CN105535196A - Medicine composition for treating rhinitis and preparation method thereof - Google Patents

Medicine composition for treating rhinitis and preparation method thereof Download PDF

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Publication number
CN105535196A
CN105535196A CN201610021810.4A CN201610021810A CN105535196A CN 105535196 A CN105535196 A CN 105535196A CN 201610021810 A CN201610021810 A CN 201610021810A CN 105535196 A CN105535196 A CN 105535196A
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parts
radix
flos
rhinitis
pharmaceutical composition
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赵玉国
丁勇
王树青
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Dalian Dent Biotechnology Co Ltd
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Dalian Dent Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention discloses a medicine composition for treating rhinitis and a preparation method thereof. The medicine composition is prepared from grapefruit peel, honeysuckle, scutellaria baicalensis, magnolia flower, radix angelicae dahurioae, Chinese parsnip root, radix bupleuri, the root of kudzu vine, mint leaves, folium eucalypti, chrysanthemum, salt, xylitol and water or water extract. The medicine composition has the effects of achieving broad-spectrum sterilization, diminishing inflammation, relieving pain and itching, enhancing immunity, improving microcirculation and having no side effect or dependency, has the good effects on treating acute or chronic rhinitis, allergic rhinitis, nasosinusitis and paranasal sinusitis, is convenient and fast to use and high in cure rate and enables rhinitis not to relapse easily.

Description

A kind of pharmaceutical composition being used for the treatment of rhinitis and preparation method thereof
Technical field
The invention belongs to health product, medicine field, relate to a kind of pharmaceutical composition for the treatment of rhinitis and preparation method thereof.
Background technology
Enter autumn and winter season or the beginning of spring, people are easy to suffer from rhinitis.Rhinitis is the inflammation of nasal membrane and submucous tissue, comprises acute and chronic nasal sinusitis, nasal sinusitis, rhinitis, allergic rhinitis etc., shows as hyperemia or edema.Often there is rhinocnesmus of having a stuffy nose in patient, sneeze, flows clear nasal mucus, and olfactory sensation declines or disappears, dizzy, the symptoms such as headache.Rhinitis not only affects nose, throat and eyes, also can affect sleep, audition, even inappetence, easily tired, hypomnesis etc.Have a strong impact on people's orthobiosis and work.
Have Chinese patent medicine and the Western medicine of a lot for the treatment of rhinitis in prior art, dosage form mostly is the oral formulations such as tablet, capsule, powder, and be not that medicine is expensive, use inconvenience exactly, key is cured the symptoms, not the disease, and controls effect single, Relapse rate.
Yet there are no and share the relevant report for the treatment of rhinitis about grapefruit peel, Flos Lonicerae, Radix Scutellariae, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, mentha leave, Eucalyptus globulus Labill leaf, Flos Chrysanthemi, Sal, xylitol.
Summary of the invention
One is the object of the present invention is to provide to treat drug for treating rhinitis compositions, there is broad-spectrum sterilization, antiinflammatory, pain relieving, antipruritic, enhancing immunity, improve microcirculation, have no side effect, no dependence, good effect is had to treatment acute and chronic rhinitis, allergic rhinitis, sinusitis, nasal sinusitis, convenient, fast, cure rate is high, not easily recur.
Concrete technical scheme is: a kind of pharmaceutical composition being used for the treatment of rhinitis, comprises following raw material or its extract: grapefruit peel, Flos Lonicerae, Radix Scutellariae, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, mentha leave, Eucalyptus globulus Labill leaf, Flos Chrysanthemi.
As preferred technical scheme, described extract is water extract or alcohol extract.
As preferred technical scheme, described pharmaceutical composition also comprises Sal, xylitol.
As preferred technical scheme, described pharmaceutical composition comprises the raw material of following weight ratio: grapefruit peel 1-20 part, Flos Lonicerae 200-600 part, Radix Scutellariae 100-200 part, Flos Chrysanthemi 100-300 part, Flos Magnoliae 100-300 part, Radix Angelicae Dahuricae 100-300 part, Radix Saposhnikoviae 100-300 part, Radix Bupleuri 200-600 part, Radix Puerariae 100-300 part, mentha leave 100-300 part, Eucalyptus globulus Labill leaf 100-300 part, Sal 1-10 part, xylitol 10-20 part, purified water 100 ~ 200 parts.
