CN103656397A - Compound medicine for treating chronic pharyngitis - Google Patents

Abstract

The invention relates to a compound medicine for treating chronic pharyngitis and a preparation method thereof. The invention is characterized in that the medicine is prepared from selected Chinese medicinal herb essence components with reasonable compatibility by a special technique. The medicine is prepared from pure Chinese medicinal herb components and is free of any chemical component. The Chinese medicinal herb components are strictly screened and proportioned through the experiments, so the medicine has favorable compound effect. The medicine is prepared by a special technique, has the advantages of stable quality and no toxic or side effect on the human body, is convenient to take, and is used for recurrent chronic simple pharyngitis, chronic hypertrophic pharyngitis, atrophic pharyngitis, pharyngitis sicca, chronic allergic pharyngitis, chronic reflux pharyngitis and many other upper respiratory tract pathological changes near the pharyngeal portion.

Description

A kind of chronic pharyngitis compound medicines for the treatment of

technical fieldthe present invention relates to a kind of chronic pharyngitis compound medicines and preparation method thereof for the treatment of.The Chinese herbal medicine composition that it is characterized in that selected reasonable compatibility.The active ingredient of formula is Fructus Nandinae Domesticae, Lasiosphaera Seu Calvatia, Semen Armeniacae Amarum, Fructus Canarii, the Radix Stemonae, Rhizoma Belamcandae, Radix Sophorae Tonkinensis, Fructus Arctii, Semen Oroxyli, Calyx Seu Fructus Physalis, Radix Glycyrrhizae, the present invention is pure medicinal herb components, not containing any chemical composition, through testing strict screening compatibility, compound recipe action effect is good, through special process configuration, form, steady quality, be convenient to take, human body is had no side effect, be applicable to the treatment chronic simple pharyngitis of outbreak repeatedly, chronic hypertrophic pharyngitis, atrophic and pharyngitis sicca, chronic anaphylaxis pharyngitis, the near upper respiratory tract pathological changes of multiple pharyngeal neck such as chronic regurgitation pharyngitis.

