CN110522670A - A kind of long-acting anti-helicobacter pylori toothpaste - Google Patents
A kind of long-acting anti-helicobacter pylori toothpaste Download PDFInfo
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Abstract
The present invention relates to a kind of long-acting anti-helicobacter pylori toothpaste, be made of following parts by weight of component: plant extracts lysozyme 0.77-1.53%, latex extract lactoferrin 0.77-2.30%, isatis root extract 0.77-2.30%, forsythia suspense extraction 0.77-2.30%, licorice 0.77-2.30%, bletilla striata extract 0.77-2.30% and aminocaproic acid 0.77-2.30%, remaining is toothpaste body matrix.The present invention potent can kill and long-acting inhibition oral helicobacter pylori, goes to eliminate bad breath, removes plaque and the strong dentine of energy, keeps the hygiene and health in oral cavity, it plays and prevents the firewall that helicobacter pylori enters stomach, simple process simultaneously, process is few, and production cost is low.
Description
Technical field
The invention belongs to effect field of toothpaste, and in particular to a kind of long-acting anti-helicobacter pylori toothpaste.
Background technique
Since China's eating habit is the system of having meal with, cause in oral cavity all kinds of bacteriums very easily by having meal with when tableware and provision room
It mutually transmits and enters oral cavity, and postprandial most of do not brush teeth is gargled, therefore more constantly breeds bacterium, helicobacter pylori
It is exactly the most common mushroom propagated by oral cavity.Most of all, know together according to international gastroenterology medicine, stomach infections pylorus
Pylori and gastric cancer and gastric ulcer are at high correlation, and the infected of China's helicobacter pylori accounts for about 60~70%,
Through becoming the severely afflicated area of Helicobacter pylori infection, incidence gastric cancer rate is in world's umber one.So killing and long-acting inhibition oral cavity
Interior helicobacter pylori is most important.It is very urgent to prevent and treat stomach Helicobacter pylori infection.Helicobacter pylori infection
Treatment have three or tetrad effects of antibiotics it is rather good, but prevent it is ineffective always, repeated healing after again because having meal with once again
Infection.Therefore, there is a kind of potent lengthening effect to kill in the oral cavity very urgent with the toothpaste of helicobacter pylori is inhibited！
Notification number is that the patent of CN103908423B proposes a kind of anti-oral helicobacter pylori Chinese medicinal toothpaste, effective component packet
Include Forsythoside, RHIZOMA FAGOPYRI CYMOSI glucoside, tea polyphenols, enoxolone, lactoferrin, Phytic acid lanthanum bismuth and enzyme preparation, main composition
For lactoferrin, there are better effects to inhibition oral helicobacter pylori and dental plaque.But potent killing degree wretched insufficiency, and be formulated
More with complex process process, cost is very high, and promotion effect is very poor.
Summary of the invention
In order to solve the problems existing in the prior art, the present invention provides a kind of long-acting anti-helicobacter pylori toothpaste.The tooth
Cream with potent plant lysozyme can effective percentage 98% kill helicobacter pylori and can promote with long-acting lactoferrin double
Discrimination bacillus hyperplasia and inhibit helicobacter pylori, reach potent with the long-acting oral health benefits combined.The preparation method
It only needs to mix each raw material component, stirring, deaerates, is filling, simple process, process is few, at low cost, proper scale metaplasia
It produces.
The solution of the present invention is to provide a kind of long-acting anti-helicobacter pylori toothpaste, includes Effect raw material weight ratio are as follows: plant
Extract lysozyme 1~1.53%, latex extract lactoferrin 0.77-2.30%, isatis root extract 0.77-2.30%,
Forsythia suspense extraction 0.77-2.30%, licorice 0.77-2.30%, bletilla striata extract 0.77-2.30% and aminocaproic acid
0.77-2.30%, remaining is toothpaste body matrix.
