537B CN 202110435588 A CN202110435588 A CN 202110435588A CN 113509537 B CN113509537 B CN 113509537B
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jiangyao
bath
mass
bath composition
cold
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CN113509537A (en
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史劲松
钱建瑛
秦安琪
石漱新
郑可欣
江佳宇
王芝艳
冯雨萌
蒋敏
龚劲松
许正宏
陈德润
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Congjiang Cultural Tourism Investment And Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483Gleditsia (locust)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention relates to a Jiangyao bath composition for expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome, and a preparation method and application thereof, and the Jiangyao bath composition for expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome comprises 40-60g of cassia twig, 25-45g of dried ginger, 10-15g of suberect spatholobus stem, 30-50g of folium artemisiae argyi, 20-30g of Chinese honeylocust fruit, 10-20g of Chinese soapberry, 50-80g of citronella and 10-20g of pepper. The Jiangyao bath lotion provided by the invention can accelerate the blood circulation of the whole body, remarkably promote sweating, and achieve the purposes of reducing the body temperature, relieving aversion to cold, headache, soreness of limbs, cough and other cold symptoms by opening the striae of skin and skin, dispersing exterior syndrome and expelling evil. The Jiangyao bath lotion is convenient to use, and can be used for soaking and bathing after one bottle of bath lotion is poured into water with the temperature of 40-43 ℃ and is stirred uniformly.

Description

Jiangyao bath composition capable of expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome as well as preparation method and application thereof
Technical Field
The invention belongs to the technical field of national medicinal material treatment, and particularly relates to a Jiangyao bathing composition capable of expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome, and a preparation method and application thereof.
Background
The Yao nationality is a famous long-life ethnic group, in the Yao nationality region, not only the Yao elders above 80 years old can also go up mountain and cut firewood, and go down to the ground and live, but also the hundred years old with healthy physique can be seen everywhere, which is not separated from the living habit of the Yao nationality generation favorite bathing. Also because of this, the second non-material cultural heritage protection directory was incorporated from the Jiangyao bath, also known as the "Green health track", into the selected countries.
Whether severe cold or severe summer heat, Yao people working for one day can enjoy bath from Jiang Yao, and the medicated bath is not only the life custom of local people, but also a health-care method for preventing and treating diseases and preserving health. As Yao nationality people mostly live in the deep mountains, the capacity of treating diseases by soaking and bathing branches, leaves, roots, skins and flowers of plants is formed in the long-term struggle with severe environments and diseases.
Dozens of medicinal materials or even hundreds of medicinal materials are collected from plants in the deep mountains, and the medicinal materials mainly have the effects of promoting blood circulation to remove blood stasis, regulating qi and regulating menstruation, dispelling wind and removing dampness, beautifying and moistening skin, relieving fatigue and refreshing mind and the like. In addition, Yao nationality also has a famous three-day work-out medicated bath specially used for washing and soaking postpartum women, and parturient can take a homework after soaking for three days, so that the body recovery is facilitated. Generally, the medicated bath selects the medicines with the effects of warming and invigorating, promoting blood circulation and removing blood stasis, such as sargentgloryvine stem, hispid fig, sarcandra glabra, eucommia bark stem and the like, promotes the recovery of the uterus of a lying-in woman, nourishes blood and qi, and prevents various infections, and is also called as a monthly medicated bath.
The bath from Jiangyao province is characterized by 'three broken' and 'three clear'. The three-breaking refers to breaking, breaking and breaking stagnation, wherein the silt is the blockage of the pipeline, the stagnation is the blocking of the pipeline, and the stagnation is the viscosity of the fluid; the three-clear means clearing the intestines and stomach, clearing the blood vessels and clearing the cells. By soaking in the bath of Jiang Yao, the effects of clearing away heat and toxic materials, dispelling pathogenic wind and cold, nourishing qi and blood, relieving fatigue, promoting sleep, regulating endocrine, and enhancing immunity can be achieved. The bathing lotion can achieve good cleaning effect without using body lotion in the Jiangyao bath, and because of the pure natural herbal materials, sweat and dust blocking pores can be cleaned, and skin aging is delayed. In the bathing process, garbage and harmful substances in cells and blood vessels of a human body can be discharged out of the body along with sweat, and some medicines can increase the consumption of heat of the human body and have the effects of reducing fat and losing weight.
