CN107714569A - A kind of preparation method of fragrant plant mouthwash - Google Patents
A kind of preparation method of fragrant plant mouthwash Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The present invention relates to a kind of preparation method of fragrant plant mouthwash, belong to health product technology field.In order to the phenomenon of sphagitis or cough symptom easily occur after overcoming mouthwash long-term use in the prior art, the present invention provides a kind of preparation method of fragrant plant mouthwash, it is the raw material based on fragrant plant, aromatic plant extract is obtained by way of the auxiliary distillation of suitable Microwave Extraction, chrysanthemum extract is obtained by supercritical extract, then aromatic plant extract and chrysanthemum extract are merged and in oleoptene, the green auxiliary material such as olive oil is mixed with to obtain fragrant plant mouthwash, the products taste is comfortable, aromatic odor is dense, it is and safe and non-toxic, it is adapted to long-term use.
Description
Technical field
The present invention relates to a kind of preparation method of fragrant plant mouthwash, belong to cosmetic technical field.
Background technology
Mouthwash can effectively reduce the quantity of pathogenic microorganisms in oral cavity, supplemented with mechanicalness control bacterial plaque method not
Foot.Gargle remove oral peculiar smell, reduce oral bacteria, prevent carious tooth, anti-inflammatory and antalgic in terms of have good effect, frequently as
The auxiliary treatment medicine of the mouth diseases such as periodontitis, gingivitis, pericoronitis, oral keritonocytes.These medicine gargle oral cavities
Nursing can effectively suppress bacterial plaque and be formed, and improve gingivitis situation.
In American-European countries, mouthwash has become the essential product of mouth cavity daily nursing.On European ＆ American Market, toothpaste and gargle
Ratio shared by saliva is equally matched.And in China, although gargle species is various, its market share is very low, and gargle
Preparation manufacturer and and core technology is mostly artificial external is occupied.Why gargle is difficult to develop in China, mainly there is 3 sides
The reason for face:(1) restricted by economic condition, Chinese are not also very high to the acceptance of gargle, and oral cavity is protected in abstracto
The attention degree of reason need to be improved；(2) characteristic is lacked on publicity is promoted, promotion method also using present or is used as bundle sale
Mode based on；(3) normalization in gargle market.Many producers domestic at present exist in sales process excessively exaggerates medical treatment
The problem of, this causes the market confusion of domestic gargle and development difficult to a certain extent.
The mouthwash of existing market contains alcohol or chlorohexidene class material more, and this kind of mouthwash mouthfeel is pepperyyer, long-term use of
Certain harm be present to the health of people, and Chinese traditional herbs class mouthwash forms so that the pure Chinese herbal medicine of medicine-food two-purpose class is refined
, its main component elscholtiza, cloves etc., and the not broad-spectrum disinfectant such as spirituosity sterilization class chemical analysis, contain Traditional Chinese Medicine culture
Characteristic, no matter old man or child can feel at ease to use.But there is the unstable skill of effect in existing Chinese herbal medicine class mouthwash
Art deficiency, based on this, the present invention provides a kind of comfortable taste, the fragrant plant mouthwash that bactericidal effect protrudes.
2015103584108 disclose a kind of fragrant antiemetic mouthwash and preparation method thereof, and the mouthwash is in terms of mass parts
Contain following component：5~14 parts of ethanol, 1~5 part of inositol hexaphosphate, 0.1~0.5 part of anacardol, fennel oil 0.6~2.5
Part, 0.8~4.5 part of polyoxyethylene octadecanol, 0.45~1.3 part of ADSP, 0.2~0.8 part of dipotassium glycyrrhizinate,
4~13 parts of sodium carboxymethylcellulose, 0.6~1.4 part of CALCIUM CHLORIDE DIHYDRATE, 0.02~0.07 part of urea peroxide, methyl hydroxybenzoate
0.01~0.05 part, 0.4~1.4 part of lysozyme chloride, 0.05~0.12 part of chlorohexidene, 85~100 parts of water, Amomum cardamomum 3~10
Part, 2~8 parts of tsaoko, 1~6 part of aster.Mouthwash provided by the invention has fresh breath, kills the effect of oral bacteria, together
When, going back mouthwash also has the function that dampness elimination promoting the circulation of qi, warming middle energizer to stop vomiting.
