CN103142812A - Traditional Chinese medicine for preventing and treating alcoholic liver injury and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for preventing and treating alcoholic liver injury and preparation method of traditional Chinese medicine Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for preventing and treating alcoholic liver injury and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine contains the following crude medicines in parts by weight: 10-30 parts of pueraria lobata ohwi, 15-45 parts of hovenia dulcis thumb, 20-45 parts of poria cocos, 15-40 parts of bighead atractylodes rhizome, 15-35 parts of Chinese yam, 8-30 parts of hawthorn fruits, 20-45 parts of radix salviae miltiorrhizae, 15-45 parts of radix paeoniae alba, 20-45 parts of oriental wormwood, 20-45 parts of semen cassiae and 6-20 parts of liquorice. The preparation method comprises the steps of: grinding poria cocos, Chinese yam and hawthorn fruits; extracting radix salviae miltiorrhizae and semen cassiae by ethanol and preparing powder; adding pueraria lobata ohwi, bighead atractylodes rhizome and oriental wormwood in water, distilling for extracting volatile oil and preparing a cyclodextrin inclusion complex of volatile oil; and decocting hovenia dulcis thumb, radix paeoniae alba and liquorice, as well as residues of pueraria lobata ohwi, bighead atractylodes rhizome, oriental wormwood, radix salviae miltiorrhizae and semen cassiae in water, concentrating for preparing medicine powder; and mixing the medicine powder with auxiliary materials to obtain a mixture and pilling the mixture. All the crude medicines in the formula are compatible, and the traditional Chinese medicine has the effects of alleviating alcoholism, refreshing mind, activating blood, nourishing liver, clearing heat and promoting diuresis, and is an effective prescription for preventing and treating alcoholic liver injury.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine of preventing and treating alcoholic liver injury and preparation method thereof.
Background technology
Liver is the organ that body weight for humans is wanted, and is also the important immune organ of body simultaneously.After various virulence factors act on hepatic tissue, can directly cause hepatocyte infringement in various degree.Alcoholic liver injury (alcoholic liver disease, ALD) be due to long-term a large amount of Ethanol intake cause with the liver fat degeneration, inflammatory cell infiltration, even fiber turns to a kind of toxic hepatic disease of feature.Have data to show, drink the wine person more than 5 years who contains 40g ethanol every day, 48% alcoholic liver disease of suffering from is in various degree arranged, and the prevalence of male's alcoholic liver disease is apparently higher than the women, men and women's ratio is 17: 1.Separately there are some researches show the fatty liver that has more than 80% in heavy drinking essence person to a certain degree, 10%～35% can develop into alcoholic hepatitis, and 10%～20% will develop into liver cirrhosis.In recent years, along with China's phenomenal growth of alcohol to oil ratio per capita, the sickness rate of alcoholic liver injury is ascendant trend year by year, has become the second largest cause of disease that causes hepatic injury after viral hepatitis in some areas.
At present, liver disease much adopts " antiviral agents ", in fact, " the guideline " according to up-to-date announcement, only having the transaminase is that the patient that more than 2 times of normal value, hepatitis B virus DNA are positive just need to accept antiviral therapy, Most patients more needs to protect the liver, hepatoprotective, prevent the treatment means of this self-regulation of hepatic fibrosis, and this advantage of Chinese medicine just.Modern experimentation also shows, Chinese medicine is demonstrating advantage preferably aspect prevention and treatment alcoholic fatty liver.
Though do not have special name of disease corresponding with it in motherland's traditional medicine Chinese medicine, but just mention " irritability after immoderate drinking " in classical works " internal diameter ", " wine is long-pending " that proposes in the name of " alcoholic jaundice " mentioned in " Medical Treasures of the Golden Chamber jaundice abnormal pulse is demonstrate,proved and controlled ", " Confucian's Duties to Their Parents "; " alcoholophilia " that " the sick duke or princess under an emperor of General Treatise on the Cause and Symptoms of Diseases addiction " proposes; " flatulence due to immoderate drinking " that " Elementary Medicine tympanites card is controlled " mentioned; And the name of disease of " the wine drum " of Jing-Yue Complete Works proposition should be corresponding with the alcoholic liver disease in modern medicine.
There are numerous ancient Chinese proses to offer and put down in writing the impact of wine on the viscera organ.Li Shizhen (1518-1593 A.D.) point out in Compendium of Material Medica " wine, the clever Lu in sky also, few drink with blood, circulation of qi promoting, the mind invigorating, keep out the cold, relieve the lonliness and grief, drink to one's heart content and overtax one's nerves, hematozemia, damage stomach, the essence of dying, give birth to expectorant, get angry "." General Treatise on the Cause and Symptoms of Diseases " cloud: " the wine person, foodstuff essence also.Its gas welding and very toxic enters liver and gall ..." " ethanol is poisonous, and multiple large heat, drink too much, therefore scorchingly hot impervious meridians, the internal organs that overflow, and sick also all." " a Jing Yue's complete work diet piece of writing " say: " and the wine person, one with the wet impairment of the spleen of wine ..., one is cloudy with the wine thermal burn ..., one is dirty with the vinosity wound." generally speaking, wine is damp and hot two property, polydipsia accumulates long-pending removing toxic substances, and the thief kills internal organs.Chinese medicine thinks, alcoholic liver injury is many to be accumulate long-pendingly by alcoholism, and due to damp and hot suffocating of liver and gall, its Therapeutic Principle should be with alcoholic intoxication, and the spleen invigorating of invigorating blood circulation, liver heat removing dampness removing are main.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine of preventing and treating alcoholic liver injury and preparation method thereof, this kind Chinese medicine energy soothing liver and strengthening spleen, dampness removing is invigorated blood circulation, taking convenience, good drug efficacy, and preparation technology is scientific and reasonable.
The technical scheme that the present invention takes is:
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its raw material medicines in portions by weight ratio consists of: 10～30 parts of Flos puerariae lobataes, 15～45 parts of Semen Hoveniae (Fructus Hoveniae)s, 20～45 parts, Poria, 15～40 parts of the Rhizoma Atractylodis Macrocephalaes, 15～35 parts of Rhizoma Dioscoreaes, 8～30 parts of Fructus Crataegis, 20～45 parts of Radix Salviae Miltiorrhizaes, 15～45 parts of the Radix Paeoniae Albas, 20～45 parts of Herba Artemisiae Scopariaes, 20～45 parts of Semen Cassiaes, 6～20 parts, Radix Glycyrrhizae.
