CN110772598A

CN110772598A - Composition for treating aphtha, application and taking method thereof

Info

Publication number: CN110772598A
Application number: CN201911091375.2A
Authority: CN
Inventors: 侯小兵; 夏晶晶; 张梓岗; 肖爱萍; 陈国宝; 戴琴花; 肖淑珍
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-10
Filing date: 2019-11-10
Publication date: 2020-02-11

Abstract

The invention discloses a composition for treating aphtha, a preparation method and a use method thereof, wherein the composition comprises calcined gypsum, natural indigo, human urine sediment, human Chinese rhubarb, borneol, raw astragalus root, gentian, phellodendron bark, bletilla striata, catechu, raw cattail pollen, mint and raw liquorice, the monarch drug in the formula is calcined gypsum, natural indigo, human urine sediment, human Chinese rhubarb, borneol and raw astragalus root, and the ministerial drug is gentian, phellodendron bark, bletilla striata, catechu and raw cattail pollen; the adjuvant comprises herba Menthae and Glycyrrhrizae radix. The formula can effectively treat acute and chronic aphthous stomatitis and gum and throat ulceration and gall through the synergistic effect of different components and the monarch, minister, assistant and guide compatibility of the traditional Chinese medicine components, has small side effect and high treatment speed, and can quickly relieve symptoms.

Description

Composition for treating aphtha, application and taking method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a composition for treating aphtha, application and an administration method thereof.

Background

Canker sores, also known as "canker sores", are painful ulcer points that appear on the mucous membranes of the oral cavity, such as the inner lip, palate and cheek, in a circular or oval shape. It is usually found on the mucous membrane of the lips, cheeks, soft palate or gum of the mouth, where the ulcer surface is usually circular or oval, concave, white or yellow, with reddish and swollen congestion in the center and around, and obvious pain.

Oral ulcer is a common oral mucosa disease, and the incidence rate is high in China at present. The < trial implementation of a guide for diagnosing and treating recurrent aphthous ulcer published in 2012 of China shows that 10-25% of people suffer from recurrent oral ulcer, and the good-onset age is 10-30 years old. The female prevalence rate is generally higher than that of the male, and the disease can be developed all the year round.

Oral ulcers are of three types: the first is recurrent oral ulcer, also called recurrent aphthous ulcer and recurrent oral ulcer, and the most important characteristic is recurrent attacks, with intervals and self-healing. The second is traumatic oral ulcer, including mechanical injury, chemical burn, and cold and hot stimulation. The third is oral ulcer accompanied by disease: many more serious diseases, such as Behcet's disease, Reiter's syndrome, tumors, etc. with ulcer, are one of the main manifestations of the disease or one of the secondary lesions. Before and after the ulcer appears, the general manifestations of malignant diseases may appear, and the comprehensive judgment should be performed in combination with other diseases to avoid delaying the disease condition.

The basic causes include genetic factors, immunological factors, mental factors, dietary factors, traumatic factors or induction factors, etc. Wherein the genetic factors are: canker sores are closely linked to inheritance and investigations have shown that about 40% of patients have a family history of canker sores. The immune factors are as follows: the body is vulnerable to pathogen invasion due to the reduction of immunity, so that oral ulcer is caused; meanwhile, immune protein is consumed in the immune reaction process, so that the immune balance state of the oral cavity is broken, and the occurrence of oral ulcer is accelerated. The mental factors are: when the mental stress of people is large, negative emotions such as dysphoria, anxiety, tension and the like are easy to generate, the sleeping quality is poor, the immune function of the organism is reduced, and the oral ulcer is easy to be infected by virus. The diet factors are: food preference can lead to unbalanced intake of nutrients such as vitamins (iron, zinc, folic acid and vitamin B) in human body, and oral ulcer. For example, zinc is an important component of various enzymes in the body, can influence the division and regeneration of cells, reduces the synthesis of digestive mucin of oral mucosa, and causes the oral mucosa to strip and cause diseases. Traumatic factors are: the most common physical injuries are scratches or abrasion caused by eating sharp foods (such as potato chips, fishbones, seafood with shells and the like), the false bite of the teeth, the scratches of tooth sockets and toothbrushes when the teeth are corrected, and the like, which are all easy to damage the mucous membranes of the wound cavities to cause dental ulcers. The induction factors are: when the content of progesterone in serum before menstrual period is low, ulcer of oral mucosa is easy to occur.

The pain is severe when the oral ulcer is attacked, the local burning pain is obvious, and serious patients can influence diet and speaking, thereby causing great inconvenience to daily life; can be used for treating halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, asthenia, dysphoria, fever, and lymphadenectasis.

The existing method for treating aphtha is generally medication, and the existing treatment medicines generally comprise analgesic medicines, anti-inflammatory medicines, healing promotion medicines, other local medicines, immune preparations or vitamins. However, the existing therapeutic drugs cannot meet the requirements of quick response and small side effect and cannot meet the requirements of patients.

Disclosure of Invention

In view of the above, there is a need to provide a composition for treating aphtha, a preparation method and a use method thereof.

The composition for treating aphtha comprises calcined gypsum, natural indigo, human urine sediment, human yellow sediment, borneol, raw astragalus, gentian, golden cypress, bletilla, catechu, raw cattail pollen, mint and raw liquorice.