201610073551X discloses a kind of fragrant bacteriostatic mouthwash, includes according to the raw material of parts by weight：Water 80-100
Part, ethanol 10-15 parts, peony extract concentrate 10-12 parts, scutellaria water extract 8-12 parts, coptis water extract 5-10 parts, hook
Rattan 50wt% ethanol water extract 5-10 parts, shell of areca nut ethanol extract 6-8 parts, NMF 6-8 parts, product Dulcis ethanol extracts
4-6 parts, leaf of negundo chastetree 50wt% ethanol water extract 3-5 parts, complete sodium carboxymethylcellulose pyce 3-5 parts, inositol hexaphosphate 2-4 parts, radix glycyrrhizae
Sour dipotassium 0.4-0.6 parts, anacardol 0.3-0.5 parts, flavouring 0.1-0.2 parts, preservative 0.1-0.2 parts, the flavouring are
FOS.The present invention not only has the function that stronger reduction oral microorganism ability, degerming anti-inflammatory and except halitosis, and has
There are the natural scents of peony, there is very strong inhibitory action to Escherichia coli and staphylococcus aureus, to above-mentioned strain
Inhibiting rate all more than 85%, safety, can be long-term use of.
The content of the invention
In order to overcome the long-term use of harm of mouthwash in the prior art larger, the poor technical deficiency of mouthfeel, the present invention carries
For a kind of preparation method of fragrant plant mouthwash, it is the raw material based on fragrant plant, auxiliary by suitable Microwave Extraction
Help the mode of distillation to obtain aromatic plant extract, chrysanthemum extract is obtained by supercritical extract, then carried fragrant plant
Liquid and chrysanthemum extract is taken to be incorporated in the green auxiliary material such as oleoptene, olive oil and be mixed with to obtain fragrant plant mouthwash, the production
Product can effectively prevent the throat discomfort symptom of user, and safe and non-toxic, be adapted to long-term use.
The present invention is achieved through the following technical solutions above-mentioned technique effect：
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:0.8-1.6:4-8 ratio is mixed to prepare aromatic plant powder, and it is added to aromatic plant powder
The purified water of 5 times of volumes of quality, is placed in Microwave Extraction device, and it is 350W-500W to control Microwave Extraction power, continuous extraction
Extract solution is transferred in boiler after 15-25min, computer heating control distillation kettle temperature is 55-69 DEG C, and distillation pot inner pressure is
2-3Kpa, continuous still 1-1.5h, temperature is increased to 150-160 DEG C, distillates fragrant plant oil-water mixture, by fragrant plant
Oil-water mixture is by condensing tube condensation, and the inlet temperature of condenser pipe is 150 DEG C, and outlet temperature is 70 DEG C, is then passed through
Oil water separator is separated, and obtains including the aromatic plant extract of essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 24-28MPa to set extraction kettle pressure, and temperature is 35-55 DEG C, extraction time 2-4h；Dissolved with extraction
The supercritical carbon dioxide fluid for going out thing successively enters separating still I and separating still II through pressure-reducing valve, and it is 6- to set the pressure of separating still I
8MPa, temperature are 44-48 DEG C, collect extract I；It is 4-5MPa to set the pressure of separating still II, and temperature is 32-34 DEG C, collects extraction
Take liquid II；Combining extraction liquid I and extract II obtain chrysanthemum extract；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 40-60 DEG C of vacuum drying 12-24 hour, crush, cross 60-80 mesh sieves,
Chrysanthemum powder adds distilled water and carries out refluxing extraction after sieving, and extraction conditions are that solid-liquid ratio is 1：10-1：20, Extracting temperature is
80-95 DEG C, extraction time is 60-90 minutes；Filtering, 15-20 minutes are centrifuged by filtrate under the conditions of 10000-12100g；Then
Filtered again using filter paper, filtrate is concentrated into the 40-50% of original volume, and concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract
4-5 parts, chrysanthemum extract 6-8 parts, pseudo-ginseng extract solution 3-5 parts, 2 parts -3 parts of Tween 80,0.05 part -2 parts of FOS, glycerine 4
Part -6 parts, P-hydroxybenzoic acid sodium 0.01-0.2 parts, tea oil 3.5-5.5 parts, purified water 600-800 parts are abundant by each raw material
Stir, 121 DEG C of sterilizing 20min, be cooled to packing after room temperature and can obtain fragrant plant mouthwash.