The Chinese medicine of above-mentioned control alcoholic liver injury, preferred feedstock medicine weight part ratio consists of: 15～25 parts of Flos puerariae lobataes, 20～40 parts of Semen Hoveniae (Fructus Hoveniae)s, 25～40 parts, Poria, 20～35 parts of the Rhizoma Atractylodis Macrocephalaes, 20～30 parts of Rhizoma Dioscoreaes, 10～22 parts of Fructus Crataegis, 25～40 parts of Radix Salviae Miltiorrhizaes, 20～40 parts of the Radix Paeoniae Albas, 25～40 parts of Herba Artemisiae Scopariaes, 25～40 parts of Semen Cassiaes, 8～15 parts, Radix Glycyrrhizae.
The Chinese medicine of above-mentioned control alcoholic liver injury, further preferred feedstock medicine weight part ratio consists of: 18～22 parts of Flos puerariae lobataes, 22～35 parts of Semen Hoveniae (Fructus Hoveniae)s, 28～35 parts, Poria, 25～30 parts of the Rhizoma Atractylodis Macrocephalaes, 22～28 parts of Rhizoma Dioscoreaes, 12～15 parts of Fructus Crataegis, 28～35 parts of Radix Salviae Miltiorrhizaes, 25～35 parts of the Radix Paeoniae Albas, 28～35 parts of Herba Artemisiae Scopariaes, 28～35 parts of Semen Cassiaes, 9～12 parts, Radix Glycyrrhizae.
In above-mentioned Chinese medicine, the preferred Fructus Crataegi (parched) of Fructus Crataegi wherein; The preferred Semen Cassiae (parched) of Semen Cassiae; The preferred Rhizoma Atractylodis Macrocephalae (parched with bran) of the Rhizoma Atractylodis Macrocephalae.
The preparation method of the Chinese medicine of above-mentioned control alcoholic liver injury comprises the steps:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae are adopted ethanol extraction, filter, filtrate recycling ethanol and to be condensed into relative density be 1.10-1.15(60-75 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, with the cyclic dextrin clathrate of volatile oil with 6-12 times of volatile oil quality, the cyclodextrin inclusion complex that gets volatile oil is standby, and the another device of water liquid is preserved;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water, filter, the water liquid that filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted after volatile oil merges, being concentrated into relative density is 1.10-1.15(60-75 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the cyclodextrin inclusion complex of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; the fine powder that step (1) obtains; the medicated powder that step (2) obtains; the medicated powder that step (4) obtains is merged into mixed powder, with diluent adjuvant, tender flavor agent adjuvant mix homogeneously, granulation; dry; the lubricant that adds granulate mixture weight 0.5-0.8%, tabletting, and get final product.
The described concentration of alcohol of above-mentioned steps (2) is 75%-95%(v/v), the 5-10 that each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass doubly extracts 2-3 time, extracts 1-2 hour at every turn.
Above-mentioned step (3) amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 3-5 times, extracts volatile oil 5-8 hour.
The described inclusion of above-mentioned step (3) is ground or is stirred for cyclodextrin being added suitable quantity of water, then drips volatile oil, then grinds or stir, and inclusion complex grinds 40-50 ℃ of drying, gets the cyclodextrin inclusion complex of volatile oil.
Above-mentioned steps (4) is that the Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2-3 time, add to decoct medicine gross mass 6-10 water doubly at every turn, decocted 1-2 hour at every turn.
The preferred beta-schardinger dextrin-of the described cyclodextrin of above-mentioned steps (3).
Above-mentioned steps (5) is used can be used as the pharmaceutic adjuvant of diluent, pharmaceutic adjuvant, the lubricant that can be used as the agent of tender flavor is the adjuvant of pharmaceutically knowing altogether.The 25-35% of medicated powder weight after the medicated powder that diluent adjuvant addition is the cyclodextrin inclusion complex of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil, medicated powder that step (1) obtains, step (2) obtains, the medicated powder that step (4) obtains mix, the 0.2-0.6% of medicated powder gross weight after the cyclodextrin inclusion complex that tender flavor agent adjuvant addition is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil, the medicated powder that step (1) obtains, medicated powder that step (2) obtains, the medicated powder that step (4) obtains mix.
In side of the present invention, Flos puerariae lobatae is the dried floral of legume pueraria lobata, bitter Pueraria lobata.Effect with relieving acute alcoholism and recuperating the spleen.Be mainly used in treating the heating excessive thirst of getting sick from drinking too much wine, anorexia, the vomiting acid regurgitation is spitted blood, discharging fresh blood stool." Mingyi Bielu ": " wine disappears." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and control dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, diet is not thought, and chest and diaphragm is glutted, sends out oh, vomits sour expectorant, and alcoholism injures one's stomach, spits blood, hematemesis, heat disappears." " detailed outline ": " control discharging fresh blood stool." " the medical center bun is wanted ": " lung heat clearing.”
Semen Hoveniae (Fructus Hoveniae) is the dry mature seed of Rhamnaceae plant Semen Hoveniae (Fructus Hoveniae).Alcoholic intoxication, cough-relieving relieving restlessness, preventing or arresting vomiting, sharp defecation.Cure mainly drunk, excessive thirst, the vomiting, difficulty in urination and defecation." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " can alcoholic intoxication, or steep in wine and take it, also can the Shujin network.Clothes are made light of one's life by commiting suicide and are prolonged life for a long time." " detailed outline ": " preventing or arresting vomiting is contrary." " Newly Revised Canon of Materia Medica ": " main wind syndrome of head, lower abdomen contracture." supplement to the Herbal: " and heat on diaphragm is gone in the cough-relieving relieving restlessness, moistening five ZANG-organs, and sharp defecation shares as honey." Flos puerariae lobatae and Semen Hoveniae (Fructus Hoveniae) be the two traditional Sobering-up Chinese medicines of flavor, can " alcoholic intoxication " according to ancient literature record Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae) can " lose vinosity ".Both compatibilities gather the effect of relieving acute alcoholism and recuperating the spleen altogether.
