CN102698206B - Chinese medicine for treating nonalcoholic fatty liver and preparation method thereof - Google Patents
Chinese medicine for treating nonalcoholic fatty liver and preparation method thereof Download PDFInfo
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Abstract
The invention relates to Chinese medicine for treating nonalcoholic fatty liver and a preparation method thereof. The Chinese medicine consists of the following Chinese medicinal raw materials in parts by weight: 6-20 parts of green tangerine peel, 6-20 parts of turmeric root-tuber, 8-25 parts of large-head atractylodes rhizome, 10-30 parts of Chinese yam, 9-25 parts of indian buead, 9-25 parts of oriental waterplantain rhizome, 9-25 parts of cassia seed, 9-25 parts of fructus crataegi, 9-25 parts of red-rooted salvia root and 6-20 parts of safflower. The method comprises the following steps of: graining the Chinese yam and indian buead into fine powder; adding water into green tangerine peel, turmeric root-tuber and large-head atractylodes rhizome for distilling and extracting volatile oil, and including the volatile oil with beta-cyclodextrin; extracting red-rooted salvia root, cassia seed and fructus crataegi by using ethanol, and concentrating into clear paste; mixing dregs left after extraction of volatile oil and dregs left after extraction of ethanol with medicaments such as saffron, oriental waterplantain rhizome and the like, decocting with water, precipitating with alcohol, and concentrating into clear paste; and combining the clear paste, granulating into particles together with the Chinese yam and indian buead fine powder, uniformly mixing the particles with a beta-cyclodextrin inclusion complex of volatile oil, adding a lubricating agent, tableting and coating. Theses medicaments are combined comprehensively. The Chinese medicine has the effects of soothing the liver, invigorating the spleen, removing dampness through diuresis and invigorating blood circulation, and is a good medicament for treating nonalcoholic fatty liver.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease and preparation method thereof.
Background technology
Fatty liver (fatty liver, FL) be clinical common disease, along with the change of people life style and the variation of dietary structure, the sickness rate of fatty liver constantly rises, and has become the second largest hepatopathy that is only second to viral hepatitis in some developed areas of China.Non-alcoholic fatty liver disease (NAFLD) is a kind of without excessive history of drinking history, take hepatic cell fattydegeneration and fatty clinical pathology syndrome of storing up as feature.Bibliographical information, adult's sickness rate is about 10%～24%, and the overweight people can be up to 57%～74%.Wherein 5%～15% patient has the potential danger that develops into liver cirrhosis.Non-alcohol fatty liver is one of important public health problem in the 21 century whole world, also is the more and more important chronic hepatopathy problem of China.
Non-alcoholic fatty liver disease belongs to the categories such as the traditional Chinese medical science " hypochondriac pain ", " stasis of liver-Q and liver-blood ", " gathering ", " feeling of fullness ", " turbid ", and the earliest record sees Difficult Classic: " liver is long-pending, and name is said lump at the left hypochondrium "; "guide to clinical practice with medical record" has elaborations such as " and but wet from interior survivor, must its people's fat meat and fine grain wine sweet wine excessive ", recognizes that primary disease is with damp and hot relevant; In " at all times doctor mirror " " hypochondriac pain person ... touch if hinder because of rage, grieved depressed, surfeit cold and hot imbalance ... or the accumulation of phlegm multiple abscess fights with blood mutually in blood, all can be pain " discussion, disclose primary disease and expectorant blood stasis and have the pass.Chinese medicine thinks, the origin cause of formation of primary disease mostly is surfeit delicious food, obesity, disorder of emotion and causes the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, and damp and hot interior life, the turbid pent-up of expectorant, stagnation of blood stasis causes humidity hysteresis stagnation of phlegm stasis eventually, numbness resistance liver venation and form non-alcoholic fatty liver disease.Disorder of QI and blood, the wet stasis of blood is tied mutually, simulataneous insufficiency and excessive is the primary disease pathogenic characteristic.Therefore, harmonizing the liver and spleen, damp eliminating blood stasis dispelling are the basic therapies for the treatment of fatty liver.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease and preparation method thereof, this kind Chinese medicine energy soothing liver and strengthening spleen, dampness removing is invigorated blood circulation, taking convenience, good drug efficacy, and preparation technology is reasonable.
The technical scheme that the present invention takes is:
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, its weight part ratio consists of: 6～20 parts on Pericarpium Citri Reticulatae Viride, 6～20 parts of Radix Curcumaes, 8～25 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Rhizoma Dioscoreaes, 9～25 parts in Poria, 9～25 parts of Rhizoma Alismatis, 9～25 parts of Semen Cassiaes, 9～25 parts of Fructus Crataegis, 9～25 parts of Radix Salviae Miltiorrhizaes, 6～20 parts on Flos Carthami.
The Chinese medicine of above-mentioned treatment non-alcoholic fatty liver disease, preferred weight part ratio consists of: 8～15 parts on Pericarpium Citri Reticulatae Viride, 8～15 parts of Radix Curcumaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 12～25 parts of Rhizoma Dioscoreaes, 10～20 parts in Poria, 10～20 parts of Rhizoma Alismatis, 10～20 parts of Semen Cassiaes, 10～20 parts of Fructus Crataegis, 10～20 parts of Radix Salviae Miltiorrhizaes, 8～15 parts on Flos Carthami.
The Chinese medicine of above-mentioned treatment non-alcoholic fatty liver disease, further preferred weight part ratio consists of: 9～12 parts on Pericarpium Citri Reticulatae Viride, 9～12 parts of Radix Curcumaes, 12～15 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Rhizoma Dioscoreaes, 12～18 parts in Poria, 12～18 parts of Rhizoma Alismatis, 12～18 parts of Semen Cassiaes, 12～18 parts of Fructus Crataegis, 12～18 parts of Radix Salviae Miltiorrhizaes, 9～12 parts on Flos Carthami.
