CN105106578A - Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses tradition Chinese medicine composition for treating diabetic nephropathy and a preparation method of the traditional Chinese medicine composition and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from raw materials as follows: mulberry leaves, astragalus membranaceus, common anemarrhena rhizome, szechuan lovage rhizome, fructus Lycii, rhizoma coptidis, dahurian angelica root, flos sophorae, danshen roots and liquorice. The traditional Chinese medicine composition is reasonable, has a good synergistic effect, is compatibly used as a medicine for treating diabetic nephropathy and has a very remarkable effect according to clinical verification.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of diabetic nephropathy and preparation method thereof.
Background technology
Diabetic nephropathy is one of common complication of diabetes, and be one of diabetes generalized capillary pathological changes performance, Clinical symptoms is gradual renal function injury, hypertension,, there is severe renal nonfunction late period in edema, is one of major causes of death of diabetics.In recent years along with China's population average life span extends, Diet lifestyle, the change of structure, the prevalence linearly ascendant trend of diabetes, and due to the improvement of Therapeutic Method, the increase of life span, diabetic nephropathy and other complication also increase.
Diabetic nephropathy, in Chinese medicine document, both belonged to diabetes, belonged to again the edema in nephropathy category, turbid urine, distension, in the diseases such as obstruction and rejection, pathogenesis is then to suffer from a deficiency of the kidney, initial stage is precise and tiny leaks, for a long time then disturbance in functioning of QI, retention of water-damp in the body, very then accumulate in turbid poison, visceral-qi void declines, and easily change card, total disease belonging to deficiency in origin and excess in superficiality.The long-term diabetes continued, make glomerule loose, cause glomerule fibrosis, atrophy and renal arteriosclerosis, the direct result brought is that kidney parenchymal ischemi and nephron constantly reduce, and develops into chronic kidney hypofunction.Before not forming chronic kidney hypofunction, the treatment way of doctor trained in Western medicine and the traditional Chinese medical science is all control blood glucose, alleviates glomerule burden.But once form chronic renal failure, doctor trained in Western medicine and the traditional Chinese medical science all do not have good way, finally can only dialyse and kidney transplantation, not only risk is high, expense expenditure is large and patient is very painful.
Chinese patent application 201410436459.6 discloses a kind of Chinese medicine composition for the treatment of diabetic nephropathy, and this Chinese medicine composition is obtained by following raw material: Radix Astragali 10-50 part, Caulis Spatholobi 10-50 part, Radix Rehmanniae Preparata 10-50 part, Rhizoma Dioscoreae 5-20 part, Fructus Corni 5-20 part, Semen Euryales 5-30 part, Fructus Rosae Laevigatae 5-20 part, Hirudo (processed) 1-5 part, Radix Et Rhizoma Rhei 2-15 part, Herba Potentillae Discoloris 5-30 part, Poria 10-50 part, Semen Plantaginis 10-50 part.This Chinese medicine composition has the albuminuretic excretion of minimizing, and extend effect of the tempo of diabetic nephropathy, but this Chinese medicine composition is at blood sugar lowering, kidney and spleen invigorating aspect effect is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of diabetic nephropathy, and effect that this pharmaceutical composition has blood sugar lowering, guarantor's kidney protects kidney and spleen invigorating is invigorated blood circulation, also has good effect, the advantages such as cure rate is high, taking convenience.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
In order to solve this technical problem, the technical solution used in the present invention is:
Treat a Chinese medicine composition for diabetic nephropathy, be prepared from by the raw material of following parts by weight: Folium Mori 15-30 part, Radix Astragali 15-30 part, Rhizoma Anemarrhenae 14-20 part, Rhizoma Chuanxiong 16-20 part, Fructus Lycii 10-14 part, Rhizoma Coptidis 13-19 part, Radix Angelicae Dahuricae 15-20 part, Flos Sophorae 6-10 part, Radix Salviae Miltiorrhizae 10-14 part and Radix Glycyrrhizae 5-15 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 15 parts, Folium Mori, the Radix Astragali 15 parts, the Rhizoma Anemarrhenae 14 parts, Rhizoma Chuanxiong 16 parts, Fructus Lycii 10 parts, Rhizoma Coptidis 13 parts, the Radix Angelicae Dahuricae 15 parts, 6 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 10 parts and 5 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 30 parts, Folium Mori, the Radix Astragali 30 parts, the Rhizoma Anemarrhenae 20 parts, Rhizoma Chuanxiong 20 parts, Fructus Lycii 14 parts, Rhizoma Coptidis 19 parts, the Radix Angelicae Dahuricae 20 parts, 10 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 14 parts and 15 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 28 parts, Folium Mori, the Radix Astragali 25 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Chuanxiong 17 parts, Fructus Lycii 12 parts, Rhizoma Coptidis 16 parts, the Radix Angelicae Dahuricae 18 parts, 8 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 13 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made into capsule, tablet, powder, granule, oral liquid or pill.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
(1): get Folium Mori, wash away impurity, 50 DEG C of hot air dryings 5 hours, control moisture is 3-8%, pulverizes, and crosses 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves, for subsequent use;
(2): get the Radix Astragali, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Sophorae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae, clean, crushed after being dried, add the water soaking 0.5-1 hour of coarse powder total amount 8-13 times amount, then decoct 2-3 time, each 1-2 hour, filter, merging filtrate, filtrate is at 50-65 DEG C, vacuum is survey the clear paste that relative density is 1.10-1.20 under vacuum-concentrcted to 60 DEG C condition under the condition of 0.05-0.08MPa, cooling, slowly adds ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter, obtain filtrate A and filtering residue;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): merge described filtrate A, liquor B and cleaning mixture, survey the thick paste that relative density is 1.10-1.20, drying under reduced pressure under mixing final vacuum is evaporated to 60 DEG C of conditions, pulverize, cross 100-200 mesh sieve, mix with described Ultra-fine Powder of Mulberry Leaves, to obtain final product.
Source, the nature and flavor of the present invention's component used, return through and effect:
Folium Mori: this product is be the dried leaves of moraceae plants Mulberry; Bitter in the mouth, sweet, cold nature; Return lung, Liver Channel; Wind and heat dispersing, clearing away lung-heat to relieve cough, liver heat removing and eyesight improving.
The Radix Astragali: this product is the root of the leguminous plant Radix Astragali; Sweet in the mouth, tepor; Return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.
The Rhizoma Anemarrhenae: this product is plant drying root stock; Hardship, cold; Enter lung, stomach, kidney channel; Nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Fructus Lycii: this product is the dry fruit of plant Fructus Lycii, sweet, flat; Nourishing the liver, nourishing kidney, lung moistening.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae; Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping.
Flos Sophorae: Flos Sophorae refers to the dry flower and alabastrum of leguminous plant Chinese scholartree, bitter in the mouth, cold nature return liver, large intestine channel; Enter blood to hold back and fall, body slightly falls apart; There is cooling blood for hemostasis, effect of purging liver-fire; Cure mainly hemorrhoidal hamorrhage just.
Radix Salviae Miltiorrhizae: the dry root welding technology that this product is labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, is slightly cold; GUIXIN, Liver Channel; Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, each Chinese medicinal components of Chinese medicine composition of the present invention is collaborative, and in blood sugar lowering, effect is better;
2, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and toxic and side effects is little;
3, Chinese medicine composition of the present invention has and protects kidney and protect the effect that kidney and spleen invigorating invigorate blood circulation, and also has good effect, the advantages such as cost is low, and obvious effective rate is high, taking convenience.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
Raw material is taken: 15 parts, Folium Mori, the Radix Astragali 15 parts, the Rhizoma Anemarrhenae 14 parts, Rhizoma Chuanxiong 16 parts, Fructus Lycii 10 parts, Rhizoma Coptidis 13 parts, the Radix Angelicae Dahuricae 15 parts, 6 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 10 parts and 5 parts, Radix Glycyrrhizae by following parts by weight.