Poria is the dry sclerotia of On Polyporaceae Poria.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming is mainly used in the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels etc. in the loose stool.Shennong's Herbal: " the contrary gas of main costa sternales, melancholy is angerd frightened heresy and is probably throbbed with fear ... diuresis, clothes peace soul is reposed for a long time." " Mingyi Bielu ": " edema is drenched knot for large Fu Lin Lek, the disease due to obstruction of QI of middle-JIAO expectorant water ... cut down the kidney heresy." Materia Medica of Decoction: " rush down bladder, the strengthening the spleen stomach is controlled the long-pending renal mass of kidney." Compendium of Material Medica: " Cortex Sclerotii Poriae master edema general edema, dredging water passages, loosing the interspaces of skin and muscles." " book on Chinese herbal medicine meets former ": " the stool person of rushing down, disorder of stomach-QI can not divide diuretic paddy, partially ooze large intestine and let out notes also.Poria divides sharp negative and positive, rushes down from stopping." " generation benefit vegetarian ": " Poria simply, for controlling the expectorant principal agent.Expectorant this, water also, Poria can be gone water; Expectorant is moving, wets also, and Poria is feasible wet again." " property of medicine opinion ": " the appetizing preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up, and controls the frightened Epilepsy of little youngster, treats trusted subordinate's distension, married woman's pyretic stranguria.”
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic.Shennong's Herbal: " the hidroschesis heat extraction helps digestion for the dead flesh of main anemofrigid-damp arthralgia, convulsion, subcutaneous ulcer." " Mingyi Bielu ": " expectorant water is allowanced for bark an edema due to wind pathogen knot swollen, and the warming the stomach rapid digestion of food is had a liking for food." " property of medicine book on Chinese herbal medicine ": " control the insufficiency of stomach diarrhea." " all book on Chinese herbal medicine of solar corona ": " diuresis." " pearl sac ": " and expectorant is relieved oedema or abdominal distension through diuresis or purgation for dehumidifying QI invigorating, invigorating middle warmer YANG invigorating, promoting the production of body fluid to quench thirst, and antidiarrheal dysentery, sufficient shin damp-edema disappears " and " property of medicine opinion ": " swelling of harnessing the river is full, and preventing or arresting vomiting is contrary, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI." " medicine origin ": " and the Rhizoma Atractylodis Macrocephalae, the benefit that can dehumidify is dry, and middle QI invigorating, and blood between sharp waist umbilicus is except pathogenic heat in the stomach." " book on Chinese herbal medicine converge with speech ": " and the Rhizoma Atractylodis Macrocephalae is to foster taste, the wet dissipation eliminating impediment, help digestion except the key medicine of painful abdominal mass also.”
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Shennong's Herbal: " main damaging the spleen and stomach, tonify deficiency is won, except the cold and heat pathogen, invigorating middle warmer, physical strength profiting, longue meat, reinforcing YIN-essence." " all book on Chinese herbal medicine of solar corona ": " kidney tonifying gas, strengthening the spleen and stomach, antidiarrheal dysentery, the saliva that reduces phlegm, profit fur." " Mingyi Bielu ": " and main women's head-ornaments urticaria, public attention eye is dizzy, and the therapeutic method to keep the adverse QI flowing downwards is stopped pain in the lumbar region, and tonify deficiency labor is won thin, fills the five internal organs, heat clearing away and restlessness relieving, reinforcing YIN-essence." " property of medicine opinion ": " and mend five kinds of strain and seven kinds of impairment, remove cold wind, lumbago only, relieving palpitation god, the reinforcing the heart QI-insufficiency suffers from that human body is empty wins, and adds and uses it." " Japan hanako materia medica ": " and help the five internal organs, bone and muscle strengthening, long will is calmed the nerves, and the main essence of letting out is forgetful." Compendium of Material Medica: " kidney tonifying gas, strengthening the spleen and stomach, antidiarrheal dysentery, the saliva that reduces phlegm, profit fur.”
Fructus Crataegi is the mature fruit of rosaceous plant Fructus Crataegi and Fructus Pyri Pashiae.The energy promoting digestion and invigorating the stomach, the circulation of qi promoting dissipating blood stasis." beautiful Chinese catalpa medicine solution " record " sour in the mouth, sweet, gas is flat, enters spleen of Foot-Taiyin, liver channel of foot-Jueyin "." must join book on Chinese herbal medicine " record " enters lunar, the Yangming Channel of foot ".As seen, the nature and flavor of Fructus Crataegi, return through for sour in the mouth sweet, slightly warm in nature.Return spleen, stomach, Liver Channel." dissipating fluid-retention food, the meat that disappears is long-pending, abdominal mass, phlegm retention, feeling of fullness acid regurgitation, stagnant blood pain with distension in record in Compendium of Material Medica." " occupying the diet spectrum with breath " " gas of being amusing, the meat that disappears, removing blood stasis with potent drugs blood, the eliminating stagnation relieving distension is relieved the effect of alcohol and is reduced phlegm, except infantile malnutrition, stopping leak dysentery." Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Crataegi, spleen invigorating is amusing, relieves the effect of alcohol, and dampness removing.
Radix Salviae Miltiorrhizae is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae.The function blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood disappears bitterly.Be used for obstruction of qi in the chest and cardialgia, gastral cavity abdominal rib Tong ， lumps in the chest and abdomen, pyretic arthralgia pain etc.Shennong's Herbal: " main trusted subordinate's pathogen, borborygmus are faint as leaking water, and cold and heat gather ， Po Disorder except abdominal mass, stop stuffy sensation with restlessness, QI invigorating." " Mingyi Bielu ": " and nourish blood, go trusted subordinate's obstinate disease, stagnation of QI, back rigidity, foot numbness, exorcising stays heat." " all book on Chinese herbal medicine of solar corona ": " sedate of reposing, tonneau GUAN-pulse are controlled cold and hot labor arthralgia, extremity are unsuccessful, the headache acute conjunctivitis, and the heat temperature is mad vexed, broken stagnated blood, tissue regeneration promoting blood, peaceful tire, the stillborn fetus that falls under the hemostasis metrorrhagia and leukorrhagia, transfers married woman's passages through which vital energy circulates irregular, the blood evil thought is tired, malignant boil Jie Xian, the wart toxic swelling of going to live in the household of one's in-laws on getting married, erysipelas, the evacuation of pus pain relieving, granulation promoting is put on flesh." " property of medicine opinion ": " flat.Can control flaccidity of the lower limbs pain numbness, main attacked by pestiferous factors is controlled hundred evil ghosts and goblins' stomachache, and gas is done the sound ring and shouted, can fixed essence." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." Compendium of Material Medica: " invigorate blood circulation, logical percardium is controlled the xenon pain." " book on Chinese herbal medicine justice ": " Radix Salviae Miltiorrhizae specially enters blood system, and its merit is the promoting the circulation of blood of invigorating blood circulation, and interior reaches internal organs and blood stasis dispelling is stagnant, therefore it is broken to gather Xiao Er mass in the abdomen; Outer profit joint and the network of promoting blood circulation, the strong and numbness work row of waist knee joint.Auspicious core ancients cure mainly, the effect of the logical operation of none non-a surname, so and its energy operator must have the gas of gentleness, can agitate it, vibrate it, so-called main trusted subordinate's pathogen borborygmus obstinate disease, its justice is faintly visible.”
