CN109125144A - A kind of toothpaste and its preparation method for preventing canker sore, inhibiting helicobacter pylori - Google Patents
A kind of toothpaste and its preparation method for preventing canker sore, inhibiting helicobacter pylori Download PDFInfo
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- CN109125144A CN109125144A CN201811295646.1A CN201811295646A CN109125144A CN 109125144 A CN109125144 A CN 109125144A CN 201811295646 A CN201811295646 A CN 201811295646A CN 109125144 A CN109125144 A CN 109125144A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
Prevent canker sore, toothpaste of inhibition helicobacter pylori and preparation method thereof the present invention relates to a kind of, the toothpaste includes the raw material of following parts by weight: 1~3 part of Boswellia Serrata Oil Extract, 0.4~1.2 part of sodium monofluorophosphate, 0.2~1.5 part of chlorine hydroxy Al allantoin and 0.5~2.2 part of aminocaproic acid.The toothpaste can kill oral helicobacter pylori, inhibit the symptoms such as canker sore, gum bleeding, and can strong dentine.The preparation method only needs to grind cream processed after mixing each raw material component, technical maturity, easy to control, is conducive to large-scale production.
Description
Technical field
The invention belongs to field of toothpaste, and in particular to a kind of toothpaste and its system for preventing canker sore, inhibiting helicobacter pylori
Preparation Method.
Background technique
Oral cavity helicobacter pylori can not only lead to mouth disease, moreover it is possible to lead to the generation of related stomach trouble, so hair in time
Now and to remove intraoral helicobacter pylori be most important.Helicobacter pylori is not only present on gum and subgingival plaque
In, also there is presence in saliva, level in gingival sulcus fluid and tongue fur, remaining helicobacter pylori can be attached to oral pocket or tooth bacterium in oral cavity
On spot, then stomach entered by diet or other approach.Due to clinically only focusing on helicobacter pylori in stomach at present
It eradicates, without paying attention to influence of the oral cavity Helicobacter pylori infection to patient body, and then leads to stomach pylorus spiral shell in clinic
The recurrence rate for revolving bacillus infection is very high, therefore ought to pay attention to the prevention and treatment and elimination of oral cavity helicobacter pylori.
Notification number is that the patent of CN103908423B proposes a kind of anti-oral helicobacter pylori Chinese medicinal toothpaste, effective component packet
Include Forsythoside, RHIZOMA FAGOPYRI CYMOSI glucoside, tea polyphenols, enoxolone, lactoferrin, Phytic acid lanthanum bismuth and enzyme preparation, the Chinese medicinal toothpaste energy
Oral helicobacter pylori is effectively killed, dental plaque is inhibited and remove.But the Chinese medicinal toothpaste is formulated many and diverse, higher cost.
Summary of the invention
It is of the existing technology in order to solve the problems, such as, prevent canker sore, inhibition helicobacter pylorus the present invention provides a kind of
Toothpaste of bacterium and preparation method thereof.The toothpaste effective component simplifies, is with strong points, can effectively prevent the taste of helicobacter pylori
It is raw, oral environment is purified, dentine is enhanced.The preparation method only needs to grind cream processed, technique after mixing each raw material component
It is mature, easy to control, be conducive to large-scale production.
The solution of the present invention is to provide a kind of toothpaste for preventing canker sore, inhibiting helicobacter pylori, includes following weight
The raw material of part: 1~3 part of Boswellia Serrata Oil Extract, 0.4~1.2 part of sodium monofluorophosphate, 0.2~1.5 part of chlorine hydroxy Al allantoin and ammonia
0.5~2.2 part of base caproic acid.
Preferably, the described toothpaste for preventing canker sore, inhibiting helicobacter pylori further includes the raw material of following parts by weight: being protected
20~48 parts of humectant, 20~48 parts of rubbing agent, 0.5~2.0 part of adhesive, 1.8~2.5 parts of foaming agent, thickener 0.8~1.5
Part, 0.2~1.0 part of sweetener, 0.1~0.5 part of flavouring agent and 7~9 parts of deionized water.
