CN117695340A - Pharmaceutical composition for preventing and treating bacterial diseases of poultry and preparation method thereof - Google Patents
Pharmaceutical composition for preventing and treating bacterial diseases of poultry and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A pharmaceutical composition for preventing and treating bacterial diseases of poultry and a preparation method thereof belong to the technical field of pharmaceutical compositions, and comprise the following raw materials: radix Scutellariae, flos Lonicerae, radix Pulsatillae, herba Houttuyniae, cortex Phellodendri, rhizoma Coptidis, radix Isatidis, fructus forsythiae, herba Taraxaci, and radix Glycyrrhizae. The preparation method comprises the following steps: (1) Mixing the raw materials, decocting, filtering, and collecting filtrate and residue; (2) Crushing the filter residues, mixing the crushed filter residues with a microbial agent for fermentation, and then performing high-temperature sterilization treatment to obtain a fermentation product; (3) Concentrating the filtrate, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating bacterial diseases of poultry. According to the invention, medicines such as antibiotics are not required to be added, so that the medicine resistance of the poultry caused by excessive use of the antibiotics is avoided, and meanwhile, the edible safety of human beings to the poultry is ensured. In addition, the invention can further improve the utilization rate of the pharmaceutical composition by fermenting the filter residues after decoction.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical compositions, and particularly relates to a pharmaceutical composition for preventing and treating bacterial diseases of poultry and a preparation method thereof.
Background
In the poultry breeding process, disease prevention and treatment are very important, and bacterial infection, viral infection, parasitic infection diseases or even drug-induced liver injury diseases are in high incidence in breeding practice, wherein the bacterial diseases of the poultry mainly comprise fowl cholera, colibacillosis, salmonella, streptococcus, staphylococcosis, mycoplasma diseases and the like. The occurrence and evolution of the diseases, and various antibacterial drugs, antiparasitic drugs and antiviral drugs which are used in a large quantity in the prevention and treatment process, enhance the drug resistance of bacteria or parasites, and cause the problem that the diseases of poultry cannot be treated by common drugs. In addition, the antibiotics are too much used, and remain in the poultry body, so that the edible safety of human beings is affected.
Therefore, how to provide a pharmaceutical composition capable of avoiding the consumption of antibiotics and effectively preventing poultry bacterial diseases is a technical problem to be solved by the person skilled in the art.
Disclosure of Invention
In order to solve the technical problems, the invention provides a pharmaceutical composition for preventing and treating bacterial diseases of poultry and a preparation method thereof.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a pharmaceutical composition for preventing and treating bacterial diseases of poultry comprises the following raw materials in parts by weight: 10-25 parts of pulsatilla chinensis, 10-30 parts of scutellaria baicalensis, 15-30 parts of honeysuckle, 3-5 parts of houttuynia cordata, 7-11 parts of phellodendron amurense, 5-9 parts of coptis chinensis, 5-9 parts of radix isatidis, 2-5 parts of fructus forsythiae, 3-5 parts of dandelion and 1-2 parts of liquorice.
Preferably, the material comprises the following raw materials in parts by weight: 15-20 parts of pulsatilla chinensis, 15-20 parts of scutellaria baicalensis, 17-18 parts of honeysuckle, 3-4 parts of houttuynia cordata, 10-11 parts of phellodendron amurense, 6-8 parts of coptis chinensis, 5-7 parts of radix isatidis, 4-5 parts of fructus forsythiae, 4-5 parts of dandelion and 1 part of liquorice.
Preferably, the material comprises the following raw materials in parts by weight: 18 parts of pulsatilla chinensis, 19 parts of scutellaria baicalensis, 17 parts of honeysuckle, 4 parts of houttuynia cordata, 10 parts of phellodendron, 6 parts of coptis chinensis, 6 parts of radix isatidis, 5 parts of fructus forsythiae, 4 parts of dandelion and 1 part of liquorice.
The beneficial effects are that: the invention takes the pulsatilla root, the baikal skullcap root and the honeysuckle as monarch drugs, has the efficacy of clearing heat and detoxicating for poultry, and can effectively prevent and treat the escherichia coli and salmonella infection of the poultry under the combined action of the pulsatilla root, the baikal skullcap root and the honeysuckle. The compatibility of the radix scutellariae, the cortex phellodendri and the coptis chinensis can effectively prevent and treat the damage of escherichia coli to the intestinal tracts of poultry, the honeysuckle, the fructus forsythiae and the dandelion have good anti-inflammation and antipyretic effects, the synergistic effect of the three can effectively relieve symptoms such as inflammation and the like caused in the bacterial infection process of the poultry, the pulsatilla chinensis and the cordate houttuynia can clear heat and promote urination, and the synergistic effect of the three and other raw materials can effectively prevent and treat the bacterial infection of the poultry caused by salmonella. Finally, the liquorice which is a drug for enabling the liquorice to play a role in harmonizing various drugs, so that the drug property is milder.
