CN102397176A - Traditional Chinese herbal gargle liquid and preparation method thereof - Google Patents
Traditional Chinese herbal gargle liquid and preparation method thereof Download PDFInfo
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- CN102397176A CN102397176A CN2010102841840A CN201010284184A CN102397176A CN 102397176 A CN102397176 A CN 102397176A CN 2010102841840 A CN2010102841840 A CN 2010102841840A CN 201010284184 A CN201010284184 A CN 201010284184A CN 102397176 A CN102397176 A CN 102397176A
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- gargarism
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Abstract
The invention relates to a traditional Chinese herbal gargle liquid and a preparation method thereof, the traditional Chinese herbal gargle liquid is mainly prepared by main raw materials and auxiliary materials in part by weight: 300 swung dash 600g of dandelion, 100 swung dash 300g of elsholtzia, 2 swung dash 80g of thickening agent, 2 swung dash 20g of flavoring agent, 5 swung dash 120g of solubilizing agent, 2 swung dash 6g of preservative and 2000g of water; and the preparation method is that: the elsholtzia is extracted with volatile oil, the residues of the elsholtzia are mixed with the dandelion to decoct in the water, the mixture is filtered and concentrated, is added with the volatile oil and the auxiliary materials, is stirred to dissolve, is added with enough water, is uniformly mixed and is filtered, so the product can be obtained after being packed. The gargle liquid has the obvious antibiotic and antiphlogistic functions, does not have irritant and residual peculiar taste in the oral cavity after being used, can be used as the medicine for curing oral diseases, and also is applicable to being used as an oral cavity cleanness health product.
Description
Technical field
The invention belongs to the oral care product field, being specifically related to a kind of is the Chinese medicine gargarism and the method for making thereof of primary raw material with Herba Taraxaci and Herba Moslae.
Background technology
Gargarism is a kind of convenience, effective oral care product; Can remove food debris in the oral cavity, reduce or suppress the growth and breeding of antibacterial in the oral cavity, fresh breath; Anti-inflammation detumescence; Keep the oral hygiene cleaning, diseases such as gingivitis, periodontitis, oral ulcer are played prevention and auxiliary treatment effect, in oral cavity health and treatment field extensive use.
According to purpose classification, gargarism can be divided into therapeutic type and health two big classes.The therapeutic type gargarism comprises and contains two kinds in chemical medicine and Chinese medicine; The chemical medicated bag that is usually used in gargarism is drawn together chlorhexidine, Borax, hibitane, cetylpyridinium chloride, nitrofural, metronidazole and tinidazole etc.; These chemical medicine have significant antibacterial and anti-inflammation functions, are mainly used in the treatment of oral disease, but mouthfeel is poor, side reaction is many, be prone to produce drug resistance; Particularly be prone to cause oral cavity and bottleneck throat dysbacteriosis, unsuitable life-time service.In order to overcome the shortcoming of chemical medicine; People have researched and developed the plurality of Chinese gargarism; Like the clean gargarism of mouth, Folium Crossostephii Chinensis gargarism, compound Radix Scutellariae gargarism, the clean silver-colored gargarism of golden Cape jasmine, tasty and refreshing clear gargarism, compound Radix zanthoxyli gargarism etc.; These Chinese medicine gargarism all contain pure medicinal Chinese crude drug, only are suitable as medicine and use, and are not suitable for healthy population and are used for oral cavity health.All can be in the oral cavity after chemical medicine or Chinese medicine gargarism use residual corresponding drug flavor, influence the short-term sense of taste, the compliance of reduction medicine for treatment is particularly to the child.The health gargarism all belongs to sterile products class (font size disappears) in the market; Like the refreshing gargarism of crystalline substance, clean beautiful refined gargarism, Fa Hemu collutory, Li Shidelin collutory etc.; According to the Ministry of Public Health relevant regulations; The font size that the disappears product of gargling is only applicable to oral disinfecting, does not possess any therapeutic effect, can not be used for the treatment of oral disease.
Ministry of Public Health has been announced 83 kinds of integration of edible and medicinal herbs article successively, not only can be used as food but also can be used as drug use.We have carried out the literature survey arrangement of modern and traditional medicine to these integration of edible and medicinal herbs article; Discover that Herba Taraxaci and Herba Moslae have conclusive significant anti-inflammation drug effect; And all be used to treat oral disease and oral cavity health, determined curative effect in clinical in modern times and the folk remedy.
