CN104383373A - Medicine for treating hyperlipemia and preparation method of same - Google Patents
Medicine for treating hyperlipemia and preparation method of same Download PDFInfo
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- CN104383373A CN104383373A CN201410699973.9A CN201410699973A CN104383373A CN 104383373 A CN104383373 A CN 104383373A CN 201410699973 A CN201410699973 A CN 201410699973A CN 104383373 A CN104383373 A CN 104383373A
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Abstract
The invention discloses a medicine for treating hyperlipemia and a preparation method of the same. The medicine for treating the hyperlipemia is mainly prepared from the following raw materials in a certain weight ratio: pubescent holly root, lotus leaves, hawthorn, artemisia capillaries, kudzuvine root, polygonum multiflorum, parasitic loranthus, semen cassiae, malt, fructus lycii and salviae miltiorrhizae. The medicine for treating the hyperlipemia has the effects of activating blood to dredge vessels, promoting spleen yang and resolving the flesh, relieving restlessness and quenching thirst as well as tonifying the kidney and nourishing blood, effect is taken quickly when the medicine disclosed by the invention is used for treating the hyperlipemia, curative effect is good, and no side effect is produced.
Description
Technical field
The present invention relates to a kind of medicine being used for the treatment of hyperlipidemia and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Hyperlipidemia refers to that blood lipid level is too high, directly can cause the disease of some serious harm healths, as atherosclerosis, coronary heart disease, pancreatitis etc.Hyperlipemia can be divided into constitutional and Secondary cases two class.Constitutional is relevant with heredity with congenital, due to single-gene defect or polygenes defect, make the receptor of the transhipment of participation lipoprotein and metabolism, enzyme or apolipoprotein caused by abnormal, or cause due to environmental factors (diet, nutrition, medicine) with by unknown mechanism.Secondary cases is multiple is born in metabolic disorder disease (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal cortex function are hyperfunction), or with other factor age, sex, season, drink, smoking, diet, physical exertion, psychentonia, emotional activity etc. be relevant.At present, Western medicine effectively cannot treat hyperlipidemia, and Long-term taking medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating hyperlipidemia.
Summary of the invention
The present inventor, through research repeatedly and clinical test repeatedly and checking, finally have found the medicine of effectively treatment hyperlipidemia, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating hyperlipidemia.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Ilicis Pubescentis, Folium Nelumbinis, Fructus Crataegi, Herba Artemisiae Scopariae, Radix Puerariae, Radix Polygoni Multiflori, Herba Taxilli, Semen Cassiae, Fructus Hordei Germinatus, Fructus Lycii, Radix Salviae Miltiorrhizae, the Rhizoma Pinelliae, Rhizoma Alismatis, Rhizoma Atractylodis, Poria, Radix Glycyrrhizae, Cortex Acanthopancis, pseudo-ginseng medicament to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating hyperlipidemia.Radix Ilicis Pubescentis is wherein selected to be that property is put down, nontoxic because its property mildly bitter flavor is sweet, have heat-clearing and toxic substances removing, the function of blood circulation and channel invigorating, controls anemopyretic cold, dyspnea and cough due to lung-heat, laryngeal edema, tonsillitis, dysentery, coronary heart disease, the hemiplegia caused by cerebrovas-cularaccident, thromboangiitis obliterans, erysipelas, scalds, central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation.Select Folium Nelumbinis to be because its nature and flavor are pained, flat, enter the heart, liver, spleen channel, have clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the function of hemostasis, control diarrhea due to summer heat and dampness, dizzy, aqueous vapor edema, thunder-headache, spit blood, epistaxis, metrorrhagia, has blood in stool, puerperal blood faints.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Herba Artemisiae Scopariae is selected to be because its nature and flavor toil, cool, enter liver, spleen, urinary bladder channel, have the function of clearing away heat-damp and promoting diuresis, control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Select Radix Puerariae to be that flat, enter spleen, stomach warp, have yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is only drunk, cure the wound cold, cure the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery because its nature and flavor are sweet pungent, skin eruption is not saturating, hypertension, and angina pectoris is deaf.Radix Polygoni Multiflori is selected to be that tepor, enters liver, kidney channel, have tonifying liver, kidney tonifying, nourish