Be preferably: grapefruit peel 10 parts, Flos Lonicerae 500 parts, Radix Scutellariae 150 parts, Flos Chrysanthemi 240 parts, Flos Magnoliae 240 parts, the Radix Angelicae Dahuricae 240 parts, Radix Saposhnikoviae 240 parts, Radix Bupleuri 300 parts, Radix Puerariae 240 parts, mentha leave 240 parts, Eucalyptus globulus Labill leaf 240 parts, Sal 8 parts, xylitol 15 parts, purified water 150 parts.
Another order of the present invention is the preparation method providing above-mentioned treatment drug for treating rhinitis compositions, grapefruit peel is pulverized, with the 70-80% ethanol of 20 times of weight portions, ultrasonic temperature 35-40 DEG C, ultrasonic power 100-200W, supersound extraction 1-3 time, each 20-30min, filter extracting solution, by filtrate recycling ethanol, obtain concentrated solution;
After Flos Chrysanthemi, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae water temperature are soaked 1 hour, carry out decoction after 1 hour, filter, add Flos Lonicerae and Radix Scutellariae again after material slag adds water, then decoct 40 minutes, filter, merging filtrate, it is 1.17 that filtrate is concentrated into relative density, adds ethanol, ethanol content is made to reach 65-70%, stir well, placement is spent the night, and filters, reclaim ethanol and be concentrated into appropriate, spraying dry obtains extractum powder;
Mentha leave, Eucalyptus globulus Labill leaf were extracted volatile oil with steam distillation 1-3 hour;
Mix described concentrated solution, extractum powder and volatile oil.
As preferred technical scheme, by described concentrated solution, extractum powder, volatile oil mixing, add purified water and be stirred and heated to 60 DEG C, add xylitol, Sal successively, stir 15-20 minute, be cooled to 30-40 DEG C, filtration, fill.
Using method: every day, 3-4 use was sprayed at nasal cavity.
The beneficial effect of pharmaceutical composition provided by the invention is:
Functional component is grapefruit peel, Flos Lonicerae, Radix Scutellariae, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, mentha leave, Eucalyptus globulus Labill leaf, Flos Chrysanthemi, Sal, and xylitol is unique sweeting agent.There is broad-spectrum sterilization, antiinflammatory, pain relieving, antipruritic, enhancing immunity, improve microcirculation, have no side effect, no dependence, good effect is had to treatment acute and chronic rhinitis, allergic rhinitis, sinusitis, nasal sinusitis, convenient, fast, cure rate is high, not easily recur, be easy to be accepted by patient.
Grapefruit has another name called Citrua paradiai, is rutaceae.Grapefruit fruit soft and succulency, unique flavor, at present main in order to eat raw, juice processed, canned food etc., and peel is usually dropped, both not environmentally uneconomical.It is reported, grapefruit is containing abundant flavone compound, in its peel, flavones ingredient is the highest, and the naringin in its flavonoid has many-sided biological activity, comprise anti-inflammatory and antalgic, antibacterial, improve microcirculation, have certain inhibitory action for anaphylaxis material.Naringin is the very potential high-efficiency broad spectrum bacteriostatic compound of one, just can obtain obvious bactericidal effect when extremely low concentration, and it can suppress Gram-negative and gram-positive bacterium and fungus, suppresses virus and parasite.Naringin oral absorption is poor, major part by the metabolism of intestinal microbial population de-glycosylation be after naringenin through intestinal wall with the mode absorbed into serum of Passive diffusion.
Flos Lonicerae: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis, containing chlorogenic acid, isochlorogenic acid etc., sweet in the mouth, cold in nature.Antibacterial, the effects such as antiinflammatory, detoxifies, antipyretic.Shennong's Herbal carries: " Flos Lonicerae sweet in the mouth cold in nature, has heat-clearing and toxic substances removing, cure mainly affection due to external wind and heat, pestilence from the beginning of, red and swollen heat pain, passing stool with blood and pus " etc.
