CN113786464A - Traditional Chinese medicine composition for treating chicken pox and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chicken pox and preparation method thereof Download PDFInfo
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- CN113786464A CN113786464A CN202111278320.XA CN202111278320A CN113786464A CN 113786464 A CN113786464 A CN 113786464A CN 202111278320 A CN202111278320 A CN 202111278320A CN 113786464 A CN113786464 A CN 113786464A
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Abstract
The invention provides a traditional Chinese medicine composition for treating varicella and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating varicella comprises, by weight, 80-100 parts of dandelion, 30-60 parts of caltrop, 40-60 parts of cortex dictamni, 20-30 parts of fructus viticis, 15-35 parts of butterflybush flower, 10-20 parts of radix ophiopogonis, 12-18 parts of water chestnut, 10-30 parts of mulberry leaves, 15-25 parts of selfheal, 10-15 parts of liquorice, 15-25 parts of mint and 15-30 parts of lophatherum gracile. The invention also provides a preparation method of the traditional Chinese medicine composition for treating varicella. The traditional Chinese medicine composition for treating chicken pox has the advantages that the traditional Chinese medicine composition can effectively treat the chicken pox in children, has no scar residue after healing, small irritation, safety and no toxicity, can effectively extract beneficial components in the raw materials by classifying and preparing the raw materials, and is simple in preparation method and convenient to popularize.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating varicella and a preparation method thereof.
Background
Varicella is caused by herpes virus, is a common acute eruptive infectious disease for children, is clinically characterized by fever, pruritic spots, hills, herpes and scabs in batches on skin mucous membranes, can simultaneously appear, and is named as varicella because the herpes is bright and oval. Varicella and herpes zoster are both infectious sources, the varicella is more infectious, the incubation period is 10-21 days, viruses disappear after scabbing, and the infection period is from 24 hours before purple eruption to scabbing of the lesion, and is 7-8 days. The disease has strong infectivity, the incidence rate of children can reach 95 percent, the epidemic is very easy to cause, the disease can occur all the year round, the disease is sporadic in two seasons of winter and spring, and the incidence age is 6-9 years old.
At present, the varicella is mainly treated by antivirus, for example, acyclovir and the like are used for treatment, the antiviral effect is achieved by inhibiting the synthesis of virus DNA, other western medicines are also widely used for treating the varicella, the treatment mode has side effects of inflammation or phlebitis, skin itch or urticaria and the like at an injection part, the treatment mode cannot change the internal environment of a patient, the symptoms are treated, the root causes are not treated, and certain limitation is brought to the treatment of the varicella. The traditional Chinese medicine considers that the chicken pox is caused by the fact that chicken pox seasonal pathogenic viruses enter from the mouth and the nose, and the chicken pox is divided into two types of symptoms of wind-heat type and toxic-heat type. Patients with wind-heat type are mild in disease condition, with the clinical manifestations of fever, clear and bright blister, sparse distribution, mild pruritus, lassitude, red tongue with white coating and floating and rapid pulse, and for treatment, the herbs of dispelling wind and clearing heat are mainly added and subtracted with Yinqiao powder. The clinical manifestations of severe disease of patients with toxic-heat type are high fever, dense pox eruptions, turbid pox pulp, thirst, dry lips, listlessness, deep-red tongue, yellow tongue coating and surging and rapid pulse, and for treatment, heat-clearing, toxicity-removing and blood-cooling are the main reasons, and the recipe is modified with Qingying decoction. Therefore, there is a need to develop a varicella treatment formulation suitable for the current social situation from the viewpoint of the traditional Chinese medicine.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating chicken pox, which can effectively treat the chicken pox in children, has no scar residue after healing, small irritation, safety and no toxicity.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating the chicken pox, which is characterized in that the raw materials are classified and prepared, so that the beneficial ingredients in the raw materials can be effectively extracted, and the preparation method is simple and convenient to popularize.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On the one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating varicella, which comprises 80-100 parts by weight of dandelion, 30-60 parts by weight of tribulus terrestris, 40-60 parts by weight of cortex dictamni, 20-30 parts by weight of fructus viticis, 15-35 parts by weight of butterflybush flower, 10-20 parts by weight of radix ophiopogonis, 12-18 parts by weight of water chestnut, 10-30 parts by weight of mulberry leaf, 15-25 parts by weight of selfheal, 10-15 parts by weight of liquorice, 15-25 parts by weight of mint and 15-30 parts by weight of lophatherum gracile.