blood, the function of dispeling the wind because its property bitter but sweet flavor is puckery, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Semen Cassiae is selected to be because its property bitter but sweet flavor, cool, enter liver, kidney channel, have liver heat removing, improving eyesight, diuretic, the function of relieving constipation, control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, liver cirrhosis abdomen, habitual constipation.Fructus Hordei Germinatus is selected to be that tepor, enters spleen, stomach warp, have and help digestion because its nature and flavor are sweet, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, swollen distention and fullness in the abdomen, inappetence, and vomiting is had loose bowels, and mammary swelling does not disappear.Select Fructus Lycii to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, lose clear.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of clear painful abdominal mass eliminating stagnation, control the vomiting of damp-phlegm cold drink, regurgitation, cough with asthma abundant expectoration, my diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria, edema distension, phlegm retention cough with dyspnea, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Cortex Acanthopancis to be that return liver, kidney channel, have wind-damp dispelling, strengthening bone and muscle, the function of blood circulation and promoting silt, controls anemofrigid-damp arthralgia because its property and flavor of peppery and warm, the sliding contraction of muscle is anxious, edema beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Ilicis Pubescentis 55-65 gram of Folium Nelumbinis 25-30 Keshan short, bristly hair or beard 25-30 gram
Herba Artemisiae Scopariae 25-30 gram of Radix Puerariae 10-15 gram of Radix Polygoni Multiflori 10-15 gram
Herba Taxilli 10-15 gram of Semen Cassiae 20-25 gram of Fructus Hordei Germinatus 20-25 gram
Fructus Lycii 20-25 gram of Radix Salviae Miltiorrhizae 8-10 gram of Rhizoma Pinelliae 8-10 gram
Rhizoma Alismatis 8-10 gram of Rhizoma Atractylodis 8-10 gram of Poria 8-10 gram
Radix Glycyrrhizae 8-10 gram of Cortex Acanthopancis 8-10 gram of Radix Notoginseng 2-3 gram
Preferable amount is
Radix Ilicis Pubescentis 60 grams of Folium Nelumbinis 27 Keshan short, bristly hair or beards 27 grams
Herba Artemisiae Scopariae 27 grams of Radix Puerariaes 13 grams of Radix Polygoni Multiflori 13 grams
23 grams, Herba Taxilli 13 grams of Semen Cassiaes 23 grams of Fructus Hordei Germinatus
Fructus Lycii 23 grams of Radix Salviae Miltiorrhizaes 9 grams of Rhizoma Pinelliaes 9 grams
9 grams, Rhizoma Alismatis 9 grams of Rhizoma Atractylodis 9 grams of Poria
Radix Glycyrrhizae 9 grams of Cortex Acanthopanciss 9 grams of Radix Notoginseng 3 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Ilicis Pubescentis: summer, Qiu Cai, section is dried;
2, Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;
3, Fructus Crataegi: pick clean impurity, sieve enucleation;
4, Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;
5, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
6, Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;
7, Herba Taxilli: wash, runs through, and cutting is dried;
8, Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;
9, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;
10, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
11, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
12, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
13, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
14, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;
15, Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
16, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, run through, section, dries;
17, Cortex Acanthopancis: pick clean impurity, wash, slightly after profit, section, dry;
18, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry.
Two, prepare
1, by the Radix Ilicis Pubescentis of described weight, Folium Nelumbinis, Fructus Crataegi, Herba Artemisiae Scopariae, Radix Puerariae, Radix Polygoni Multiflori, Herba Taxilli, Semen Cassiae, Fructus Hordei Germinatus, Fructus Lycii, Radix Salviae Miltiorrhizae, the Rhizoma Pinelliae, Rhizoma Alismatis, Rhizoma Atractylodis, Poria, Radix Glycyrrhizae, Cortex Acanthopancis, pseudo-ginseng medicament, add water 6 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 5 times amount, first boils with high heat, then use slow fire boiling 20 minutes, second time decoction liquor poured in container.
3, twice decoction liquor is carried out mixing and stirring and namely obtain medicinal liquid, divided by medicinal liquid 3 doses to take.
The present invention selects Radix Ilicis Pubescentis to be monarch drug, and Radix Salviae Miltiorrhizae, Poria are ministerial drug, and Rhizoma Atractylodis are adjuvant drug, and said medicine and all medicines in side, for making medicine, combine, make the medicine for the treatment of hyperlipidemia by Radix Glycyrrhizae.
