CN104983752B - A kind of Chinese medicine composition that treating mouth disease, oral-cavity article and preparation method - Google Patents
A kind of Chinese medicine composition that treating mouth disease, oral-cavity article and preparation method Download PDFInfo
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Abstract
This patent application discloses a kind of Chinese medicine compositions for treating mouth disease, including following components in percentage by weight to be uniformly mixed: Poria cocos 5%~25%；Gypsum 40%~80%；Keel 10%~35%.The present invention also provides a kind of oral-cavity articles containing the Chinese medicine composition, further include matrix by mass percentage, and the matrix includes moisturizer, rubbing agent, thickener, surfactant, sweetener, preservative and fragrance regulator, and surplus is water.The present invention also provides a kind of preparation methods of toothpaste containing Chinese medicine composition, include the following steps: that moisturizer is added, it adds thickener after mixing evenly, sweetener, preservative, surfactant is added, adds the Chinese medicine composition prepared, it is sufficiently stirred, rubbing agent and water are added, fragrance regulator is stirring evenly and then adding into, is sufficiently stirred, vacuum outgas, cream processed are completed.The oral-cavity article treatment canker sore and gingivitis effect prepared using the Chinese medicine composition of present patent application is good.
Description
Technical field
The present invention relates to a kind of medical, dental or the preparation of dressing, and in particular to a kind of mouth disease for the treatment of
Chinese medicine composition, oral-cavity article and preparation method.
Background technique
Swelling and aching of gum, canker sore and the tip of the tongue erosion and pain are commonly known as oral cavity " excessive internal heat " symptom.Canker sore is one
The mouth disease of recurrent exerbation caused by kind is multifactor, is the highest a kind of disease of disease incidence in oral keritonocytes.Flu, essence
Situations such as refreshing nervous, depressed, can cause the generation of the disease, which has the characteristics that periodical, recurrent and self limiting, generally
It can self-healing at 10 days or so.Since the course of disease is longer and pain, often make troubles to patient and pain.Canker sore be apt to occur in lip,
Cheek, lingual margin etc. can occur at any position of mucous membrane.
Gingivitis is a kind of common oral cavity chronic disease, and main clinical manifestation is bleeding gums, swelling and aching of gum etc.,
Disease incidence is up to 70%~90%.If gingivitis cannot control for a long time, even more serious periodontal disease can be developed into
Disease, eventually leads to the loosening of tooth and falls off, and influences oral health.It is well known that plaque is cause periodontal disease most main
Factor is wanted, therefore, inhibiting the formation of plaque is the key that prevent or mitigate gingivitis.
Currently, canker sore can be used to treat and the Chinese herbal medicine of gingivitis to be more, Chinese Traditional Medicine is raw materials used to be mostly
Plant or mineralogical composition.Wherein, plant is generally the extracts such as its root, stem and leaf, by practice and screening in 1,100, be included in " in
State's pharmacopeia " medicinal herb components with its unique medical value and safety be the rarity of the Chinese nation.With scientific and technological level
Continuous improvement, its clear active constituent of analysis method can be used by having nearly 3800 kinds of raw materials, while carry out qualitative or quantitative inspection
It surveys.The effect of active constituent, is also constantly confirming.
