CN108420781A - A kind of toothpaste - Google Patents
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- CN108420781A CN108420781A CN201810374996.0A CN201810374996A CN108420781A CN 108420781 A CN108420781 A CN 108420781A CN 201810374996 A CN201810374996 A CN 201810374996A CN 108420781 A CN108420781 A CN 108420781A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention provides a kind of toothpaste, and the toothpaste includes following Chinese medicine composition as bioactive ingredients：1 10 parts by weight propolis total flavones, 10 30 parts by weight Honegsukle flower P.Es, 20 40 parts by weight forsythia suspense extractions, 5 10 parts by weight menthols and 15 30 parts by weight borneols；The Chinese medicine composition is added in toothpaste matrix, and the 5%~15% of the additive amount toothpaste matrix amount described by weight.The effect of present invention is with significantly reducing bacterial number in oral cavity, while also having both pre- preventing parodontitis, gingivitis, halitosis, saprodontia, canker sore.
Description
Technical field
The invention belongs to oral care techniques fields, and in particular to a kind of toothpaste.
Background technology
With the continuous development of society, people enter the fast pace epoch, and living habit, dietary structure occur very therewith
Big variation causes irregular and operating pressure increase of living.If things go on like this, body will accumulate " endogenous toxic material ", cause yin-Yang
It is unbalance, cause to get angry, the oral problems such as dry and astringent throat, gum swelling, canker sore often occur, also will appear that moisture is overweight, liver
The systemic problems such as fiery rising, cause that the tired weight of body is weak, joint motion is unfavorable, poor appetite, insomnia and dreamful sleep, blurring of vision, just
It is secret etc..Encounter excessive internal heat or it is damp and hot it is general take heat-clearing and diuresis-promoting drug or herbal tea is improved, but these are for fast pace life
It is not very convenient to be used for people, is sometimes easy to forget.
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions lack keratinization layer or angling compared with
Difference.Tongue ulcer refer to betide tongue, tongue abdomen position canker sore.Sharp ache when canker sore is broken out, local cusalgia are bright
Aobvious, severe patient can also influence diet, speak, and very big inconvenience is caused to daily life；Can concurrent halitosis, chronic pharyngitis, constipation,
The constitutional symptoms such as headache, dizzy, nauseous, weak, irritated, fever, enlargement of lymph nodes.
Canker sore is the result of many factors comprehensive function comprising local trauma, stress, food,
Drug, malnutrition, hormonal readiness change and vitamin or microelement deficiencies.Systemic disease, heredity, immune and micro- life
Object may play an important role in the generation, development of canker sore.Such as lack trace element zinc, iron, lacks folic acid, vitamin
B12 and malnutrition etc. can reduce immune function, increase the possibility of canker sore morbidity；Streptococcus sanguis and helicobacter pylorus
The bacteriums such as bacterium are also in close relations with canker sore.Canker sore usually implies that body may have potential systemic disease, mouth
Chamber ulcer and gastric ulcer, duodenal ulcer, ulcerative colitis, regional enteritis, hepatitis, female menstrual period, vitamin B complex
Malabsorption disease, vegetative nerve functional disturbance disease etc. are related.
The necessary product that oral care product is people's daily cleaning oral cavity, protects the health of one's mouth, Chinese medicine health-care is implanted into
Into oral care product, a kind of easily health care mode, one-stop solution cleaning oral cavity and health care are provided for fast pace life
Nursing problem.Such as Yunnan Baiyao, Radix zanthoxyli, Chloranthus glaber, pseudo-ginseng Chinese medicinal toothpaste play important work to protecting the health of one's mouth
With being favored by consumer very much.But big oral cavity, big health-image are formed in oral care product there are no complete, also office
It is limited to the health care in oral cavity, therefore, how breaks through single-minded oral care limitation, so that healthcare function is extended to Whole Body, be
Fast pace life provider is that one of ordinary skill in the art are badly in need of the technical barrier solved.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of toothpaste, and the toothpaste includes following Chinese medicine composition as life
Object active constituent：1-10 parts by weight propolis total flavones, 10-30 parts by weight Honegsukle flower P.E, the extraction of 20-40 parts by weight Fructus Forsythiaes
Object, 5-10 parts by weight menthol and 15-30 parts by weight borneols；The Chinese medicine composition is added in toothpaste matrix, additive amount
The 5%~15% of the toothpaste matrix amount described by weight.
