CN113940979A

CN113940979A - Traditional Chinese medicine composition for treating hand-foot-and-mouth disease, preparation method and application thereof

Info

Publication number: CN113940979A
Application number: CN202111480322.7A
Authority: CN
Inventors: 吕向东
Original assignee: Zhejiang Yanghe Health Management Technology Co ltd
Current assignee: Zhejiang Yanghe Health Management Technology Co ltd
Priority date: 2021-12-06
Filing date: 2021-12-06
Publication date: 2022-01-18

Abstract

The invention provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine formulas. The composition comprises the following raw materials, by weight, 10-18 parts of corydalis tuber, 10-20 parts of coptis chinensis, 14-30 parts of licorice root tip, 10-20 parts of radix rehmanniae, 6-10 parts of scutellaria baicalensis and 4-12 parts of bamboo leaves; the composition can effectively treat the hand-foot-and-mouth disease, can reduce the pain of a patient in the treatment process, and reduces scar residues; in addition, the invention also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, the method screens out impurities in the raw materials by fully extracting the beneficial components in the raw materials so as to improve the medicine property of the prepared composition, and the method is simple and convenient to operate, can reduce the workload of operators and is convenient for batch production.

Description

Traditional Chinese medicine composition for treating hand-foot-and-mouth disease, preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, a preparation method and application thereof.

Background

Hand-foot-and-mouth disease is an infectious disease caused by enteroviruses, and the enteroviruses causing the hand-foot-and-mouth disease are more than 20 types, wherein the most common enteroviruses are coxsackievirus A16 type (Cox A16) and enterovirus 71 type (EV 71). It is usually seen in children under 5 years old, with symptoms of stomachache, anorexia, low fever, small herpes or ulcer in the mouth, most children will heal themselves for about one week, and few children will cause complications such as myocarditis, pulmonary edema, aseptic meningoencephalitis, etc. The death of individual serious children is caused by fast development of the disease, and the effective treatment medicines are mainly used for symptomatic treatment at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which not only can effectively treat the hand-foot-and-mouth disease, but also can reduce the pain of patients in the treatment process and reduce scar residues.

The second purpose of the invention is to provide application of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease in preparing oral liquid, buccal tablets and decoction for treating the hand-foot-and-mouth disease.

The third objective of the present invention is to provide a method for preparing a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, wherein the method screens out impurities in raw materials by fully extracting beneficial components in the raw materials, so as to improve the drug property of the prepared composition, and the method is simple and convenient to operate, and can reduce the workload of operators, so as to facilitate mass production.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which comprises the following raw materials, by weight, 10-18 parts of corydalis tuber, 10-20 parts of coptis chinensis, 14-30 parts of licorice root tip, 10-20 parts of radix rehmanniae, 6-10 parts of scutellaria baicalensis and 4-12 parts of bamboo leaves. The composition adopts reasonable monarch, minister, assistant and guide relationship for compatibility, wherein the monarch drug adopts licorice root tips which are rich in various alkaloids, wherein glycyrrhizic acid is mainly used, and the glycyrrhizic acid has the effects of anti-inflammation and anti-allergic reaction, and can effectively inhibit skin rash and herpes caused by hand-foot-and-mouth disease, thereby alleviating the disease symptoms of patients, and the glycyrrhizic acid can also adjust the internal environment of intestinal tracts, enhance the resistance of human body to enteroviruses, thereby fundamentally inhibiting the disease of the hand-foot-and-mouth disease. The ministerial drugs are selected from rhizoma corydalis, coptis chinensis, radix rehmanniae and scutellaria baicalensis, can assist monarch drugs to have an anti-inflammatory effect, and can also assist monarch drugs to have the effects of activating blood and relieving pain, so that the pain of patients is relieved; the bamboo leaves are selected as adjuvant drugs in the composition, and can reduce the toxicity of drugs such as corydalis tuber in ministerial drugs, thereby reducing the toxic and side effects of the composition.

In a second aspect, the embodiment of the application provides an application of a traditional Chinese medicine composition for treating hand-foot-and-mouth disease in preparation of oral liquid, buccal tablets and decoction for treating hand-foot-and-mouth disease.