Herba Taraxaci has another name called Herba crotalariae albidae, grandmother's fourth, is the important traditional Chinese herbal medicine of China, and its source is feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz. and alkali ground Herba Taraxaci Taraxacumborealisinense Kitam. or the dry herb that belongs to several plants together; Nature and flavor are bitter, sweet, cold, return liver stomach warp, and function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Be used for furuncle swelling toxin, acute mastitis, scrofula; Conjunctival congestion, pharyngalgia, lung abscess; Acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria [" Chinese pharmacopoeia 2010 version one one the 331st page].Modern medicine and pharmacology research confirms; Herba Taraxaci contains taraxasterol, choline, inulin, pectin and various trace elements and vitamin, and its bacteriostasis is very strong, and gastric mucosa is had protective effect; Also have antiendotoxin, antiviral and anti-inflammatory activity; The clinical treatment that can be used for multiple infectious disease comprises being used to treat oral ulcer and periodontitis all has good result [" modern Chinese medicine " 2010 the 4th phases, the 18th to 20 page].
Herba Moslae is the dry aerial parts of labiate Mosla chinensis Maxim. Mosla chinensis Maxim. or Mosla chinensis Maxim.cv.Jiangxiangru Mosla chinensis ' Jiangxiangru ', and nature and flavor are hot, tepor, attach to the lung and stomach meridians; Function relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach; Be used for summer-heat damp cold, fever with aversion to cold, it is lossless to have a headache; Stomachache is vomited and diarrhoea, dysuria [" Chinese pharmacopoeia 2010 version one one the 242nd to 243 page].The main active of Herba Moslae is volatile oil, flavone and various trace elements; Herba Moslae has good bacteriostasis to staphylococcus aureus, escherichia coli, streptococcus, pasteurellosis bacillus, has pharmacological actions such as broad-spectrum antibacterial antiviral, anti inflammation and heat resolution, enhance immunity [" Yunnan Chinese medicine journal was rolled up the 48th to 50 page of the 8th phase in 2008 29].Herba Moslae liquid is used for oral ulcer, root canal disinfection, dental pulp and bacterial plaque treatment and all obtains satisfactory effect [" Chinese medicine Leader, Hunan " 2003 9 the 7th phase of volume the 32nd to 33 page] clinical.Because Herba Taraxaci and Herba Moslae two flavor medical materials are medicinal and edible plant; Nature and flavor are gentle; Not only edible but also definite anti-inflammation curative effect is arranged, safety is good, keeps healthy and treats two suitable; Be particularly suitable for all kinds of crowds and comprise that child, old people, anemia of pregnant woman, patient etc. are used for oral cavity health, and prevention and treatment oral disease.
Summary of the invention
The purpose of this invention is to provide a kind of is the Chinese medicine gargarism that primary raw material is processed with Herba Taraxaci and Herba Moslae; This two flavors primary raw material prescription has significant antibacterial and anti-inflammation functions; And all be again the medicinal and edible plant that Ministry of Public Health is announced; Safety non-toxic is processed gargarism and both can be used as medicine and be used for the patient treatment oral disease, also is fit to all kinds of healthy populations as the oral cavity cleaning health product.
Antibacterial The pharmacological results confirms that the present invention has strengthened fungistatic effect than Herba Taraxaci or Herba Moslae single medical material after Herba Taraxaci and Herba Moslae are filled a prescription.The gargarism nonirritant that the present invention processes, noresidue abnormal flavour, integration of edible and medicinal herbs materials safety property is good, is fit to oral cavity health and treatment life-time service.
The objective of the invention is to be achieved through following technical scheme: it is formulated that primary raw material and adjuvant are pressed the row weight portion:
Herba Taraxaci (medical material) 300～600g
Herba Moslae (medical material) 100～300g
Thickening agent 2～80g
Correctives 2～20g
Solubilizing agent 5～120g
Antiseptic 2～6g
Water adds to 2000g
Described thickening agent is pectin, arabic gum, glycerol, methylcellulose, hypromellose, sodium alginate; Correctives is glucide, steviosin, aspartame, glycyrrhizin, edible essence; Solubilizing agent is sodium lauryl sulphate, tween, ethanol, and antiseptic is potassium sorbate, sodium benzoate, nipalgin.
The concrete method for making of Chinese medicine gargarism of the present invention is following: Herba Moslae is extracted volatile oil, and is subsequent use.Herba Moslae residue and Herba Taraxaci merge decocting and extract 2 times, and merge extractive liquid, filters, and suitably concentrate; Add Herba Moslae volatile oil, thickening agent, correctives and antiseptic with the solubilizing agent mixing successively, fully stirring and dissolving adds water to capacity; Mix homogeneously leaves standstill 24 hours after-filtration, divides packing.