Preferably, the described toothpaste for preventing canker sore, inhibiting helicobacter pylori includes the raw material of following parts by weight: olibanum
2 parts of oil extract, 0.8 part of sodium monofluorophosphate, 0.8 part of chlorine hydroxy Al allantoin, 1.3 parts of aminocaproic acid, 34 parts of moisturizer, friction
34 parts of agent, 1.2 parts of adhesive, 4.1 parts of foaming agent, 1.1 parts of thickener, 0.6 part of sweetener, 0.3 part of flavouring agent and deionized water 8
Part.
Preferably, the moisturizer is any one or the combination of several of them in xylitol, sorbierite or glycerol；It is described to rub
Liniment is the combination of one or more of calcium carbonate, calcium monohydrogen phosphate or anhydride silica；Described adhesive is that carboxymethyl is fine
Tie up the combination of one or both of plain sodium or hydroxyapatite；The foaming agent is sodium lauryl sulfate, N- lauroyl flesh
The combination of one or more of propylhomoserin sodium, methyl cocoa ester group sodium taurocholate or acyl glutamic acid sodium；The thickener is sea
The combination of one or more of mosanom, yellow gum powder or hydroxypropyl guar gum；The sweetener is saccharin sodium, sucrose, sugar
The combination of one or more of essence, honey element or Aspartame；The flavouring agent is Mint Essence, perilla herb oil or lemon sesame oil
One or more of combination.
Preferably, the preparation method of the Boswellia Serrata Oil Extract includes the following steps:
(1) it will be crushed after the freezing of Boswellia carterii resin, and heating melting obtains olibanum viscosity flow liquid to viscosity flow；
(2) heating and refluxing extraction after mixing olibanum viscosity flow liquid with distilled water, and phegma is concentrated, obtain olibanum oil extract
Object.
Preferably, in step (1), the temperature of the freezing is -10~-5 DEG C, and the time of freezing is 10~12h.
Preferably, in step (1), the temperature of the heating melting is 50~110 DEG C.
Preferably, in step (2), the mode of the refluxing extraction are as follows: mix olibanum viscosity flow liquid with distilled water, olibanum is viscous
The weight ratio of flow liquid and distilled water be 1:8~12, be heated to reflux 1.2~1.8h under the conditions of 65~70 DEG C, after filter
Phegma and a filter residue；A filter residue is mixed with distilled water again, the weight ratio of a filter residue and distilled water be 1:6~
10, be heated to reflux 0.8~1.2h under the conditions of 70~80 DEG C, after filter secondary returning flow liquid and to discard filter residue；Merge one
Secondary phegma and secondary returning flow liquid and to be concentrated into olibanum oil content in phegma be 40~60wt.% to get Boswellia Serrata Oil Extract.
The present invention also provides a kind of prevention canker sore, the preparation method for the toothpaste for inhibiting helicobacter pylori: will be each
Agitation grinding, degassing are after raw material mixing to get the toothpaste for preventing canker sore, inhibiting helicobacter pylori.
Preferably, the milling time is 15~30min.
The invention has the benefit that
1, the toothpaste of the present invention for preventing canker sore, inhibiting helicobacter pylori, formula science act on mutual association
Together, in which: be directed to helicobacter pylori, the Boswellia Serrata Oil Extract of addition is able to suppress it and grows and pass through the permeability for influencing cell
Bacterium is further killed, to block sticking for helicobacter pylori and mouth epithelial cells, reduces its pathogenic；In view of mouth
The presence of chamber helicobacter pylori can deteriorate oral environment, cause the symptoms such as canker sore, gum bleeding, therefore addition is able to suppress fibre
Fibrillarin dissolution and the aminocaproic acid for playing anastalsis, can effectively contain oral cavity oozing of blood；At the same time, add
The chlorine hydroxy Al allantoin added can also promote cell Proliferation and wound healing, play the role of deep protection oral cavity；And single fluorine phosphorus
The addition of sour sodium can play the role of tooth increasing intensity and acid resistance, can effectively prevent to decay tooth.To sum up gained, the present invention
The toothpaste component is indispensable, and effect is complemented each other, and can effectively prevent the growth of helicobacter pylori, purifies oral environment, increases
Strong dentine.