In a third aspect, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice root tips to obtain fine powder, soaking the fine powder in ammonia water and adjusting the pH value to obtain an alkali liquor, and adding ethanol into the alkali liquor while performing ultrasonic oscillation to perform reflux extraction to obtain an extracting solution; decocting Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix and folium Bambusae, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease. The method extracts glycyrrhizic acid by using ammonia water, uses ultrasonic oscillation with reasonable power during the extraction process to make glycyrrhizic acid molecules more dissolved in the ammonia water, then adding ethanol for reflux extraction to dissolve glycyrrhizic acid molecules in the ethanol and volatilize along with the ethanol, so as to separate the glycyrrhizic acid molecules from other impurities to obtain glycyrrhizic acid molecules with higher purity, and other medicinal materials are directly decocted for one time or multiple times to dissolve beneficial components in the decoction, and then the obtained decoction is concentrated, to improve the purity of the beneficial components, finally, the concentrated solution and the extracting solution are evenly mixed and dried to obtain solid composition particles, the preparation method not only can effectively extract each beneficial component in the medicinal materials, but also has simple and convenient operation and is convenient for large-scale production of the composition.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the embodiment of the invention provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which is prepared according to a reasonable monarch, minister, assistant and guide relationship, wherein monarch medicines mainly select licorice root tips, and the licorice root tips can effectively inhibit symptoms such as skin eczema, herpes and the like caused by the hand-foot-and-mouth disease, so that the morbidity symptom of the hand-foot-and-mouth disease is relieved, and skin infection caused by over serious morbidity symptom is avoided; in addition, corydalis tuber, coptis root, rehmannia root and scutellaria root are selected as ministerial drugs, so that the treatment effect of monarch drugs is enhanced, and the effects of relieving pain and the like are achieved, so that the pain of a patient in the treatment process is relieved; the bamboo leaves are selected as the adjuvant drugs, and can reduce the toxicity of part of the medicinal materials, so that the toxic and side effects of the finally prepared composition are reduced, and therefore the composition not only has the effect of treating the hand-foot-and-mouth disease, but also can reduce the pain in the treatment process.

Secondly, the embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, the method extracts the glycyrrhizic acid by using ammonia water, ultrasonic oscillation with reasonable power is used during the process, glycyrrhizic acid molecules can be more dissolved in the ammonia water, ethanol is added for reflux extraction, the glycyrrhizic acid molecules are dissolved in the ethanol and volatilize along with the ethanol, so as to be separated from other impurities, the glycyrrhizic acid molecules with higher purity are obtained, other medicinal materials are directly decocted for one or more times, beneficial components are dissolved in the decoction, then the obtained decoction is concentrated, so as to improve the purity of the beneficial components, finally the concentrated solution and the extracting solution are uniformly mixed and dried, so as to obtain solid composition particles, and the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease is obtained, and the preparation method not only can effectively extract each beneficial component in the medicinal materials, and the operation is simple and convenient, and the mass production of the composition is convenient.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a box plot of the time at which the body temperature of a patient returns to normal as provided by a test example of the present invention;

FIG. 2 is a boxplot of the time to regression of herpes in patients provided by a test example of the present invention;

