CN102512344A - Blumea balsamifera extract, preparation method and application thereof in oral care and clean product - Google Patents
Blumea balsamifera extract, preparation method and application thereof in oral care and clean product Download PDFInfo
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Abstract
The invention relates to a preparation method of blumea balsamifera extract, which comprises the steps of: a) carrying out a water vapor distillation method on blumea balsamifera and respectively obtaining volatile oil, filtrate and dreg of decoction; b) drying the filtrate and obtaining water extract; c) extracting the dreg of decoction by ethanol, filtering the extracted liquid, concentrating the filtrate into thick paste with the density of 1.05 at the temperature of 60 DEG C, using ethyl acetate with the weight equal to that of the thick paste for extracting, recovering and drying the ethyl acetate, and obtaining ethyl acetate extract; and d) mixing the volatile oil, the water extract and the ethyl acetate extract, and obtaining the blumea balsamifera extract. The invention also relates to the blumea balsamifera extract prepared by the method. The invention further relates to the application of the blumea balsamifera extract in an oral care and clean product. When being added into the oral care and clean product, the blumea balsamifera extract has the functions of treating inflammation, sterilizing and clearing the throat when being used for cleaning the oral cavity in the daily life, and is especially suitable for the occasion that teeth can not be brushed or are inconvenient to brush.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to Herba Blumeae Balsamiferae extract and preparation method thereof and the application in the MC cleaning product.
Background technology
Along with the raising day by day of living standard, people also improve the health care consciousness of self gradually, and oral cavity health is one of them, and oral cavity health had both comprised the prior MC that is meant of daily oral cavity cleaning, to reach the purpose that keeps oral health.MC cleaning series products in the market comprises oral nursing liquid, collutory, mouthspray, toothpaste, chewing gum etc.
Traditional oral cavity cleaning hygienic article, its basic function is cleaning teeth, fresh breath reaches the purpose that keeps oral cavity cleaning.In recent years,, oral-cavity cleaning products has been proposed more requirement, also increased some auxiliary prevention oral diseases except cleaning the teeth, the oral cavity has been had the function of nursing health effect because the consumer healthcare realizes continuous enhancing.Again because the Chinese medicinal plant active component has the incomparable advantages of Western medicine such as natural, safe, so become the emphasis of current development on the market with the functional type oral-cavity cleaning products of active ingredient of Chinese herbs.Along with the development of modernization of Chinese medicine technology, the method for active ingredient of Chinese herbs research and utilization has also been obtained good development, this prevents oral disease that good technical support is provided for oral-cavity cleaning products utilizes active ingredient of Chinese herbs assist.
Oral inflammation, oral ulcer, aphtha be a kind of be the oral mucosa limitation ulcer infringement of characteristics with outbreak periodically repeatedly, can spontaneous recovery, can betide any position of oral mucosa, see that with lip, cheek, tongue severe patient can involve pharyngeal mucosa more.Much patients are along with the prolongation of the course of disease, and the ulcer area increases, and number increases, and pain increases the weight of, and healing stage prolongs, and shorten interval etc., and influence is eaten and spoken.Though the Therapeutic Method to stomatitis, oral ulcer, pharyngitis, laryngitis, aphtha, halitosis, periodontitis, gingivitis is a lot; But basically all be symptomatic treatment; Purpose mainly is to ease the pain or reduce recurrent number, but can not control recurrence fully, so the prevention primary disease is particularly important.
For specific crowd or specific occasion; Do not have conditioned disjunction not brush teeth for various reasons with toothpaste, as: with after the meal, see the client before, before and after the tooth treatment, or the old people of loss of tooth, the child that can not brush teeth etc.; In this case, select oral nursing liquid or collutory more suitable.
