CN101099844A - Compound for spleen-strengthening and kidney-nourishing preparation and preparing method - Google Patents

Abstract

The invention is concerned with a kind of dispensation of invigorating the spleen and tonifying the kidney preparation and its preparation method. It relates to raw milkvetch root, raw red sage root, Rhizoma Dioscoreae, raw bighead atractylodes rhizome, broomrape, roud cardamon seed, raw rhubarb, raw liquorice, and so on. Dry, grind, soak, boil out, boil out again, mix about materials to get the said preparation. It bases on traditional Chinese medicine theory and the correlation theory of five parenchymatous viscera. This dispensation is fit for chronic kidney disease without anaphylactic response and side effect. It can release many clinical symptoms, such as spontaneous perspiratio and fatigue, short of breath and want of speech, yellowish complexion and emaciation, inappetence and abdominal distension, improve the kidney function and nutriture to prolong survival time of sufferers. It has low cost and easy preparation technology.

Description

The prescription of tonifying speen and tonifying kidney preparation and preparation method

Technical field

The present invention relates to a kind ofly have the protection renal function, delay the renal function aging, improve the preparation of chronic kidney hypofunction patient malnutrition effect, relate to the prescription and the preparation method of this tonifying speen and tonifying kidney preparation specifically.

Background technology

Chronic renal failure (Chronic renal failure, CRF) be to influence one of the commonly encountered diseases of body health of people and frequently-occurring disease, at present existing more than the 100 ten thousand chronic renal failure patients in the whole world need survive by dialysis, and just with the speed increment in every year average 8%.Annual treatment renal disease patient needs huge burden economically, and expensive kidney replacement therapy expense has brought white elephant for family and society, and the treatment measure of therefore exploring delaying chronic kidney depletion causes medical expert's concern and attention day by day.

Modern medicine thinks that chronic kidney hypofunction is to be started by multiple factor, and through multiple factor mediation slowly development form, the startup factor comprises hypertension, hyperlipidemia, albuminuria, immune-mediated, glomerular capillary intravascular coagulation etc.Known at present, hypertension, lipid metabolic disorder, glomerular sclerosis and kidney region fibrosis are the common pathological characters that various former and secondary kidney diseases are developed to end stagerenaldisease, so improve the precipitating factor of hypertension and lipid metabolic disorder, glomerular sclerosis and interstitial fibrosis and carry out active intervention, be the important method that modern medicine delays renal failure.Accumulateing in the excess pathogen such as China's medical circle is agreed at present substantially to the understanding of chronic kidney hypofunction, thinks that its pathology belongs to deficiency in origin and excess in superficiality, and the spleen renal failure loses, and the five internal organs negative and positive of qi and blood deficiency is this, and turbid damp, blood stasis, water are wet is mark, and giving consideration to both the incidental and fundamental, strengthening vital QI to eliminate pathogenic factors are worked as in treatment.Chinese medicine is having its special advantages aspect the control kidney disease; modern pharmacological research has proved that part Chinese medicine can effectively improve patient's blood coagulable status; correct lipid metabolic disorder; improve immune status; and then improve the metabolism status of glomerule; the control renal fibrosis is protected remaining nephron.For the patient who accepts dialysis or renal transplantation, Chinese medicine can also reduce related complication, the quality of making the life better.With respect to the doctor trained in Western medicine controlling blood pressure, regulate disorders of lipid metabolism and methods such as anti-glomerular sclerosis, anti-kidney region fibrosis, Chinese medicine has characteristics such as stable curative effect, relapse rate are low, few side effects.In addition, for the chronic kidney disease patient of need long term maintenance treatment, the letter of Chinese medicine, just, honest and clean advantage not only can make patient's compliance improve, and also alleviated patient's financial burden greatly, improves the sustainability of treatment.

Malnutrition is chronic kidney hypofunction patient's a common complication, and about 40% chronic kidney hypofunction patient has malnutrition in various degree.Malnutrition can cause that the patient immune function is low, anemia and the infection that takes place frequently, and influences quality of life of patient and closely related with mortality rate.The CRF malnutrition is multifactorial result, comprise proteinic distribution, energy metabolism, hormone degraded, infect and merge other disease and because anorexia, feel sick, the infringement of nitrogen matter toxin etc.And in the malnutrition generating process, the effect of lipomodulin and related gene thereof is the focus of studying at present.Lipomodulin is the ob gene outcome, is a kind of a kind of peptide hormone that is produced by the adipose cell that is connected in specific receptor, at first finds in brain, mainly acts on hypothalamic appetite center.The transgenic animal experiment is found, lacks the gene that produces lipomodulin, will cause food absorption minimizing and energy expenditure to increase, thereby induce body weight to lose rapidly.Owing to food absorption reduces the malnutrition that causes is a common clinical problem in patient CRF, and influences prognosis conversely.LouiseNordfors etc. studies show that: the CRF patients serum lipomodulin that carries out and do not carry out dialysis treatment all obviously raises, therefore be considered to a kind of appetite suppressant, by influencing Y neuropeptide (Neuropeptide Y, NPY) and/or melanocortin system and influence appetite, and high-caliber lipomodulin will cause anorexia and malnutrition, and find that glomerular filtration rate is relevant with the serum lipomodulin, promptly cause the lipomodulin level to raise, and the high inductive ob gene expression of lipomodulin mass formed by blood stasis feedback suppression is overcome by inflammatory cytokine by the ob gene expression of plasma clearance that lowers and downward modulation.The endogenous lipomodulin is glomerular filtration, renal tubules metabolic degradation and remove in body rapidly by kidney circulation.And find that recently patient CRF has a very low ob gene expression than healthy person, be negative correlation with serum lipomodulin level, supposition is in the carrying out property CRF patient of high lipomodulin level, and the blood plasma lipomodulin clearance rate of reduction is the part of the centrifugal feedback loop of downward modulation ob gene expression.In addition, fat also is the independently important determiner of decision CRF patients serum's lipomodulin level, and along with the increase of fat, lipomodulin and concentration of insulin also increase.Research also shows that infusion of insulin can stimulate the lipomodulin secretion, prompting: plasma insulin may be a key factor that influences CRF patients serum lipomodulin level, Denis etc. discover that human recombinant insulin-like growth factor-i (rhIGF-1) can reduce CRF dialysis patient serum lipomodulin level, and rhIGF-1 adds that the human recombinant growth hormone then increases serum lipomodulin level.In addition, cytokine also can increase animal lipomodulin mRNA level and anorexia as TNF-a, IL-1 etc., the secretion that body is interior, in vitro study also confirms TNF-a scalable lipomodulin.