Preferably, the step 1）Herba Menthae powder, honeysuckle powder and thyme powder mass ratio are 1 in middle aromatic plant powder:
1.2:6。
Preferably, the step 1）Middle Microwave Extraction power is 450W, extraction time 20min.
Preferably, the step 1）Middle vapo(u)rizing temperature is 62 DEG C, distillation time 1h.
Preferably, the mass ratio of chrysanthemum powder and entrainer is 1 in the step 2)：4-6.
Preferably, the step 2）Middle extraction kettle pressure is 26MPa, and temperature is 45 DEG C, separated when extraction time is 3h
The active ingredient of obtained chrysanthemum is maximum.
Preferably, the step 2）The pressure of middle setting separating still I is 7MPa, and temperature is 46 DEG C；Separating still II is set to press
Power is 4.5MPa, and temperature is 33 DEG C.
The present invention has following technical advantage relative to prior art：
1）The present invention uses fragrant plant to extract aromatic oil for primary raw material, active component is extracted from chrysanthemum, and aid in it
His plant origin material, its is safe and non-toxic, long-term use of nonhazardous effect.
2）It can effectively lower during the preparation-obtained mouthwash use of the present invention or avoid user from producing throat
Phenomena such as uncomfortable, its compliance is strong, and audient's degree is high, can carry out popularization and application.
Embodiment
The present invention is further described below by way of specific embodiment, but the embodiment does not limit this hair in any way
The scope of bright patent protection.
A kind of preparation method of fragrant plant mouthwash of embodiment 1
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:0.8:4 ratio is mixed to prepare aromatic plant powder, and 5 times of its quality is added to aromatic plant powder
The purified water of volume, it is placed in Microwave Extraction device, it is 350W to control Microwave Extraction power, will extraction after continuous extraction 15min
Liquid is transferred in boiler, and computer heating control distillation kettle temperature is 55 DEG C, and distillation pot inner pressure is 2Kpa, continuous still 1h, is incited somebody to action
Temperature is increased to 150 DEG C, distillates fragrant plant oil-water mixture, cold by fragrant plant oil-water mixture by condensing tube condensation
The inlet temperature of solidifying pipe is 150 DEG C, and outlet temperature is 70 DEG C, is then separated it by oil water separator, comprising
The aromatic plant extract of essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 24MPa to set extraction kettle pressure, and temperature is 35 DEG C, extraction time 2h；It is super dissolved with extract
Critical carbon dioxide fluid successively enters separating still I and separating still II through pressure-reducing valve, and the setting pressure of separating still I is 6MPa, temperature
For 44 DEG C, extract I is collected；It is 4MPa to set the pressure of separating still II, and temperature is 32 DEG C, collects extract II；Combining extraction liquid I
Chrysanthemum extract is obtained with extract II；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 40 DEG C are dried in vacuo 12 hours, crush, and cross 60 mesh sieves, chrysanthemum after sieving
Powder adds distilled water and carries out refluxing extraction, and extraction conditions are that solid-liquid ratio is 1：10, Extracting temperature is 80 DEG C, extraction time 60
Minute；Filtering, filtrate is centrifuged 15 minutes under the conditions of 10000g；Then filtered again using filter paper, filtrate is concentrated into substance
Long-pending 40%, concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract 5
Part, 8 parts of chrysanthemum extract, 5 parts of pseudo-ginseng extract solution, 2 parts of Tween 80,0.05 part of FOS, 4 parts of glycerine, P-hydroxybenzoic acid
Sodium 0.01,3.5 parts of tea oil, 600 parts of purified water, each raw material is stirred, 121 DEG C of sterilizing 20min, be cooled to room temperature
Packing can obtain fragrant plant mouthwash afterwards.
