CN103768376B - A kind of composition of medicine treating diabetes and preparation method - Google Patents
A kind of composition of medicine treating diabetes and preparation method Download PDFInfo
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- CN103768376B CN103768376B CN201310325162.8A CN201310325162A CN103768376B CN 103768376 B CN103768376 B CN 103768376B CN 201310325162 A CN201310325162 A CN 201310325162A CN 103768376 B CN103768376 B CN 103768376B
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Abstract
A kind of composition of medicine treating diabetes and preparation method, it consists of Radix Ilicis Pubescentis 20-60 gram, wild ginseng 20-60 gram, Radix Scutellariae 10-20 gram, Cortex Phellodendri 10-20 gram, Rhizoma Coptidis 10-20 gram, Radix Astragali 10-15 gram, Radix Trichosanthis 10-15 gram, 10-30 gram of the Radix Rehmanniae, Cortex Acanthopancis 10-15 gram, Radix Ophiopogonis 10-15 gram are restrained into Radix Glycyrrhizae 8-10.Its preparation technology is, said medicine is weighed by formula, all crude drug are ground into coarse powder, raw material medicated powder is steeped 1 hour by the rare alcohol immersion containing 40% ethanol, heat with the rare alcohol liquid containing 40% ethanol again, the liquid level keeping rare alcohol liquid is consistently higher than raw material medicated powder, temperature is maintained at 60-80 degree, extracts 4 hours, extracts three times continuously, concentration extraction medicinal liquid, reclaim ethanol, following pharmaceutical procedures, it is possible to conventionally oral dosage form operation carries out simultaneously, the oral solid formulation prepared amounts to into the total amount of crude drug, and every day is no less than 21 grams of crude drug amounts.Coordinating the decocting liquid with Ganoderma, Rhizoma Dioscoreae equivalent again is priming, takes this medicine.It within 30 days, it is a course for the treatment of.Taking three courses for the treatment of continuously, curative effect reaches more than 95%.
Description
Technical field: the present invention a kind of utilizes natural plant compatible combination under the theory of Chinese medical science rule for the treatment of instructs to form medicine and preparation method thereof for the treatment of diabetes.
Background technology: diabetes are referred to as to quench one's thirst in the theoretical rule for the treatment of of Traditional Chinese Medicine, has another name called yearningly, disappears.After Song, unit, there are again title three persons of disappearing, refer to the disease being feature with polydipsia, polyphagia, polyuria symptom, how because of surfeit delicious food, improper diet, or disorder of emotion, work and rest mistake degree, cause that internal organs are scorching, caused by hyperactivity of fire caused by deficiency of YIN.Therapeutic Principle generally based on YIN nourishing, moisturize, pathogenic fire reducing, according to the developmental stage of the state of an illness, disappear on having, in disappear, under disappear not.The feature course of disease of this disease is long, expendable figure, and the mental status is subject to great puzzlement, there is no again the medicine that can cure completely at present, so, explore and excavate the medical treasure-house of Traditional Chinese Medicine, research and develop the medicine of new treatment diabetes, benefit the people, be also our obligation and responsibility.
Summary of the invention: it is an object of the invention to open one and utilize natural plant that diabetes are had medicative composition of medicine, the combination of its compatibility of drugs is according to Chinese tradition theory of Chinese medical science, the medicine of compatibility composition to the disease performance of the understanding of diabetes and clinical patient and the generation of diabetic syndrome thereof, reaches the purpose for the treatment of diabetes and syndrome thereof.
The present invention also aims to provide described composition of medicine, prepare into and facilitate patient to use, reach the preparation method that its composition of medicine plays the oral formulations of best biopotency.
The each component of composition of medicine of the present invention has good therapeutic effect in following weight range,
Radix Ilicis Pubescentis 20-60, wild ginseng 20-60, Radix Scutellariae 10-20, Cortex Phellodendri 10-20, Rhizoma Coptidis 10-20, Radix Astragali 10-15, Radix Trichosanthis 10-15, Radix Rehmanniae 10-30, Cortex Acanthopancis 10-15, Radix Ophiopogonis 10-15, Radix Glycyrrhizae 8-10.
