CN105663649A - Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof Download PDF

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CN105663649A
CN105663649A CN201610031010.0A CN201610031010A CN105663649A CN 105663649 A CN105663649 A CN 105663649A CN 201610031010 A CN201610031010 A CN 201610031010A CN 105663649 A CN105663649 A CN 105663649A
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pharyngitis
chinese medicine
root
japanese honeysuckle
medicine composition
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张军龙
张启文
马少平
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NINGXIA GOLD SUN PHARMACEUTICAL CO Ltd
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NINGXIA GOLD SUN PHARMACEUTICAL CO Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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Abstract

The invention provides a traditional Chinese medicine composition for treating pharyngitis and a preparation method thereof. The composition is prepared from ophiopogon roots, honeysuckle flowers, honeysuckle stems, belamcanda roots, scutellaria roots, asparagus roots, akebia stems, platycodon roots and licorice. The preparation method comprises the following steps: eight medicinal materials are mixed and crushed into meal; ethanol is added into the meal with stirring for backflow, herb residues are filtered, rotary condensation is carried out for a filtrate, an extract is obtained by alcohol extraction, and the extract and the herb residues are standby; licorice is crushed for standby; water is added into the herb residues and licorice with stirring, reflux extraction and filtration are carried out, and two kinds of extracts are mixed. The traditional Chinese medicine composition has substantial effects for treating pharyngitis.

Description

A kind of Chinese medicine composition and its preparation method treating pharyngitis
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically refer to it is a kind of Chinese medicine composition and its preparation method for the treatment of pharyngitis.
Background technology
Pharyngitis is under pharyngeal mucosa, mucous membrane and the diffusivity inflammation of Lymphoid tissue. According to the length of the course of disease and the difference of pathological change character, it is divided into acute pharyngitis and the big class of chronic pharyngitis two.
Acute pharyngitis, belongs to " acute inflammation of the throat " category in motherland's medical science. How because of the evil poison invasion and attack throat of wind-heat, internal injury, in lung, is fought mutually and is not gone, and causes swelling throat plug and numbness pain, or heat symptoms caused by an exopathgen Yong Sheng, defends in biography by lung, and heat evil is followed through burning throat, makes swelling and pain in the throat and larynx numbness. This disease is had sore throat, pharyngeal portion flare, and at the bottom of larynx or have particle projection, larynx core swelling is not obvious, and whole body has wind-heat symptom to be the pharyngeal acute inflammation of main clinical manifestation. Chronic pharyngitis is under pharyngeal mucous membrane, mucous membrane and the chronic inflammatory diseases of Lymphoid tissue. With dry throat, pain of itching is uncomfortable, and pharyngeal foreign body sensation or the few phlegm of dry cough are feature. Chronic pharyngitis belongs to the traditional Chinese medical science " larynx numbness " category, comprises " fire of deficiency type larynx numbness ", " deficiency of yang larynx numbness ", " curtain pearl larynx numbness " etc. Etiology and pathogenesis is that internal organs are deficient, and consumption impairment of yin is divided, hyperactivity of deficient fire in throat, or because of acute pharyngitis due to wind-heat recurrent exerbation, remaining heresy be detained, or dust, foul smell stimulate, hobby tobacco and wine are pungent, and internal lesion caused by overexertion is excessive etc. causes. Often it is divided into lung yin virtual loss, deficiency of kidney-YIN, phlegm fire pent-up, the card types such as deficiency of spleen-YANG and kidneyYANG.
The treatment of pharyngitis can adopt western medical treatment and Chinese traditional treatment, but western medical treatment is main and many toxic side effects mainly with microbiotic, and easy resistance, and this disease of traditional Chinese medical herbal treatment, have good effect, the feature that side effect is little. For many years, treat pharyngitis with oral medicinal herb outer treating method (decoction, electuary, spraying gun lozenge) to achieve and be relatively satisfied with effect.
