CN107582708A - A kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis and preparation method thereof - Google Patents
A kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis, and its bulk drug includes each composition of following parts by weight：200 250 parts of olive benevolence；150 200 parts of climbing groundsel；350 400 parts of Y biondii(Pamp)D.L.Fu；100 150 parts of cordate houttuynia；200 250 parts of Gardenia；50 100 parts of Chinese prickly ash；100 150 parts of elscholtiza；100 150 parts of balloonflower root；Windproof 100 120 parts；The bulk drug can utilize the edible oil at different temperatures, and drops made from the volatile oil effective ingredient for the treatment of rhinitis is extracted from the bulk drug with the method for " similar to mix ".The Chinese traditional medicine composition preparation of the present invention solves the problems such as inconvenient for use existing for current rhinitis prevention and treatment aspect, preventive effect is poor, and operative treatment is not thorough, and antibiosis extract for treating bacterium produces drug resistance.
Description
Technical field
The present invention relates to a kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis.
Background technology
Nose device, it is the most important respiratory apparatus of human body, by sinotunnel c omplex and nasal sinus body (sinus frontalis, maxillary sinus, sieve sinus, butterfly
Sinus) form, generally nasal sinus body discharges juice by Dou Kou or crack to sinotunnel c omplex, aids in nasal meatus mucociliary
Harmful dust or sex pheromone for being adsorbed in schneiderian membrance etc. is cleared out of the cleaning for maintaining nose device in vitro and health.Positive reason
Under condition, " functions of expelling toxin " of nasal cavity can ensure that adsorbing the harmful dust of nasal cavity or sex pheromone is no more than what human body can be born
Quantity.
Limited by environmental degradation or condition of work, the quantity of the harmful dust or sex pheromone that suck nasal cavity exceedes nose
During the self-cleaning ability of chamber, harmful dust or sex pheromone will meet risk factor such as in nasal cavity abnormal aggregation：By
It is cool, drench with rain, fatigue etc., nasal cavity functions of expelling toxin reduces, and harmful bacteria is able in nasal cavity stop for a long time and amount reproduction,
The acute or chronic inflammation of nasal cavity is caused, triggers various malaise symptoms, such as：Nasal obstruction, rhinorrhea, furious, eye acid is swollen, dizzy, head
Pains etc. can trigger the attached symptoms such as chilly, poor appetite, body many places discomfort simultaneously.
According to domestic and international medical research, substantially clearly：Chronic nasosinusitis (CRS) pathogenic species mainly have Staphylococcus aureus
Bacterium, coagulase-negative staphylococci, streptococcus pneumonia, haemophilus influenzae, catarrh not pull bar bacterium, EHEC, grass green
Streptococcus etc..Virus infection is the primary cause of disease, or the secondary bacterial infection on the basis of virus infects.
Shown according to statistics, in China, the rhinitis incidence of disease is up to 37%, meanwhile, just there is 1-3 people's trouble in every 10 people
There is different degrees of allergic rhinitis.The various malaise symptoms that rhinitis triggers seriously affect the daily life and work of patient,
The body of minor is also produced serious influence with intelligence development simultaneously.
At present, rhinitis mainly solves by preventing and treating two aspects in advance afterwards.
The precautionary measures in advance of rhinitis：
It is main to make daily cleaning to nasal cavity using saline rinsing solutions, harmful dust and sex pheromone are reduced in nasal cavity
Aggregation prevent the generation of rhinitis, there is certain practical value.But nasal cavity is made using saline rinsing solutions daily clear
It is clean to need special implement and use be present with preserving the scarce limits such as inconvenience, water of easily choking, actual effect unobvious.Actual life
In, the people periodically using physiological saline cleaning nose is few.The nasal cavity of physiological saline cleaning simultaneously is only applicable to healthy nasal cavity health care, right
In the nasal cavity of infection inflammation be no substantial effect.
By reasons such as application method, use cost and actual effects, nasal cavity is cleaned using physiological saline to prevent rhinitis
Limit is lacked and there is essence in method.
The treatment afterwards of rhinitis：
Mainly alleviate malaise symptoms, clinical practice operation by clinical application or by surgery excision part nasal cavity tissue
In mainly by cut off nasal polyp and part concha tissue improve nasal obstruction caused by poor aeration symptom, and for sinus frontalis,
The malaise symptoms such as dizzy, headache mainly eliminate discomfort by the treatment of antibiotic caused by the inflammation such as maxillary sinus, sieve sinus, sphenoid sinus
Symptom.Although drug resistance can be produced in human body with the malaise symptoms of respite rhinitis, the use of antibiotic, not only can not
Fundamentally solve the problems, such as rhinitis, can also cause the infringement of deep somatic time, cause that final " no medicine can cure " situation.In nasal cavity
Bacterium in the following manner in vivo produce resistance ability：
1) by producing a variety of inactivators, decomposition is inactivated before antibacterials reach target site, makes antimicrobial
Thing fails or partial failure.
2) by changing affinity of the cell membrane to drug permeability and cell membrane and medicine, to escape controlling for antibiotic
Treat.
