CN104940531A - Application of Chinese herbal composition to preparation of medicine for treating diabetic nephropathy - Google Patents
Application of Chinese herbal composition to preparation of medicine for treating diabetic nephropathy Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to application of a Chinese herbal composition to preparation of medicine for treating diabetic nephropathy. The Chinese herbal composition is prepared from the following raw materials: cistanche deserticola, moringa leaves, astragalus, salvia miltiorrhiza, angelica, red paeony roots, dogwood, burdock, eucommia, yam, Chinese wolfberry fruits, epimedium, fleece-flower roots, cinnamomum cassia and liquorice. The Chinese herbal composition has the advantages that the medicine composition is reasonable; the synergistic effect is high; the Chinese herbal composition is taken as compatible medicine for treating diabetic nephropathy; clinical tests proof that the effect is very remarkable.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy.
Background technology
Diabetic nephropathy is the maximum a kind of chronic complicating diseases of serious and hazardness that diabetes cause, it is one of diabetes generalized capillary pathological changes performance, Clinical symptoms is albuminuria, gradual renal function injury, hypertension,, there is severe renal nonfunction late period in edema, is one of major causes of death of diabetics.Current western medical treatment is many sets about from aspects such as diet control, strengthening glycemic control, blood pressure lowering, adjustment lipid metabolism, or adopts the treatment meanss such as dialysis, renal transplantation, although effectively, but bring heavy financial burden to patient, Chinese traditional treatment has rich experience, successful, do not need Long-term taking medicine, no dependence, overall dialectical, individuality treats, promote pancreatic cell regeneration ability, human internal organ is in harmonious proportion, equilibrium between yin and yang, recover benign cycle, obtain good therapeutic effect.Treatment by Chinese herbs also has price low in addition, has no side effect, not easily the advantage such as recurrence.
Leaf of Moringa refers to the leaves of the perennial tropical deciduous tree Moringa tree (being also called drumstick tree) originating in India, and be a kind of high calcium plant product, calcium content is more than 4 times of milk, in addition, also containing the very high trace element such as potassium, ferrum, zinc.The tender leaf of Moringa of the selected children of leaf of Moringa powder, forms through micronizing, has comprehensive extra-nutrition, improves immunity, eliminating toxin and beautifying the skin, and logical intestinal is convenient, the effects such as fat-reducing.Leaf of Moringa powder is nutritious and comprehensive, and vitamin E is 70 times and 40 times of spirulina and analysis for soybean powder respectively.Moringa has " miracle tree ", the title of " mother's ace buddy " and " medical treasure case ".In Africa, it is called as the cattle milk of the poor; In India, Moringa has had the edible history of more than one thousand years, has become one of indispensable food of daily life; Be called in China Taiwan " 21 century human body bodyguard ".
Chinese invention patent 201210311984.6 discloses a kind of Chinese medicine composition being used for the treatment of diabetic nephropathy, and this Chinese medicine composition is obtained by following raw material: Radix Astragali 2-10 part, dried lily bulb 2-10 part, Semen Persicae 1-6 part, Hirudo 1-6 part, Radix Et Rhizoma Rhei 1-4 part, Rhizoma Alismatis 2-6 part, Fructus Rosae Laevigatae 2-6 part, Semen Euryales 2-6 part, Radix Achyranthis Bidentatae 2-6 part, Cortex Eucommiae 2-6 part.This Chinese medicine composition has supplementing QI and nourishing YIN, clearing heat and expelling damp, effect of promoting blood circulation to remove obstruction in the collateral, but this Chinese medicine composition is at blood sugar lowering, and kidney and spleen invigorating aspect effect is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, this Chinese medicine composition has blood sugar lowering, protects effect that kidney protects kidney and benefiting QI for activating blood circulation, also there is good effect, the advantages such as side effect is low, taking convenience.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
In order to solve this technical problem, inventor has invented a kind of brand-new Chinese medicine composition and its preparation technology, perfectly solves above-mentioned technical problem.