Although the Jiangyao bath is good, the modern production process of Jiangyao bath products needs to be accelerated, the production process needs to be improved, and the quality standard control needs to be enhanced. Firstly, starting from the research and identification of the variety of Yao medicine, the problem that local common names, local names and plant classified names are not corresponding is solved; secondly, folk prescriptions and proved folk prescriptions are collected fully, and the pharmacological action and safety problems of the folk prescriptions are solved by a modern research method; at present, related products in the market are fewer, and the product is particularly suitable for industrial production.
Disclosure of Invention
In order to solve the technical problems, the invention provides a Jiangyao bath composition which can effectively expel wind and clear away cold, induce sweating and relieve superficial syndrome, and provides an industrial preparation method and an application method of the composition in related products.
The invention aims to provide a Jiangyao bath composition for expelling wind, clearing away cold, inducing sweat and relieving exterior syndrome, which comprises 40-60g of cassia twig, 25-45g of dried ginger, 10-15g of caulis spatholobi, 30-50g of folium artemisiae argyi, 20-30g of Chinese honeylocust fruit, 10-20g of soapberry, 50-80g of citronella and 10-20g of pepper.
Furthermore, the bath composition from Jiangyao province is prepared from 40-60g of cassia twig, 25-45g of dried ginger, 10-15g of caulis spatholobi, 30-50g of folium artemisiae argyi, 20-30g of saponin, 10-20g of Chinese soapberry, 50-80g of citronella and 10-20g of pepper.
Furthermore, the Jiangyao bath composition comprises 40g of cassia twig, 25g of dried ginger, 10g of caulis spatholobi, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
Furthermore, the bath composition from Jiangyao province is prepared from the following raw materials of 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The second purpose of the invention is to provide a preparation method of the bath composition from Jiang Yao, which is to extract and prepare the bath composition from Jiang Yao according to the following method:
(1) weighing the medicinal materials respectively, and pulverizing the medicinal materials;
(2) mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding water, extracting at 60-80 ℃ for 5-8 hours, filtering an extracting solution, and concentrating to obtain a first concentrated solution with the volume being 1-3 times of the mass of the medicinal materials for later use;
(3) mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol water solution with the volume fraction of 10-40%, performing reflux extraction at the temperature of 60-80 ℃ for 2-4 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating to the volume of 1-3 times of the mass of the medicinal materials to obtain a second concentrated solution for later use;
(4) mixing the first concentrated solution and the second concentrated solution, filtering, bottling, and sealing.
Further, in the step (1), the pulverization is to pulverize the medicinal materials into particles which can pass through a standard sieve of 10 meshes.
Further, in the step (2), water is added according to the mass-to-volume ratio of 1: 5-8.
Further, in the step (3), an ethanol aqueous solution is added according to the mass-to-volume ratio of 1: 2-5.
The third purpose of the invention is to provide the application of the Jiangyao bath composition in preparing a medicine for treating exogenous fever.
The fourth purpose of the invention is to provide a Jiangyao bath lotion which comprises the Jiangyao bath composition.
By means of the scheme, the invention at least has the following advantages:
the Jiangyao bath lotion provided by the invention can accelerate the blood circulation of the whole body, remarkably promote sweating, and achieve the purposes of reducing the body temperature, relieving aversion to cold, headache, soreness of limbs, cough and other cold symptoms by opening the striae of skin and skin, dispersing exterior syndrome and expelling evil. The Jiangyao bath lotion is convenient to use, and can be used for soaking and bathing after a bottle of bath lotion is poured into water with the temperature of 40-43 ℃ and is stirred uniformly.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a preferred embodiment of the present invention and is described in detail below.
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention and to clearly and clearly define the scope of the present invention.
The prescription of the invention is combined with the modern pharmacological principle, and is compatible according to the monarch, minister, assistant and guide principles of the traditional Chinese medicine theory:
the principal drug is citronella. The lemongrass is one of common vanilla, the essential oil of the lemongrass is the most widely used essential oil in aromatherapy, is native to tropical regions of southeast Asia, has the effects of treating exogenous exterior syndromes, measles, rubella, sores and the like when being taken orally, and is a main food material and a characteristic flavor source of a characteristic dish Dongyuan-Yin decoction in southeast Asia. The inventor finds that the traditional Chinese medicine composition has an oral effect, has a very strong sweating and exterior syndrome relieving effect through bathing, has fresh fragrance, enables a patient to feel cool and refreshing when bathing, and remarkably relieves symptoms of dizziness and fatigue during cold.