FIG. 3 is a box plot of the time at which the pain sensation subsided in the patient according to the test example of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which comprises the following raw materials, by weight, 10-18 parts of corydalis tuber, 10-20 parts of coptis chinensis, 14-30 parts of licorice root tip, 10-20 parts of radix rehmanniae, 6-10 parts of scutellaria baicalensis and 4-12 parts of bamboo leaves. Rhizoma corydalis is dry tuber of corydalis tuber of Papaveraceae, and is named rhizoma corydalis, etc., and has pungent, bitter, warm nature, liver and spleen channels, and has effects of promoting blood circulation, activating qi-flowing and relieving pain, etc., and is mainly used for treating symptoms such as stagnation of qi and blood; the coptis is a perennial herb of goldthread of ranunculaceae, is called as rhizoma coptidis and the like, is bitter in taste and cold in nature, enters heart, spleen, stomach, liver, gallbladder and large intestine channels, has the effects of clearing heat, drying dampness, purging fire, detoxifying and the like, and is mainly used for treating symptoms such as vomiting, acid regurgitation, damp-heat, fullness and the like; the tip of licorice root is the peripheral part or fine root of the root of licorice root of Leguminosae, and compared with licorice root, the root has lighter weight, better drug effect, higher content of various alkaloids contained in the root, sweet taste, cold nature, heart, small intestine and bladder channels, has the efficacies of antianaphylaxis, anti-inflammation, fire-purging and detoxifying, and is mainly used for treating symptoms such as dermatitis, intestine and stomach obstruction, etc.; radix rehmanniae, is fresh or dried root tuber of rehmannia glutinosa Libosch of Scrophulariaceae, has sweet, bitter and cold properties, and has effects of clearing away heat and toxic materials, cooling blood, promoting fluid production, and treating warm-toxicity macula, fever yin impairment, etc.; the scutellaria baicalensis is a perennial herb of scutellaria in the family of labiatae, is called camellia root and the like, is bitter in taste and cold in nature, enters lung, gallbladder, spleen, large intestine and small intestine channels, has the effects of clearing heat, drying dampness, purging intense heat, detoxifying and the like, and is mainly used for treating symptoms such as damp-heat fullness, high fever, polydipsia and the like; the bamboo leaves are leaves of gramineous plants, such as lophatherum gracile, and the like, are sweet and light in taste and cold in nature, enter heart, lung and stomach channels, have the effects of clearing heat, relieving restlessness and the like, and are mainly used for treating symptoms of yin deficiency, fire excess and the like.

The composition adopts reasonable monarch, minister, assistant and guide relationship for compatibility, wherein the monarch drug adopts licorice root tips which are rich in various alkaloids, wherein glycyrrhizic acid is mainly used, and the glycyrrhizic acid has the effects of anti-inflammation and anti-allergic reaction, and can effectively inhibit skin rash and herpes caused by hand-foot-and-mouth disease, thereby alleviating the disease symptoms of patients, and the glycyrrhizic acid can also adjust the internal environment of intestinal tracts, enhance the resistance of human body to enteroviruses, thereby fundamentally inhibiting the disease of the hand-foot-and-mouth disease. The ministerial drugs are selected from rhizoma corydalis, coptis chinensis, radix rehmanniae and scutellaria baicalensis, can assist monarch drugs to have an anti-inflammatory effect, and can also assist monarch drugs to have the effects of activating blood and relieving pain, so that the pain of patients is relieved; the bamboo leaves are selected as adjuvant drugs in the composition, and can reduce the toxicity of drugs such as corydalis tuber in ministerial drugs, thereby reducing the toxic and side effects of the composition.