It is preferably: Radix Ilicis Pubescentis 20, wild ginseng 20, Radix Scutellariae 15, Cortex Phellodendri 15, Rhizoma Coptidis 15, the Radix Astragali 12, Radix Trichosanthis 10, the Radix Rehmanniae 15, Cortex Acanthopancis 12, Radix Ophiopogonis 12, Radix Glycyrrhizae 8；
The best consists of: Radix Ilicis Pubescentis 50, wild ginseng 50, Radix Scutellariae 12, Cortex Phellodendri 12, Rhizoma Coptidis 12, the Radix Astragali 12, Radix Trichosanthis 12, the Radix Rehmanniae 15, Cortex Acanthopancis 12, Radix Ophiopogonis 12, Radix Glycyrrhizae 10.
For consumption per capita, the unit of above-mentioned composition is gram.
The preparation technology of the present invention is: said medicine weighed by combination formula amount, all crude drug are ground into coarse powder 40-60 order, raw material medicated powder is steeped 1 hour by the rare alcohol immersion containing 40% ethanol, the liquid level keeping rare alcohol liquid is consistently higher than raw material medicated powder 2-5 centimetre, temperature is maintained at 60-80 degree, extract 4 hours, extract three times continuously, concentration extraction medicinal liquid, reclaim ethanol, following pharmaceutical procedures, it is possible to conventionally oral dosage form operation carries out simultaneously, both sugar free granule, concentration drop pill can have been made, it is also possible to make the various dosage form of the oral administration solids such as tablet.The patient benefiting diabetes uses, and releases their misery, cures their disease, recovers the ego behavior ability that they are good, improve the quality of life of oneself.
The composition of medicine consumption of the present invention is: every day three times, each 7 grams, be equivalent to primary dose, can be priming with the decocting liquid of Ganoderma, Rhizoma Dioscoreae equivalent, take this medicine when taking medicine.It within 30 days, it is a course for the treatment of.Taking three courses for the treatment of continuously, curative effect reaches more than 95%.
The main remarkable result of the present invention:
1. this pharmaceutical composition is based on secret recipe handed down in the familyization sanction, proves successful in every test, and its effect is very good.
2. determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, careful prescription, nourishing YIN and clearing away heat, blood enriching and dryness moistening, drop and quench one's thirst clearly, nontoxic, safety.
3. heat-clearing and toxic substances removing, penetrating venation, removing obstruction for relieving pain, high sugar gangrene disease is had treatment and Healing preferably.
4. production process is easy, easy to implement the method, quality controllable, and dosage form suitable patient take.
The main component of each component of composition of medicine of the present invention includes:
Radix Ilicis Pubescentis: for the root of Aquifoliaceae Radix Ilicis Pubescentis IlexpubescensHook.etAyn., containing compositions such as flavonoid glycoside, phenolic constituent, sterol, tannin, triterpeness in its root.Hardship, flat.Blood circulation and channel invigorating, heat-clearing and toxic substances removing.
Wild ginseng is the root of Araliaceae Radix Ginseng (PanaxginsengC.A.Mey), invigorating QI to relieve exhaustion, tonifying the lung strengthening the spleen, promotes the production of body fluid, calms the nerves.Containing ginsenoside, volatile oil, Panaxynol, choline and multivitamin and panose.Righting, raising immunity of organisms, reduce blood glucose and can work in coordination with the metabolic function of islets of langerhans, playing the function of strengthening the body resistance, balance coordination body.
Radix Scutellariae: for the root of labiate Radix Scutellariae (ScutellariabaicalensisGeorgi), bitter, cold, enter the heart, stomach, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Containing compositions such as alkaloid, 13-methyl-.psi.-coptisine., berberine.
Cortex Phellodendri is the bark of rutaceae Cortex Phellodendri PhellodendronamurenseRupr. or wampee P.chinenseSchneid., bitter, cold, enters kidney, bladder, large intestine channel.Pathogenic fire purging, dampness, removing toxic substances.This product is containing berberine, phellodendrine etc..