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae.Has astringing YIN to stop sweating, easing the affected liver to relieve pain, the effect of suppressing liver-YANG.Be used for blood deficiency, hypochondriac pain, stomachache, limb pain twin, the dizzy disease of waiting of having a headache.Shennong's Herbal: " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard knot, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." Compendium of Material Medica: " and enrich blood, eliminating pathogen in the liver, strengthening the spleen is held back liver-yin, controls the stomachache of blood deficiency." " Mingyi Bielu " " clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood.The gas that anhydrates, sharp bladder, intestine and small intestine.Subduing inflammation, the time row cold and heat, attacked by pestiferous factors stomachache, lumbago.”
Herba Artemisiae Scopariae is the seedling of Compositae herbaceos perennial Herba Artemisiae Scopariae or Artemisia scoparia Waldst. et Kit..Effect with eliminating damp-heat.Shennong's Herbal: " the raw pathogenic heat gas of main air, accumulation of heat jaundice." " Mingyi Bielu ": " jaundice of main the whole body, dysuria." " in inner feelings ginseng west record ": " and the heat of the kind liver heat removing gallbladder of Herba Artemisiae Scopariae, the reason of holding concurrently liver and gall strongly fragrant, heat strongly fragrant the opening that disappear, the road that bile enters small intestinal has no to hinder also." " book on Chinese herbal medicine justice ": " the lightly seasoned diuretic of Herba Artemisiae Scopariae is to control two damp and hot special medicines of taste, and wet subcutaneous ulcer, alcoholic jaundice yellowish body are urinated red as beans, and all stomach soil accumulates the card of wet accumulated heat, at all times all take this thing as main." " book on Chinese herbal medicine is new again ": " and pathogenic fire purging, suppressing the hyperactive liver reduce phlegm, cough-relieving, and diaphoresis, inducing diuresis and reducing edema, treat all poison of skin ulcer fire.”
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia are had a headache dizzy, poor vision, constipation." book on Chinese herbal medicine is looked for the truth ": " except the wind heat radiation.... receive tear pain relieving key medicine for controlling order." " property of medicine book on Chinese herbal medicine ": " treating the liver hot blast eye red tear." " property of medicine opinion ": " and make eye bright, sharp the five internal organs ... man is hot except liver." " Treatise on Dietetic Therapy ": " main liver man pyretic toxicity gas, the red tear of wind-eye." " Amplification on Materia Medica addendum ": " kidney tonifying antidotes against snake bite." Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, spleen invigorating, be amusing, relieve the effect of alcohol, help the power of Flos puerariae lobatae, Semen Hoveniae (Fructus Hoveniae).Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Herba Artemisiae Scopariae, Semen Cassiae are invigorated blood circulation, easing the affected liver, heat clearing away, dampness removing.
Radix Glycyrrhizae is dry root and the rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and remove fibrous root, dry.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, the swollen sore of pain, cushion toxicity, strong.Shennong's Herbal: " live vital organs of the human body cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound Zhong, detoxifcation." " Mingyi Bielu ": " and warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quench the thirst, qualcomm meridian, sharp vim and vigour are separated hundred poison." " all book on Chinese herbal medicine of solar corona ": " strengthening the spleen stomach, profit cardiopulmonary." Compendium of Material Medica: " mend all void ... the replenishing essence marrow." " book on Chinese herbal medicine justice ": " and Rhizoma Polygonati does not carry herbal classic, and the present is originated in Huizhou City, and people from emblem often thinks the product of present, steaming extremely ripe, edible at any time, and sweet in the mouth and thick greasy, class Radix Rehmanniae Preparata quite ... enriching blood nourishing YIN and support taste, is its speciality.But greasy stagnant thing, the person not takes the damp-phlegm, and stomach is received not prosperous person, also must keep away it." the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
The all medicine compatibilities in the full side of the present invention relieve the effect of alcohol, are amusing, invigorate blood circulation, easing the affected liver, heat clearing away, dampness removing, are the good recipe of control alcoholic liver injury.
The characteristics of preparation method of the present invention are the physicochemical properties according to the prescription 11 contained effective ingredient of herbal medicine or main component, with prescription drug be divided into direct pulverizing, ethanol extraction, extraction volatile oil, decocting (comprising the medicine carried after volatile oil and the medicine after ethanol extraction), beta-schardinger dextrin-carries out five parts of inclusion, its extraction and preparation technique is scientific and reasonable.Preparation technology is more traditional, and decocting becomes decoction, has kept to a greater extent effective ingredient, and makes tablet, is suitable for suitability for industrialized production, takes more convenient.
The medicine of directly pulverizing: Poria in the side, Rhizoma Dioscoreae, Fructus Crataegi mealiness are stronger, are easy to pulverize, and therefore directly are ground into fine powder and are used as medicine, and replace adjuvant.
Contain the extraction of volatile oil medicine: to containing medical material Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, the Herba Artemisiae Scopariae of volatile oil in prescription, for fully keeping its effective ingredient, first extract volatile oil, the another device of water liquid is collected, and medicinal residues are incorporated in the decocting medicine and fry in shallow oil altogether.
At first Radix Salviae Miltiorrhizae, Semen Cassiae in prescription are adopted its effective ingredient of ethanol extraction, and then medicinal residues remerge in the medicine of decocting.
The extraction of decocting medicine: to Radix Salviae Miltiorrhizae, the Semen Cassiae after Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae and ethanol extraction after the medical material Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and the extraction volatile oil that contain aqueous soluble active constituent in prescription, mix decocting, filter, concentrated.
The cyclic dextrin clathrate of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil: for increasing Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, the stability of Herba Artemisiae Scopariae volatile oil in preparation of extracting, adopt cyclodextrin to carry out inclusion it.
The specific embodiment
Further illustrate below in conjunction with embodiment.
Embodiment 1
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 20 grams, Semen Hoveniae (Fructus Hoveniae) 28 grams, Poria 30 grams, the Rhizoma Atractylodis Macrocephalae 28 grams, Rhizoma Dioscoreae 25 grams, Fructus Crataegi 13 grams, Radix Salviae Miltiorrhizae 30 grams, the Radix Paeoniae Alba 30 grams, Herba Artemisiae Scopariae 30 grams, Semen Cassiae 30 grams, Radix Glycyrrhizae 10 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 85% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 6 times, extracts 2 times, each 1.5 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.12(65 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 4 times, extracts volatile oil 6 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 8 times of volatile oil quality, the water that beta-schardinger dextrin-is added 2 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 45 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 8 times of medicine gross masses at every turn, decocted 1.5 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.10(65 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 30%, the stevioside mix homogeneously of mixed powder weight 0.5%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.6%, tabletting, and get final product.