" biomembrane " is the important mechanisms that bacterium escapes drug responses, and biomembrane is that bacterial flora is attached to inactive or has work
Property body surface, be embedded in its own caused extracellular matrix formation three-dimensional films sex camplex, then three-dimensional longitudinal direction is raw
It is long, tower structure is ultimately formed, the treatment to the antibacterials of immune response has very high drug resistance.Exempting from for host can be escaped
Epidemic disease acts on, and is difficult to thoroughly remove (referring to the 12nd phase of volume 14 in March, 2010 in infection site《Chinese Tissue Engineering Study is with facing
Bed rehabilitation》The research and progress on bacterial biof iotalm resistance mechanism such as Chen Tiezhu).
Simultaneously because most antibiotics are all to improve illness by way of metabolism enlivens bacterium, and it is in biomembrane
The bacterium at center due to nutriment and oxygen concentration it is relatively low cause activity it is relatively low, the metabolism for escaping antibiotic is protected
Entirely.After bacterial biof iotalm is found from the sinus mucosa of patient first, the research and development of the parties concerned is rapid, and research shows
Biomembrane and CRS have substantial connection, particularly in some recurrences and intractable case, biomembrane be probably CRS inflammation occur and
An important factor for persistently existing (referring to：The 2nd phase of volume 37 in March, 2013《International ENT ＆ HN Surgery Dept. magazine》Liu Dan
The cause and onset of disease mechanism of sword --- chronic rhinosinusitis coexisting).
On December 5th, 2007《JAMA》The current research for delivering doctor of medicine Williamson is shown, is taken
Antibiotic helps adult's sinus infection little.This research from Southampton, Britain university is more than 16 years old thin to 240
Bacterium property sinusitis in patients is observed, 3/4ths patient receive the treatment of antibiotic Amoxicillin (while make with or without
Steroids nasal spray).Other a quarter patient receives the placebo treatment of antibiotic-free, totally 10 days.As a result：(1) two group of trouble
The sinus infection of person alleviates degree difference unobvious；(2) steroids nasal spray has work for the patient of those slight nasal obstruction symptoms
With, and for the patient of those severe nasal blockage symptoms, it is further worsened.
In a word the prevention in advance of nasal cavity problem with afterwards treatment deposit in-convenience in use, preventive effect is poor, and antibiotic excessively makes
The problem of with Induction of bacterial drug resistance.If therefore can solve rhinitis existing above mentioned problem in terms of prevention and treatment, really for
The Gospel of numerous patients with rhinitis.
The content of the invention
The technical problem to be solved in the present invention, it is to provide a kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis and its preparation side
Method, solve in terms of current rhinitis prevention and treatment existing for it is inconvenient for use, preventive effect is poor, and operative treatment is not thorough, antibiotic
Treat the problems such as bacterium produces drug resistance.
What Chinese traditional medicine composition preparation of the present invention was realized in：A kind of Chinese traditional medicine composition preparation for preventing and treating rhinitis, its raw material pack
Include each composition of following parts by weight：
Olive benevolence 200-250 parts；
Climbing groundsel 150-200 parts；
Y biondii(Pamp)D.L.Fu 350-400 parts；
Cordate houttuynia 100-150 parts；
Gardenia 200-250 parts；
Chinese prickly ash 50-100 parts；
Elscholtiza (r ú) 100-150 parts；
Balloonflower root 100-150 parts；
Windproof 100-120 parts.
Wherein, in addition to solvent, the solvent is the edible oil of 11500-13200 parts by weight, it is of the invention it is described can
Edible oil specifically includes：
Camellia oil 2800-3200 parts by weight, and the solvent as climbing groundsel described in the olive Renhe；
Olive oil 5500-6500 parts by weight, and the solvent as the Y biondii(Pamp)D.L.Fu, the cordate houttuynia and Gardenia；
Edible glycerol 3200-3500 parts by weight, and as the Chinese prickly ash, the elscholtiza, the balloonflower root and described windproof
Solvent.
Further, the Chinese traditional medicine composition preparation is to utilize the edible oil at different temperatures, with " similar to mix "
Method extracts drops made from the volatile oil effective ingredient for the treatment of rhinitis from the bulk drug.