Rhizoma Coptidis: for ranunculaceae plant Rhizoma Coptidis CoptischinensisFranch. and the rhizome belonging to several plants together.Bitter, cold.Enter the heart, stomach, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.This product is containing berberine, 13-methyl-.psi.-coptisine. etc..
The Radix Astragali: for the root of leguminous plant Radix Astragali Astragalusmembranaceus (Fisch.) Bunge or astragalus mongholicus Bge A.mongholicusBunge etc..Sweet, tepor.Enter spleen, lung meridian, invigorating the spleen and replenishing QI, consolidating superficial resistance, diuretic, pus expelling by strengthening vital QI, granulation promoting.Astragalus root contains choline, glycine betaine, coumarin, chromocor compound, Saponin, aminoacid etc., and Inner Mongolia Astragalis contains flavonoid glycoside, and aglycon has Quercetin, isorhamnetin etc..The immunity of Radix Astragali energy enhancing body and the effect of nonspecific immunity.
Radix Trichosanthis, calls radices trichosanthis, Lou Gen.Root for cucurbitaceous plant Fructus Trichosanthis TrichosantheskirilowiiMaxim..Hardship sweet, micro-, acid, be slightly cold.Enter lung, stomach warp.Can promoting the production of body fluid to quench thirst, clearing away lung-heat and moistening for dryness, change in the heart dry phlegm, peaceful lung cough-relieving, clearing away heat and promoting production of body fluid, pathogenic fire reducing is moisturized, and evacuation of pus is subsided a swelling, and controls lung-heat type cough, the disease such as calentura is thirsty, quench one's thirst, jaundice.This product effective ingredient is trichosanthin, for the mixture of multiple proteins.
Radix Rehmanniae: the another name Radix Rehmanniae, dry Radix Rehmanniae.Dry rhizome for scrophulariaceae rehmannia glutinosa plant Rehmanniaglutinosa (Gaertn.) Libosch. or bosom celebrating Radix Rehmanniae R.glutinosaLibosch.F.hueichingensis (ChaoetSchih.) Hsiao.Sweet, bitter, cool in nature.Enter the heart, liver, kidney channel.The rich gas of this product is thin, the special nourishing YIN and clearing away heat of merit, blood enriching and dryness moistening, cooling blood for hemostasis, promoting the production of body fluid to quench thirst, control epidemic febrile disease heating, crimson tongue thirsty, fever due to yin deficiency, quench one's thirst, haematemesis etc., Radix Rehmanniae contained humidity is less, nourishing YIN and benefiting blood merit is, the rhizome of Radix Rehmanniae and bosom celebrating Radix Rehmanniae is all containing mannitol, catalpol, saccharide and arginine etc., and Radix Rehmanniae contains rehmanin, alkaloid etc.
Cortex Acanthopancis: for the root bark of Araliaceae slender acanthopanax AcanthopanaxgracilistylusW.W.Smith or Cortex Acanthopancis A.sessiflorusSeem. etc..Pungent, temperature.Enter liver, kidney channel.Wind-damp dispelling, bone and muscle strengthening.Slender acanthopanax root bark contains volatile oil, tannin etc., and Cortex Acanthopancis root bark is containing multiple Cortex Acanthopancis glycosides and cardiac glycoside, volatilization wet goods.Radix Et Caulis Acanthopanacis Senticosi Acanthopanaxsenticosus (Rupr.etMaxim.) Harms root bark is containing multiple Radix Et Caulis Acanthopanacis Senticosi glucoside etc..
Radix Ophiopogonis: another name Radix Ophiopogonis, Radix Ophiopogonis.Tuber for liliaceous plant dwarf lilyturf OphiopogonjaponicusKer-Gawl..Hardship sweet, micro-, cold.Enter the heart, lung, stomach warp.Clearing away heart-fire and moistening the lung, nourishing the stomach to promote the production of body fluid.This product is containing multiple dwarf lilyturf glycosides, also containing B-sitosterol and glucoside thereof, stigmasterol etc..