A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following steps:
(1) Mixing the raw materials, decocting, filtering, and collecting filtrate and residue;
(2) Crushing the filter residues, mixing the crushed filter residues with a microbial agent for fermentation, and then performing high-temperature sterilization treatment to obtain a fermentation product;
(3) Concentrating the filtrate, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating bacterial diseases of poultry.
Preferably, the decoction in the step (1) is carried out for 0.5-1.5 hours after the raw materials are mixed with water with triple mass.
Preferably, in the step (2), the crushing is performed until the particle size is smaller than 3mm.
Preferably, the ratio of the filter residue to the microbial agent in the step (2) is 1:0.01-0.05;
the microbial agent comprises one or more of saccharomycetes, aspergillus niger, lactobacillus and bacillus subtilis.
Preferably, the fermentation temperature in the step (2) is 35-45 ℃ and the time is 5-8h;
the high temperature sterilization temperature is 90-100deg.C, and the time is 1-3min.
Preferably, the concentration in step (3) is 0.3-0.5 times of the original volume
The beneficial effects are that: the invention firstly utilizes the decoction method to carry out water extraction on the effective medicinal components in the medicinal composition, then carries out fermentation on filter residues to further release the medicinal components in the medicinal composition, and can be used as a part of feed supplement after the Chinese medicinal components are fermented into small molecular substances so as to realize the complete utilization of raw materials.
Compared with the prior art, the invention has the following advantages and technical effects:
according to the invention, the traditional Chinese medicine materials are used as raw materials, wherein the raw materials are in a synergistic effect relationship of monarch, minister, assistant and guide, so that the product can effectively prevent and treat intestinal diseases caused by salmonella and escherichia coli of poultry, the disease resistance of the poultry is improved, and medicines such as antibiotics are not required to be added in the invention, so that the drug resistance of the poultry caused by excessive use of the antibiotics is avoided, and meanwhile, the edible safety of human beings to the poultry is ensured. In addition, the invention can further improve the utilization rate of the pharmaceutical composition by fermenting the filter residues after decoction.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In order that the above-recited objects, features and advantages of the present invention will become more apparent, a more particular description of the invention will be rendered by reference to specific embodiments thereof.
The invention provides a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following raw materials in parts by weight: 10-30 parts of radix scutellariae, 15-30 parts of honeysuckle, 10-25 parts of pulsatilla chinensis, 3-5 parts of houttuynia cordata, 7-11 parts of phellodendron, 5-9 parts of coptis chinensis, 5-9 parts of radix isatidis, 2-5 parts of fructus forsythiae, 3-5 parts of dandelion and 1-2 parts of liquorice.
In some preferred embodiments, the raw material components are specifically: 15-20 parts of pulsatilla chinensis, 15-20 parts of scutellaria baicalensis, 17-18 parts of honeysuckle, 3-4 parts of houttuynia cordata, 10-11 parts of phellodendron amurense, 6-8 parts of coptis chinensis, 5-7 parts of radix isatidis, 4-5 parts of fructus forsythiae, 4-5 parts of dandelion and 1 part of liquorice.
Typical but non-limiting choices include the following raw materials in parts by weight: 18 parts of pulsatilla chinensis, 19 parts of scutellaria baicalensis, 17 parts of honeysuckle, 4 parts of houttuynia cordata, 10 parts of phellodendron, 6 parts of coptis chinensis, 6 parts of radix isatidis, 5 parts of fructus forsythiae, 4 parts of dandelion and 1 part of liquorice.
The pulsatilla root has the effects of killing and inhibiting bacteria, resisting oxidation and resisting inflammation, and can be used for treating heat toxin bloody dysentery, wen Nve cold and heat, epistaxis and blood hemorrhoids.
Jin Yin Hua is sweet and cold in nature. Enter lung and stomach meridians. Clearing away heat and toxic materials, diminishing inflammation and relieving swelling. Is mainly used for treating exogenous wind-heat or warm disease fever, heatstroke, toxic heat blood dysentery, carbuncle, furuncle, pharyngitis and various infectious diseases.
Bai Huang is bitter in flavor and cold in nature, purging excessive fire, removing dampness-heat, stopping bleeding and preventing abortion. For polydipsia due to strong heat, cough due to lung heat, diarrhea due to damp-heat, jaundice, stranguria due to heat, vomiting, epistaxis, metrorrhagia, conjunctival congestion, fetal irritability, carbuncle, swelling and furuncle.
Yu xing Cao is pungent in flavor, slightly warm in nature, clearing heat and removing toxicity, inducing diuresis to alleviate edema. Can be used for treating pneumonia, lung abscess, dysentery, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, rectocele, eczema, tinea, and scabies.
Huang Bai is bitter in flavor and cold in nature. Kidney and bladder meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore.