On the other hand, the embodiment of the present application provides a preparation method of the aforementioned traditional Chinese medicine composition for treating varicella, which comprises the following steps: crushing caltrop, cortex dictamni, fructus viticis, radix ophiopogonis and liquorice, and decocting to obtain a first decoction; soaking dandelion, butterflybush flower, mulberry leaf, selfheal, mint and lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction; mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste; dissolving the concentrated paste in the second component, adding the third component and fresh water chestnut juice to obtain a mixed solution, finally adding a paste forming agent, and uniformly mixing to obtain the traditional Chinese medicine composition.
In summary, compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:
the traditional Chinese medicine composition for treating varicella provided by the invention is prepared from dandelion, selfheal, caltrop, cortex dictamni and water chestnut, and has the effects of clearing heat and removing toxicity, relieving swelling and resolving masses, and relieving itching and removing toxicity; fructus viticis, flos buddlejae, folium mori and lophatherum gracile have the effects of clearing heat and purging fire, dispelling wind and heat, inducing diuresis for treating stranguria, clearing lung-heat and moistening dryness, facilitating the response to fever symptoms when varicella appears, reducing fever time and the highest fever temperature, and reducing the side effects of the disease; the mint can disperse wind and heat, promote eruption and facilitate the acceleration of varicella virus to fully distribute on the body surface, namely potential varicella to be developed can be developed on the body surface as soon as possible, thus facilitating the treatment and shortening of the course of treatment; meanwhile, the ophiopogon root is used for nourishing yin and promoting the production of body fluid, moistening lung and clearing away heart-fire, the liquorice is used for tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. Through the effective compatibility of the raw materials, the treatment time can be obviously shortened, scars left after the varicella is healed can be avoided, the irritation is small, and the medicine is safe and non-toxic.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating the chicken pox, the preparation method of the traditional Chinese medicine composition for treating the chicken pox can effectively extract beneficial components in the raw materials by classifying and preparing the raw materials, and meanwhile, the preparation method is simple and convenient to popularize.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
On the one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating varicella, which comprises 80-100 parts by weight of dandelion, 30-60 parts by weight of tribulus terrestris, 40-60 parts by weight of cortex dictamni, 20-30 parts by weight of fructus viticis, 15-35 parts by weight of butterflybush flower, 10-20 parts by weight of radix ophiopogonis, 12-18 parts by weight of water chestnut, 10-30 parts by weight of mulberry leaf, 15-25 parts by weight of selfheal, 10-15 parts by weight of liquorice, 15-25 parts by weight of mint and 15-30 parts by weight of lophatherum gracile.
Dandelion: is dried whole plant of Taraxacum mongolicum hand-Mazz, Taraxacum borealisinsens Kitam, or plants of the same genus. Digging when the flower is primarily opened from spring to autumn, removing impurities, cleaning, and drying in the sun. Bitter, sweet and cold. It enters liver and stomach meridians. Clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with astringency and pain due to heat.
Caltrop fruit: is dried mature fruit of Tribulus terrestris L. Harvesting plants when fruit is mature in autumn, drying in the sun, digging down the fruit, and removing impurities. Pungent, bitter and slightly warm; has little toxicity. It enters liver meridian. Calming the liver, relieving depression, promoting blood circulation, expelling pathogenic wind, improving eyesight, and relieving itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus.
And (3) preparing cortex dictamni: is dried root bark of Dictamnus dasycarpus Turcz. Digging root in spring and autumn, removing silt and rough bark, stripping root bark, and drying. Bitter and cold. It enters spleen, stomach and bladder meridians. Clear heat and dry dampness, dispel wind and remove toxicity. Can be used for treating damp-heat sore, yellow water dripping, eczema, rubella, scabies, sore, rheumatism, heat arthralgia, jaundice, and dark urine.
