CN106138721A - A kind of external application Chinese medicine compound preparation treating recurrent oral ulceration and preparation method - Google Patents
A kind of external application Chinese medicine compound preparation treating recurrent oral ulceration and preparation method Download PDFInfo
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- CN106138721A CN106138721A CN201510420674.1A CN201510420674A CN106138721A CN 106138721 A CN106138721 A CN 106138721A CN 201510420674 A CN201510420674 A CN 201510420674A CN 106138721 A CN106138721 A CN 106138721A
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Abstract
The invention discloses a kind of external application Chinese medicine compound preparation treating recurrent oral ulceration, be made up of the raw material of following parts by weight: Galla Chinensis 3～7 parts, Indigo Naturalis 3～7 parts, Alumen 3～7 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3～7, Gypsum Fibrosum Preparatum 3～7 parts, Borneolum Syntheticum 1～2 parts.The invention also discloses the preparation method of this external application Chinese medicine compound preparation.Toxic and side effects of the present invention is little, can be used for treating recurrent oral ulceration；The present invention is strong to recurrent oral ulceration analgesic effect, and has promotion ulcer surface Healing；The common easy acquisition of Chinese medicine preparation of the present invention, preparation method is simple and easy to do；External preparation of the present invention can be used for treating recurrent oral ulceration and curative effect is preferable.
Description
Technical field
The present invention relates to a kind of external application Chinese medicine compound preparation and preparation method, particularly one are used for treating recurrence
The external application Chinese medicine compound preparation of property oral ulcer and preparation method.
Background technology
Recurrent oral ulceration, also known as recurrent aphthous ulcer, is modal oral keritonocytes, and it sticks
Film disease damage shows as that isolate, circular or oval skin ulcer, and its main discomfort is violent scorching hot
Pain, has a strong impact on patients diet and emotion, reduces patients ' life quality.Epidemiological study shows people
10%～the 25% of group suffers from this disease, and has periodicity, the feature of recurrent.
Modern medicine thinks that primary disease is relevant with inflammation, immunologic function disorder etc., but there is no the specially good effect for the treatment of primary disease
Therapy.The immunity such as clinical conventional 0.1% triamcinolone ointment, ring phosphorus phthalein amine, first ammonia butterfly cry of certain animals, azathioprine press down
Preparation reduces inflammation reaction, and the analgesic drug product such as lidocaine gel, spray and Lotion-Jel alleviates pain
Bitterly.But immunosuppressant has bone marrow depression, renal function injury, granulocytopenia or even pancytopenia
Deng untoward reaction, analgesic drug product is also only capable of when pain is extremely serious using, to avoid addiction.
Recurrent oral ulceration belongs to Chinese medicine " aphtha " category, the many uses of external treatment with Chinese medicine contain Borax, Calculus Bovis,
The Chinese medicine formula of the compositions such as calamitas urinae hominis, such as BINGPENG SAN, XILEI SAN, or the compound recipe mixed with dexamethasone hormone
Preparation.In the traditional Chinese medical science, Zhiduo County uses invigorating the spleen to clear away damp pathogen, heat-clearing and detoxifying herb decoction.But the Borax that external treatment compound recipe is conventional
Toxicity is higher, and permucosal absorption has multi viscera retention toxicosis dangerous, and Calculus Bovis is expensive, and calamitas urinae hominis is difficult to
Obtain；Treatment by oral administration of medicines decoction onset is slow, and taste is pained, and interior external treatment is all unable to reach quickly easing pain, raising
The purpose of patients ' life quality.
Summary of the invention
Goal of the invention: for problems of the prior art, it is an object of the invention to provide a kind for the treatment of
The external preparation of oral ulcer, preferably recurrent oral ulceration, to realizing being realized by local topical administration
Quickly easing pain, promotion oral ulcer healing；It is another object of the present invention to provide one to prepare this external
The preparation method of preparation.
Technical scheme: for achieving the above object, the technical solution used in the present invention is:
One treats oral ulcer, preferably the external application Chinese medicine compound preparation of recurrent oral ulceration, is by following
The raw material composition of parts by weight: Galla Chinensis 3～7 parts, Indigo Naturalis 3～7 parts, Alumen 3～7 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3～7 parts,
Gypsum Fibrosum Preparatum 3～7 parts, Borneolum Syntheticum 1～2 parts.