2, the preparation method of the toothpaste of the present invention for preventing canker sore, inhibiting helicobacter pylori, it is only necessary to Jiang Geyuan
Expect grinding cream processed after component mixing, it is technical maturity, easy to control, be conducive to large-scale production.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
It is including as follows the present embodiment provides a kind of preparation method of toothpaste for preventing canker sore, inhibiting helicobacter pylori
Step:
(I) Boswellia Serrata Oil Extract is prepared, is included the following steps:
(1) it is crushed after Boswellia carterii resin being freezed 10h under the conditions of -10 DEG C, and is heated to 50 DEG C until resin viscosity flow, obtained
Olibanum viscosity flow liquid；
(2) olibanum viscosity flow liquid is mixed with distilled water by weight 1:8, is heated to reflux 1.2h under the conditions of 70 DEG C, finishes
After filter to obtain a phegma and a filter residue；A filter residue is mixed with distilled water by weight 1:6 again, under the conditions of 80 DEG C
Be heated to reflux 0.8h, after filter secondary returning flow liquid and to discard filter residue；Merge a phegma and secondary returning flow liquid and dense
Being reduced to olibanum oil content in phegma is 40wt.% to get Boswellia Serrata Oil Extract.
(II) toothpaste that preparation prevents canker sore, inhibits helicobacter pylori, the method is as follows:
By 10g Boswellia Serrata Oil Extract, 12g mono-fluor phosphate, 2g chlorine hydroxy Al allantoin, 22g aminocaproic acid, 200g xylose
Alcohol, 480g calcium carbonate, 5g sodium carboxymethylcellulose, 25g sodium lauryl sulfate, 8g sodium alginate, 10g saccharin sodium, 1g peppermint
Essence and 90g deionized water mixing after in vacuum Manufacturing medicine extract machine agitation grinding 15min, after the completion in vacuum degassing machine at degassing
Reason, finally in sterile filling, packaging to get the toothpaste for preventing canker sore, inhibiting helicobacter pylori.
Embodiment 2
It is including as follows the present embodiment provides a kind of preparation method of toothpaste for preventing canker sore, inhibiting helicobacter pylori
Step:
(I) Boswellia Serrata Oil Extract is prepared, is included the following steps:
(1) it is crushed after Boswellia carterii resin being freezed 12h under the conditions of -5 DEG C, and is heated to 110 DEG C until resin viscosity flow, obtained
Olibanum viscosity flow liquid；
(2) olibanum viscosity flow liquid is mixed with distilled water by weight 1:12, is heated to reflux 1.8h under the conditions of 65 DEG C, finishes
After filter to obtain a phegma and a filter residue；A filter residue is mixed with distilled water by weight 1:10 again, in 70 DEG C of conditions
Under be heated to reflux 1.2h, after filter secondary returning flow liquid and to discard filter residue；Merge a phegma and secondary returning flow liquid simultaneously
Being concentrated into olibanum oil content in phegma is 60wt.% to get Boswellia Serrata Oil Extract.
(II) toothpaste that preparation prevents canker sore, inhibits helicobacter pylori, the method is as follows:
By 30g Boswellia Serrata Oil Extract, 4g mono-fluor phosphate, 15g chlorine hydroxy Al allantoin, 5g aminocaproic acid, 480g sorb
Alcohol, 200g calcium monohydrogen phosphate, 20g hydroxyapatite, 18g N- sodium lauroyl sarcosine, 15g Huang gum powder, 2g sucrose, 5g purple perilla
Oil and 70g deionized water mixing after in vacuum Manufacturing medicine extract machine agitation grinding 30min, after the completion in vacuum degassing machine at degassing
Reason, finally in sterile filling, packaging to get the toothpaste for preventing canker sore, inhibiting helicobacter pylori.
