CN101933977A - Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof - Google Patents
Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof Download PDFInfo
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- CN101933977A CN101933977A CN 201010298277 CN201010298277A CN101933977A CN 101933977 A CN101933977 A CN 101933977A CN 201010298277 CN201010298277 CN 201010298277 CN 201010298277 A CN201010298277 A CN 201010298277A CN 101933977 A CN101933977 A CN 101933977A
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Abstract
The invention relates to a traditional Chinese medicine composition against tooth sensitivity and a preparation method of toothpaste containing the traditional Chinese medicine composition against the tooth sensitivity. Wherein the composition comprises the following traditional Chinese medicine components against the tooth sensitivity by weight percent: 20-70% of long pepper, 20-70% of sanchi, 5-50% of honeysuckle flower extract and 2-20% of calamine. The traditional Chinese medicine components against the tooth sensitivity can play the good anti-tooth sensitivity role and simultaneously have certain effects for tooth bleeding, gingival inflammation, swelling and pain and the like. The traditional Chinese medicine composition can be applied in the toothpaste, mouthwash, dentifrice, tooth gel, chewing gums and other dental supplies.
Description
Technical field
The present invention relates to the Chinese medicine composition of anti-sensitivity of tooth, and a kind of preparation method that contains the Chinese medicine composition toothpaste of anti-sensitivity of tooth.
Background technology
Dental hypersensitiveness is perplexing people's daily life, and severe patient can cause other concurrent diseases such as oral cavity, heart.The phenomenon that tooth is ached can occur when people take food acid, sugar water fruit or hot and cold food, this pain can be very sharp-pointed, unexpected, and gos deep into the teleneuron in the tooth.Dental hypersensitiveness claims the sensitivity dentin again, be that tooth is subjected to environmental stimuli, as caused symptoms of aching such as temperature (hot and cold), chemical substance (acid, sweet) and mechanisms (rub or sting hard thing), its characteristics for outbreak rapidly, pain is sharp-pointed, the time is of short duration.At present, it be unclear that, three kinds of theories are arranged for the pathogenesis of dental hypersensitiveness.Neural theory, dentinal fibers conduction theory and fluid dynamic theory.Wherein the fluid theory it think that acting on Dentinal outside stimulus has caused inside or outside the flowing of dentinal tubule's content, thisly unusual mobilely be passed to dental pulp, thereby cause the excitement of dental pulp nerve fiber, produce the pain sensation.Lower floor of odontoblast, odontoblast's layer and the intratubular nerve fiber of dentin internal layer change all very sensitivity to the mobile or unexpected pressure of liquid, and this also is the reason that dentin hypersensitiveness takes place.And another viewpoint is thought, the pathology essence of dentin hypersensitiveness can be counted as " odontoblastic process's inflammation ".The natural pathological change process of dentin hypersensitiveness was divided into for three phases: ooze out the phase, the degeneration necrosis phase, the phase is repaired in calcification.Which kind of pathology theory no matter, dentin hypersensitiveness take place all be that open dentinal tubule causes and flows and the excitation and the inflammation-related of dental pulp or canaliculi dentales nerve or endochylema.Thereby anti-sensitivity of tooth medicine generally is divided into Theory of Convergence Classes from pharmacological angle classification, filling class, calcification reparation class.Theory of Convergence Classes promptly plays dehydration, solidifies dentin cell prominent or the elimination dental pulp neurocyte inflammation and the excitation of exposure.The filling class forms gelatinous precipitate often in dentinal tubule, combine but do not produce true property with tissue of tooth, and these precipitate may be washed away by saliva, so formulation rate is big, uses but action effect generally is used for clinical speciality dentistry rapidly more.Class is repaired in calcification can make the hard tooth tissue remineralization, and the remineralization material is deposition and the open little tube passage of reparation slowly.Remineralization needs the time longer relatively.In sum, three class medicines are owing to mechanism of action difference, and action effect has his own strong points respectively shortage, because the cause of disease, the process of sensitivity of tooth are very complicated, therefore any medicine all can not be in full force and effect.Simultaneously, said medicine adopt more medicine type by oral, smear or dentist's specialty operation is implemented, the mode that can be used for daily oral care product implements to reach medicable successful example seldom.Trace it to its cause, may be because enforcement time of oral care product short, unstable active components, or other compositions cause drug effect interference etc.