Radix Scutellariae: be labiate, be used as medicine with root.Bitter in the mouth, cold in nature.Antibacterial, antiinflammatory, heat clearing and damp drying, eliminating fire and detoxication.It is antibacterial better than Rhizoma Coptidis, and does not develop immunity to drugs.
Flos Chrysanthemi: containing compositions such as stachydrine, choline, glycosides, be especially rich in volatile oil.Property sweet, be slightly cold, there is loose wind heat, suppressing the hyperactive liver improving eyesight, disappear and cough effect of pain relieving, be used for the treatment of the disease Be very effective such as headache dizzy, conjunctival congestion and swelling pain, anemopyretic cold, cough, also there is effect of refreshment.Modern pharmacological research shows, Flos Chrysanthemi has antibacterial, antiviral, antiinflammatory, anti-ageing multiple pharmacologically active of waiting for a long time.
Flos Magnoliae: be the alabastrum of Magnoliacea plant Flos Magnoliae, containing volatile oil and alkaloid.Acrid in the mouth, warm in nature.Gui Jing, lung, stomach footpath, have dispersing wind and cold, and effect of clearing the nasal passage, is applicable to headche due to wind-cold, nasal obstruction, nasal sinusitis, the diseases such as turbid nasal discharge.Modern Chinese medicine with it be equipped with the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri is used for treating acute and chronic rhinitis, allergic rhinitis, sinusitis, nasal sinusitis.Add in the dispelling wind and heat pathogens medicines such as Herba Menthae, Flos Lonicerae, Flos Chrysanthemi, the power of clearing the nasal passage, loose ailment said due to cold or exposure can be strengthened.
The Radix Angelicae Dahuricae: warm in nature, bitter in the mouth, dispels the wind, dampness, detumescence, pain relieving.
Radix Saposhnikoviae: acrid-sweet flavor, slightly warm in nature, inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Radix Bupleuri: containing saikoside, volatile oil, fatty acid and polysaccharide etc.Bitter in the mouth, cold nature, reconciling superficies and interior, depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, loose effect of fire.Contained by it, volatile oil has refrigeration function, and saponin has anti-inflammatory efficacy.
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Having induces sweat brings down a fever, the multiple efficacies such as to promote the production of body fluid, and can control that fever caused by exogenous pathogens is had a headache, quenched one's thirst, the various diseases such as measles without adequate eruption, heat rash.
Mentha leave: containing Mentholum, acrid in the mouth, cool in nature.Its function is chafe mucosa mainly, and while antipruritic, antiinflammatory, pain relieving, local has cool feeling.Be applicable to treat cold anemopyretic, mouth and nose are dry, headache nasal obstruction, many sneeze watery nasal discharge.
Eucalyptus globulus Labill leaf: the Eucalyptus Globulus oil obtained through vapor distillation, has special fragrance, acrid in the mouth, cool.There are wind-expelling pain-stopping, antipruritic, anti-inflammatory efficacy, same with playing collaborative effect with Mentholum.It has stronger broad-spectrum antibacterial action in addition, all has good fungistatic effect to golden yellow and Staphylococcus albus, streptococcus, tubercule bacillus etc.With grapefruit peel extract conbined usage, expand bactericidal range further and strengthen bactericidal effect.
The main component of Sal is sodium chloride, has heat clearing away, removing toxic substances, antiinflammatory, itching-relieving action.By using nasal spray, the soil such as the anaphylactogen of nasal cavity, virus, rheuminess thing can be removed by saline, alleviate nasal membrane edema, recover the functions of expelling toxin of nasal cavity self, thus eliminate Rhinitis Symptoms.It has good effect to allergic rhinitis, chronic rhinitis and chronic sinusitis.
Detailed description of the invention
Following non-limiting example can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.