In some embodiments of the invention, the traditional Chinese medicine composition for treating hand-foot-and-mouth disease further comprises auxiliary materials, wherein the auxiliary materials comprise, by weight, 8-12 parts of bistort rhizome, 4-12 parts of Chinese ilex leaf, 2-10 parts of mint, 2-10 parts of great burdock achene, 2-10 parts of akebia stem, 5-15 parts of weeping forsythia capsule, 7-15 parts of honeysuckle flower and 3-11 parts of chrysanthemum. The bistort rhizome is a dry rhizome of bistort rhizome of Polygonaceae plant, is bitter and astringent in taste and slightly cold in nature, enters lung, liver and large intestine channels, has the effects of clearing heat and removing toxicity, relieving swelling and removing blood stasis and the like, and is mainly used for treating symptoms such as carbuncle swelling and the like; folium Ilicis Purpureae, the leaf of Aquifoliaceae plant ilex Purpureae, is bitter, astringent and cold in taste, has effects of cooling blood, stopping bleeding, resisting bacteria and diminishing inflammation, and can be used for treating bacillary dysentery and skin infection; the mint is a labiate plant, namely other dry whole herbs belonging to the same genus, namely, the mint is called as the Yindan herb and the like, is pungent in taste and cool in nature, enters lung and liver channels, has the effects of dispelling wind and heat, clearing head and eyes, soothing liver, promoting qi circulation and the like, and is mainly used for treating symptoms such as rubella, pruritus and liver depression and qi stagnation; the fructus Arctii is dry mature fruit of Arctium lappa L.of Ernian herbaceous plant of Compositae, has special flavor of malignant excess, pungent taste, bitter taste, and cold nature, enters lung and stomach channel, has effects of dispelling lung heat, removing toxic substance, promoting eruption, relieving swelling, and treating sore, and can be used for treating symptoms such as measles without adequate eruption and carbuncle swelling and sore; the caulis Akebiae is dry rattan of caulis Akebiae, caulis Akebiae or caulis Akebiae of Lardizabalaceae, and is also called medulla Tetrapanacis, and has bitter taste, cold nature, heart-fire, small intestine and bladder channels, etc., and has effects of clearing heart-fire, relieving restlessness, promoting qi circulation, promoting blood circulation, etc., and can be used for treating damp-heat arthralgia and aphtha of mouth and tongue; fructus forsythiae fruit of Forsythia of Oleaceae is slightly cold in nature and bitter in taste, enters lung, heart and small intestine channels, has effects of clearing heat and detoxicating, subsiding swelling and resolving hard mass, and is mainly used for treating symptoms such as coma, macula, warm heat entering ying, superficial infection, etc.; the honeysuckle is a dried flower bud or a flower with initial blossom of honeysuckle of the Caprifoliaceae family, is called honeysuckle flower and the like, has sweet taste and cold property, enters lung and stomach channels, has the effects of clearing heat and removing toxicity, diminishing inflammation and reducing swelling and the like, and is mainly used for treating symptoms such as epidemic febrile disease, fever, toxic heat, bloody dysentery, carbuncle, furuncle and the like; the chrysanthemum is perennial root herbaceous plant of Compositae and Chrysanthemum, is also called Jinying, and the like, is bitter, sweet and slightly cold in nature, enters lung and liver channels, has the effects of dispelling wind, clearing heat, detoxifying, promoting qi circulation and the like, and is mainly used for treating symptoms such as sore, carbuncle, pyogenic infection and the like.

In the auxiliary materials, fructus forsythiae, bistort rhizome, Chinese ilex leaf, great burdock achene and akebia stem are used as ministerial drugs in the main drug to assist the monarch drugs in the main drug to play roles and play roles in easing pain and inhibiting sore toxicity; the honeysuckle is used as an adjuvant drug in the composition provided by the invention, so that the composition not only has the efficacy of harmonizing the toxicity of medicinal materials, but also can promote the circulation of qi and dredge the intestines to inhibit intestinal flora, thereby fundamentally inhibiting the morbidity of the hand-foot-and-mouth disease; the chrysanthemum is used as a messenger medicine in the composition provided by the invention, and as a channel-inducing medicine in the messenger medicine, the chrysanthemum can draw various medicinal materials and introduce the medicinal materials into the disease parts of a human body, so that the composition directly acts on the disease source to improve the curative effect of the composition.

In some embodiments of the present invention, the traditional Chinese medicine composition for treating hand-foot-and-mouth disease comprises, by weight, 14 parts of corydalis tuber, 15 parts of coptis chinensis, 22 parts of licorice root tip, 15 parts of radix rehmanniae, 8 parts of scutellaria baicalensis, 8 parts of bamboo leaves, 10 parts of bistort rhizome, 8 parts of Chinese ilex leaves, 6 parts of mint, 6 parts of burdock, 6 parts of akebia stem, 10 parts of fructus forsythiae, 11 parts of honeysuckle flower and 8 parts of chrysanthemum flower. The proportioning scheme is a preferred proportioning scheme of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, and the composition prepared by the proportioning scheme has stronger medicine property, shorter treatment course and less irritation to a human body.

In a second aspect, the embodiment of the application also provides application of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease in preparation of oral liquid, buccal tablets and decoction for treating the hand-foot-and-mouth disease.

In some embodiments of the present invention, the power of the ultrasonic oscillation is 90-110W, the time of the ultrasonic oscillation is 100-120min, and the temperature of the ultrasonic oscillation is 35-55 ℃. This ultrasonic oscillation's power interval, time interval and temperature interval can make the glycyrrhizic acid molecule dissolve in the ammonia more fast, and can not make other impurity sneak into to guarantee the purity of the glycyrrhizic acid molecule of extracting, if be less than above-mentioned interval, can lead to the glycyrrhizic acid molecule can't be fully extracted from the licorice tip in, if be higher than above-mentioned interval, then can lead to some other impurity and glycyrrhizic acid molecule to dissolve in ammonia water or ethanol together.