Not studies confirm that prevention and correction CRF patient's malnutrition is all particularly important for improving CRF patients ' life quality and prognosis at present although still have clinical randomized prospective, this point has become the common recognition of Most scholars.At present, still lack practicality, effective Therapeutic Method and medicine for patient's CRF malnutrition.Thereby, how to improve CRF patient's nutriture, and seek a kind of economy, effective therapeutic modality or medicine, improve patient's survival rate and quality of life, become the important topic of studying in this field.

Though the effect of Chinese medicine more and more causes people's extensive concern, but the part masses have report still the time because of the individual example using some folk prescriptions among the people, proved recipe and folk prescription and cause renal function injury, the standard that present Chinese medicine research also still exists on diagnosis and the curative effect differs, the scientific research method is tight inadequately, problems such as observe the curative effect is strict inadequately, and preparation is impure.Therefore, be badly in need of filtering out, determined curative effect with strong points to chronic kidney hypofunction, meet industry medication standard, through experiment and the effective prescription of clinical verification.

The content of invention

Purpose of the present invention promptly is at above-mentioned deficiency; based on traditional theory of Chinese medical science; on the basis of the relevant theory of the five internal organs; in conjunction with clinical practice and zoopery; screening also sums up a kind of prescription with renal function protecting effect, and the prescription and the preparation method of this tonifying speen and tonifying kidney preparation is provided specifically.Side's medicine provided by the present invention is applicable to that mainly chronic renal disease (comprising chronic glomerulonephritis, chronic tubal nephritis, chronic renal insufficiency etc.) Chinese medical discrimination belongs to deficiency of spleen-YANG and kidneyYANG and part spleen deficiency of kidney-QI patient, use the present invention not have irritated reaction, have no side effect, obvious reduction of patient fatigue and weakness, the lazyness of breathing hard speech, yellowish complexion is become thin, clinical symptoms such as anorexia abdominal distention, improve patients " renal function and nutriture, reach and improve patient's life quality, prolong patient's purpose of life cycle, the present invention is with low cost, reparation technology is simple and easy to do.

The prescription of tonifying speen and tonifying kidney preparation is characterized in that, the quality proportioning of prescription and each component is as follows:

Radix Astragali 30-35 part is given birth to Radix Salviae Miltiorrhizae 30-35 part Rhizoma dioscoreae 30-35 part

Rhizoma Atractylodis Macrocephalae 20-25 part Herba Cistanches 10-15 part Fructus Amomi Rotundus 10-15 part

Radix Et Rhizoma Rhei 5-10 part Radix Glycyrrhizae 5-10 part

Certainly, in order to obtain better effect, the present invention can preferably fill a prescription and the quality proportioning of each component as follows:

Radix Astragali 30-33 part is given birth to Radix Salviae Miltiorrhizae 30-33 part Rhizoma dioscoreae 30-33 part

Rhizoma Atractylodis Macrocephalae 20-23 part Herba Cistanches 10-13 part Fructus Amomi Rotundus 10-13 part

Radix Et Rhizoma Rhei 5-8 part Radix Glycyrrhizae 5-8 part

Certainly, in order to obtain further good effect, the present invention can preferably fill a prescription and the quality proportioning of each component as follows:

30 parts of 30 parts of Rhizoma dioscoreaes of 30 parts of living Radix Salviae Miltiorrhizaes of Radix Astragali

10 parts of 10 portions of Fructus Amomi Rotunduss of 20 parts of Herba Cistanches of Rhizoma Atractylodis Macrocephalae

5 parts of 5 parts of Radix Glycyrrhizae of Radix Et Rhizoma Rhei

Preparing such formulations comprises the steps:

1), oven dry: various prescriptions are prepared in proportion, under 50～70 ℃ high temperature, dry, the room temperature of drying in the air naturally then;

2), pulverize: various prescriptions are pulverized through pulverizer, crossed 80 molybdenums sieve then, it is standby to become powdery;

3), soak: select sand kettle or enamel pan for use, avoid with iron pan, aluminum pot, put into said components in sand kettle or the enamel pan and add the clear water merceration, 20～30 minutes merceration time, water consumption is controlled at soaked 2～5 centimetres of medicines;

4), decoct: (big fire) fries in shallow oil to boiling with high heat earlier, changes slow fire (little fire) then and fries in shallow oil slowly, and decocting time from boiling timing 40～60 minutes, takes out medicinal liquid then for the first time;

5), secondary decocts: add clear water then in sand kettle or enamel pan, water consumption is controlled at soaked 1～3 centimetre of medicine, utilized slow fire (little fire) to carry out secondary then and decocted, for the second time decocting time, from boiling timing 20～30 minutes, then medicinal liquid is taken out;

6), above-mentioned twice juice of boiling medicine is fully mixed, take at twice then.