Preferably, the composition for treating aphtha comprises, by weight, 27-33 parts of calcined gypsum, 7-13 parts of natural indigo, 4-8 parts of homo, 4-8 parts of tabasheer, 4-8 parts of borneol, 7-13 parts of raw astragalus, 2.7-3.3 parts of gentian, 4-6 parts of golden cypress, 7-13 parts of rhizoma bletillae, 2.7-3.3 parts of catechu, 4-6 parts of raw cattail pollen, 4-6 parts of mint and 4-6 parts of raw licorice.

Preferably, the composition for treating aphtha comprises, by weight, 30 parts of calcined gypsum, 10 parts of indigo naturalis, 6 parts of homo, 6 parts of borneol, 10 parts of raw astragalus, 3 parts of gentian, 5 parts of cortex phellodendri, 10 parts of rhizoma bletillae, 3 parts of catechu, 5 parts of raw pollen typhae, 5 parts of mint and 5 parts of raw liquorice.

Preferably, the composition for treating aphtha further comprises red firewire, garden burnet root, tiger ginger, chestnut bark and ginkgo root.

Preferably, the composition for treating aphtha comprises, by weight, 27-30 parts of calcined gypsum, 8 parts of indigo naturalis, 6-7 parts of homo, 6-7 parts of tabasheer, 6-7 parts of borneol, 8 parts of raw astragalus membranaceus, 2 parts of gentian, 4 parts of golden cypress, 10-13 parts of bletilla, 2.4 parts of catechu, 4 parts of raw cattail pollen, 6 parts of mint, 8 parts of raw licorice, 2-4 parts of red hawksbeard, 5-7 parts of garden burnet, 10-15 parts of kadsura root, 11-13 parts of chestnut bark and 8 parts of ginkgo root.

The invention also provides a preparation method of the composition for treating aphtha, which comprises the following steps: s1: taking corresponding traditional Chinese medicinal materials according to the formula and the weight parts; s2: respectively micronizing the above Chinese medicinal materials into powder of 1-100 μm; s3: mixing the above Chinese medicinal powders, and bottling.

The invention also provides a preparation method of the composition for treating aphtha, which comprises the following steps:

s01: taking traditional Chinese medicinal materials of calcined gypsum, indigo naturalis, felwort, golden cypress, catechu, raw cattail pollen and raw liquorice according to a formula, fully crushing the traditional Chinese medicinal materials respectively in a crusher to obtain powder, and uniformly mixing the powder according to the corresponding weight parts of the formula to obtain a powder mixture A for later use;

s02: respectively taking raw astragalus, bletilla striata and mint according to the weight part requirement of the formula, crushing the astragalus by using a crusher according to the weight part, adding 4-6 times of sterile water for mixing, then adding into a leaching tank, introducing steam for heating to 95 ℃, preserving heat for 30 minutes, continuously stirring during heating and heat preservation, then filtering to remove astragalus residue, and cooling the obtained astragalus leaching liquor for later use; juicing mint by a wall breaking machine to obtain mint juice for later use, fully crushing bletilla striata by a crusher to obtain bletilla striata powder, and uniformly mixing the bletilla striata powder with the mint juice to obtain a mixture B for later use;

s03: uniformly mixing the powder mixture A, the astragalus leaching liquor and the mixture B through a mixer, adding 1-2 parts of yeast and 1 part of acetobacter, uniformly mixing, putting into a fermentation tank, fermenting at the temperature of 30-35 ℃ for 18-32 hours to obtain a mixture C;

s04: adding 2-3 parts of acetobacter into the mixture C, uniformly mixing, and putting into a fermentation tank, wherein the fermentation temperature is 28-30 ℃, and the fermentation time is 24-48 hours, so as to obtain a mixture D;

s05, drying the mixture D, micronizing into 1-100 μm, and packaging into blow-molded bottles.

s101: according to the formula, the traditional Chinese medicinal materials of calcined gypsum, indigo naturalis, felwort, phellodendron amurense, catechu, raw cattail pollen, raw liquorice, red fire rope, chestnut bark and ginkgo root are respectively and fully crushed by a crusher to obtain powder, and corresponding parts by weight are taken according to the formula and are uniformly mixed to obtain a powder mixture A for later use;

s102: pulverizing radix astragali in parts by weight with a pulverizer, mixing with 4-6 times of sterile water, adding into a leaching tank, introducing steam, heating to 95 deg.C, keeping the temperature for 30 min, stirring while heating and keeping the temperature, filtering to remove radix astragali residue, and cooling the obtained radix astragali extract; pulverizing radix Sangusorbae by weight parts with a pulverizer, adding 5-8 times of sterile water, mixing, adding into a leaching tank, introducing steam, heating to 85 deg.C, keeping the temperature for 50 min, stirring while heating and keeping the temperature, filtering to remove radix Sangusorbae residue, cooling the obtained radix Sangusorbae leaching solution, and squeezing herba Menthae to obtain herba Menthae juice; sufficiently crushing the bletilla striata in a crusher to obtain bletilla striata powder; juicing the saxifrage ginger through a wall breaking machine to obtain saxifrage ginger juice for later use, and uniformly mixing the bletilla striata powder, the mint juice and the saxifrage ginger juice to obtain a mixture B for later use;

s103: uniformly mixing the powder mixture A, the astragalus membranaceus leaching liquor, the sanguisorba officinalis leaching liquor and the mixture B through a mixer, adding 2-3 parts of yeast and 1-2 parts of bacillus aceticus, uniformly mixing, putting into a fermentation tank, and fermenting at the temperature of 30-35 ℃ for 22-36 hours to obtain a mixture C;

s104: adding 3 parts of acetobacter into the mixture C, uniformly mixing, putting into a fermentation tank, and fermenting at 25-30 ℃ for 48 hours to obtain a mixture D;

s105, drying the mixture D, micronizing into 1-120 μm, and filling into a blow-molded bottle.