In some embodiments of the invention, the volume ratio of ethanol to ammonia is (10-12): 1. The proportion interval can ensure that the ethanol can fully reflux the glycyrrhizic acid molecules in the ammonia water, thereby ensuring that the content of the glycyrrhizic acid molecules in the prepared composition is sufficient.

In some embodiments of the present invention, the ethanol is 30-50% by volume, and the ammonia is 0.5-10% by volume. The volume fraction of ammonia water and ethanol can make glycyrrhizic acid molecules fully dissolved.

In some embodiments of the invention, the pH of the lye is from 8 to 10. The pH range can make glycyrrhizic acid molecules fully dissolved in ammonia water, so that the finally prepared composition contains abundant glycyrrhizic acid molecules to ensure the curative effect of the composition.

In some embodiments of the present invention, the temperature of the above decoction is 80-90 ℃ and the time of the decoction is 2-4 h. The decocting temperature interval and time interval can ensure that beneficial components in the raw materials are fully extracted, and simultaneously, less impurities are separated out; below this temperature and time interval, a lower content of the extracted beneficial component results, and above this temperature and time interval, an excessive amount of impurities is extracted with the beneficial component into the decoction.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth diseases, which comprises the following raw materials of 10g of rhizoma corydalis, 10g of coptis chinensis, 14g of licorice root tip, 10g of radix rehmanniae, 6g of scutellaria baicalensis, 4g of bamboo leaves, 8g of bistort rhizome, 4g of Chinese ilex leaves, 2g of mint, 2g of great burdock achene, 2g of akebia stem, 5g of fructus forsythiae, 7g of honeysuckle and 3g of chrysanthemum.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 0.5% ammonia water and adjusting the pH value to 8 to obtain an alkali liquor, and adding 30% ethanol with the volume being equal to 10 times of that of the ammonia water into the alkali liquor while carrying out ultrasonic oscillation (the ultrasonic power is 90W, the oscillation time is 100min, and the oscillation temperature is 35 ℃) to carry out reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, folium Bambusae, rhizoma Bistortae, folium Ilicis Purpureae, herba Menthae, fructus Arctii, caulis Akebiae, fructus forsythiae, flos Lonicerae and flos Chrysanthemi, decocting at 80 deg.C for 2 hr, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Example 2

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth diseases, which comprises 18g of rhizoma corydalis, 20g of coptis chinensis, 30g of licorice root tip, 20g of radix rehmanniae, 10g of scutellaria baicalensis, 12g of bamboo leaves, 12g of bistort rhizome, 12g of Chinese ilex leaves, 10g of mint, 10g of great burdock achene, 10g of akebia stem, 15g of fructus forsythiae, 15g of honeysuckle and 11g of chrysanthemum.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 10% ammonia water, adjusting the pH value to 10 to obtain an alkali liquor, and adding 50% ethanol with the volume being 12 times that of the ammonia water into the alkali liquor while carrying out ultrasonic oscillation (the ultrasonic power is 110W, the oscillation time is 120min, and the oscillation temperature is 55 ℃) to carry out reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, folium Bambusae, rhizoma Bistortae, folium Ilicis Purpureae, herba Menthae, fructus Arctii, caulis Akebiae, fructus forsythiae, flos Lonicerae and flos Chrysanthemi, decocting at 90 deg.C for 4 hr, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Example 3

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth diseases, which comprises 14g of rhizoma corydalis, 15g of coptis chinensis, 22g of licorice root tip, 15g of radix rehmanniae, 8g of scutellaria baicalensis, 8g of bamboo leaves, 10g of bistort rhizome, 8g of Chinese ilex leaves, 6g of mint, 6g of great burdock achene, 6g of akebia stem, 10g of fructus forsythiae, 11g of honeysuckle and 8g of chrysanthemum.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 5% ammonia water, adjusting the pH value to 9 to obtain an alkali liquor, and adding 30% ethanol with the volume being 11 times that of the ammonia water into the alkali liquor while carrying out ultrasonic oscillation (the ultrasonic power is 100W, the oscillation time is 110min, and the oscillation temperature is 45 ℃) to carry out reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, folium Bambusae, rhizoma Bistortae, folium Ilicis Purpureae, herba Menthae, fructus Arctii, caulis Akebiae, fructus forsythiae, flos Lonicerae and flos Chrysanthemi, decocting at 85 deg.C for 3 hr, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Example 4