Chinese medicine composition of the present invention comprises the raw materials of following parts by weight: Herba Cistanches 5-30 part, leaf of Moringa 5-20 part, Radix Astragali 6-30 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Radix Paeoniae Rubra 6-12 part, Fructus Corni 6-12 part, Fructus Arctii 6-15 part, Cortex Eucommiae 6-9 part, Rhizoma Dioscoreae 3-20 part, Fructus Lycii 6-12 part, Herba Epimedii 3-9 part, Radix Polygoni Multiflori 6-12 part, Cortex Cinnamomi 1-5 part and Radix Glycyrrhizae 1-15 part.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 5 parts, leaf of Moringa 5 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 6 parts, Fructus Corni 6 parts, Fructus Arctii 6 parts, the Cortex Eucommiae 6 parts, Rhizoma Dioscoreae 3 parts, Fructus Lycii 6 parts, Herba Epimedii 3 parts, Radix Polygoni Multiflori 6 parts, Cortex Cinnamomi 1 part and 1 part, Radix Glycyrrhizae.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 30 parts, leaf of Moringa 20 parts, the Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Fructus Corni 12 parts, Fructus Arctii 15 parts, the Cortex Eucommiae 9 parts, Rhizoma Dioscoreae 20 parts, Fructus Lycii 12 parts, Herba Epimedii 9 parts, Radix Polygoni Multiflori 12 parts, Cortex Cinnamomi 5 parts and 15 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 25 parts, leaf of Moringa 10 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Paeoniae Rubra 9 parts, Fructus Corni 9 parts, Fructus Arctii 10 parts, the Cortex Eucommiae 7 parts, Rhizoma Dioscoreae 12 parts, Fructus Lycii 9 parts, Herba Epimedii 6 parts, Radix Polygoni Multiflori 9 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition can be made into capsule, tablet, powder, granule, oral liquid or pill.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
Take Herba Cistanches, leaf of Moringa, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Corni, Fructus Arctii, the Cortex Eucommiae, Rhizoma Dioscoreae, Fructus Lycii, Herba Epimedii, Radix Polygoni Multiflori, Cortex Cinnamomi and Radix Glycyrrhizae, add 4-8 times amount water soaking 1-3 hour, intense fire decocts boiling 30 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, 2-4 times of water gaging is added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, 100-150 mesh sieve is crossed after pulverizing, obtain Chinese medicine composition.
Source, the nature and flavor of the present invention's component used, return through and effect:
Herba Cistanches: this product is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche; Sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel; Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
The Radix Astragali: this product is the root of the leguminous plant Radix Astragali; Sweet in the mouth, tepor; Return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Fructus Corni: this product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni; Sour in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming.
Fructus Arctii: Compositae Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) is used as medicine with root; Acrid in the mouth, warm in nature; Expelling wind and cold pain relieving.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae; Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae; Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum; Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Herba Epimedii: this product is Berberidaceae plant Herba Epimedii dry aerial parts; Acrid in the mouth, sweet, warm in nature; Return liver, kidney channel; Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb; Bitter in the mouth, sweet, puckery, warm in nature; Return liver, the heart, kidney channel; Removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention have employed leaf of Moringa, and by the synergism of leaf of Moringa and other Chinese medicinal components, in blood sugar lowering, effect is better;
2, compared with the chemotherapeutic agent of Current therapeutic diabetes, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improve the compliance of diabetics, and improve the quality of life of patient.
3, Chinese medicine composition of the present invention has and protects kidney and protect the effect that kidney and spleen invigorating invigorate blood circulation, and also has good effect, the advantages such as cost is low, and obvious effective rate is high, taking convenience.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 pharmaceutical composition comprises the raw materials of following parts by weight: Herba Cistanches 5 parts, leaf of Moringa 5 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 6 parts, Fructus Corni 6 parts, Fructus Arctii 6 parts, the Cortex Eucommiae 6 parts, Rhizoma Dioscoreae 3 parts, Fructus Lycii 6 parts, Herba Epimedii 3 parts, Radix Polygoni Multiflori 6 parts, Cortex Cinnamomi 1 part and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Take Herba Cistanches, leaf of Moringa, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Corni, Fructus Arctii, the Cortex Eucommiae, Rhizoma Dioscoreae, Fructus Lycii, Herba Epimedii, Radix Polygoni Multiflori, Cortex Cinnamomi and Radix Glycyrrhizae, add 4 times amount water soaking 2 hours, intense fire decocts boiling 30 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, 2 times of water gagings are added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20, drying under reduced pressure, 100 mesh sieves are crossed after pulverizing, obtain Chinese medicine composition, add capsule and commonly use adjuvant, incapsulate in shell, obtain the agent of the embodiment of the present invention 1 Chinese medicinal composition capsules.