Embodiment 3
It is including as follows the present embodiment provides a kind of preparation method of toothpaste for preventing canker sore, inhibiting helicobacter pylori
Step:
(I) Boswellia Serrata Oil Extract is prepared, is included the following steps:
(1) it is crushed after Boswellia carterii resin being freezed 11h under the conditions of -8 DEG C, and is heated to 80 DEG C until resin viscosity flow, obtained
Olibanum viscosity flow liquid；
(2) olibanum viscosity flow liquid is mixed with distilled water by weight 1:10, is heated to reflux 1.5h under the conditions of 67 DEG C, finishes
After filter to obtain a phegma and a filter residue；A filter residue is mixed with distilled water by weight 1:8 again, under the conditions of 75 DEG C
Be heated to reflux 1h, after filter secondary returning flow liquid and to discard filter residue；Merge a phegma and secondary returning flow liquid and is concentrated
Into phegma, olibanum oil content is 50wt.% to get Boswellia Serrata Oil Extract.
(II) toothpaste that preparation prevents canker sore, inhibits helicobacter pylori, the method is as follows:
By 20g Boswellia Serrata Oil Extract, 8g mono-fluor phosphate, 8g chlorine hydroxy Al allantoin, 13g aminocaproic acid, 340g glycerol,
340g anhydride silica, 6g sodium carboxymethylcellulose, 6g hydroxyapatite, 22g methyl cocoa ester group sodium taurocholate, 11g hydroxyl
Propyl guar gum, 6g saccharin, 3g lemon sesame oil and 80g deionized water mixing after in vacuum Manufacturing medicine extract machine agitation grinding 22min, it is complete
After in vacuum degassing machine degassing process, finally sterile filling, packaging to get prevention canker sore, inhibit helicobacter pylorus
The toothpaste of bacterium.
Embodiment 4
It is including as follows the present embodiment provides a kind of preparation method of toothpaste for preventing canker sore, inhibiting helicobacter pylori
Step:
(I) Boswellia Serrata Oil Extract is prepared, the preparation method is the same as that of Example 1.
(II) toothpaste that preparation prevents canker sore, inhibits helicobacter pylori, the method is as follows:
By 10g Boswellia Serrata Oil Extract, 4g mono-fluor phosphate, 2g chlorine hydroxy Al allantoin, 5g aminocaproic acid, 100g xylose
Alcohol, 100g sorbierite, 150g calcium carbonate, 50g anhydride silica, 5g sodium carboxymethylcellulose, 18g acyl glutamic acid sodium, 4g
In vacuum after sodium alginate, 4g Huang gum powder, 2g honey element, 0.5g Mint Essence, 0.5g perilla herb oil and the mixing of 70g deionized water
Agitation grinding 15min in Manufacturing medicine extract machine, the degassing process in vacuum degassing machine after the completion, finally in sterile filling, packaging to get pre-
Anti- canker sore, the toothpaste for inhibiting helicobacter pylori.
Embodiment 5
The present embodiment provides a kind of preparation methods of toothpaste for preventing canker sore, inhibiting helicobacter pylori, with embodiment 2
It compares, sucrose is only changed to Aspartame, remaining raw material, dosage and operation are constant.
It chooses 8 patients with canker sore to carry out trying out toothpaste of the present invention, wherein male, women each 4, year
It age 25~55 years old, respectively uses a toothpaste sooner or later for each person every day, canker sore situation is observed after continuous 7 days, as a result such as 1 institute of table
Show.
The oral conditions of 1 subject of table front and back on probation
In addition, the feedback information that two oral anomaly persons try out toothpaste of the present invention is chosen again, it is specific as follows:
Case 1
Sun, male, 33 years old；Mr. Sun has tobacco habit, and oral cavity is got angry, and gum pain is respectively brushed teeth 1 time daily morning and evening,
Every time with toothpaste about 1.5g, gum pain disappears after 3 days.