In one embodiment, the Chinese medicine composition includes following component：3-6 parts by weight propolis total flavones, 20-
25 parts by weight Honegsukle flower P.Es, 30-40 parts by weight forsythia suspense extraction, 5-10 parts by weight menthol and 15-20 parts by weight ice
Piece.
In one embodiment, the toothpaste further includes 65%~85% abrasive, 3%~5% surface by weight
Activating agent, 10%~30% moisturizer, 0.1%~0.3% sweetener and 0.1%~0.3% preservative.
In one embodiment, the abrasive is selected from calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate, silica, hydrogen
One kind in aluminium oxide or combinations thereof.
In one embodiment, the surfactant is selected from sodium lauryl sulfate, 2- acyloxy keys sodium sulfonate, the moon
One kind or combinations thereof in osmanthus acylsarcosine sodium, sldium lauryl sulfate, cocoyl glycine betaine.
In one embodiment, the one kind of the moisturizer in glycerine, sorbierite, propylene glycol and polyethylene glycol
Or combinations thereof.
In one embodiment, the preservative in sodium benzoate, sodium dehydroacetate and parabens one
Kind or combinations thereof.
In one embodiment, one kind in glycerine, cyclohexylamine sulfonic acid sodium and saccharin sodium of the sweetener or its
Combination.
General flavone highest content is 17.2%, minimum 8.2% in propolis, average out to 12.2%.Flavonoid substances are by conduct
The core index of propolis, the height of Flavonoids in Propolis class content are a basic foundations of current evaluation propolis quality.In propolis
Flavones content refer to flavonoid species number, the height of not a certain Flavonoid substances content and low (such as some states
Family's import propolis requires the sum of the content of Quercetin, chrysin, Galangin and squirrel element that should reach the 50% of general flavone content).
Flavones content in nature in such as hay certain plants is significantly larger than propolis, but its health value can not compare with propolis
It is quasi-, because the general flavone in propolis is made of more than 30 kinds of Flavonoid substances.The key of propolis does not lie in the height of flavones
It is low, and be its excellent Natural Proportioning, many kinds of substance and play more diseases with the purpose controlled.
Honegsukle flower P.E is a kind of extract, extracts from honeysuckle flower, and main ingredient is chlorogenic acid, color
It is brown ceramic powder, can be used as the raw material of drug, health products, cosmetics.Its action and efficacy is embodied in anti-inflammatory, two aspect of antibacterial.It is green
Ortho acid clinically has the function of antibacterial anti-inflammatory；Modern medicine study proves that honeysuckle is for streptococcus, staphylococcus, wound
Cold bacillus, shigella dysenteriae, large intestine and Pseudomonas aeruginosa, Diplococcus pneumopniae, Bordetella pertussis, meningococcus etc., have stronger
Antibacterial power has certain curative effect to treatment influenza and inflammation.
Forsythia suspense extraction active ingredient includes hypericum perforatum herb compound containing benzene and two anthracene ketone：Hypericin, pseudo- gold
Silk peach element, former hypericin, former pseudohypericin, ring pseudohypericin, different hypericin, rheum emodin-grace ketone, Hypericum Chinense are auxiliary
Dehydrogenation dianthrone etc..Forsythia suspense extraction mainly have antibacterial, antiviral, anti-inflammatory, Antiradiation injury, it is antipyretic the effects that, Fructus Forsythiae in addition
To cardiovascular system, to capillary permeability and elastin laminin enzyme activity is inhibited to have a certain impact, is also spat with town,
The effects that anti-liver injury treatment hepatitis, cardiac stimulant, diuresis.The acute anemopyretic cold of common forsythia fruit for treating, carbuncle sore tumefacting virus, lymph junction
The diseases such as core, urinary tract infections.
Menthol in the leaf and stem of peppermint by being extracted, white crystal, molecular formula C10H20O, is peppermint and lavender
Main component in essential oil.It is used as excitants in medicine, external application is used for local analgesia, antipruritic, and headache, dizziness, mosquito stings
It stings；Collunarium is had a stuffy nose for catching cold, and sucking or spraying are used for sphagitis；Taking orally can be with stomach invigorating.
Borneol also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing
Deng through steam distillation and being recrystallized and obtained by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves.It can be used for closing
It demonstrate,proves coma, be used for red eye, swell pain, larynx numbness aphtha is used for sore swell and ache curative, is not held back after bursting.Borneol acrid flavour, hardship, are slightly cold；The thoughts of returning home,
Liver, lung channel；Delicate fragrance a surname dissipate has the effect of inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, removing nebula, cures mainly high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, apoplexy
Coma due to blocking of the respiratory system frightened epilepsy, summer-heat and damp blinds clear key, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, red eye, swell pain, pterygium.