When taking, 11 children take and take 50～150 milliliters generally speaking, and the adult takes and takes 200～300 milliliters.

Prescription pharmacology of the present invention explanation

Theoretical foundation of the present invention is, analyzes in conjunction with the Compendium of Material Medica record and the modern Chinese medicine property of medicine of Li Shizhen (1518-1593 A.D.), in above-mentioned prescription:

The Radix Astragali: the Radix Astragali is the dry root of the leguminous plant Radix Astagali or the film English Radix Astragali.Former plant is born in hillside, ditch side or the shrubbery, and happiness is dry, sunlight, and sweet in the mouth is warm in nature.Return lung, spleen channel." nontoxic, by stagnant blood between five Tibetan, it is deficient to mend the husband, five kinds of over strain weakness and emaciation, QI invigorating, Li Yin gas in " Mingyi Bielu " record." " property of medicine opinion " also said can main dyspnea due to deficiency, the renal failure deafness is treated cold and heat.The modern medicine study proof Radix Astragali all has therapeutical effect to nephritis, renal failure, nephrotic syndrome, chronic renal insufficiency, to celebrating big toxin nephrotoxicity antagonism is arranged, and also has diuresis.Pharmacological research confirms: the Radix Astragali injection intravenous injection obviously raises the serum albumin of rat MCN model, and serum cholesterol obviously reduces, and can increase the blood fortune of glomerular capillary, reduces IgG and C3 and deposits in the glomerular mesangium district; Oral administration astragalus can significantly reduce urine protein and diuresis is arranged, and muscle protein is synthetic during nephropathy reduces, and orgotein is synthetic to be increased; The Radix Astragali can promote muscle and liver albumen to synthesize, and makes the plasma protein of nephropathy Mus reach normal range, can be used for various acute and chronic nephritis, the control of nephropathy and renal failure; The Radix Astragali can be removed oxygen-derived free radicals in addition, produces by suppressing transforming growth factor (TGF-β), reduces extracellular matrix (ECM) and generates, and regulates cellular immunization and humoral immunization, reduces urine protein, renal function protecting.The Radix Astragali can also resist the effect of immunosuppressant preparation, and the panimmunity factor is had regulating action preferably.Can also improve the every characteristic of hemorheology, anticoagulant, antithrombotic, hemopoietic function improvement.And the collagen that can increase tissue is synthetic, prolongs cell survival, and antioxidation has anti-aging effects.It is " integration of edible and medicinal herbs " good merchantable brand that integrates dietetic therapy, health preserving, health care, tonification.With in the present invention, get its spleen reinforcing yang invigorating, the effect of benefiting QI for strengthening the superficies.

Radix Et Rhizoma Rhei: Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Former plant is born in grass slope, mountain region or border.Like cold and cool weather, cold-resistant.Bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.The Shennong's Herbal record " main blood stasis down closes down, cold and heat, and broken lumps in the chest and abdomen, the prolonged fluid-retention dyspepsia is cleansed the intestines and stomach, pushes away Chen Zhixin, tonneau water anus, relieving dyspepsia in the accent, peace and the five internal organs." " property of medicine opinion " say that it can " wash five Tibetan, diuretic be swollen." modern medicine study proof Radix Et Rhizoma Rhei has remarkable reduction blood urea nitrogen, improves the effect of renal function, delay uremia and take place.It makes Radix Et Rhizoma Rhei on the one hand from the amino nitrogen of one of urea synthesis raw material of intestinal absorption and reduces, make essential amino acids concentration rising in the blood on the other hand, utilize the catabolite of vivo acid---ammonia, synthetic protein, thus liver, nephridial tissue urea synthesis amount are reduced; Radix Et Rhizoma Rhei suppresses the decomposition of body protein simultaneously, thereby the content of blood urea nitrogen and creatinine is reduced; Radix Et Rhizoma Rhei makes heavily to absorb and reduces and diuresis by the inhibition to the renal medulla enzymatic activity in addition, also promotes carbamide and creatinine to drain by diuresis; Radix Et Rhizoma Rhei can also alleviate the mesangial cell paraplasm, slows down remaining nephridial tissue glomerular sclerosis process, improves the CRF symptom, delays human chronic renal failure course of disease progress; Radix Et Rhizoma Rhei also all has inhibitory action to the various kinds of cell factor and polypeptide growth factor, makes that ECM is synthetic to be reduced, the ECM increase of degrading, rhatannin has tangible specific inhibitory effect to ACE, can bring high blood pressure down, and reduces capillary permeability, alleviate urine protein, alleviate nephrosclerosis, delay renal failure and take place.Also microcirculation is had dual regulation, can also blood fat reducing, infection, diuresis and influence uric acid and form.With in the present invention, it is turbid to get its blood stasis dispellingization, pushes away the old new effect that causes.

Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae is the dry root of labiate Radix Salviae Miltiorrhizae and Salvia przewalskii.Former plant is born in hillside, roadside, border or sylvan life meadow.Like gentle moist climate, cold-resistant, adaptability is strong.Bitter in the mouth, cold nature.GUIXIN, pericardium, Liver Channel." bitter in the mouth is slightly cold in the Shennong's Herbal record.Control trusted subordinate's pathogen, borborygmus are faint, and cold and heat gather ， Po Disorder and remove abdominal mass as leaking water, and end stuffy sensation with restlessness, QI invigorating." " Mingyi Bielu " say that it is " nontoxic.Main nourishing blood removed trusted subordinate's obstinate disease, stagnation of QI, stiffness along the spinal column, and foot numbness, exorcising stays heat.Obey sharp people for a long time." modern medicine study proof Radix Salviae Miltiorrhizae and injection thereof can improve renal function, treatment diabetes renal damage, poison of drug renal damage play significant protective effect to renal failure; Radix Salviae Miltiorrhizae suppresses the kidney fibroblast proliferation, improves kidney region fibrosis, reduces blood viscosity, anticoagulant and sticks, and prevents and reduces the kidney cicatrization, delays uremia and takes place.Microcirculation disturbance to different animals all has different improvement effects, and tangible antithrombotic formation, study of anti-atherogenic effect are arranged.The Radix Salviae Miltiorrhizae decoct can suppress various bacteria.With in the present invention, get its blood circulation promoting and blood stasis dispelling, the effect of tranquilizing by nourishing the heart.

The Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Former plant wild in the mountain area, the hilly country, the nice and cool weather of happiness, cold-resistant, bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp." Mingyi Bielu " record is " nontoxic.Expectorant water, swollen by edema due to wind pathogen knot between skin, it is full to remove spasm in the epigastrium, and cholera, tell down incessantly, blood between sharp waist umbilicus, beneficial body fluid, warming the stomach, rapid digestion of food is had a liking for food." " property of medicine opinion " say that it can cure mainly that " sputum is removed in appetizing, removes cold and heat for trusted subordinate's distending pain, the broken dyspepsia that disappears, and lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery." the modern medicine study proof Rhizoma Atractylodis Macrocephalae has remarkable and persistent diuresis.Can strengthen the phagocytic function of reticuloendothelial system, promote cellular immune function, strengthen the content of IgG in the serum, when leukopenia, also have effect in increasing leukocyte.Rhizoma Atractylodis Macrocephalae energy blood sugar lowering has the obvious suppression effect to hematoblastic minimizing.Antiinflammatory and cooling effect are arranged, various bacteria is all had in various degree inhibitory action.With in the present invention, get its invigorating spleen to remove dampness, the effect of strengthening the spleen to restrain water.

Rhizomadioscoreae: Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Former plant is born in the shrubbery or weeds in hillside, mountain valley sylvan life, small stream limit, roadside.Like warm, cold-resistant, sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Shennong's Herbal record " sweet in the mouth, temperature.Cure mainly damaging the spleen and stomach, tonify deficiency is thin, removes the cold and heat pathogen, invigorating middle warmer, physical strength profiting, longue meat." " Mingyi Bielu " say that it is " flat, nontoxic.It is dizzy to cure mainly eye, and the therapeutic method to keep the adverse QI flowing downwards is ended lumbago, and tonify deficiency labor, weakness and emaciation fill five Tibetan, heat clearing away and restlessness relieving, reinforcing YIN-essence." " property of medicine opinion " also say " can mend five kinds of strain and seven kinds of impairment, remove cold wind, end pain in the lumbar region, relieving palpitation god, the peace soul is opened through-core hole, many accounts, the reinforcing the heart QI-insufficiency is suffered from the human body weakness with emaciation, adds and uses it." modern medicine study proof Rhizoma Dioscoreae all has therapeutical effect to chronic nephritis, renal insufficiency, renal tuberculosis, experimentation can increase mouse spleen weight, the enhancing human body immunity function.Has delaying senility function preferably.With in the present invention, get its supplementing QI and nourishing YIN, the merit of spleen reinforcing lung kidney.

Herba Cistanches: Herba Cistanches is the chylocaulous of orobanchaceae plant cistanche dry zone scale leaf.Former plant is a parasitic plant, and the host is sacsaoul and haloxylon persicum etc., and desert Environment is born in happiness.Sweet in the mouth, one-tenth, warm in nature.Return kidney, large intestine channel.The Shennong's Herbal record " cure mainly five kinds of strain and seven kinds of impairment, invigorating middle warmer removes stem invasion by pathogenic cold burning pain, supports the five internal organs, reinforcing YIN-essence, and beneficial feelings gas, how sub, Fu Ren mass in the abdomen." " Mingyi Bielu " say that it " removes bladder pathogen, lumbago, dysentery relieving." " property of medicine opinion " also say " big tonification, main red white down.The benefit essence loses, the dark complexion impairment caused by overstrain." the excited hypophysis-adrenocortical hormone of modern medicine study proof Herba Cistanches energy, and can improve immunologic function, strengthen phagocytic activity and the anti-hypoxia and the resisting fatigue of mononuclear phagocyte.Renal function there is the certain protection effect, hormonal system is had regulating action.Content to neurotransmitter has certain influence, can improve intelligence, memory and the sexual function of mice.Have the promotion defecation, can improve the myenteron function, and certain hepatoprotective effect is arranged.Obvious defying age, free radical resisting damage are arranged, remove the free radical effect, can also prolong the animal life-span.With in the present invention, get the power of its kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.