Case 2
Liu, female, 25 years old；Always there is a peculiar smell in Mrs Liu oral cavity of getting up daily, deep disturbed, respectively brushes teeth daily morning and evening 1 time,
Oral peculiar smell weakens after only trying out 2 times, it is proposed that lasting to use.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of toothpaste for preventing canker sore, inhibiting helicobacter pylori, which is characterized in that the raw material comprising following parts by weight:
1~3 part of Boswellia Serrata Oil Extract, 0.4~1.2 part of sodium monofluorophosphate, 0.2~1.5 part of chlorine hydroxy Al allantoin and aminocaproic acid 0.5
~2.2 parts.
2. prevention canker sore according to claim 1, the toothpaste for inhibiting helicobacter pylori, which is characterized in that further include
The raw material of following parts by weight: 20~48 parts of moisturizer, 20~48 parts of rubbing agent, 0.5~2.0 part of adhesive, foaming agent 1.8~
2.5 parts, 0.8~1.5 part of thickener, 0.2~1.0 part of sweetener, 0.1~0.5 part of flavouring agent and 7~9 parts of deionized water.
3. prevention canker sore according to claim 2, the toothpaste for inhibiting helicobacter pylori, which is characterized in that including such as
The raw material of lower parts by weight: 2 parts of Boswellia Serrata Oil Extract, 0.8 part of sodium monofluorophosphate, 0.8 part of chlorine hydroxy Al allantoin, aminocaproic acid
1.3 parts, 34 parts of moisturizer, 34 parts of rubbing agent, 1.2 parts of adhesive, 4.1 parts of foaming agent, 1.1 parts of thickener, 0.6 part of sweetener,
0.3 part and 8 parts of deionized water of flavouring agent.
4. prevention canker sore according to claim 2, the toothpaste for inhibiting helicobacter pylori, which is characterized in that the guarantor
Humectant is any one or the combination of several of them in xylitol, sorbierite or glycerol；The rubbing agent is calcium carbonate, calcium monohydrogen phosphate
Or the combination of one or more of anhydride silica；Described adhesive is in sodium carboxymethylcellulose or hydroxyapatite
One or two kinds of combinations；The foaming agent is sodium lauryl sulfate, N- sodium lauroyl sarcosine, methyl cocoa ester group ox sulphur
The combination of one or more of sour sodium or acyl glutamic acid sodium；The thickener is sodium alginate, yellow gum powder or hydroxypropyl
The combination of one or more of guar gum；The sweetener is in saccharin sodium, sucrose, saccharin, honey element or Aspartame
One or more of combinations；The flavouring agent is the combination of one or more of Mint Essence, perilla herb oil or lemon sesame oil.
5. prevention canker sore according to claim 1, the toothpaste for inhibiting helicobacter pylori, which is characterized in that the cream
The preparation method of sesame oil extract includes the following steps:
(1) it will be crushed after the freezing of Boswellia carterii resin, and heating melting obtains olibanum viscosity flow liquid to viscosity flow；
(2) heating and refluxing extraction after mixing olibanum viscosity flow liquid with distilled water, and phegma is concentrated, obtain Boswellia Serrata Oil Extract.
6. prevention canker sore according to claim 5, the toothpaste for inhibiting helicobacter pylori, which is characterized in that step (1)
In, the temperature of the freezing is -10~-5 DEG C, and the time of freezing is 10~12h.
7. prevention canker sore according to claim 5, the toothpaste for inhibiting helicobacter pylori, which is characterized in that step (1)
In, the temperature of the heating melting is 50~110 DEG C.
8. prevention canker sore according to claim 5, the toothpaste for inhibiting helicobacter pylori, which is characterized in that step (2)
In, the mode of the refluxing extraction are as follows: mix olibanum viscosity flow liquid with distilled water, the weight ratio of olibanum viscosity flow liquid and distilled water is
1:8~12 are heated to reflux 1.2~1.8h under the conditions of 65~70 DEG C, after filter to obtain a phegma and a filter residue；Again
Filter residue is mixed with distilled water, the weight ratio of a filter residue and distilled water is 1:6~10, is heated under the conditions of 70~80 DEG C
Flow back 0.8~1.2h, after filter secondary returning flow liquid and to discard filter residue；Merge a phegma and secondary returning flow liquid and dense
Being reduced to olibanum oil content in phegma is 40~60wt.% to get Boswellia Serrata Oil Extract.