Preferably, it is made up of the raw material of following parts by weight: Galla Chinensis 5～7 parts, Indigo Naturalis 5～7 parts, in vain
Vitriol 5～7 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5～7 parts, Gypsum Fibrosum Preparatum 5～7 parts, Borneolum Syntheticum 1～2 parts.
Preferably, it is made up of the raw material of following parts by weight: Galla Chinensis 5 parts, Indigo Naturalis 5 parts, Alumen 5
Part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Gypsum Fibrosum Preparatum 5 parts, Borneolum Syntheticum 2 parts.
In inventive formulation, Galla Chinensis is cold in nature, sour in the mouth, puckery, pathogenic fire reducing of astringing the lung, removing dampness sore；Indigo Naturalis is cold in nature,
Salty in the mouth, heat-clearing and toxic substances removing, removing heat from blood pathogenic fire purging；Borneolum Syntheticum cold nature, acrid in the mouth, hardship, heat-clearing and toxic substances removing；Gypsum Fibrosum Preparatum is cold in nature,
Sweet in the mouth, pungent, puckery, removing dampness granulation promoting, sore；The Pseudobulbus Bletillae (Rhizoma Bletillae) is cold in nature, bitter in the mouth, sweet, puckery, astringing to arrest bleeding, detumescence
Granulation promoting；Alumen is cold in nature, puckery, and detoxify parasite killing, and dampness is stopped blooding.The most each medicine compatibility external, has heat clearing away
Removing toxic substances, removing heat from blood pathogenic fire purging, the effect of removing dampness sore, reach to ease pain rapidly, wound healing effect.
Preparation of the present invention is powder.
One prepares the method for the external application Chinese medicine compound preparation for the treatment of oral ulcer, preferably recurrent oral ulceration:
Galla Chinensis, Indigo Naturalis, Alumen, the Pseudobulbus Bletillae (Rhizoma Bletillae), Gypsum Fibrosum Preparatum are individually ground into 100 mesh fine powders；Borneolum Syntheticum is individually ground
Pulverizing is broken into 100 mesh fine powders；By by the Galla Chinensis of above-mentioned weight proportion, Indigo Naturalis, Alumen, the Pseudobulbus Bletillae (Rhizoma Bletillae), Calx
Cream, Borneolum Syntheticum mix homogeneously, be preferably disposed in lucifuge vial preservation.
Beneficial effect: compared with prior art, the remarkable advantage of the present invention is: this compound Chinese medicinal preparation is by often
Forming with pure Chinese medicine, toxic and side effects is little；The external preparation of the present invention is via local a small amount of medication, about half a minute
I.e. pain relieving, ulcer surface healing in 3-5 days, hence it is evident that be better than the most visible Chinese patent medicine；Chinese medicine used by the present invention
Be easily obtained, cheap, there is higher clinical expansion.
Inventive formulation has heat-clearing and toxic substances removing, removing heat from blood pathogenic fire purging, the effect of removing dampness sore, it is adaptable to recurrent oral is burst
The treatment of infections.The present invention by clinical research demonstrate its can alleviate rapidly to recurrent oral ulceration pain,
Shorten ulcer surface healing time, determined curative effect.
Figure of description
Fig. 1: A is that case 1 treats front photo；B is photo (black arrow show at mucosal ulcer) after treatment.
Fig. 2: A is that case 2 treats front photo；B is photo (black arrow show at mucosal ulcer) after treatment.
Fig. 3: A is that case 3 treats front photo；B is photo (black arrow show at mucosal ulcer) after treatment.
Fig. 4: A is that case 4 treats front photo；B is photo (black arrow show at mucosal ulcer) after treatment.
Fig. 5: A is that case 5 treats front photo；B is photo (black arrow show at mucosal ulcer) after treatment.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.It should be pointed out that, for this area
For those of ordinary skill, under the premise without departing from the principles of the invention, it is also possible to make some deformation and change
Entering, these also should be regarded as belonging to protection scope of the present invention.