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth diseases, which comprises the following raw materials of 12g of rhizoma corydalis, 13g of coptis chinensis, 21g of licorice root tip, 14g of radix rehmanniae, 7g of scutellaria baicalensis, 7g of bamboo leaves, 9g of bistort rhizome, 7g of Chinese ilex leaves, 5g of mint, 5g of great burdock achene, 5g of akebia stem, 9g of fructus forsythiae, 10g of honeysuckle and 7g of chrysanthemum.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 3% ammonia water, adjusting the pH value to 8.6 to obtain an alkali liquor, and adding 27% ethanol with the volume equivalent to 10.6 times of that of the ammonia water into the alkali liquor while performing ultrasonic oscillation (the ultrasonic power is 98W, the oscillation time is 108min, and the oscillation temperature is 43 ℃) to perform reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, folium Bambusae, rhizoma Bistortae, folium Ilicis Purpureae, herba Menthae, fructus Arctii, caulis Akebiae, fructus forsythiae, flos Lonicerae and flos Chrysanthemi, decocting at 82 deg.C for 2.6h, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Example 5

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth diseases, which comprises 15g of rhizoma corydalis, 16g of coptis chinensis, 23g of licorice root tip, 16g of radix rehmanniae, 9g of scutellaria baicalensis, 9g of bamboo leaves, 11g of bistort rhizome, 9g of Chinese ilex leaves, 7g of mint, 7g of great burdock achene, 7g of akebia stem, 11g of fructus forsythiae, 12g of honeysuckle and 9g of chrysanthemum.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 8% ammonia water, adjusting the pH value to 9.3 to obtain an alkali liquor, and adding 38% ethanol with the volume being 11.5 times that of the ammonia water into the alkali liquor while performing ultrasonic oscillation (the ultrasonic power is 106W, the oscillation time is 113min, and the oscillation temperature is 48 ℃) to perform reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, folium Bambusae, rhizoma Bistortae, folium Ilicis Purpureae, herba Menthae, fructus Arctii, caulis Akebiae, fructus forsythiae, flos Lonicerae and flos Chrysanthemi, decocting at 87 deg.C for 3.5h, filtering to obtain decoction, decocting, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Example 6

The embodiment provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, which comprises the following raw materials of 16g of corydalis tuber, 17g of coptis chinensis, 24g of licorice root tip, 13g of radix rehmanniae, 6g of scutellaria baicalensis and 6g of bamboo leaves.

The embodiment also provides a preparation method of the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease, which comprises the following steps of grinding and sieving licorice roots to obtain fine powder, soaking the fine powder in 6.7% ammonia water, adjusting the pH value to 8.8 to obtain an alkali liquor, and adding 29% ethanol with the volume being equal to 10.2 times of that of the ammonia water into the alkali liquor while carrying out ultrasonic oscillation (the ultrasonic power is 91W, the oscillation time is 101min, and the oscillation temperature is 47 ℃) to carry out reflux extraction to obtain an extracting solution; mixing Coptidis rhizoma, rhizoma corydalis, radix rehmanniae, Scutellariae radix, and folium Bambusae, decocting at 89 deg.C for 2.2h, filtering to obtain decoction, and concentrating to obtain concentrated solution; mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

Test examples

Selecting 20 patients with hand-foot-and-mouth disease, and averagely dividing the patients into a group A and a group B, wherein the group A patients are treated by using common aciclovir on the market, and the group B patients are treated by using the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease prepared in the embodiment 3 of the invention, and the using method comprises the following steps: the preparation is administered three times a day, 5ml each time for 10 days.