Application of the medicinal herb components in oral-cavity article has long history.Such as dialled for the Bi of dental pain, it is main to use
The abdominal pain caused by stomach cold, acid regurgitation, diarrhea, coronary disease and angina pectoris, nervous headache and toothache etc.；For mitigating gingivitis
Honeysuckle (honeysuckle), be recorded in " Mingyi Bielu " earliest, be classified as top grade, honeysuckle property is sweet cold, and function is clearing heat and detoxicating, anti-inflammatory is moved back
It is swollen, it is all effective to bacillary dysentery and various purulent diseases.The coptis for relieving inflammation or internal heat, records in Compendium of Material Medica: " its root
Like a chain of pearls or a string of beads and color is yellow, therefore named." rhizomes (coptis): it is bitter, it trembles with fear.Heat-clearing and damp-drying drug, purging fire for removing toxin.For reduce swelling hemostasis Radix Notoginseng,
Recorded in Compendium of Material Medica, styptic powder blood analgesic therapy, golden sword arrow wound, fall flutter cane sore, blood goes out more than person, chew rotten painting, or mix it for end,
Its blood is i.e. only.Also main hematemesis and epistaxis, lower blood bloody flux, metrorrhagia incessant menorrhea, postpartum extravesated blood not under, blood transport blood pain, Akamu carbuncle swells, tiger
Sting all diseases of snakebite.Gypsum rubrum for relieving inflammation or internal heat is recorded according to " this is through meeting source ", and " gypsum rubrum controls the medicine-feeding of heart kidney accumulated heat, Shennong's Herbal
It controls in abdomen and gathers, salty energy softening hard masses；As burnt in the hot skin of body, salty energy fall fire."
Existing patent discloses Chinese herbal medicine for treating aphthae, if patent name is treatment aphthae at present
Oral preparation of Chinese traditional medicinal, Authorization Notice No. be CN102370878B patent document in, describe following content: by 24 kinds of medium-height grass
Medicine powder mixed preparing forms, and the Chinese medicine powder includes following compositions: the coptis, radix scutellariae, Cortex Phellodendri, rhizoma anemarrhenae, indigo naturalis, Radix Angelicae Sinensis,
Radix Codonopsis, radix scrophulariae, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, keel, raw cape jasmine, folium isatidis, the root bark of Chinese wolf-berry, gypsum, radix rehmanniae recen, Rehmannia glutinosa, wild jujube
Benevolence, the seed of Oriental arborvitae, the fruit of glossy privet, cortex moutan, cimicifugae foetidae, Radix Isatidis amount to 24 kinds of Chinese herbal medicines and are made by doses crushing mixing；Mainly
By indigo naturalis 6g；Each 15g of the coptis, radix scutellariae, Cortex Phellodendri, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, Poria cocos, folium isatidis, cortex moutan, cimicifugae foetidae, Radix Codonopsis；Rhizoma anemarrhenae, wheat
Winter, raw cape jasmine, the root bark of Chinese wolf-berry, radix rehmanniae recen, each 20g of Rehmannia glutinosa；Radix scrophulariae, fruit of glossy privet 25g；Keel, gypsum, semen ziziphi spinosae, the seed of Oriental arborvitae,
Each 30g of Radix Isatidis.
Wherein, Poria cocos has significant antibacterial, anti-inflammatory, antivirus action.It is discovered by experiment that 100% Poria cocos oozes out
Liquid filter paper has inhibiting effect to staphylococcus aureus, Pseudomonas aeruginosa, bacillus anthracis, Escherichia coli, beta streptococcus；Fu
Subcutaneous rat granuloma caused by Siberian cocklebur extract paraxylene cotton balls is formed with inhibiting effect.Gypsum category minerals as traditional Chinese medicine.Gypsum shape
At there is strong evaporation in the process, gypsum, which has, brings down a fever, pungent taste, cold and cool feature." Bencao Jingshu " is recorded, " pungent energy
Expelling pathogenic factors from muscles and skin, it is sweet can slow heat, Great Cold and and it is pungent sweet, then can be except big heat." keel, it is ancient times mammal like an elephant class, rhinoceros class, three-toed
The fossil of the bone of horse etc..Tranquillizing the mind by relieving convulsion is cured mainly, arrest sweating controlling nocturnal emission with astringent drugs, stop blooding puckery intestines, and myogenic sore, frightened epilepsy is demented, and ulcer is not received long
Mouthful.