Chastetree fruit: is dried mature fruit of Vitex trifoliata L.var. simplicifolia or Vitex trifolia L.of Verbenaceae. Collected in autumn when the fruit is ripe, removed of impurities and dried in the sun. Pungent, bitter and slightly cold. It enters bladder, liver and stomach meridians. Disperse wind-heat, clear head and eyes. Can be used for treating wind-heat type common cold, headache, gingival swelling and pain, conjunctival congestion, hyperdacryosis, dim and unclear vision, and dizziness.
Butterflybush flower: is dried bud and inflorescence of Buddleja officinalis Maxim. Harvesting in spring when the flower is not opened, removing impurities, and drying. Sweet and slightly cold. It enters liver meridian. Clear heat and purge fire, nourish liver to improve vision, remove nebula. Can be used for treating conjunctival congestion, swelling and pain, lacrimation, photophobia, nebula, liver deficiency, dim eyesight, and blurred vision.
Radix ophiopogonis: is dried root tuber of Ophiopogon japonica (L.f) Ker-Gawl. of Liliaceae. Collected in summer, cleaned, repeatedly exposed to the sun, piled until the seven-eight dry, removed fibrous root, and dried. Sweet, slightly bitter and slightly cold. It enters heart, lung and stomach meridians. Nourish yin, promote the production of body fluid, moisten lung and clear away heart-fire. Can be used for treating lung dryness, dry cough, yin deficiency, tuberculosis, sore throat, body fluid consumption, thirst, internal heat, vexation, insomnia, and constipation.
Water chestnut: also called as water chestnut, combined yam, linden, etc., belongs to the family of monocotyledonous cyperaceae and is a perennial herbaceous plant. Is cold in nature, has effects of clearing away heat and toxic materials, cooling blood, promoting salivation, promoting urination, relieving constipation, eliminating dampness, eliminating phlegm, resolving food stagnation, and relieving flatulence, and can be used for treating jaundice, dysentery, poliomyelitis, constipation, etc.; the water chestnut contains an antibacterial component, has a certain effect of reducing blood pressure, and has a function of preventing and treating cancers.
Mulberry leaf: is dried leaf of Morus albal. After blooming, harvesting, removing impurities and drying in the sun. Sweet, bitter and cold. It enters lung and liver meridians. Disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight.
Selfheal: is dried fruit cluster of Prunella vulgaris L.of Labiatae family. Harvesting in summer when the fruit cluster is brownish red, removing impurities, and drying in the sun. Pungent, bitter and cold. It enters liver and gallbladder meridians. Clear liver-fire, improve vision, dissipate nodulation and relieve swelling. Can be used for treating conjunctival congestion, swelling and pain, eye bead nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, mammary nodules, and breast pain.
Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Collected in spring and autumn, removed fibrous root, and dried in the sun. Sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Mint: is dried aerial parts of Mentha haplocalyx Briq. of Labiatae. When stems and leaves flourish or flowers bloom to three rounds in summer and autumn, the plants are harvested and cut in parts on a sunny day, and dried in the sun or in the shade. Pungent and cool. It enters lung and liver meridians. Disperse wind-heat, clear heat and improve eyesight, relieve sore throat, promote eruption, soothe liver and move qi. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling.
Herba lophatheri: is dried stem and leaf of Lophatherum gracile Brongn of Gramineae. Harvesting before flower spike is removed in summer, and sun drying. Sweet, bland and cold. It enters heart, stomach and small intestine meridians. Clear heat and purge fire, relieve restlessness and quench thirst, induce diuresis and treat stranguria. Can be used for treating fever, polydipsia, scanty and painful urine, and aphtha of the mouth and tongue.
In some embodiments of the present invention, the traditional Chinese medicine composition for treating varicella comprises, by weight, 90 parts of dandelion, 45 parts of tribulus terrestris, 50 parts of cortex dictamni, 25 parts of fructus viticis, 20 parts of butterflybush flower, 15 parts of radix ophiopogonis, 15 parts of water chestnut, 20 parts of folium mori, 20 parts of prunella vulgaris, 12 parts of liquorice, 20 parts of mint and 20 parts of lophatherum gracile.