9. the preparation method of the toothpaste of prevention canker sore, inhibition helicobacter pylori described in claim 1~8 is any, special
Sign is that agitation grinding, degassing are after mixing each raw material to get the toothpaste for preventing canker sore, inhibiting helicobacter pylori.
10. the preparation method of the toothpaste according to claim 9 for preventing canker sore, inhibiting helicobacter pylori, feature
It is, the milling time is 15~30min.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368335A (en) * | 2019-06-25 | 2019-10-25 | 安徽宝利行香料有限公司 | Application of the Olibanum extract in oral cavity bacteriostatic composition |
| CN110522670A (en) * | 2019-09-21 | 2019-12-03 | 广州市可优美科技有限公司 | A kind of long-acting anti-helicobacter pylori toothpaste |
| CN111568812A (en) * | 2020-05-22 | 2020-08-25 | 烟台新时代健康产业日化有限公司 | Toothpaste for inhibiting helicobacter pylori and preparation method thereof |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
| CN113855601A (en) * | 2021-11-05 | 2021-12-31 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation and use method thereof |
| IT202000016639A1 (en) * | 2020-07-09 | 2022-01-09 | Daniele Scetta | COMPOSITION FOR USE IN THE TREATMENT OF ESOPHAGEAL BURNING AND/OR PAIN ASSOCIATED WITH GASTROESOPHAGEAL REFLUX DISORDER OR DISEASE. |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485575A (en) * | 2017-08-30 | 2017-12-19 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
| CN108670889A (en) * | 2018-07-25 | 2018-10-19 | 佛山市仁汇医药科技有限公司 | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
-
2018
- 2018-11-01 CN CN201811295646.1A patent/CN109125144A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485575A (en) * | 2017-08-30 | 2017-12-19 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| CN108670889A (en) * | 2018-07-25 | 2018-10-19 | 佛山市仁汇医药科技有限公司 | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer |
Non-Patent Citations (4)
| Title |
|---|
| 孙绍曾: "《新编实用日用化学品制造技术》", 31 October 1996, 化学工业出版社 * |
| 无: "LG竹盐精品全优护牙膏紫竹盐全面健康口腔", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_A320171893.HTML》 * |
| 李玉红等: "天然植物乳香胶体外抗幽门螺杆菌有效成分筛选", 《中国药业》 * |
| 果酱音乐: "韩国的牙医诊所，可能都因为这款牙膏垮掉了…", 《HTTPS://WWW.SOHU.COM/A/203719160_487844》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368335A (en) * | 2019-06-25 | 2019-10-25 | 安徽宝利行香料有限公司 | Application of the Olibanum extract in oral cavity bacteriostatic composition |
| CN110522670A (en) * | 2019-09-21 | 2019-12-03 | 广州市可优美科技有限公司 | A kind of long-acting anti-helicobacter pylori toothpaste |
| CN111568812A (en) * | 2020-05-22 | 2020-08-25 | 烟台新时代健康产业日化有限公司 | Toothpaste for inhibiting helicobacter pylori and preparation method thereof |
| IT202000016639A1 (en) * | 2020-07-09 | 2022-01-09 | Daniele Scetta | COMPOSITION FOR USE IN THE TREATMENT OF ESOPHAGEAL BURNING AND/OR PAIN ASSOCIATED WITH GASTROESOPHAGEAL REFLUX DISORDER OR DISEASE. |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
| CN113855601A (en) * | 2021-11-05 | 2021-12-31 | 福州幽力克生物科技有限公司 | Toothpaste capable of inhibiting helicobacter pylori and preparation and use method thereof |
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