But above-mentioned oral preparation of Chinese traditional medicinal there is problems: traditional Chinese medicinal components contained by 1. raw materials are very more, and Chinese medicine group
Dividing has certain side effect to human body, so the more then pharmacological properties of component are difficult to control, and exist between traditional Chinese medicinal components and mutually inhibits
Or the effect promoted, it is easy to influence drug effect, causes therapeutic effect bad；2. above-mentioned preparation is a kind of oral preparation of Chinese traditional medicinal, and mouth
It takes relatively large to the side effect of body；3. above-mentioned preparation is only used for treatment canker sore, because of canker sore, patient generally also can
There is gingivitis, so gingivitis then needs individually to go to a doctor, uses above-mentioned preparation inconvenient.
The oral-cavity articles such as exploitation and development Chinese herbal toothpaste treatment canker sore and gingivitis also become research in recent years
New issue.It is no lack of Chinese herbal toothpaste or other oral-cavity articles, but the effect in terms for the treatment of canker sore, gingivitis in commercial product
It is unsatisfactory.
Summary of the invention
The purpose of the present invention is providing a kind of Chinese medicine for treating canker sore and the good treatment mouth disease of gingivitis effect
Composition, oral-cavity article and preparation method.
In order to achieve the above objectives, technical scheme is as follows:
A kind of Chinese medicine composition for treating mouth disease, including following components in percentage by weight are uniformly mixed: Poria cocos 5%
~25%；Gypsum 40%~80%；Keel 10%~35%.
The present invention also provides a kind of oral-cavity articles containing Chinese medicine composition, further include matrix, the matrix include moisturizer,
Rubbing agent, thickener, surfactant, sweetener, preservative and fragrance regulator, surplus are water.
The present invention also provides a kind of preparation methods of toothpaste, include the following steps:
(1) moisturizer is added, adds thickener and stirs evenly；
(2) sweetener, preservative, surfactant is added and stirs evenly；
(3) Chinese medicine composition is added, is sufficiently stirred；
(4) rubbing agent and water are added, fragrance regulator is stirring evenly and then adding into, is sufficiently stirred；
(5) vacuum outgas, cream processed are completed.
Beneficial effects of the present invention:
1. in above-mentioned Chinese medicine composition, gypsum plays the role of heat-clearing；Poria cocos, keel play antibacterial anti-inflammatory, alleviate
The effect of ulcer.The present invention only uses gypsum, Poria cocos and keel, it is clear that and used component is few, so pharmacological property is easy to control, three
Compatible use can mutually inhibit toxicity and the side effect to human body, while can improve heat-clearing, antibacterial anti-inflammatory, the work for alleviating ulcer
With the oral-cavity article containing above-mentioned Chinese medicine composition, is particularly suitable for treatment canker sore and gingivitis, therapeutic effect are good.
2. component contained by the toothpaste of the traditional chinese medicine composition of the invention is less, and toothpaste is not oral medicine, by using toothpaste
It is very small to the side effect of body to treat canker sore and gingivitis, and canker sore and tooth can be treated while brushing teeth
Oulitis, it is very easy to use.
Further, including following components in percentage by weight is uniformly mixed: Poria cocos 15%；Gypsum 60%；Keel 25%.
It is found through overtesting, the effect of the important composition of said ratio is very good.
It further, further include gypsum rubrum 0.1%~5% in component.Gypsum rubrum is cold in nature often with gypsum compatibility, has clear
The effect of hot purging intense heat, relieving restlessness are quenched the thirst, sweating expelling pathogenic factors from muscles and skin it can treat the diseases such as hyperpyrexia polydipsia, hot eyes dentalgia.
Further, the gypsum rubrum is 3%.It is found through overtesting, the effect of the important composition of said ratio is very
It is good.
It further, further include stone swallow 0.1%~10% in component.Stone swallow is loaded in Tang Materia Medica earliest, " likeness in form blood clam and
It is small, heavily fortified point weight such as stone." stone swallow is lightly seasoned, cool in nature；Nontoxic, stone swallow has with Poria cocos, gypsum, keel compatibility removes damp and hot, diuresis,
The effect of moving back mesh screen.