background technologychronic pharyngitis is for swallowing under mucosa, mucosa and adenoid chronic inflammatory disease.Diffusivity pharyngeal inflammation is often a part for upper respiratory tract chronic inflammatory disease, and limitation pharyngeal inflammation mostly is pharynx lymphoid tissue inflammation.Primary disease is common in clinical, and the course of disease is long, and symptom is outbreak repeatedly easily.Motherland's medical science is prevented and treated chronic pharyngitis, sets forth one's views greatly mainly with deficiency of YIN phlegm-fire, and medication be take relieving sore-throat by clearing away heat as main, assorted with methods such as yin nourishing expectorants, as < < Treatise on Febrile Diseases > > have " SHAO YIN syndrome, diarrhea, pharyngalgia; ' and fullness in the chest; vexed, Corii Sus domestica soup master it ", " SHAO YIN syndrome, two or three days; pharyngalgia person, can with glycyrrhiza decoction; Not poor, with Radix Platycodonis decoction ", " SHAO YIN syndrome, throat injury, raw skin ulcer, unable to speak, aphonia person, Bitters soup master it ", " SHAO YIN syndrome, pain in pharynx, the loose and soup master of the Rhizoma Pinelliae it " discussion.To the Qing Dynasty, comprehensive each family of Lin Peiqin says, still without large discrepancy, the opinion through > > in < < of take as initial is guiding principle: " through cloud: monoyin and monoyang knot; the sore throat of meaning; be related to throat with monarch's phase two fiery passages through which vital energy circulates ", " sore throat, attacks in wind-phlegm stagnated fire; Tonsillitis, wine and women-sensual pursuits is hot and suffocating and give birth to; Membranous pharyngitis, hyperactivity of deficient fire ".Qing Luo state is just except from the deficiency of YIN is seted forth one's views, also set forth yang deficiency sore throat: " have again fire empty under, and refusing yang is in upper, the fire of this unrooted, be true sympotoms caused by cold factors in kidney also, warming and recuperating the gate of life, Bai-Wei-Dihuang soup master it, must abide by the interior method through > > contrary treatment of < <, can't be with cold and cool to urge its danger ear " Zhang Jingyue proposes that " sun is normal not enough, cloudy this nothing left ", " deficiency of QI producing cold ", think in deficient sore throat, also have fire empty under, sun floats on upper refusing yang card, therefore decoct with reason the moon, large complement is decocted etc. and to be filled up Kidney-Yin, replenishing vital QI with drugs of warm nature yang-energy and healing, and point out: the overstrain person of ignoring is many, and one-tenth is deficient, the teenager person of indulging in drinking is many, and one-tenth is deficient, disease wrong treatment and losing in conditioning person, many one-tenth is deficient after being ill.With regard to its pathologic feature, mainly causing the virtual loss of yang-energy. yang deficiency is lost and is defended the duty of outer replenishing vital QI with drugs of warm nature and the obstacle that causes gasifying, and sun is not changed the moon, and throat loses supports; Spleen loses warming YANG, failure of the spleen to transport and transform, spleen-QI sinking, fire is offed normal mutually, multiple imapirment of the spleen and stomach, weary the exhausting of QI and blood and cause lung stomach or liver lung qi stagnant, the strongly fragrant resistance of venation, nutrient blood temperature fortune is lost and is weighed.The body resistance strengthening and constitution consolidating is focused in Chinese traditional treatment, by reinforcing body resistance, suppresses pathogen, improves the resistance against diseases of health, reaches the process that development occurs effective inhibition chronic pharyngitis.Treatment chronic pharyngitis compound medicines providing a kind of pure natural plant essence extraction and preparation method thereof is provided the object of the invention, has relieving cough and asthma, and damp eliminating is reduced phlegm, replenishing YIN and removing heat, the effect of eliminating pathogenic factor for supporting vital QI.Be applicable to the various various symptoms that cause due to chronic pharyngitis, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions are difficult for bringing up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, because pharynx rear wall adheres to because pharyngeal chronic inflammatory disease causes compared with thick secretions conventionally, and because nose, nasal sinuses, nasopharynx pathological changes cause mouth breathing at night, while rising, there is irritable cough the morning of being everlasting and feel sick.Pharyngeal secretions is few and be difficult for expectoration person and often show as habitually dry cough and the action of coughing up phlegm of clearing one's throat, if firmly cough or clear one's throat, can cause pharyngeal mucosa hemorrhage, causes and in secretions, is with blood etc.

summary of the inventionthe invention is characterized in a kind of chronic pharyngitis compound medicines and preparation method thereof for the treatment of is provided, utilize the mutual synergism of active component of multiple Chinese herbal medicine essence, have relieving cough and asthma, damp eliminating is reduced phlegm, replenishing YIN and removing heat, the effect of eliminating pathogenic factor for supporting vital QI.

Formula of the present invention following (component and percentage by weight % thereof): Fructus Nandinae Domesticae 20.0-30.0, Lasiosphaera Seu Calvatia 12.0-20.0, Semen Armeniacae Amarum 9.0-15.0, Fructus Canarii 12.0-20.0, Radix Stemonae 5.0-12.0, Rhizoma Belamcandae 6.0-12.0, Radix Sophorae Tonkinensis 3.0-9.0, Fructus Arctii 15.0-30.0, Semen Oroxyli 4.0-12.0, Calyx Seu Fructus Physalis 6.0-15.0, Radix Glycyrrhizae 2.0-6.0.

Fructus Nandinae Domesticae is astringed the lung, cough-relieving, liver heat removing, improving eyesight.Control chronic cough, pant, pertussis, malaria, primary sore is festered.Pharmacological action: 1, the effect to smooth muscle: 1-hydroxy-2-methoxy-9,10-methylenedioxyaporphine. can make Cavia porcellus intestinal tube tensity in place rise, but contrary to the effect of intestine in vitro; To isolated rabbit uterus excited, paralysis in a large number in a small amount.Nandinine is in vitro rabbit intestinal and uterus, dog intestinal tube, be all in a small amount excited, suppress in a large number; To rabbit intestinal in place and uterus, rarely seen excitation, intensity dosage and increasing; This application point is aspect vegetative nerve tip and muscle two.