Fructus Amomi Rotundus: Fructus Amomi Rotundus is the dry mature fruit of zingiberaceous plant Fructus Amomi Rotundus.Former plant is born in the sylvan life that weather is warm, moist, be rich in humus.Acrid in the mouth, warm in nature.Return lung, spleen, stomach warp." ancient prescription is controlled stomach, and cold food is tending to vomit and vomiting, and six thing soup are all used Fructus Amomi Rotundus, and on the whole the stomach master is cold, and is promptly also suitable in " Bencao Tujing " record." " medicine class on the analogy of natural things " then say " gas heat, the flavor Da Xin.Swing the gas that stagnates in the lung that looses.Main accumulation of pathogenic cold gas, wide diaphragm, end regurgitation tell contrary, rapid digestion of food, the therapeutic method to keep the adverse QI flowing downwards, feed." " Yaoxing Fu " middle record " acrid in the mouth, warm in nature, nontoxic.Rise also, sun also.It is with having four: the gas that stagnates in the broken lung, move back thin clouds in the order, and the cold air in the heart that looses is filled burnt vigour." volatile oil of modern medicine study proof Fructus Amomi Rotundus have be good for the stomach, effects such as wind dispelling, emesis.With in the present invention, get its effect removing dampness, circulation of qi promoting, warming middle-JIAO, preventing or arresting vomiting.

Effect for a better understanding of the present invention and effect provide following data for reference according to the clinical experiment result now.

Clinical experiment 1:

1), observing time: under the situation that technical solution of the present invention had not disclosed, select 2 years in year March in March, 2000 to 2002.

2), the object of observation: treatment group selection 62 routine cases: male 33 examples, women 29 examples; Age: (16～63) year, average (37.5 ± 10.4) year; The course of disease: from falling ill to consultation time (10～39) moon; Protopathy is respectively chronic nephritis 29 examples, diabetic nephropathy 13 examples, chronic pyelonephritis 10 examples, optimum ANS 5 examples, other kidney disease 5 examples.Matched group 39 examples, male 21 examples, women 18 examples; Age: (18～60) year, average (38.2 ± 12.5) year; The course of disease: from falling ill to consultation time (9～38) moon; Protopathy is respectively chronic nephritis 18 examples, diabetic nephropathy 8 examples, chronic pyelonephritis 6 examples, optimum ANS 3 examples, other kidney disease 4 examples.(t check) analysed in credit by statistics, and differences such as two groups age, sex, the course of disease, clinical symptoms and sign there are no significant meaning (P＞0.05) has comparability.

3), Therapeutic Method: two groups all give general treatment, comprise infection, correct water, electrolyte, acid-base disorder, adjust blood pressure, strictness is kept on a diet, adopt the low albumen of high-quality, low-phosphorous diet, protein was taken in and was controlled at 0.6g/kg/d every day, guaranteed the supply of energy etc. treatment group 2 clothes of Chinese medicine 1 dose of branch tonifying speen and tonifying kidney side's (prescription: the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Herba Cistanches, Fructus Amomi Rotundus, Radix Et Rhizoma Rhei, Radix Glycyrrhizae Preparata) every day; Other is oral losartan 100mg/d (MSD Corp.'s production).The only oral losartan 100mg/d of matched group.Observe 12 weeks of treatment.Survey before and after the treatment: 24h urine protein quantitation, serum creatinine and blood urea nitrogen, blood uric acid, serum albumin, hemoglobin.

4), observing effect:

Treatment group patient adds the tonifying speen and tonifying kidney side that takes traditional Chinese medicine and reduces urinary protein excretion more significantly than the decapacitation of single clothes losartan group on oral losartan basis, reduce outside serum creatinine and the blood urea nitrogen level, the plasma albumin that can also raise more significantly, the peripheral blood hemoglobin level that particularly raises is that matched group is unexistent.Illustrate that the former can delay the progress of CRF better, its kidney protective effect is strengthened, and more can improve the clinical symptoms of CRF, improves the quality of living, and does not increase any toxic and side effects, is a kind of comparatively ideal Therapeutic Method.

Clinical experiment 2:

1), observing time: under the situation that technical solution of the present invention had not disclosed, select 12 months of year January in January, 2003 to 2004.

2), the object of observation: treatment group selection 40 routine cases: male 28 examples, women 12 examples; Year at age (44.32 ± 9.05), the course of disease (47.54 ± 12.5) moon.Matched group 39 examples, male 28 examples, women 11 examples, year at age (45.05 ± 10.98), the course of disease (46.94 ± 16.7) moon.(t check) analysed in credit by statistics, and differences such as two groups age, sex, the course of disease, clinical symptoms and sign there are no significant meaning (P＞0.05) has comparability.