Further, the stone swallow is 6%.It is found through overtesting, the effect of the important composition of said ratio is very good.
Further, the Poria cocos is Poria cocos powder or tuckahoe extracts, selects the granularity of Poria cocos powder more than 180 mesh.
Further, the oral-cavity article is in toothpaste, tooth powder, mouthwash, tooth gel, tooth paste or ointment preparation
One kind.A variety of oral-cavity articles contain Chinese medicine composition, to guarantee that selectable product category is more.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail:
Embodiment 1-10, comparative example 1-7 are that Chinese medicine composition is added in toothpaste, and the Poria cocos in above-described embodiment uses Fu
Siberian cocklebur powder, tuckahoe extracts are identical as the using effect of Poria cocos powder.It prepares after Chinese medicine composition mainly crushes each raw material and mixes
Uniformly, the granularity of smashed each raw material is greater than 180 mesh, the Chinese traditional medicine composition in 1-10 of the embodiment of the present invention, comparative example 1-7
The granularity of each ingredient of object is 200 mesh or so.
Moisturizer of the invention, can in polyethylene glycol, glycerol, sorbierite, propylene glycol one or more at
Point combination, in 1-10 of the embodiment of the present invention, comparative example 1-7, moisturizer selects glycerol, sorbierite, other combinations and glycerol, mountain
Pears alcohol effect is identical.
Rubbing agent, can in calcium carbonate, silica, calcium monohydrogen phosphate, calcium glycerophosphate one or more at
The combination divided.In 1-10 of the embodiment of the present invention, comparative example 1-7, moisturizer selects silica.Other combinations and silica phase
Together.
Thickener can be selected from sodium carboxymethylcellulose, hydroxyethyl cellulose, xanthan gum, carrageenan, guar gum, card wave
The combination of one or more kinds of ingredients in nurse.In 1-10 of the embodiment of the present invention, comparative example 1-7, thickener selects carboxymethyl fine
Dimension element.Other combinations are identical as carboxymethyl cellulose.
Surfactant, can be one or more kinds of in amino acid surfactant, lauryl sodium sulfate
The combination of ingredient.In 1-10 of the embodiment of the present invention, comparative example 1-7, surfactant selects lauryl sodium sulfate.Other combinations
It is identical as lauryl sodium sulfate.
Sweetener is selected from saccharin, saccharin sodium, Aspartame, neotame, sodium cyclohexylsulfamate, aspartoyl phenylpropyl alcohol ammonia
The combination of one or more kinds of ingredients in sour methyl esters alitame, Sucralose.In 1-10 of the embodiment of the present invention, comparative example 1-7,
Sweetener selects saccharin sodium.Other combinations are identical as saccharin sodium.
Preservative, one or more kinds of ingredients in sodium benzoate, parabens and its sodium salt, potassium sorbate
Combination.In 1-10 of the embodiment of the present invention, comparative example 1-7, preservative selects sodium benzoate.Other combinations are identical as sodium benzoate.
The preparation method of the toothpaste containing Chinese medicine composition of 1-10 of the embodiment of the present invention, comparative example 1-6, including walk as follows
It is rapid: (1) that glycerol and sorbierite is added, is uniformly mixed；(2) sodium carboxymethylcellulose is added to stir evenly；(3) be added saccharin sodium,
Sodium benzoate, lauryl sodium sulfate are simultaneously uniformly mixed；(4) Chinese medicine composition is added, is sufficiently stirred；(5) silica is added
And water, it stirs evenly；(6) essence is added, is sufficiently stirred；(7) vacuum outgas, cream processed are completed.
