CN107412495A - A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat and preparation method thereof - Google Patents
A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The present invention relates to prepared slices of Chinese crude drugs formula of a kind of lowering blood pressure and blood fat and preparation method thereof, the prepared slices of Chinese crude drugs formula is made up of by weight ratio following raw material:28-32 parts of hawthorn;14-16 parts of Poria cocos;10-12 parts of dried orange peel;10-12 parts of radix bupleuri;10-12 parts of grass-leaved sweetflag;10-12 parts of rhizoma alismatis;8-10 parts of the tuber of pinellia;8-10 parts of the dried immature fruit of citron orange;5-7 parts of radix glycyrrhizae;The present invention has abundant raw material, drug safety, quick, the advantages of having no side effect.
Description
Technical field
The invention belongs to Chinese medicine preparation technical field, and in particular to the prepared slices of Chinese crude drugs formula and its system of a kind of lowering blood pressure and blood fat
Preparation Method.
Background technology
With the increasingly raising of people's living standard, the incidence of disease of hyperlipidemia substantially rises, and the disease is to cause artery
One of hardening, coronary heart disease and the pathogenetic Major Risk Factors of the cerebrovascular, hypertension are most common chronic diseases, and heart and brain blood
The most important hazards of pipe disease, hypertension, hyperlipemia disease have had a strong impact on the quality of life of many people, are even endangered when serious
To the life security of patient, control blood pressure blood fat is extremely important for hypertension blood fat patient, and is taken exercise and drunk by itself
Food control is often ineffective, and the prepared slices of Chinese crude drugs are Chinese medicine common in recent years with taking mode, its have it is convenient and swift, be easy to carry
The advantages that, therefore, a kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat is developed, hypertension blood fat patient is using such a prepared slices of Chinese crude drugs
Afterwards, hypotensive, control blood fat, Jianpi Huayu, qi-regulating clearing damp, the effect of prevention of cardiovascular disease are played.
The content of the invention
The invention aims to overcome the deficiencies in the prior art, and provide a kind of hypotensive, control blood fat, invigorating the spleen
The stasis of blood, qi-regulating clearing damp, the prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat and preparation method thereof of prevention of cardiovascular.
The object of the present invention is achieved like this:A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat, the prepared slices of Chinese crude drugs formula
It is made up of by weight ratio following raw material:28-32 parts of hawthorn;14-16 parts of Poria cocos;10-12 parts of dried orange peel;Radix bupleuri 10-12
Part;10-12 parts of grass-leaved sweetflag;10-12 parts of rhizoma alismatis;8-10 parts of the tuber of pinellia;8-10 parts of the dried immature fruit of citron orange;5-7 parts of radix glycyrrhizae.
Described hawthorn uses haw flakes, it be by fresh hawthorn is cleaned, section, drying, obtained sheet after sterilization
Hawthorn.
Described Poria cocos uses Poria cocos block, it be by fresh excavation Poria cocos is cleaned, stripping and slicing, dry, sterilize after obtain
Block Poria cocos.
Described dried orange peel uses dried orange peel bar.
Described radix bupleuri, grass-leaved sweetflag, rhizoma alismatis, the tuber of pinellia, the dried immature fruit of citron orange, radix glycyrrhizae are respectively adopted sheet and dry radix bupleuri rhizome, sheet stone
Calamus dry rhizome, sheet rhizoma alismatis dry tuber, sheet tuber of pinellia dry tuber, the sheet dried immature fruit of citron orange dry young fruit, sheet radix glycyrrhizae is dried
Rhizome.
It is made up of each component according to following weight proportion:30 grams of hawthorn;15 grams of Poria cocos;12 grams of dried orange peel;12 grams of radix bupleuri;
12 grams of grass-leaved sweetflag;12 grams of rhizoma alismatis;10 grams of the tuber of pinellia;10 grams of the dried immature fruit of citron orange;6 grams of radix glycyrrhizae.