The invention also discloses a use method of the composition for treating aphtha, which is sprayed on an affected part 3-4 times per day.

The invention also discloses a use method of the composition for treating aphtha, which is matched with decoction for synergistic treatment and comprises the following use steps: the decoction is administered half an hour before the composition for treating aphtha is sprayed on the affected part, and the above process is repeated 3-4 times per day;

the decoction is water decoction of fresh leaves of Hypericum perforatum and honeysuckle stem; the preparation method of the daily decoction comprises the following steps:

s201: putting the fresh leaves of the hypericum perforatum and the fresh leaves of the honeysuckle stem into a frying pan, wherein the weight of the fresh leaves of the hypericum perforatum and the fresh leaves of the honeysuckle stem are both 50g, namely the weight ratio of the fresh leaves of the hypericum perforatum to the fresh leaves of the honeysuckle stem is 1: 1;

s202: adding water, decocting for two times, soaking the medicinal materials for 25-35 min when the water overflows 3-5cm for the first time, decocting with strong fire, decocting with slow fire for 25 min after boiling, and pouring out the medicinal liquid to obtain water decoction A;

during the second decoction, the water amount is equal to that of the first decoction, the first decoction is carried out by strong fire, the second decoction is carried out by slow fire for 25 minutes after the first decoction is boiled, and the liquid medicine is poured out to obtain a water decoction B;

s203: mixing the water decoction A and the water decoction B to obtain decoction, and taking the decoction 3-4 times.

Compared with the prior art, the invention has the following advantages.

The formula of the invention combines tonification and purgation, is used in warm and cool, accords with the compatibility principle of monarch, minister, assistant and guide among the raw material medicines, and the calcined gypsum has the functions of clearing away heat and toxic material, astringing and promoting granulation, natural indigo, human urine sediment, human yellow sediment and borneol have the functions of purging pathogenic fire, cooling blood, reducing swelling and relieving pain, and the raw astragalus root has the functions of tonifying qi and supporting sore; radix Gentianae, cortex Phellodendri, rhizoma Bletillae, Catechu, radix Ophiopogonis, herba Menthae, and Glycyrrhrizae radix.

The traditional Chinese medicine composition can meet the requirements of patients on the medicines by matching various traditional Chinese medicines or traditional Chinese medicine components through the dialectical treatment principle of the traditional Chinese medicine in the aspect of practical application, and not only can take effect quickly, but also can meet the requirement of small side effect. The whole formula is reasonable in design and accords with the syndrome differentiation and treatment principle and the compatibility principle of the traditional Chinese medicine.

The monarch drugs in the formula are calcined gypsum, indigo naturalis, human urine sediment, human yellow sediment, borneol and raw astragalus membranaceus, and the ministerial drugs are gentian, golden cypress, bletilla striata, catechu and raw cattail pollen; the adjuvant comprises herba Menthae and Glycyrrhrizae radix. The formula can effectively treat acute and chronic aphthous stomatitis and gum and throat ulceration and gall through the synergistic effect of different components and the monarch, minister, assistant and guide compatibility of the traditional Chinese medicine components, has small side effect and high treatment speed, and can quickly relieve symptoms.

Further, the monarch drug of the invention is calcined gypsum, natural indigo, white ginseng, yellow ginseng, borneol, raw astragalus, garden burnet root and tiger ginger, and the ministerial drug is gentian, phellodendron, bletilla, catechu, raw cattail pollen, red firedrake and chestnut bark; the adjuvants include herba Menthae, Glycyrrhrizae radix, and radix Ginkgo. The formula can effectively treat acute and chronic aphthous stomatitis and gum and throat ulceration and gall through the synergistic effect of different components and the monarch, minister, assistant and guide compatibility of the traditional Chinese medicine components, has small side effect and high treatment speed, and can quickly relieve symptoms.

Furthermore, the invention improves the bioavailability of the whole components by a fermentation method, upgrades the formula by saccharomycetes and acetobacter on the premise of meeting the requirement of improving the bioavailability without influencing the curative effect and improving the using effect, can solve the problems of small side effect and high treatment speed, and can quickly relieve symptoms.

Furthermore, the invention can be matched from inside to outside by matching the water decoction, thereby further improving the treatment speed and meeting the requirements of patients.

The calcined gypsum in the formula is white powder or loose blocks, and the surface of the calcined gypsum is reddish and opaque. Light weight, soft, fragile, and crumbly into powder. Without bad smell, bland taste, it is used to astringe dampness, promote granulation, heal wound and stop bleeding. It can be used for treating unhealed ulcer, eczema, pruritus, scald due to hot water and fire, and traumatic hemorrhage.