Embodiment 1
Prescription forms: by ratio of weight and the number of copies, grapefruit peel 10 parts, Flos Lonicerae 500 parts, Radix Scutellariae 150 parts, Flos Chrysanthemi 240 parts, Flos Magnoliae 240 parts, the Radix Angelicae Dahuricae 240 parts, Radix Saposhnikoviae 240 parts, Radix Bupleuri 300 parts, Radix Puerariae 240 parts, mentha leave 240 parts, Eucalyptus globulus Labill leaf 240 parts, Sal 8 parts, xylitol 15 parts, purified water 150 parts.
Preparation method:
1, grapefruit peel is pulverized, with the 70-80% ethanol of 20 times of weight portions, ultrasonic temperature 35-40 DEG C, ultrasonic power 100-200W, supersound extraction 1-3 time, each 20-30min, filters extracting solution, by filtrate recycling ethanol, obtains concentrated solution;
2, after Flos Chrysanthemi, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae water temperature being soaked 1 hour, carry out decoction after 1 hour, filter, add Flos Lonicerae and Radix Scutellariae again after material slag adds water, then decoct 40 minutes, filter, merging filtrate, it is 1.17 that filtrate is concentrated into relative density, adds ethanol, ethanol content is made to reach 65-70%, stir well, placement is spent the night, and filters, reclaim ethanol and be concentrated into appropriate, spraying dry obtains extractum powder;
3, mentha leave, Eucalyptus globulus Labill leaf were extracted volatile oil with steam distillation 1-3 hour;
4, step (1) concentrated solution, step (2) extractum powder, step (3) volatile oil are mixed and add in material-compound tank, add purified water and be constantly stirred and heated to 60 DEG C, add xylitol, Sal successively, continuous stirring 15-20 minute, obtains mixing material;
5, step (4) mixing material is cooled to 30-40 DEG C, is made by plate filter filtration, fill.
Using method: every day, 3-4 use was sprayed at nasal cavity.
Model case:
Example 1 week certain, man, 41 years old, people from Dalian, frequent sneeze, rhinorrhea, and with headache, in March, 2015, use this spray, daily 3-4 time.Within 10 days, cure, do not recur so far.
Example 2 Wang, man, 45 years old, people from Dalian, allergic rhinitis, symptom was rhinocnesmus, sneeze, rhinorrhea, and with ophthalmic pruritus, in December, 2014, uses this spray, daily 3-4 time.Eat the product that genus that is pungent, peppery, fried, stir-fry is hot during advising its medication less, avoid the marine products such as the easy Induced by Stimulation inflammation such as seafood and fish and shrimp, within 7 days, take a turn for the better.
Example 3 Zhang, female, 51 years old, people from Lvshun, Liaoning, sinusitis was secondary nasal sinuses suppurative inflammation after nasal cavity infects.Symptom is nasal obstruction, flows dense nasal mucus, and with headache, in JIUYUE, 2015, uses this spray, daily 3-4 time.Headache in 1 day disappears, and within three weeks, cures, does not recur so far.

Claims (7)

1. be used for the treatment of a pharmaceutical composition for rhinitis, comprise following raw material or its extract: grapefruit peel, Flos Lonicerae, Radix Scutellariae, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, mentha leave, Eucalyptus globulus Labill leaf, Flos Chrysanthemi.
2. pharmaceutical composition according to claim 1, is characterized in that, described extract is water extract or alcohol extract.
3. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises Sal, xylitol.
4. pharmaceutical composition according to claim 1 and 2, it is characterized in that, comprise the raw material of following weight ratio: grapefruit peel 1-20 part, Flos Lonicerae 200-600 part, Radix Scutellariae 100-200 part, Flos Chrysanthemi 100-300 part, Flos Magnoliae 100-300 part, Radix Angelicae Dahuricae 100-300 part, Radix Saposhnikoviae 100-300 part, Radix Bupleuri 200-600 part, Radix Puerariae 100-300 part, mentha leave 100-300 part, Eucalyptus globulus Labill leaf 100-300 part, Sal 1-10 part, xylitol 10-20 part, purified water 100 ~ 200 parts.
