CN110025517A

CN110025517A - It is a kind of for treating the mouthwash of mouth disease

Info

Publication number: CN110025517A
Application number: CN201910275449.1A
Authority: CN
Inventors: 林春和; 黎世柱
Original assignee: Yichun Wujiasen Pharmaceutical Co Ltd
Current assignee: Yichun Wujiasen Pharmaceutical Co Ltd
Priority date: 2019-04-10
Filing date: 2019-04-10
Publication date: 2019-07-19

Abstract

The invention discloses a kind of for treating the mouthwash of mouth disease, is prepared by Radix Berberidis extract, dandelion extract, asiatic moonseed extract, Baical Skullcap root P.E, solvent, cosolvent and auxiliary agent.The present invention selects the main actives of the raw materials as mouthwash such as barberry, dandelion, rhizoma menispermi and radix scutellariae, all have clearing heat and detoxicating, antiphlogistic antibacterial effect, and main active is Chinese medical extract, safely and effectively, it can be used for a long time, can be used for treating the acute and chronic diseases as caused by bacterium and inflammation such as canker sore, swelling and aching of gum, pharmacological research is shown, mouthwash of the invention has the function of bactericidal antiphlogistic, swelling and pain relieving, materials safety, without obvious adverse reaction after use.

Description

It is a kind of for treating the mouthwash of mouth disease

Technical field

The present invention relates to a kind of for treating the mouthwash of mouth disease, belongs to field of medicaments.

Background technique

Mouthwash is also known as oral washing liquid, is dental health product, has the function of killing except microorganism tartar, and prevent The effect of saprodontia, gingivitis and halitosis for being induced by it.Main component is essence, surfactant, fluoride, strontium chloride, wine Essence and water etc. are a kind of daily products for oral hygiene easy to carry, increasingly have been favored by people.

Canker sore is also known as recurrent aphthous ulcer, is the highest a kind of disease of disease incidence in oral keritonocytes, betides mouth The ulcerative damages illness illness of chamber mucous membrane mostly occurs in the positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, Sharp ache when it breaks out, local cusalgia is obvious, and serious person also will affect diet, speak, and seriously affects daily work, study And life, oral ulcer hair is caused by multifactor comprising malnutrition, hypovitaminosis, common cold, digestion are not Good, nervous, gloomy not happy etc., for age of onset generally between 10~30 years old, women is more, can fall ill throughout the year, Recurrent ulcer has self limiting, can be in self-healing in 10 days or so.

Tradition includes using heat-clearing and fire-reducing drug and smearing anti-inflammatory medicinal powder to the treatment method of canker sore, wherein using clear Heat drop fire curative effect of medication is slow, the treatment cycle time is long, and cure rate is lower, there is a small amount of cyclic recurrence phenomenon；And it uses and applies Effacement inflammation medicinal powder directly smears anti-inflammatory to oral cavity affected part, can play quick therapeutic effect, but smear application method not in oral cavity It is convenient, and medicinal powder bitter taste is heavier, and the short-term recurrence rate of canker sore is higher.

Summary of the invention

In view of this, the present invention provides a kind of for treating the mouthwash of mouth disease, treatment mouth disease joined Active constituent, the effect in existing usual mouthwash cleaning oral cavity, fresh breath, while can reduce the mouth of suffering from oral disease Chamber sense of discomfort promotes the quick healing of mouth disease.

To achieve the goals above, the present invention adopts the following technical scheme:

It is a kind of for treating the mouthwash of mouth disease, be prepared by the raw material of following weight percent: barberry mentions Take object 0.05-0.95%, dandelion extract 0.01-0.5%, asiatic moonseed extract 0.01-0.5%, Baical Skullcap root P.E 0.01- 0.95%, cosolvent 4%-6%, auxiliary agent 2%-4%, surplus are solvent.

The present invention selects the main actives of the raw materials as mouthwash such as barberry, dandelion, rhizoma menispermi and radix scutellariae, Have effects that clearing heat and detoxicating, antiphlogistic antibacterial, and main active is Chinese medical extract, safely and effectively, can be used for a long time, it can For treating the acute and chronic diseases as caused by bacterium and inflammation such as canker sore, swelling and aching of gum, pharmacological research is shown, of the invention Mouthwash has the function of bactericidal antiphlogistic, swelling and pain relieving, materials safety, without obvious adverse reaction after use.

Radix Berberidis extract is that Berberidaceae plant pierces the root skin of black pearl, berberis brachypoda Maxim, black stone pearl etc. or the extract of stem skin, The effect of it is with heat-clearing, dampness removing, dissipates the stasis of blood, can be used for curing mainly dysentery with bloody stool, jaundice, pharyngalgia, hot eyes, the illnesss such as traumatic injury.

Dandelion herb is containing taraxasterol, choline, synanthrin, pectin etc., and dandelion extract is for treating liver and gallbladder Capsule obstruction, improves liver function, promotes bile secretion and uses as diuretics.

The dry rhizome that asiatic moonseed extract is menispermaceae plant menispermum dauricum Menis permum dauricum DC. is through adding Extract made of work, for treating abscess of throat, enteritis and dysentery, rheumatic arthralgia.