The indigo in the formula is dry powder, lumps or particles prepared by processing leaves or stems and leaves of Strobilanthes cusia of Acanthaceae, Polygonum tinctorium of Polygonaceae and Isatis tinctoria of Cruciferae. The nature and taste are salty and cold, and the medicine has the efficacies of clearing away heat and toxic material, cooling blood and removing ecchymoses, purging fire and arresting convulsion and the like. It is mainly used for treating epidemic febrile disease with excessive heat, macula, hematemesis, hemoptysis, pharyngalgia, aphtha, infantile convulsion, sore, swelling, erysipelas, snake and insect bite, etc.

The urine sediment of the human urine in the formula is a solid substance naturally precipitated in the urine of a healthy human in the family of human beings, and has the effects of clearing heat, reducing pathogenic fire, stopping bleeding and removing blood stasis. It is commonly used for consumptive lung disease, excessive heat, hematemesis, epistaxis, pharyngitis, ulcerative gingivitis, aphtha, ulcer of the mouth and tongue, various damp ulcers, burn and scald.

The Chinese rhubarb is the product of licorice powder soaked in human excrement pit for certain time inside a bamboo tube. Has the effects of clearing heat, cooling blood, purging fire and removing toxicity. It is commonly used for pyretic diseases, epidemic febrile disease with macula, fever with polydipsia, acne with blood heat, erysipelas, and pyocutaneous disease.

The borneol in the formula of the invention, named as borneol, orange slice, blumea, borneol, tomatillo, bornyl alcohol, plum ice and the like, is prepared by steam distillation and recrystallization of stems and leaves of blumea balsamifera of Compositae or branches and leaves of camphor of Camphora camphora of Lauraceae, and is also prepared by a series of chemical processes on turpentine. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer.

The astragalus root used in the general health care or treatment of the raw astragalus root in the formula of the invention refers to raw astragalus root, one of the common traditional Chinese medicines is the root of astragalus mongholicus or astragalus membranaceus of leguminous plants. Is prepared into decoction pieces and is blended into a traditional Chinese medicine preparation.

The gentian in the formula belongs to platycodon, and perennial herbs in adenophora have stems which are single-grown, are more than 50 cm to 1 m high and have no hair or long hard hair. Has the effects of purging excessive fire of liver and gallbladder and removing damp-heat in lower-jiao, has good effect on the treatment of diseases such as hypertension, dizziness, cholecystitis, hepatitis and the like, and is a rare traditional Chinese medicine.

The phellodendron bark in the formula is the dried bark of phellodendron chinense of Rutaceae. It is commonly called Chuan Huang Bai. Can be used for treating dysentery due to damp-heat, jaundice, dark urine, leukorrhagia, pudendal pruritus, stranguria with heat, tinea pedis, atrophic debility cramped, hectic fever, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema.

The common bletilla pseudobulb in the formula is used for hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease and pyogenic infections and skin chapping.

The catechu in the formula is a leguminous plant, and has the effects of promoting blood circulation, relieving pain, stopping bleeding, promoting granulation, astringing dampness, healing sore, clearing lung and eliminating phlegm. Can be used for treating traumatic injury, traumatic hemorrhage, hematemesis, epistaxis, unhealing pyocutaneous disease, eczema, and cough due to lung heat.

The cattail pollen in the formula is relatively common cattail of typhaceae, namely dry pollen of cattail, water candle, cattail pollen, pollen of pulchella centifolia and the like, the cattail has thick and strong stems on the ground, is tapered upwards, has strip-shaped leaves, is tightly connected with male and female inflorescences, and has the flower and fruit period of 5-8 months. Generally, the yellow male inflorescence on the cattail pollen is collected in summer, then dried in the sun, and screened after being rolled, so that the traditional Chinese medicine cattail pollen is prepared. The common processing method of Chinese herbs also affects the efficacy, and different methods for processing the same herb also have different efficacies. The cattail pollen generally comprises raw cattail pollen and cattail pollen charcoal. The processing method of pollen Typhae and charred pollen Typhae is different, and the pollen Typhae is prepared by pulverizing, agglomerating, and sieving.

The mint in the formula is named as 'Yindancao' in the local name, is a labiate plant, namely other dry whole herbs in the same genus, mostly grows beside the river of the mountain wetland, roots and roots grow transversely and underground, is a sweating and heat-relieving medicine, and is used for treating symptoms such as influenza, headache, conjunctival congestion, body fever, throat, gum swelling and pain and the like.

The raw licorice in the formula of the invention refers to the dry product of the root and rhizome of the medicinal plant licorice. Has effects in invigorating qi, strengthening middle warmer, relieving spasm and pain, moistening lung, relieving cough, clearing pathogenic fire, removing toxic substances, regulating the functions of the above drugs, relieving fatigue, anorexia, emaciation, sallow complexion, palpitation, short breath, abdominal pain, loose stool, spasm and pain of limbs, hysteria, cough, asthma, sore throat, carbuncle, sore, infantile carbuncle, and food poisoning.

The red fire rope in the formula is deciduous shrub or small tree, leaves grow mutually, leaves are oval or wide oval, the parasol inflorescence is axillary, and the red fire rope is provided with a plurality of flowers and seeds with wings. Distributed in Guangxi, Guizhou, Yunnan, etc. Can be used for treating traumatic hemorrhage, fracture, burn, scald, chronic gastritis, and gastric ulcer.