Embodiment 2
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 10 grams, Semen Hoveniae (Fructus Hoveniae) 15 grams, Poria 20 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Rhizoma Dioscoreae 15 grams, Fructus Crataegi 8 grams, Radix Salviae Miltiorrhizae 20 grams, the Radix Paeoniae Alba 15 grams, Herba Artemisiae Scopariae 20 grams, Semen Cassiae 20 grams, Radix Glycyrrhizae 6 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 75% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 5 times, extracts 3 times, each 1 hour, filter, filtrate recycling ethanol and to be condensed into relative density be 1.15(60 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 3 times, extracts volatile oil 5 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 6 times of volatile oil quality, the water that beta-schardinger dextrin-is added 1.8 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 50 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 3 times, add the water that decocts 6 times of medicine gross masses at every turn, decocted 1 hour at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.10(75 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 25%, the stevioside mix homogeneously of mixed powder weight 0.2%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.5%, tabletting, and get final product.
Embodiment 3
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 30 grams, Semen Hoveniae (Fructus Hoveniae) 45 grams, Poria 45 grams, the Rhizoma Atractylodis Macrocephalae 40 grams, Rhizoma Dioscoreae 35 grams, Fructus Crataegi 30 grams, Radix Salviae Miltiorrhizae 45 grams, the Radix Paeoniae Alba 45 grams, Herba Artemisiae Scopariae 45 grams, Semen Cassiae 45 grams, Radix Glycyrrhizae 20 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 95% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 10 times, extracts 2 times, each 2 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.15(60 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 5 times, extracts volatile oil 8 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 12 times of volatile oil quality, the water that beta-schardinger dextrin-is added 2.5 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 40 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 10 times of medicine gross masses at every turn, decocted 2 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.10(60 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 35%, the stevioside mix homogeneously of mixed powder weight 0.6%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.5%, tabletting, and get final product.
Embodiment 4
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 15 grams, Semen Hoveniae (Fructus Hoveniae) 20 grams, Poria 25 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Rhizoma Dioscoreae 20 grams, Fructus Crataegi 10 grams, Radix Salviae Miltiorrhizae 25 grams, the Radix Paeoniae Alba 20 grams, Herba Artemisiae Scopariae 25 grams, Semen Cassiae 25 grams, Radix Glycyrrhizae 8 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 95% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 6 times, extracts 2 times, each 1.5 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.11(75 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 4 times, extracts volatile oil 5 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 6 times of volatile oil quality, the water that beta-schardinger dextrin-is added 3 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 40 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 10 times of medicine gross masses at every turn, decocted 1.5 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.15(60 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 25%, the stevioside mix homogeneously of mixed powder weight 0.3%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.6%, tabletting, and get final product.
Embodiment 5
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 25 grams, Semen Hoveniae (Fructus Hoveniae) 40 grams, Poria 40 grams, the Rhizoma Atractylodis Macrocephalae 35 grams, Rhizoma Dioscoreae 30 grams, Fructus Crataegi 22 grams, Radix Salviae Miltiorrhizae 40 grams, the Radix Paeoniae Alba 40 grams, Herba Artemisiae Scopariae 40 grams, Semen Cassiae 40 grams, Radix Glycyrrhizae 15 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 75% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 6 times, extracts 2 times, each 1 hour, filter, filtrate recycling ethanol and to be condensed into relative density be 1.13(68 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 4 times, extracts volatile oil 8 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 12 times of volatile oil quality, the water that beta-schardinger dextrin-is added 3.5 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 40 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 8 times of medicine gross masses at every turn, decocted 1.5 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.10(65 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 28%, the stevioside mix homogeneously of mixed powder weight 0.4%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.7%, tabletting, and get final product.
Embodiment 6
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 18 grams, Semen Hoveniae (Fructus Hoveniae) 22 grams, Poria 28 grams, the Rhizoma Atractylodis Macrocephalae 25 grams, Rhizoma Dioscoreae 22 grams, Fructus Crataegi 12 grams, Radix Salviae Miltiorrhizae 28 grams, the Radix Paeoniae Alba 25 grams, Herba Artemisiae Scopariae 28 grams, Semen Cassiae 28 grams, Radix Glycyrrhizae 9 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 75% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 10 times, extracts 3 times, each 2 hours, filter, filtrate recycling ethanol and to be condensed into relative density be 1.11(70 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 5 times, extracts volatile oil 6 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 10 times of volatile oil quality, the water that beta-schardinger dextrin-is added 4 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 45 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 8 times of medicine gross masses at every turn, decocted 2 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.12(70 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 32%, the stevioside mix homogeneously of mixed powder weight 0.3%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.8%, tabletting, and get final product.
Embodiment 7
A kind of Chinese medicine of preventing and treating alcoholic liver injury, its crude drug consists of: Flos puerariae lobatae 22 grams, Semen Hoveniae (Fructus Hoveniae) 35 grams, Poria 35 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Rhizoma Dioscoreae 28 grams, Fructus Crataegi 15 grams, Radix Salviae Miltiorrhizae 35 grams, the Radix Paeoniae Alba 35 grams, Herba Artemisiae Scopariae 35 grams, Semen Cassiae 35 grams, Radix Glycyrrhizae 12 grams.
Preparation method is:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) adopt 90% ethanol (V/V) to extract Radix Salviae Miltiorrhizae, Semen Cassiae, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass 6 times, extracts 2 times, each 1 hour, filter, filtrate recycling ethanol and to be condensed into relative density be 1.13(75 ℃) clear paste, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 3.5 times, extracts volatile oil 6 hours.The another device of water liquid is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 9 times of volatile oil quality, the water that beta-schardinger dextrin-is added 2.5 times of its quality grinds evenly, then drips volatile oil, then grinds to form pasty state, and inclusion complex grinds 40 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2 times, add the water that decocts 8 times of medicine gross masses at every turn, decocted 1.5 hours at every turn.Filter, filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted the water liquid merging after volatile oil, and being concentrated into relative density is 1.12(65 ℃) concentrated solution, spray drying gets medicated powder standby;
(5) with the beta-cyclo dextrin included compound of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; and the medicated powder that obtains of step (1), the medicated powder that step (2) obtains, the medicated powder that step (4) obtains are merged into mixed powder; add the dextrin of mixed powder weight 28%, the stevioside mix homogeneously of mixed powder weight 0.35%; granulation; dry; the magnesium stearate that adds granulate mixture weight 0.6%, tabletting, and get final product.