What preparation method of the present invention was realized in：A kind of preparation method for the Chinese traditional medicine composition preparation for preventing and treating rhinitis, prepares
Foregoing bulk drug, then carry out following step：
1) dry bulk drug olive Renhe climbing groundsel is taken, olive benevolence 200-250 parts by weight, climbing groundsel 150-200 parts by weight, two
Kind bulk drug mixes after crushing pours into rustless steel container, addition 2800-3200 parts by weight camellia oils, soak at room temperature 24 hours,
Pour into temperature controllable Chinese medicinal steaming boiler, 150 degrees Celsius of 2-2.5 hours of keeping temperature；Then cool down, stand 12 hours, 100 mesh mistakes
Strainer filtering, residue is removed, obtains extract A；
2) dry bulk drug Y biondii(Pamp)D.L.Fu 350-400 parts by weight, cordate houttuynia 100-150 parts by weight, Gardenia 200-250 are taken
Parts by weight, three kinds of bulk drugs mix after crushing pours into rustless steel container, adds 5500-6500 wt parts of olive oil, normal temperature leaching
Bubble 12 hours, pours into temperature controllable Chinese medicinal steaming boiler, 130 degrees Celsius of 1-1.5 hours of keeping temperature；Then cool down, stand 12 small
When, 100 mesh filter screen filtrations, residue is removed, obtains extract B；
3) four kinds of dry surplus stock medicines, including Chinese prickly ash 50-100 parts by weight, elscholtiza (r ú) 100-150 parts, balloonflower root are taken
100-150 parts, windproof 100-120 parts, four kinds of bulk drugs mix after crushing pours into rustless steel container, adds 3200-3500 weights
Part edible glycerol is measured, soak at room temperature 36 hours pours into temperature controllable Chinese medicinal steaming boiler, 110 degrees Celsius of 3-3.5 hours of keeping temperature,
Then cool down, stand 12 hours, 100 mesh filter screen filtrations, remove residue, obtain extract C；
4) extract A, B, C are mixed, pours into temperature controllable Chinese medicinal steaming boiler, 90 degrees Celsius of keeping temperature, continue 15 minutes
, produce Chinese traditional medicine composition preparation of the invention.
Wherein, the broken of the bulk drug of the step 1) is carried out in medicinal herb grinder, crushes time control in 30-40
Second；The broken of the bulk drug of the step 2) is carried out in medicinal herb grinder, crushes time control in the 20-30 seconds；The step
The broken of rapid bulk drug 3) is carried out in medicinal herb grinder, crushes time control in the 40-50 seconds.
The invention has the advantages that：The Chinese traditional medicine composition preparation of the preventing and treating rhinitis of the present invention, there is obvious effect to rhinitis preventing and treating
Fruit, suitable for the prevention and treatment of various people's rhinitis, there is no lasting malaise symptoms in validity period, do not influence work and life
It is living, and be made after drops using simply, conveniently.
Embodiment
The Chinese traditional medicine composition preparation of the preventing and treating rhinitis of the present invention, including bulk drug and solvent.
Wherein, bulk drug includes each composition of following parts by weight：
Olive benevolence 200-250 parts；
Climbing groundsel 150-200 parts；
Y biondii(Pamp)D.L.Fu 350-400 parts；
Cordate houttuynia 100-150 parts；
Gardenia 200-250 parts；
Chinese prickly ash 50-100 parts；
Elscholtiza (r ú) 100-150 parts；
Balloonflower root 100-150 parts；
Windproof 100-120 parts.
Bulk drug main component and effect：
Lan Ren：Lan Ren (Terminalia catappa L.) high megaphanerophyte of combretaceae, seed oil is edible, also hyoscine,
Seed is bitter in taste, puckery, cool in nature, can be clearing heat and detoxicating, there is therapeutic efficiency to abscess of throat, dysentery and pyogenic infections, and oily olive benevolence benevolence contains
Oil mass is up to 44.6%, and oleic acid is up to 27.6%, and linoleic acid is up to 31.8%.By entering to the ethyl acetate extraction part of ethanol extract
Row separation, is identified：11 kinds of compound such as table pinoresinol, sesamin, methysticin wherein gallic acids have anti-inflammatory, resist and dash forward
The multiple biological activities such as change, anti-oxidant, Green Tea Extract, while gallic acid has antitumor, can suppress mastocytoma
Transfer, its bacteriostasis is obvious, has good effect in terms of rhinitis is treated (quoted from tropical and subtropical plant journal in 2014 recklessly
Resolve《The research of oily olive a kind of fruit, such as apple, pear, etc. reality chemical composition》.
Climbing groundsel：Climbing groundsel (Senecio scandens Buch.-Ham.ex D.Don) is catananche, herb
Containing substantial amounts of flavoxanthin, anthocyanidin and a small amount of B- carrotene.With powerful antibacterial and anti-inflammation functions, volatile oil and phenol
Acid compounds are the active ingredient of its antibacterial action.51 kinds of volatility constituents are therefrom identified, according to antiviral study in vitro
Method determines the antiviral activity of climbing groundsel, test result indicates that its volatile oil has different journeys to 16 kinds of viruses listed by experiment
The inhibitory action of degree, fairly obvious to staphylococcus aureus and bacillus subtilis fungistatic effect, research shows to most of
Bacterium has inhibitory action (quoted from the Central South University Wang Meng summers《A thousand li photoactive component ofthe and finger-print research》20140518).