Chinese medicine is the rarity of Chinese medicine culture.Motherland's medical science is thought, the generation of any disease, evolution all are that paathogenic factor acts on human body, and body yin or yang excessly declines partially, the result of internal organs meridian function imbalance and cause.Bias of medicine mainly contains four gas, the five tastes, lifting, reinforcing and reducing, return through, poisonous aspect such as nontoxic.If the state of an illness is heavier, or state of an illness more complicated, single is used and is difficult to avoid untoward reaction, therefore often needs to use simultaneously two or more medicines.Medicine is used, can take place between medicine and the medicine some interact if any can strengthen or reduce original drug effect, what have can suppress or eliminate toxic and side effects, what have then can produce or strengthen toxicity.
Summary of the invention
The purpose of this invention is to provide particularly toothpaste and preparation method thereof of a kind of Chinese medicine composition of anti-sensitivity of tooth and oral care product.
The Chinese medicinal components of anti-sensitivity of tooth of the present invention said composition by weight percentage is composed of the following components:
Fructus Piperis Longi 20～70%, Radix Notoginseng 20～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Fructus Piperis Longi is the main component that is used for the treatment of dentine hypersensitivity, and it can play the effect of paralysis dental nerve; Radix Notoginseng and Flos Lonicerae have the good curing effect for gingival hemorrhage and damage; Calamina then is the effect that the skin that festers is had the convergence granulation promoting.Above ratio is determined by a large amount of tests, has considered therapeutic effect and the factor of making toothpaste stability simultaneously.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Fructus Piperis Longi can be the Fructus Piperis Longi powder, other form of Fructus Piperis Longi oil and Fructus Piperis Longi, and preferred Fructus Piperis Longi powder, preferred weight percent is 45-60%; If select the Fructus Piperis Longi powder for use, fineness is more than 200 orders, if adopt Fructus Piperis Longi oil, then content of piperine should be 50～65%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Radix Notoginseng can be a Radix Notoginseng powder, other form of arasaponin and Radix Notoginseng, and preferred arasaponin, preferred weight percent is 45-60%; If select Radix Notoginseng powder for use, fineness is more than 200 orders, if adopt the Radix Notoginseng extracting solution, then arasaponin content should be more than 50%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Flos Lonicerae extract can be a Flos Lonicerae extractive solution, other form of Flos Lonicerae extractum and Flos Lonicerae, and preferred Flos Lonicerae extractive solution, preferred weight percent is 7-30%; If select Flos Lonicerae extractive solution for use, chlorogenic acid content wherein should be 30～50%, if adopt Flos Lonicerae extractum, then chlorogenic acid content should be more than 30%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Calamina can be that preferred weight percent is 5-15% through forging or not forged, preferably not forged; No matter forged still not forged the Calamina that is adopted is, and fineness all should be more than 200 orders.
The Chinese medicine composition of above-mentioned anti-sensitivity of tooth of the present invention screens plurality of Chinese according to Chinese medicine performances such as " four gas, the five tastes; seven emotions ", the property of medicine according to screening of medicaments is carried out compatibility and experiment by the principle of " mutual reinforcement between, the mutual-assistance, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition ", and the mutual compatibility principle of complementarity of plant source medicinal and mineral sources medicine has been researched and developed can have the Chinese medicine composition of curative effect of medication in oral care product.This Chinese medicine composition can just can play anti-preferably sensitivity of tooth effect by simple daily use, and dental haemorrhage, various focusing depths represented are swollen and ache etc. has certain effect simultaneously.