Preferably, the toothpaste body matrix are as follows: rubbing agent 7.66-22.99%, moisturizer 7.66-22.99%, foaming agent
1.15-1.92%, thickener 0.38-1.15%, adhesive 0.38-1.53%, sweetener 0.38-1.15% and deionized water
3.83-7.66%.
Preferably, a kind of toothpaste of long-acting anti-helicobacter pylori includes effect raw material and basic raw material mixing weight
Amount is than formula are as follows: plant extract lysozyme 1.53%, isatis root extract 1.38%, connects plant extract lactoferrin 2.30%
Stick up extract 1.15%, licorice 1.38%, bletilla striata extract 0.92% and aminocaproic acid 0.92%, rubbing agent
22.99%, moisturizer 22.99%, foaming agent 1.69%, thickener 0.77%, adhesive 0.77% and deionized water 5.75%.
Preferably, rubbing agent is silica or/and calcium carbonate；Foaming agent is sodium lauryl sulfate or/and acyl group paddy
Propylhomoserin sodium；Moisturizer is xylitol or/and glycerol；Thickener is xanthan gum or/and sodium alginate；Adhesive is carboxymethyl cellulose
Plain sodium.
Preferably, plant extracts lysozyme is plant extracts lysozyme frankincense oil.
Preferably, the lysozyme is extracted by Burseraceae gum olibanum, and preparation methods steps are as follows:
(1) olibanum resin is successively obtained after drying, freezing, crushing and heating to olibanum liquid；
Preferably, in step (1), the cryogenic temperature that the olibanum liquid extracts is between -12~-3 DEG C.Heating temperature is 55
~100 DEG C.
(2) olibanum liquid addition 1:10 distilled water is stirred, is heated after stirring using reflux extraction, then passes through two
Secondary reflux filter residue, finally concentration obtains Boswellia Serrata Oil Extract.
Preferably, in step (2), the olibanum oil extract uses reflux extraction, and heating temperature is 60~80 DEG C, concentration
20~40% frankincense oil of content must be extracted.
Preferably, the present invention provides a kind of long-acting anti-helicobacter pylori toothpaste and preparation method thereof mixes each raw material,
Stirring deaerates, is filling, and simple process, process is few, and production cost is low, is suitble to promote.
The invention has the benefit that
1, to solve the problems, such as effect limitation and high production cost of the existing technology, the present invention provides a kind of long-acting
Anti-helicobacter pylori toothpaste.There is the toothpaste potent plant extract lysozyme frankincense oil to include pentacyclic triterpene, tetracyclic triterpene
Its adhesion with oral mucosa is reduced to molten degradation helicobacter pylori cell membrane with bioactivity enzymes such as macrocyclic diterpenes
And play potent killing helicobacter pylori.
2, long-acting lactoferrin can promote Bifidobacterium hyperplasia, and Bifidobacterium is that gram-positive bacteria can effectively inhibit deep and remote
The growth of door pylori, by the lactoferrin remained between tooth, constantly promote the growth of probiotic bifidobacteria to
Reach and keeps potent with helicobacter pylori killing effect in the long-acting oral cavity combined in oral cavity.The preparation method only need by
Each raw material component mixing, deaerates, is filling at stirring, and simple process, process is few, at low cost, suitable for scale production.
3, long-acting anti-helicobacter pylori toothpaste of the present invention, two kinds of effects inhibit helicobacter pylori cytosis,
Play mutually it is potent combined with long-acting, can effectively prevent helicobacter pylori growth, can it is potent killing and long-acting inhibition oral cavity
Helicobacter pylori goes to eliminate bad breath, removes plaque and the strong dentine of energy, keeps the hygiene and health in oral cavity, play and prevent pylorus spiral shell
Spinner handle bacterium enters the firewall of stomach.
4, the preparation method of a kind of long-acting anti-helicobacter pylori toothpaste of the invention, it is only necessary to each raw material be mixed, stirring, taken off
Gas, filling, simple process, process is few, and production cost is low, is suitble to promote.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Case study on implementation in the present invention belongs to protection scope of the present invention below even without the other embodiment of narration.