In the above-mentioned Chinese medicine, the preferred stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of Pericarpium Citri Reticulatae Viride wherein; The preferred Semen Cassiae (parched) of Semen Cassiae; Rhizoma Alismatis preferred salt Rhizoma Alismatis; The preferred Rhizoma Atractylodis Macrocephalae (parched with bran) of the Rhizoma Atractylodis Macrocephalae; The preferred Fructus Crataegi (parched) of Fructus Crataegi.
The preparation method of the Chinese medicine of above-mentioned treatment non-alcoholic fatty liver disease comprises the steps:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted ethanol extraction, filter, filtrate recycling ethanol and to be condensed into relative density be 1.10-1.25(50-80 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, with the beta-schardinger dextrin-inclusion of volatile oil with 5-12 times of volatile oil quality, the beta-cyclo dextrin included compound that gets volatile oil is for subsequent use, and water liquid in addition device is preserved;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.05-1.15(50-80 ℃) concentrated solution;
(5) concentrated solution of step (4) is added ethanol and stirs, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.10-1.25(50-80 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the lubricant of granulate mixture weight 0.5-0.8%, tabletting, film coating.
The described concentration of alcohol of above-mentioned steps (2) is 75%-95%(v/v), the 4-12 that each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass doubly extracts 2-3 time, extracts 1-2 hour at every turn.
Above-mentioned step (3) amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 3-6 times, extracts volatile oil 4-10 hour.
The described inclusion of above-mentioned step (3) is ground or is stirred for beta-schardinger dextrin-being added suitable quantity of water, then drips volatile oil, grinds or stirs, and inclusion complex grinds 40-50 ℃ of drying, gets the beta-cyclo dextrin included compound of volatile oil.
Above-mentioned steps (4) is that the Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2-3 time, decoct medicine gross mass 5-12 water doubly each the adding, decocted 1-2 hour at every turn.
Above-mentioned steps (5) is 95%(v/v for the concentrated solution of step (4) is added concentration) alcoholic solution stir, add 95%(v/v) amount of alcohol be step (4) concentrated solution quality 1-2 doubly, staticly settle and filter.
Above-mentioned steps (7) with lubricator, coating material is the adjuvant of pharmaceutically knowing altogether.
Pericarpium Citri Reticulatae Viride is the dry young fruit of rutaceae orange Citrus reticulate Blanco and variety thereof and the peel of immature fruit among the side of the present invention.Has depressed liver-energy dispersing and QI regulating, the function that removing food stagnancyization stagnates.Be used for sternal rib pain, stagnation of QI due to dyspepsia, abdominal distention etc." Bencao Tujing ": " bitter in the mouth.The main stagnation of QI, lower food, removing mass knot and diaphragm gas." " medicine origin ": " and " cure mainly secret want " cloud: bitter in the mouth cold in nature, abnormal smells from the patient are all thick, and be heavy and fall, the moon also, it is with having five: foot is fainted dividing of the moon, few sun, illly then uses it, one also.Broken hard addiction two also.Loose stagnant gas three also.Remove the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels all wet four also.Control left rib and pneumatosis five is arranged also." Compendium of Material Medica: " control the chest and diaphragm QI rising in reverse order, costalgia, lower abdomen colic, the swelling of the breast that disappears, soothing the liver gallbladder, eliminating the pathogens from the lung gas." " book on Chinese herbal medicine converges and says ": " blue or green Pericarpium Citri tangerinae breaks the gas that stagnates, cuts hard long-pending medicine also.”
Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Function cures mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.Be used for the costa sternales twinge, obstruction of qi in the chest and cardialgia etc." Newly Revised Canon of Materia Medica ": " main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound." Compendium of Material Medica: " Radix Curcumae enters the heart and envelope.Control the vim and vigour cardiac and abdominal pain, puerperal, alienation caused by lochioschesis was wanted extremely, and it is demented to lose the heart." " Thunder God concoct the property of medicine solution ": " and enter the heart, lung two warps, husband's lung governing qi, heart master blood, Radix Curcumae can qi and blood circulation promotion, so two people it." " book on Chinese herbal medicine is just ": " and alone married woman's cold air accumulation of blood of controlling, the knot gather qi together stagnates, and the trusted subordinate has a pain." essentials of Matea Medica: " circulation of qi promoting, resolving depression are let out blood, removing blood stasis with potent drugs, cool heat in the heart, loose stagnation of liver-QI.Controlling married woman's passages through which vital energy circulates drives in the wrong direction." and Pericarpium Citri Reticulatae Viride compatibility depressed liver-energy dispersing and QI regulating.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic.Shennong's Herbal: " the hidroschesis heat extraction helps digestion for the dead flesh of main anemofrigid-damp arthralgia, convulsion, subcutaneous ulcer." " Mingyi Bielu ": " and expectorant water, it is swollen to allowance for bark an edema due to wind pathogen knot, and the warming the stomach rapid digestion of food is had a liking for food." " property of medicine book on Chinese herbal medicine ": " control the insufficiency of stomach diarrhea." " all book on Chinese herbal medicine of solar corona ": " diuresis." " pearl sac ": " and expectorant is relieved oedema or abdominal distension through diuresis or purgation for dehumidifying QI invigorating, invigorating middle warmer YANG invigorating, promoting the production of body fluid to quench thirst, and antidiarrheal dysentery, sufficient shin damp-edema disappears " and " property of medicine opinion ": " swelling of harnessing the river is full, and preventing or arresting vomiting is contrary, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI." " medicine origin ": " and the Rhizoma Atractylodis Macrocephalae, the benefit that can dehumidify is dry, and middle QI invigorating, and blood between sharp waist umbilicus is except pathogenic heat in the stomach." " book on Chinese herbal medicine converge with speech ": " and the Rhizoma Atractylodis Macrocephalae is to foster taste, the wet dissipation eliminating impediment, help digestion except the key medicine of painful abdominal mass also.”