Preparation method is as follows:
(1): get Folium Mori, wash away impurity, 50 DEG C of hot air dryings 5 hours, controlling moisture is 5%, pulverizes, and crosses 40 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves, for subsequent use;
(2): get the Radix Astragali, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Sophorae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae, clean, crushed after being dried, add the water soaking 1 hour of coarse powder total amount 8 times amount, then decoct 2 times, each 2 hours, filter, merging filtrate, filtrate is at 50 DEG C, vacuum is survey the clear paste that relative density is 1.10 under vacuum-concentrcted to 60 DEG C condition under the condition of 0.05MPa, cooling, slowly adds ethanol while stirring to alcohol content for reaching 60%, and 4 DEG C leave standstill 24 hours, filter, obtain filtrate A and filtering residue;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4 times amount volume fraction is the ethanol of 60%, 4 DEG C leave standstill 3 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 60% again, collects and merges cleaning mixture;
(4): merge described filtrate A, liquor B and cleaning mixture, survey the thick paste that relative density is 1.10, drying under reduced pressure under mixing final vacuum is evaporated to 60 DEG C of conditions, pulverize, cross 100 mesh sieves, mix with described Ultra-fine Powder of Mulberry Leaves, to obtain final product.
Add starch, 5% gelatin solution and distilled water, be pressed into thin slice, be ground into granule, obtain the granule of pharmaceutical composition.
embodiment 2:
Raw material is taken: 30 parts, Folium Mori, the Radix Astragali 30 parts, the Rhizoma Anemarrhenae 20 parts, Rhizoma Chuanxiong 20 parts, Fructus Lycii 14 parts, Rhizoma Coptidis 19 parts, the Radix Angelicae Dahuricae 20 parts, 10 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 14 parts and 15 parts, Radix Glycyrrhizae by following parts by weight.
Preparation method:
(1): get Folium Mori, wash away impurity, 50 DEG C of hot air dryings 5 hours, controlling moisture is 8%, pulverizes, and crosses 60 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves, for subsequent use;
(2): get the Radix Astragali, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Sophorae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae, clean, crushed after being dried, add the water soaking 0.5 hour of coarse powder total amount 13 times amount, then decoct 3 times, each 1 hour, filter, merging filtrate, filtrate is at 65 DEG C, vacuum is survey the clear paste that relative density is 1.20 under vacuum-concentrcted to 60 DEG C condition under the condition of 0.08MPa, cooling, slowly adds ethanol while stirring to alcohol content for reaching 60%, and 4 DEG C leave standstill 12 hours, filter, obtain filtrate A and filtering residue;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 6 times amount volume fraction is the ethanol of 40%, 4 DEG C leave standstill 5 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2 times of 60% again, collects and merges cleaning mixture;
(4): merge described filtrate A, liquor B and cleaning mixture, survey the thick paste that relative density is 1.20, drying under reduced pressure under mixing final vacuum is evaporated to 60 DEG C of conditions, pulverize, cross 200 mesh sieves, mix with described Ultra-fine Powder of Mulberry Leaves, to obtain final product.
Add starch, lactose, 20% gelatin solution, dried starch and distilled water, add lubricant after combination drying, tabletting, coating, obtain the tablet of pharmaceutical composition.
embodiment 3:
Raw material is taken: 28 parts, Folium Mori, the Radix Astragali 25 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Chuanxiong 17 parts, Fructus Lycii 12 parts, Rhizoma Coptidis 16 parts, the Radix Angelicae Dahuricae 18 parts, 8 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 13 parts and 10 parts, Radix Glycyrrhizae by following parts by weight.
Preparation method:
(1): get Folium Mori, wash away impurity, 50 DEG C of hot air dryings 5 hours, controlling moisture is 5%, pulverizes, and crosses 50 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves, for subsequent use;
(2): get the Radix Astragali, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Sophorae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae, clean, crushed after being dried, add the water soaking 0.5 hour of coarse powder total amount 10 times amount, then decoct 2 times, each 2 hours, filter, merging filtrate, filtrate is at 60 DEG C, vacuum is survey the clear paste that relative density is 1.20 under vacuum-concentrcted to 60 DEG C condition under the condition of 0.06MPa, cooling, slowly adds ethanol while stirring to alcohol content for reaching 50%, and 4 DEG C leave standstill 24 hours, filter, obtain filtrate A and filtering residue;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 5 times amount volume fraction is the ethanol of 50%, 4 DEG C leave standstill 4 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 50% again, collects and merges cleaning mixture;
(4): merge described filtrate A, liquor B and cleaning mixture, survey the thick paste that relative density is 1.20, drying under reduced pressure under mixing final vacuum is evaporated to 60 DEG C of conditions, pulverize, cross 200 mesh sieves, mix with described Ultra-fine Powder of Mulberry Leaves, to obtain final product.