Herba Blumeae Balsamiferae is the fresh or dry aerial parts of feverfew Herba Blumeae Balsamiferae Blumea balsamifera (L.) DC.; Being commonly called as " Na Long " (multitude's medicine name), " Balsamiferou Blumea Herb ", is one of China Li nationality, Miao ethnic group's folk medicine, acrid in the mouth, hardship; Warm in nature; Go into liver, kidney, urinary bladder channel, have that warming middle-JIAO is invigorated blood circulation, a function of regulating menstruation, wind-damp dispelling, be used to treat diseases such as affection of exogenous wind-cold dysentery, stomachache, borborygmus, swelling, menoxenia, bones and muscles pain.Herba Blumeae Balsamiferae is mainly as the raw material that extracts Chinese mugwort powder, Blumeae preparatum Tabellae and Oleum Blumeae Balsamiferae; It is historical to have long use; The Ming Dynasty as far back as China, the geographic doctor among the people of Nationality in Hainan Province apply ointment or plaster with regard to useful its blade bake and treat the experience of skin burn, weapons wound, obtain water decoctions with other medical materials of the composite minority of its blade; Washout treatment women expelling wind and removing dampness in puerperal, most women of the Li nationality all know this function.
Modern study shows; Mainly contain volatile ingredient and flavones ingredient in the Herba Blumeae Balsamiferae; Mainly contain L-Borneolum Syntheticum, β-caryophyllene, Camphora, australene, nopinene, Fructus Citri Limoniae alcohol, linalool, borneol acetate isoreactivity composition in the Herba Blumeae Balsamiferae volatile oil, have diaphoresis, relieving convulsion, anthelmintic respectively, relieving asthma, heart tonifying, antitussive, eliminate the phlegm, effect such as antibiotic, antiviral.Flavones ingredient, especially flavanone have very strong antioxidation.Department of chemistry of Zhongshan University separates from Herba Blumeae Balsamiferae and obtains blumeatin, and finds that this chemical compound has certain cardiac vascular activity and antioxidation, anti-experimental character hepatic injury effect.Through Herba Blumeae Balsamiferae extract blumeatin and chemical improvement thing thereof are carried out the research of pharmacologically active, find that this compounds has liver protective effect preferably and stronger inhibition lipid peroxidation.Flavanone in the Herba Blumeae Balsamiferae has protective effect to the rat experiment liver damage, has anti-CCl
4, AAP and TAA the acute liver damage effect.Hepatocyte is cultivated by the lipid peroxidation injury rat Yuan Dynasty protective effect is arranged.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of Herba Blumeae Balsamiferae extract.
The present invention also aims to provide Herba Blumeae Balsamiferae extract by this method preparation.
The present invention also aims to provide the application of this Herba Blumeae Balsamiferae extract in the MC cleaning product.
In order to realize the object of the invention, the present invention provides a kind of method for preparing of Herba Blumeae Balsamiferae extract, and this method comprises the following steps:
A) make Herba Blumeae Balsamiferae carry out steam distillation to obtain volatile oil, filtrating and medicinal residues respectively;
B) make the said filtrating in the step a) dry to obtain water extract;
C) make the said medicinal residues in the step a) use ethanol extraction; With extracting liquid filtering and filtrating is concentrated into 60 ℃ of lower densities is 1.05 thick paste; The ethyl acetate of weight such as usefulness and said thick paste extracts, and reclaims ethyl acetate and dry to obtain ethyl acetate extract; And
D) mix said volatile oil, said water extract and said ethyl acetate extract, thereby obtain said Herba Blumeae Balsamiferae extract.
Herba Blumeae Balsamiferae (Blumea balsamifera (L) DC) belongs to the dry herb of Herba Blumeae Balsamiferae for the Compositae Herba Blumeae Balsamiferae.Being the commonly used medicinal of nationalitys such as the Li nationality, Miao ethnic group and Zhuang, also is the plant origin of producing Blumeae preparatum Tabellae simultaneously.Main product in Guizhou, province such as Guangxi, Yunnan and Taiwan.According to putting down in writing in " Chinese medicine voluminous dictionary ": Herba Blumeae Balsamiferae is warm in nature, and acrid in the mouth has warming middle-JIAO and invigorates blood circulation, the effect of expelling wind and removing dampness, anti-inflammatory analgesic.Cold-damp be can treat and cold-damp dysentery, diseases such as stomachache borborygmus, traumatic injury knife injury and hypertension can be used for treating; And for diseases such as advanced menstruation, massive postpartum vaginal bleeding, puerperal edema, infertility, the erosion of vulva curative effect is preferably arranged also, also can be used for burn, scald and skin injury and mosquito bite etc. in addition.Be raw material with the Herba Blumeae Balsamiferae, the Chinese mugwort oil that is produced in the process of refining Blumeae preparatum Tabellae has blood vessel dilating, brings high blood pressure down and suppresses orthosympathetic effect.
