CN103432391A - Medicament for treating hyperlipemia and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating hyperlipemia and a preparation method thereof. The medicament is mainly prepared from dried orange peel, hawthorn, rhizoma alismatis, tuckahoe, rhizoma polygonati, red sage root, polygonum multiflorum and the like according to certain weight ratios. The medicament has functions of tonifying middle-jiao and qi, promoting blood circulation to remove blood stasis and reducing blood fat, and does not have toxic or side effects when used for treating hyperlipemia.

Description

A kind of medicine for the treatment of hyperlipidemia and preparation method thereof

Technical field

The present invention relates to a kind of medicine that is used for the treatment of hyperlipidemia and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Blood fat is the general name of contained lipid in human plasma, comprising cholesterol, triglyceride, cholesterol ester, beta lipoprotein, phospholipid, not esterified fat acid etc.When serum cholesterol surpasses 230 milligrams/100 milliliters of normal values, triglyceride surpasses 140 milligrams/100 milliliters, beta lipoprotein surpass 390 milligrams/more than 100 milliliters the time, be referred to as hyperlipidemia.At present, Western medicine can't effectively be treated hyperlipidemia, and Long-term taking medicine has more side effect, and therefore, there is very large demand in people to the Chinese medicine of effective treatment hyperlipidemia.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment hyperlipidemia, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat hyperlipidemia.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Pericarpium Citri Reticulatae, Fructus Crataegi, Rhizoma Alismatis, Poria, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Pinelliae medicine to be combined, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can the fast treating hyperlipidemia.Wherein select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature, return lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm, control fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Fructus Crataegi to be because its nature and flavor acid is sweet, tepor, enter spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, control meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function expelled the heat-evil, control dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, invigorating the spleen and replenishing QI is arranged, the profit cardiopulmonary, the function of bone and muscle strengthening, control deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones weakness, rheumatalgia, wind favus disease.Selecting Radix Salviae Miltiorrhizae is that tepor, enter the heart, Liver Channel, and blood circulation and promoting silt is arranged because of its nature and flavor hardship, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, control angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gather, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Polygoni Multiflori to be because its property bitter but sweet flavor is puckery, tepor, enter liver, kidney channel, and tonifying liver is arranged, and kidney tonifying, nourish blood, the function of dispeling the wind, control hepatic and renal YIN deficiency, sending out must be early white, the blood deficiency dizziness, and waist knee joint weakness, muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Fructus Lycii to be because its nature and flavor are sweet, flat, nourishing kidney is arranged, lung moistening, tonifying liver, the function of improving eyesight, control hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quench one's thirst, and loses clear.Selecting Cortex Magnoliae Officinalis is that temperature, enter spleen, stomach, large intestine channel, and warming middle-JIAO is arranged because of its nature and flavor toil, the therapeutic method to keep the adverse QI flowing downwards, and dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, the cold-damp dysentery.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription are arranged and middle emergency; Process use, control the taste lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Give birth to use, control laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separate poison of drug and alimentary toxicosis.Selecting the Rhizoma Pinelliae is because of its nature and flavor suffering, and temperature is poisonous, enters spleen, stomach warp, and drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, and the function of dissolving lump and resolving mass, control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Pericarpium Citri Reticulatae 8-15 Keshan short, bristly hair or beard 10-20 gram Rhizoma Alismatis 10-20 gram

Poria 8-15 gram Rhizoma Polygonati 10-20 gram Radix Salviae Miltiorrhizae 10-20 gram

Radix Polygoni Multiflori 10-20 gram Fructus Lycii 8-15 gram cortex Magnoliae Officinalis 6-10 gram

Radix Glycyrrhizae 8-15 gram Rhizoma Pinelliae 8-15 gram

Preferable amount is

Pericarpium Citri Reticulatae 10 Keshan short, bristly hair or beard 15 gram Rhizoma Alismatis 15 grams

Poria 10 gram Rhizoma Polygonati 15 gram Radix Salviae Miltiorrhizae 15 grams

Radix Polygoni Multiflori 15 gram Fructus Lycii 10 gram Cortex Magnoliae Officinalis 8 grams

The Radix Glycyrrhizae 10 gram Rhizoma Pinelliae 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dry or cold drying, sieve dedust bits;

2, Fructus Crataegi: choose clean impurity, the sieve enucleation;

3, Rhizoma Alismatis: choose decontamination, big or small stepping, be soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, cut dry;

4, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

5, Rhizoma Polygonati: clean earth, slightly profit, cut into slices, and dries;

6, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

7, Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;

8, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

9, Cortex Magnoliae Officinalis: be soaked in water and pull out, after running through, scrape off rough bark, clean, shredding, dry;

10, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, dry;

11, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits.