Add starch, lactose, 5% gelatin solution, dried starch and distilled water, mixing, dry, pulverize into fine powder, incapsulates in shell, obtain the capsule of pharmaceutical composition.
clinical trial
1, physical data: this organizes 120 routine diabetic nephropathy clinical volunteers patients, wherein man 60 example, female 60 example, 40-79 year, 59.5 years old mean age.
2, grouping and Therapeutic Method
By 120 routine diabetic nephropathy patient, be divided into 2 groups at random, often organize 60 people, concrete grouping is as follows with administration:
Chinese medicine composition group: capsule (0.3g*100 grain/bottle) prepared by the administration embodiment of the present invention 3, every day 2 times, each 4, serve on 2 months;
Matched group: take metformin hydrochloride tablet (smart Heihe pharmaceutcal corporation, Ltd of Harbin Pharmaceutical Group three, accurate word H20064095, the 0.25g*50 grain/bottle of traditional Chinese medicines), one time 2,3 times on the one, serve on 2 months.
3, evaluation of clinical curative effect standard
Efficacy on diabetic nephropathy judges:
Effective: clinical symptoms is improved obviously, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. disappear or substantially disappear, blood sugar level fluctuation is within normal range, blood pressure≤128/80mmHg, 24h urine protein < 30mg, blood urea nitrogen and creatinine are all down to normal level;
Effective: clinical symptom relief, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. be improved significantly, fasting glucose controls desirable, and fluctuation of blood pressure is at about 140/90mmHg, 24h urine protein and blood urea nitrogen creatinine all have decline, but do not take a turn for the better completely;
Invalid: clinical symptoms is improved not obvious, blood pressure and blood glucose decline without decline or have but undesirable, and 24h urine protein quantitation and blood urea nitrogen creatinine all do not decline, or decline and do not reach effective standard.
4, therapeutic outcome, as shown in table 1.
Table 1 therapeutic outcome
5, conclusion
Clinical treatment for diabetic nephropathy is investigated and is found, the therapeutic effect of Chinese medicine composition of the present invention is remarkable, its obvious effective rate and total effective rate are all far above existing medicine, visible, diabetic nephropathy Be very effective treated by the Chinese medicine composition of the present invention capsule that particularly prepared by embodiment 3, can be used as the drug use for the treatment of diabetic nephropathy.
Claims (6)
1. treat the Chinese medicine composition of diabetic nephropathy for one kind, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Folium Mori 15-30 part, Radix Astragali 15-30 part, Rhizoma Anemarrhenae 14-20 part, Rhizoma Chuanxiong 16-20 part, Fructus Lycii 10-14 part, Rhizoma Coptidis 13-19 part, Radix Angelicae Dahuricae 15-20 part, Flos Sophorae 6-10 part, Radix Salviae Miltiorrhizae 10-14 part and Radix Glycyrrhizae 5-15 part.
2. the Chinese medicine composition for the treatment of diabetic nephropathy as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 15 parts, Folium Mori, the Radix Astragali 15 parts, the Rhizoma Anemarrhenae 14 parts, Rhizoma Chuanxiong 16 parts, Fructus Lycii 10 parts, Rhizoma Coptidis 13 parts, the Radix Angelicae Dahuricae 15 parts, 6 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 10 parts and 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of diabetic nephropathy as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 30 parts, Folium Mori, the Radix Astragali 30 parts, the Rhizoma Anemarrhenae 20 parts, Rhizoma Chuanxiong 20 parts, Fructus Lycii 14 parts, Rhizoma Coptidis 19 parts, the Radix Angelicae Dahuricae 20 parts, 10 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 14 parts and 15 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of diabetic nephropathy as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 28 parts, Folium Mori, the Radix Astragali 25 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Chuanxiong 17 parts, Fructus Lycii 12 parts, Rhizoma Coptidis 16 parts, the Radix Angelicae Dahuricae 18 parts, 8 parts, Flos Sophorae, Radix Salviae Miltiorrhizae 13 parts and 10 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment diabetic nephropathy as described in any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into capsule, tablet, powder, granule, oral liquid or pill.