embodiment 2:
The embodiment of the present invention 2 pharmaceutical composition comprises the raw materials of following parts by weight: Herba Cistanches 30 parts, leaf of Moringa 20 parts, the Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Fructus Corni 12 parts, Fructus Arctii 15 parts, the Cortex Eucommiae 9 parts, Rhizoma Dioscoreae 20 parts, Fructus Lycii 12 parts, Herba Epimedii 9 parts, Radix Polygoni Multiflori 12 parts, Cortex Cinnamomi 5 parts and 15 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3:
The embodiment of the present invention 3 pharmaceutical composition comprises the raw materials of following parts by weight: Herba Cistanches 25 parts, leaf of Moringa 10 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Paeoniae Rubra 9 parts, Fructus Corni 9 parts, Fructus Arctii 10 parts, the Cortex Eucommiae 7 parts, Rhizoma Dioscoreae 12 parts, Fructus Lycii 9 parts, Herba Epimedii 6 parts, Radix Polygoni Multiflori 9 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 4:
The embodiment of the present invention 4 pharmaceutical composition comprises the raw materials of following parts by weight: Herba Cistanches 22 parts, leaf of Moringa 15 parts, the Radix Astragali 23 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 10 parts, Radix Paeoniae Rubra 8 parts, Fructus Corni 9 parts, Fructus Arctii 11 parts, the Cortex Eucommiae 7 parts, Rhizoma Dioscoreae 15 parts, Fructus Lycii 10 parts, Herba Epimedii 4 parts, Radix Polygoni Multiflori 7 parts, Cortex Cinnamomi 4 parts and 9 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 5:
The embodiment of the present invention 5 pharmaceutical composition comprises the raw materials of following parts by weight: Herba Cistanches 28 parts, leaf of Moringa 13 parts, the Radix Astragali 22 parts, Radix Salviae Miltiorrhizae 14 parts, Radix Angelicae Sinensis 9 parts, Radix Paeoniae Rubra 9 parts, Fructus Corni 8 parts, Fructus Arctii 14 parts, the Cortex Eucommiae 7 parts, Rhizoma Dioscoreae 18 parts, Fructus Lycii 9 parts, Herba Epimedii 5 parts, Radix Polygoni Multiflori 11 parts, Cortex Cinnamomi 2 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
chinese medicine composition of the present invention is to the therapeutical effect of Diabetic nephropathy animal model
1 prepares model
Select healthy male adult SD rats 70, body weight 0.35kg-0.4kg, feed with high lipid food, do not limit and take the photograph water.Abdominal cavity is injected with streptozotocin after rat is carried out one-sided kidney ligation operation.Operation consent Rat Fast 12h, injection Nembutal sodium solution is anaesthetized, after confirming anesthesia, by rat along kidney base of a fruit ligation kidney arteriovenous and ureter.When postoperative 2 weeks, each group Rat Fast 18h, then disposable celiac injects 1% streptozotocin solution 0.55g/kg, and concrete administration volume is 5.5ml/kg, and after injection, rat freely ingests water.After modeling completes 72h, survey blood glucose through tail vein blood.Modeling Success criteria: 1. fasting glucose >=16.65mmol/L; 2. glucose in urine strong positive; 3. urine volume is greater than 50% of matched group, and namely model is set up.
2 experiment grouping and administrations
After modeling terminates, 70 rats are divided into 7 groups at random, often organize 10, be respectively model group, pioglitazone group, Chinese medicine A group, Chinese medicine B group, Chinese medicine C group, Chinese medicine D group and Chinese medicine E group.Each group gives following medicine respectively:
Model group: the isopyknic distilled water of gavage;
Pioglitazone group: gavage pioglitazone 0.25g/kgd;
Chinese medicine A group: Chinese medicinal composition capsules agent 0.3 g/kgd prepared by the gavage embodiment of the present invention 1;
Chinese medicine B group: Chinese medicinal composition capsules agent 0.3 g/kgd prepared by the gavage embodiment of the present invention 2;
Chinese medicine C group: Chinese medicinal composition capsules agent 0.3 g/kgd prepared by the gavage embodiment of the present invention 3;
Chinese medicine D group: Chinese medicinal composition capsules agent 0.3 g/kgd prepared by the gavage embodiment of the present invention 4;
Chinese medicine E group: Chinese medicinal composition capsules agent 0.3 g/kgd prepared by the gavage embodiment of the present invention 5;
Above-mentioned each group every day gastric infusion once, continuous 8 weeks, normally raise.Blood sampling measures fasting glucose, glycolated hemoglobin and microdose urine protein.