The ministerial drug is ramulus Cinnamomi. Ramulus Cinnamomi is a traditional Chinese medicine of Camphor mesh, has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels and collaterals, supporting yang, regulating qi, and can be used for treating common cold by combining with radix Paeoniae and herba Ephedrae. The inventor finds that the combination of the traditional Chinese medicine composition and the citronella is beneficial to promoting the citronella to have the efficacy of sweating and relieving exterior syndrome and relieving the symptoms of headache and neck and back pain after cold.
The adjuvant materials include Zingiberis rhizoma and folium Artemisiae Argyi. Zingiberis rhizoma has effects of warming spleen and stomach for dispelling cold, warming lung and resolving fluid retention, and Artemisiae Argyi folium is mainly used for warming channels to stop bleeding, dispelling cold and relieving pain. Can be used as a guiding drug to assist in treating symptoms such as common cold, cough, aversion to cold, etc.
The guiding drug is caulis Spatholobi. Caulis Spatholobi has the main effects of promoting blood circulation, replenishing blood, regulating menstruation and relieving pain, and is commonly used for treating menoxenia, dysmenorrhea, amenorrhea, rheumatalgia, etc. The inventor finds that the Yao bath formula containing the Yao bath has the effects of introducing the medicine into blood and entering muscles and bones, and has the effects of helping the adjuvant medicine warm the channel and dispel cold and helping the monarch and ministerial medicines to dispel seasonal pathogens of muscles and bones.
The other medicines such as fructus Gleditsiae Abnormalis, fructus Sapindi Mukouossi and fructus Zanthoxyli are added according to modern pharmacological research. Because the formula of the invention is mainly used for bathing, according to the components of the medicine and the modern pharmacological action, the Chinese honeylocust fruit, the soapberry and the pepper are added to play the effect of the natural surfactant, so that the bath lotion can remove sweat stains and dirt on the body, has refreshing feeling and reduces the feeling of fatigue and weight of a patient.
Example 1:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. crushing the medicinal materials, and sieving the medicinal materials by a sieve of 50-60 meshes;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol water solution with the volume fraction of 30% according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 2:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. mixing cassia twig, dried ginger, caulis spatholobi, Chinese honeylocust fruit and soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting at 70 ℃ for 6 hours, filtering the extracting solution, and concentrating to 2 times of the volume of the medicinal material for later use;
3. mixing folium artemisiae argyi, citronella and pepper, adding 30% ethanol aqueous solution according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering the extracting solution, recovering ethanol until no alcohol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 3:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 30g of folium artemisiae argyi, 20g of saponin, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting at 70 ℃ for 6 hours, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol water solution with the volume fraction of 30% according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 4:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the pulverized citronella and the pepper, adding 30% ethanol aqueous solution according to the mass-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering the extracting solution, recovering ethanol until no alcohol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 5:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger and the caulis spatholobi, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol aqueous solution with the volume fraction of 30% according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. the two concentrates were mixed, filtered, bottled and sealed, but the product prepared in this example showed increased sedimentation upon mixing.
Example 6:
the formula of Jiangyao bath is as follows: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding pure water according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 7:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding 70% ethanol water solution according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering the extracting solution, recovering ethanol until no alcohol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 8:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, and concentrating to the volume which is 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding 30% ethanol water solution according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 6 hours, filtering the extracting solution, recovering ethanol until no alcohol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 9:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit, the Chinese soapberry fruit, the folium artemisiae argyi, the citronella and the pepper, adding pure water according to the mass-to-volume ratio of 1:6, extracting for 6 hours at 70 ℃, filtering an extracting solution, concentrating to 2 times of the volume of the medicinal material, bottling and sealing. However, the present example showed precipitation after a period of standing after the bottle was sealed.