The Fructus Piperis Longi that the present invention adopts is climbed up by holding on to the shape liana for the Piperaceae Piper, and its main component is piperine, Palmic acid, tetrahydropiperic acid, piperidines, volatile oil, N-isobutyl group decadinene, amide etc.The Fructus Piperis Longi warming spleen and stomach for dispelling cold, the medicine commonly used of treatment interior cold disease.Fructus Piperis Longi is the immaturity fruit ear of Piperaceae plant Fructus Piperis Longi, and a kind of special fragrance is arranged, and acrid in the mouth is peppery.Fructus Piperis Longi is in the news to have at analgesia, calmness, antiinflammatory, convulsion etc. has better action to be widely used.Radix Notoginseng contains Saponin, is mainly ginsenoside Rb1, Rg1, Rg2 and a small amount of ginsenoside Ra, Rb2, Rb and Re.In addition, still contain flavonoid glycoside, starch, protein, oils and fats etc.Nature and flavor: warm in nature, sweet in the mouth, little hardship.Compendium of Material Medica cloud: " Radix Notoginseng hemostasis, the blood that looses, analgesic therapy." Radix Notoginseng eats something rare, eliminating blood stasis to promote regeneration of blood, subduing swelling and relieving pain, and have hemostasis not stay blood stasis, stronger analgesia, anti-inflammatory effect are arranged.Flos Lonicerae has another name called Radix Ophiopogonis, is the perennial half evergreen winding bejuco of Caprifoliaceae.The sweet cold fragrance of its property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison.Calamina is a carbonate mineral calcite family smithsonite, and the master contains zinc carbonate, and property is sweet, warm, nontoxic.Be widely used in department of dermatologry, as anticorrosion, convergence, protective agent treatment scytitis or the surface injury of moderate, external can suppress local aureus growth.
Above-mentioned anti-sensitivity of tooth Chinese medicinal components can apply on the toothpaste, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water in the toothpaste component, it is characterized in that: the drug composition in the anti-sensitivity of tooth in toothpaste with the mastic ratio is by weight percentage:
Mastic 90～99.9%, anti-sensitivity of tooth Chinese medicine composition 0.1～10%.
The optimal percentage by weight of anti-sensitivity of tooth Chinese medicine composition is 0.5～5%;
The lotion of toothpaste manufacture method of above-mentioned prescription is: add wetting agent, add again binding agent stir fast homogenizing, successively add sweeting agent, etc. additive, add the anti-sensitivity of tooth Chinese medicinal components that configures again, foaming agent and antiseptic, and evenly stir; Evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stirs homogenizing, and the degassing, Paste Preparation are finished.
Toothpaste is considered the most suitable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, is suitable for too at other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum.
The specific embodiment
Technique effect of the present invention can further specify by embodiment.
Embodiment 1 contains the preparation and the control experiment of anti-sensitivity of tooth Chinese medicinal components toothpaste
Table 1 Example formulations table
Wherein, the optimization proportioning of the Chinese medicinal components of III group is as follows:
Fructus Piperis Longi 20-40%,
Radix Notoginseng 20-40%
Calamina 10-20%
Flos Lonicerae extract 5-20%
The manufacture method of the toothpaste of above-mentioned prescription is: glycerol, sorbitol, water are mixed, add saccharin sodium, sodium benzoate, carboxymethyl cellulose, sodium lauryl sulphate, thickening type silicon dioxide more successively, stir homogenizing fast, add the anti-sensitivity of tooth Chinese medicinal components that configures again, add friction-type silicon dioxide and stir homogenizing, evacuation adds essence at last, stir homogenizing, the degassing, Paste Preparation are finished.Toothpaste is considered the most suitable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, and other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum are suitable for too.
Four groups of toothpaste shown in the his-and-hers watches 1 carry out antiallergic sense clinical trial, take the double-blind trial method, and 90 patients that suffer from sensitivity of tooth of picked at random are divided into equal three groups.The toothpaste that they (brush teeth twice) on the basis of daily habits and organize with I, II, III respectively every day continues to use three months.Result of the test sees Table 2.
Table 2 result of the test
Result of the test shows that the result of test group II and blank assay group I does not have significant difference, and the test group III and the preceding two groups of results that have added anti-sensitivity of tooth Chinese medicine composition have significant difference, and antiallergic sense effect is obvious.From interpretation of result, though Fructus Piperis Longi all has the effect of relieving the pain to toothache in various reading up the literature, test discovery through us, this effect is at this of short duration administering mode, as brushes teeth, effect and not obvious in the process of gargling.Take a turn for the better and find simultaneously at the experimentation of test group III that the personnel oral cavity state that takes one's test has more significantly, when alleviating sensitivity of tooth the curative effect gingival hemorrhage is also arranged preferably, phenomenon such as root of the tooth redness has tangible minimizing.We think it may is owing to the mutual reinforcement between between the component, the performance of auxilliary effect raising curative effect of medication mutually.