3), Therapeutic Method: two groups all give the low albumen of high-quality, low-phosphorous diet, and protein was taken in and was controlled at 0.7g/kg/d every day, guarantee enough energy supplies.The treatment group is given Chinese medicine tonifying speen and tonifying kidney side, and square medicine is formed: Radix Astragali 30g Radix Salviae Miltiorrhizae 30g Rhizoma dioscoreae 30g Rhizoma Atractylodis Macrocephalae 20g Herba Cistanches 10g Fructus Amomi Rotundus 10g Radix Et Rhizoma Rhei 5g Radix Glycyrrhizae Preparata 5g etc.1 dose of every day, decocting is divided into two equal portions, at twice decoction being taken warmly to 250ml.Matched group gives amino acid capsule oral (Shenzhen ten thousand and pharmaceutical factory produce), 3 times/day, 3/time, 12 weeks of the course of treatment.

4), observing effect:

This can effectively improve albumin in the serum, prealbumin, transferrins, serum cholesterol concentration, significantly improves CRF malnutrition patient's nutriture, alleviates clinical symptoms, improves the quality of living.This research is observed and is found that by the treatment in 12 weeks, patient's clinical symptoms can be greatly improved, but the variation of physical examination indexs such as body weight, AMC, TSFT, BMI is not obvious, does not possess statistical significance, may be short partially relevant with observing time.

Clinical experiment 3:

1), observing time: under the situation that technical solution of the present invention had not disclosed, select 12 months of year July in July, 2003 to 2004.

2), the object of observation: observe case totally 65 examples, be my the blood dialysis room patient of institute, be divided into 2 groups at random.Treatment group selection 33 routine cases: male 23 examples, women 10 examples; Age: (44.65 ± 11.53) year, the course of disease: (46.52 ± 13.6) moon, average dialysis time: (28.96 ± 15.7) moon, average c reactive protein: (3.39 ± 1.52) mg/L.Matched group 32 routine cases: male 22 examples, women 10 examples; Age: (44.36 ± 9.28) year, the course of disease: (45.87 ± 14.3) moon, average dialysis time: (29.58 ± 14.6) moon, average c reactive protein: (3.31 ± 1.33) mg/L.(t check) analysed in credit by statistics, and differences such as two groups age, sex, the course of disease, dialysis time, c reactive protein there are no significant meaning (P＞0.05) has comparability.

3), Therapeutic Method: two groups all give high-quality protein (1.2g/kg/d, at least 50% is high biological value albumen), and energy is taken in and is about 35kcal/kg/d.Dialysis process: all capable conventional hemodialysis (CHD), dialysis machine, dialyser are selected in unification for use, and all patients all reach abundant dialysis.The treatment group is given Chinese medicine tonifying speen and tonifying kidney side, and square medicine is formed: Radix Astragali 30g Radix Salviae Miltiorrhizae 30g Rhizoma dioscoreae 30g Rhizoma Atractylodis Macrocephalae 20g Herba Cistanches 10g Fructus Amomi Rotundus 10g Radix Et Rhizoma Rhei 5g Radix Glycyrrhizae Preparata 5g etc.1 dose of every day, decocting is divided into two equal portions, at twice decoction being taken warmly to 250ml.Matched group gives amino acid capsule oral (Shenzhen ten thousand and pharmaceutical factory produce), 3 times/day, 3/time, 12 weeks of the course of treatment.

4), observing effect:

This can improve maintenance hemodialysis patient appetite, the absorption and the absorption of material have additional nutrients, improve clinical symptoms, and then effectively improve albumin in the serum, prealbumin, transferrins, serum cholesterol concentration, significantly improve hemodialysis malnutrition patient's nutriture.Find by untoward reaction and toxic and side effects monitoring medicine, symptom of diarrhea appearred after only 1 routine patient took medicine, reason is bigger than normal with patient age, the course of disease is long, body constitution is relatively poor, more weak relevant to the tolerance of Radix Et Rhizoma Rhei, and the transference cure of suffering from diarrhoea after the drug withdrawal, through the follow up survey no sequel, so have higher-security.

Clinical experiment 4:

1), observing time: under the situation that technical solution of the present invention had not disclosed, select 12 months of year July in July, 2003 to 2004.

2), the object of observation: observe case totally 65 examples, be my the blood dialysis room patient of institute, be divided into 2 groups at random.Treatment group selection 33 routine cases: male 23 examples, women 10 examples; Example, male's 23 examples, women's 10 examples.Protopathy: chronic glomerulonephritis 14 examples, diabetic nephropathy 6 examples, chronic interstitial nephritis 6 examples, polycystic kidney 2 examples, hypertensive nephropathy 3 examples, etiology unknown person 2 examples, year at age (44.65 ± 11.53), the course of disease (46.52 ± 13.6) moon, dialysis time (28.96 ± 15.7) moon, c reactive protein (3.39 ± 1.52) mg/L.Matched group 32 examples, male's 16 examples, women's 16 examples, year at age (44.36 ± 9.28), protopathy: chronic glomerulonephritis 13 examples, diabetic nephropathy 6 examples, chronic interstitial nephritis 8 examples, polycystic kidney 1 example, hypertensive nephropathy 4 examples, the course of disease (45.87 ± 14.3) moon, dialysis time (29.58 ± 14.6) moon, c reactive protein (3.31 ± 1.33) mg/L, two groups of patient ages, sex, the course of disease, dialysis time etc. learn by statistics and handle difference nonsignificance (P＞0.05), have comparability.