Example 10:
formula of Jiangyao bath: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
The preparation method comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit, the soapberry, the folium artemisiae argyi, the citronella and the pepper, adding an ethanol aqueous solution with the volume fraction of 30% according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, concentrating until the volume is 2 times of the mass of the medicinal materials, bottling and sealing. However, the present example showed precipitation after a period of standing after the bottle was sealed.
Example 11:
a formula of Jiang Yao bath for expelling wind and clearing away cold, inducing sweat and relieving exterior syndrome comprises the following components: the traditional Chinese medicine composition comprises, by mass, 40g of cassia twig, 25g of dried ginger, 10g of suberect spatholobus stem, 30g of folium artemisiae argyi, 20g of Chinese honeylocust fruit, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
Secondly, the preparation method of the bath lotion from Jiangyao nationality comprises the following steps:
1. pulverizing the medicinal materials, and sieving with 10 mesh standard sieve;
2. mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding pure water according to the mass-to-volume ratio of 1:6, extracting at 70 ℃ for 6 hours, filtering an extracting solution, and concentrating to the volume 2 times of the mass of the medicinal materials for later use;
3. mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol water solution with the volume fraction of 30% according to the mass-to-volume ratio of 1:3, carrying out reflux extraction at 70 ℃ for 3 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating until the volume is 2 times of the mass of the medicinal materials for later use;
4. mixing the two concentrated solutions, filtering, bottling, and sealing.
Example 12:
120 patients with fever, 46 men and 74 women; mean age (27.4 ± 4.3) years; 55 children, 3-16 years old, 33 middle-aged and young, 23-45 years old, 32 old people, 65-85 years old. The main clinical manifestations are: fever (body temperature 38.4-41.3 ℃), headache, aversion to cold, aversion to wind, no sweat, polydipsia, floating pulse, general pain in middle-aged and old patients, soreness of limbs, cough and pharyngalgia in children. Dividing the patients into two groups, wherein the treatment number is odd number and is used as an observation group, and 66 cases are totally included, wherein 25 cases of children, 19 cases of young and middle-aged people and 22 cases of old people; the controls were given in 54 cases with even mantissas, 30 children, 14 middle-aged and young, and 10 elderly. The difference of age, sex, etiology, course of disease, clinical manifestation and degree of fever of the two groups of people has no significant meaning (P is more than 0.05), and the two groups of people have comparability.
Two groups of patients are treated according to the requirements of illness states, such as transfusion, anti-infection, support and the like according to the advice of doctors, the traditional Chinese medicine for relieving exterior syndrome or the traditional Chinese medicine for Chinese patent medicine is taken in a control group, and the bathing liquid provided by the scheme of the embodiment 11 of the invention is used in an observation group, and the specific operation is as follows: pouring a bottle of bath lotion into water at 40-43 deg.C, and stirring to obtain bath lotion; the water consumption for bathing is that the water level reaches the position of the chest; the duration time of each bath is determined according to the physique and the disease condition of a patient, the physique is strong, the obese patient takes bath for more than 20 minutes until the whole body generates heat and perspires, and the emaciation and the weakness patient takes bath for more than 10 minutes until the whole body generates sweat; generally, each patient takes a bath once a day, and the second bath can be performed the next day for the patient who does not have obvious body temperature drop after sweating through individual bath, and the bath time is properly prolonged to increase the sweating amount. Before operation, the aim of bathing is explained for patients and family members, coordination is achieved, a door window is closed to avoid wind, and the patients are encouraged to drink 300-1000 mL of warm water in the bathing process to promote body sweating; when the patient feels dysphoria with feverish sensation, the forehead is applied with cold towel and the replacement is frequently carried out, so as to relieve the uncomfortable feeling of the head. After the bathing is finished, the sweat is timely wiped by a dry towel, the patient can change clothes, lie in bed for rest, keep out wind and keep warm, and measure the body temperature again after 1 hour, so that the patient is encouraged to drink warm boiled water more to supplement body fluid.
And (3) evaluating the curative effect: both groups of patients were evaluated for efficacy in 72 hours. The body temperature is reduced to below 37.5 ℃, repeated fever, aversion to cold, aversion to wind, headache, sore throat, body pain and limb ache can not disappear within 72 hours, and cough can be cured; the body temperature is reduced to below 37.5 ℃, repeated fever, aversion to cold, aversion to wind, headache, sore throat, body pain and limb ache are not caused in 72 hours, and the cough is relieved obviously; the body temperature did not drop or increased, or fever was repeated within 72 hours, and other symptoms were not relieved and were ineffective. The two groups of therapeutic effects were compared and are shown in Table 1 below.