Embodiment 2 contains the preparation of the dentifrice of anti-sensitivity of tooth Chinese medicinal components:
Various raw material constituent ratios are as follows:
Calcium carbonate 60-75%
Sodium bicarbonate 5-10%,
Sodium lauryl sulphate 8-10%
Saccharin sodium 0.2-1%
Natural menthol 1-1.5%
The smart 0.5-1% of Herba Menthae powder
The Chinese medicine composition 5-10% of anti-sensitivity of tooth
The proportioning of the Chinese medicine composition of anti-sensitivity of tooth is as follows:
Fructus Piperis Longi 40-50%,
Radix Notoginseng 20-50%
Calamina 5-10%
Flos Lonicerae extract 5-20%
Compound method is as follows: at first, calcium carbonate, sodium bicarbonate, saccharin sodium, Herba Menthae powder essence, Natural menthol are ground to form fine powder cross 250 mesh sieves, after again Fructus Piperis Longi, Radix Notoginseng, Calamina, Flos Lonicerae extract being made powder and crossing 300 mesh sieves, with aforementioned mixture and sodium lauryl sulphate mix homogeneously, at last, every part of 10g-50g of packing.
Claims (9)
1. the Chinese medicine composition of an anti-sensitivity of tooth, composed of the following components by weight percentage:
Fructus Piperis Longi 20～70%, Radix Notoginseng 20～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%.
2. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Fructus Piperis Longi is Fructus Piperis Longi powder or Fructus Piperis Longi oil, wherein, when selecting the Fructus Piperis Longi powder for use, the fineness of Fructus Piperis Longi powder is more than 200 orders, and the percentage by weight of Fructus Piperis Longi powder in Chinese medicine composition is 45%-60%; When selecting Fructus Piperis Longi oil for use, then the content of piperine in the Fructus Piperis Longi oil is 50～65%.
3. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Radix Notoginseng is selected from Radix Notoginseng powder, arasaponin or Radix Notoginseng extract, when selecting arasaponin for use, the percentage by weight of arasaponin in Chinese medicine composition is 45-60%; When selecting Radix Notoginseng powder for use, the Radix Notoginseng powder fineness is more than 200 orders; When selecting Radix Notoginseng extract for use, the arasaponin content in the extract should be more than 50%.
4. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Flos Lonicerae extract is selected from Flos Lonicerae extractive solution or Flos Lonicerae extractum, when selecting Flos Lonicerae extractive solution for use, percentage by weight in Chinese medicine composition is 7-30%, and the chlorogenic acid content in the Flos Lonicerae extractive solution should be 30～50%; When selecting Flos Lonicerae extractum for use, the chlorogenic acid content in the extractum should be more than 30%.
5. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Calamina is that no matter forged still not forged the Calamina that is adopted is through forging or not forged, and fineness all should be more than 200 orders.