The results of measuring the temperature of the patient at normal time every 10 days, observing the patient's herpes disappearance and asking the patient for pain, and recording the time at which the temperature returns to normal, the herpes disappearance and the pain disappearance, boxed charts were obtained as shown in fig. 1, fig. 2 and fig. 3, fig. 1 is a boxed chart showing the time at which the temperature of the patient returns to normal, fig. 2 is a boxed chart showing the time at which the herpes subsides, and fig. 3 is a boxed chart showing the time at which the pain subsides.

As shown in the results of figures 1-3, the traditional Chinese medicine composition for treating hand-foot-and-mouth disease prepared by the invention has obvious statistical differences from acyclovir in the normal time of body temperature recovery (. about.. p < 0.05), the time of herpes regression (. about.. p < 0.05) and the time of pain feeling regression (. about.. p < 0.05), so that the traditional Chinese medicine composition for treating hand-foot-and-mouth disease prepared by the invention has obvious inhibition effect on hand-foot-and-mouth disease.

In summary, the embodiment of the present invention provides a traditional Chinese medicine composition for treating hand-foot-and-mouth disease, a preparation method and an application thereof, and the preparation method mainly comprises at least the following beneficial effects:

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating hand-foot-and-mouth disease is characterized by comprising, by weight, 10-18 parts of corydalis tuber, 10-20 parts of coptis chinensis, 14-30 parts of licorice root tip, 10-20 parts of radix rehmanniae, 6-10 parts of scutellaria baicalensis and 4-12 parts of bamboo leaves.

2. The traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 1, further comprising an auxiliary material, wherein the auxiliary material comprises, by weight, 8-12 parts of bistort rhizome, 4-12 parts of Chinese ilex leaf, 2-10 parts of mint, 2-10 parts of great burdock achene, 2-10 parts of akebia stem, 5-15 parts of weeping forsythia capsule, 7-15 parts of honeysuckle flower and 3-11 parts of chrysanthemum.

3. The traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 2, which comprises, by weight, 14 parts of corydalis tuber, 15 parts of coptis chinensis, 22 parts of licorice root tip, 15 parts of radix rehmanniae, 8 parts of scutellaria baicalensis, 8 parts of bamboo leaves, 10 parts of bistort rhizome, 8 parts of Chinese ilex leaves, 6 parts of mint, 6 parts of burdock, 6 parts of akebia stem, 10 parts of fructus forsythiae, 11 parts of honeysuckle flower and 8 parts of chrysanthemum.

4. Use of the Chinese medicinal composition for treating hand-foot-and-mouth disease according to any one of claims 1-3 in the preparation of oral liquid, buccal tablets and decoction for treating hand-foot-and-mouth disease.

5. A method for preparing the Chinese medicinal composition for treating hand-foot-and-mouth disease according to any one of claims 1 to 3, comprising the steps of grinding and sieving the licorice root tips to obtain fine powder, soaking the fine powder in ammonia water and adjusting the pH to obtain alkali liquor, and adding ethanol into the alkali liquor while performing ultrasonic oscillation for reflux extraction to obtain an extract;

decocting the coptis chinensis, the corydalis tuber, the radix rehmanniae, the scutellaria baicalensis and the bamboo leaves, filtering to obtain a decoction, and concentrating the decoction to obtain a concentrated solution;

and mixing the concentrated solution and the extracting solution, and drying to obtain the traditional Chinese medicine composition for treating the hand-foot-and-mouth disease.

6. The method for preparing a Chinese medicinal composition for treating hand-foot-and-mouth disease as claimed in claim 5, wherein the power of the ultrasonic oscillation is 90-110W, the time of the ultrasonic oscillation is 100-120min, and the temperature of the ultrasonic oscillation is 35-55 ℃.

7. The preparation method of the traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 5, wherein the volume ratio of ethanol to ammonia water is (10-12): 1.

8. The preparation method of the traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 7, wherein the volume fraction of ethanol is 30-50%, and the volume fraction of ammonia water is 0.5-10%.

9. The preparation method of the traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 5, wherein the pH of the alkaline solution is 8-10.

10. The preparation method of the traditional Chinese medicine composition for treating hand-foot-and-mouth disease according to claim 5, wherein the decoction temperature is 80-90 ℃, and the decoction time is 2-4 h.