Preferably, in said step a), operating weight is that the water logging bubble Herba Blumeae Balsamiferae of 8 times of Herba Blumeae Balsamiferae weight spends the night, and places the volatile oil extractor reflux, extract, then together.
Wherein, steam distillation is a method well-known to those skilled in the art, means medical material that contains volatile ingredient and water condistillation, and volatile ingredient is distillated with steam in the lump, obtains the leach extraction method of volatile ingredient through condensation.This method be applicable to have volatility, can not be destroyed with vapor distillation, the lixiviate of stable and indissoluble or water-fast medicinal ingredient in water.Common equipment is multipotency extraction pot, volatile oil extraction pot, and it is widely used in activity in production.In the present invention,, no volatile oil stops to extract operation when flowing out.
Like what use among this paper, dehydrated alcohol and ethanol water contained in term " ethanol ".Preferably, in said step c), said ethanol is the ethanol water of 60-95 volume %.
More preferably, in said step c), said extraction comprises that cold-maceration extracts, circumfluence method is extracted and percolation extracts.
Preferably, when extracting through circumfluence method, extraction time is generally 2-4 time, and extracting solvent is the ethanol water of 60 volume %, the ethanol water of 80 volume % or the ethanol water of 95 volume %, and the extraction weight of solvent is 2-4 a times of medicinal residues weight.
In the method for the invention, the inventor finds amazedly, most preferably; In said step c); Make the said medicinal residues in the step a) carry out circumfluence method extraction 3 times, each all operating weights are the ethanol water of 95 volume % of 3 times of medicinal residues weight, and extraction time is respectively 2h, 1.5h and 1h.At the fungistatic effect under this condition significantly greater than the Herba Blumeae Balsamiferae extract that under other conditions, prepares.
Preferably, in said step c), the ethyl acetate of weight such as usefulness and said thick paste extracts 3 times.
The present invention also provides the Herba Blumeae Balsamiferae extract through above-mentioned preparation.
The present invention also provides the application of said Herba Blumeae Balsamiferae extract in the MC cleaning product.Preferably, said MC cleaning product is oral nursing liquid, collutory, mouthspray, toothpaste or chewing gum.
The application of said Herba Blumeae Balsamiferae extract in oral nursing liquid is with extracting with said method in the substrate that the Herba Blumeae Balsamiferae extract that obtains adds the MC cleaning product to, being prepared into the MC cleaning product.Add MC cleaning series products substrate to and comprise any antiseptic or antibacterial, acid adjustment or accent alkali liquor, aromatic, excipient, dispersion diluent, toner, stabilizing agent, thickening agent, surfactant and other known conventional adjuvant that allows to be added in this series products.
The present invention has following advantage and beneficial effect with respect to prior art:
(1) Herba Blumeae Balsamiferae extract adds in oral nursing liquid and the mouthspray as additive, can be in the daily cleaning oral cavity anti-inflammation and sterilization, the effect of pharynx-clearing throat-benefiting, especially to can not or the inconvenience crowd and the occasion of brushing teeth with toothbrush.
(2) Herba Blumeae Balsamiferae extract is as playing the effect that slows down oral inflammation, oral cavity gingival hemorrhage symptom preferably in additive adding toothpaste and the collutory.Join the chewing gum of processing in the prescription of chewing gum and after chew in the oral cavity, can fully discharge, and get into digestive tract, bring into play its protective effect oral cavity, digestive tract and respiratory tract with saliva.
(3) Herba Blumeae Balsamiferae extract is applied in the MC cleaning product, and is easy to use, and treatment oral disease effect is remarkable, has no side effect, and is easy to accepted by people.
(4) the Herba Blumeae Balsamiferae extract method for preparing is simple, and production cost is little, adds in the MC cleaning product, and is little to MC cleaning product cost impact, still, greatly improves the use value of MC cleaning product aspect the MC cleaning.
The specific embodiment
Below description through the specific embodiment the present invention is described further; But this is not to be limitation of the present invention; Those skilled in the art are according to basic thought of the present invention; Can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within scope of the present invention.