Two, preparation

By the Pericarpium Citri Reticulatae of described weight, Fructus Crataegi, Rhizoma Alismatis, Poria, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Pinelliae medicine, add 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 25 minutes, use again slow fire boiling 25 minutes, filter and get final product, will decoct medicinal liquid and pour in container, be divided into 3 doses and take.

Medicine of the present invention has invigorating the spleen and replenishing QI, blood circulation and promoting silt, and the function of blood fat reducing, be used for the treatment of hyperlipidemia, short treating period, instant effect, has no side effect.

The specific embodiment

Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, every day 2 times, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy hyperlipidemia of the present invention

1, physical data

Accept hyperlipemia totally 180 examples for medical treatment, male's 130 examples wherein, women's 50 examples.

2, diagnostic criteria

Clinical manifestation: hyperlipemia is called as reticent killer, so-called " silence ", refer to subjective symptoms not obvious when the people suffers from hyperlipemia, often in hyperlipemia, cause that hypertension, angina pectoris, myocardial infarction even just check out to suffer from hyperlipemia during cerebrovascular, in fact blood fat disorder is being encroached on the body vitals already dumbly.The pathogenic of it is a process very slowly; be usually from person between twenty and fifty even the child just started period; in default of uncomfortable sensation; often can not find in time; if the Lipid increase time is longer; the atherosclerosis that lipid causes in the blood vessel endothelium deposition, can cause a series of body symptom of human body and pathological change.The body symptom comprises: dizziness, headache, uncomfortable in chest, cardiopalmus, dizzy, forgetful, hand and foot numbness, ice-cold, abdominal distention, fatiguability and lethargy etc.; Pathological change comprises: coronary heart disease, angiemphraxis, arterial sclerosis, hypertension, heart disease, apoplexy, diabetes, cholelithiasis and fatty liver etc.

3, Therapeutic Method

Select described medicament, take to the patient, each serving with 1 dose, every day, early, middle and late respectively the clothes 1 time, 30 days be a course for the treatment of, takes continuously 3 courses for the treatment of.

4, efficacy assessment standard

Produce effects: hyperlipidemia disappears, and observes half a year without bounce-back person;

Take a turn for the better: hyperlipidemia is obviously improved, and body constitution progressively strengthens;

Invalid: hyperlipidemia, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy hyperlipemia 180 examples of the present invention, produce effects 172 examples as a result, obvious effective rate is 95.56%, 4 examples that take a turn for the better, improvement rate is 2.22%, invalid 4 examples, total effective rate is 97.78%.

Claims (3)

1. a medicine for the treatment of hyperlipidemia, it is characterized in that: it is to be made by the crude drug in following weight range:

Pericarpium Citri Reticulatae 8-15 Keshan short, bristly hair or beard 10-20 gram Rhizoma Alismatis 10-20 gram

Poria 8-15 gram Rhizoma Polygonati 10-20 gram Radix Salviae Miltiorrhizae 10-20 gram

Radix Polygoni Multiflori 10-20 gram Fructus Lycii 8-15 gram Cortex Magnoliae Officinalis 6-10 gram

Radix Glycyrrhizae 8-15 gram Rhizoma Pinelliae 8-15 gram.

2. external used medicine according to claim 1, wherein the consumption of each crude drug is:

Pericarpium Citri Reticulatae 10 Keshan short, bristly hair or beard 15 gram Rhizoma Alismatis 15 grams

Poria 10 gram Rhizoma Polygonati 15 gram Radix Salviae Miltiorrhizae 15 grams

Radix Polygoni Multiflori 15 gram Fructus Lycii 10 gram Cortex Magnoliae Officinalis 8 grams

The Radix Glycyrrhizae 10 gram Rhizoma Pinelliae 10 grams.

3. according to the preparation method of claim 1 or 2 described medicine, it comprises the following steps:

(1) get the raw materials ready

(1) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dry or cold drying, sieve dedust bits;

(2) Fructus Crataegi: choose clean impurity, the sieve enucleation;

(3) Rhizoma Alismatis: choose decontamination, big or small stepping, be soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, cut dry;

(4) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(5) Rhizoma Polygonati: clean earth, slightly profit, cut into slices, and dries;

(6) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(7) Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;

(8) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(9) Cortex Magnoliae Officinalis: be soaked in water and pull out, after running through, scrape off rough bark, clean, shredding, dry;

(10) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, dry;

(11) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(2) preparation

By the Pericarpium Citri Reticulatae of described weight, Fructus Crataegi, Rhizoma Alismatis, Poria, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Pinelliae medicine, add 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 25 minutes, use again slow fire boiling 25 minutes, filter and get final product, will decoct medicinal liquid and pour in container, be divided into 3 doses and take.