The preparation method of the prepared slices of Chinese crude drugs formula comprises the following steps:
Step 1:Selection;Choose qualified various medicinal raw materials;
Step 2:Produce raw material;The various medicinal raw materials chosen in step 1 are subjected to removal of impurities processing respectively, and choose hawthorn respectively
Fruit, Poria cocos rhizome, dried orange peel, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber, tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit, radix glycyrrhizae rhizome are made
For medicinal part;
Step 3:Cleaning;Each medicinal part chosen in step 2 is subjected to cleaning treatment;
Step 4:Shaping;By the Fructus Crataegi after cleaned processing in step 3, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber,
Tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit and radix glycyrrhizae rhizome make slicing treatment respectively;Poria cocos rhizome after cleaned processing in step 3 is cut
Block processing;Dried orange peel after cleaned processing in step 3 is made into slitting processing;
Step 5:Dry;By obtained sheet hawthorn, block Poria cocos, strip dried orange peel, sheet radix bupleuri rhizome, sheet stone in step 4
Processing is dried in calamus rhizome, sheet rhizoma alismatis stem tuber, sheet tuber of pinellia stem tuber, sheet dried immature fruit of citron orange young fruit and sheet radix glycyrrhizae rhizome;
Step 6:Mixing;By obtained dry sheet hawthorn, dry block Poria cocos, dry strip dried orange peel, dry sheet in step 5
Radix bupleuri rhizome, sheet root of Rhizoma Acori Graminei stem is dried, sheet rhizoma alismatis stem tuber is dried, dries sheet tuber of pinellia stem tuber, dries sheet dried immature fruit of citron orange children
Fruit and dry sheet licorice stem, are uniformly mixed according to the weight proportion described in claim 1;
Step 7:Sterilization;Obtained tablet mixture in step 6 is subjected to sterilization processing, and the weight described according to claim 6
Amount proportioning carries out packing processes.
Set theory of traditional Chinese medical science illustrates beneficial effects of the present invention below:
Radix bupleuri in present invention configuration raw material has the effect of harmonizing Sharyang, easypro liver and stomach, yang invigorating, and Poria cocos and rhizoma alismatis can rise
To clearing damp and promoting diuresis, invigorating the spleen, calming heart, expel the heat-evil this effect of, dried orange peel return lung, the spleen channel, can regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, the dried immature fruit of citron orange has
Relieving stagnant Qi, the effect for dissipating ruffian, rushing down phlegm, disperse accumulations, the tuber of pinellia have eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass, and grass-leaved sweetflag has
Dissipating phlegm for resuscitation, the effect of dampness elimination promoting the circulation of qi, can wind-dispelling profit numbness, swelling and pain relieving, hawthorn has antihypertensive, high fat of blood, high fat of blood
Effect, significant effect, and also have very effect for atherosclerosis, there is radix glycyrrhizae invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moistening lung to stop
Cough, the effect of purging intense heat and detonicating, and the coordinating the drug actions of a prescription on the basis of this effect, under making various spice effects neat, this prepared slices of Chinese crude drugs compatibility
Rationally, effect is notable, and the present invention has abundant raw material, drug safety, quick, the advantages of having no side effect.
Specific embodiment
Embodiment 1
A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat, the prepared slices of Chinese crude drugs formula are made up of by weight ratio following raw material:Mountain
29 parts of short, bristly hair or beard;14 parts of Poria cocos;10 parts of dried orange peel;10 parts of radix bupleuri;10 parts of grass-leaved sweetflag;10 parts of rhizoma alismatis;8 parts of the tuber of pinellia;8 parts of the dried immature fruit of citron orange;Radix glycyrrhizae 5
Part;Described hawthorn uses haw flakes, it be by fresh hawthorn is cleaned, section, drying, obtained sheet hawthorn after sterilization;
Described Poria cocos uses Poria cocos block, it be by fresh excavation Poria cocos is cleaned, stripping and slicing, dry, sterilize after obtained block Fu
Siberian cocklebur;Described dried orange peel uses dried orange peel bar;Sheet drying is respectively adopted in described radix bupleuri, grass-leaved sweetflag, rhizoma alismatis, the tuber of pinellia, the dried immature fruit of citron orange, radix glycyrrhizae
Radix bupleuri rhizome, sheet grass-leaved sweetflag dry rhizome, sheet rhizoma alismatis dry tuber, sheet tuber of pinellia dry tuber, the sheet dried immature fruit of citron orange dry children
Fruit, sheet radix glycyrrhizae dry rhizome.