Y biondii(Pamp)D.L.Fu：Magnoliaceae, the bud of Y biondii(Pamp)D.L.Fu (Magnolia biondii), also known as the flower bud of lily magnolia, there is wind dispelling cold dispelling
Logical the effect of stealing reason lung, 15~30% flower bud of lily magnolia decoctions confirm there is drop in terms of having inhibitory action pharmacology to a variety of pathogenic funguses
Pressure, antibacterial, anti-inflammatory, antiallergy etc. act on, and bud contains volatile oil 3.4%, and modern pharmacology research shows that volatile oil composition is
It plays the material base of drug effect, and various extract component have the effects such as different degrees of antibacterial, anti-inflammatory, antiallergic action.Bud
Contained Constituents of The Essential Oil is mainly nopinene, 1, 8-Cineole and camphor, is also contained：Australene, α-and β-phellandrene, sabinene,
α-and γ-terpinene, tert-butyl benzene, aquation sabinene, linalool, α-and β-terpinol, 4- terpinols, beta-elemene are trans
Cloves alkene, β-selinene, torreyol etc..
Antibacterial experiment in vitro shows, to staphylococcus aureus, Diplococcus pneumopniae, Pseudomonas aeruginosa, Shigella flexneri, large intestine
Bacillus has different degrees of inhibitory action, has inhibitory action to Candida albicans and a variety of pathogenic funguses.Experiment shows：It is pungent
It is smooth to have convergence and protective effect to schneiderian membrance, reduce secretion, local Marjoram Extract, circulation improves, and can promote secretion
Absorption and inflammatory resolution.Flower bud of lily magnolia topical application, there are anti-inflammatory and analgesic activity (quoted from Chengdu University of Traditional Chinese Medicine bear day qin《The flower bud of lily magnolia is waved
Hair oil treats the molecular mechanism research of allergic rhinitis》20030510).
Cordate houttuynia：Cordate houttuynia is Saururaceae herbaceos perennial heartleaf houttuynia (Houttuynia cordata Thunb)
Whole herb with root, volatilization oil drop always fresh plant weight 0.018%, including a- firpenes 2, amphene, sabinene, B-pinene, laurene, a- water
Celery alkene, terpinene, to P-cymene, limonene, a-B- ocimenums, terpinolene, perilla oil alkene etc..Antibacterial action：Cordate houttuynia
In decanoyl acetaldehyde be antibacterial active ingredient, to micrococcus catarrhalis, hemolytic streptococcus, Bacillus influenzae, Diplococcus pneumopniae and gold
Staphylococcus aureus have obvious inhibiting effect, also have suppression to make Escherichia coli, shigella dysenteriae, typhoid bacillus and sporothrix
With extracorporeal bacteria inhibitor test also indicates that, its volatile oil has good inhibiting effect to staphylococcus aureus, sarcine, to big
Enterobacteria has inhibitory action.Anti-allergic effects：The obvious antagonism slow reacting substance (SRS-A) of Herba Houttuyniae oil energy, makees to antihistaminicum
With obvious, good anti-allergic effects are presented with (quoted from Chinese medicine company 2008 the 8th phase Hu Ruxiao of volume 17 etc.《The change of cordate houttuynia
Study point and its pharmacological action》.
Cape jasmine：It is the fruit of madder wort cape jasmine, is traditional Chinese medicine, the l batches of medicine-food two-purpose moneys that the category Ministry of Public Health promulgates
Source, there is the effect such as protect liver, cholagogic, decompression, calmness, hemostasis, detumescence.Cape jasmine first recorded in《Sheng Nong's herbal classic》, middle product are classified as, are belonged to
In madder wort cape jasmine Gardeniajas-minoidesEllis fruit, there is purging intense heat relieving restlessness, removing pattogenic heat from the blood and toxic material from the body, heat-clearing profit
The effect of urine, it can be used for treating Vexed, jaundice, blood strangury and dry pain, blood-head go out nosebleed, red eye, swell pain, fiery poison sore wound, outside
Wound strain etc..Gardenoside is mainly contained in cape jasmine.There is reduction, cholagogic, cape jasmine is applied in plurality of Chinese compatibility.Gardenia
Sub- Multiple components have antioxidation, can significantly improve the survival rate of the endothelial cell of damage, have the function that antithrombotic, together
When also there is the effect such as anti-inflammatory, antipathogen (quoted from Volume Four Cui Hong in 2011 etc.《The research that Gardenia chemical compositions and pharmacology are made
Progress》).
Balloonflower root：Balloonflower root is the drying of Campanulaceae balloonflower root (Platycodon grandiflorum (Jacq.) A.DC)
Root, is conventional Chinese medicine, and medicinal balloonflower root is mild-natured, sweet toil, attaches to the lung and stomach meridians, there is the work(such as facilitaing lung, cold dispelling, eliminating the phlegm, relieving sore-throat, apocenosis
Effect, has the effect of notable to respiratory disease.It is main component in balloonflower root pharmacological activity (quoted from 2016 that triterpene soap is sweet
The phase of volume 18 the 1st《Food and medicine》Li Ying etc.《The chemical composition and Advance on Pharmacological Activities of balloonflower root》).