The sanguisorba officinalis in the formula is named as sanguisorba officinalis, cynanchum wilfordii and sanguisorba officinalis, is a perennial herb with the height of 20-30 cm, and is a plant in Geranium of Geraniaceae. The root is used as the medicine, and has the effects of clearing heat, promoting diuresis, promoting blood circulation and stopping bleeding. Can be used for treating enteritis, dysentery, dyspepsia, chronic gastritis, menoxenia, epistaxis, and traumatic injury by external application.

The tiger ginger in the formula disclosed by the invention is the rhizome of polygonatum sibiricum of liliaceae, mostly grows in mountain areas, is collected in spring and autumn to remove stems, leaves and fibrous roots, is cleaned, sliced and dried in the sun for medical use, and is similar to but different from ginger in shape. Moisten lung and nourish yin, invigorate spleen and replenish qi, dispel phlegm and stop bleeding, resolve swelling and remove toxicity.

The chestnut bark in the formula is the bark of chestnut in the fagaceae plant, and has the effects of detoxifying, reducing swelling, astringing and stopping bleeding. It is commonly used for scabies, erysipelas, aphtha, dermatitis, hemafecia, epistaxis, traumatic hemorrhage, traumatic injury pain.

The semen ginkgo biloba root in the formula is the root of a Chinese dive tree or a light-leaf Chinese dive tree of a Chinese dive tree plant of the family of Chinese dive. Has the effects of astringing to stop bleeding and stopping diarrhea. It is commonly used for various kinds of bleeding and diarrhea.

The hypericum perforatum in the formula is a perennial herb of hypericum of Guttiferae, and has the height of up to centimeter and no hair. Upright stem, multiple branches, petioless leaf, elliptic to linear leaf, blunt tip, full edge, back curl, green upper surface, white green lower surface, sparse and unobvious pulse network. Hypericum perforatum is bitter, pungent and neutral in flavor, and can clear heat and remove toxicity, regulate menstruation and stop bleeding. The whole plant can be inserted into the leaf, and the Hypericum perforatum is inserted into the medicine by the dry overground part, is bitter, astringent and neutral in taste, has the effects of soothing the liver, resolving depression, clearing heat, promoting diuresis, reducing swelling and relieving pain, and is mainly used for treating symptoms such as stagnation of qi, depression, joint swelling and pain, dysuria and the like.

The honeysuckle stem in the formula is dry stems of honeysuckle of the family Caprifoliaceae. In the attached prescriptions of compendium, it means that there are many leaves of vine, and it is the assistant syndrome that the whole body of Lonicera is precious, and the vine, leaves and flowers can be used as the medicine, and the three herbs have the same properties and taste, and are pungent, sweet and cold. The honeysuckle stem and the honeysuckle have similar chemical components and pharmacological activity. It is used to treat epidemic febrile disease, fever, dysentery, infectious hepatitis, carbuncle, swelling, sore, and arthralgia and myalgia.

Detailed Description

The present invention is further illustrated by the following examples.

Example 1

The composition for treating aphtha comprises calcined gypsum, natural indigo, human urine sediment, human yellow sediment, borneol, raw astragalus root, gentian, phellodendron bark, bletilla, catechu, raw cattail pollen, mint and raw liquorice.

Example 2

The composition for treating aphtha comprises, by weight, 27-33 parts of calcined gypsum, 7-13 parts of indigo naturalis, 4-8 parts of homo, 4-8 parts of borneol, 7-13 parts of raw astragalus membranaceus, 2.7-3.3 parts of felwort, 4-6 parts of golden cypress, 7-13 parts of rhizoma bletillae, 2.7-3.3 parts of catechu, 4-6 parts of raw cattail pollen, 4-6 parts of mint and 4-6 parts of raw liquorice.

Example 3

The composition for treating aphtha comprises, by weight, 30 parts of calcined gypsum, 10 parts of indigo naturalis, 6 parts of human urine sediment, 6 parts of human yellow sediment, 6 parts of borneol, 10 parts of raw astragalus membranaceus, 3 parts of felwort, 5 parts of golden cypress, 10 parts of rhizoma bletillae, 3 parts of catechu, 5 parts of raw cattail pollen, 5 parts of mint and 5 parts of raw liquorice.

Example 4

The composition for treating aphtha also comprises red firecrackers, garden burnet root, tiger ginger, chestnut bark and ginkgo root.

Example 5

The composition for treating aphtha comprises, by weight, 27-30 parts of calcined gypsum, 8 parts of indigo naturalis, 6-7 parts of homo, 6-7 parts of borneol, 8 parts of raw astragalus membranaceus, 2 parts of gentian, 4 parts of golden cypress, 10-13 parts of bletilla, 2.4 parts of catechu, 4 parts of raw pollen typhae, 6 parts of mint, 8 parts of raw liquorice, 2-4 parts of red hawthorne, 5-7 parts of garden burnet, 10-15 parts of kadsura japonica, 11-13 parts of chestnut bark and 8 parts of ginkgo root.

Example 6

The preparation method of the composition for treating aphtha comprises the following steps: s1: taking corresponding traditional Chinese medicinal materials according to the formula and the weight parts; s2: respectively micronizing the above Chinese medicinal materials into powder of 1-100 μm; s3: mixing the above Chinese medicinal powders, and bottling.