Radix bupleuri in present invention configuration raw material has the effect of harmonizing Sharyang, easypro liver and stomach, yang invigorating, Poria cocos and rhizoma alismatis
Clearing damp and promoting diuresis can be played, invigorating the spleen, calming heart, expelled the heat-evil this effect of, dried orange peel return lung, the spleen channel, can regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, the dried immature fruit of citron orange
There is relieving stagnant Qi, dissipate ruffian, rush down phlegm, disperse accumulations, the tuber of pinellia has eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass, grass-leaved sweetflag
Effect with dissipating phlegm for resuscitation, dampness elimination promoting the circulation of qi, can wind-dispelling profit numbness, swelling and pain relieving, hawthorn has antihypertensive, high fat of blood, high blood
The effect of fat, significant effect, and also have very effect for atherosclerosis, radix glycyrrhizae has invigorating middle warmer and replenishing QI, relieving spasm to stop pain, profit
Lung cough-relieving, the effect of purging intense heat and detonicating, and the coordinating the drug actions of a prescription on the basis of this effect, under making various spice effects neat, this prepared slices of Chinese crude drugs
Compatibility is reasonable, and effect is notable, and the present invention has abundant raw material, drug safety, quick, the advantages of having no side effect.
Embodiment 2
A kind of prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat, the prepared slices of Chinese crude drugs formula are made up of by weight ratio following raw material:Mountain
32 parts of short, bristly hair or beard;16 parts of Poria cocos;12 parts of dried orange peel;12 parts of radix bupleuri;12 parts of grass-leaved sweetflag;12 parts of rhizoma alismatis;9 parts of the tuber of pinellia;9 parts of the dried immature fruit of citron orange;Radix glycyrrhizae 7
Part;The preparation method of the prepared slices of Chinese crude drugs formula comprises the following steps:Step 1:Selection;Choose qualified various medicinal raw materials;Step
Rapid 2:Produce raw material;The various medicinal raw materials chosen in step 1 are subjected to removal of impurities processing respectively, and choose respectively Fructus Crataegi,
Poria cocos rhizome, dried orange peel, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber, tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit, radix glycyrrhizae rhizome are as medicinal
Position;Step 3:Cleaning;Each medicinal part chosen in step 2 is subjected to cleaning treatment;Step 4:Shaping;It will be passed through in step 3
Cleaned Fructus Crataegi, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber, tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit and radix glycyrrhizae rhizome
Make slicing treatment respectively;Poria cocos rhizome after cleaned processing in step 3 is made into stripping and slicing processing;By cleaned processing in step 3
Dried orange peel afterwards makees slitting processing;Step 5:Dry;By obtained sheet hawthorn, block Poria cocos, strip dried orange peel, sheet in step 4
Radix bupleuri rhizome, sheet grass-leaved sweetflag rhizome, sheet rhizoma alismatis stem tuber, sheet tuber of pinellia stem tuber, sheet dried immature fruit of citron orange young fruit and sheet radix glycyrrhizae rhizome
Processing is dried;Step 6:Mixing;Obtained dry sheet hawthorn, dry block Poria cocos, dry strip in step 5 is old
Skin, sheet radix bupleuri rhizome is dried, sheet root of Rhizoma Acori Graminei stem is dried, dries sheet rhizoma alismatis stem tuber, dries sheet tuber of pinellia stem tuber, drying
Sheet dried immature fruit of citron orange young fruit and dry sheet licorice stem, are uniformly mixed according to the weight proportion described in claim 1;Step 7:
Sterilization;Obtained tablet mixture in step 6 is subjected to sterilization processing, and carried out according to the weight proportion described in claim 6
Packing processes.
Radix bupleuri in present invention configuration raw material has the effect of harmonizing Sharyang, easypro liver and stomach, yang invigorating, Poria cocos and rhizoma alismatis
Clearing damp and promoting diuresis can be played, invigorating the spleen, calming heart, expelled the heat-evil this effect of, dried orange peel return lung, the spleen channel, can regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, the dried immature fruit of citron orange
There is relieving stagnant Qi, dissipate ruffian, rush down phlegm, disperse accumulations, the tuber of pinellia has eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass, grass-leaved sweetflag
Effect with dissipating phlegm for resuscitation, dampness elimination promoting the circulation of qi, can wind-dispelling profit numbness, swelling and pain relieving, hawthorn has antihypertensive, high fat of blood, high blood
The effect of fat, significant effect, and also have very effect for atherosclerosis, radix glycyrrhizae has invigorating middle warmer and replenishing QI, relieving spasm to stop pain, profit
Lung cough-relieving, the effect of purging intense heat and detonicating, and the coordinating the drug actions of a prescription on the basis of this effect, under making various spice effects neat, this prepared slices of Chinese crude drugs
Compatibility is reasonable, and effect is notable, and the present invention has abundant raw material, drug safety, quick, the advantages of having no side effect.