The Chinese medicine gargarism mouthfeel delicate fragrance that the present invention makes does not have drug smell, and each rinsing the mouth time is 2～3 minutes when normally using, and everyone 2～3 times, oral mucosa and throat there are not any zest, the residual abnormal flavour sense in no oral cavity does not influence the sense of taste.Because primary raw material of the present invention is a food plant, even the rinsing the mouth time substantially exceeds normal service time, perhaps child, old man and the unfavorable person of other oropharynxs can not produce any GI irritation property or other potential safety hazard because of the careless and wrong gargarism of swallowing yet.
The specific embodiment
Embodiment 1
Prescription: Herba Taraxaci (medical material) 500g
Herba Moslae (medical material) 300g
Pectin 2g
Glucide 2g
Herba Menthae essence 2g
Tween 80 6g
Potassium sorbate 2g
Water adds to 2000g
Take by weighing the Herba Moslae medical material, the water vapor method extracts volatile oil, and is subsequent use.Extract back residue and Herba Taraxaci merging, add 6 times and 3 times of water extraction respectively 2 times, merge extractive liquid; Filter, when being concentrated into 1500g, add Herba Moslae volatile oil with the Tween 80 mix homogeneously; Mix homogeneously (take a sample subsequent use this moment) adds pectin, glucide, potassium sorbate and essence more successively, adds water to capacity; Fully the stirring and dissolving mixing leaves standstill 24 hours after-filtration, divides packing.
Embodiment 2
Prescription: Herba Taraxaci (medical material) 400g
Herba Moslae (medical material) 200g
Glycerol 80g
Aspartame 1.2g
Strawberry essence 2g
Sodium lauryl sulphate 2g
Ethanol 100g
Sodium benzoate 5g
Water adds to 2000g
Take by weighing the Herba Moslae medical material, the water vapor method extracts volatile oil, and is subsequent use.Extract back residue and the merging of Herba Taraxaci medical material, add 6 times of water and 4 times of water extraction 2 times respectively, merge extractive liquid; Filter, when being concentrated into 1500g, add Herba Moslae volatile oil with the sodium lauryl sulphate mix homogeneously; Mix homogeneously (take a sample subsequent use this moment) adds glycerol, ethanol, aspartame, sodium benzoate and essence more successively, adds water to capacity; Fully the stirring and dissolving mixing leaves standstill 24 hours after-filtration, divides packing.
Comparative example 1
Prescription: Herba Taraxaci (medical material) 500g
Tween 80 6g
Water adds to 1500g
Take by weighing the Herba Taraxaci medical material, add 6 times and 3 times of water extraction respectively 2 times, merge extractive liquid, filters, and when being concentrated into 1500g, adds Tween 80, mix homogeneously, and it is subsequent use to take a sample.
Comparative example 2
Prescription: Herba Moslae (medical material) 300g
Tween 80 6g
Water adds to 1500g
Take by weighing the Herba Moslae medical material, the water vapor method extracts volatile oil, and is subsequent use, residue add respectively 6 times with 3 times of water extraction 2 times, merging filtrate filters, and when being concentrated into 1500g, adds and the blended Herba Moslae volatile oil of Tween 80, stirs, it is subsequent use to take a sample.
Comparative example 3
Adopt disk diffusion method, carry out the extracorporeal bacteria inhibitor test of embodiment 1, embodiment 2, comparative example 1 and comparative example 2 samples, relatively their bacteriostasis intensity.With activation and to process escherichia coli and the staphylococcus aureus bacteria suspension separate application of suitable concentration dull and stereotyped in agar culture medium; The circle sterilization filter paper of cut-off footpath 5mm lies against on the culture medium flat plate, quantitatively drips each sample respectively, does contrast with normal saline; Cultivated 24 hours for 37 ℃; Measure antibacterial circle diameter, repeat 3 times calculating mean value, the result sees table 1.
Embodiment 1 and embodiment 2 compare with normal saline, and both have significant inhibitory effect to escherichia coli and staphylococcus aureus, explain that gargarism of the present invention has good antibacterial effect.
Embodiment 1 compares with comparative example 1, and the former is obviously higher to the inhibition strength of escherichia coli and staphylococcus aureus, explains that the bacteriostasis of Herba Taraxaci and Herba Moslae combination obviously is superior to the Herba Taraxaci folk prescription.
Embodiment 1 compares with comparative example 2, and the former also is obviously higher to the inhibition strength of escherichia coli and staphylococcus aureus, explains that the bacteriostasis of Herba Taraxaci and Herba Moslae combination obviously is superior to the Herba Moslae folk prescription.