But at present it is also desirable to have one is to treatment acute pharyngitis and the more efficiently Chinese medicine of chronic pharyngitis.
Summary of the invention
It is an object of the invention to provide the Chinese medicine composition of a kind of effective treatment pharyngitis, the pharmacological property of comprehensive multiple medicinal material, make that this Chinese medicine composition plays Yin-nourishing and body fluid promoting, moistening lung clears away heart-fire, have antibechic, open up a kind of medicine that pharyngitis is had good prophylactic-therapeutic effect.
It is a further object of the present invention to provide the preparation method of the Chinese medicine composition of this treatment pharyngitis.
It is an object of the invention to realize in the following manner:
Treating a Chinese medicine composition for pharyngitis, said composition is made up of the raw material of following weight part:
The tuber of dwarf lilyturf 50-60 part, Japanese Honeysuckle 6-8 part, Japanese Honeysuckle Stem 6-8 part, blackberry lily 5-7 part, root of large-flowered skullcap 5-7 part, asparagus fern 4-6 part, akebi 5-7 part, balloonflower root 3-5 part, Radix Glycyrrhizae 3-5 part.
The preferred following weight part of above-mentioned raw materials:
The tuber of dwarf lilyturf 50 parts, Japanese Honeysuckle 6 parts, Japanese Honeysuckle Stem 6 parts, blackberry lily 5 parts, the root of large-flowered skullcap 5 parts, asparagus fern 5 parts, akebi 5 parts, balloonflower root 4 parts, 4 parts, Radix Glycyrrhizae.
Various formulation made by the auxiliary material of above-mentioned composition and pharmaceutical acceptable. Described formulation is decoction, powder, tablet, capsule, granule or pill.
Now the pharmacology of the Chinese medicinal materials of above-mentioned use is analyzed, has further understanding with effect of the Chinese medicine composition of the treatment pharyngitis it formed:
The tuber of dwarf lilyturf: be the dried root of the liliaceous plant tuber of dwarf lilyturf (Ophiopogonjaponicus (L.f) KerGawl.), be conventional enriching yin Chinese medicine, beginning to be loaded in " Shennong Bencaojing ", the successive dynasties, important book on Chinese herbal medicine all had record. Main component have ruscogenin, soap glycosides C, the tuber of dwarf lilyturf steroidal saponin, methyl flavanone tuber of dwarf lilyturf A, methyl flavanone tuber of dwarf lilyturf B, the methyl flavone A tuber of dwarf lilyturf, methyl flavones tuber of dwarf lilyturf B etc. Its taste hardship sweet, micro-, cold nature, the thoughts of returning home, lung, stomach warp, have effect that nourishing Yin and promoting production of body fluid, moistening lung clear away heart-fire, can be used for the treatment illness such as consumption of body fluid caused by febrile disease, restlessness and thirst, the tradition traditional Chinese medical science is mainly used to and the relevant illness such as lung, stomach, insufficiency of heart-YIN or the hot impariment of the lung, stomach, the heart-yin. Modern pharmacology Effect study finds, the tuber of dwarf lilyturf anti-inflammation, hypoxia tolerance, enhancing myocardial contraction, opposing heart disorder, anticancer, antitumor and hypoglycemic etc. in have significant physiological and pharmacological active. Play an important role in treatment acute and chronic pharyngitis.
Japanese Honeysuckle: the flower that the dry flower of caprifoliaceae plant honeysuckle or band are just opened, at the beginning of the summer, the flowers are in blossom put before gather. Main component has biflavone, chlorogenic acid, Reseda odorata glycosides, polysaccharide, phantol and Geraniol. Have clearing heat and detoxicating, dispelling wind and heat pathogens, broad-spectrum antimicrobial, anti-inflammation, antiviral and antipyretic, anti-oxidant. Effect of hepatic cholagogic, hemostasis, reducing blood-fat, alleviation allergy, plays certain effect in treatment pharyngitis.