Lasiosphaera Seu Calvatia pharmacological action: 1, antibacterial action: in vitro tests, lasiosphaera fenzlii Reics decoct has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae, and minority pathomycete is also had to inhibitory action.In decoct, containing a large amount of pigments, through with after activated carbon decolorizing, antibacterial action subtracts greatly.The squeezing juice of the new fresh sporophore of dust gill fungus, to animal injection, can poison blood capillary, causes visceral hemorrhage.2, laryngopharynx swelling and pain, can not swallow thing: with Lasiosphaera Seu Calvatia one minute, one of Periostracum Serpentis, water as end, cotton is wrapped up in a money, containing pharynx.

Semen Armeniacae Amarum pharmacological action: contain amygdaloside in Semen Armeniacae Amarum, amygdaloside can be hydrolyzed by enteric microorganism enzyme or the contained emulsin of Semen Armeniacae Amarum itself in vivo, produce micro-hydrocyanic acid and benzaldehyde, respiratory center is had to inhibitory action, reach antitussive, antiasthmatic effect.The < < book on Chinese herbal medicine > > that looks for the truth records " Semen Armeniacae Amarum, the energy of existing dispersing wind-cold have the therapeutic method to keep the adverse QI flowing downwards to remove the power of breathing heavily again ".Kind relieving cough and resolving phlegm and relievining asthma, to main disease cough, the abundant expectoration of lung system, pant and have strong specific aim, therefore doctor is that medication is used using it as lung at all times, internal injury diseases caused by exogenous pathogenic factor no matter, new sick obstinate disease, all lungs that relate to, multiplex it.Adopt the test of guinea pig in vitro organ, almond water extracting solution can reduce the sensitivity that organ irritates ammonia, to antihistamine, acetylcholine, the excitation of barium chloride to tracheal smooth muscle, has obvious antitussive action.Semen Armeniacae Amarum is because promoting the synthetic pulmonary respiratory function that is conducive to of pulmonary surfactant (PS), and Semen Armeniacae Amarum can not only promote the synthetic of PS, and can improve the physiology and biochemistry index of various relevant lungs.

Fructus Canarii pharmacological action: the volatile oil of Fructus Canarii leaf has antibacterial action in vitro.The warm macerating agent that rabbit gavages fruit has phlegm-dispelling functions, and to mice, without antitussive action, in vitro guinea pig bronchial perfusion experiment shows the effect of adiastole bronchus, to artificial fever rabbit without refrigeration function.Anesthetized rabbit gavages 1～1.25 g/kg of preserved material, in 2 hours, electrocardiogram is had no significant effect.

Radix Stemonae pharmacological action: 1, antitussive, phlegm-dispelling functions: Stemona alkaloids can reduce the irritability of animal breath maincenter, suppress coughre flex and the effect of tool antitussive.Also have report to point out, Radix Stemonae decoct gavages, the cough causing inject the right pleura chamber of cat with 1% iodine liquid; Stemona alkaloids extracting solution 10ml/kg lumbar injection, to draw the mouse cough that the method for coughing causes with sulfur dioxide, all without antitussive effect.100% Stemona alkaloids extracting solution 2ml/kg gavages to rabbit, without phlegm-dispelling functions.2, the effect to bronchial smooth muscle: 100% Stemona alkaloids extracting solution 0.2ml has relexation to the caused in vitro guinea pig bronchial smooth muscle spasm of histamine, and its action intensity is similar to aminophylline, but compared with slowly and lastingly.

Rhizoma Belamcandae pharmacological action: 1, resisting pathogenic microbes effect: in vitro, Rhizoma Belamcandae decoct or preserved material have stronger antibacterial action to common pathogenic dermatophytosis; In vitro, the concentration of 1:20, to some virus in diseases caused by exogenous pathogenic factor and throat illness, also has the effect that suppresses or delay its morbidity.2, antiinflammatory action: shekanin and tectorigenin have the effect of antihyaluronidase, and do not blocked by aminothiopropionic acid in test tube.Hyaluronidase edema to rat has inhibitory action, but can not suppress chondrus ocellatus Holmes colloidality edema. and the ascites that rat is caused because of lumbar injection chlormethine is oozed out also inhibitory action.