Embodiment 1
1. clinical data
1.1 diagnostic criteria
Complete with reference to first third time of stomatology meeting diseases of oral mucosa Professional Committee of in December, 2000 China
Know from experience " recurrent aphthous ulcer therapeutic evaluation tentative standard " formulation that view is passed through.Whole body therapeutic: at least
There are 2 pathogenic process of re current histories, and medical history more than 1 year；Ulcer is monthly shown effect more than 1 time.
Local treatment: ulcer time of origin was less than 48 hours.
1.2 inclusive criteria
Meet above-mentioned diagnostic criteria person, before going to a doctor, do not make any treatment；Happening part all at cheek or Mucosa of lip,
Quantity and differing in size；Ulcer is rounded or oval depressions, and surface covers canescence pseudomembrane, and surrounding is congested,
There is slight burn feeling local.
1.3 exclusion standard
Local treatment: heavy recurrent oral ulceration, Behcet disease；Systemic disease background: anemia, digestion
Property ulcer, clone disease, acute infectious diseases, autoimmune disease etc.；Analgesia is used in 24 hours
Medicine, uses antibiotic, antibiotic medicine in January, in March, whole body uses corticosteroid, immunosuppressant；3
Smoker, alcoholic in month；Tumor patient.Whole body therapeutic: pregnancy women, remaining is with local treatment.
1.4 physical data
According to case diagnosis, include in and exclusion standard collect Blood of Patients with Recurrent Oral 80 example.Use with
Machine digits table is divided into Chinese drug-treated group 40 example, matched group 40 example.Chinese drug-treated group man's 18 examples, female 22 example；Age
22～45 years old, average (32.51 ± 4.32) year；The course of disease 2～5 years, average (3.32 ± 1.21) year.Comparison
Organize male 21 examples, female 19 example；Age 23～46 years old, average (31.42 ± 3.35) year；The course of disease 2～5 years,
Averagely (3.15 ± 1.15) year.Each group patient's physical data comparing difference not statistically significant (P ＞ 0.05).
2 methods
2.1 Therapeutic Method
Chinese drug-treated group: give recurrent oral ulceration Chinese medicine external compound recipe.Preparation process: by Galla Chinensis 50g, green grass or young crops
Black pigment used by women in ancient times to paint their eyebrows 50g, Alumen 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 50g, Gypsum Fibrosum Preparatum 50g are individually ground into 100 mesh fine powders；By Borneolum Syntheticum 20g
Individually grounds travel is broken into 100 mesh fine powders；By 5: 5: 5: the weight proportion of 5: 5: 2 will be added medicine to mix homogeneously, be placed in and keep away
Light vial preserves.Chinese medicine is purchased from Changping District, Beijing hospitals of traditional Chinese and western medicine Chinese medicine pharmacy.During use
Taking appropriate medicated powder and be externally applied to ulcer surface, three times a day, 30min fasting water after taking medicine, continuous use is to ulcer
Heal completely in face.
Matched group: do not carry out pharmaceutical intervention.
2.2 observation index and method
From beginning medication the 1st day, heal completely to ulcer surface, every day entry canker sores integration.Reference
" recurrent aphthous ulcer therapeutic evaluation tentative standard ", uses Visual analogue scale to evaluate pain degree, i.e.
Using the straight line of 10cm, 0 end of straight line represents " painless ", and 10cm end represents " the most violent pain ",
Patient is different according to the level of sensitivity of pain, and the corresponding scale at straight line is noted down.
When starting medication the 1st day and ulcer surface heals completely, is taken pictures in ulcer local, record ulcer healing
Required natural law.
2.3 efficacy determination
With reference to the local treatment the standard of curative effect evaluation in " recurrent aphthous ulcer therapeutic evaluation tentative standard "
-DP staging.I.e. D1-average ulcerative stage shortens (t checks, P ＜ 0.05)；D0-average ulcerative stage is without changing
Become (t checks, P ＞ 0.05)；P1-pain index reduces (t checks, P ＜ 0.05), P0-pain index is without changing
Become (t checks, P ＞ 0.05).
Through treatment after effective: D1P1；Effective: D1P0Or D0P1；Invalid: D0P0, total effective rate=obvious effective rate
+ effective percentage.