In some embodiments of the invention, the traditional Chinese medicine composition for treating varicella comprises, by weight, 20-40 parts of wheat seedlings, 5-10 parts of ginger and 20-50 parts of water.
In some embodiments of the invention, the traditional Chinese medicine composition for treating varicella further comprises a third component, and the third component further comprises 5-15 parts by weight of zanthoxylum oil and 10-20 parts by weight of peppermint oil.
In some embodiments of the present invention, the traditional Chinese medicine composition for treating varicella further comprises an ointment forming agent, and the ointment forming agent comprises raw oyster powder and talcum powder.
In some embodiments of the present invention, in the traditional Chinese medicine composition for treating varicella, the weight ratio of the raw oyster powder to the talcum powder is 1:1.
On the other hand, the embodiment of the present application provides a preparation method of the aforementioned traditional Chinese medicine composition for treating varicella, which comprises the following steps: crushing caltrop, cortex dictamni, fructus viticis, radix ophiopogonis and liquorice, and decocting to obtain a first decoction; soaking dandelion, butterflybush flower, mulberry leaf, selfheal, mint and lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction; mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste; dissolving the concentrated paste in the second component, adding the third component and fresh water chestnut juice to obtain a mixed solution, finally adding a paste forming agent, and uniformly mixing to obtain the traditional Chinese medicine composition.
In some embodiments of the present invention, in the preparation method of the traditional Chinese medicine composition for treating varicella, the second component is prepared by taking fresh wheat seedlings and ginger, cleaning, and decocting with water for 20-40 minutes until the weight parts of the wheat seedlings, the weight parts of the ginger and the water are 20-50.
In some embodiments of the invention, in the above preparation method of the traditional Chinese medicine composition for treating varicella, the temperature of the mixed solution is not more than 40 ℃ in the process of adding the third component, the fresh water chestnut juice and the paste forming agent.
In some embodiments of the invention, in the preparation method of the traditional Chinese medicine composition for treating varicella, the mass ratio of the ointment forming agent to the mixed solution is (1-1.5): 1.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment aims to provide a traditional Chinese medicine composition for treating varicella, which is prepared by the following steps:
the method comprises the following steps: crushing 30g of caltrop, 50g of cortex dictamni, 20g of fructus viticis, 10g of radix ophiopogonis and 10g of liquorice, and decocting to obtain a first decoction;
step two: soaking 95g of dandelion, 15g of butterflybush flower, 10g of mulberry leaf, 25g of selfheal, 15g of mint and 25g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 30g of fresh wheat seedlings and 5g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 20g, so as to obtain a second component;
step five: juicing 12g of water chestnut by using a juicer, and filtering by using a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (5 g of zanthoxylum oil and 12g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Example 2
The embodiment aims to provide a traditional Chinese medicine composition for treating varicella, which is prepared by the following steps:
the method comprises the following steps: crushing 40g of caltrop, 40g of cortex dictamni, 22g of fructus viticis, 12g of radix ophiopogonis and 12g of liquorice, and decocting to obtain a first decoction;
step two: soaking 85g of dandelion, 35g of butterflybush flower, 12g of mulberry leaf, 15g of selfheal, 18g of mint and 30g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 35g of fresh wheat seedlings and 6g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 30g, so as to obtain a second component;
step five: squeezing 15g of water chestnuts by using a juicer, and then filtering the juice through a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (8 g of zanthoxylum oil and 18g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1.5; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Example 3
The embodiment aims to provide a traditional Chinese medicine composition for treating varicella, which is prepared by the following steps:
the method comprises the following steps: crushing 50g of caltrop, 60g of cortex dictamni, 28g of fructus viticis, 20g of radix ophiopogonis and 15g of liquorice, and decocting to obtain a first decoction;
step two: soaking 100g of dandelion, 25g of butterflybush flower, 18g of mulberry leaf, 18g of selfheal, 20g of mint and 15g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 25g of fresh wheat seedlings and 7g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 40g, so as to obtain a second component;
step five: squeezing 18g of water chestnuts by using a juicer, and then filtering the juice with a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (12 g of zanthoxylum oil and 20g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1.5; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Example 4
The embodiment aims to provide a traditional Chinese medicine composition for treating varicella, which is prepared by the following steps:
the method comprises the following steps: crushing 60g of caltrop, 45g of cortex dictamni, 30g of fructus viticis, 18g of radix ophiopogonis and 10g of liquorice, and decocting to obtain a first decoction;
step two: soaking 90g of dandelion, 28g of butterflybush flower, 25g of mulberry leaf, 22g of selfheal, 23g of mint and 18g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 20g of fresh wheat seedlings and 10g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 50g, so as to obtain a second component;
step five: squeezing 16g of water chestnuts by using a juicer, and then filtering the juice by using a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (15 g of zanthoxylum oil and 15g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Example 5
The embodiment aims to provide a traditional Chinese medicine composition for treating varicella, which is prepared by the following steps:
the method comprises the following steps: crushing 45g of caltrop, 50g of cortex dictamni, 25g of fructus viticis, 15g of radix ophiopogonis and 12g of liquorice, and decocting to obtain a first decoction;
step two: soaking 90g of dandelion, 20g of butterflybush flower, 20g of mulberry leaf, 20g of selfheal, 20g of mint and 20g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 40g of fresh wheat seedlings and 8g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 40g, so as to obtain a second component;
step five: squeezing 15g of water chestnuts by using a juicer, and then filtering the juice through a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (10 g of zanthoxylum oil and 10g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1.2; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Comparative example 1
The traditional Chinese medicine composition for treating varicella provided by the comparative example is different from the traditional Chinese medicine composition provided by the example 5 in that the second component is not contained, and the second component is replaced by clear water:
the method comprises the following steps: crushing 45g of caltrop, 50g of cortex dictamni, 25g of fructus viticis, 15g of radix ophiopogonis and 12g of liquorice, and decocting to obtain a first decoction;
step two: soaking 90g of dandelion, 20g of butterflybush flower, 20g of mulberry leaf, 20g of selfheal, 20g of mint and 20g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: preparing 88g of clear water to obtain a second component;
step five: squeezing 15g of water chestnuts by using a juicer, and then filtering the juice through a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (10 g of zanthoxylum oil and 10g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1.2; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Comparative example 2
The traditional Chinese medicine composition for treating chicken pox provided by the comparative example is different from the traditional Chinese medicine composition in example 5 in that the traditional Chinese medicine composition does not contain a third component, and a second component is replaced by sesame oil:
the method comprises the following steps: crushing 45g of caltrop, 50g of cortex dictamni, 25g of fructus viticis, 15g of radix ophiopogonis and 12g of liquorice, and decocting to obtain a first decoction;
step two: soaking 90g of dandelion, 20g of butterflybush flower, 20g of mulberry leaf, 20g of selfheal, 20g of mint and 20g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 40g of fresh wheat seedlings and 8g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 40g, so as to obtain a second component;
step five: squeezing 15g of water chestnuts by using a juicer, and then filtering the juice through a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding 20g of sesame oil and fresh water chestnut juice to obtain a mixed solution, and finally adding a paste forming agent, wherein the mass ratio of the paste forming agent to the mixed solution is 1: 1.2; mixing uniformly to obtain the traditional Chinese medicine composition, and controlling the temperature of the solution not to exceed 40 ℃ in the process.
Comparative example 3
The traditional Chinese medicine composition for treating varicella provided by the comparative example is different from the traditional Chinese medicine composition provided by the example 5 in that the traditional Chinese medicine composition does not contain an ointment forming agent:
the method comprises the following steps: crushing 45g of caltrop, 50g of cortex dictamni, 25g of fructus viticis, 15g of radix ophiopogonis and 12g of liquorice, and decocting to obtain a first decoction;
step two: soaking 90g of dandelion, 20g of butterflybush flower, 20g of mulberry leaf, 20g of selfheal, 20g of mint and 20g of lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
step three: mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste;
step four: taking 40g of fresh wheat seedlings and 8g of ginger, cleaning, adding water, and decocting for 20-40 minutes until the water content is 40g, so as to obtain a second component;
step five: squeezing 15g of water chestnuts by using a juicer, and then filtering the juice through a 0.22 micron filter membrane to obtain fresh water chestnut juice;
step six: dissolving the concentrated paste in the second component, adding the third component (10 g of zanthoxylum oil and 10g of peppermint oil) and fresh water chestnut juice to obtain a mixed solution, and concentrating the mixed solution into paste, namely the traditional Chinese medicine composition for treating the chicken pox, wherein the temperature of the solution is controlled not to exceed 40 ℃.