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Shennong's Herbal: " main damaging the spleen and stomach, tonify deficiency is won, except the cold and heat pathogen, invigorating middle warmer, physical strength profiting, longue meat, reinforcing YIN-essence." " all book on Chinese herbal medicine of solar corona ": " kidney tonifying gas, strengthening the spleen and stomach, antidiarrheal dysentery, the saliva that reduces phlegm, profit fur." " Mingyi Bielu ": " and main women's head-ornaments urticaria, public attention eye is dizzy, and the therapeutic method to keep the adverse QI flowing downwards is ended pain in the lumbar region, and tonify deficiency labor is won thin, fills the five internal organs, heat clearing away and restlessness relieving, reinforcing YIN-essence." " property of medicine opinion ": " mend five kinds of strain and seven kinds of impairment, remove cold wind, end lumbago, relieving palpitation is refreshing, and the reinforcing the heart QI-insufficiency suffers from that human body is empty wins, and adds and uses it." " Japan hanako materia medica ": " and help the five internal organs, bone and muscle strengthening, long will is calmed the nerves, and the main essence of letting out is forgetful." Compendium of Material Medica: " kidney tonifying gas, strengthening the spleen and stomach, antidiarrheal dysentery, the saliva that reduces phlegm, profit fur.”
Poria is the dry sclerotia of On Polyporaceae Poria.The function promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, malaise, palpitation with fear insomnia.Shennong's Herbal: " the contrary gas of main costa sternales .... diuresis, clothes peace soul is reposed for a long time." " Mingyi Bielu ": " and large abdomen is dripping, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot .... cut down the Kidney heresy." Materia Medica of Decoction: " rush down bladder, strengthening the spleen stomach ， Zhi Kidney amasss renal mass." Compendium of Material Medica: " Cortex Sclerotii Poriae master edema general edema, dredging water passages, loosing the interspaces of skin and muscles." " property of medicine opinion ": " can whet the appetite, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria.Red person breaks stagnation of QI." " medicine origin ": " and only quench one's thirst, diuresis, the dehumidifying benefit is dry, blood between sharp waist umbilicus, and middle QI invigorating is main.Control urinary obstruction, it is yellow or red and unfavorable to drown." " medication heart method ": " the sharp key of the light energy of Poria, sweet with supporing yang, the panacea of dehumidifying is also.Sweet in the mouth is flat, YANG invigorating, and strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation ... the slow spleen of harnessing the river, the inducing QI of promoting the production of body fluid." " Sheng Nong's herbal classic dredge ": " and the white person of Poria enters edema caused by disorder of QI, and red person enters blood system, the reinforcing the heart strengthening the spleen, be better than in vain red, the tonneau small intestinal, specially except damp and hot, red also win white." " herbal classic is met former ": " the stool person of rushing down, disorder of stomach-QI can not divide diuretic paddy, partially ooze large intestine and rush down notes also, and Poria divides sharp negative and positive, then rush down from ending also." " generation mend vegetarian medical book ": " Poria simply, for controlling the expectorant principal agent.Expectorant is basis, and water also.Poria can be gone water; Expectorant is moving, wets also, and Poria can be gone again wet.”
Rhizoma Alismatis is Notes On Alism At Aceae Rhizoma Alismatis dry rhizome.The function promoting diuresis to eliminate damp pathogen expels the heat-evil, and changes turbid blood fat reducing.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.Shennong's Herbal; " main anemofrigid-damp arthralgia, breast is difficult, supports the five internal organs, physical strength profiting, the fertile strong water that disappears." " Mingyi Bielu ": " control and quench one's thirst drippingly, cut off the water by bladder, three warmers." " property of medicine book on Chinese herbal medicine ": " control five types of stranguria, promoting diuresis by dispersing lung-QI." " pearl sac ": " and enter kidney channel ... the .. diuresis, detumescence is swollen." Compendium of Material Medica: " Rhizoma Alismatis gas is flat, and sweet in the mouth is and light, and light can oozing let out, and abnormal smells from the patient is all thin, so diuretic and diarrhea." property of medicine opinion ": " the main essence of suffering from a deficiency of the kidney is controlled five types of stranguria from going out, sharp bladder heat, promoting diuresis by dispersing lung-QI." " Japan hanako materia medica ": " and control five kinds of strain and seven kinds of impairment, main head revolves the ear tinnitus of deficiency type, the muscles and bones contracture, and logical small intestinal is only lost drop, and hematuria expedites the emergence of difficult labour, mends woman's sea of blood, has made us son." " book on Chinese herbal medicine converges and says ": " Rhizoma Alismatis, the principal agent of diuretic.Diuretic, the people all knows, and Dan Xi calls again can sharp bladder, the fire of envelope, and the bladder envelope has fire, the swollen person of sick difficulty in urination knot, fire rushes down that then water is capable, and row water then fire falls, and the extreme misery ambiguous is not mutually exclusive." " medicineization justice ": " and all genus rush down disease, and little water must short number, with this (Rhizoma Alismatis) clear and rich lung qi, and regulating fluid apssage, lower defeated bladder cures mainly the watery diarrhea dairrhea caused by pathogenic damp, makes and defecates real, and then temper is from being good for also.Because of the ability water channel, make evil water go, then true water must be supported, and can end so quench one's thirst.”