5. pharmaceutical composition according to claim 1 and 2, it is characterized in that, comprise the raw material of following weight ratio: grapefruit peel 10 parts, Flos Lonicerae 500 parts, Radix Scutellariae 150 parts, Flos Chrysanthemi 240 parts, Flos Magnoliae 240 parts, the Radix Angelicae Dahuricae 240 parts, Radix Saposhnikoviae 240 parts, Radix Bupleuri 300 parts, Radix Puerariae 240 parts, mentha leave 240 parts, Eucalyptus globulus Labill leaf 240 parts, Sal 8 parts, xylitol 15 parts, purified water 150 parts.
6. prepare a method for Chinese medicine composition described in claim 1 or 2 or 3, it is characterized in that,
(1) grapefruit peel is pulverized, with the 70-80% ethanol of 20 times of weight portions, ultrasonic temperature 35-40 DEG C, ultrasonic power 100-200W, supersound extraction 1-3 time, each 20-30min, filters extracting solution, by filtrate recycling ethanol, obtains concentrated solution;
(2) after Flos Chrysanthemi, Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae water temperature being soaked 1 hour, carry out decoction after 1 hour, filter, add Flos Lonicerae and Radix Scutellariae again after material slag adds water, then decoct 40 minutes, filter, merging filtrate, it is 1.17 that filtrate is concentrated into relative density, adds ethanol, ethanol content is made to reach 65-70%, stir well, placement is spent the night, and filters, reclaim ethanol and be concentrated into appropriate, spraying dry obtains extractum powder;
(3) mentha leave, Eucalyptus globulus Labill leaf were extracted volatile oil with steam distillation 1-3 hour;
(4) blend step (1) gained concentrated solution, step (2) gained extractum powder, step (3) gained volatile oil.
7. method according to claim 6, is characterized in that, by described concentrated solution, extractum powder, volatile oil mixing, adds purified water and is stirred and heated to 60 DEG C, add xylitol, Sal successively, stir 15-20 minute, be cooled to 30-40 DEG C, filtration, fill.
CN201610021810.4A 2016-01-13 2016-01-13 Medicine composition for treating rhinitis and preparation method thereof Pending CN105535196A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846981A (en) * 2019-04-03 2019-06-07 深圳市远光宙科技有限公司 A kind of external application nose cream with Reduce allergy Rhinitis Symptoms
WO2020142054A3 (en) * 2019-01-03 2020-08-06 Helvacizade Gida İlaç Ki̇mya Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Nasal spray formulation
CN112057609A (en) * 2020-09-28 2020-12-11 浙江丽能生物医药科技有限公司 MOA lysozyme nasal spray preparation and preparation method thereof
US11541095B2 (en) 2019-04-03 2023-01-03 Shenzhen Yuanguangzhou Technology Co., Ltd. Nasal balm for relieving allergic rhinitis symptoms

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020142054A3 (en) * 2019-01-03 2020-08-06 Helvacizade Gida İlaç Ki̇mya Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Nasal spray formulation
CN109846981A (en) * 2019-04-03 2019-06-07 深圳市远光宙科技有限公司 A kind of external application nose cream with Reduce allergy Rhinitis Symptoms
CN109846981B (en) * 2019-04-03 2021-07-27 深圳市远光宙科技有限公司 A topical nasal paste for relieving allergic rhinitis
CN113274445A (en) * 2019-04-03 2021-08-20 深圳市远光宙科技有限公司 Preparation method of external nasal paste for relieving allergic rhinitis symptoms
CN113274445B (en) * 2019-04-03 2022-02-01 深圳市远光宙科技有限公司 Preparation method of external nasal paste for relieving allergic rhinitis symptoms
US11541095B2 (en) 2019-04-03 2023-01-03 Shenzhen Yuanguangzhou Technology Co., Ltd. Nasal balm for relieving allergic rhinitis symptoms
CN112057609A (en) * 2020-09-28 2020-12-11 浙江丽能生物医药科技有限公司 MOA lysozyme nasal spray preparation and preparation method thereof

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Application publication date: 20160504