A kind of long-acting anti-helicobacter pylori toothpaste of the invention, is made: plant extracts bacteriolyze of following parts by weight of component
Enzyme 0.77-1.53%, latex extract lactoferrin 0.77-2.30%, isatis root extract 0.77-2.30%, Fructus Forsythiae extract
Object 0.77-2.30%, licorice 0.77-2.30%, bletilla striata extract 0.77-2.30% and aminocaproic acid 0.77-
2.30%, remaining is toothpaste body matrix.
Specifically, long-acting anti-helicobacter pylori toothpaste further includes the toothpaste body matrix of following components: rubbing agent 7.66-
22.99%, moisturizer 7.66-22.99%, foaming agent 1.15-1.92%, thickener 0.38-1.15%, adhesive 0.38-
1.53% and deionized water 3.83-7.66%.
Embodiment 1
Prepare a kind of toothpaste of common long-acting anti-helicobacter pylori, the method is as follows:
By frankincense oil 20g, lactoferrin 30g, isatis root extract 18g, forsythia suspense extraction 15g, licorice 18g,
Bletilla striata extract 12g and aminocaproic acid 12g, silica 300g, sodium lauryl sulfate 40g, xylitol or glycerol 300g, Huang
Virgin rubber 10g, sodium carboxymethylcellulose 10g and deionized water 70g.It is mixed in stirring in vacuum Manufacturing medicine extract machine, vacuum outgas, filling,
Up to the toothpaste of the long-acting anti-helicobacter pylori of plain edition.
In the present embodiment, the lysozyme of long-acting anti-helicobacter pylori toothpaste is extracted by Burseraceae gum olibanum, and method includes
Following steps:
1, lysozyme is extracted by Somalia's Burseraceae gum olibanum, and preparation methods steps are as follows:
(1) olibanum resin is successively obtained after drying, freezing, crushing and heating to olibanum liquid；By Boswellia carterii resin-
Under the conditions of 12 DEG C freeze 6h after crush, and slow heat to 75 DEG C olibanum liquid；
(2) olibanum liquid addition 1:10 distilled water is stirred, is heated after stirring using reflux extraction, then passes through two
Secondary reflux filter residue, finally concentration obtains to obtain 20~40% frankincense oil of content.
Embodiment 2
A kind of toothpaste of long-acting anti-helicobacter pylori of potent type is prepared, main method is to improve lactoferrin concentration, specifically
It is formulated as follows:
By frankincense oil 20g, lactoferrin 50g, isatis root extract 18g, forsythia suspense extraction 15g, licorice 18g,
Bletilla striata extract 12g and aminocaproic acid 12g, silica 300g, sodium lauryl sulfate 40g, xylitol or glycerol 300g, Huang
Virgin rubber 10g, sodium carboxymethylcellulose 10g and deionized water 70g.It is mixed in stirring in vacuum Manufacturing medicine extract machine, vacuum outgas, filling,
Up to the toothpaste of the long-acting anti-helicobacter pylori of potent type.
Compared with Example 1, due to improving lactoferrin amount, the growth for inhibiting oral bacteria can more be continued, especially
It is that polydonita bacterial plaque personage is especially needed, important hints are that have certain human body mucous membrane corrosivity because of frankincense oil,
The use of olibanum oil concentration can not arbitrarily be improved.