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.The function clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, constipation." property of medicine book on Chinese herbal medicine ": " treating the liver hot blast eye red tear." " book on Chinese herbal medicine is looked for the truth ": " except the wind heat radiation.Ordinary person's order tear is not received, and ophthalmalgia is more than, belongs to excessive in the wind heat more ... so. tear pain relieving key medicine received for controlling order." " Mingyi Bielu ": " treat blue-purple lips." " Treatise on Dietetic Therapy ": " main liver man pyretic toxicity gas, the red tear of wind-eye.”
Fructus Crataegi is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.The function promoting digestion and invigorating the stomach, the circulation of qi promoting dissipating blood stasis is changed turbid blood fat reducing.Be used for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipidemia." daily book on Chinese herbal medicine ": " inguinal hernia is controlled in the long-pending spleen reinforcing that helps digestion, and sends out children's's skin ulcer rash." " Amplification on Materia Medica addendum ": " stomach invigorating row stagnation of QI is controlled married woman's after-pains in puerperal, lochiorrhea." Compendium of Material Medica: " dissipating fluid-retention food, the Rou Ji mass in the abdomen that disappears, phlegm retention feeling of fullness, the acid regurgitation blood pain with distension that stagnates." " occupying the diet spectrum with breath ": " and the gas of being amusing, the meat that disappears, broken congestion, mass dissipating and swelling eliminating relieves the effect of alcohol and reduces phlegm, except infantile malnutrition, antidiarrheal dysentery." " in the inner feelings ginseng west record ": " the Fructus Crataegi flavor is little sweet to acid, and property is flat, and the red flesh-coloured Huang of skin so to be apt to into blood system be the key medicine of Removing Blood Stasis, can remove Xuan Pi mass in the abdomen, and the woman closes the moon, and postnatal blood stasis aches.Little sweet for its sour in the mouth, can subsidize gastric acid juice, gather so can digest diet, to control the long-pending outstanding effect of meat.If help it with sweet medicine, Removing Blood Stasis and do not hinder fresh blood, dissipating depression of QI gas and do not hinder healthy energy, the outstanding peace of its property is also." " book on Chinese herbal medicine is looked for the truth ": " Fructus Crataegi, so-called spleen invigorating person because its spleen has food stagnation, think wear down that with the salty flavor of this acid expectorant disappears in order to do the food row, and broken and the letting out of gas is clear for strong, only belongs to the strong of food stagnation removing." " variola does not rise, and power can be to send out; Still see the meaning of logical stasis of blood transporting." Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Semen Cassiae, Fructus Crataegi play spleen invigorating, dampness removing altogether, it is turbid to let out.
Radix Salviae Miltiorrhizae is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..The function blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood disappears bitterly.Be used for obstruction of qi in the chest and cardialgia, gastral cavity abdominal rib Tong ， lumps in the chest and abdomen, pyretic arthralgia pain etc.Shennong's Herbal: " main trusted subordinate's pathogen, borborygmus are faint as leaking water, and cold and heat gather ， Po Disorder except abdominal mass, end stuffy sensation with restlessness, QI invigorating." " Mingyi Bielu ": " and nourish blood, go trusted subordinate's obstinate disease, stagnation of QI, back rigidity, foot numbness, exorcising stays heat." " all book on Chinese herbal medicine of solar corona ": " sedate of reposing, tonneau GUAN-pulse are controlled cold and hot labor arthralgia, extremity are unsuccessful, the headache acute conjunctivitis, and the heat temperature is mad vexed, broken stagnated blood, tissue regeneration promoting blood, peaceful tire, the stillborn fetus that falls under the hemostasis metrorrhagia and leukorrhagia, transfers married woman's passages through which vital energy circulates irregular, the blood evil thought is tired, malignant boil Jie Xian, the wart toxic swelling of going to live in the household of one's in-laws on getting married, erysipelas, the evacuation of pus pain relieving, granulation promoting is put on flesh." " property of medicine opinion ": " flat.Can control the painful numbness of flaccidity of the lower limbs, main attacked by pestiferous factors is controlled hundred evil ghosts and goblins' stomachache, and gas is done the sound ring and shouted, can be fixed smart." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." Compendium of Material Medica: " invigorate blood circulation, logical percardium is controlled the xenon pain." " book on Chinese herbal medicine justice ": " Radix Salviae Miltiorrhizae specially enters blood system, and its merit is the promoting the circulation of blood of invigorating blood circulation, and interior reaches internal organs and blood stasis dispelling stagnates, so it is broken to gather Xiao Er mass in the abdomen; Outer profit joint and the network of promoting blood circulation, the then strong and numbness work row of waist knee joint.Auspicious nuclear ancients cure mainly, the effect of the logical operation of none non-a surname, so and its energy operator then must have the gas of gentleness, can agitate it, vibrate it, so-called main trusted subordinate's pathogen borborygmus obstinate disease, its justice is faintly visible.”
Flos Carthami is the dried floral of feverfew Flos Carthami.The function promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stasis of blood stagnates and suffers from abdominal pain, the twinge of the breast side of body, injury from falling down, skin infection swells and ache." Kaibao Bencao " " the puerperal blood faints locked mouth, in the abdomen stagnant blood not to the utmost, angor, retention of dead fetus, and wine boils clothes; Also main diseases due to noxious agents produced by various parasites." Compendium of Material Medica: " invigorate blood circulation and moisturize, pain-relieving powder for treating is swollen, stimulates the menstrual flow." " book on Chinese herbal medicine meets the source ": " and can manage it man's blood vessels, logical married woman invigorates blood circulation through water, separates the pox poison, and is loose red swollen, puerperal blood faints and retention of dead fetus, and should take it with urine of baby boys." " book on Chinese herbal medicine justice ": " and this gentleness of property, gas are held concurrently hot loose, all stasis of bloods inner product that stagnates, and the unfavorable all cards of meridians, and all it is specially led.But walk and do not keep, fast sharp four reach, and agent is solely appointed greatly; Just only think the usefulness that dredging is invigorated blood circulation, little dose also without abuses." " Amplification on Materia Medica addendum ": " Flos Carthami is broken bleeds, and nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood." " book on Chinese herbal medicine converges and says ": " Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood is also." Radix Salviae Miltiorrhizae, Flos Carthami blood circulation promoting and blood stasis dispelling.