Claims (7)
- A kind of 1. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat, it is characterised in that:The prepared slices of Chinese crude drugs formula is by weight by following raw material Amount proportioning composition:28-32 parts of hawthorn;14-16 parts of Poria cocos;10-12 parts of dried orange peel;10-12 parts of radix bupleuri;Grass-leaved sweetflag 10-12 Part;10-12 parts of rhizoma alismatis;8-10 parts of the tuber of pinellia;8-10 parts of the dried immature fruit of citron orange;5-7 parts of radix glycyrrhizae.
- A kind of 2. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat as claimed in claim 1, it is characterised in that:Described hawthorn uses Haw flakes, it be by fresh hawthorn is cleaned, section, drying, obtained sheet hawthorn after sterilization.
- A kind of 3. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat as claimed in claim 1, it is characterised in that:Described Poria cocos uses Poria cocos block, it be by fresh excavation Poria cocos is cleaned, stripping and slicing, dry, sterilize after obtained block Poria cocos.
- A kind of 4. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat as claimed in claim 1, it is characterised in that:Described dried orange peel uses Dried orange peel bar.
- A kind of 5. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat as claimed in claim 1, it is characterised in that:Described radix bupleuri, stone Calamus, rhizoma alismatis, the tuber of pinellia, the dried immature fruit of citron orange, radix glycyrrhizae are respectively adopted sheet and dry radix bupleuri rhizome, sheet grass-leaved sweetflag dry rhizome, sheet rhizoma alismatis Dry tuber, sheet tuber of pinellia dry tuber, the sheet dried immature fruit of citron orange dry young fruit, sheet radix glycyrrhizae dry rhizome.
- A kind of 6. prepared slices of Chinese crude drugs formula of lowering blood pressure and blood fat as claimed in claim 1, it is characterised in that:It is by each component by It is made according to following weight proportion:30 grams of hawthorn;15 grams of Poria cocos;12 grams of dried orange peel;12 grams of radix bupleuri;12 grams of grass-leaved sweetflag;12 grams of rhizoma alismatis;Half 10 grams of summer;10 grams of the dried immature fruit of citron orange;6 grams of radix glycyrrhizae.
- A kind of 7. preparation method of the prepared slices of Chinese crude drugs of lowering blood pressure and blood fat, it is characterised in that:Described preparation method includes following step Suddenly:Step 1:Selection;Choose qualified various medicinal raw materials;Step 2:Produce raw material;The various medicinal raw materials chosen in step 1 are subjected to removal of impurities processing respectively, and choose hawthorn respectively Fruit, Poria cocos rhizome, dried orange peel, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber, tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit, radix glycyrrhizae rhizome are made For medicinal part;Step 3:Cleaning;Each medicinal part chosen in step 2 is subjected to cleaning treatment;Step 4:Shaping;By the Fructus Crataegi after cleaned processing in step 3, radix bupleuri rhizome, grass-leaved sweetflag rhizome, rhizoma alismatis stem tuber, Tuber of pinellia stem tuber, dried immature fruit of citron orange young fruit and radix glycyrrhizae rhizome make slicing treatment respectively;Poria cocos rhizome after cleaned processing in step 3 is cut Block processing;Dried orange peel after cleaned processing in step 3 is made into slitting processing;Step 5:Dry;By obtained sheet hawthorn, block Poria cocos, strip dried orange peel, sheet radix bupleuri rhizome, sheet stone in step 4 Processing is dried in calamus rhizome, sheet rhizoma alismatis stem tuber, sheet tuber of pinellia stem tuber, sheet dried immature fruit of citron orange young fruit and sheet radix glycyrrhizae rhizome;Step 6:Mixing;By obtained dry sheet hawthorn, dry block Poria cocos, dry strip dried orange peel, dry sheet in step 5 Radix bupleuri rhizome, sheet root of Rhizoma Acori Graminei stem is dried, sheet rhizoma alismatis stem tuber is dried, dries sheet tuber of pinellia stem tuber, dries sheet dried immature fruit of citron orange children Fruit and dry sheet licorice stem, are uniformly mixed according to the weight proportion described in claim 1;Step 7:Sterilization;Obtained tablet mixture in step 6 is subjected to sterilization processing, and according to the weight described in claim 6 Amount proportioning carries out packing processes.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109394985A (en) * | 2018-11-30 | 2019-03-01 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | Soothing the liver Wendan Tang with dispersing stagnated hepatoqi, dissipating phlegm and removing blood stasis effect |
CN110013512A (en) * | 2019-04-22 | 2019-07-16 | 李世辉 | A kind of Chinese medicine composition and preparation method thereof for treating cardio-cerebral diseases |
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