Blackberry lily: be the dry rhizome of irides blackberry lily. Just germinateed at the beginning of spring or autumn Mo stem leaf withered time excavate, remove fibrous root and silt, drying. Major ingredient has irigenin, irisflorentin, Tectorigenin, wogonin, sandlwood Qin Su, Rhamnetin, mangiferin, coarse wool ambrosin, blackberry lily ketone etc. This product has clearing heat and detoxicating, lung heat clearing away, sputum eliminating, profit pharynx, detumescence, anti-inflammation, antiviral, antibacterial, elimination free radical, antitumor effect, plays certain booster action treating in acute and chronic pharyngitis.
The root of large-flowered skullcap: be the dry root of the labiate root of large-flowered skullcap. Season in spring and autumn two excavates, and removes fibrous root and silt, hits tertia, dry after solarization. Main component has baicalin, scutellarin, wogonin, Wogonoside, Salvia japonica Thunb. element, skullcapflavone I, skullcapflavone II, isocarthamidin etc. There are the effects such as heat-clearing and damp-drying drug, eliminating fire and detoxication, hemostasis, antiabortive, antibacterial, antipyretic, analgesia, antitumor, antiviral, scavenging free radicals, anti-oxidant, protection cardiovascular and cerebrovascular.
Akebi: be the dry rattan stem of plants of Lardizabalaceae akebi, three leaf akebis or Caulis Akebiae. Main component has calceolarioside B, lignan glycosides, hederagenin, oleanolic acid saponin unit etc. Autumn gathers, and intercepts stem, removes thin branch, dry in the shade. There is inducing diuresis for treating stranguria syndrome, the purging intense heat that clears away heart-fire, lactogenesis of stimulating the menstrual flow, relieving inflammation and relaxing pain, antibacterial, antitumor, rheumatism effect.
Asparagus fern: be the dried root of liliaceous plant asparagus fern. Season autumn and winter two excavates, and cleans, and removes stem base and fibrous root, puts and boil in boiling water or steam to the saturating heart, remove crust while hot, cleans, dry.Main component has Radix Asparagi polysaccharide, different smilacin etc. It has nourishing YIN to relieve dryness, control lung yin virtual loss, deficiency of stomach-Yin, calmness, moistening lung are promoted the production of body fluid, cough-relieving, eliminate the phlegm, effect of anti-inflammation, anti-ageing, anticancer, anti-proliferate, play a role in treatment pharyngitis.
Balloonflower root: be the dry root of Campanulaceae balloonflower root. Season in spring and autumn two excavates, and cleans, and removes fibrous root, takes advantage of and fresh peel off crust or do not remove crust, dry. Main component has Platycodin D, apigenin, luteolin, Douglas fir element, Quercetin etc. Can declare in treatment pharyngitis that lung, profit swallows, eliminated the phlegm, apocenosis, immunomodulatory, antitumor, guarantor liver, analgesia etc.
Japanese Honeysuckle Stem: be the dry stem branch of caprifoliaceae plant honeysuckle. Season autumn and winter two taps, and dries. Main component has chlorogenic acid, isochlorogenic acid, meliatin and sweroside, luteolin etc. There is clearing heat and detoxicating, to dredge wind and removing obstruction in channels, inflammation antiviral, anti-antipyretic, antitumor, to improve immunity function effect.
Radix Glycyrrhizae: be the dry root welding technology of glycyrrhizic legume, glycyrrhiza inflate bat or glycyrrhiza glabra. Season in spring and autumn two excavates, and removes fibrous root, dries. Main component has liquirtin, isoliquiritigenin, isoliquiritin, Liquiritigenin, licorice polysaccharide and Potenlini, glabridin etc. For invigorating the spleen and benefiting qi, clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, anti-inflammation, antiulcer agent, spasmolysis.