The all medicine compatibilities in the full side of the present invention, soothing the liver, spleen invigorating, dampness removing is invigorated blood circulation, and is the good recipe for the treatment of non-alcoholic fatty liver disease.
The characteristics of preparation method of the present invention are the physicochemical properties according to the prescription contained effective ingredient of 10 herbal medicines or main component, with prescription drug be divided into direct pulverizing, ethanol extraction, extraction volatile oil, water decoction-alcohol sedimentation (comprising the medicine carried behind the volatile oil and the medicine behind the ethanol extraction), beta-schardinger dextrin-carries out five parts of inclusion, its extraction and preparation technique is scientific and reasonable.Preparation technology is more traditional, and decocting becomes decoction, has kept to a greater extent effective ingredient, and makes tablet, is suitable for suitability for industrialized production, takes more convenient.□
The medicine of directly pulverizing: Rhizoma Dioscoreae in the side, Poria mealiness are stronger, are easy to pulverize, and therefore directly are ground into fine powder and are used as medicine, and replace adjuvant.
Contain the extraction of volatile oil medicine: to containing medical material Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae of volatile oil in the prescription, for fully keeping its effective ingredient, then extract first volatile oil, water liquid in addition device is collected, and medicinal residues are incorporated in the water decoction-alcohol sedimentation medicine and fry in shallow oil altogether.
Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi in the prescription are at first adopted its effective ingredient of ethanol extraction, and then medicinal residues remerge in the medicine of water decoction-alcohol sedimentation.
The extraction of water decoction-alcohol sedimentation medicine: to containing Radix Salviae Miltiorrhizae, Semen Cassiae, the Fructus Crataegi behind Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae and the ethanol extraction behind medical material Flos Carthami, Rhizoma Alismatis and the extraction volatile oil that aqueous soluble active constituent or water alcohol all is dissolved with the effect composition in the prescription, mix and decoct, filter, concentrated, the ethanol precipitation.
The beta-schardinger dextrin-inclusion of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil: for increasing Pericarpium Citri Reticulatae Viride, Radix Curcumae, the stability of Rhizoma Atractylodis Macrocephalae volatile oil in preparation of extracting, adopt beta-schardinger dextrin-to carry out inclusion it.
Use Chinese medicine of the present invention animal has been carried out pharmacodynamic observation, have preferably curative effect.
The specific embodiment
Further specify below in conjunction with embodiment.
Embodiment 1
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, its weight part ratio consists of: Pericarpium Citri Reticulatae Viride 6g, Radix Curcumae 6g, Rhizoma Atractylodis Macrocephalae 8g, Rhizoma Dioscoreae 10g, Poria 9g, Rhizoma Alismatis 9g, Semen Cassiae 9g, Fructus Crataegi 9g, Radix Salviae Miltiorrhizae 9g, Flos Carthami 6g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 75% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 4 times, extracts each 1 hour 2 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.10(50 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 3 times, extracts volatile oil 4 hours.Water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 5 times of volatile oil quality, the water that beta-schardinger dextrin-is added 2 times of its quality grinds evenly, then drips volatile oil, grinds to form pasty state again, and inclusion complex grinds 40 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2 times, each water that decocts 5 times of medicine gross masses that adds decocted 1 hour at every turn.Filter, filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract the water liquid merging behind the volatile oil, and being concentrated into relative density is 1.05(50 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 1 times (m/m) of step (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.10(50 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.5%, tabletting, film coating.
Embodiment 2
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, its weight ratio consists of: Pericarpium Citri Reticulatae Viride 20g, Radix Curcumae 20g, Rhizoma Atractylodis Macrocephalae 25g, Rhizoma Dioscoreae 30g, Poria 25g, Rhizoma Alismatis 25g, Semen Cassiae 25g, Fructus Crataegi 25g, Radix Salviae Miltiorrhizae 25g, Flos Carthami 20g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 95% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 12 times, extracts each 2 hours 4 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.25(80 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 6 times, extracts volatile oil 10 hours, and water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion (water that beta-schardinger dextrin-added its quality 2.5 times grind evenly, then drip volatile oil, grind to form pasty state again, inclusion complex 50 ℃ dryings grind, get the beta-cyclo dextrin included compound of volatile oil) of volatile oil with 12 times of volatile oil quality;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 3 times, each water that decocts 12 times of medicine gross masses that adds, the each decoction 2 hours, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.15(80 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 2 times (m/m) of step (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.25(80 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.8%, tabletting, film coating.
Embodiment 3
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 8g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Dioscoreae 12g, Poria 10g, Rhizoma Alismatis 10g, Semen Cassiae 10g, Fructus Crataegi 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 8g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 80% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 6 times, extracts each 1 hour 2 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.15(60 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 4 times, extracts volatile oil 6 hours, and water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion (water that beta-schardinger dextrin-added its quality 2 times stir, then drip volatile oil, restir become pasty state, inclusion complex 45 ℃ dryings grind, get the beta-cyclo dextrin included compound of volatile oil) of volatile oil with 8 times of volatile oil quality;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2 times, each water that decocts 6 times of medicine gross masses that adds, the each decoction 1.5 hours, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.08(65 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 1.5 times (m/m) of step (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.20(70 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.6%, tabletting, film coating.