A kind of preparation method of fragrant plant mouthwash of embodiment 2
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:1.6:8 ratio is mixed to prepare aromatic plant powder, and 5 times of its quality is added to aromatic plant powder
The purified water of volume, it is placed in Microwave Extraction device, it is 500W to control Microwave Extraction power, will extraction after continuous extraction 25min
Liquid is transferred in boiler, and computer heating control distillation kettle temperature is 69 DEG C, and distillation pot inner pressure is 3Kpa, continuous still 1.5h,
Temperature is increased to 160 DEG C, distillates fragrant plant oil-water mixture, by fragrant plant oil-water mixture by condensing tube condensation,
The inlet temperature of condenser pipe is 150 DEG C, and outlet temperature is 70 DEG C, and then it is separated by oil water separator, is wrapped
Aromatic plant extract containing essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 28MPa to set extraction kettle pressure, and temperature is 55 DEG C, extraction time 4h；It is super dissolved with extract
Critical carbon dioxide fluid successively enters separating still I and separating still II through pressure-reducing valve, and the setting pressure of separating still I is 8MPa, temperature
For 48 DEG C, extract I is collected；It is 5MPa to set the pressure of separating still II, and temperature is 34 DEG C, collects extract II；Combining extraction liquid I
Chrysanthemum extract is obtained with extract II；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 60 DEG C are dried in vacuo 24 hours, crush, and cross 80 mesh sieves, chrysanthemum after sieving
Powder adds distilled water and carries out refluxing extraction, and extraction conditions are that solid-liquid ratio is 1：20, Extracting temperature is 95 DEG C, extraction time 90
Minute；Filtering, filtrate is centrifuged 20 minutes under the conditions of 12100g；Then filtered again using filter paper, filtrate is concentrated into substance
Long-pending 50%, concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract 5
Part, 8 parts of chrysanthemum extract, 5 parts of pseudo-ginseng extract solution, 3 parts of Tween 80,2 parts of FOS, 6 parts of glycerine, P-hydroxybenzoic acid sodium
0.2 part, 5.5 parts of tea oil, 800 parts of purified water, each raw material is stirred, 121 DEG C of sterilizing 20min, be cooled to room temperature
Packing can obtain fragrant plant mouthwash afterwards.
A kind of preparation method of fragrant plant mouthwash of embodiment 3
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:1.2:6 ratio is mixed to prepare aromatic plant powder, and 5 times of its quality is added to aromatic plant powder
The purified water of volume, it is placed in Microwave Extraction device, it is 450W to control Microwave Extraction power, will extraction after continuous extraction 20min
Liquid is transferred in boiler, and computer heating control distillation kettle temperature is 62 DEG C, and distillation pot inner pressure is 2.5Kpa, continuous still
1.5h, is increased to 155 DEG C by temperature, distillates fragrant plant oil-water mixture, and fragrant plant oil-water mixture is passed through into condenser pipe
Condensation, the inlet temperature of condenser pipe is 150 DEG C, and outlet temperature is 70 DEG C, and then it is separated by oil water separator, is obtained
To the aromatic plant extract comprising essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 26MPa to set extraction kettle pressure, and temperature is 45 DEG C, extraction time 3h；It is super dissolved with extract
Critical carbon dioxide fluid successively enters separating still I and separating still II through pressure-reducing valve, and the setting pressure of separating still I is 7MPa, temperature
For 46 DEG C, extract I is collected；It is 4.5MPa to set the pressure of separating still II, and temperature is 33 DEG C, collects extract II；Merge extraction
Liquid I and extract II obtain chrysanthemum extract；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 50 DEG C are dried in vacuo 18 hours, crush, and cross 70 mesh sieves, chrysanthemum after sieving
Powder adds distilled water and carries out refluxing extraction, and extraction conditions are that solid-liquid ratio is 1：15, Extracting temperature is 88 DEG C, extraction time 75
Minute；Filtering, filtrate is centrifuged 18 minutes under the conditions of 11000g；Then filtered again using filter paper, filtrate is concentrated into substance
Long-pending 45%, concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract
4.5 parts, 7 parts of chrysanthemum extract, 4 parts of pseudo-ginseng extract solution, 2 parts -3 parts of Tween 80,1 part of FOS, 5 parts of glycerine, para hydroxybenzene
0.1 part of sodium formate, 4.5 parts of tea oil, 700 parts of purified water, each raw material is stirred, 121 DEG C of sterilizing 20min, cooling
Packing can obtain fragrant plant mouthwash after to room temperature.