Radix Sophorae Tonkinensis pharmacological action: 1, resisting pathogenic microbes effect: experiment shows that Radix Sophorae Tonkinensis has inhibitory action to staphylococcus aureus, acrothesium floccosum and Candida albicans, has high-efficiency antimicrobial effect to tubercule bacillus.2, the effect to respiratory system: in Radix Sophorae Tonkinensis, contained alkaloid has excited Repiration.Anagyrine, eulexine energy reflex excitation are breathed, and it acts on similar nicotine.

Fructus Arctii pharmacological action: 1, antibiosis and antiviral functions: Fructus Arctii infusion in vitro to cocoon color hair tinea mattress, proper alignment hair tinea mattress, permitted 9 kinds of pathogenic funguses such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand, Pilus Caprae seu Ovis sample microspore tinea mattress, epidermophyton inguinale, epidermophyton rubrum, star-shaped nocardia, rust microspore's tinea bacterium and had bacteriostasis.2, other effects: Arctiin has dilating effect to frog lower limb and rabbit ear blood vessel, and of short duration reduces blood pressure, all have and suppress or paralysis effect isolated rabbit uterus, intestinal tube, nervus motorius and bone network flesh.

Semen Oroxyli pharmacological action: Semen Oroxyli can promote body metabolism, delaying cell aging, improves immunity, clearing away lung-heat throat.Anti-cancer, toxin expelling, quenches one's thirst, and relieves the effect of alcohol.Be the tea a kind of among the people of Minorities in Yunnan, tea shape is beautiful, puts into cup bubble and dances lightly like butterfly, and tea shape is beautiful, and the limpid Folium Camelliae sinensis of millet paste is quiet and beautiful simple and elegant, is again famous and precious middle showy flowers of herbaceous plants energy clearing away lung-heat simply, and acute/chronic bronchitis is had to good curative effect.Seed, peel of stem, containing baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing.

Calyx Seu Fructus Physalis pharmacological action: Calyx Seu Fructus Physalis fruit water extract has antitumaous effect, and the growth of mouse ascites cancer is had to inhibitory action; The fresh juice of its fruit has inhibitory action to staphylococcus aureus, bacillus pyocyaneus etc.; Hepatitis B virus surface antigen is also had to inhibitory action.In addition, water soluble ingredient has the effect of strengthening its contraction to the frog heart, and can cause faint vasoconstriction and hypertension.

Radix Glycyrrhizae pharmacological action: 1, adrenocortical hormone sample effect: Radix Glycyrrhizae extractum, glycyrrhizin and enoxolone have promotion sodium to Healthy People and animal, the effect of water retention; Low dose of glycyrrhizin can make rat chest gland atrophy and adrenal gland's weight increase, and produces the effect of glucocorticoid cortisone sample.When heavy dose of, the effect of glucocorticoid sample is not obvious, only presents the effect of mineralocorticoid sample.3, Detoxication: Radix Glycyrrhizae extractum and glycyrrhizin are poisoning to some drugs, alimentary toxicosis, interior metabolism product are poisoning certain detoxification ability.The active ingredient of Detoxication is glycyrrhizin, detoxification machine is made as glycyrrhizin has adsorption to poisonous substance, glycyrrhizin hydrolyzate glucuronic acid can be combined with poisonous substance, and glycyrrhizin have the effect of adrenocortical hormone sample, the result of the aspect combined factors effects such as detoxification ability of enhancing liver.In addition glycyrrhizin, glycyrrhetate still have anti-inflammatory and antiallergic, anti-liver injury, anti-promoting, antibacterial, anti-AIDS toxic action.

The preparation method of product of the present invention:

1) Fructus Nandinae Domesticae, Lasiosphaera Seu Calvatia, Semen Armeniacae Amarum, Fructus Canarii, the Radix Stemonae, Rhizoma Belamcandae, Radix Sophorae Tonkinensis, Fructus Arctii, Semen Oroxyli, Calyx Seu Fructus Physalis, Radix Glycyrrhizae, through grinding, soaks one hour;

2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;

3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;

5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.