Embodiment 4
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 15g, Radix Curcumae 15g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 25g, Poria 20g, Rhizoma Alismatis 20g, Semen Cassiae 20g, Fructus Crataegi 20g, Radix Salviae Miltiorrhizae 20g, Flos Carthami 15g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 85% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 8 times, extracts each 1.5 hours 3 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.20(70 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 5 times, extracts volatile oil 8 hours, and water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion (water that beta-schardinger dextrin-added its quality 2.5 times stir, then drip volatile oil, restir become pasty state, inclusion complex 45 ℃ dryings grind, get the beta-cyclo dextrin included compound of volatile oil) of volatile oil with 9 times of volatile oil quality;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2 times, each water that decocts 8 times of medicine gross masses that adds, the each decoction 2 hours, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.10(70 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 1.5 times (m/m) of (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.20(70 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.8%, tabletting, film coating.
Embodiment 5
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 9g, Radix Curcumae 9g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Dioscoreae 15g, Poria 12g, Rhizoma Alismatis 12g, Semen Cassiae 12g, Fructus Crataegi 12g, Radix Salviae Miltiorrhizae 12g, Flos Carthami 9g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 80% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 6 times, extracts each 1.5 hours 2 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.15(65 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 4 times, extracts volatile oil 6 hours, and water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion (water that beta-schardinger dextrin-added its quality 2 times grind evenly, then drip volatile oil, grind to form pasty state again, inclusion complex 45 ℃ dryings grind, get the beta-cyclo dextrin included compound of volatile oil) of volatile oil with 9 times of volatile oil quality;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2 times, each water that decocts 6 times of medicine gross masses that adds, the each decoction 1.5 hours, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.12(65 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 1.5 times (m/m) of step (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.18(60 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.5%, tabletting, film coating.
Embodiment 6
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 12g, Radix Curcumae 12g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 20g, Poria 18g, Rhizoma Alismatis 18g, Semen Cassiae 18g, Fructus Crataegi 18g, Radix Salviae Miltiorrhizae 18g, Flos Carthami 12g.
Preparation method is:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted 90% ethanol (V/V) extract, each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass 8 times, extracts each 2 hours 3 times, filter, filtrate recycling ethanol and to be condensed into relative density be 1.20(75 ℃) clear paste for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 4 times, extracts volatile oil 8 hours.Water liquid in addition device is preserved; With the beta-schardinger dextrin-inclusion of volatile oil with 10 times of volatile oil quality, the water that beta-schardinger dextrin-is added 2.5 times of its quality grinds evenly, then drips volatile oil, grinds to form pasty state again, and inclusion complex grinds 45 ℃ of dryings, gets the beta-cyclo dextrin included compound of volatile oil;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2 times, each water that decocts 10 times of medicine gross masses that adds, the each decoction 2 hours, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, and being concentrated into relative density is 1.15(65 ℃) concentrated solution;
(5) concentrated solution with step (4) adds 95% ethanol (V/V) stirring, adding 95%(v/v) amount of ethanol is 2 times (m/m) of step (4) concentrated solution quality, staticly settle and filter, filtrate recycling ethanol and to be condensed into relative density be 1.20(70 ℃) clear paste for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the magnesium stearate of granulate mixture weight 0.7%, tabletting, film coating.
Embodiment 7
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Dioscoreae 15g, Poria 15g, Rhizoma Alismatis 15g, Semen Cassiae 15g, Fructus Crataegi 15g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 10g.
Preparation method is embodiment 1 simultaneously.
Embodiment 8
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 20g, Poria 15g, Rhizoma Alismatis 12g, Semen Cassiae 12g, Fructus Crataegi 15g, Radix Salviae Miltiorrhizae 18g, Flos Carthami 9g.
Preparation method is embodiment 2 simultaneously.
Embodiment 9
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 13g, Rhizoma Dioscoreae 18g, Poria 14g, Rhizoma Alismatis 13g, Semen Cassiae 13g, Fructus Crataegi 13g, Radix Salviae Miltiorrhizae 13g, Flos Carthami 11g.
Preparation method is embodiment 5 simultaneously.
Embodiment 10
A kind of Chinese medicine for the treatment of non-alcoholic fatty liver disease, it consists of: Pericarpium Citri Reticulatae Viride 11g, Radix Curcumae 11g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Dioscoreae 19g, Poria 15g, Rhizoma Alismatis 14g, Semen Cassiae 13g, Fructus Crataegi 13g, Radix Salviae Miltiorrhizae 16g, Flos Carthami 10g.
Preparation method is embodiment 6 simultaneously.
Zoopery
1. the preparation of the high fat diet non-alcoholic fatty liver disease animal model of inducing
Get Wistar strain rat, male and female half and half, adaptability is divided into 6 groups after raising for 1 week at random: Normal group, ethionine model group, the embodiment of the invention 1 medicine group, the embodiment of the invention 4 medicine groups, the embodiment of the invention 6 medicine groups, hypogastric lipid-lowering pill group.Except Normal group feed normal feedstuff, all the other 5 groups are given high lipid food (normal feedstuff: Adeps Sus domestica: cholesterol: sodium cholate 88.5: 10: 1: 0.5, mass ratio).After feeding for 10 weeks continuously, each group is put to death the part sample at random, gets liver, confirms the modeling success through histopathological examination.