The test of pesticide effectiveness:
1. the preparation of alcoholic fatty liver animal model
Get Wistar strain rat, male and female half and half, adaptability is divided into 6 groups after raising for 1 week at random: Normal group, model control group, the embodiment of the present invention 1 medicine group, the embodiment of the present invention 4 medicine groups, the embodiment of the present invention 2 medicine groups, Silybin Capsules matched group.Normal group gives normal diet and water is raised, other groups give the mixed fodder that rat 79.5% Semen Maydis powder, 20% Adeps Sus domestica, 0.5% cholesterol are made, other 30% ethanol is quantitatively drunk and is set up alcoholic fatty liver model (wherein, Normal group is prepared against into the mould detection with model group increase Some Animals).Raise after 30 days, Normal group and model control group are respectively got 10 rat socket of the eye venous blood samplings at random, measure blood inner cholesterol (CHO), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein, LDL (LDL); Live in killing and get rat liver, detect glycogen (Gn), triglyceride (TG) level in liver, carry out histopathologic examination, determine whether to form the alcoholic fatty liver model.After determining to have formed Models of Fatty Liver, gavage is treated administration.
Table 1 rat alcoholic fatty liver model detects
Compare * * * P＜0.001 with Normal group
Table 1 result shows, adds the ethanol stimulation through continuous high fat diet in 30 days, causes metabolism disorder of blood lipid, intrahepatic fat and glycogen to be accumulated.General pathology inspection model control rats liver color jaundice, full, peplos is nervous, greasy sensation is arranged, and it is sharp keen that the edge is owed.The visible hepatocyte obvious tumefaction of tissue pathology checking, the endochylema sky is bright, is lobulated; Thickening of nuclear membrane, sinus hepaticus disappears.The portal area blood vessel is squeezed, and tube chamber diminishes, and a small amount of fibrous connective tissue hypertrophy is arranged, and shows obvious steatosis to occur.Compare with Normal group, model group CHO, TG, LDL, TG, Gn level increase, and the HDL level reduces, and extremely significant difference (P＜0.001) is all arranged, prompting modeling success.
2. treatment administration
After modeling success, each organizes rat still as front method is fed, and by following method administration: 1. rats in normal control group press 10mL/kg volume gavage feed water every day, totally 30 days.2. the model group rat is pressed the feedwater of 10mL/kg volume gavage, totally 30 days every day.3. medicine embodiment of the present invention is 1 group, according to 1.620g/kg body weight (in the crude drug amount) gavage to 1 group of medicine of medicine embodiment of the present invention, totally 30 days.4. medicine embodiment of the present invention is 4 groups, according to 1.620g/kg body weight (in the crude drug amount) gavage to 4 groups of medicines of medicine embodiment of the present invention, totally 30 days.5. medicine embodiment of the present invention is 2 groups, according to 1.620g/kg body weight (in the crude drug amount) gavage to 2 groups of medicines of medicine embodiment of the present invention, totally 30 days.6. positive control medicine group (Silybin Capsules group), according to 12.6mg/kg body weight gavage to Silybin Capsules, totally 30 days.After last treatment administration, rat fasting 12 hours is got blood from portal vein, and 2500rpm low-temperature centrifugation 15min gets serum, adopts automatic clinical chemistry analyzer to measure CHO, TG, HDL, LDL in blood; Take out rapidly liver, electronic balance takes liver weight, calculates liver/body ratio.Make 10% liver tissue homogenate in frozen water, get supernatant after high speed centrifugation, measure Gn, TG, Serum LPO Levels (MDA) and glutathione oxidase (GSH) in liver.Separately get the hepatic tissue blocking of 1cm * 1cm * 1cm, dehydration step by step, transparent, soak cured, embedding, section, dyeing, observe the tissue morphology of liver under light microscopic.
3. result of the test
3.1 ordinary circumstance is observed: alcoholic liver modeling rat reaction compared with normal matched group is blunt, and appetite reduces, and the hair color jaundice occurs glossyly, and happiness flocks together, lazy move and food ration reduces gradually.After gastric infusion, the embodiment of the present invention 1,4, the 2 rear hair colors of medicine group treatment recover normally gradually, and appetite increases, and behavioral activity increases.
3.2 respectively organize the comparison of experimental rat liver regulating liver-QI/body ratio
Rat liver weight respectively organized by table 2 and the liver index compares
Compare ###P＜0.001, ##P＜0.01, #P＜0.05 with model control group
By as seen from Table 2, after rat oral gavage gives ethanol and high lipid food, liver weight regulating liver-QI/body ratio all significantly raises, and after giving the embodiment of the present invention 1,4,2 medicine groups treatments, liver weight regulating liver-QI/body ratio reduces.Statistical procedures shows, compare with model control group, medicine group liver weight numerical value of the present invention has extremely significant difference (P＜0.001), medicine embodiment 1 of the present invention, 4 groups of liver/body ratios have significant differences (P＜0.01), and 2 groups of livers of medicine embodiment of the present invention/body ratio has significant difference (P＜0.05).
3.3 respectively organize the variation of experimental rat change of serum C HO, TG, HDL and LDL
After drug treatment, each group the results are shown in Table 3 and table 4.
Rat blood serum CHO respectively organized by table 3 and the TG level compares
Compare ###P＜0.001 with model control group
Table 4 is respectively organized rat blood serum HDL, LDL level relatively
With model control group ratio, ###P＜0.001, ##P＜0.01, #P＜0.05
By as seen from Table 3, rat oral gavage gives after ethanol and high lipid food that in blood, CHO, TG numerical value all significantly raise, and after giving the embodiment of the present invention 1,4,2 medicine groups treatments, CHO, TG numerical value reduce.Statistical procedures shows, compares with model control group, and in the embodiment of the present invention 1,4,2 medicine group blood, CHO, TG numerical value have extremely significant difference (P＜0.001).
By as seen from Table 4, rat oral gavage gives after high lipid food that in blood, HDL numerical value significantly reduces, and after giving embodiment of the present invention medicine 1,4,2 groups of treatments, HDL numerical value raises.Statistical procedures shows, each is organized HDL numerical value and compares with model control group, and 1 group of medicine of the present invention has extremely significant difference (P＜0.001), 4 groups have significant differences (P＜0.01), 2 groups that significant differences (P＜0.01) is arranged.Rat oral gavage gives after high lipid food that in blood, LDL numerical value significantly raises, and after giving the embodiment of the present invention 1,4,2 medicine groups treatments, LDL numerical value reduces.Statistical procedures shows, compares with model control group, and medicine 1 of the present invention, 4,2 groups of LDL numerical value have extremely significant difference (P＜0.001).