Examples of effects
1. Drug allergy test
Preparing 6 rabbits with equal weight, unhairing the back of each rabbit, exposing 9 pieces of skin, each piece about 1.5cm2Numbered 1-9, wherein 1-8 correspond to the traditional Chinese medicine composition for treating varicella provided in examples 1-5 and comparative examples 1-3 in sequence, the total number of the tests is 21 days, No. 9 is coated with normal saline, and whether abnormal skin such as erythema, pruritus and edema appears at the coated part or not is observed every dayA condition.
The foregoing experimental results show that the composition for treating varicella provided in either the examples or the comparative examples is non-irritating.
2. Washing for treating varicella
Selecting 54 varicella sick children in total from 9 months in 2018 to 9 months in 2020, wherein family members know the conditions and sign a consent, and the sick children have no basic diseases seriously threatening life and are manifested as coexistence of papules, blisters and scabs. The drugs were randomly grouped, wherein 1 to 5 groups used the composition for treating varicella provided in examples 1 to 5, 6 to 8 groups used the composition for treating varicella provided in comparative examples 1 to 3, and 9 groups used the existing antiviral drugs for treating varicella, and 6 people per group. 1-8 groups were washed with water three times a day, and 9 groups were performed according to the current pharmaceutical instructions. Wherein, the degree of pruritus is the self description or the family members of the children patients, 5 is basically without itching feeling, and 1 is extremely itchy; the ease of administration is scored according to the self-use feeling of the infant or family members, the administration is easier and no difficult in 5 points, the administration is extremely difficult in 1 point, and the use results are as follows:
TABLE 1
| Group of | Time to scab rash (d) | Healing and efficacy | Degree of itching | Degree of ease of application |
| 1 | 5.83±1.20 | 100％ | 4.3 | 5.0 |
| 2 | 5.19±0.71 | 100％ | 4.3 | 5.0 |
| 3 | 5.54±0.82 | 100％ | 3.8 | 5.0 |
| 4 | 5.35±1.13 | 100％ | 4.1 | 5.0 |
| 5 | 5.16±0.49 | 100％ | 4.5 | 5.0 |
| 6 | 6.02±1.46 | 100％ | 3.8 | 5.0 |
| 7 | 6.11±1.28 | 100％ | 3.5 | 5.0 |
| 8 | 5.98±1.19 | 100％ | 4.1 | 3.6 |
| 9 | 6.82±0.58 | 100％ | 2.3 | 3.5 |
As can be seen from table 1, the composition for treating varicella provided by the invention can obtain a better treatment effect by reasonably matching dandelion, puncturevine caltrop fruit, cortex dictamni, fructus viticis, butterflybush flower, radix ophiopogonis, water chestnut, mulberry leaf, selfheal, liquorice, mint and lophatherum gracile, and can significantly improve the use feeling of patients, reduce the itching feeling when the varicella appears, shorten the treatment time and improve the convenience degree of the medication of children by adding a certain second component, a certain third component and a paste forming agent.