2. treatment administration
From testing the 10th weekend, each organizes rat still as front method is fed, and by following method administration: 1. rats in normal control group press 10mL/kg volume gavage feed water every day, totally 4 weeks.2. the model group rat is pressed the feedwater of 10mL/kg volume gavage, 4 weeks every day totally.3. medicine embodiment of the present invention is 1 group, according to the 0.648g/kg body weight to 1 group of medicine of medicine embodiment of the present invention, totally 4 weeks.4. medicine embodiment of the present invention is 4 groups, according to the 0.648g/kg body weight to 4 groups of medicines of medicine embodiment of the present invention, totally 4 weeks.5. medicine embodiment of the present invention is 6 groups, according to the 0.648g/kg body weight to 6 groups of medicines of medicine embodiment of the present invention, totally 4 weeks.6. positive control medicine group (hypogastric lipid-lowering pill group) gives hypogastric lipid-lowering pill according to the 0.720g/kg body weight, totally 4 weeks.After treating for 4 weeks, behind the rat fasting 12h, get blood from portal vein, get supernatant after centrifugal, automatic clinical chemistry analyzer is measured TC, TG, HDL-C, LDL-C; Take out rapidly liver, make 10%(m/m in the frozen water) liver tissue homogenate, get supernatant behind the high speed centrifugation, automatic clinical chemistry analyzer is measured hepatocyte inner lipid (TC, TG).Other gets hepatic tissue 5mm * 5mm, is soaked in 10% (m/m) formalin to fix, and paraffin embedding, section, HE dyeing is observed blood lipid and is changed under the light microscopic.
3. result of the test
(1) ordinary circumstance is observed high lipid food and is fed rat appetite in early stage greater than Normal group, and body weight increases very fast, and later stage appetite reduces, and activity reduces.It is blunt that each organizes High-fat diet rat 10 all afterreaction compared with normal matched groups, and the hair color jaundice tarnishes, and happiness flocks together, and lazyness is moved and food ration reduces gradually.The embodiment of the invention 1,4, the rear hair color of 6 medicine groups treatment recover normally gradually behind the gastric infusion, and behavioral activity increases.
(2) organize respectively behind the variation drug treatment of experimental rat serum cholesterol, triglyceride, high density lipoprotein and low density lipoprotein, LDL that each group the results are shown in Table 1, table 2 and table 3.
Serum TC respectively organized by table 1 and the TG level compares
Compare ###P＜0.001 with model control group
Table 2 is respectively organized rat blood serum CHO, TG level relatively
With model control group ratio, #P＜0.05, ##P＜0.01, ###P＜0.001
By as seen from Table 1, rat oral gavage gives behind the high lipid food that TC, TG numerical value all significantly raise in the blood, give the embodiment of the invention 1,4, the treatment of 6 medicine groups after, TC, TG numerical value reduce.Statistical procedures shows, compares with model control group, and TC, TG numerical value have extremely significant difference (P＜0.001) in the medicine group blood of the present invention.
By as seen from Table 2, rat oral gavage gives behind the high lipid food that HDL-C numerical value significantly reduces in the blood, give the embodiment of the invention 1,4, the treatment of 6 medicine groups after, HDL-C numerical value raises.Statistical procedures shows, compares with model control group, and medicine group HDL-C numerical value of the present invention has significant differences (P＜0.01).Rat oral gavage gives behind the high lipid food that LDL-C numerical value significantly raises in the blood, give the embodiment of the invention 1,4, the treatment of 6 medicine groups after, LDL-C numerical value reduces.Statistical procedures shows, compares with model control group, and medicine group LDL-C numerical value of the present invention has extremely significant difference (P＜0.001).
(3) respectively organize the variation of experimental rat liver inner cholesterol, triglyceride
Each group the results are shown in Table 3 behind the drug treatment.
Table 3 is respectively organized TC in the rats'liver, TG level relatively
With model control group ratio, ###P＜0.001
By as seen from Table 3, rat oral gavage gives behind the high lipid food that TC, TG numerical value all significantly raise in the liver, gives after the embodiment of the invention 1,4, the treatment of 6 medicine groups after the treatment, and TC, TG numerical value reduce.Statistical procedures shows, compares with model control group, and TC, TG numerical value all have extremely significant difference (P＜0.001) in the medicine group liver of the present invention.
(4) liver morphology and sections observation
Perusal: rats in normal control group liver color is ruddy, and peplos is complete, smooth surface, and clear-cut margin, quality is soft.Model group rat liver color is crineous, liver enlargement, and matter is crisp, and peplos is nervous, and fat drips and is dispersed in distribution, surface uniform distributed granule shape projection.After the embodiment of the invention 1,4, the treatment of 6 medicine groups, rat liver is brown, and liver size and quality are obviously improved than model group, is dispersed in a small amount of white fat that distributes and drips surface uniform distributed granule shape projection.Positive controls (hypogastric lipid-lowering pill group) liver presents brown, and Liver on Judge Hardness improves than model group, drips distribution without white fat, and the graininess projection reduces.
Pathology section examination: rats in normal control group hepatic tissue structure is normal, and sinus hepaticus is high-visible, liver rope marshalling, and the fat-free degeneration of hepatocyte, cellularity is clear, and Cytoplasm is abundant, and nucleus is positioned at cell central authorities.The model group rat liver is moderate or severe steatosis, and with the most obvious around the central vein, swelling of liver cell is rounded, and nucleus is pressed against on one side, is full of the significant quantities of fat cavity in the endochylema, and fat drips and differs in size, even is fused into large fat and drips.The embodiment of the invention 1,4,6 medicine groups obviously reduce than model group steatosis cell, and fat drips minimizing; Hypogastric lipid-lowering pill group hepatocyte form and boundary clear, but the steatosis cell of visible a greater number, fat drips less.