3 index determinings
(1) mensuration of blood glucose: all rats detect fasting glucose respectively at getting tail vein before administration after 8 weeks with administration, the blood sample of taking-up is put into protein precipitant, after room temperature places 7min, centrifugal 5min(3000r/min), get supernatant, use determination of glucose oxidase blood glucose value.
(2) mensuration of glycolated hemoglobin: each group rat after 8 weeks, measures glycolated hemoglobin by immune gel diffusion method with administration before administration.
(3) mensuration of microalbumin in urinating: administration 8 weeks rear rats are put in metabolic cage respectively and raise, collect 12 hours overnight urine, accurate recording urine volume.Get 4ml, after sodium azide process, centrifugal (2000r/min) 10min, gets supernatant and is placed in-20 DEG C of refrigerators and preserves urinaryalbumin to be measured.The albumin standards 400ml getting respective concentration adds in supernatant, adds 200ml 0.231mmol/L bromophenol blue developer respectively, and mixing (preventing bubble), with ultraviolet spectrophotometer, measures absorbance A under 600nm.
4 experimental results and discussion
Table 1 Chinese medicine composition of the present invention is on the impact of diabetic nephropathy rats fasting glucose
Note: compare with model group, * P < 0.05, * * P < 0.01.
As shown in Table 1, after the administration of Chinese medicine A, B, C, D and E group, the blood glucose value of rat obviously reduces, and compared with model group, has the difference of significance, and wherein, the change of blood sugar value of Chinese medicine C group is maximum; The blood glucose value of pioglitazone group and Chinese medicine A, B, C, D and E group is suitable, but hypoglycemic effect is not so good as the good of Chinese medicine A, B, C, D and E group; Visible, Chinese medicine composition of the present invention obviously can reduce the blood glucose of diabetic nephropathy rats.
Table 2 Chinese medicine composition of the present invention is on the impact of diabetic nephropathy rats glycolated hemoglobin
Note: compare with model group, * P < 0.05, * * P < 0.01.
As shown in Table 2, after the administration of Chinese medicine A, B, C, D and E group, the glycolated hemoglobin of rat obviously reduces, and compared with model group, has the difference of significance, and wherein, Chinese medicine C group, compared with model group, has extremely significant difference; Compared with model control group, the glycolated hemoglobin no difference of science of statistics after the treatment of pioglitazone group; Visible, Chinese medicine composition of the present invention has the effect reducing diabetic nephropathy rats glycolated hemoglobin.
Table 3 Chinese medicine composition of the present invention is on the impact of diabetic nephropathy rats microdose urine protein
Note: compare with model group, * P < 0.05, * * P < 0.01.
As shown in Table 3, compared with model group, the microdose urine protein content of pioglitazone group and Chinese medicine A, B, C, D and E group all has significant difference, and wherein each group of Chinese medicine has pole significant difference; Visible, Chinese medicine composition of the present invention has good synergism in treatment diabetic nephropathy rats microdose urine protein, its therapeutic effect is significantly better than pioglitazone group, and this shows that Chinese medicine composition of the present invention is delaying to have outstanding treatment advantage in diabetic nephropathy PD.
chinese medicine composition of the present invention is to the observation of curative effect of diabetic nephropathy clinical volunteers patient
One, diagnostic criteria
Tcm diagnosis standard: have foam in urine, weak, nausea and vomiting, shallow complexion or dark and gloomy, heavy sensation of the body edema, soreness of the waist and knees and abdominal distention, nocturia, forgetful, insomnia, dizziness and tinnitus, feverish sensation in the palms and soles, purplish tongue or light red tongue or ecchymosis, thick fur is greasy, deep-thready pulse or puckery; Dialectically logical to adjust for weakness of the spleen and kidney, lung lose, the water stasis of blood tied mutually, water turbid regardless of.