Wherein the formulation components of the composition for treating aphtha are in accordance with any one of the regimens of examples 1-5.

Example 7

The preparation method of the composition for treating aphtha comprises the following steps:

Wherein the formulation components of the composition for treating aphtha are in accordance with any one of the regimens of examples 1-3.

Example 8

Wherein the formulation components of the composition for treating aphtha are in accordance with any one of the regimens of examples 4-5.

Example 9

The application method of the composition for treating aphtha is that the composition is sprayed on the affected part 3-4 times per day.

Wherein the formulation components of the composition for treating aphtha are prepared according to the protocol of any one of examples 6 to 8.

Example 10

The application method of the composition for treating aphtha, disclosed by the invention, is matched with decoction for carrying out synergistic treatment, and comprises the following application steps: the decoction is administered half an hour before the composition for treating aphtha is sprayed on the affected part, and the above process is repeated 3-4 times per day;

the decoction is water decoction of fresh leaves of herba Hyperici perforati and caulis Lonicerae; the preparation method of the daily decoction comprises the following steps:

s202: adding water, decocting for two times, soaking for 25-35 min when the water overflows 3-5cm, decocting with strong fire, decocting with slow fire for 25 min after boiling, and pouring out the medicinal liquid to obtain water decoction A;

Example 11

For Qin-jiao, male, age 54, the physician needs to see the tongue with pain for three days: the tongue edge and the tongue tip are congested with blood, the right tongue edge has an oval ulcer focus with a size of about 0.8x0.5cm, and the pain (+) is chewed. Red tongue with white and greasy coating and wiry pulse, and the traditional Chinese medicine diagnosis: western diagnosis of aphtha wind-heat riding spleen: ulcer of tongue mucosa.

The formula of the example 2 is used, and the aphtha powder prepared by the preparation method of the example 6 is matched, so that the aphtha powder is uniformly applied to an ulcer surface, three times a day, a patient is ordered to close the mouth for 10 minutes after external application, the tongue pain disappears after 3 days, and the ulcer surface is healed.

Example 12

Li Shi, male, 23 years old, because "recurrent oral ulcer is treated for two days", the patient usually has oral ulcer, bad food intake, attacks every month, and is treated after staying up for nearly two days, the oral pain is obvious, find: congestion of oral mucosa, multiple white ulcer foci on palate and tongue bottom, congestion and red swelling of mucosa around the ulcer foci. Red tongue with thin yellow coating and rapid pulse. Traditional Chinese medicine diagnosis: aphtha: western diagnosis of heart-spleen heat accumulation: recurrent oral ulceration.

The formula of the example 3 is used, the preparation method of the example 6 is matched, the prepared aphtha powder is uniformly sprayed and externally applied for 3 days, 3 times are carried out every day, most ulcer ranges basically disappear, the food intake is not obstructed, the aphtha powder is applied for two days for healing, and relapse does not occur in one month.

Example 13

Zhangzhi, female, 34 years old, for "two days of sore throat after eating spicy" visit the doctor: congestion of pharyngeal mucosa, elevated lymph follicles and obvious congestion on the posterior pharyngeal wall, II degrees on the tonsils on both sides, and the epiglottis is lifted up under indirect laryngoscope without peeping at the glottis. A red tongue with thin, greasy coating and a superficial and rapid pulse. Traditional Chinese medicine: acute pharyngitis and wind-heat in the external system of western medicine: acute pharyngitis.

The formula of the example 5 is used, the preparation method of the example 6 is matched, the prepared aphtha powder is sprayed on the pharyngeal posterior wall for 2 days, the pain is obviously relieved, the aphtha powder is continuously applied for two days, the pain is not obvious, and the oral cavity is normally eaten.

Example 14

Xue should be taken after 9 years old, and the patient should be examined for fever due to "restlessness and food refusal 1 day": the oral mucosa, uvula and isthmus on both sides are full of small herpes with diameter of 2-3mm, and the areola around the herpes is obvious. The red tongue with thin yellow coating and thready and rapid pulse. Traditional Chinese medicine diagnosis: acute pharyngitis: and (3) diagnosing the wind-heat attacking the external western medicine: herpangina.

The formula in the embodiment 2 is used, the preparation method in the embodiment 7 is matched, the prepared aphtha powder is physically cooled, the aphtha powder is externally applied to herpes twice a day after gargling, the mouth of a patient is closed for 10 minutes after external application, the medicine powder is fully absorbed, the herpes disappears nearly half a day after 3 days, and the herpes basically disappears after continuous external application for 3 days.

Example 15

For example, for a patient in age 45 who is old 45 and old Zhu Chi, the patient is admitted to the hospital for bilateral tonsil dissection because of chronic tonsillitis for one week, and is discharged after anti-inflammatory and hemostatic treatment for three days. After eating today, the patient vomits a little blood silk, red in color, and looks: the white membranes in the two side fossa venosa are covered and slightly congested with blood, while the white membranes in the upper part of the left fossa venosa are loose and show bloody exudates. Dark tongue, white and greasy coating, wiry and slippery pulse. Traditional Chinese medicine diagnosis: combining phlegm and blood stasis of the tonsillitis with western medicine: and bleeding after tonsil operation.