The preparation method of the Chinese medicine composition that the present invention treats pharyngitis comprises the following steps:
(1) tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root eight kinds of medicinal materials are mixed in proportion, pulverize into particle diameter 40 order meal;
(2) meal is added the doubly heavy mass percent of 6-10 be 80% ethanol stirring and refluxing extract 1-3 time, each 1-2 hour, phegma leaves standstill more than 12 hours, and 300 orders filter the dregs of a decoction, the alcohol-extracted extract of filtrate spin concentration to 60 DEG C condition lower density 1.15～1.25; Medicinal extract and the dregs of a decoction are separately for subsequent use;
(3) pulverize: extracting Radix Glycyrrhizae pulverizes into particle diameter 40 order, for subsequent use;
(4) the water stirring and refluxing that the Radix Glycyrrhizae got in the dregs of a decoction and step (3) that step (2) obtains adds 8-10 times amount is extracted 2-3 time, each 1-2 hour, phegma leaves standstill more than 12 hours, 300 orders filter, and the medicinal extract that filtrate decompression concentrates relative density 1.15～1.25 to 60 DEG C of conditions is for subsequent use.
(5) medicinal extract that medicinal extract step (4) obtained obtains with step (2) mixes and get final product.
The present invention obtains dregs of a decoction water extraction together with Radix Glycyrrhizae of eight kinds of medicinal materials through alcohol extracting, and medicinal material is farthest utilized. Chinese medicine composition of the present invention application in the medicine of preparation treatment pharyngitis has significant effect.
Below by way of test example, significant parameter is described:
One, abstract methods is preferred
1.1 employing orthogonal experimental design screening abstract methods
Now investigate solvent times amount, extraction time, extraction time three factors to the impact extracted. According to the step of embodiment 1, take the 150g tuber of dwarf lilyturf, Japanese Honeysuckle 18g, Japanese Honeysuckle Stem 18g, blackberry lily 15g, root of large-flowered skullcap 15g, asparagus fern 15g, akebi 15g, the alcohol extracting dregs of a decoction of balloonflower root 12g and Radix Glycyrrhizae 12g. Extracting by following level of factor table, level of factor table is in table 1.
The quadrature factor water-glass of table 1. abstract methods
The present invention selects polysaccharide content (%) and dry cream amount (g) to be inspection target, and orthogonal test is carried out data analysis. Orthogonal arrangement table and the results are shown in Table 2.
Orthogonal arrangement that table 2. polysaccharide content (%) and dry cream amount (g) are inspection target and result table
Table provides 9 testing programs.If No. 6 test is A2B3C1, i.e. the water refluxing extraction 2h of 8 times amount, extracts 1 time, and the rest may be inferred. )
Taking dry cream amount as index, range analysis result is A > B > C. Best of breed between each factor and level is A2B3C2, taking C item as error term, carry out variance analysis further, the results are shown in Table 3.
Table 3. is taking dry cream amount as the analysis of variance table of index
(F0.05 (2,2)=19.00) taking dry cream amount as index, each factor on experimental result there are no significant impact, it is preferable that optimised process be A2B3C2。
Take polysaccharide content as index, range analysis result A > C > B. Best of breed between each factor and level is A2B2C3, taking D item as error term, carry out variance analysis further, the results are shown in Table 4.
Table 4. take polysaccharide content as the analysis of variance table of index
(F0.05 (2,2)=19.00) taking polysaccharide content as index, experimental result is had a significant impact by solvent times amount, it is preferable that optimised process be A2B2C3。
For the more orthogonal result of rational evaluation, finding optimum extraction process, two evaluation indexes are carried out comprehensive grading, method of calculation are as follows: in two indices, choosing the highest person respectively as 100 points, all the other press formulae discovery: score Y=weight × (100-maximum+yi), to two indices weight coefficient respectively for being 0.6 and 0.4. By intuitive analysis, taking comprehensive grading as index, show that extraction Influence on test result order is A > B > C by each factor, the best of breed between each factor and level is A2B3C2, taking D item as error term, carry out variance analysis the results of analysis of variance further in table 5.