Two, evaluation of clinical curative effect standard
Effective: clinical symptoms is improved obviously, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. disappear or substantially disappear, blood sugar level fluctuation is within normal range, blood pressure≤128/80mmHg, 24h urine protein < 30mg, blood urea nitrogen and creatinine are all down to normal level;
Effective: clinical symptom relief, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. be improved significantly, fasting glucose controls desirable, and fluctuation of blood pressure is at about 140/90mmHg, 24h urine protein and blood urea nitrogen creatinine all have decline, but do not take a turn for the better completely;
Invalid: clinical symptoms is improved not obvious, blood pressure and blood glucose decline without decline or have but undesirable, and 24h urine protein quantitation and blood urea nitrogen creatinine all do not decline, or decline and do not reach effective standard.
Three, clinical trial
1 physical data
All selected diabetic nephropathy clinical volunteers patients are divided into 6 groups at random, treatment A group 60 example, wherein male patient 30 example, female patient 30 example; Treatment B group 60 example, wherein male patient 35 example, female patient 25 example; Treatment C group 60 example, wherein male patient 38 example, female patient 22 example; Treatment D group 60 example, wherein male patient 32 example, female patient 28 example; Treatment E group 60 example, wherein male patient 29 example, female patient 31 example; Matched group 60 example, wherein male patient 40 example, female patient 20 example.Age is 40 years old-79 years old, 59.5 years old mean age.6 groups of influence factors such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2 Therapeutic Method
Treatment A group: take the capsule (0.25g*60 grain/bottle) that embodiment 1 prepares, every day 3 times, each 4, serve on 1 month;
Treatment B group: take the capsule (0.25g*60 grain/bottle) that embodiment 2 prepares, every day 3 times, each 4, serve on 1 month;
Treatment C group: take the capsule (0.25g*60 grain/bottle) that embodiment 3 prepares, every day 3 times, each 4, serve on 1 month;
Treatment D group: take the capsule (0.25g*60 grain/bottle) that embodiment 4 prepares, every day 3 times, each 4, serve on 1 month;
Treatment E group: take the capsule (0.25g*60 grain/bottle) that embodiment 5 prepares, every day 3 times, each 4, serve on 1 month;
Matched group: take TANGMAIKANG KELI (Sichuan Sunnyhope Pharmaceutical Co., Ltd., accurate word Z10970026, the 5g*10 bag/box of traditional Chinese medicines), one time 1 bag, 3 times on the one, serve on 1 month.
3 therapeutic outcomes, as shown in table 1.
Table 4 therapeutic effect
This test adopts TANGMAIKANG KELI as a control group, TANGMAIKANG KELI is by the Radix Astragali, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Radix Ophiopogonis, the Chinese medicines such as Rhizoma Polygonati meticulously refine and form, there is replenishing YIN and removing heat, blood circulation promoting and blood stasis dispelling, QI invigorating is reinforced the kidney, hypoglycemic effect, can be used for patient such as treatment non-insulin-dependent diabetes mellitus and complication etc., by comparing with traditional Chinese medicine composition for treating effect of the present invention, embody the curative effect of Chinese medicine composition of the present invention in the sick nephropathy for the treatment of urine, make inventor surprisingly, treatment A group, treatment B group, treatment C group, the obvious effective rate for the treatment of D group and treatment E group is all greater than 80%, total effective rate is all greater than 90%, much larger than obvious effective rate and the total effective rate of matched group, wherein, obvious effective rate and the total effective rate for the treatment of C group are the highest, visible, pharmaceutical composition good effect of the present invention, obvious effective rate is high, can as the drug use for the treatment of diabetic nephropathy.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. Chinese medicine composition is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, it is characterized in that described Chinese medicine composition is obtained by the raw material of following weight portion: Herba Cistanches 5-30 part, leaf of Moringa 5-20 part, Radix Astragali 6-30 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Radix Paeoniae Rubra 6-12 part, Fructus Corni 6-12 part, Fructus Arctii 6-15 part, Cortex Eucommiae 6-9 part, Rhizoma Dioscoreae 3-20 part, Fructus Lycii 6-12 part, Herba Epimedii 3-9 part, Radix Polygoni Multiflori 6-12 part, Cortex Cinnamomi 1-5 part and Radix Glycyrrhizae 1-15 part.