The formula of the example 3 is used, the preparation method of the example 7 is matched, the aphtha powder is sprayed on the loose part of the white membrane of the left side fossa, the fluid diet of the patient is ordered twice a day, the blood streak disappears after 3 days, and the white membrane of the left side fossa is checked to be in place without blood exudates.

Example 16

For example, the patient is aged for 2 years old and 2 days old, and is examined: the gums, palate, lips spread with white debris and spread toward the throat. The periphery of the white crumb is surrounded by reddish halos which are adhered to each other, and the white crumb is like solidified milk blocks, can grow along with wiping and is not easy to remove. Taking a little of the white dander, and coating an electron microscope to detect hypha and sporophyte of the fungus. Pale-red with thin coating and thready and rapid pulse. Traditional Chinese medicine diagnosis: western diagnosis of thrush heat accumulated in heart and spleen: mycotic stomatitis.

The formula of the example 5 is used, the aphtha powder prepared by the preparation method of the example 8 is matched, the aphtha powder is sprayed on the white dandruff part and externally applied, 2-3 times a day, 2% sodium bicarbonate solution is used for cleaning the oral cavity before each application, and the oral cavity is healed after 5 days.

Example 17

Liu Zhi, female, age 16, for diagnosis and examination of "angina 1 day": bilateral tonsils are congested with III ° of blood, the surface is like mulberry, purulent secretion is seen, the pharyngeal posterior wall is congested, and the middle and lower larynx is normal. A red tongue with thin and yellow coating and a slippery and rapid pulse. Traditional Chinese medicine diagnosis: and (3) diagnosing whether the wind-heat of the rotten tonsillitis externally attacks western medicine: acute suppurative tonsillitis.

The aphtha powder prepared by using the formula of the embodiment 5 and the preparation method of the embodiment 8 is used for anti-inflammatory treatment by a therapist, the externally applied tonsil is sprayed on the aphtha powder, and the decoction is matched with the decoction, so that purulent secretion disappears after 2 days, and pharyngalgia is relieved.

Example 18

Zhang Jia, female, 74 years old, will be treated more heavily for two days due to "repeating gum herpes for more than half a year". Patients have a history of diabetes, the herpes gingivae recurs in the last half year, the patients are usually treated by self-administration of vitamin B12, the improvement is not seen, and the following two days are examined: the lips of the gums showed small white blisters with more saliva. The tongue is pale red, the coating is thin, white and the pulse is thin. Traditional Chinese medicine diagnosis: western diagnosis of aphtha and spleen deficiency and excessive dampness: recurrent herpetic gingivitis.

The formula of the embodiment 5 is used, the preparation method of the embodiment 8 is matched, the prepared aphtha powder is used for carrying out external application treatment on the aphtha powder, 2-3 times a day, herpes basically disappears after 3 days, the oral mucosa is slightly painful, the aphtha powder is changed into external application once before sleep, the decoction is matched with the water decoction of the invention, and the aphtha powder is healed after 3 days of insistence, and no relapse occurs in one month.

Example 19

The composition for treating aphtha comprises, by weight, 27-30 parts of calcined gypsum, 8 parts of indigo naturalis, 6-7 parts of homo, 6-7 parts of tabasheer, 6-7 parts of borneol, 8 parts of raw astragalus, 2 parts of gentian, 4 parts of golden cypress, 10-13 parts of bletilla, 2.4 parts of catechu, 4 parts of raw pollen typhae, 6 parts of mint, 8 parts of raw liquorice, 2-4 parts of red hawkstroemia, 5-7 parts of sanguisorba officinalis, 10-15 parts of kadsura japonica, 11-13 parts of chestnut bark, 8 parts of ginkgo root, 6-8 parts of radix sophorae flavescentis, 5-7 parts of mulberry leaf, 10-12 parts of semen plantaginis, 5-7 parts of chrysanthemum, 3 parts of cortex moutan, 5-6 parts of radix scrophulariae and 6-8 parts of dandelion.

s101: according to the formula, Chinese medicinal materials of calcined gypsum, indigo naturalis, felwort, golden cypress, catechu, raw cattail pollen, raw liquorice, red-fire-rope, chestnut bark, mountain ginkgo root, mulberry leaf, sophora flavescens, plantain seed and chrysanthemum are respectively and fully crushed in a crusher to obtain powder, and corresponding parts by weight are taken according to the formula and are uniformly mixed to obtain a powder mixture A for later use;

s102: pulverizing radix astragali in parts by weight with a pulverizer, mixing with 4-6 times of sterile water, adding into a leaching tank, introducing steam, heating to 95 deg.C, keeping the temperature for 30 min, stirring while heating and keeping the temperature, filtering to remove radix astragali residue, and cooling the obtained radix astragali extract;

pulverizing radix Sangusorbae by weight parts with a pulverizer, mixing with 5-8 times of sterile water, adding into leaching tank, introducing steam, heating to 85 deg.C, maintaining the temperature for 50 min, stirring while heating and maintaining the temperature, filtering to remove radix Sangusorbae residue, cooling the obtained radix Sangusorbae leaching solution,

mixing radix scrophulariae, herba Taraxaci and cortex moutan according to weight parts, and pulverizing with a pulverizer to obtain mixed powder for later use; juicing herba Menthae by wall breaking machine to obtain herba Menthae juice; sufficiently crushing the bletilla striata in a crusher to obtain bletilla striata powder; juicing the tiger ginger through a wall breaking machine to obtain tiger ginger juice for later use, and uniformly mixing the mixed powder, the bletilla powder, the mint juice and the tiger ginger juice to obtain a mixture B for later use;

adding 1-2 parts of EM strain into the mixture D, uniformly mixing, putting into a fermentation tank, fermenting at 35-40 ℃ for 36 hours to obtain a mixture E;

s105, drying the mixture E, micronizing into 1-120 μm, and filling into a blow-molded bottle.