Table 1 two comparative efficacy groups (examples/%)
Group of Number of examples Healing process Show effect Invalidation Total effective
Observation group 66 34 26 6 90.9%
Control group 54 25 19 10 81.5%
As can be seen from the table above, the bath liquid provided by the scheme of the invention has better curative effect on the patient with exogenous fever.
Example 13: content of piperitone in bath lotion
According to the scheme provided by the invention, a large amount of aromatic medicinal materials are used in the formula of the Jiangyao bath lotion, and the main effective components are volatile substances, so that the specific components contained in the formula are analyzed by a headspace solid phase microextraction-gas chromatography-mass spectrometry combined detection method. The experimental method is as follows: a65 mu m PDMS/DVB extraction fiber head is selected, the sampling amount is 0.6g, the extraction temperature is 60 ℃, the extraction time is 15min, and the desorption time is 3 min. GC conditions were as follows: HP-5MS quartz capillary column (30m × 0.25mm, 0.25 μm); carrier gas: high-purity He; flow rate: 0.8 mL/min; sample inlet temperature: 230 ℃; temperature rising procedure: heating to 230 deg.C at 10 deg.C/min from 50 deg.C, and keeping for 3 min. MS conditions: an EI source; the ion source temperature is 230 ℃; ionization voltage 70 eV; the temperature of a four-level bar is 150 ℃; the scanning mass range is 35-550 m/z. The effective ingredients exemplified in examples 13 to 18 were analyzed by this method.
The formula of the Jiangyao bath lotion provided by the scheme of the invention uses the lemongrass. Cymbopogon citratus, named as lemongrass, lysimachia foenum-graecum hance, lysimachia christinae hance, and all the kudzu vine grasses, are whole herbs of lemongrass of the genus Cymbopogon of the family Gramineae, have the effects of relieving exterior syndrome, promoting diuresis, relieving cough and asthma when used as a medicine, and have the treatment effects on diseases such as wind-cold type common cold, sunstroke, vomiting and diarrhea, abdominal pain caused by urine, pain caused by wind-cold, rheumatalgia, cough and asthma, and the like. Wherein one of the effective components is piperitone. The fresh lemongrass contains volatile oil 0.7-1.0%, leaf contains volatile oil about 1.8%, flower axis about 0.5%, and stem is less than 0.05%. The volatile oil contains 40-50% piperitone.
Piperitone is practically insoluble in water and soluble in oils and alcohols. Has fragrance similar to camphor and mint. It is naturally found in oleum Eucalypti, oleum Menthae Dementholatum, and citronella oil. Piperitone has: (1) relieving asthma: for bronchospasm of guinea pig caused by histamine spray, the volatile oil contained in herba Cymbopogonis Citrari has obvious antagonistic effect by intramuscular injection of 2.4 ml/kg, and piperitone separated from herba Cymbopogonis Citrari oil has the same or stronger effect at 1.2 ml/kg; (2) cough relieving effect: the rue oil and piperitone (2.4 ml/kg, intramuscular injection) have obvious inhibition effect on cough reflex caused by electrically stimulating the superior laryngeal nerves of guinea pigs, and when the dosage of the latter is reduced by half, the effect is still stronger than that of the rue oil; (3) and (3) antibacterial action: 18 kinds of bacteria such as streptococcus A, streptococcus B, pneumococcus and staphylococcus aureus separated from the sputum of the elderly patients with chronic tracheitis are proved to have certain antibacterial effect by a paper sheet method.
The piperitone and the content thereof are very key to the bath lotion playing the roles of sweating and relieving exterior syndrome (cough and bacterial infection are western medicine symptoms corresponding to the exterior symptoms of the traditional Chinese medicine). The baths prepared in examples 1-11 were used, wherein the piperonyl ketone content is shown in table 2 below.