Experiment 1
A kind of Clinical efficacy of the following toothpaste containing Chinese medicine composition in terms for the treatment of canker sore
One, experimental method
1. using embodiment 1-9, the toothpaste (totally 16 groups) of comparative example 1-7 is tested, and every group is selected 20 people to test.Year
Age was differed from 11 years old to 72 years old, and male to female ratio is close to 1:1；
2. being used by physician guidance patient without the toothpaste in the toothpaste of Chinese medicine composition, embodiment, application method is complete
Unanimously, it is desirable that patient is brushed teeth 2 times using toothpaste daily, and 3 minutes or more every time, and cooperate in canker sore partial smearing toothpaste 2
It is secondary, during using toothpaste, other unmated any whole bodies and local application；
3. patient is respectively using after without the toothpaste in the toothpaste of Chinese medicine composition, embodiment, and the 3-5 days, 1-2 weeks and 2-
Further consultation inspection in 3 weeks simultaneously records.The medical for the first time and subsequent record content of check each time includes canker sore number, size, pain
Pain degree and the course of disease etc. of each canker sore breaking-out.
Through trimestral clinical observation, the results are shown in Table 1:
Table 1
| Toothpaste | Efficiently individual quantity | Invalid number | Total number | Effective percentage/% |
| Embodiment 1 | 15 | 5 | 20 | 75 |
| Embodiment 2 | 17 | 3 | 20 | 85 |
| Embodiment 3 | 15 | 5 | 20 | 75 |
| Embodiment 4 | 16 | 4 | 20 | 80 |
| Embodiment 5 | 16 | 4 | 20 | 80 |
| Embodiment 6 | 16 | 4 | 20 | 80 |
| Embodiment 7 | 17 | 3 | 20 | 85 |
| Embodiment 8 | 12 | 8 | 20 | 60 |
| Embodiment 9 | 17 | 3 | 20 | 85 |
| Embodiment 10 | 17 | 3 | 20 | 85 |
| Comparative example 1 | 13 | 7 | 20 | 65 |
| Comparative example 2 | 16 | 4 | 20 | 80 |
| Comparative example 3 | 14 | 6 | 20 | 70 |
| Comparative example 4 | 15 | 5 | 20 | 75 |
| Comparative example 5 | 14 | 6 | 20 | 70 |
| Comparative example 6 | 15 | 5 | 20 | 75 |
| Comparative example 7 | 6 | 14 | 20 | 30 |
Compare conclusion:
1. embodiment 1 is significantly more than having for comparative example 1 compared with comparative example 1, using the efficiently individual quantity of the toothpaste of embodiment 1
Effect number, therapeutic effect are obvious.In embodiment 1, Poria cocos accounting in Chinese medicine composition is 5%.So as to obtain, Chinese medicine group
It closes in object, by mass percentage, Poria cocos is lower than 5%, and therapeutic effect is decreased obviously.
2. embodiment 2 is significantly more than having for comparative example 2 compared with comparative example 2, using the efficiently individual quantity of the toothpaste of embodiment 2
Effect number, therapeutic effect is obvious, and in embodiment 2, Poria cocos accounting in Chinese medicine composition is 25%.So as to obtain, Chinese medicine
In composition, by mass percentage, Poria cocos is more than 25%, and therapeutic effect is decreased obviously.
3. embodiment 3 is significantly more than having for comparative example 3 compared with comparative example 3, using the efficiently individual quantity of the toothpaste of embodiment 3
Effect number, therapeutic effect are obvious.In embodiment 3, gypsum accounting in Chinese medicine composition is 80%.So as to obtain, Chinese medicine
In composition, by mass percentage, gypsum is higher than 80%, and therapeutic effect is decreased obviously.
4. embodiment 4 is significantly more than having for comparative example 4 compared with comparative example 4, using the efficiently individual quantity of the toothpaste of embodiment 4
Effect number, therapeutic effect is obvious, and in embodiment 4, gypsum accounting in Chinese medicine composition is 40%.So as to obtain, Chinese medicine
In composition, by mass percentage, gypsum is lower than 40%, and therapeutic effect is decreased obviously.