Table 5. comprehensive grading is the analysis of variance table of index
(F0.05 (2,2)=19.00), taking comprehensive grading be each factor of index to experimental result not statistically significant, extraction process is combined as A2B3C2。
1.2 water extraction proof tests
For verifying above-mentioned experimental result, get the above-mentioned medicinal material of 0.1 times of recipe quantity, according to A2B3C2Condition is extracted, and result is such as table 6
Table 6 water extraction confirmatory experiment result
Test number Dry cream amount (g) Polysaccharide content (%)
1 78.99 4.99%
2 80.32 5.23%
3 79.89 5.12%
The result of proof test is consistent substantially with orthogonal parameter, so the extraction conditions of extraction process by water is amount of water is 8 times amount, extracts twice, each 2h.
Below by way of the test of pesticide effectiveness, the present composition is carried out effect checking:
Pharyngitis is taking inflammation, coughs as the locality disease of feature, closely related with external environment and self food habits. This disease is mainly in grownup, and children also can occur, seriously affects quality of life and the work of patient. Pharyngitis is divided into chronic pharyngitis and acute pharyngitis at present, and the recurrent exerbation of acute pharyngitis causes the generation of chronic pharyngitis. Processing condition of the present invention are through repeated screening, sum up the Empirical formula of application, and experimentation on animals also shows this disease is achieved good therapeutic action. The rabbit blank of chronic pharyngitis illness has obvious therapeutic action through the obtained pharyngitis mouth-sucking tablet of these processing condition having. It is reported as follows:
The feed composition side of tearing open of the present invention is carried out pharyngitis Experiment on therapy by us, compares effect of each prescription further, and 4 prescriptions are respectively:
Prescription 1: of the present invention group (alcohol-extracted extract+the water extracted immersing paste): the tuber of dwarf lilyturf 150g, Japanese Honeysuckle 18g, Japanese Honeysuckle Stem 18g, blackberry lily 15g, root of large-flowered skullcap 15g, asparagus fern 15g, akebi 15g, balloonflower root 12g, eight kinds of medicinal materials mix in proportion, pulverize into meal, times weight percentage that adds 10 by meal is the extraction using alcohol twice of 80%, each 2h obtains the alcohol extracting dregs of a decoction, phegma leaves standstill more than 12 hours, Aspirate supernatant, filter, filtrate is revolved and is steamed for alcohol-extracted extract, the dregs of a decoction add Radix Glycyrrhizae 12g, the water of the times amount that adds 8, extract twice, each 2h, obtain the water extracted immersing paste, the water extracted immersing paste+alcohol-extracted extract is prescription 1.
Prescription 2: Flos Lonicerae extractum group (alcohol extracting+water extraction): Japanese Honeysuckle 18g, pulverize into meal, meal is added 10 times amount 80% ethanol, extract twice, each 2h, after concentrated, obtain alcohol-extracted extract, the water of times amount that the alcohol extracting dregs of a decoction add 8, extracting twice, each 2h obtains the water extracted immersing paste, and the water extracted immersing paste+alcohol-extracted extract is prescription 3.
Prescription 3: Japanese Honeysuckle Stem (alcohol extracting+water extraction): Japanese Honeysuckle Stem 18g pulverizes into meal, meal is added 10 times amount 80% ethanol, extract twice, each 2h, obtaining alcohol-extracted extract after concentrated, the water of times amount that the alcohol extracting dregs of a decoction add 8, extracts twice, each 2h obtains the water extracted immersing paste, and alcohol-extracted extract+the water extracted immersing paste is prescription 4.