6. Chinese medicine composition toothpaste that contains anti-sensitivity of tooth, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water in the lotion of toothpaste component, it is characterized in that also comprising in the toothpaste Chinese medicine composition of anti-sensitivity of tooth, by weight percentage:
The Chinese medicine composition 0.1～10% of mastic 90～99.9%, anti-sensitivity of tooth;
Wherein, in the Chinese medicine composition of described anti-sensitivity of tooth by weight percentage: Fructus Piperis Longi 20～70%, Radix Notoginseng 20～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Fructus Piperis Longi is Fructus Piperis Longi powder or Fructus Piperis Longi oil, and wherein, when selecting the Fructus Piperis Longi powder for use, the fineness of Fructus Piperis Longi powder is more than 200 orders, and the percentage by weight of Fructus Piperis Longi powder in Chinese medicine composition is 45%-60%; When selecting Fructus Piperis Longi oil for use, then the content of piperine in the Fructus Piperis Longi oil is 50～65%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Radix Notoginseng is selected from Radix Notoginseng powder, arasaponin or Radix Notoginseng extract, and when selecting arasaponin for use, the percentage by weight of arasaponin in Chinese medicine composition is 45-60%; When selecting Radix Notoginseng powder for use, the Radix Notoginseng powder fineness is more than 200 orders; When selecting Radix Notoginseng extract for use, the arasaponin content in the extract is greater than 50%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Flos Lonicerae extract is selected from Flos Lonicerae extractive solution or Flos Lonicerae extractum, when selecting Flos Lonicerae extractive solution for use, the percentage by weight in Chinese medicine composition is 7-30%, and the chlorogenic acid content in the Flos Lonicerae extractive solution should be 30～50%; When selecting Flos Lonicerae extractum for use, the chlorogenic acid content in the extractum should be greater than 30%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Calamina is that no matter forged still not forged the Calamina that is adopted is through forging or not forged, and fineness all should be more than 200 orders.
7. a kind of Chinese medicine composition toothpaste that contains anti-sensitivity of tooth according to claim 6, it is characterized in that: the percentage by weight of the Chinese medicine composition of anti-sensitivity of tooth in toothpaste counts 0.5～5%.
8. a method for preparing as toothpaste as described in the claim 6 is: add wetting agent, add again binding agent stir homogenizing after, add sweeting agent and additive successively, add the anti-sensitivity of tooth Chinese medicine composition that configures again, foaming agent and antiseptic, and evenly stir; Evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stirs homogenizing, and the degassing, Paste Preparation are finished.
9. the application of the Chinese medicine composition of the described anti-sensitivity of tooth of claim 1 in the preparation oral care product, described oral care product comprises collutory, dentifrice, tooth gel and chewing gum.
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| CN102784209A (en) * | 2012-08-10 | 2012-11-21 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN104207973A (en) * | 2014-07-26 | 2014-12-17 | 安顺学院 | Method for preparing toothpaste from extract of leaves of sweet potato |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN104522279A (en) * | 2015-01-30 | 2015-04-22 | 云南省药物研究所 | Chewing gum containing total saponin of panax notoginseng and preparation method thereof |
| CN104644502A (en) * | 2015-02-09 | 2015-05-27 | 福建美力生生物科技股份有限公司 | Camellia oil toothpaste formula and application of camellia oil in preparing toothpastes |
| CN107213073A (en) * | 2017-07-06 | 2017-09-29 | 李明劲 | A kind of toothpaste containing notoginseng glycol saponin and preparation method thereof |
| CN107714569A (en) * | 2017-12-07 | 2018-02-23 | 威海职业学院 | A kind of preparation method of fragrant plant mouthwash |
| CN108324611A (en) * | 2018-03-26 | 2018-07-27 | 天马（安徽）国药科技股份有限公司 | A kind of herbal medicine Radix Notoginseng whitening toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102784209A (en) * | 2012-08-10 | 2012-11-21 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN102784209B (en) * | 2012-08-10 | 2014-12-17 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN104207973A (en) * | 2014-07-26 | 2014-12-17 | 安顺学院 | Method for preparing toothpaste from extract of leaves of sweet potato |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN104522279A (en) * | 2015-01-30 | 2015-04-22 | 云南省药物研究所 | Chewing gum containing total saponin of panax notoginseng and preparation method thereof |
| CN104644502A (en) * | 2015-02-09 | 2015-05-27 | 福建美力生生物科技股份有限公司 | Camellia oil toothpaste formula and application of camellia oil in preparing toothpastes |
| CN107213073A (en) * | 2017-07-06 | 2017-09-29 | 李明劲 | A kind of toothpaste containing notoginseng glycol saponin and preparation method thereof |
| CN107714569A (en) * | 2017-12-07 | 2018-02-23 | 威海职业学院 | A kind of preparation method of fragrant plant mouthwash |
| CN108324611A (en) * | 2018-03-26 | 2018-07-27 | 天马（安徽）国药科技股份有限公司 | A kind of herbal medicine Radix Notoginseng whitening toothpaste |
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