Compared with prior art, the invention has the advantages that：The present invention has bacterium in apparent reduction oral cavity
Quantity, while the effect of also have both pre- preventing parodontitis, gingivitis, halitosis, saprodontia, canker sore.
Specific implementation mode
In order to make art technology field personnel more fully understand the technical solution in the application, below in conjunction with following
The invention will be further described in conjunction with the embodiments, it is clear that and described embodiments are only a part of embodiments of the present application,
Instead of all the embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not making creative labor
The all other embodiment obtained under the premise of dynamic, shall fall within the protection scope of the present application.With reference to embodiment to this
Invention is further described.
The preparation of one formulation of tooth-paste 1 of the present invention of embodiment
1 composition of formula：
Chinese medicine composition：6 parts by weight propolis total flavones, 15 parts by weight Honegsukle flower P.Es, the extraction of 25 parts by weight Fructus Forsythiaes
Object, 10 parts by weight menthols and 25 parts by weight borneols；
Abrasive：200 weight parts of calcium carbonate and 450 parts by weight of silica；
Surfactant：20 parts by weight sodium lauryl sulfates；
Moisturizer：150 parts by weight of glycerin；
Preservative：1 parts by weight sodium；
Sweetener：1 parts by weight cyclohexylamine sulfonic acid sodium.
It is as follows to be formulated 1 toothpaste making process：
1) it is added in the first container and is added after weighing sodium lauryl sulfate, glycerine, sodium benzoate and cyclohexylamine sulfonic acid sodium
Deionized water stirring and dissolving；
2) propolis total flavones, Honegsukle flower P.E, forsythia suspense extraction are stirred with deionized water in second container molten
Solution；
3) calcium carbonate, silica, menthol and borneol are added in meal mixer and are uniformly mixed；
4) raw material in the first container and second container is sucked into Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirred
It mixes, sucks the powder in meal mixer, powder deaerates 20 minutes into complete rear opening homogeneous, homogeneous；
5) vacuum outgas after twenty minutes, then homogeneous deaerate 15 minutes, cream can be gone out after the assay was approved.
The preparation of two formulation of tooth-paste 2 of the present invention of embodiment
2 composition of formula：
Chinese medicine composition：5 parts by weight propolis total flavones, 20 parts by weight Honegsukle flower P.Es, the extraction of 35 parts by weight Fructus Forsythiaes
Object, 8 parts by weight menthols and 20 parts by weight borneols；
Abrasive：150 weight parts of calcium carbonate and 500 parts by weight of silica；
Surfactant：30 parts by weight sldium lauryl sulfates；
Moisturizer：100 parts by weight of propylene glycol；
Preservative：1 parts by weight sodium dehydroacetate；
Sweetener：1 parts by weight hexamethylene saccharin sodium.
It is as follows to be formulated 2 toothpaste making process：
1) it is added in the first container to be added after weighing sldium lauryl sulfate, propylene glycol, sodium dehydroacetate and saccharin sodium and go
Ionized water stirring and dissolving；
2) propolis total flavones, Honegsukle flower P.E, forsythia suspense extraction are stirred with deionized water in second container molten
Solution；
3) calcium carbonate, silica, menthol and borneol are added in meal mixer and are uniformly mixed；
4) raw material in the first container and second container is sucked into Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirred
It mixes, sucks the powder in meal mixer, powder deaerates 15 minutes into complete rear opening homogeneous, homogeneous；
5) after vacuum outgas 30 minutes, then homogeneous deaerates 10 minutes, can go out cream after the assay was approved.
Three animal toxicity test of embodiment
Healthy adult mouse 32, half male and half female, weight 15-25g/ only, are divided into two groups.By the formula 1 of the present invention and match
Side 2 is respectively plus 10 times of water are diluted to suspension, after mouse fasting (can't help water) 15 hours, twice a day gavage, and each 5ml,
After 10 days, mouse has no dead, shows that the toothpaste of the present invention is nontoxic.
Example IV model case
1. journey, man, 39 years old, main suit：Bitter taste more than 1 year.Clinical observation：Bitter taste, halitosis, constipation, red tongue body yellow and greasy fur,
Slippery.It is brushed teeth 6 months using formulation of tooth-paste 1 of the present invention, symptom mitigates, and is continuing with 3 months, and all symptoms disappear, and have no bitter taste
Halitosis.