Abnormal morphology and behavioral indicator that experimental result demonstrates the nonalcoholic fatty liver model rat that medicine of the present invention induces high fat diet have a better role, can reduce TG, TC numerical value in the rat model serum regulating liver-QI, increase HDL-C numerical value, reduce LDL-C numerical value, regulate the lipid metabolism of rats with nonalcoholic fatty liver disease liver, histopathology proved invention medicine can alleviate hepatocyte fat and become.In a word, medicine of the present invention can improve liver function, effectively treats non-alcoholic fatty liver disease.
Claims (7)
1. Chinese medicine for the treatment of non-alcoholic fatty liver disease, it is characterized in that its weight part ratio consists of: 9～12 parts on Pericarpium Citri Reticulatae Viride, 9～12 parts of Radix Curcumaes, 12～15 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Rhizoma Dioscoreaes, 12～18 parts in Poria, 12～18 parts of Rhizoma Alismatis, 12～18 parts of Semen Cassiaes, 12～18 parts of Fructus Crataegis, 12～18 parts of Radix Salviae Miltiorrhizaes, 9～12 parts on Flos Carthami;
Preparation method comprises that step is as follows:
(1) Rhizoma Dioscoreae, Poria were ground into respectively the fine powder of 100 mesh sieves;
(2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi are adopted ethanol extraction, filter, filtrate recycling ethanol and when being condensed into relative density and being 50-80 ℃ the clear paste of 1.10-1.25 for subsequent use;
(3) Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae are added water distillation and extraction volatile oil, with the beta-schardinger dextrin-inclusion of volatile oil with 5-12 times of volatile oil quality, the beta-cyclo dextrin included compound that gets volatile oil is for subsequent use, and water liquid in addition device is preserved;
(4) Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water, filter, the water liquid that filtrate and Pericarpium Citri Reticulatae Viride, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae extract behind the volatile oil merges, the concentrated solution of 1.05-1.15 when being concentrated into relative density and being 50-80 ℃;
(5) concentrated solution of step (4) is added ethanol and stirs, staticly settle and filter, filtrate recycling ethanol and when being condensed into relative density and being 50-80 ℃ the clear paste of 1.10-1.25 for subsequent use;
(6) with step (2) Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi with ethanol extraction after concentrated clear paste and the clear paste merging that step (5) obtains, Rhizoma Dioscoreae, Poria fine powder are put in the one-step-granulating method, spray into above-mentioned merging clear paste one-step palletizing and be drying to obtain granule;
(7) with the beta-cyclo dextrin included compound of Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae volatile oil, and step (6) granule be mixed into granulate mixture, add the lubricant of granulate mixture weight 0.5-0.8%, tabletting, film coating.
2. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1 is characterized in that, wherein Pericarpium Citri Reticulatae Viride is stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar; Semen Cassiae is Semen Cassiae (parched); Rhizoma Alismatis is Rhizoma Alismatis (processeded with salt); The Rhizoma Atractylodis Macrocephalae is Rhizoma Atractylodis Macrocephalae (parched with bran); Fructus Crataegi is Fructus Crataegi (parched).
3. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1, it is characterized in that the described ethanol volumetric concentration of step (2) is 75%-95%, the 4-12 that each addition is Radix Salviae Miltiorrhizae, Semen Cassiae, Fructus Crataegi gross mass doubly, extract 2-3 time, extracted 1-2 hour at every turn.
4. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1 is characterized in that, step (3) amount of water is Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Atractylodis Macrocephalae gross mass 3-6 times, extracts volatile oil 4-10 hour.
5. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1, it is characterized in that, the described inclusion of step (3) is ground or is stirred for beta-schardinger dextrin-being added suitable quantity of water, then drip volatile oil, grind again or stir, inclusion complex grinds 40-50 ℃ of drying, gets the beta-cyclo dextrin included compound of volatile oil.
6. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1, it is characterized in that, step (4) is that the Radix Salviae Miltiorrhizae behind the Pericarpium Citri Reticulatae Viride behind Flos Carthami, Rhizoma Alismatis and the extraction volatile oil, Radix Curcumae, Rhizoma Atractylodis Macrocephalae residue and the ethanol extraction, Semen Cassiae, Fructus Crataegi residue are merged, decoct with water 2-3 time, decoct medicine gross mass 5-12 water doubly each the adding, decocted 1-2 hour at every turn.
7. the Chinese medicine for the treatment of non-alcoholic fatty liver disease according to claim 1, it is characterized in that, step (5) is that 95% alcoholic solution stirs for the concentrated solution of step (4) being added volumetric concentration, adds 95% amount of alcohol and be the 1-2 of step (4) concentrated solution quality doubly, staticly settles and filters.
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| CN1965965A (en) * | 2006-11-14 | 2007-05-23 | 陈江 | Beverage for treating fatty liver |
| CN101015668A (en) * | 2007-01-16 | 2007-08-15 | 李卓伦 | Fatty liver treating medicine |
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| CN102225179A (en) * | 2011-05-31 | 2011-10-26 | 刘东升 | Traditional Chinese preparation for treating non-alcoholic fatty liver |
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| CN1965965A (en) * | 2006-11-14 | 2007-05-23 | 陈江 | Beverage for treating fatty liver |
| CN101015668A (en) * | 2007-01-16 | 2007-08-15 | 李卓伦 | Fatty liver treating medicine |
| CN101062367A (en) * | 2007-06-07 | 2007-10-31 | 李春青 | Composite Chinese medicine for treating fatty liver |
| CN102233079A (en) * | 2010-04-26 | 2011-11-09 | 张金荣 | Defatting Chinese medicinal composition and preparation method thereof |
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