6. a preparation method for the Chinese medicine composition of the treatment diabetic nephropathy as described in any one of claim 1-4, is characterized in that, the preparation method of described Chinese medicine composition comprises following step:
(1): get Folium Mori, wash away impurity, 50 DEG C of hot air dryings 5 hours, control moisture is 3-8%, pulverizes, and crosses 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves, for subsequent use;
(2): get the Radix Astragali, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Sophorae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae, clean, crushed after being dried, add the water soaking 0.5-1 hour of coarse powder total amount 8-13 times amount, then decoct 2-3 time, each 1-2 hour, filter, merging filtrate, filtrate is at 50-65 DEG C, vacuum is survey the clear paste that relative density is 1.10-1.20 under vacuum-concentrcted to 60 DEG C condition under the condition of 0.05-0.08MPa, cooling, slowly adds ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter, obtain filtrate A and filtering residue;
(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): merge described filtrate A, liquor B and cleaning mixture, survey the thick paste that relative density is 1.10-1.20, drying under reduced pressure under mixing final vacuum is evaporated to 60 DEG C of conditions, pulverize, cross 100-200 mesh sieve, mix with described Ultra-fine Powder of Mulberry Leaves, to obtain final product.
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| CN201610320891.8A CN105796847A (en) | 2015-10-10 | 2015-10-10 | Method for preparing traditional Chinese medicinal composition for treating diabetic nephropathy |
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| CN106552088A (en) * | 2017-01-18 | 2017-04-05 | 南京中医药大学 | Chinese medicine composition effective site with treatment diabetic nephropathy and its preparation method and application |
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| CN101366908A (en) * | 2008-08-11 | 2009-02-18 | 李丽 | Traditional Chinese medicine for treating diabetes |
| CN104147316A (en) * | 2014-05-21 | 2014-11-19 | 北京中医药大学东直门医院 | Traditional Chinese medicinal composition for treating diabetic nephrophthy |
| CN104940531A (en) * | 2015-07-27 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of Chinese herbal composition to preparation of medicine for treating diabetic nephropathy |
| CN104940596A (en) * | 2015-07-27 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
| CN104958536A (en) * | 2015-07-29 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
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| CN102247515B (en) * | 2010-05-17 | 2012-10-17 | 天津药物研究院 | Traditional Chinese medicine compound preparation used for treating diabetic nephropathy, and preparation method thereof |
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2015
- 2015-10-10 CN CN201610320891.8A patent/CN105796847A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366908A (en) * | 2008-08-11 | 2009-02-18 | 李丽 | Traditional Chinese medicine for treating diabetes |
| CN104147316A (en) * | 2014-05-21 | 2014-11-19 | 北京中医药大学东直门医院 | Traditional Chinese medicinal composition for treating diabetic nephrophthy |
| CN104940531A (en) * | 2015-07-27 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of Chinese herbal composition to preparation of medicine for treating diabetic nephropathy |
| CN104940596A (en) * | 2015-07-27 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof |
| CN104958536A (en) * | 2015-07-29 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106552088A (en) * | 2017-01-18 | 2017-04-05 | 南京中医药大学 | Chinese medicine composition effective site with treatment diabetic nephropathy and its preparation method and application |
| CN106552088B (en) * | 2017-01-18 | 2019-10-01 | 南京中医药大学 | Chinese medicine composition active component and its preparation method and application with treatment diabetic nephropathy |
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Application publication date: 20151202 |
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| WW01 | Invention patent application withdrawn after publication |