2. a kind of Chinese medicine composition as claimed in claim 1 is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, it is characterized in that described Chinese medicine composition is obtained by the raw material of following weight portion: Herba Cistanches 5 parts, leaf of Moringa 5 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 6 parts, Fructus Corni 6 parts, Fructus Arctii 6 parts, the Cortex Eucommiae 6 parts, Rhizoma Dioscoreae 3 parts, Fructus Lycii 6 parts, Herba Epimedii 3 parts, Radix Polygoni Multiflori 6 parts, Cortex Cinnamomi 1 part and 1 part, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition as claimed in claim 1 is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, it is characterized in that described Chinese medicine composition is obtained by the raw material of following weight portion: Herba Cistanches 30 parts, leaf of Moringa 20 parts, the Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Fructus Corni 12 parts, Fructus Arctii 15 parts, the Cortex Eucommiae 9 parts, Rhizoma Dioscoreae 20 parts, Fructus Lycii 12 parts, Herba Epimedii 9 parts, Radix Polygoni Multiflori 12 parts, Cortex Cinnamomi 5 parts and 15 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine composition as claimed in claim 1 is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, it is characterized in that described Chinese medicine composition is obtained by the raw material of following weight portion: Herba Cistanches 25 parts, leaf of Moringa 10 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 9 parts, Radix Paeoniae Rubra 9 parts, Fructus Corni 9 parts, Fructus Arctii 10 parts, the Cortex Eucommiae 7 parts, Rhizoma Dioscoreae 12 parts, Fructus Lycii 9 parts, Herba Epimedii 6 parts, Radix Polygoni Multiflori 9 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
5. a kind of Chinese medicine composition as described in as arbitrary in claim 1-4, for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, is characterized in that: described Chinese medicine composition can be made into capsule, tablet, powder, granule, oral liquid or pill.
6. a kind of Chinese medicine composition as described in as arbitrary in claim 1-4 is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step: take Herba Cistanches, leaf of Moringa, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Fructus Corni, Fructus Arctii, the Cortex Eucommiae, Rhizoma Dioscoreae, Fructus Lycii, Herba Epimedii, Radix Polygoni Multiflori, Cortex Cinnamomi and Radix Glycyrrhizae, add 4-8 times amount water soaking 1-3 hour, intense fire decocts boiling 30 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, 2-4 times of water gaging is added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, 100-150 mesh sieve is crossed after pulverizing, obtain Chinese medicine composition.
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Cited By (7)
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| CN105106578A (en) * | 2015-10-10 | 2015-12-02 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method of traditional Chinese medicine composition |
| CN105168581A (en) * | 2015-10-10 | 2015-12-23 | 临沂草之美医药科技有限公司 | Application of traditional Chinese medicine composition in preparation of drugs for treating diabetic nephropathies |
| CN105311413A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Traditional Chinese medicinal composition containing folium artemisiae argyi for treating diabetic nephropathy and preparation method of traditional Chinese medicinal composition |
| CN105311470A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy |
| CN105412834A (en) * | 2015-12-21 | 2016-03-23 | 暨南大学 | Application of traditional Chinese medicine composition in preparing medicine for treating CAD (Coronary Artery Disease) |
| CN105833090A (en) * | 2016-05-19 | 2016-08-10 | 武红莲 | Traditional Chinese medicine composition for treating nephrosis of diabetics |
| CN108245606A (en) * | 2018-03-02 | 2018-07-06 | 无锡市第二人民医院 | A kind of golden cicada flower prescription medicine for treating diabetic nephropathy and preparation method thereof |
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| CN105106578A (en) * | 2015-10-10 | 2015-12-02 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method of traditional Chinese medicine composition |
| CN105168581A (en) * | 2015-10-10 | 2015-12-23 | 临沂草之美医药科技有限公司 | Application of traditional Chinese medicine composition in preparation of drugs for treating diabetic nephropathies |
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| CN105311470A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy |
| CN105412834A (en) * | 2015-12-21 | 2016-03-23 | 暨南大学 | Application of traditional Chinese medicine composition in preparing medicine for treating CAD (Coronary Artery Disease) |
| CN105833090A (en) * | 2016-05-19 | 2016-08-10 | 武红莲 | Traditional Chinese medicine composition for treating nephrosis of diabetics |
| CN108245606A (en) * | 2018-03-02 | 2018-07-06 | 无锡市第二人民医院 | A kind of golden cicada flower prescription medicine for treating diabetic nephropathy and preparation method thereof |
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Application publication date: 20150930 |