Prescription 4: the root of large-flowered skullcap (alcohol extracting+water extraction); Root of large-flowered skullcap 15g pulverizes into meal, times amount 80% ethanol that adds 10 by meal, extracts twice, each 2h, after concentrated alcohol-extracted extract, the water of times amount that the alcohol extracting dregs of a decoction add 8, extracts twice, and each 2h obtains the water extracted immersing paste, and the water extracted immersing paste+alcohol-extracted extract is prescription 5.
1. laboratory animal: rabbit, body weight 2.0～2.5kg China Medicine University Experimental Animal Center.
2. reagent: strong aqua, Tianjin Ke Miou chemical reagent company limited lot number: 140514
Turps, Tianjin Bo Di Chemical Co., Ltd. lot number: 140728
Jinsang Liyan capsule, Forest of Steles in Xi'an medicine company limited-liability company lot number: 141201
3. instrument
Throat spray, almond device entry needle, medical frontal mirror, electronic anus temperature table, baby's scale, self-control rabbit opener, spatula.
4. method and result
4.1 method
Select children rabbit in age 48, random point 6 groups, the ammoniacal liquor that concentration is 2.5% is loaded in throat spray to 48 rabbit spray pharynxs, each 1 time of every day at upper and lower noon, every time spray 3 times, continuous spraying 16d, wherein start administration in modeling the 7th day each administration group, under turps being injected in the pharyngeal mucous membrane of rabbit at the 8th day with tonsilla entry needle, every animal 0.5mL, observes the pharyngeal mucous membrane form of animal, color and luster and secretory product situation every day. Each prescription all gives the given the test agent of 0.2g/kg, and blank group gives same volume solvent, and positive controls gives 0.2g/kg profit pharynx capsule.
4.2 result
4.2.1 general state was from modeling the 3rd day, and major part rabbit engenders oral area of scratching, frequently drinking-water and measure few, oral secretion increases, and food of receiving reduces, spontaneous activity minimizing, and pharyngeal congestion is the symptom such as garnet, micro-swelling. After positive controls, prescription 1, prescription 2, prescription 3 treat 10d, above-mentioned symptom and sign recovers normal substantially.
4.2.2 body weight and Temperature changing the results are shown in Table 7,8;
Table 7 rabbit body weight change table (kg,N=8)
Compare with blank groupeP < 0.05bP < 0.01, compares with prescription 1cP < 0.05.
From in table 7, prescription 1 compares with each prescription and all has significant effect.
Table 8 rabbit body temperature change list (DEG C,N=8)
Compare with blank groupeP < 0.05,bP < 0.01, compares with prescription 1cP < 0.05.
From in table 8, prescription 1 compares with each prescription and all has significant effect.
Embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
Prescription: the tuber of dwarf lilyturf 100g, Japanese Honeysuckle 12g, Japanese Honeysuckle Stem 12g, blackberry lily 10g, root of large-flowered skullcap 10g, asparagus fern 10g, akebi 10g, balloonflower root 8g, Radix Glycyrrhizae 8g.
Preparation method:
(1) pulverize: the tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root eight kinds of medicinal materials are mixed in proportion, pulverizes into meal, for subsequent use.
(2) alcohol extracting: get the meal that (1) is obtained, times amount 80% ethanol stirring and refluxing extracts twice to add 8, each 2 hours, and phegma leaves standstill more than 12 hours, Aspirate supernatant, filters, and filtrate is revolved and steamed to obtain alcohol-extracted extract, obtains the dregs of a decoction for subsequent use.
(3) pulverize: the Radix Glycyrrhizae getting in ratio is pulverized, for subsequent use.
(4) water extraction: the water stirring and refluxing of times amount that the Radix Glycyrrhizae got in proportion in the dregs of a decoction and (3) that (2) obtain adds 10 is extracted twice, each 2 hours, phegma leaves standstill more than 12 hours, Aspirate supernatant, filter, filtrate decompression concentrates to the clear cream of relative density 1.15～1.25 (60 DEG C) for subsequent use, and recording water extraction dry spun is 29.31%, and polysaccharide content is 4.99%.