Embodiment 3
A kind of toothpaste of long-acting anti-helicobacter pylori of delicate fragrance type is prepared, main method is to improve Radix Glycyrrhizae, Radix Isatidis and flavouring
Agent peppermint oil, specific formula are as follows:
By frankincense oil 20g, lactoferrin 30g, isatis root extract 25g, peppermint oil 0.5g, forsythia suspense extraction 15g, Radix Glycyrrhizae
Extract 30g, bletilla striata extract 12g and aminocaproic acid 12g, silica 300g, sodium lauryl sulfate 40g, xylitol or
Glycerol 300g, xanthan gum 10g, sodium carboxymethylcellulose 10g and deionized water 70g.It is mixed in stirring, vacuum in vacuum Manufacturing medicine extract machine
Degassing, the filling toothpaste to get the long-acting anti-helicobacter pylori of delicate fragrance type,
Compared with Example 1, make oral cavity since raising Radix Glycyrrhizae, Radix Isatidis concentration can solve removing abnormal flavor in oral cavity and increase peppermint oil
It is pure and fresh nice and cool, it is vigorous to oral peculiar smell and internal heat especially to need.
Embodiment 4
A kind of toothpaste of long-acting anti-helicobacter pylori of brilliant white type is prepared, main method is to improve silica concentration, specifically
It is formulated as follows:
By frankincense oil 20g, lactoferrin 30g, isatis root extract 18g, forsythia suspense extraction 15g, licorice 18g,
Bletilla striata extract 12g and aminocaproic acid 12g, silica 400g, sodium lauryl sulfate 40g, xylitol or glycerol 300g, Huang
Virgin rubber 10g, sodium carboxymethylcellulose 10g and deionized water 70g.It is mixed in stirring in vacuum Manufacturing medicine extract machine, vacuum outgas, filling,
Up to the toothpaste of the long-acting anti-helicobacter pylori of brilliant white type,
Compared with Example 1, the friction to enamel surface can be increased due to improving silica concentration, to tooth Huang, tooth
Bacterial plaque and dental calculus have more removal effects, especially need to enamel jaundice, but unsuitable excessive use in case injury normally
Enamel.
In conclusion only a specific embodiment of the invention, but scope of protection of the present invention is not limited thereto, including
There are many be not limited only to frankincense oil, any technology model stated in the present invention for being familiar with the art for plant extracts lysozyme
In enclosing, it should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the guarantor of the claim
It protects subject to range.
Claims (9)
1. a kind of long-acting anti-helicobacter pylori toothpaste, it is characterised in that: be made of following parts by weight of component: plant extracts bacteriolyze
Enzyme 0.77-1.53%, latex extract lactoferrin 0.77-2.30%, isatis root extract 0.77-2.30%, Fructus Forsythiae extract
Object 0.77-2.30%, licorice 0.77-2.30%, bletilla striata extract 0.77-2.30% and aminocaproic acid 0.77-
2.30%, remaining is toothpaste body matrix.
2. anti-helicobacter pylori toothpaste according to claim 1, it is characterised in that: toothpaste body matrix are as follows: rubbing agent 7.66-
22.99%, moisturizer 7.66-22.99%, foaming agent 1.15-1.92%, thickener 0.38-1.15%, adhesive 0.38-
1.53% and deionized water 3.83-7.66%.
3. long-acting anti-helicobacter pylori toothpaste according to claim 2, it is characterised in that: the plant extract lysozyme
1.53%, plant extract lactoferrin 2.30%, isatis root extract 1.38%, forsythia suspense extraction 1.15%, licorice
1.38%, bletilla striata extract 0.92% and aminocaproic acid 0.92%, rubbing agent 22.99%, foaming agent 1.69%, moisturizer
22.99%, thickener 0.77%, adhesive 0.77% and deionized water 5.75%.
4. long-acting anti-helicobacter pylori toothpaste according to claim 2, it is characterised in that: rubbing agent be silica or/
And calcium carbonate；Foaming agent is sodium lauryl sulfate or/and acyl glutamic acid sodium；Moisturizer is xylitol or/and glycerol；Thickening
Agent is sodium alginate or/and xanthan gum；Adhesive is sodium carboxymethylcellulose.
5. long-acting anti-helicobacter pylori toothpaste according to claim 1, it is characterised in that: plant extracts lysozyme is to plant
Object extract lysozyme frankincense oil.