3.4 respectively organize the variation of TG, Gn, MDA, GSH in the experimental rat liver
After drug treatment, each group the results are shown in Table 5 and table 6.
Table 5 is respectively organized Gn in rats'liver, TG level relatively
With model control group ratio, ###P＜0.001, ##P＜0.01
Table 6 is respectively organized MDA in rats'liver, GSH level relatively
With model control group ratio, ###P＜0.001, ##P＜0.01, #P＜0.05
By as seen from Table 5, rat oral gavage gives after high lipid food that in liver, Gn, TG numerical value all significantly raise, and after giving the embodiment of the present invention 1,4,2 medicine groups treatments, Gn, TG numerical value reduce.Statistical procedures shows, compare with model control group, in the embodiment of the present invention 1,4,2 medicine group livers, Gn numerical value all has extremely significant difference (P＜0.001), in the embodiment of the present invention 1,4 medicine group livers, TG numerical value all has extremely significant difference (P＜0.001), and the embodiment of the present invention 2 medicine groups have significant differences (P＜0.01).
By as seen from Table 6, rat oral gavage gives after high lipid food that in liver, MDA numerical value significantly raises, and GSH significantly reduces.Statistical procedures shows, compares with model control group, and in the embodiment of the present invention 1,4,2 medicine group livers, the MDA level has extremely significant difference (P＜0.001); Compare with model control group, in the embodiment of the present invention 1,4 medicine group livers, GSH numerical value has significant differences (P＜0.01), and the embodiment of the present invention 2 medicine groups have significant difference (P＜0.05).
3.5 liver morphology and sections observation
Perusal, rats in normal control group liver color is ruddy, smooth surface, clear-cut margin, peplos is complete, and quality is soft.Model group rat liver color is crineous, liver enlargement, and peplos is nervous, is dispersed in distribution fat and drips, surface uniform distributed granule shape projection.After the embodiment of the present invention 1,4,2 medicine group treatments, rat liver is brown, and liver size and quality are obviously improved than model group, is dispersed in a small amount of fat that distributes and drips.Silybin Capsules matched group liver color and luster is ruddy, and Liver on Judge Hardness improves than model group, is dispersed in the white fat that distributes and drips, surface uniform distributed granule shape projection.
Pathology section examination, rats in normal control group hepatic tissue structure is normal, and sinus hepaticus is high-visible, liver rope marshalling, the fat-free degeneration of hepatocyte, cellularity is clear, and Cytoplasm is abundant, and nucleus is positioned at cell central authorities.The model group rat liver has steatosis in various degree, the endochylema ghost, visible a large amount of fat drip, take nearly peplos place for obviously, along the distribution of lobule central area, the visible little focal necrosis in subregion and cell infiltration.The embodiment of the present invention 1,4,2 medicine groups obviously reduce than model group steatosis cell, and fat drips minimizing; Silybin Capsules matched group hepatocyte form and boundary clear, but the steatosis cell of visible a greater number, fat drips less, big or small homogeneous.
Experimental result demonstrates medicine of the present invention abnormal morphology and the behavioral indicator of alcoholic fatty liver in rats model is had a better role, can reduce TG, Gn, MDA numerical value in rat model CHO, TG, LDL, liver, increase serum hdl and GSH level, improve the rat liver steatosis, regulate the lipid metabolism of alcoholic fatty liver animal model; Histopathology proved invention medicine can alleviate liver cell lesion.In a word, medicine of the present invention can improve liver function, effectively treats alcoholic fatty liver.
Claims (10)
1. Chinese medicine of preventing and treating alcoholic liver injury, it is characterized in that, its raw material medicines in portions by weight ratio consists of: 10～30 parts of Flos puerariae lobataes, 15～45 parts of Semen Hoveniae (Fructus Hoveniae)s, 20～45 parts, Poria, 15～40 parts of the Rhizoma Atractylodis Macrocephalaes, 15～35 parts of Rhizoma Dioscoreaes, 8～30 parts of Fructus Crataegis, 20～45 parts of Radix Salviae Miltiorrhizaes, 15～45 parts of the Radix Paeoniae Albas, 20～45 parts of Herba Artemisiae Scopariaes, 20～45 parts of Semen Cassiaes, 6～20 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine of preventing and treating alcoholic liver injury according to claim 1, it is characterized in that, its raw material medicines in portions by weight ratio consists of: 15～25 parts of Flos puerariae lobataes, 20～40 parts of Semen Hoveniae (Fructus Hoveniae)s, 25～40 parts, Poria, 20～35 parts of the Rhizoma Atractylodis Macrocephalaes, 20～30 parts of Rhizoma Dioscoreaes, 10～22 parts of Fructus Crataegis, 25～40 parts of Radix Salviae Miltiorrhizaes, 20～40 parts of the Radix Paeoniae Albas, 25～40 parts of Herba Artemisiae Scopariaes, 25～40 parts of Semen Cassiaes, 8～15 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine of preventing and treating alcoholic liver injury according to claim 2, it is characterized in that, its raw material medicines in portions by weight ratio consists of: 18～22 parts of Flos puerariae lobataes, 22～35 parts of Semen Hoveniae (Fructus Hoveniae)s, 28～35 parts, Poria, 25～30 parts of the Rhizoma Atractylodis Macrocephalaes, 22～28 parts of Rhizoma Dioscoreaes, 12～15 parts of Fructus Crataegis, 28～35 parts of Radix Salviae Miltiorrhizaes, 25～35 parts of the Radix Paeoniae Albas, 28～35 parts of Herba Artemisiae Scopariaes, 28～35 parts of Semen Cassiaes, 9～12 parts, Radix Glycyrrhizae.
4. according to claim 1,2 or 3 described a kind of Chinese medicines of preventing and treating alcoholic liver injury, is characterized in that, Fructus Crataegi is Fructus Crataegi (parched); Semen Cassiae is Semen Cassiae (parched); The Rhizoma Atractylodis Macrocephalae is Rhizoma Atractylodis Macrocephalae (parched with bran).