3), Therapeutic Method: two groups all give high-quality protein (1.2g/kg/d, at least 50% is high biological value albumen), and energy is taken in and is about 35kcal/kg/d.Dialysis process: all capable conventional hemodialysis (CHD), dialysis machine, dialyser are selected in unification for use, and all patients all reach abundant dialysis.The treatment group is given Chinese medicine tonifying speen and tonifying kidney side, and square medicine is formed: Radix Astragali 30g Radix Salviae Miltiorrhizae 30g Rhizoma dioscoreae 30g Rhizoma Atractylodis Macrocephalae 20g Herba Cistanches 10g Fructus Amomi Rotundus 10g Radix Et Rhizoma Rhei 5g Radix Glycyrrhizae Preparata 5g etc.1 dose of every day, decocting is divided into two equal portions, at twice decoction being taken warmly to 250ml.Matched group gives amino acid capsule oral (Shenzhen ten thousand and pharmaceutical factory produce), 3 times/day, 3/time, 12 weeks of the course of treatment.

4), observing effect:

This can significantly reduce the clear lipomodulin level of patient's peripheral blood, and can improve patient's appetite, the have additional nutrients absorption and the absorption of material, and then effectively improve serum albumin, prealbumin, transferrins serum cholesterol concentration, significantly improve hemodialysis malnutrition patient's nutriture.

Clinical experiment 5:

1), observing time: under the situation that technical solution of the present invention had not disclosed, select 12 months of year May in May, 2003 to 2004.

2), the object of observation: the healthy population of 100 routine health check-up sections, detect the healthy people's in Shenzhen Leptin value.79 routine qualified patients are Urology Department outpatient service of 2003～2004 the courts and inpatient, are divided into two groups at random, and wherein 40 examples are organized in treatment, man's 28 examples, women 12 examples, 44.32 years old mean age, average course of disease 47.54 months, c reactive protein are (3.33 ± 0.81) mg/L; Matched group 39 examples, male 28 examples, women 11 examples, 45.05 years old mean age, the course of disease 46.94 months, c reactive protein (3.37 ± 1.19) mg/L, two groups of there was no significant differences, P＞0.05 tool comparability.

3), Therapeutic Method: two groups all give the low albumen of high-quality, low-phosphorous diet, and protein was taken in and was controlled at 0.7g/kg/d every day, guarantee enough energy supplies.The treatment group is given Chinese medicine tonifying speen and tonifying kidney side, and square medicine is formed: Radix Astragali 30g Radix Salviae Miltiorrhizae 30g Rhizoma dioscoreae 30g Rhizoma Atractylodis Macrocephalae 20g Herba Cistanches 10g Fructus Amomi Rotundus 10g Radix Et Rhizoma Rhei 5g Radix Glycyrrhizae Preparata 5g etc.1 dose of every day, decocting is divided into two equal portions, at twice decoction being taken warmly to 250ml.Matched group gives amino acid capsule oral (Shenzhen ten thousand and pharmaceutical factory produce), 3 times/day, 3/time, 12 weeks of the course of treatment.Two groups of patients gather peripheral vein blood specimen on an empty stomach before and after treatment, detect serum lipomodulin (Leptin), serum albumin (ALB), prealbumin (pre-A), transferrins (TSF), serum cholesterol, serum creatinine (Scr), blood urea nitrogen (BUN) etc.Adopt the ELISA method to measure the serum lipomodulin, test kit is available from northern biological study institute, the explanation of concrete grammar reference reagent box, and surplus inspection item is measured by Shenzhen clinical laboratory of institute of traditional Chinese medicine.Utilization SPSS11.1 software carries out statistical procedures.

4), observing effect:

This square tube is crossed the clear lipomodulin level of remarkable reduction patient peripheral blood and is improved patient's appetite; the absorption and the absorption of material have additional nutrients; and then effectively improve serum albumin in the serum, prealbumin, transferrins, serum cholesterol concentration; significantly improve CRF malnutrition patient's nutriture, and have certain kidney protective effect.

According to above-mentioned technical scheme and clinical data, can see, beneficial effect of the present invention is: the present invention is based on traditional theory of Chinese medical science, on the basis of the relevant theory of the five internal organs, screening also sums up prescription of the present invention and preparation method, side's medicine provided by the present invention is applicable to that mainly chronic renal disease (comprises chronic glomerulonephritis, chronic tubal nephritis, chronic renal insufficiencies etc.) Chinese medical discrimination belongs to deficiency of spleen-YANG and kidneyYANG and part spleen deficiency of kidney-QI patient, use the present invention not have irritated reaction, have no side effect, obvious reduction of patient fatigue and weakness, the lazyness of breathing hard speech, yellowish complexion is become thin, clinical symptoms such as anorexia abdominal distention, improve patients " renal function and nutriture, reach and improve patient's life quality, prolong patient's purpose of life cycle, the present invention is with low cost, reparation technology is simple and easy to do.

The specific embodiment

For a better understanding of the present invention, enumerating the specific embodiment is below narrated in detail to it.