It is windproof：Herbaceos perennial, Gen Kesheng are used.Acrid flavour, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion
The effect of.It is treatment flu, has a headache, the traditional Chinese medicine that rheumatic arthritis is the most frequently used, experiment shows windproof water decoction and volatile oil
Extract can improve the phagocytic activity of mouse macrophage, have and improve immunity of organisms, strengthen the work of specific immune function
With showing powerful antiallergy, antibacterial and antivirus action (quoted from the 2nd phase Dou Hongxia of volume 26 in 2009 etc.《Windproof chemistry
Composition and pharmacology make progress》).
Modern medicine study shows that triggering the bacterium of rhinitis mainly has：Staphylococcus aureus, coagulase-negative grape ball
Bacterium, streptococcus pneumonia, haemophilus influenzae, catarrh not pull bar bacterium, EHEC, Streptococcus viridans etc..Traditional Chinese medicine
Existing thousands of years of history, the inspection of long term medical practice has not only been withstood the effect of many Chinese herbal medicines, and showed
Confirmed for Science Institute.Some medium-height grass the effective elements of the medicines and molecular structure etc. have also been studied clear whole or in part.
Chemical composition is very complicated contained by Chinese herbal medicine, generally there is carbohydrate, amino acid, protein, grease, wax, enzyme, pigment, vitamin, organic
Acid, tannin, inorganic salts, volatile oil, alkaloid, glucoside etc..Each Chinese herbal medicine may all contain Multiple components.
Traditional Chinese medicine therapy absorbs Traditional Chinese medicine water-soluble active ingredient based on oral water decoction, through stomach, passes through rete vasculosum
Active ingredient is transported to lesions position by network.Utilization phase of the Traditional Chinese Medicine based on utilization water soluble ingredient and to traditional medicine volatile oil
To less, utilization of the modern Chinese medicine pharmacy industry to Chinese medicine volatile oil component is mainly system pill or glue earth.Volatile oil is Chinese medicine
The basis of drug effect, there is anti-inflammatory, antiallergy, antimicrobial, anti-mutation and anticancer, anthelmintic action, enzyme inhibition.
Therefore the Chinese traditional medicine composition preparation of the present invention is to utilize solvent at different temperatures, with " similar to mix " (referring to (2016
The 12nd phase of volume 15 December year《Vocational technology》The similar application of the principle in Chemistry for Chinese Traditional Medicine technology that mix such as the old eastern woodss of Liu Liang)；
(the 14th phase of volume 27 in 2016《China Dispensary》The progress of old extra large hawk traditional medicine volatile oil bacteriostatic activity)；(May in 2007
5 phases《Chinese medicine and clinic》The progress of yellow elegant its chemical composition bacteriostasis of phoenix Chinese medical extract)) method from described
Drops made from the volatile oil effective ingredient of bulk drug extraction treatment rhinitis, traditional medicine volatile oil active ingredient can dissolve at high temperature
Into edible oil, i.e., edible oil can displace the volatile oil active ingredient in Chinese medicine at high temperature, be exactly described " phase patibhaga-nimitta
It is molten " principle.Wherein, solvent of the invention is 11500-13200 parts by weight edible oils, specifically be may include：
Camellia oil 2800-3200 parts by weight, and the solvent as climbing groundsel described in the olive Renhe；
Olive oil 5500-6500 parts by weight, and the solvent as the Y biondii(Pamp)D.L.Fu, the cordate houttuynia and Gardenia；
Edible glycerol 3200-3500 parts by weight, and as the Chinese prickly ash, the elscholtiza, the balloonflower root and described windproof
Solvent.
Preparation method is：【Raw material meter takes】→【It is broken】→【Leaching】→【Heating extraction】→【Cooling】→【Filtering】→
【Mixing】→【It is canned】, comprise the following steps that：
1) dry bulk drug olive Renhe climbing groundsel is taken, olive benevolence 200-250 parts by weight, climbing groundsel 150-200 parts by weight, is made
Crushed with medicinal herb grinder, crush time control in the 30-40 seconds.Two kinds of bulk drugs mix pour into rustless steel container after crushing,
2800-3200 parts by weight camellia oils are added, soak at room temperature 24 hours pours into temperature controllable Chinese medicinal steaming boiler, and keeping temperature 150 is Celsius
Degree, continue 2-2.5 hours, under high temperature, the volatile oil component of bulk drug can be dissolved in camellia oil；Then cool down, stand 12
Hour, 100 mesh filter screen filtrations, obtain extract A.
2) dry bulk drug Y biondii(Pamp)D.L.Fu 350-400 parts by weight, cordate houttuynia 100-150 parts by weight, Gardenia 200-250 are taken
Parts by weight, crushed using medicinal herb grinder, crush time control in the 20-30 seconds.Three kinds of bulk drugs mix pour into not after crushing
Become rusty steel container, adds 5500-6500 wt parts of olive oil, soak at room temperature 12 hours, pours into temperature controllable Chinese medicinal steaming boiler, keeps temperature
130 degrees Celsius of degree, continue 1-1.5 hours, the volatile oil component of bulk drug is fully dissolved in olive oil；Then cool down, it is quiet
Put 12 hours, 100 mesh filter screen filtrations, obtain extract B.