6. long-acting anti-helicobacter pylori toothpaste according to claim 1, it is characterised in that: the lysozyme is by Burseraceae cream
Fragrant natural gum extracts frankincense oil, and preparation methods steps are as follows:
(1) by olibanum resin, olibanum liquid is successively obtained after drying, freezing, crushing and heating；
(2) olibanum liquid addition 1:10 distilled water is stirred, is heated after stirring using reflux extraction, then passes through secondary returning
Filter residue is flowed, finally concentration obtains Boswellia Serrata Oil Extract.
7. long-acting anti-helicobacter pylori toothpaste according to claim 6, it is characterised in that: the freezing that the olibanum liquid extracts
Temperature is between -16~-3 DEG C, and slow heat temperature is 55~100 DEG C.
8. long-acting anti-helicobacter pylori toothpaste according to claim 6, which is characterized in that the frankincense oil is mentioned using reflux
It follows the example of, heating temperature is 60~80 DEG C, and extracting frankincense oil levels is 20~40%.
9. according to claim 1, long-acting anti-helicobacter pylori toothpaste described in 6,7 or 8, it is characterised in that: the lysozyme packet
Include frankincense oil.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
| CN111053718A (en) * | 2019-12-31 | 2020-04-24 | 合肥赛为智慧医疗有限公司 | Mouthwash with function of resisting helicobacter pylori in oral cavity |
| CN111249399A (en) * | 2020-04-01 | 2020-06-09 | 森淼科技(嘉兴)有限公司 | Oral HP antibacterial cream and production process thereof |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
| CN111803628A (en) * | 2020-07-24 | 2020-10-23 | 尤丽康（江苏）生物医药有限公司 | Helicobacter pylori resisting compound preparation |
| CN111904886A (en) * | 2020-07-27 | 2020-11-10 | 王祥 | Oral cavity antibacterial cream and preparation method thereof |
| CN112022775A (en) * | 2020-10-13 | 2020-12-04 | 福州比格艾普科技有限公司 | Oral care product for resisting helicobacter pylori |
| CN112316123A (en) * | 2020-12-03 | 2021-02-05 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN112870144A (en) * | 2021-01-25 | 2021-06-01 | 铜陵沐妤贸易有限公司 | Oral care product for resisting helicobacter pylori |
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| CN103908423A (en) * | 2014-04-24 | 2014-07-09 | 上海利康消毒高科技有限公司 | Anti-oral helicobacter pylori traditional Chinese medicine toothpaste |
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| CN111053718A (en) * | 2019-12-31 | 2020-04-24 | 合肥赛为智慧医疗有限公司 | Mouthwash with function of resisting helicobacter pylori in oral cavity |
| CN111000752A (en) * | 2020-01-06 | 2020-04-14 | 陕西润和堂医药有限公司 | Traditional Chinese medicine toothpaste for resisting helicobacter pylori |
| CN111249399A (en) * | 2020-04-01 | 2020-06-09 | 森淼科技(嘉兴)有限公司 | Oral HP antibacterial cream and production process thereof |
| CN111714625A (en) * | 2020-07-14 | 2020-09-29 | 湖南大海医药集团有限公司 | Antibacterial paste for killing or inhibiting helicobacter pylori in oral cavity and preparation method thereof |
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| CN111803628B (en) * | 2020-07-24 | 2021-05-14 | 尤丽康（江苏）生物医药有限公司 | Helicobacter pylori resisting compound preparation |
| CN111904886A (en) * | 2020-07-27 | 2020-11-10 | 王祥 | Oral cavity antibacterial cream and preparation method thereof |
| CN112022775A (en) * | 2020-10-13 | 2020-12-04 | 福州比格艾普科技有限公司 | Oral care product for resisting helicobacter pylori |
| CN112316123A (en) * | 2020-12-03 | 2021-02-05 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for resisting helicobacter pylori infection and preparation method and application thereof |
| CN112870144A (en) * | 2021-01-25 | 2021-06-01 | 铜陵沐妤贸易有限公司 | Oral care product for resisting helicobacter pylori |
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