A kind of preparation method of fragrant plant mouthwash of embodiment 4
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:1.6:4 ratio is mixed to prepare aromatic plant powder, and 5 times of its quality is added to aromatic plant powder
The purified water of volume, it is placed in Microwave Extraction device, it is 500W to control Microwave Extraction power, will extraction after continuous extraction 15min
Liquid is transferred in boiler, and computer heating control distillation kettle temperature is 69 DEG C, and distillation pot inner pressure is 2Kpa, continuous still 1.5h,
Temperature is increased to 150 DEG C, distillates fragrant plant oil-water mixture, by fragrant plant oil-water mixture by condensing tube condensation,
The inlet temperature of condenser pipe is 150 DEG C, and outlet temperature is 70 DEG C, and then it is separated by oil water separator, is wrapped
Aromatic plant extract containing essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 28MPa to set extraction kettle pressure, and temperature is 35 DEG C, extraction time 4h；It is super dissolved with extract
Critical carbon dioxide fluid successively enters separating still I and separating still II through pressure-reducing valve, and the setting pressure of separating still I is 6MPa, temperature
For 48 DEG C, extract I is collected；It is 4MPa to set the pressure of separating still II, and temperature is 34 DEG C, collects extract II；Combining extraction liquid I
Chrysanthemum extract is obtained with extract II；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 40 DEG C are dried in vacuo 24 hours, crush, and cross 60 mesh sieves, chrysanthemum after sieving
Powder adds distilled water and carries out refluxing extraction, and extraction conditions are that solid-liquid ratio is 1：20, Extracting temperature is 80 DEG C, extraction time 90
Minute；Filtering, filtrate is centrifuged 20 minutes under the conditions of 10000g；Then filtered again using filter paper, filtrate is concentrated into substance
Long-pending 40%, concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract 5
Part, 6 parts of chrysanthemum extract, 5 parts of pseudo-ginseng extract solution, 2 parts of Tween 80,2 parts of FOS, 4 parts of glycerine, P-hydroxybenzoic acid sodium
0.2 part, 3.5 parts of tea oil, 800 parts of purified water, each raw material is stirred, 121 DEG C of sterilizing 20min, be cooled to room temperature
Packing can obtain fragrant plant mouthwash afterwards.
A kind of preparation method of fragrant plant mouthwash of embodiment 5
A kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:0.8:8 ratio is mixed to prepare aromatic plant powder, and 5 times of its quality is added to aromatic plant powder
The purified water of volume, it is placed in Microwave Extraction device, it is 350W to control Microwave Extraction power, will extraction after continuous extraction 25min
Liquid is transferred in boiler, and computer heating control distillation kettle temperature is 55 DEG C, and distillation pot inner pressure is 3Kpa, continuous still 1h, is incited somebody to action
Temperature is increased to 160 DEG C, distillates fragrant plant oil-water mixture, cold by fragrant plant oil-water mixture by condensing tube condensation
The inlet temperature of solidifying pipe is 150 DEG C, and outlet temperature is 70 DEG C, is then separated it by oil water separator, comprising
The aromatic plant extract of essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 24MPa to set extraction kettle pressure, and temperature is 55 DEG C, extraction time 2h；It is super dissolved with extract
Critical carbon dioxide fluid successively enters separating still I and separating still II through pressure-reducing valve, and the setting pressure of separating still I is 8MPa, temperature
For 44 DEG C, extract I is collected；It is 5MPa to set the pressure of separating still II, and temperature is 32 DEG C, collects extract II；Combining extraction liquid I
Chrysanthemum extract is obtained with extract II；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 60 DEG C are dried in vacuo 12 hours, crush, and cross 80 mesh sieves, chrysanthemum after sieving
Powder adds distilled water and carries out refluxing extraction, and extraction conditions are that solid-liquid ratio is 1：10, Extracting temperature is 95 DEG C, extraction time 60
Minute；Filtering, filtrate is centrifuged 15 minutes under the conditions of 12100g；Then filtered again using filter paper, filtrate is concentrated into substance
Long-pending 50%, concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract 4
Part, 8 parts of chrysanthemum extract, 3 parts of pseudo-ginseng extract solution, 3 parts of Tween 80,0.05 part of FOS, 6 parts of glycerine, P-hydroxybenzoic acid
0.01 part of sodium, 5.5 parts of tea oil, 600 parts of purified water, each raw material is stirred, 121 DEG C of sterilizing 20min, be cooled to room
Packing can obtain fragrant plant mouthwash after temperature.