5. embodiment 3 is significantly more than having for comparative example 5 compared with comparative example 5, using the efficiently individual quantity of the toothpaste of embodiment 3
Effect number, therapeutic effect is obvious, and in embodiment 3, keel accounting in Chinese medicine composition is 10%.So as to obtain, Chinese medicine
In composition, by mass percentage, keel are lower than 10%, and therapeutic effect is decreased obviously.
6. embodiment 4 is significantly more than having for comparative example 6 compared with comparative example 6, using the efficiently individual quantity of the toothpaste of embodiment 4
Effect number, therapeutic effect is obvious, and in embodiment 4, keel accounting in Chinese medicine composition is 35%.So as to obtain, Chinese medicine
In composition, by mass percentage, keel are higher than 35%, and therapeutic effect is decreased obviously.
7. embodiment 1, compared with comparative example 7, the efficiently individual quantity using the toothpaste of embodiment 1 is obviously more, and comparative example 7
Efficiently individual quantity be 6.It can thus be seen that Chinese medicine composition of the invention has apparent therapeutic effect to canker sore.
In conjunction with conclusion 1-6 it can be concluded that, by weight percentage, Poria cocos 5%~25%；Gypsum 40%~80%；Keel
10%~35% can reach preferably effect.
8. embodiment 5, embodiment 6 are compared with Example 1, efficiently individual quantity is more than the efficiently individual quantity in embodiment 1, and implements
It joined gypsum rubrum in the raw material of example 5, joined stone swallow in embodiment 6, so as to obtain, gypsum rubrum, stone are added in raw material
Swallow can improve therapeutic effect respectively.
9. embodiment 7 is compared with Example 1, efficiently individual quantity is more than the efficiently individual quantity in embodiment 1, and the original of embodiment 7
It joined gypsum rubrum and stone swallow in material, so as to obtain, gypsum rubrum, stone swallow, which is added, can improve therapeutic effect simultaneously in raw material.
Furthermore embodiment 7 is respectively compared with embodiment 5, embodiment 6, and efficiently individual quantity is than the efficiently individual quantity in embodiment 5, embodiment 6
It is more, and joined gypsum rubrum and stone swallow in the raw material of embodiment 7, embodiment 5 only joined gypsum rubrum, and embodiment 6 only joined
The therapeutic effect of gypsum rubrum and stone swallow is added more preferably simultaneously in raw material so as to obtain in stone swallow.
10. embodiment 10 is with compared with Example 1, efficiently individual quantity is more than the efficiently individual quantity in embodiment 1, and embodiment 7
Chinese medicine composition in, the weight percent of each component is as follows: Poria cocos 15%；Gypsum 60%；Keel 25%, so as to
Out, the traditional Chinese medicine composition for treating better effect of aforementioned proportion.
Experiment 2
A kind of Clinical efficacy of the toothpaste containing Chinese medicine composition in terms for the treatment of gingivitis
This experiment is tested using the toothpaste of embodiment 10.
One, experimental method
1. observation object: outpatient service periodontosis go to a doctor patient 155, patient's concrete condition such as such as table 2.
Table 2
2. application method: the granting in the form of medicated toothpaste.
3. observation method: carrying out periodontal inspection before treatment, and record grow permanent teeth position, subjective symptoms, gingival index and bacterial plaque
Index.Above subject does conventional clean one's teeth.Deactivate antibiotic, external drug and other toothpaste.It brushes teeth once in the morning and once at night, every time
3 minutes or more.Check in 7-14 days is primary, fills in a form by These parameters.
4. observed content: subjective sensation, including bleeding of brushing teeth, hematostaxis, halitosis, irritation pain, gingival index, bacterium
Spot index.Observing time is 1 year.
Two, result (table 3) is observed:
Table 3
Compare conclusion:
The significance test for treating plaque effect: treating plaque 56 altogether, is compared t individually and examined, t=4.152,
> t0.001 (55)=3.478, P < 0.001.