2.4 statistical method
SPSS17.0 software is used to carry out data statistic analysis.Measurement data is with mean ± standard deviationRepresent.
Compare employing independent samples t test between two groups, between many groups, compare employing variance analysis.Compare between many groups and have
Difference need to not compare person two-by-two, and variance uses SNK to check together；Heterogeneity of variance uses Dunnett ' s T3 inspection.
If measurement data disobeys normal distribution, then represent with median.Employing rank test is compared between group.With generally
Rate value P show difference (P ＜ 0.05 is that difference is statistically significant, P ＞ 0.05 not statistically significant).
3 results
3.1 Chinese drug-treated group compare with matched group pain total mark
As table 1 shows, comparing with matched group, the pain in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease is always amassed
Clearly demarcated aobvious reduction, difference statistically significant (P ＜ 0.05).
Table 1 Chinese drug-treated group and matched group pain total mark table
* compare with matched group, P ＜ 0.05
3.2 Chinese drug-treated group compare with matched group healing
As table 2 shows, compare with matched group, the ulcer healing in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease
Time substantially shortens, difference statistically significant (P ＜ 0.05).
Table 2 Chinese drug-treated group and matched group healing table
* compare with matched group, P ＜ 0.05
3.3 Chinese drug-treated group total effective rates
As table 3 shows, Chinese drug-treated group Blood of Patients with Recurrent Oral effective case 36 example, obvious effective rate 90%；Effectively
4 cases, effective percentage 10%；Ineffective Cases 0 example；Total effective rate 100%.
Table 3 Chinese drug-treated group total effective rate
Conclusion
Recurrent oral ulceration Chinese medicine external compound preparation in the present invention can substantially alleviate the pain in patient's course of disease
Degree bitterly, and promote ulcer healing, shorten the course of disease, this compound Chinese medicinal preparation determined curative effect.
Embodiment 2
Case 1 Lee, man, 26 years old, recurrent exerbation oral ulcer 2 years, this newly sent out oral ulcer, bursts
Cave in infections face, oval Semen phaseoli radiati grain size, " the more skin ulcer dissipates " local application prepared with the embodiment of the present invention 1,
Within after medication 35 seconds, relieve the pain, day coating 3 times, within 2 days, pain disappears substantially, recovery from illness in 3 days.Fig. 1 is seen before and after treatment.
Embodiment 3
Case 2 Dong, female, 31 years old, recurrent exerbation oral ulcer 3 years, this newly sent out oral ulcer, altogether
Ulcer surface at 1, area about 7mm × 4mm, it is coated with " more skin ulcer dissipates " local that the embodiment of the present invention 1 prepares
Medicine, coating relieved the pain after 20 seconds, day coating 3 times, within 2 days, pain disappears substantially, recovery from illness in 5 days.Before and after treatment
See Fig. 2.
Embodiment 4
Case 3 bent certain, female, 31 years old, recurrent exerbation oral ulcer 5 years, this newly sent out oral ulcer, single
Place's oral ulcer area small rice grain size, " the more skin ulcer dissipates " local application prepared with the embodiment of the present invention 1,
Coating relieved the pain after 15 seconds, day coating 3 times, within 3 days, pain disappears substantially, recovery from illness in 3 days.Figure is seen before and after treatment
3。
Embodiment 5
Repeat the experiment of embodiment 1, except recurrent oral ulceration Chinese medicine external compound recipe is as follows: by Galla Chinensis
30g, Indigo Naturalis 30g, Alumen 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Gypsum Fibrosum Preparatum 30g are individually ground into 100 mesh fine powders；By ice
The independent grounds travel of sheet 10g is broken into 100 mesh fine powders；By 3: 3: 3: the weight proportion of 3: 3: 1 will be added medicine to mix homogeneously,
It is placed in lucifuge vial preservation.Chinese medicine is purchased from Changping District, Beijing hospitals of traditional Chinese and western medicine Chinese medicine pharmacy.
Take appropriate medicated powder during use and be externally applied to ulcer surface, three times a day, 30min fasting water, continuous use after taking medicine
Heal completely to ulcer surface.