Radix Glycyrrhizae: another name Radix Glycyrrhizae.Root and rhizome for glycyrrhizic legume GlycyrrhizauralensisFisch..Sweet, flat.Enter spleen, lung meridian.Spleen reinforcing stomach function regulating, relieving spasm to stop pain, expelling phlegm for arresting cough, removing toxic substances, coordinating the actions of various ingredients in a prescription.This product contains glycyrrhizic acid, enoxolone.
The pharmaceutical composition combined by natural plant above, the dialectical principle treated according to Chinese traditional medicine, it is possible to play YIN nourishing, promote the production of body fluid, nourishing the stomach, lung heat clearing, strengthening the body resistance, tonification takes off admittedly, tonifying the lung strengthening the spleen, comprehensively play blood pressure lowering, blood sugar lowering, blood fat reducing etc. and regulate the effect of organism balance, strengthening the body resistance, thus reaching to suppress, regulate blood glucose effect, reaching to control generation and the development of its complication simultaneously, reaching the purpose for the treatment of diabetes.
The side of composition of medicine prescription of the present invention solves:
Admittedly de-, the tonifying the lung strengthening the spleen with the tonification that Radix Ilicis Pubescentis, wild ginseng are monarch, promotes the production of body fluid, blood circulation and channel invigorating, heat-clearing and toxic substances removing, and penetrating venation improves immunity of organisms, and can work in coordination with and improve the metabolic function of insulin.
With Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, for minister, rushing down clearly the fiery and damp and hot of three Jiao, Rhizoma Coptidis is apt to into the heart with heat clearing away, can with bitter dampness, with cold antipyretic.Radix Scutellariae, bitter in the mouth is cool in nature, and kind clearing away lung-heat is through the warm of edema caused by disorder of QI, lower logical three burnt by spleen, reach in bladder with diuresis, be apt to again into taste heat clearing away, be good at into liver and gall heat clearing away, treatment few sun alternate attack of chill and fever, no matter any internal organs, its stagnation of QI and make hot person all can declare logical it, main quench one's thirst, have no side effect.
Help with the Radix Astragali, Cortex Acanthopancis, pollen, the Radix Rehmanniae, Radix Ophiopogonis be QI invigorating, YIN nourishing, promote the production of body fluid, nourishing the stomach lung heat clearing, with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, to help the performance of the property of medicine of the monarch and his subjects so that it is overall prescription reaches one and is suitable for prescription that the crowd of quenching one's thirst is suitable for and the prescription that the diabetic population patient that modern medical diagnosis is is suitable for.Can be priming with the decocting liquid of Ganoderma, Rhizoma Dioscoreae equivalent when taking this medicine, take this medicine, reach good adjuvant treatment effect.The pharmacology of composition of medicine prescription of the present invention, acute toxicity test, have no toxic reaction, only maximum tolerated dose.
Detailed description of the invention
Embodiment 1,
In units of 1000 consumptions, essence amount weighs crude drug in whole, Radix Ilicis Pubescentis 20, wild ginseng 20, Radix Scutellariae 15, Cortex Phellodendri 15, Rhizoma Coptidis 15, the Radix Astragali 12, Radix Trichosanthis 10, the Radix Rehmanniae 15, Cortex Acanthopancis 12, Radix Ophiopogonis 12, Radix Glycyrrhizae 8.Weigh crude drug in whole according to prescription proportioning, to obtain 1000 grams of consumptions for radix, above-mentioned crude drug in whole is pulverized, cross 100 mesh sieves, make fine powder, it is possible to traditionally Chinese kmedicine bolus manufacture technology program makes the watered pill.Co 60 sterilizing, is finished product.
Instructions of taking: every day three times, is priming with the decocting liquid of Ganoderma, Rhizoma Dioscoreae equivalent, takes this medicine by each 7 grams.It within 30 days, it is a course for the treatment of.Taking three courses for the treatment of continuously, curative effect reaches more than 95%.