2. Zhu, female, 42 years old, main suit：Bleeding gums, swelling and aching of gum often send out canker sore more than half a year.Clinical observation：Mouthful
Smelly, bitter taste, oral cavity hot gas sense.Using inventive formulation 2 toothpaste, 3 courses for the treatment of, symptom mitigates, after being continuing with 2 months, all diseases
Shape disappears.Follow-up is without recurrence after 1 year.
The comparative test of the effect of five formulation of tooth-paste of the present invention of embodiment
60 canker sore patients are recruited in hospital, are divided into two experimental groups and a control group, every group of 20 people, experiment
Group one and experimental group two are brushed teeth with the formulation of tooth-paste 1 and 2 of the present invention respectively, control group ordinary toothpaste, one day morning and evening each one
It is secondary, twice a day, brush teeth every time 5 minutes.Continuously clothes are brushed teeth 3 months for experimental group and control group.
Treatment results：After three months, one canker sore of experimental group cures 12, and two canker sore of experimental group cures 18,
And control group cures 2.
Conclusion：The toothpaste of the present invention is to canker sore good effect；And the experiment effect of inventive formulation one relatively experiment two
Effect it is more preferable, cure rate higher；First group of cure rate is 60%, and second group of cure rate is 90%.
It should be understood that the present invention disclosed is not limited only to specific method, scheme and the substance of description, because these
It is alterable.It will also be understood that purpose of the terminology used here just for the sake of the specific embodiment scheme of description, rather than
It is intended to limit the scope of the invention, the scope of the present invention is limited solely by the attached claims.
Those skilled in the art, which will also be appreciated that or be able to confirm that, uses no more than routine experiment, institute herein
Many equivalents of the specific embodiment of the present invention stated.These equivalents are also contained in the attached claims.
Claims (8)
1. a kind of toothpaste, which is characterized in that the toothpaste includes following Chinese medicine composition as bioactive ingredients：1-10 weight
Part propolis total flavones, 10-30 parts by weight Honegsukle flower P.E, 20-40 parts by weight forsythia suspense extraction, 5-10 parts by weight menthol and
15-30 parts by weight borneols；The Chinese medicine composition is added in toothpaste matrix, the additive amount toothpaste matrix described by weight
The 5%~15% of amount.
2. toothpaste according to claim 1, which is characterized in that the Chinese medicine composition includes following component：3-6 parts by weight
Propolis total flavones, 20-25 parts by weight Honegsukle flower P.E, 30-40 parts by weight forsythia suspense extraction, 5-10 parts by weight menthol and
15-20 parts by weight borneols.
3. toothpaste according to claim 1, which is characterized in that the toothpaste further includes 65%~85% friction by weight
Agent, 3%~5% surfactant, 10%~30% moisturizer, 0.1%~0.3% sweetener and 0.1%~0.3% anti-corrosion
Agent.
4. toothpaste according to claim 3, which is characterized in that the abrasive is selected from calcium carbonate, calcium monohydrogen phosphate, pyrophosphoric acid
One kind or combinations thereof in calcium, silica, aluminium hydroxide.
5. toothpaste according to claim 3, which is characterized in that the surfactant is selected from sodium lauryl sulfate, 2- acyls
One kind or combinations thereof in oxygroup key sodium sulfonate, sodium lauroyl sarcosine, sldium lauryl sulfate, cocoyl glycine betaine.
6. toothpaste according to claim 3, which is characterized in that the moisturizer is selected from glycerine, sorbierite, propylene glycol and gathers
One kind in ethylene glycol or combinations thereof.
7. toothpaste according to claim 3, which is characterized in that the preservative be selected from sodium benzoate, sodium dehydroacetate and
One kind in parabens or combinations thereof.
8. toothpaste according to claim 3, which is characterized in that the sweetener is selected from glycerine, cyclohexylamine sulfonic acid sodium and sugar
One kind or combinations thereof in smart sodium.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810374996.0A CN108420781A (en) | 2018-04-24 | 2018-04-24 | A kind of toothpaste |
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| CN201810374996.0A CN108420781A (en) | 2018-04-24 | 2018-04-24 | A kind of toothpaste |
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Cited By (2)
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| CN109172556A (en) * | 2018-10-30 | 2019-01-11 | 何凤姣 | A kind of composition and preparation method thereof for treating canker sore |
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| CN109172556A (en) * | 2018-10-30 | 2019-01-11 | 何凤姣 | A kind of composition and preparation method thereof for treating canker sore |
| CN110200869A (en) * | 2019-06-18 | 2019-09-06 | 汪洪涛 | A kind of anti-flu herbal medicine toothpaste of Radix Isatidis |
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