Experimental result is as follows:
As table 4 shows, comparing with matched group, the pain in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease is always amassed
Clearly demarcated aobvious reduction, difference statistically significant (P ＜ 0.05).
Table 4 Chinese drug-treated group and matched group pain total mark table
* compare with matched group, P ＜ 0.05
Chinese drug-treated group compares with matched group healing
As table 5 shows, compare with matched group, the ulcer healing in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease
Time substantially shortens, difference statistically significant (P ＜ 0.05).
Table 5 Chinese drug-treated group and matched group healing table
* compare with matched group, P ＜ 0.05
Chinese drug-treated group total effective rate
As table 6 shows, Chinese drug-treated group Blood of Patients with Recurrent Oral effective case 34 example, obvious effective rate 85%；Effectively
Case 6 example, effective percentage 15%；Ineffective Cases 0 example；Total effective rate 100%.
Table 6 Chinese drug-treated group total effective rate
Embodiment 6
Case 3 Lu, female, 27 years old, recurrent exerbation oral ulcer 4 years, this newly sent out oral ulcer, single
Place's oral ulcer area Semen phaseoli radiati size, on the right side of tongue body, " more skin ulcer dissipates " prepared with the embodiment of the present invention 5
Local application, coating relieved the pain after 20 seconds, day coating 3 times, within 3 days, pain disappears substantially, recovery from illness in 4 days.Control
Fig. 4 is seen before and after treatment.
Embodiment 7
Repeat the experiment of embodiment 1, except recurrent oral ulceration Chinese medicine external compound recipe is as follows: by Galla Chinensis
70g, Indigo Naturalis 70g, Bai Fan 70g, Pseudobulbus Bletillae (Rhizoma Bletillae) 70g, Gypsum Fibrosum Preparatum 70g are individually ground into 100 mesh fine powders；By ice
The independent grounds travel of sheet 20g is broken into 100 mesh fine powders；By 7: 7: 7: the weight proportion of 7: 7: 2 will be added medicine to mix homogeneously,
It is placed in lucifuge vial preservation.Chinese medicine is purchased from Changping District, Beijing hospitals of traditional Chinese and western medicine Chinese medicine pharmacy.
Take appropriate medicated powder during use and be externally applied to ulcer surface, three times a day, 30min fasting water, continuous use after taking medicine
Heal completely to ulcer surface.
Experimental result is as follows:
As table 7 shows, comparing with matched group, the pain in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease is always amassed
Clearly demarcated aobvious reduction, difference statistically significant (P ＜ 0.05).
Table 7 Chinese drug-treated group and matched group pain total mark table
* compare with matched group, P ＜ 0.05
Chinese drug-treated group compares with matched group healing
As table 8 shows, compare with matched group, the ulcer healing in the Chinese drug-treated group Blood of Patients with Recurrent Oral course of disease
Time substantially shortens, difference statistically significant (P ＜ 0.05).
Table 8 Chinese drug-treated group and matched group healing table
* compare with matched group, P ＜ 0.05
Chinese drug-treated group total effective rate
As table 9 shows, Chinese drug-treated group Blood of Patients with Recurrent Oral effective case 37 example, obvious effective rate 92.5%；Have
Effect case 3 example, effective percentage 7.5%；Ineffective Cases 0 example；Total effective rate 100%.
Table 9 Chinese drug-treated group total effective rate
Embodiment 8
Case 5 Wang, female, 32 years old, recurrent exerbation oral ulcer 6 years, this newly sends out at oral ulcer 1,
It is positioned at right side tongue body, area about 1.5mm × 2mm, " the more skin ulcer dissipates " office prepared with the embodiment of the present invention 7
Portion's coating, coating relieved the pain after 25 seconds, day coating 3 times, within 2 days, pain disappears substantially, recovery from illness in 4 days.Treatment
Front and back see Fig. 5.
Claims (8)
1. treat the external application Chinese medicine compound preparation of oral ulcer, it is characterised in that be by the raw material group of following parts by weight
Become: Galla Chinensis 3-7 part, Indigo Naturalis 3-7 part, Alumen 3-7 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-7 part, Gypsum Fibrosum Preparatum 3-7 part,
Borneolum Syntheticum 1-2 part.