Total effective rate 84.9%, pretherapy and post-treatment plaque index differ highly significant, illustrate to treat canker sore and gingivitis
Toothpaste can effectively reduce plaque and oral bacteria, and not bleeding or bleeding mitigate after brushing teeth.
What has been described above is only an embodiment of the present invention, and the common sense such as well known specific structure and characteristic are not made herein in scheme
Excessive description.It, without departing from the structure of the invention, can be with it should be pointed out that for those skilled in the art
Several modifications and improvements are made, these also should be considered as protection scope of the present invention, these all will not influence what the present invention was implemented
Effect and patent practicability.The scope of protection required by this application should be based on the content of the claims, in specification
The records such as specific embodiment can be used for explaining the content of claim.
Claims (10)
1. a kind of Chinese medicine composition for treating mouth disease, which is characterized in that be uniformly mixed by following components in percentage by weight
It is made: Poria cocos 5%~25%；Gypsum 40%~80%；Keel 10%~35%.
2. a kind of Chinese medicine composition for treating mouth disease according to claim 1, which is characterized in that the Poria cocos
15%；Gypsum 60%；Keel 25%.
3. a kind of Chinese medicine composition for treating mouth disease, which is characterized in that be uniformly mixed by following components in percentage by weight
It is made: Poria cocos 5%~25%；Gypsum 40%~80%；Keel 10%~35%；Gypsum rubrum 0.1%~5%.
4. a kind of Chinese medicine composition for treating mouth disease according to claim 3, which is characterized in that the gypsum rubrum is
3%.
5. a kind of Chinese medicine composition for treating mouth disease, which is characterized in that be uniformly mixed by following components in percentage by weight
It is made: Poria cocos 5%~25%；Gypsum 40%~80%；Keel 10%~35%；Gypsum rubrum 0.1%~5%；Stone swallow 0.1%~
10%.
6. a kind of Chinese medicine composition for treating mouth disease according to claim 5, which is characterized in that the stone swallow is
6%.
7. a kind of Chinese medicine composition for treating mouth disease described according to claim 1 or 2 or 3 or 4 or 6, which is characterized in that
The Poria cocos is Poria cocos powder or tuckahoe extracts, and the granularity of the Poria cocos powder is more than 180 mesh.
8. the oral-cavity article of the Chinese medicine composition containing any one of claims 1 or 22 or 3 or 4 or 6, which is characterized in that further include
Matrix, the matrix include moisturizer, rubbing agent, thickener, surfactant, sweetener, preservative and fragrance regulator, remaining
Amount is water.
9. oral-cavity article according to claim 8, which is characterized in that oral-cavity article is tooth gel, tooth paste or cream
One of shape preparation.
10. the preparation method of oral-cavity article according to claim 9, which comprises the steps of:
Moisturizer is added, adds thickener and stirs evenly；
Sweetener, preservative, surfactant is added and stirs evenly；
Chinese medicine composition is added, is sufficiently stirred；
Rubbing agent and water are added, fragrance regulator is stirring evenly and then adding into, is sufficiently stirred；
Vacuum outgas, cream processed are completed.
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| CN107349145B (en) * | 2017-06-27 | 2020-07-07 | 梅州市和谐生物科技有限公司 | Toothpaste helpful for treating gingival bleeding and preparation method thereof |
| CN109044895A (en) * | 2017-12-26 | 2018-12-21 | 李文婷 | A kind of anti-allergic oral-cavity care agent |
| CN108143758A (en) * | 2018-01-04 | 2018-06-12 | 孙永兴 | A kind of Chinese medicine composition for dental disorder |
| CN113398040A (en) * | 2021-08-07 | 2021-09-17 | 兰州市食品药品检验检测研究院 | Mouthwash as well as preparation method and use method thereof |
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| 中国使用牙刷考;宋红;《口腔护理用品工业》;20110630;第21卷(第3期);43-48 |
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| Publication number | Publication date |
|---|---|
| CN104983752A (en) | 2015-10-21 |
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