TABLE 2 Piperazone content (%)
Examples Piperitone content Examples Piperitone content Examples Piperitone content
1 0.36 4 0.27 7 0.38
2 0.34 5 0.38 8 0.25
3 0.43 6 0.22 9 0.27
10 0.29 11 0.57
Example 14: content of citral in the bath
Another important component in Cymbopogon citrates is citral. Citral, also known as neral, geranial, is colorless or yellowish liquid, has a strong lemon flavor, is easily soluble in oil, propylene glycol and ethanol, and is insoluble in glycerol and water. Naturally occurring in litsea cubeba oil (about 80%), lemongrass oil (80%), Ocimum gratissimum oil (65%), lime leaf oil (35%), etc. Can be isolated from natural essential oil in industry, or prepared by chemical synthesis. Has effects in sterilizing, killing bacteria, and treating neuralgia and myalgia; has effects in killing and expelling insects; the preservative effect is stronger than that of phenol.
The citral and the content thereof are very key for the bath lotion to play the roles of sweating and relieving exterior syndrome (neuralgia, myalgia and bacterial infection are western medicine symptoms corresponding to the wind-cold type common cold syndrome in the traditional Chinese medicine).
The baths prepared in examples 1 to 11 were used, wherein the citral content is shown in table 3 below.
TABLE 3 citral content (%)
Examples Citral content Examples Citral content Examples Citral content
1 0.42 4 0.42 7 0.37
2 0.42 5 0.57 8 0.46
3 0.63 6 0.34 9 0.35
10 0.39 11 0.86
Example 15: content of shogaol in bath lotion
The dried ginger is used in the formula of the Jiangyao bath lotion provided by the scheme of the invention. The Zingiberis rhizoma is dried rhizome of Zingiber officinale Rosc of Zingiberaceae, and has the effects of fragrant and specific smell, pungent taste, warming spleen and stomach for dispelling cold, restoring yang for dredging collaterals, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, emesis and diarrhea, cold limbs, slight pulse, phlegm retention, asthma and cough. (1) The alcohol extract of Zingiberis rhizoma has exciting effect on blood vessel movement center and respiratory center. The dried ginger extract has obvious analgesic effect on an acetic acid-induced pain mouse model, and can reduce the times of writhing reaction; (2) has antipyretic effect. The essential oil of rhizoma Zingiberis has antipyretic effect on body temperature of yeast-induced fever rat, and can be administered to beer yeast to make model of rat fever model, and has antipyretic effect after being treated by essential oil of rhizoma Zingiberis (0.375ml/kg/h) for 5 hr. One of the main components in the dried ginger essential oil is shogaol which can dilate blood vessels and promote blood circulation. These effects are all beneficial to the bath lotion to exert the effects of dispelling wind and cold, sweating and relieving exterior syndrome.
The baths prepared in examples 1-11 were used, wherein the shogaol content is shown in table 4 below.
TABLE 4 shogaol content (%) -of baths prepared according to different preparation methods
Examples Shogaol content Examples Shogaol content Examples Shogaol content
1 0.21 4 0.31 7 0.37
2 0.22 5 0.28 8 0.34
3 0.20 6 0.33 9 0.28
10 0.29 11 0.54
Example 16: bath lotion with linalool content
According to the formula of the Jiangyao bath lotion, the dried ginger and the pepper are used, and essential oil of the dried ginger and the pepper contains a large amount of linalool.
Zanthoxylum bungeanum has effects of warming middle-jiao and promoting qi circulation, expelling cold, relieving pain, and killing parasite, and can be used for treating stomach and abdomen psychroalgia, emesis, diarrhea, schistosome, ascariasis, etc., and also used as epidermal anesthetic. The pepper fruits contain 0.7 percent of volatile oil (produced in Guizhou), 2 to 4 percent of volatile oil (produced in Gansu) and 4 to 9 percent of volatile oil (produced in Guangdong), the linalool in the volatile oil of the fruits accounts for 9.10 percent, and the linalool in the volatile oil of the pepper seeds accounts for 18.5 percent. The Chinese prickly ash peel is prepared into 50% injection for intramuscular injection or acupoint injection, 2 ml of the injection is used for each time, the injection is effective on abdominal pain (ulcer pain, enterospasm, biliary colic), liver pain, lumbago, other pains (headache, angina and the like), the pain is relieved within 10-15 minutes generally after the injection, and the injection can last for 2-4 hours.