In conclusion, the composition for treating varicella provided by the embodiment of the invention has the following beneficial effects:
the traditional Chinese medicine considers that the varicella is caused by damp-heat, so that the basic principle of clearing away heat and toxic materials and promoting diuresis is adopted in the treatment. In the formula, the dandelion, the selfheal, the caltrop, the dittany bark and the water chestnut clear away heat and toxic materials, reduce swelling, dissipate stagnation, relieve itching and remove toxicity; fructus viticis, flos buddlejae, folium mori and lophatherum gracile have the effects of clearing heat and purging fire, dispelling wind and heat, inducing diuresis for treating stranguria, clearing lung-heat and moistening dryness, facilitating the response to fever symptoms when varicella appears, reducing fever time and the highest fever temperature, and reducing the side effects of the disease; the mint can disperse wind and heat, promote eruption and facilitate the acceleration of varicella virus to fully distribute on the body surface, namely potential varicella to be developed can be developed on the body surface as soon as possible, thus facilitating the treatment and shortening of the course of treatment; meanwhile, the ophiopogon root is used for nourishing yin and promoting the production of body fluid, moistening lung and clearing away heart-fire, the liquorice is used for tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. Through the effective compatibility of the raw materials, the treatment time can be obviously shortened, and scars left after the varicella is healed can be avoided.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating varicella is characterized by comprising, by weight, 80-100 parts of dandelion, 30-60 parts of tribulus terrestris, 40-60 parts of cortex dictamni, 20-30 parts of fructus viticis, 15-35 parts of butterflybush flower, 10-20 parts of radix ophiopogonis, 12-18 parts of water chestnuts, 10-30 parts of mulberry leaves, 15-25 parts of selfheal, 10-15 parts of liquorice, 15-25 parts of mint and 15-30 parts of lophatherum gracile.
2. The traditional Chinese medicine composition for treating varicella according to claim 1, which comprises 90 parts by weight of dandelion, 45 parts by weight of tribulus terrestris, 50 parts by weight of cortex dictamni, 25 parts by weight of fructus viticis, 20 parts by weight of butterflybush flower, 15 parts by weight of radix ophiopogonis, 15 parts by weight of water chestnut, 20 parts by weight of mulberry leaf, 20 parts by weight of selfheal, 12 parts by weight of liquorice, 20 parts by weight of mint and 20 parts by weight of lophatherum gracile.
3. The traditional Chinese medicine composition for treating varicella according to claim 1, which comprises 20-40 parts by weight of wheat seedlings, 5-10 parts by weight of ginger and 20-50 parts by weight of water.
4. The traditional Chinese medicine composition for treating varicella according to claim 1, which further comprises a third component, wherein the third component further comprises 5-15 parts by weight of zanthoxylum oil and 10-20 parts by weight of peppermint oil.
5. The traditional Chinese medicine composition for treating varicella according to claim 1, which further comprises an ointment forming agent, wherein the ointment forming agent comprises raw oyster powder and talcum powder.
6. The traditional Chinese medicine composition for treating varicella according to claim 5, wherein the weight ratio of the raw oyster powder to the talcum powder is 1:1.
7. A method for preparing the traditional Chinese medicine composition for treating varicella according to claim 6, which comprises the following steps:
crushing caltrop, cortex dictamni, fructus viticis, radix ophiopogonis and liquorice, and decocting to obtain a first decoction;
soaking dandelion, butterflybush flower, mulberry leaf, selfheal, mint and lophatherum gracile, boiling with strong fire, and decocting for 0.5-1 h to obtain a second decoction;
mixing the first decoction and the second decoction, filtering to obtain filtrate, concentrating the filtrate in an external circulation concentrator, and concentrating at 0.03-0.05 Mpa and 65-70 ℃ until the relative density is 1.15-1.18 to obtain concentrated paste; dissolving the concentrated paste in the second component, adding the third component and fresh water chestnut juice to obtain a mixed solution, finally adding a paste forming agent, and uniformly mixing to obtain the traditional Chinese medicine composition.
8. The preparation method according to claim 7, wherein the second component is prepared by taking fresh wheat seedlings and ginger, washing, and decocting with water for 20-40 minutes until the weight parts of the wheat seedlings, the ginger and the water are 20-40 parts, 5-10 parts and 20-50 parts respectively.
9. The method of claim 7, wherein the temperature of the mixture does not exceed 40 ℃ during the addition of the third component, the fresh water chestnut juice and the paste forming agent.
10. The method according to claim 7, wherein the mass ratio of the paste forming agent to the mixed solution is (1-1.5): 1.
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