2. the as claimed in claim 1 external application Chinese medicine compound preparation treating oral ulcer, it is characterised in that be by under
The raw material composition of row parts by weight: Galla Chinensis 5-7 part, Indigo Naturalis 5-7 part, Alumen 5-7 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7
Part, Gypsum Fibrosum Preparatum 5-7 part, Borneolum Syntheticum 1-2 part.
3. the as claimed in claim 1 external application Chinese medicine compound preparation treating oral ulcer, it is characterised in that be by under
The raw material composition of row parts by weight: Galla Chinensis 5 parts, Indigo Naturalis 5 parts, Alumen 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Calx
Cream 5 parts, Borneolum Syntheticum 2 parts.
4. the external application Chinese medicine compound preparation of the treatment oral ulcer described in any one of claim 1-3, it is characterised in that
Described preparation is powder, or described oral ulcer is recurrent oral ulceration.
5. the method for preparation external application Chinese medicine compound preparation as described in any one of claim 1-4, including:
(1) Galla Chinensis, Indigo Naturalis, Alumen, the Pseudobulbus Bletillae (Rhizoma Bletillae), Gypsum Fibrosum Preparatum are individually ground into 100 mesh fine powders；
(2) independent for Borneolum Syntheticum grounds travel is broken into 100 mesh fine powders；
(3) by Galla Chinensis by weight ratio, Indigo Naturalis, Alumen, the Pseudobulbus Bletillae (Rhizoma Bletillae), Gypsum Fibrosum Preparatum, Borneolum Syntheticum mix homogeneously.
6. the method for claim 5, wherein said weight proportion is Galla Chinensis 5-7 part, Indigo Naturalis 5-7 part, Alumen
5-7 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part, Gypsum Fibrosum Preparatum 5-7 part, Borneolum Syntheticum 1-2 part.
7. the method for claim 6, wherein said weight proportion is Galla Chinensis 5 parts, Indigo Naturalis 5 parts, Alumen 5 parts,
The Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Gypsum Fibrosum Preparatum 5 parts, Borneolum Syntheticum 2 parts.
8. the method described in any one of claim 5-7, wherein by the Galla Chinensis of mix homogeneously, Indigo Naturalis, Alumen,
The Pseudobulbus Bletillae (Rhizoma Bletillae), Gypsum Fibrosum Preparatum, Borneolum Syntheticum are placed in lucifuge vial preservation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101351A (en) * | 2021-04-23 | 2021-07-13 | 刘齐贵 | Pharmaceutical formulations containing alum and methods for treating inflammatory and erosive skin and mucous membranes |
| CN115813981A (en) * | 2022-12-28 | 2023-03-21 | 珠海天大中医药研究开发有限公司 | Traditional Chinese medicine composition and medicine with functions of preventing and repairing oral ulcer and preparation method and application thereof |
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| CN101933959A (en) * | 2010-09-10 | 2011-01-05 | 韩守合 | Medicament for treating canker and preparation method thereof |
| CN104107335A (en) * | 2014-07-31 | 2014-10-22 | 周冠旻 | Traditional Chinese medicine composition for oral administration and external application for treating canker sore |
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2015
- 2015-07-17 CN CN201510420674.1A patent/CN106138721A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933959A (en) * | 2010-09-10 | 2011-01-05 | 韩守合 | Medicament for treating canker and preparation method thereof |
| CN104107335A (en) * | 2014-07-31 | 2014-10-22 | 周冠旻 | Traditional Chinese medicine composition for oral administration and external application for treating canker sore |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101351A (en) * | 2021-04-23 | 2021-07-13 | 刘齐贵 | Pharmaceutical formulations containing alum and methods for treating inflammatory and erosive skin and mucous membranes |
| CN115813981A (en) * | 2022-12-28 | 2023-03-21 | 珠海天大中医药研究开发有限公司 | Traditional Chinese medicine composition and medicine with functions of preventing and repairing oral ulcer and preparation method and application thereof |
| CN115813981B (en) * | 2022-12-28 | 2023-11-21 | 珠海天大中医药研究开发有限公司 | Traditional Chinese medicine composition and medicine with function of preventing and repairing dental ulcer, and preparation method and application thereof |
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Application publication date: 20161123 |