The antibacterial experiment in vitro of the fragrant mouthwash of the present invention of embodiment 6
Strain used in this experiment and culture medium are respectively α-hemolytic streptococcus (32209), beta hemolytic streptococcus
(32210), ETEC (44102), proteus vulgaris (49101), Salmonella paratyphi A (50001), dysentery
Disease Shigella (51252), staphylococcus aureus [26111 (5)], Bacillus influenzae (58529-4), nutrient agar
(Nat'l Pharmaceutical ＆ Biological Products Control Institute)；Opacity tube (Chinese bacterial turbidity standard, Chinese medicine biology combinations examine and determine institute).
Antibacterial experiment in vitro：1. prepare drug containing agar plate.Tested material is prepared into different pharmaceutical concentration by doubling dilution
Culture medium, heating, each required pH value is modulated, 121 DEG C of 30 min of sterilizing, is cooled to 45 DEG C.Pour into aseptic flat board (plate d=65
Mm, 10 ml/ plates), the extension rate for finally making stoste containing tested material in culture medium (2g/ml) is respectively l：2,1：4……1：
1024.Do respective blank control culture medium simultaneously.2. it is inoculated with.The young age bacterium for reaching the third generation is taken, respectively with 0.9% sodium chloride
Solution is inoculated in each self-contained of different doubling dilutions respectively by the bacterium solution to be checked that standard opacity tube corrected concentrations are 108 cfu/ml
Medicine agar surface, while 3 points of parallel point is inoculated with, make contain 2 one bacterium solutions at every.The liquid-drop diameter of each vaccination is 5-8 mm.Treat
After vaccination is dried, upset flat board is in the 36 DEG C of h of constant incubator culture 20 observation results (while doing blank control).3. judge
Standard.Using the minimum dilution tested material concentration on the agar plate for occurring without bacterium colony as its minimum inhibitory concentration (MIC).
Mouthwash in this experiment prepared by fragrant mouthwash selection example 3 is as Experimental agents, and it is to each pathogenic bacteria
The minimal inhibitory concentration of strain is as shown in table 1：
| Bacterial strain | Minimal inhibitory concentration（MIC, g/ml） | Drug dilution degree |
| α-hemolytic streptococcus | 0.008 | 1：256 |
| Beta hemolytic streptococcus | 0.016 | 1：128 |
| EHEC | 0.032 | 1：64 |
| Proteus vulgaris | 0.016 | 1：128 |
| Salmonella paratyphi A | 0.032 | 1：64 |
| Shigella dysenteriae | 0.064 | 1：32 |
| Bacillus influenzae | 0.016 | 1：128 |
| Staphylococcus aureus | 0.032 | 1：64 |
As a result show, the fragrant mouthwash of the present invention is respectively provided with good fungistatic effect to most pathogenic bacteria, this for by
For the external world infects triggered oral inflammation patient, there is highly important therapeutic potential.