Embodiment 2,
In units of 1000 consumptions, essence amount weighs best of breed recipe quantity crude drug in whole, Radix Ilicis Pubescentis 50 grams, wild ginseng 50 grams, Radix Scutellariae 12 grams, Cortex Phellodendri 12 grams, Rhizoma Coptidis 12 grams, the Radix Astragali 12 grams, Radix Trichosanthis 12 grams, 15 grams of the Radix Rehmanniae, Cortex Acanthopancis 12 grams, Radix Ophiopogonis 12 grams, 10 grams of Radix Glycyrrhizae.All protogenic medicinal powder are broken into coarse powder, steep raw material medicated powder 1 hour by the rare alcohol immersion containing 40% ethanol, keep the liquid level of rare alcohol liquid to be consistently higher than raw material medicated powder, temperature is maintained at 60-80 degree, extracts 4 hours, extracts three times continuously, concentration extraction medicinal liquid, reclaim ethanol, following pharmaceutical procedures, its technological operation step simultaneously, can conventionally oral dosage form operation carry out, both sugar free granule can have been made, it is also possible to make concentration drop pill, it is also possible to make the solid oral dosage forms such as tablet.The oral solid formulation prepared amounts to into the total amount of crude drug, and every day, no less than 21 grams of crude drug amounts, point takes for three times, then to coordinate the decocting liquid with Ganoderma, Rhizoma Dioscoreae equivalent be priming, takes this medicine.It within 30 days, it is a course for the treatment of.Taking three courses for the treatment of continuously, curative effect reaches more than 95%.
Pharmaceutical composition of the present invention is based on secret recipe handed down in the familyization and cuts out, and proves successful in every test, and its effect is very good.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, careful prescription, nourishing YIN and clearing away heat, blood enriching and dryness moistening, drop and quench one's thirst clearly, nontoxic, safety.Heat-clearing and toxic substances removing, penetrating venation, removing obstruction for relieving pain, high sugar gangrene disease is had treatment and Healing preferably.Its production process is easy, easy to implement the method, quality controllable, and the suitable diabetics of dosage form is taken, and releases their misery, cures their disease, recovers and improve the autonomous quality of life of diabetics.
Claims (3)
1. the composition of medicine treating diabetes, it is characterised in that: it is restrained into Radix Glycyrrhizae 8-10 by Radix Ilicis Pubescentis 20-60 gram, wild ginseng 20-60 gram, Radix Scutellariae 10-20 gram, Cortex Phellodendri 10-20 gram, Rhizoma Coptidis 10-20 gram, Radix Astragali 10-15 gram, Radix Trichosanthis 10-15 gram, 10-30 gram of the Radix Rehmanniae, Cortex Acanthopancis 10-15 gram, Radix Ophiopogonis 10-15 gram.
2. treat the composition of medicine of diabetes according to claim 1, it is characterised in that: it is restrained into by Radix Ilicis Pubescentis 50 grams, wild ginseng 50 grams, Radix Scutellariae 12 grams, Cortex Phellodendri 12 grams, Rhizoma Coptidis 12 grams, the Radix Astragali 12 grams, Radix Trichosanthis 12 grams, 15 grams of the Radix Rehmanniae, Cortex Acanthopancis 12 grams, Radix Ophiopogonis 12 grams, Radix Glycyrrhizae 10.
3. the preparation method of the composition of medicine for the treatment of diabetes according to claim 1 or claim 2, it is characterised in that: weighed according to recipe quantity by crude drug in whole, pulverize, rare alcohol extraction, concentration, extractum make granule, concentrated pill or tablet or other solid orally ingestibles according still further to solid oral dosage form technique.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1243006A (en) * | 1999-07-07 | 2000-02-02 | 陈大明 | Chinese medicine preparation for treating diabetes |
| CN101284015A (en) * | 2008-05-05 | 2008-10-15 | 济南康众医药科技开发有限公司 | Medicine for treating diabetes and production method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1243006A (en) * | 1999-07-07 | 2000-02-02 | 陈大明 | Chinese medicine preparation for treating diabetes |
| CN101284015A (en) * | 2008-05-05 | 2008-10-15 | 济南康众医药科技开发有限公司 | Medicine for treating diabetes and production method thereof |
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