Embodiment 1

The quality proportioning of preparing prescription and each component is as follows:

Radix Astragali 30-35g gives birth to Radix Salviae Miltiorrhizae 30-35g Rhizoma dioscoreae 30-35g

Rhizoma Atractylodis Macrocephalae 20-25g Herba Cistanches 10-15g Fructus Amomi Rotundus 10-15g

Radix Et Rhizoma Rhei 5-10g Radix Glycyrrhizae 5-10g

Preparing such formulations comprises the steps:

1), oven dry: various prescriptions are prepared in proportion, under 50～70 ℃ high temperature, dry, the room temperature of drying in the air naturally then;

2), pulverize: various prescriptions are pulverized through pulverizer, crossed 80 molybdenums sieve then, it is standby to become powdery;

3), soak: select sand kettle or enamel pan for use, avoid with iron pan, aluminum pot, put into said components in sand kettle or the enamel pan and add the clear water merceration, 20～30 minutes merceration time, water consumption is controlled at soaked 2～5 centimetres of medicines;

4), decoct: (big fire) fries in shallow oil to boiling with high heat earlier, changes slow fire (little fire) then and fries in shallow oil slowly, and decocting time from boiling timing 40～60 minutes, takes out medicinal liquid then for the first time;

5), secondary decocts: add clear water then in sand kettle or enamel pan, water consumption is controlled at soaked 1～3 centimetre of medicine, utilized slow fire (little fire) to carry out secondary then and decocted, for the second time decocting time, from boiling timing 20～30 minutes, then medicinal liquid is taken out;

6), above-mentioned twice juice of boiling medicine is fully mixed, take at twice then.

When taking, preferably children taking takes 50～150 milliliters, and the adult takes and takes 200～300 milliliters.

Embodiment 2

The quality proportioning of preparing prescription and each component is as follows:

Radix Astragali 30-33g gives birth to Radix Salviae Miltiorrhizae 30-33g Rhizoma dioscoreae 30-33g

Rhizoma Atractylodis Macrocephalae 20-23g Herba Cistanches 10-13g Fructus Amomi Rotundus 10-13g

Radix Et Rhizoma Rhei 5-8g Radix Glycyrrhizae 5-8g

Preparation method and instructions of taking are with embodiment 1.

Embodiment 3

The quality proportioning of preparing prescription and each component is as follows:

Radix Astragali 33g gives birth to Radix Salviae Miltiorrhizae 32g Rhizoma dioscoreae 31g

Rhizoma Atractylodis Macrocephalae 21g Herba Cistanches 12g Fructus Amomi Rotundus 12g

Radix Et Rhizoma Rhei 7g Radix Glycyrrhizae 7g

Preparation method and instructions of taking are with embodiment 1.

Claims (4)

1, a kind of prescription of tonifying speen and tonifying kidney preparation is characterized in that, the quality proportioning of prescription and each component is as follows:

Radix Astragali 30-35 part is given birth to Radix Salviae Miltiorrhizae 30-35 part Rhizoma dioscoreae 30-35 part

Rhizoma Atractylodis Macrocephalae 20-25 part Herba Cistanches 10-15 part Fructus Amomi Rotundus 10-15 part

Radix Et Rhizoma Rhei 5-10 part Radix Glycyrrhizae 5-10 part

2, a kind of prescription of tonifying speen and tonifying kidney preparation, its feature also be, the present invention can preferably fill a prescription and the quality proportioning of each component as follows:

Radix Astragali 30-33 part is given birth to Radix Salviae Miltiorrhizae 30-33 part Rhizoma dioscoreae 30-33 part

Rhizoma Atractylodis Macrocephalae 20-23 part Herba Cistanches 10-13 part Fructus Amomi Rotundus 10-13 part

Radix Et Rhizoma Rhei 5-8 part Radix Glycyrrhizae 5-8 part

3, a kind of prescription of tonifying speen and tonifying kidney preparation, its feature also be, the present invention can preferably fill a prescription and the quality proportioning of each component as follows:

30 parts of 30 parts of Rhizoma dioscoreaes of 30 parts of living Radix Salviae Miltiorrhizaes of Radix Astragali

10 parts of 10 portions of Fructus Amomi Rotunduss of 20 parts of Herba Cistanches of Rhizoma Atractylodis Macrocephalae

5 parts of 5 parts of Radix Glycyrrhizae of Radix Et Rhizoma Rhei

4, a kind of preparation method of tonifying speen and tonifying kidney preparation, its feature is that also it comprises the steps:

1), oven dry: various prescriptions are prepared in proportion, under 50～70 ℃ high temperature, dry, the room temperature of drying in the air naturally then;

2), pulverize: various prescriptions are pulverized through pulverizer, crossed 80 molybdenums sieve then, it is standby to become powdery;

3), soak: select sand kettle or enamel pan for use, avoid with iron pan, aluminum pot, put into said components in sand kettle or the enamel pan and add the clear water merceration, 20～30 minutes merceration time, water consumption is controlled at soaked 2～5 centimetres of medicines;

4), decoct: (big fire) fries in shallow oil to boiling with high heat earlier, changes slow fire (little fire) then and fries in shallow oil slowly, and decocting time from boiling timing 40～60 minutes, takes out medicinal liquid then for the first time;

5), secondary decocts: add clear water then in sand kettle or enamel pan, water consumption is controlled at soaked 1～3 centimetre of medicine, utilized slow fire (little fire) to carry out secondary then and decocted, for the second time decocting time, from boiling timing 20～30 minutes, then medicinal liquid is taken out;

6), above-mentioned twice juice of boiling medicine is fully mixed, take at twice then.

When taking, children taking takes 50～150 milliliters generally speaking, and the adult takes and takes 200～300 milliliters.