Each embodiment of table 1 and comparative sample bacteriostatic test result
Claims (4)
1. a Chinese medicine gargarism is characterized in that it is a primary raw material with Herba Taraxaci and Herba Moslae, and it is formulated to extract back and adjuvant.
2. gargarism according to claim 1, it is formulated to it is characterized in that primary raw material and adjuvant are pressed the row weight portion:
Herba Taraxaci (medical material) 300～600g
Herba Moslae (medical material) 100～300g
Thickening agent 2～80g
Correctives 2～20g
Solubilizing agent 5～120g
Antiseptic 2～6g
Water adds to 2000g
3. gargarism according to claim 1; It is characterized in that thickening agent is pectin, arabic gum, glycerol, methylcellulose, hypromellose, sodium alginate; Correctives is glucide, steviosin, aspartame, glycyrrhizin, edible essence; Solubilizing agent is sodium lauryl sulphate, tween, ethanol, and antiseptic is potassium sorbate, sodium benzoate, nipalgin.
4. gargarism according to claim 1 is characterized in that method for preparing is following: Herba Moslae is extracted volatile oil, and residue and Herba Taraxaci merge; Extracting in water 2 times, merge extractive liquid, filters, and suitably concentrates; Herba Moslae volatile oil, thickening agent, correctives and the antiseptic of adding and solubilizing agent mixing, fully stirring and dissolving adds water to the capacity mixing; Leave standstill 24 hours after-filtration, divide packing.
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| CN2010102841840A CN102397176A (en) | 2010-09-17 | 2010-09-17 | Traditional Chinese herbal gargle liquid and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550454A (en) * | 2013-11-10 | 2014-02-05 | 孙丽美 | Traditional Chinese medicine preparation for treating periodontitis |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
| CN107550808A (en) * | 2017-08-29 | 2018-01-09 | 皖南医学院 | A kind of moisturizing baby's hip pad emulsion of diaper rash of dispelling and preparation method thereof |
| CN107648136A (en) * | 2017-09-28 | 2018-02-02 | 杨功平 | Nurse the mouthwash in oral cavity and preparation method thereof |
| CN109106811A (en) * | 2018-11-01 | 2019-01-01 | 山东省科学院生物研究所 | A kind of liquid composition of antalgic and inflammation relieving and the preparation method and application thereof |
| CN110025517A (en) * | 2019-04-10 | 2019-07-19 | 伊春五加参药业有限责任公司 | It is a kind of for treating the mouthwash of mouth disease |
| CN110151574A (en) * | 2019-07-08 | 2019-08-23 | 河北科技大学 | A kind of stability chlorine dioxide gargle and preparation method thereof |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN114983874A (en) * | 2022-06-10 | 2022-09-02 | 浙江工业大学 | Traditional Chinese medicine volatile oil composition mouthwash |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744985A (en) * | 2010-02-26 | 2010-06-23 | 王忠民 | Medicament for treating child repetitive respiratory infection and low immunity |
-
2010
- 2010-09-17 CN CN2010102841840A patent/CN102397176A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744985A (en) * | 2010-02-26 | 2010-06-23 | 王忠民 | Medicament for treating child repetitive respiratory infection and low immunity |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550454A (en) * | 2013-11-10 | 2014-02-05 | 孙丽美 | Traditional Chinese medicine preparation for treating periodontitis |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
| CN107550808A (en) * | 2017-08-29 | 2018-01-09 | 皖南医学院 | A kind of moisturizing baby's hip pad emulsion of diaper rash of dispelling and preparation method thereof |
| CN107648136A (en) * | 2017-09-28 | 2018-02-02 | 杨功平 | Nurse the mouthwash in oral cavity and preparation method thereof |
| CN109106811A (en) * | 2018-11-01 | 2019-01-01 | 山东省科学院生物研究所 | A kind of liquid composition of antalgic and inflammation relieving and the preparation method and application thereof |
| CN110025517A (en) * | 2019-04-10 | 2019-07-19 | 伊春五加参药业有限责任公司 | It is a kind of for treating the mouthwash of mouth disease |
| CN110151574A (en) * | 2019-07-08 | 2019-08-23 | 河北科技大学 | A kind of stability chlorine dioxide gargle and preparation method thereof |
| CN110151574B (en) * | 2019-07-08 | 2021-09-28 | 河北科技大学 | Stable chlorine dioxide gargle and preparation method thereof |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN114983874A (en) * | 2022-06-10 | 2022-09-02 | 浙江工业大学 | Traditional Chinese medicine volatile oil composition mouthwash |
| CN114983874B (en) * | 2022-06-10 | 2024-02-23 | 浙江工业大学 | A mouthwash containing Chinese medicinal volatile oil composition |
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Application publication date: 20120404 |