The present invention has the following advantages:

(1) refine pure natural plant Chinese herbal medicine elite composition, nontoxic to human body;

(2) screen the multiple relieving cough and asthma that has, damp eliminating is reduced phlegm, replenishing YIN and removing heat, the natural vegetable Chinese herbal medicine elite of eliminating pathogenic factor for supporting vital QI effect, the symptoms such as pharyngeal sense of discomfort, foreign body sensation, the pharyngeal secretions that can effectively suppress repeatedly to show effect is difficult for bringing up, pharyngeal gargalesthesia, burn feeling, dry sensation;

(3) can improve patients with chronic pharyngitis immunity, health invigorating, improves immunity of organisms and permanent imperial condition of disease power, reduces the attack times of chronic pharyngitis;

(4) can reduce the misery of chronic pharyngitis patients, improve the symptom of patient's upper respiratory tract, improve patients ' life quality.

the specific embodiment:the present invention is described in further detail in conjunction with the embodiments for face:

According to following table institute column data (percentage by weight %) and described step thereof, be configured:

Formula one:

Fructus Nandinae Domesticae 20.0-30.0

Lasiosphaera Seu Calvatia 12.0-20.0

Semen Armeniacae Amarum 9.0-15.0

Fructus Canarii 12.0-20.0

Radix Stemonae 5.0-12.0

Rhizoma Belamcandae 6.0-12.0

Radix Sophorae Tonkinensis 3.0-9.0

Fructus Arctii 15.0-30.0

Semen Oroxyli 4.0-12.0

Calyx Seu Fructus Physalis 6.0-15.0

Radix Glycyrrhizae 2.0-6.0

Water to 100.0

Formula two:

Fructus Nandinae Domesticae 22.0-30.0

Lasiosphaera Seu Calvatia 15.0-20.0

Semen Armeniacae Amarum 11.0-15.0

Fructus Canarii 13.0-20.0

Radix Stemonae 7.0-12.0

Rhizoma Belamcandae 9.0-12.0

Radix Sophorae Tonkinensis 4.0-7.0

Fructus Arctii 18.0-30.0

Semen Oroxyli 6.0-12.0

Calyx Seu Fructus Physalis 9.0-15.0

Radix Glycyrrhizae 3.0-6.0

Water to 100.0

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Formula three:

Fructus Nandinae Domesticae 22.0-38.0

Lasiosphaera Seu Calvatia 15.0-18.0

Semen Armeniacae Amarum 11.0-14.0

Fructus Canarii 13.0-18.0

Radix Stemonae 7.0-11.0

Rhizoma Belamcandae 9.0-10.0

Radix Sophorae Tonkinensis 5.0-6.0

Fructus Arctii 18.0-25.0

Semen Oroxyli 6.0-10.0

Calyx Seu Fructus Physalis 9.0-12.0

Radix Glycyrrhizae 3.0-5.0

Water to 100.0

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Claims (2)

1. the present invention relates to a kind of chronic pharyngitis compound medicines for the treatment of, it is characterized in that thering is following formula (component and percentage by weight % thereof): Fructus Nandinae Domesticae 20.0-30.0, Lasiosphaera Seu Calvatia 12.0-20.0, Semen Armeniacae Amarum 9.0-15.0, Fructus Canarii 12.0-20.0, Radix Stemonae 5.0-12.0, Rhizoma Belamcandae 6.0-12.0, Radix Sophorae Tonkinensis 3.0-9.0, Fructus Arctii 15.0-30.0, Semen Oroxyli 4.0-12.0, Calyx Seu Fructus Physalis 6.0-15.0, Radix Glycyrrhizae 2.0-6.0.

2. described in claim 1, treat a chronic pharyngitis compound medicines, it is characterized in that having following technique:

1) Fructus Nandinae Domesticae, Lasiosphaera Seu Calvatia, Semen Armeniacae Amarum, Fructus Canarii, the Radix Stemonae, Rhizoma Belamcandae, Radix Sophorae Tonkinensis, Fructus Arctii, Semen Oroxyli, Calyx Seu Fructus Physalis, Radix Glycyrrhizae, through grinding, soaks one hour;

2), after big fire is heated to boiling, from boiling 30 minutes, leach the head liquid of boiling medicine;

3) add again clear water, continue slow fire and decoct, repeat 2) step 2 ~ 3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid leaching is mixed, 2000 revs/min are carried out centrifugally, extract the medicinal liquid of supernatant;

5) cooling, take the dish out of the pot, subpackage, high temperature sterilize, the warehouse-in that is up to the standards is standby.