In method as herein described, except as otherwise noted, otherwise said operation is all depressed at 1 standard atmosphere and is carried out.
The preparation of embodiment 1 Herba Blumeae Balsamiferae extract
Get Herba Blumeae Balsamiferae 100 gram, pulverized 40 mesh sieves after the oven dry, uses weight to spend the night, place volatile oil extractor to extract then, till no longer including the volatile oil outflow, thereby obtain volatile oil, filtrating and medicinal residues respectively as the distilled water immersion of 8 times of Herba Blumeae Balsamiferae weight.Make said filtrate decompression drying to obtain the water extract of Herba Blumeae Balsamiferae.Make said medicinal residues carry out circumfluence method and extract 3 times, each all operating weights are the ethanol water of 95 volume % of 3 times of medicinal residues weight, and extraction time is respectively 2h, 1.5h and 1h.Merge extractive liquid, filters, and it is 1.05 thick paste that filtrating is concentrated into 60 ℃ of lower densities; And extract 3 times with ethyl acetate, each weight all with weight such as said thick paste, combining extraction liquid; And the reclaim under reduced pressure ethyl acetate, drying and crushing obtains the ethyl acetate extract of Herba Blumeae Balsamiferae.Merge the water extract of Herba Blumeae Balsamiferae, the ethyl acetate extract and the volatile oil of Herba Blumeae Balsamiferae, obtain Herba Blumeae Balsamiferae extract 18 grams.
The preparation of embodiment 2 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, difference is to make medicinal residues to carry out reflux, extract, 2 times, and each all operating weights are the ethanol water of 60 volume % of 4 times of medicinal residues weight, and extraction time is respectively 2h and 1.5h.
The preparation of embodiment 3 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, difference is to make medicinal residues to carry out reflux, extract, 4 times, and each all operating weights are the ethanol water of 80 volume % of 2 times of medicinal residues weight, and extraction time is respectively 2h, 1.5h, 1h and 0.5h.
The preparation of embodiment 4 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, difference is to make medicinal residues to carry out reflux, extract, 2 times, and each all operating weights are the ethanol water of 80 volume % of 2 times of medicinal residues weight, and extraction time is respectively 2h and 1.5h.
The preparation of embodiment 5 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, difference is to make medicinal residues to carry out reflux, extract, 4 times, and each all operating weights are the ethanol water of 60 volume % of 4 times of medicinal residues weight, and extraction time is respectively 2h, 1.5h, 1h and 0.5h.
Test Example 1
Because main antibacterial is staphylococcus aureus and Candida albicans in the oral cavity, therefore investigate its application in the MC cleaning product through the bacteriostatic test of Herba Blumeae Balsamiferae extract of the present invention.
Bacteriostatic test
Adopt filter paper method classical in this area to carry out bacteriostatic test, wherein:
1. material
1.1 supply the examination strain
Staphylococcus aureus (Staphylococcus aureus) ATCC 25923, Candida albicans (Candida albicans) ACTT 12228 is all available from Chinese biological goods calibrating institute.
1.2 culture fluid
Nutrient agar and nutrient broth are all available from BeiJing ZhongKe's space in morning experimental facilities company limited.
1.3 test method
Take by weighing Herba Blumeae Balsamiferae extract 1 gram among the embodiment 1 to 5 respectively; After the water dissolution filtration with 8 grams; Deionized water dilution with 15 grams; Add the sodium chloride of 1.5 grams, the dehydrated alcohol of 1.5 grams, the glycerol of 3 grams, the polysorbas20 of 0.3 gram, the aspartame of 0.05 gram, the sodium carboxymethyl cellulose mixing and stirring of 0.3 gram successively, add the deionized water of 80 grams at last again, thereby process collutory 1 to 5.
Staphylococcus aureus and Candida albicans are inoculated on the agar plate nutritional solution plane, evenly gather during inoculation.The aseptic circular filter paper sheet of tweezer uses collutory 1 to 5 respectively.Filter paper is moistening, make filter paper drop on it when vertically leaving standstill just begin to drip.Filter paper is attached on the culture fluid of inoculated bacteria.Agar plate placed in 37 ℃ the incubator incubation 24 hours.Measure the diameter of antibacterial ring.Measuring 3 times averages.