the decoction is water decoction of herba Hyperici perforati fresh leaf, caulis Lonicerae fresh leaf, and semen Persicae; the preparation method of the daily decoction comprises the following steps:

s201: putting the fresh leaves of the hypericum perforatum, the fresh leaves of the honeysuckle stem and the peach kernel into a frying pan, wherein the weight of the fresh leaves of the hypericum perforatum and the fresh leaves of the honeysuckle stem are both 50g, and the weight of the peach kernel is 20-25g, namely the weight ratio of the fresh leaves of the hypericum perforatum, the fresh leaves of the honeysuckle stem to the peach kernel is 1: 1: 0.4-0.5;

Li Shi, female 80 years old, the physician will be treated with the disease for 3 days because of "recurrent gum herpes March, aggravated by 3 days". The patients had repeated outbreaks of gum herpes in about March, and were usually treated with self-administered anti-inflammatory drugs, and no improvement was found: the gum, the lips and the mouth are white and small herpes, the tongue is pale red, the coating is thin, white and thready. Traditional Chinese medicine diagnosis: western diagnosis of aphtha and spleen deficiency and excessive dampness: recurrent herpetic gingivitis.

The aphtha powder prepared by the method is used for external application treatment of aphtha powder, herpes basically disappears 3 times a day after 2 days, and the oral mucosa is slightly painful, and the aphtha powder is matched with the water decoction of the invention, lasts for 3 days, is healed, and has no recurrence within one month.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A composition for treating aphtha, comprising: comprises Gypsum Fibrosum Preparatum, indigo naturalis, homo, Borneolum, radix astragali, radix Gentianae, cortex Phellodendri, rhizoma Bletillae, Catechu, pollen Typhae, herba Menthae and Glycyrrhrizae radix.

2. The composition for treating aphtha according to claim 1, wherein: the traditional Chinese medicine composition comprises, by weight, 27-33 parts of calcined gypsum, 7-13 parts of indigo naturalis, 4-8 parts of Renzhongbai, 4-8 parts of Renzhonghuang, 4-8 parts of borneol, 7-13 parts of raw Astragalus mongholicus, 2.7-3.3 parts of gentian, 4-6 parts of golden cypress, 7-13 parts of bletilla, 2.7-3.3 parts of catechu, 4-6 parts of raw cattail pollen, 4-6 parts of mint and 4-6 parts of raw liquorice.

3. The composition for treating aphtha according to claim 1, wherein: comprises 30 portions of calcined gypsum, 10 portions of natural indigo, 6 portions of Renzhongbai, 6 portions of Renzhonghuang, 6 portions of borneol, 10 portions of raw astragalus root, 3 portions of gentian, 5 portions of phellodendron bark, 10 portions of bletilla, 3 portions of catechu, 5 portions of raw cattail pollen, 5 portions of mint and 5 portions of raw licorice root.

4. The composition for treating aphtha according to claim 1, wherein: also comprises herba Pyracanthae, radix Sangusorbae, rhizoma Zingiberis recens, cortex Castaneae, and radix Ginkgo.

5. The composition for treating aphtha according to claim 4, wherein: the composition comprises, by weight, 27-30 parts of calcined gypsum, 8 parts of indigo naturalis, 6-7 parts of homo, 6-7 parts of tabasheer, 6-7 parts of borneol, 8 parts of raw astragalus membranaceus, 2 parts of felwort, 4 parts of golden cypress, 10-13 parts of rhizoma bletillae, 2.4 parts of catechu, 4 parts of raw pollen typhae, 6 parts of mint, 8 parts of raw liquorice, 2-4 parts of red firepower, 5-7 parts of garden burnet, 10-15 parts of kadsura coccinea, 11-13 parts of bark of tree and 8 parts of root of mountain ginkgo.

6. A method of preparing a composition for the treatment of aphtha according to any one of claims 1 to 5, wherein: the method comprises the following steps: s1: taking corresponding traditional Chinese medicinal materials according to the formula and the weight parts; s2: respectively micronizing the above Chinese medicinal materials into powder of 1-100 μm; s3: mixing the above Chinese medicinal powders, and bottling.

7. A method of preparing a composition for the treatment of aphtha according to any one of claims 1 to 3, characterized in that: the method comprises the following steps:

8. The method for preparing a composition for the treatment of aphtha according to claim 4 or 5, wherein: the method comprises the following steps:

9. The method of using a composition for the treatment of aphthae according to any one of claims 1 to 5, wherein: it is applied to the affected part 3-4 times daily.

10. The method of using a composition for the treatment of aphthae according to any one of claims 1 to 5, wherein: the medicine is matched with decoction for carrying out cooperative treatment, and the using steps are as follows: the decoction is administered half an hour before the composition for treating aphtha is sprayed on the affected part, and the above process is repeated 3-4 times per day;