(5) the medicinal extract mixing oven dry that clear cream and step (2) obtain is obtained dry cream and get final product.
Embodiment 2
Prescription: the tuber of dwarf lilyturf 100g, Japanese Honeysuckle 16g, Japanese Honeysuckle Stem 16g, blackberry lily 14g, root of large-flowered skullcap 14g, asparagus fern 8g, akebi 14g, balloonflower root 10g, Radix Glycyrrhizae 10g.
Preparation method:
(1) pulverize: the tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root eight kinds of medicinal materials are mixed in proportion, pulverizes into meal, for subsequent use.
(2) alcohol extracting: get the meal that (1) is obtained, times amount 80% ethanol stirring and refluxing extracts twice to add 8, each 2 hours, and phegma leaves standstill more than 12 hours, Aspirate supernatant, filters, and filtrate is revolved and steamed to obtain alcohol-extracted extract, obtains the dregs of a decoction for subsequent use.
(3) pulverize: the Radix Glycyrrhizae getting in ratio is pulverized, for subsequent use.
(4) water extraction: the water stirring and refluxing of times amount that the Radix Glycyrrhizae got in proportion in the dregs of a decoction and (3) that (2) obtain adds 6 is extracted twice, each 1 hour, phegma leaves standstill more than 12 hours, Aspirate supernatant, filter, filtrate decompression concentrates to the clear cream of relative density 1.15～1.25 (60 DEG C) for subsequent use, and water extraction dry spun is 29.02%, and polysaccharide content is 4.82%.
(5) the medicinal extract mixing oven dry that clear cream and step (2) obtain is obtained dry cream and get final product.
Embodiment 3
Prescription: the tuber of dwarf lilyturf 120g, Japanese Honeysuckle 14g, Japanese Honeysuckle Stem 14g, blackberry lily 12g, root of large-flowered skullcap 12g, asparagus fern 12g, akebi 10g, balloonflower root 6g, Radix Glycyrrhizae 6g.
Preparation method:
(1) pulverize: the tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root eight kinds of medicinal materials are mixed in proportion, pulverizes into meal, for subsequent use.
(2) alcohol extracting: getting the meal that (1) is obtained, times amount 80% ethanol stirring and refluxing extracts 3 times to add 10, each 2 hours, phegma leaves standstill more than 12 hours, Aspirate supernatant, filters, and filtrate is revolved and steamed to obtain alcohol-extracted extract, obtains the dregs of a decoction for subsequent use.
(3) pulverize: the Radix Glycyrrhizae getting in ratio is pulverized, for subsequent use.
(4) water extraction: the water stirring and refluxing of times amount that the Radix Glycyrrhizae got in proportion in the dregs of a decoction and (3) that (2) obtain adds 8 is extracted twice, each 1.5 hours, phegma leaves standstill more than 12 hours, Aspirate supernatant, filter, filtrate decompression concentrates to the clear cream of relative density 1.15～1.25 (60 DEG C) for subsequent use, and recording water extraction dry spun is 26.76%, and polysaccharide content is 4.33%.
(5) the medicinal extract mixing oven dry that clear cream and step (2) obtain is obtained dry cream and get final product.
Embodiment 4
Add after the dried cream powder prepared according to embodiment 1 method is broken the auxiliary materials such as starch conveniently technique prepare granule.
Embodiment 5
Add after the dried cream powder prepared according to embodiment 1 method is broken the auxiliary materials such as starch conveniently technique prepare particle, the more obtained tablet of compressing tablet.
Embodiment 6
Add after the dried cream powder prepared according to embodiment 1 method is broken the auxiliary materials such as starch conveniently technique prepare particle, the more obtained capsule of filling gelatine capsule skin.
Embodiment 7
Add after the dried cream powder prepared according to embodiment 1 method is broken auxiliary material conveniently technique prepare honeyed bolus.