Linalool (Linalool) is also called Linalool, galois, Linalool and the like, has a strong and sweet dark green smell, is like rosewood fragrance, is more like green tea fragrance just coming out of a furnace, has the flower fragrance of lilac, lily and roses, also has the fragrance of costus root and fruit, has soft fragrance, is slightly raised and fully developed, is not very persistent, and can eliminate indoor uncomfortable smell. Linalool is terpene compound, and has good antibacterial activity on Escherichia coli, Proteus, Enterobacter enteritidis, Staphylococcus, Saccharomyces cerevisiae, white coccoid, Aspergillus niger, agar, etc. The application of linalool to white mice in experimental models has been reported since ancient times in foreign folks, and the results of the drug administration of linalool to white mice indicate that the central nervous system including sleep, anticonvulsant and hypothermia has the phenomenon of dose-dependent increase. In addition, linalool vapor affects the brain through olfaction, has significant anxiolytic properties, and unlike anxiolytic drugs, linalool acts systemically. Linalool has a stabilizing effect on foam, and a small amount of linalool is added to a spray-type aqueous cleanser containing a nonionic or anionic surfactant, so that the stability of foam can be effectively increased.
Linalool and the content thereof are very key to the bath lotion to play roles of sweating and relieving exterior syndrome (fever, convulsion and bacterial infection are western medicine symptoms corresponding to the wind-cold type common cold in traditional Chinese medicine), and the stabilizing effect on foam is also beneficial to the body feeling of the bath lotion during bathing.
The baths prepared in examples 1 to 11 were used, wherein the linalool content is shown in table 5 below.
TABLE 5 linalool content (%) -of baths obtained by different preparation methods
Examples Linalool content Examples Linalool content Examples Linalool content
1 0.51 4 0.39 7 0.67
2 0.52 5 0.48 8 0.50
3 0.40 6 0.43 9 0.41
10 0.49 11 0.84
Example 17: content of limonene in bath liquid
The Chinese prickly ash has the functions of warming the middle-jiao and relieving pain; it has the actions of removing dampness, stopping diarrhea, killing parasites and relieving itching, and is mainly indicated for abdominal cold pain, ascarid abdominal pain, vomiting and diarrhea, cough and cough due to lung cold, toothache due to dental caries, pruritus vulvae, leukorrhagia, eczema and skin pruritus due to deficiency-cold of spleen and stomach. The main component of the volatile oil in the pericarpium zanthoxyli is limonene (limonene) accounting for 25.10 percent of the total oil amount, and the volatile oil in the pericarpium zanthoxyli accounts for 7.30 percent. From the above disclosure, limonene and its content are very important for bath liquid to exert the effects of inducing sweat and relieving exterior syndrome (cough and asthma are western medicine symptoms corresponding to the wind-cold type common cold in traditional Chinese medicine).
The baths prepared in examples 1-11 were used, wherein the limonene content is shown in table 6 below.
TABLE 6 limonene content (%)
Examples Limonene content Examples Limonene content Examples Limonene content
1 0.01 4 0.03 7 0.04
2 0.02 5 0.08 8 0.05
3 0.10 6 0.03 9 0.01
10 0.04 11 0.24
Example 18: the bath lotion contains cinnamaldehyde and benzyl benzaldehyde
According to the scheme of the invention, cassia twig is used in the formula of the Jiangyao bath lotion. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation. The cassia twig alcohol extract can inhibit escherichia coli, bacillus subtilis and staphylococcus aureus in vitro, and the effective concentration is 25 mg/ml or below; it also has inhibitory effect on Staphylococcus albus, Shigella shigella, typhoid and paratyphoid Bacillus, pneumococcus, aerobacter, proteus, Bacillus anthracis, Salmonella enteritidis, Vibrio cholerae, etc. (plate holing method). Ramulus Cinnamomi contains volatile oil 0.69%, and the main components of the oil are cinnamaldehyde 64.75%, and benzyl benzoate.