3) four kinds of dry surplus stock medicines, including Chinese prickly ash 50-100 parts by weight, elscholtiza (r ú) 100-150 parts, balloonflower root are taken
100-150 parts, windproof 100-120 parts, are crushed using medicinal herb grinder, crush time control in the 40-50 seconds.Four kinds of bulk drug warps
Rustless steel container is poured into mixing after broken, adds 3200-3500 parts by weight edible glycerols, soak at room temperature 36 hours, pours into adjustable
Middle benefit gas medicine boiling vessel, 110 degrees Celsius of keeping temperature, continue 3-3.5 hours, the volatile oil component of bulk drug is fully dissolved to food
With in glycerine, then cool down, stand 12 hours, 100 mesh filter screen filtrations, obtain extract C.
4) extract A, B, C are mixed, pours into temperature controllable Chinese medicinal steaming boiler, 90 degrees Celsius of keeping temperature, continue 15 minutes
, produce Chinese traditional medicine composition preparation of the invention.
The Chinese traditional medicine composition preparation application method of the present invention：The drop of this product 3 to 4 instills nasal cavity, each 1 time sooner or later, continues 15 days left sides
The right side, in the environment of nasal cavity structure bacteria growing inhibiting, suppress the growth and development of bacterium (referring to (phase May the 5th in 2007《China
Medicine and clinic》The progress of yellow elegant its chemical composition bacteriostasis of phoenix Chinese medical extract), by the growth cycle of bacterium,
The bacterium slowly natural death allowed in nasal cavity, recover to normal flora quantity, auxiliary nasal sinus function voluntarily to recover, eliminate rhinitis not
Suitable symptom, the problem of realizing the permanent treatment of rhinitis, while avoid bacterium from producing resistance ability.
Embodiment 1：
The bulk drug of the present embodiment is：Take 20 grams of olive benevolence, 15 grams of climbing groundsel, 35 grams of Y biondii(Pamp)D.L.Fu, 10 grams of cordate houttuynia, Gardenia
20 grams, 5 grams of Chinese prickly ash, 10 grams of elscholtiza (r ú), 10 grams of balloonflower root, windproof 10 grams, 280 grams of camellia oil, 550 grams of olive oil, edible glycerol
320 grams.
By Lan Ren, climbing groundsel, crushed using medicinal herb grinder, crush time control at 30 seconds.Two kinds it is broken after raw material
Rustless steel container is poured into after mixing, camellia oil is added, soak at room temperature 24 hours, pours into temperature controllable Chinese medicinal steaming boiler, keeping temperature
150 degrees Celsius, continue 2 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, remove residue, obtain extract A.
Y biondii(Pamp)D.L.Fu, cordate houttuynia, Gardenia are crushed using medicinal herb grinder, crush time control at 20 seconds.Three kinds broken
Rustless steel container is poured into after raw material mixing afterwards, 550 grams of olive oil is added, soak at room temperature 12 hours, pours into temperature controllable Chinese medicinal steaming
Boiler, 130 degrees Celsius of keeping temperature, continue 1 hour.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, remove residue,
Obtain extract B.
Chinese prickly ash, elscholtiza (r ú), balloonflower root, windproof use medicinal herb grinder are crushed, crush time control at 40 seconds.Four kinds broken
Rustless steel container is poured into after raw material mixing after broken, 320 grams of edible glycerols is added, soak at room temperature 36 hours, pours into temperature controllable
Medicine boiling vessel, 110 degrees Celsius of keeping temperature, continue 3 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, removed residual
Slag, obtain extract C.
Extract A, B, C are mixed, temperature controllable Chinese medicinal steaming boiler is poured into, 90 degrees Celsius of keeping temperature, continues 15 minutes i.e.
Can, Chinese traditional medicine composition preparation is produced, is designated as P1.
Embodiment 2：
The bulk drug of the present embodiment is：Take 22 grams of olive benevolence, 18 grams of climbing groundsel, 38 grams of Y biondii(Pamp)D.L.Fu, 13 grams of cordate houttuynia, Gardenia
22 grams, 8 grams of Chinese prickly ash, 13 grams of elscholtiza (r ú), 13 grams of balloonflower root, windproof 12 grams, 300 grams of camellia oil, 600 grams of olive oil, edible glycerol
330 grams.
By Lan Ren, climbing groundsel, crushed using medicinal herb grinder, crush time control at 35 seconds.Two kinds it is broken after raw material
Rustless steel container is poured into after mixing, camellia oil is added, soak at room temperature 24 hours, pours into temperature controllable Chinese medicinal steaming boiler, keeping temperature
150 degrees Celsius, continue 2.2 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, remove residue, obtain extract A.
Y biondii(Pamp)D.L.Fu, cordate houttuynia, Gardenia are crushed using medicinal herb grinder, crush time control at 25 seconds.Three kinds broken
Rustless steel container is poured into after raw material mixing afterwards, 550 grams of olive oil is added, soak at room temperature 12 hours, pours into temperature controllable Chinese medicinal steaming
Boiler, 130 degrees Celsius of keeping temperature, continue 1.2 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, removed residual
Slag, obtain extract B.