Embodiment 8
Add after the dried cream powder prepared according to embodiment 1 method is broken auxiliary material conveniently technique prepare drip a ball.

Claims (8)

1. treat the Chinese medicine composition of pharyngitis for one kind, it is characterised in that, said composition is made up of following raw material:
The tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root and Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of pharyngitis according to claim 1, it is characterised in that, the weight part of described raw material is:
The tuber of dwarf lilyturf 50-60 part, Japanese Honeysuckle 6-8 part, Japanese Honeysuckle Stem 6-8 part, blackberry lily 5-7 part, root of large-flowered skullcap 5-7 part, asparagus fern 4-6 part, akebi 5-7 part, balloonflower root 3-5 part, Radix Glycyrrhizae 3-5 part.
3. the Chinese medicine composition for the treatment of pharyngitis according to claim 1 and 2, it is characterised in that, the weight part of described raw material is:
The tuber of dwarf lilyturf 50 parts, Japanese Honeysuckle 6 parts, Japanese Honeysuckle Stem 6 parts, blackberry lily 5 parts, the root of large-flowered skullcap 5 parts, asparagus fern 5 parts, akebi 5 parts, balloonflower root 4 parts, 4 parts, Radix Glycyrrhizae.
4. the preparation method of the Chinese medicine composition for the treatment of pharyngitis described in claim 1 or 2, it is characterised in that, the method comprises the following steps:
(1) tuber of dwarf lilyturf, Japanese Honeysuckle, Japanese Honeysuckle Stem, blackberry lily, the root of large-flowered skullcap, asparagus fern, akebi, balloonflower root eight kinds of medicinal materials are mixed in proportion, pulverize into particle diameter 40 order meal;
(2) meal is added the doubly heavy mass percent of 6-10 be 80% ethanol stirring and refluxing extract 1-3 time, each 1-2 hour, phegma leaves standstill more than 12 hours, and 300 orders filter the dregs of a decoction, and under filtrate spin concentration to 60 DEG C condition, relative density is the alcohol-extracted extract of 1.15～1.25; Medicinal extract and the dregs of a decoction are separately for subsequent use;
(3) extracting Radix Glycyrrhizae pulverizes into particle diameter 40 order, for subsequent use;
(4) dregs of a decoction that step (2) obtains are got and the Radix Glycyrrhizae that step (3) obtains adds water, refluxing extraction 2-3 time, each 1-2 hour, phegma left standstill more than 12 hours, 300 orders filter, and filtrate decompression concentrates to the medicinal extract of 60 DEG C of condition lower densities 1.15～1.25 for subsequent use.
(5) medicinal extract that medicinal extract step (4) obtained obtains with step (2) mixes and get final product.
5. preparation method according to claim 4, it is characterised in that, in step (2), it is the ethanol of 80% that meal adds the doubly heavy mass percent of 6-10.
6. preparation method according to claim 4, it is characterised in that, in step (4), get the dregs of a decoction that step (2) obtains and the Radix Glycyrrhizae that step (3) obtains adds the water of 8-10 times amount.
7. the Chinese medicine composition of the treatment pharyngitis that prepared by preparation method according to claim 4, it is characterised in that, said composition can be made into various formulation: decoction, powder, tablet, capsule, granule, pill.
8. Chinese medicine composition according to claim 1 treats the application in the medicine of pharyngitis in preparation.
CN201610031010.0A 2016-01-19 2016-01-19 Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof Pending CN105663649A (en)

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CN106957813A (en) * 2017-05-11 2017-07-18 湖南赛诺生物科技股份有限公司 A kind of porcine islet resuscitation fluid and method for resuscitation
CN115645490A (en) * 2022-12-12 2023-01-31 元和药业股份有限公司 Tablet for pharyngitis and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN106957813A (en) * 2017-05-11 2017-07-18 湖南赛诺生物科技股份有限公司 A kind of porcine islet resuscitation fluid and method for resuscitation
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Application publication date: 20160615