Cinnamaldehyde is colorless or yellowish liquid, is insoluble in water, glycerol and petroleum alcohol, is soluble in organic solvents such as acetone, ethanol, dichloromethane, chloroform and carbon tetrachloride, and has analgesic, antipyretic, antibacterial and antiviral effects (especially to influenza virus). Can be externally used in massage liquid and cosmetic products to dissipate blood stasis, promote blood circulation, warm skin and compact skin tissues, and can be externally used for massage to make limbs and body smooth and improve water retention; can be used in traumatic injury external preparations such as safflower oil, menthocamphorate, and activating collateral flow oil, and has effects of activating collateral flow of tendons and bones, dispelling blood stasis, tranquilizing mind, relieving pain, relieving fever, relieving convulsion, regulating central nervous system, and increasing leukocyte and platelet count; also has strong antifungal effect, and has effect in inhibiting dermatophytes. Benzyl benzoate can be used as fragrance fixative, also called fragrance preserving agent, and can make the fragrance components uniformly volatilize, prevent rapid evaporation, and make the fragrance of the essence more durable.
From the above disclosure, cinnamaldehyde and its content are critical to the bath lotion's effects of inducing sweat and relieving exterior syndrome (antibacterial, antiviral, promoting blood circulation, relieving fever and pain), while benzyl benzoate can make various aromatic components in bath lotion more persistent, which is beneficial to bath lotion's effectiveness.
The baths prepared in examples 1 to 11 were used, in which the cinnamaldehyde content was as shown in Table 7 below.
TABLE 7 cinnamic aldehyde content (%)
Examples Cinnamic aldehyde content Examples Cinnamic aldehyde content Examples Cinnamic aldehyde content
1 0.31 4 0.39 7 0.37
2 0.22 5 0.28 8 0.38
3 0.24 6 0.40 9 0.41
10 0.19 11 0.54
The baths prepared in examples 1-11 were used, wherein the benzyl benzoate content is shown in table 8 below.
TABLE 8 benzyl benzoate content (%)
Figure BDA0003033033560000131
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (5)

1. A preparation method of a Jiang Yao bath composition for expelling wind and clearing away cold and inducing sweat to relieve exterior syndrome is characterized in that the Jiang Yao bath composition is extracted and prepared by the following method:
(1) weighing the medicinal materials according to the components respectively, and crushing the medicinal materials;
(2) mixing the crushed cassia twig, the dried ginger, the caulis spatholobi, the Chinese honeylocust fruit and the soapberry, adding water, extracting at 60-80 ℃ for 5-8 hours, filtering an extracting solution, and concentrating to obtain a first concentrated solution with the volume being 1-3 times of the mass of the medicinal materials for later use;
(3) mixing the crushed folium artemisiae argyi, the citronella and the pepper, adding an ethanol water solution with the volume fraction of 10-40%, performing reflux extraction at the temperature of 60-80 ℃ for 2-4 hours, filtering an extracting solution, recovering ethanol until no ethanol smell exists, and concentrating to the volume of 1-3 times of the mass of the medicinal materials to obtain a second concentrated solution for later use;
(4) mixing the first concentrated solution and the second concentrated solution, filtering, bottling, and sealing;
the Jiangyao bath composition is prepared from 40-60g of cassia twig, 25-45g of dried ginger, 10-15g of suberect spatholobus stem, 30-50g of folium artemisiae argyi, 20-30g of Chinese honeylocust fruit, 10-20g of Chinese soapberry, 50-80g of citronella and 10-20g of pepper;
in the step (1), the crushing is to crush the medicinal materials into particles which can pass through a standard sieve of 10 meshes;
in the step (2), adding water according to the mass-to-volume ratio of 1: 5-8;
in the step (3), an ethanol water solution is added according to the mass-to-volume ratio of 1: 2-5.
2. The preparation method according to claim 1, wherein the Jiangyao bath composition is prepared from the following raw materials of 40g of cassia twig, 25g of dried ginger, 10g of caulis spatholobi, 30g of folium artemisiae argyi, 20g of saponin, 10g of Chinese soapberry, 50g of citronella and 10g of pepper.
3. A Jiangyao bath composition capable of expelling wind and clearing away cold, inducing sweat and relieving exterior syndrome, which is prepared by the preparation method of any one of claims 1 to 2.
4. The use of the Yao Yuanjian bath composition of claim 3 in the preparation of a medicament for treating exogenous fever.
5. A Yao-Yunjiang bath lotion comprising the Yao-Yunjiang bath composition according to claim 3.
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