Medicine of the present invention has blood circulation and channel invigorating, yang invigorating expelling pathogenic factors from muscles, and relieving restlessness is quenched the thirst, effect that kidney tonifying nourishes blood, and treatment hyperlipidemia instant effect, short treating period, does not recur.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy hyperlipidemia of the present invention:
1, physical data
Accept hyperlipemic patients totally 37 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation: the clinical manifestation of hyperlipemia is the xanthoma of lipid caused by intradermal deposition and the arteriosclerosis of lipid caused by blood vessel endothelium deposition mainly.Although hyperlipemia can cause xanthoma, its incidence rate is also not bery high; And atherosclerotic generation and development are a kind of slowly progressive processes.Therefore under normal conditions, most of patients non-evident sympton and abnormal sign.Many people raise owing to just finding that there is blood plasma lipoprotein level when other reasons carries out blood biochemical inspection.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: hyperlipidemia is effectively controlled, triglyceride, apolipoprotein recover normal, observe half a year without bounce-back person;
Take a turn for the better: hyperlipidemia obviously improves, and arteriosclerosis symptom alleviates, and body constitution progressively takes a turn for the better;
Invalid: hyperlipidemia, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy hyperlipemic patients 37 example of the present invention, effective 30 examples of result, obvious effective rate is 81.08%, and take a turn for the better 5 examples, and improvement rate is 5.41%, and invalid 2 examples, total effective rate is 94.59%.
Claims (3)
1. treat a medicine for hyperlipidemia, its feature is asked and is: it is made up of the crude drug in following weight range:
Radix Ilicis Pubescentis 55-65 gram of Folium Nelumbinis 25-30 Keshan short, bristly hair or beard 25-30 gram
Herba Artemisiae Scopariae 25-30 gram of Radix Puerariae 10-15 gram of Radix Polygoni Multiflori 10-15 gram
Herba Taxilli 10-15 gram of Semen Cassiae 20-25 gram of Fructus Hordei Germinatus 20-25 gram
Fructus Lycii 20-25 gram of Radix Salviae Miltiorrhizae 8-10 gram of Rhizoma Pinelliae 8-10 gram
Rhizoma Alismatis 8-10 gram of Rhizoma Atractylodis 8-10 gram of Poria 8-10 gram
Radix Glycyrrhizae 8-10 gram of Cortex Acanthopancis 8-10 gram of Radix Notoginseng 2-3 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Ilicis Pubescentis 60 grams of Folium Nelumbinis 27 Keshan short, bristly hair or beards 27 grams
Herba Artemisiae Scopariae 27 grams of Radix Puerariaes 13 grams of Radix Polygoni Multiflori 13 grams
23 grams, Herba Taxilli 13 grams of Semen Cassiaes 23 grams of Fructus Hordei Germinatus
Fructus Lycii 23 grams of Radix Salviae Miltiorrhizaes 9 grams of Rhizoma Pinelliaes 9 grams
9 grams, Rhizoma Alismatis 9 grams of Rhizoma Atractylodis 9 grams of Poria
Radix Glycyrrhizae 9 grams of Cortex Acanthopanciss 9 grams of Radix Notoginseng 3 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Ilicis Pubescentis: summer, Qiu Cai, section is dried;
(2) Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;
(3) Fructus Crataegi: pick clean impurity, sieve enucleation;
(4) Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;
(5) Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
(6) Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;
(7) Herba Taxilli: wash, runs through, and cutting is dried;
(8) Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;
(9) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;
(10) Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
(11) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
(12) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
(13) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
(14) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;
(15) Poria: be soaked in water, cleans, pulls out, and after vexed, section, dries;
(16) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, run through, section, dries;
(17) Cortex Acanthopancis: pick clean impurity, wash, slightly after profit, section, dry;
(18) Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
(2) prepare
(1) by the Radix Ilicis Pubescentis of described weight, Folium Nelumbinis, Fructus Crataegi, Herba Artemisiae Scopariae, Radix Puerariae, Radix Polygoni Multiflori, Herba Taxilli, Semen Cassiae, Fructus Hordei Germinatus, Fructus Lycii, Radix Salviae Miltiorrhizae, the Rhizoma Pinelliae, Rhizoma Alismatis, Rhizoma Atractylodis, Poria, Radix Glycyrrhizae, Cortex Acanthopancis, pseudo-ginseng medicament, add water 6 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues of filtration 5 times amount, first boils with high heat, then use slow fire boiling 20 minutes, pour in container by second time decoction liquor;
(3) twice decoction liquor is carried out mixing and stirring and namely obtain medicinal liquid.
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| CN105412825A (en) * | 2015-12-14 | 2016-03-23 | 张朝兰 | Drug for treating hyperlipidaemia and preparation method thereof |
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| CN101530558A (en) * | 2008-03-13 | 2009-09-16 | 北京天科仁祥医药科技有限公司 | Traditional Chinese medicine for lowering blood lipid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101530558A (en) * | 2008-03-13 | 2009-09-16 | 北京天科仁祥医药科技有限公司 | Traditional Chinese medicine for lowering blood lipid |
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| CN105412825A (en) * | 2015-12-14 | 2016-03-23 | 张朝兰 | Drug for treating hyperlipidaemia and preparation method thereof |
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Application publication date: 20150304 |
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