Chinese prickly ash, elscholtiza (r ú), balloonflower root, windproof use medicinal herb grinder are crushed, crush time control at 45 seconds.Four kinds broken
Rustless steel container is poured into after raw material mixing after broken, 320 grams of edible glycerols is added, soak at room temperature 36 hours, pours into temperature controllable
Medicine boiling vessel, 110 degrees Celsius of keeping temperature, continue 3.2 hours, cool down, stand 12 hours, 100 mesh filter screen filtrations, remove
Residue, obtain extract C
Extract A, B, C are mixed, temperature controllable Chinese medicinal steaming boiler is poured into, 90 degrees Celsius of keeping temperature, continues 15 minutes i.e.
Can, Chinese traditional medicine composition preparation is produced, is designated as P2.
Embodiment 3：
The bulk drug of the present embodiment is：Take 25 grams of olive benevolence, 20 grams of climbing groundsel, 40 grams of Y biondii(Pamp)D.L.Fu, 15 grams of cordate houttuynia, Gardenia
25 grams, 10 grams of Chinese prickly ash, 15 grams of elscholtiza (r ú), 15 grams of balloonflower root, windproof 12 grams, 320 grams of camellia oil, 650 grams of olive oil, edible glycerol
350 grams.
By Lan Ren, climbing groundsel, crushed using medicinal herb grinder, crush time control at 40 seconds.Two kinds it is broken after raw material
Rustless steel container is poured into after mixing, camellia oil is added, soak at room temperature 24 hours, pours into temperature controllable Chinese medicinal steaming boiler, keeping temperature
150 degrees Celsius, continue 2.5 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, remove residue, obtain extract A.
Y biondii(Pamp)D.L.Fu, cordate houttuynia, Gardenia are crushed using medicinal herb grinder, crush time control at 30 seconds.Three kinds broken
Rustless steel container is poured into after raw material mixing afterwards, 550 grams of olive oil is added, soak at room temperature 12 hours, pours into temperature controllable Chinese medicinal steaming
Boiler, 130 degrees Celsius of keeping temperature, continue 1.5 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, removed residual
Slag, obtain extract B.
Chinese prickly ash, elscholtiza (r ú), balloonflower root, windproof use medicinal herb grinder are crushed, crush time control at 50 seconds.Four kinds broken
Rustless steel container is poured into after raw material mixing after broken, 320 grams of edible glycerols is added, soak at room temperature 36 hours, pours into temperature controllable
Medicine boiling vessel, 110 degrees Celsius of keeping temperature, continue 3.5 hours.Cooling, 12 hours are stood, 100 mesh filter screen filtrations, removed
Residue, obtain extract C.
Extract A, B, C are mixed, temperature controllable Chinese medicinal steaming boiler is poured into, 90 degrees Celsius of keeping temperature, continues 15 minutes i.e.
Can, Chinese traditional medicine composition preparation is produced, is designated as P3.
The compliance test result of above-described embodiment：
1.1 norm controlling：This product carries out monitoring to physical and chemical index and microbiological indicator, using third party's sampling Detection mode
Sample is detected, it is as a result as follows：
1.2 therapeutic evaluation
Selection is paid a return visit 7 different cities users, and 15 people are paid a return visit in random sampling, to symptom, service condition, treatment
Situation etc. carries out statistical analysis, as a result as follows：
Evaluation criterion：
Cure：After medication 7 days, the symptom such as runny nose, nasal obstruction, dizziness, headache all disappears；
Take a turn for the better：After medication 14 days, the symptom such as runny nose, nasal obstruction, dizziness, headache is aobvious to be improved；
It is invalid：After medication 14 days, clinical symptoms get nowhere without improvement.
Conclusion：15 people are counted, cure 8 people, take a turn for the better 6 people, invalid 1 people, total effective rate 93.3%.Not fed back during treatment has
Adverse reaction.It can be seen that the present invention is easy to use, no sense of discomfort, treatment cycle is short, and therapeutic effect is good and has no side effect；Overcome mesh
The preceding a variety of scarce limits for the treatment of of rhinitis, it is that rhinitis prevents and treats relatively good selection, and bulk drug collection is convenient, cost is low, raw
Production. art is simple, and process equipment is few.
Although the foregoing describing the embodiment of the present invention, those familiar with the art should manage
Solution, the specific embodiment described by us are merely exemplary, rather than for the restriction to the scope of the present invention, are familiar with this
The equivalent modification and change that the technical staff in field is made in the spirit according to the present invention, should all cover the present invention's
In scope of the claimed protection.
Claims (6)
- A kind of 1. Chinese traditional medicine composition preparation for preventing and treating rhinitis, it is characterised in that：Its bulk drug includes each composition of following parts by weight：Olive benevolence 200-250 parts；Climbing groundsel 150-200 parts；Y biondii(Pamp)D.L.Fu 350-400 parts；Cordate houttuynia 100-150 parts；Gardenia 200-250 parts；Chinese prickly ash 50-100 parts；Elscholtiza 100-150 parts；Balloonflower root 100-150 parts；Windproof 100-120 parts.