1.4 the result sees the following form
The diameter of antibacterial ring is big more, shows that bacteriostasis is strong more.Visible from last table, the effect of the collutory 1 of the Herba Blumeae Balsamiferae extract of embodiment 1 is significantly higher than the effect of collutory of the Herba Blumeae Balsamiferae extract of other embodiment unexpectedly.
The preparation of embodiment 6 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, it is 1.10 thick paste that difference is filtrating is concentrated into 60 ℃ of lower densities, thereby obtains Herba Blumeae Balsamiferae extract 12 grams.
The preparation of embodiment 7 Herba Blumeae Balsamiferae extracts
According to preparing Herba Blumeae Balsamiferae extract with embodiment 1 identical mode, it is 1.20 thick paste that difference is filtrating is concentrated into 60 ℃ of lower densities, thereby obtains Herba Blumeae Balsamiferae extract 10 grams.
Embodiment 8 Herba Blumeae Balsamiferae extracts add in the oral nursing liquid substrate
Take by weighing Herba Blumeae Balsamiferae extract 1 gram among the embodiment 1; With the water dissolution of 8 grams,, add the vitamin C of 0.1 gram, the hibitane of 0.01 gram, the PEG400 of 1 gram, the Aspartame of 0.02 gram, the glycerol of 1.5 grams, the Mentholum of 0.01 gram, the dehydrated alcohol of 0.1 gram with the deionized water dilution of 15 grams; Mixing and stirring; The water that adds 75 grams again, the sodium dihydrogen phosphate adjusting pH value that adds 0.002 gram at last is 8, sterilization filling.
Embodiment 9 Herba Blumeae Balsamiferae extracts add in the oral spray substrate
Take by weighing the xylitol that Herba Blumeae Balsamiferae extract 2 grams, 0.1 gram water solublity Herba Menthae brain, 0.1 gram Aspartame, 0.2 gram dehydrated alcohol, 2 among the embodiment 1 restrain, be dissolved in the deionized water of 100 grams, in sterile filling and the sprayer bottle.
Embodiment 10 Herba Blumeae Balsamiferae extracts add in the toothpaste matrix
Take by weighing Herba Blumeae Balsamiferae extract 3 grams among the embodiment 1,, filter with the deionized water dissolving of 15 grams.The deionized water dilution filtrating of reuse 8 grams; Add the insoluble Polymeric sodium metaphosphate. of 40 grams, the dicalcium phosphate dihydrate of 5 grams, the aluminium hydroxide of 3 grams, the glycerol of 20 grams, the titanium dioxide of 1 gram, the sodium benzoate of 0.6 gram, the N-sodium lauroyl sarcosine of 3 grams, the aspartame of 005 gram, the Oleum menthae of 0.05 gram successively, add 1.3 gram deionized water and stirring mixings at last again and get final product.
Embodiment 11 Herba Blumeae Balsamiferae extracts add in the chewing gum substrate
Take by weighing Herba Blumeae Balsamiferae extract 3 grams among the embodiment 1, the hydroxypropyl amylcose acetate of 20 grams, the corn syrup (430 Baume degrees) of 75 grams, the water of 1.6 grams and the glycerol of 0.2 gram and in stainless-steel pan, be heated to 80 ℃; Mix homogeneously; Cool to the Herba Menthae Rotundifoliae mixing that adds 0.2 gram after 60 ℃; And be divided into the spherolite of 2.5 grammes per square metres while hot, sprinkle xylosic alcohol powder for each beadlet; In the relative humidity held of room temperature and 45% after 3 hours, packing.
Claims (9)
1. the method for preparing of a Herba Blumeae Balsamiferae extract, this method comprises the following steps:
A) make Herba Blumeae Balsamiferae carry out steam distillation to obtain volatile oil, filtrating and medicinal residues respectively;
B) make the said filtrating in the step a) dry to obtain water extract;
C) make the said medicinal residues in the step a) use ethanol extraction; With extracting liquid filtering and filtrating is concentrated into 60 ℃ of lower densities is 1.05 thick paste; The ethyl acetate of weight such as usefulness and said thick paste extracts, and reclaims ethyl acetate and dry to obtain ethyl acetate extract; And
D) mix said volatile oil, said water extract and said ethyl acetate extract, thereby obtain said Herba Blumeae Balsamiferae extract.