5. claim 1,2 or 3 described a kind of preparation methoies of preventing and treating the Chinese medicine of alcoholic liver injury, is characterized in that, comprises the steps:
(1) Poria, Rhizoma Dioscoreae, Fructus Crataegi powder were broken into the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae are adopted ethanol extraction, filter, filtrate recycling ethanol and the clear paste of 1.10-1.15 when being condensed into relative density and being 60-75 ℃, spray drying gets medicated powder standby;
(3) Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are added water distillation and extraction volatile oil, with the cyclic dextrin clathrate of volatile oil with 6-12 times of volatile oil quality, the cyclodextrin inclusion complex that gets volatile oil is standby, and the another device of water liquid is preserved;
(4) Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water, filter, the water liquid that filtrate and Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae are extracted after volatile oil merges, the concentrated solution of 1.10-1.15 when being concentrated into relative density and being 60-75 ℃, spray drying gets medicated powder standby;
(5) with the cyclodextrin inclusion complex of Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae volatile oil; the medicated powder that step (1) obtains; the medicated powder that step (2) obtains; the medicated powder that step (4) obtains is merged into mixed powder, with diluent adjuvant, tender flavor agent adjuvant mix homogeneously, granulation; dry; the lubricant that adds granulate mixture weight 0.5-0.8%, tabletting, and get final product.
6. a kind of preparation method of preventing and treating the Chinese medicine of alcoholic liver injury according to claim 5, it is characterized in that, the described ethanol volumetric concentration of step (2) is 75%-95%, and the 5-10 that each addition is Radix Salviae Miltiorrhizae, Semen Cassiae gross mass doubly, extract 2-3 time, extracted 1-2 hour at every turn.
7. a kind of preparation method of preventing and treating the Chinese medicine of alcoholic liver injury according to claim 5, is characterized in that, step (3) amount of water is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae gross mass 3-5 times, extracts volatile oil 5-8 hour.
8. a kind of preparation method of preventing and treating the Chinese medicine of alcoholic liver injury according to claim 5, it is characterized in that, the described inclusion of step (3) is ground or is stirred for cyclodextrin being added suitable quantity of water, then drip volatile oil, grind again or stir, inclusion complex grinds 40-50 ℃ of drying, gets the cyclodextrin inclusion complex of volatile oil.
9. a kind of preparation method of preventing and treating the Chinese medicine of alcoholic liver injury according to claim 5, it is characterized in that, step (4) is that the Radix Salviae Miltiorrhizae after the Flos puerariae lobatae after Semen Hoveniae (Fructus Hoveniae), the Radix Paeoniae Alba, Radix Glycyrrhizae and extraction volatile oil, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae residue and ethanol extraction, Semen Cassiae residue are merged, decoct with water 2-3 time, add to decoct medicine gross mass 6-10 water doubly at every turn, decocted 1-2 hour at every turn.
10. a kind of preparation method of preventing and treating the Chinese medicine of alcoholic liver injury according to claim 5, it is characterized in that, step (5) diluent adjuvant addition is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, the cyclodextrin inclusion complex of Herba Artemisiae Scopariae volatile oil, the medicated powder that step (1) obtains, the medicated powder that step (2) obtains, the 25-35% of medicated powder weight after the medicated powder that step (4) obtains mixes, tender flavor agent adjuvant addition is Flos puerariae lobatae, the Rhizoma Atractylodis Macrocephalae, the cyclodextrin inclusion complex of Herba Artemisiae Scopariae volatile oil, the medicated powder that step (1) obtains, the medicated powder that step (2) obtains, the 0.2-0.6% of medicated powder gross weight after the medicated powder that step (4) obtains mixes.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271404A (en) * | 2013-06-18 | 2013-09-04 | 吉林省绳氏堂药业有限公司 | Wine decanting, stomach and liver protecting and hangover-preventing beverage and preparation method thereof |
| CN104644915A (en) * | 2015-01-22 | 2015-05-27 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition |
| CN104862157A (en) * | 2015-04-07 | 2015-08-26 | 无锡丝润生物技术有限公司 | Beer additive for relieving the effect of alcohol and protecting liver and preparation method thereof |
| CN105999212A (en) * | 2016-05-13 | 2016-10-12 | 无限极（中国）有限公司 | Composition having alcohol effect dispelling effect and preparation method and application thereof |
| CN108391813A (en) * | 2018-04-02 | 2018-08-14 | 齐鲁工业大学 | A kind of relieving alcoholism and protecting liver ferment and preparation method thereof |
| CN110025723A (en) * | 2019-05-16 | 2019-07-19 | 江苏千药堂国医研究院有限公司 | A kind of production method and purposes of compound hoveniae semoveniae semen combined extracts |
| CN111956715A (en) * | 2020-07-07 | 2020-11-20 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Medicine for treating alcoholic liver disease and preparation method thereof |
| CN115487280A (en) * | 2022-10-19 | 2022-12-20 | 浙江中医药大学 | Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070825A (en) * | 1992-06-23 | 1993-04-14 | 余朋千 | The prescription of anti-intoxication alcohol neutralizing oral agents and manufacture method |
-
2013
- 2013-03-29 CN CN201310108421.1A patent/CN103142812B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070825A (en) * | 1992-06-23 | 1993-04-14 | 余朋千 | The prescription of anti-intoxication alcohol neutralizing oral agents and manufacture method |
Non-Patent Citations (2)
| Title |
|---|
| 殷晓轩等: "酒精性肝病中医用药规律探讨", 《中国实验方剂学杂志》 * |
| 高舒迪等: "中医药治疗酒精性肝病的辨病论治概况及研究述评", 《西部中医药》 * |
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| CN103271404B (en) * | 2013-06-18 | 2014-10-22 | 吉林省绳氏堂药业有限公司 | Wine decanting, stomach and liver protecting and hangover-preventing beverage and preparation method thereof |
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| CN108391813A (en) * | 2018-04-02 | 2018-08-14 | 齐鲁工业大学 | A kind of relieving alcoholism and protecting liver ferment and preparation method thereof |
| CN110025723A (en) * | 2019-05-16 | 2019-07-19 | 江苏千药堂国医研究院有限公司 | A kind of production method and purposes of compound hoveniae semoveniae semen combined extracts |
| CN111956715A (en) * | 2020-07-07 | 2020-11-20 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Medicine for treating alcoholic liver disease and preparation method thereof |
| CN115487280A (en) * | 2022-10-19 | 2022-12-20 | 浙江中医药大学 | Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof |
| CN115487280B (en) * | 2022-10-19 | 2023-12-19 | 浙江中医药大学 | Traditional Chinese medicine composition for dispelling effects of alcohol, protecting liver and promoting liver regeneration as well as preparation and preparation method thereof |
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