- A kind of 2. Chinese traditional medicine composition preparation for preventing and treating rhinitis according to claim 1, it is characterised in that：Also include solvent, institute State the edible oil that solvent is 11500-13200 parts by weight.
- A kind of 3. Chinese traditional medicine composition preparation for preventing and treating rhinitis according to claim 2, it is characterised in that：The edible oil tool Body includes：Camellia oil 2800-3200 parts by weight, and the solvent as climbing groundsel described in the olive Renhe；Olive oil 5500-6500 parts by weight, and the solvent as the Y biondii(Pamp)D.L.Fu, the cordate houttuynia and Gardenia；Edible glycerol 3200-3500 parts by weight, and it is used as the Chinese prickly ash, the elscholtiza, the balloonflower root and the windproof solvent.
- A kind of 4. Chinese traditional medicine composition preparation of preventing and treating rhinitis according to Claims 2 or 3, it is characterised in that：The Chinese traditional medicine composition Preparation is to utilize the edible oil at different temperatures, and treatment rhinitis is extracted from the bulk drug with the method for " similar to mix " Volatile oil effective ingredient made from drops.
- A kind of 5. preparation method for the Chinese traditional medicine composition preparation for preventing and treating rhinitis, it is characterised in that：Prepare as claimed in claim 1 former Expect medicine, then carry out following step：1) dry bulk drug olive Renhe climbing groundsel, olive benevolence 200-250 parts by weight, climbing groundsel 150-200 parts by weight, two kinds of originals are taken Material medicine mixes after crushing pours into rustless steel container, adds 2800-3200 parts by weight camellia oils, soak at room temperature 24 hours, pours into Temperature controllable Chinese medicinal steaming boiler, 150 degrees Celsius of 2-2.5 hours of keeping temperature；Then cool down, stand 12 hours, 100 mesh screen packs Filtering, residue is removed, obtains extract A；2) dry bulk drug Y biondii(Pamp)D.L.Fu 350-400 parts by weight, cordate houttuynia 100-150 parts by weight, Gardenia 200-250 weight are taken Part, three kinds of bulk drugs mix after crushing pours into rustless steel container, adds 5500-6500 wt parts of olive oil, soak at room temperature 12 Hour, pour into temperature controllable Chinese medicinal steaming boiler, 130 degrees Celsius of 1-1.5 hours of keeping temperature；Then cool down, stand 12 hours, 100 mesh filter screen filtrations, residue is removed, obtains extract B；3) four kinds of dry surplus stock medicines, including Chinese prickly ash 50-100 parts by weight, elscholtiza (r ú) 100-150 parts, balloonflower root 100- are taken 150 parts, windproof 100-120 parts, four kinds of bulk drugs mix after crushing pours into rustless steel container, adds 3200-3500 parts by weight Edible glycerol, soak at room temperature 36 hours pour into temperature controllable Chinese medicinal steaming boiler, 110 degrees Celsius of 3-3.5 hours of keeping temperature, then Cooling, 12 hours are stood, 100 mesh filter screen filtrations, remove residue, obtain extract C；4) extract A, B, C are mixed, pours into temperature controllable Chinese medicinal steaming boiler, 90 degrees Celsius of keeping temperature continues to produce for 15 minutes The Chinese traditional medicine composition preparation.
- A kind of 6. preparation method of Chinese traditional medicine composition preparation for preventing and treating rhinitis according to claim 5, it is characterised in that：The broken of the bulk drug of the step 1) is carried out in medicinal herb grinder, crushes time control in the 30-40 seconds；The broken of the bulk drug of the step 2) is carried out in medicinal herb grinder, crushes time control in the 20-30 seconds；The broken of the bulk drug of the step 3) is carried out in medicinal herb grinder, crushes time control in the 40-50 seconds.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464469A (en) * | 2018-10-19 | 2019-03-15 | 江苏浦金药业有限公司 | A kind of extracting method of the dried venom of toads |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850190A (en) * | 2006-02-24 | 2006-10-25 | 徐利洪 | Rhinitis ointment and preparation method thereof |
| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
| CN106880722A (en) * | 2015-12-15 | 2017-06-23 | 张维庆 | It is a kind of to treat compound traditional Chinese medicine composite of rhinitis and preparation method thereof |
-
2017
- 2017-09-22 CN CN201710864292.7A patent/CN107582708A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850190A (en) * | 2006-02-24 | 2006-10-25 | 徐利洪 | Rhinitis ointment and preparation method thereof |
| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
| CN106880722A (en) * | 2015-12-15 | 2017-06-23 | 张维庆 | It is a kind of to treat compound traditional Chinese medicine composite of rhinitis and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464469A (en) * | 2018-10-19 | 2019-03-15 | 江苏浦金药业有限公司 | A kind of extracting method of the dried venom of toads |
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