2. method according to claim 1 is characterized in that, in said step a), operating weight is that the water logging bubble Herba Blumeae Balsamiferae of 8 times of Herba Blumeae Balsamiferae weight spends the night, and places the volatile oil extractor reflux, extract, then together.
3. method according to claim 1 is characterized in that, in said step c), said ethanol is the ethanol water of 60-95 volume %.
4. method according to claim 3 is characterized in that, in said step c), said extraction comprises that cold-maceration extracts, circumfluence method is extracted and percolation extracts.
5. method according to claim 4; It is characterized in that, in said step c), make the said medicinal residues in the step a) carry out circumfluence method extraction 3 times; Each all operating weights are the ethanol water of 95 volume % of 3 times of medicinal residues weight, and extraction time is respectively 2h, 1.5h and 1h.
6. according to each described method in the claim 3 to 5, it is characterized in that in said step c), the ethyl acetate of weight such as usefulness and said thick paste extracts 3 times.
7. one kind is passed through the Herba Blumeae Balsamiferae extract that each described method prepares in the claim 1 to 6.
8. the application of the described Herba Blumeae Balsamiferae extract of claim 7 in the MC cleaning product.
9. application according to claim 8 is characterized in that, said MC cleaning product is oral nursing liquid, collutory, mouthspray, toothpaste or chewing gum.
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| CN103525848A (en) * | 2013-09-30 | 2014-01-22 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera internal root-kaurene synthase gene Bb-KS, encoding protein thereof and gene cloning method |
| CN103525848B (en) * | 2013-09-30 | 2015-08-05 | 中国热带农业科学院热带作物品种资源研究所 | Herba Blumeae Balsamiferae Nei Gen-kaurene synthase gene Bb-KS, its coded protein and gene clone method |
| CN105193665A (en) * | 2015-10-26 | 2015-12-30 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera oral care solution, and preparation method and application thereof |
| CN106074223A (en) * | 2016-07-01 | 2016-11-09 | 贵州艾力康中草药开发有限公司 | A kind of Miao Ethnomedicine Herba Blumeae Balsamiferae toothpaste and preparation method thereof |
| CN106214716A (en) * | 2016-08-31 | 2016-12-14 | 中国热带农业科学院热带作物品种资源研究所 | A kind of buccal containing Herba Blumeae Balsamiferae extract and preparation method thereof |
| CN106913602A (en) * | 2017-01-24 | 2017-07-04 | 中国热带农业科学院热带作物品种资源研究所 | A kind of Blumea balsamifera gynaecologic washing lotion and its preparation method and application |
| CN110623866A (en) * | 2019-10-10 | 2019-12-31 | 贵州宏宇药业有限公司 | Toothpaste for preventing hand-foot-mouth disease and oral herpes of children and preparation method thereof |
| CN111904903A (en) * | 2020-07-13 | 2020-11-10 | 鲁可 | Oral cavity gargle and preparation method thereof |
| CN111904903B (en) * | 2020-07-13 | 2022-09-20 | 鲁可 | Oral cavity gargle and preparation method thereof |
| CN112870115A (en) * | 2021-02-25 | 2021-06-01 | 中国热带农业科学院热带作物品种资源研究所 | Special-effect south medicine compound toothpaste for middle-aged and elderly people and preparation method thereof |
| CN113577120A (en) * | 2021-07-23 | 2021-11-02 | 贵州大学 | Blumea balsamifera extract composition and application thereof in preparation of anti-inflammatory and analgesic drugs |
| CN113425647A (en) * | 2021-08-06 | 2021-09-24 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Preparation method and application of blumea balsamifera dreg total flavone extract |
| CN113750198A (en) * | 2021-10-21 | 2021-12-07 | 中国热带农业科学院热带作物品种资源研究所 | Compound oral care solution and preparation method thereof |
| CN114569519A (en) * | 2022-04-15 | 2022-06-03 | 贵州黄果树立爽药业有限公司 | Alcohol-free mouth wash and preparation method thereof |
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