Baical Skullcap root P.E be the extracted drying of radix scutellariae made from flaxen powder, heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, Miscarriage prevention.For damp and hot, hot summer weather chest tightness and emesis, damp and hot feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle swells Sore, threatened abortion.

Further, solvent is deionized water；

Cosolvent is medical ethanol；

Auxiliary agent be moisturizer, sweetener and any two or three of flavouring agent of mixture, wherein moisturizer be glycerol, Propylene glycol or D-sorbite, sweetener are any one or several mixture of xylitol, Aspartame, saccharin sodium, and flavouring agent is Edible essence.

Application method are as follows: when brushing teeth daily morning and evening or oral cleaning need to be carried out, use treatment oral cavity prepared by the present invention It spues after the mouthwash 18-25ml of disease, the 30s that gargles, is not required to be gargled with water again.

Specific embodiment

The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.

Embodiment 1

For treating the mouthwash of mouth disease, 0.1L is prepared: Radix Berberidis extract by the raw material of following weight 0.05g, dandelion extract 0.01g, asiatic moonseed extract 0.01g, Baical Skullcap root P.E 0.01g, medical ethanol 4g, glycerol 1g and Xylitol 1g, surplus are deionized water.

Embodiment 2

For treating the mouthwash of mouth disease, 0.1L is prepared: Radix Berberidis extract by the raw material of following weight 0.95g, dandelion extract 0.5g, asiatic moonseed extract 0.5g, Baical Skullcap root P.E 0.095g, medical ethanol 6g, propylene glycol 2g With Aspartame 2g, surplus is deionized water.

Embodiment 3

For treating the mouthwash of mouth disease, 0.1L is prepared: Radix Berberidis extract by the raw material of following weight 0.5g, dandelion extract 0.3g, asiatic moonseed extract 0.3g, Baical Skullcap root P.E 0.5g, medical ethanol 5g, glycerol 1g, xylose Alcohol 1g and edible essence 10g, surplus are deionized water.

Embodiment 4

For treating the mouthwash of mouth disease, 0.1L is prepared: Radix Berberidis extract by the raw material of following weight 0.4g, dandelion extract 0.2g, asiatic moonseed extract 0.2g, Baical Skullcap root P.E 0.4g, medical ethanol 5g, D-sorbite 1g, Saccharin sodium 1g and edible essence 1g, surplus are deionized water.

Embodiment 5

For treating the mouthwash of mouth disease, 0.1L is prepared: Radix Berberidis extract by the raw material of following weight 0.6g, dandelion extract 0.4g, asiatic moonseed extract 0.4g, Baical Skullcap root P.E 0.6g, medical ethanol 5g, D-sorbite 1g, Aspartame 1g and edible essence 1g, surplus are deionized water.

Performance detection

1, physical and chemical standards and sanitary standard detection

Respectively for treating the mouthwash of mouth disease prepared by Example 1-5, by the item in QB/T2945-2008 Mesh and method are detected, institute's detection project and result such as table 1.

1 embodiment 1-5 mouthwash performance detection project of table and result

2, zoopery

Healthy, adult experimental rabbit and cavy each 25 are taken, 5 groups is divided by weight, every group of every kind of animal each 5, moves Object test before adaptability raise 7d, 23-25 DEG C of raising temperature, humidity 42%-45%, zoopery to two kinds of animals respectively into Row Skin Irritation Test (an intact skin irritant test method) and Skin allergy test (provide in " disinfection technology standard " Method), every group of animal is used prepared by embodiment 1-5 respectively for treating the mouthwash of mouth disease.

Experimental result shows that the tested skin of each group experimental rabbit is showed no abnormal response, and stimulate the reaction integral is 0, to experiment Rabbit skin is nonirritant, and the tested skin of each group cavy is showed no erythematous response and oedema reaction, and dermoreaction integral is 0, sensitization Rate is 0%, has no skin allergic reaction.

Claims

1. a kind of for treating the mouthwash of mouth disease, which is characterized in that be prepared by the raw material of following weight percent: Radix Berberidis extract 0.05-0.95%, dandelion extract 0.01-0.5%, asiatic moonseed extract 0.01-0.5%, radix scutellariae mention Object 0.01-0.95%, cosolvent 4%-6%, auxiliary agent 2%-4% are taken, surplus is solvent.

2. according to claim 1 a kind of for treating the mouthwash of mouth disease, which is characterized in that the solvent is to go Ionized water.

3. according to claim 1 a kind of for treating the mouthwash of mouth disease, which is characterized in that the cosolvent is Medical ethanol.

4. according to claim 1 a kind of for treating the mouthwash of mouth disease, which is characterized in that the auxiliary agent is to protect Humectant, sweetener and any two or three of flavouring agent of mixture.

5. according to claim 4 a kind of for treating the mouthwash of mouth disease, which is characterized in that the moisturizer is Glycerol, propylene glycol or D-sorbite.

6. according to claim 4 a kind of for treating the mouthwash of mouth disease, which is characterized in that the sweetener is Any one or several mixture of xylitol, Aspartame, saccharin sodium.

7. according to claim 4 a kind of for treating the mouthwash of mouth disease, which is characterized in that the flavouring agent is Edible essence.