Claims (7)
1. a kind of preparation method of fragrant plant mouthwash, it specifically includes following step：
1）It is prepared by aromatic plant extract：Peppermint, honeysuckle and thyme are respectively crushed into powder, according to Herba Menthae powder, honeysuckle
Powder is 1 with thyme powder mass ratio:0.8-1.6:4-8 ratio is mixed to prepare aromatic plant powder, and it is added to aromatic plant powder
The purified water of 5 times of volumes of quality, is placed in Microwave Extraction device, and it is 350W-500W to control Microwave Extraction power, continuous extraction
Extract solution is transferred in boiler after 15-25min, computer heating control distillation kettle temperature is 55-69 DEG C, and distillation pot inner pressure is
2-3Kpa, continuous still 1-1.5h, temperature is increased to 150-160 DEG C, distillates fragrant plant oil-water mixture, by fragrant plant
Oil-water mixture is by condensing tube condensation, and the inlet temperature of condenser pipe is 150 DEG C, and outlet temperature is 70 DEG C, is then passed through
Oil water separator is separated, and obtains including the aromatic plant extract of essential oil；
2）Chrysanthemum extracts active ingredients：It will be cleaned after chrysanthemum stalk and cross 20 mesh sieves after being ground into chrysanthemum powder after drying, by chrysanthemum powder
Extraction solution is prepared by mixing into the ethanol of entrainer 95%；Extraction solution is placed in extraction kettle, super face is inputted into extraction kettle
Boundary's CO 2 fluid, it is 24-28MPa to set extraction kettle pressure, and temperature is 35-55 DEG C, extraction time 2-4h；Dissolved with extraction
The supercritical carbon dioxide fluid for going out thing successively enters separating still I and separating still II through pressure-reducing valve, and it is 6- to set the pressure of separating still I
8MPa, temperature are 44-48 DEG C, collect extract I；It is 4-5MPa to set the pressure of separating still II, and temperature is 32-34 DEG C, collects extraction
Take liquid II；Combining extraction liquid I and extract II obtain chrysanthemum extract；
3）The preparation of Notogineng Extract：After chrysanthemum is cleaned, 40-60 DEG C of vacuum drying 12-24 hour, crush, cross 60-80 mesh sieves,
Chrysanthemum powder adds distilled water and carries out refluxing extraction after sieving, and extraction conditions are that solid-liquid ratio is 1：10-1：20, Extracting temperature is
80-95 DEG C, extraction time is 60-90 minutes；Filtering, 15-20 minutes are centrifuged by filtrate under the conditions of 10000-12100g；Then
Filtered again using filter paper, filtrate is concentrated into the 40-50% of original volume, and concentration filtrate is pseudo-ginseng extract solution；
4）It is prepared by fragrant plant mouthwash：Fragrant plant mouthwash is prepared according to following ratio of weight and number：Aromatic plant extract
4-5 parts, chrysanthemum extract 6-8 parts, pseudo-ginseng extract solution 3-5 parts, 2 parts -3 parts of Tween 80,0.05 part -2 parts of FOS, glycerine 4
Part -6 parts, P-hydroxybenzoic acid sodium 0.01-0.2 parts, tea oil 3.5-5.5 parts, purified water 600-800 parts are abundant by each raw material
Stir, 121 DEG C of sterilizing 20min, be cooled to packing after room temperature and can obtain fragrant plant mouthwash.
2. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that the step 1）Middle fragrance
Herba Menthae powder, honeysuckle powder and thyme powder mass ratio are 1 in Plant Powder:1.2:6.
3. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that the step 1）Middle microwave
Extraction power is 450W, extraction time 20min.
4. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that the step 1）Middle distillation
Temperature is 62 DEG C, distillation time 1h.
5. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that chrysanthemum in the step 2)
The mass ratio of powder and entrainer is 1：4-6.
6. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that the step 2）Middle extraction
Kettle pressure is 26MPa, and temperature is 45 DEG C, extraction time 3h.
7. the preparation method of fragrant plant mouthwash according to claim 1, it is characterised in that the step 2）Middle setting
The pressure of separating still I is 7MPa, and temperature is 46 DEG C；It is 4.5MPa to set the pressure of separating still II, and temperature is 33 DEG C.
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| CN108653119A (en) * | 2018-08-22 | 2018-10-16 | 大连民族大学 | A kind of herbaceous plant purely-natural liquid shampoo |
| CN108785230A (en) * | 2018-08-06 | 2018-11-13 | 大连民族大学 | More effect facial treatment liquid foundation of edible natural |
| CN111771917A (en) * | 2020-08-06 | 2020-10-16 | 訾孟州 | High-activity thyme plant essential oil compound antibacterial disinfectant and preparation method thereof |
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