Coptis root, rhizoma Coptidis, with the effects of clearing heat and drying dampness, purging pathogenic fire and removing toxin. Can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, high fever unconsciousness, excessive heart fire, vexation, insomnia, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, and furuncle; it is used externally to treat eczema, wet sore and suppurative ear canal. Jiu Huang Lian is good at clearing heat from upper energizer. Can be used for treating conjunctival congestion and aphtha. Rhizoma coptidis can clear stomach, harmonize stomach and arrest vomiting. It is used for treating cold and heat accumulation, damp-heat retention, distention and fullness, and emesis. Yuhuanglian has the functions of soothing liver, regulating stomach and stopping vomiting. Can be used for treating incoordination between liver and stomach, emesis, and acid regurgitation.
Fructus forsythiae, bitter and cool. Enter heart, liver and gallbladder meridians. Clearing heat, detoxicating, resolving hard mass and detumescence. For warm heat, erysipelas, macula, carbuncle, ulcer, swelling and toxicity, scrofula and urine stranguria.
Dandelion, bitter, sweet and cold. Enter the liver and stomach meridians. Clearing away heat and toxic materials, promoting urination and resolving hard mass. Can be used for treating acute mastitis, lymphadenitis, scrofula, furuncle, conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
Glycyrrhrizae radix and its rhizome are used as medicine, and the main ingredients are triterpenes and flavonoids, and also contain alkaloids, polysaccharide, coumarin, amino acid, zn, ca, sr, ni, mn, fe, cu, cr, etc. Glycyrrhrizae radix has effects of invigorating spleen and replenishing qi, moistening lung and relieving cough, clearing heat and detoxicating, and harmonizing various medicines, and can be used for treating laryngopharynx swelling and pain, spleen and stomach deficiency cold, peptic ulcer, poisoning, etc.
The invention takes the pulsatilla root, the baikal skullcap root and the honeysuckle as monarch drugs, has the efficacy of clearing heat and detoxicating for poultry, and can effectively prevent and treat the escherichia coli and salmonella infection of the poultry under the combined action of the pulsatilla root, the baikal skullcap root and the honeysuckle. The compatibility of the radix scutellariae, the cortex phellodendri and the coptis chinensis can effectively prevent and treat the damage of escherichia coli to the intestinal tracts of poultry, the honeysuckle, the fructus forsythiae and the dandelion have good anti-inflammation and antipyretic effects, the synergistic effect of the three can effectively relieve symptoms such as inflammation and the like caused in the bacterial infection process of the poultry, the pulsatilla chinensis and the cordate houttuynia can clear heat and promote urination, and the synergistic effect of the three and other raw materials can effectively prevent and treat the bacterial infection of the poultry caused by salmonella. Finally, the liquorice which is a drug for enabling the liquorice to play a role in harmonizing various drugs, so that the drug property is milder.
In addition, the invention also provides a preparation method of the pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following steps:
(1) Mixing the raw materials, decocting, filtering, and collecting filtrate and residue;
(2) Crushing the filter residues, mixing the crushed filter residues with a microbial agent for fermentation, and then performing high-temperature sterilization treatment to obtain a fermentation product;
(3) Concentrating the filtrate, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating bacterial diseases of poultry.
Further, the decoction in the step (1) is to mix the raw materials with water with triple mass and then decoct for 0.5-1.5h.
Further, in the step (2), the crushing is performed until the particle size is smaller than 3mm.
Further, the ratio of the filter residue to the microbial agent in the step (2) is 1:0.01-0.05.
Further, the microbial agent comprises one or more of saccharomycetes, aspergillus niger, lactobacillus and bacillus subtilis.
Further, the fermentation temperature in the step (2) is 35-45 ℃ and the fermentation time is 5-8h;
the high temperature sterilization temperature is 90-100deg.C, and the time is 1-3min.
Further, the concentration in the step (3) is 0.3-0.5 times of the original volume.
The technical scheme of the invention is further described in detail through specific examples.
Example 1
A pharmaceutical composition for preventing and treating bacterial diseases of poultry comprises the following raw materials in parts by weight: 18 parts of pulsatilla chinensis, 19 parts of scutellaria baicalensis, 17 parts of honeysuckle, 4 parts of houttuynia cordata, 10 parts of phellodendron, 6 parts of coptis chinensis, 6 parts of radix isatidis, 5 parts of fructus forsythiae, 4 parts of dandelion and 1 part of liquorice.
A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following steps:
(1) Mixing the raw materials, adding water with triple mass, decocting for 1h, filtering, and collecting filtrate and filter residue;
(2) Crushing filter residues, wherein the particle size is smaller than 3mm, mixing the crushed filter residues with a microbial agent according to the mass ratio of 1:0.03, fermenting for 7 hours at 40 ℃, and then treating for 1min at a high temperature of 95 ℃ to obtain a fermentation product; wherein the microbial agent is a mixed microbial agent of saccharomycetes and aspergillus niger with the mass ratio of 1:1;
(3) Concentrating the filtrate to 0.4 times of the original volume, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating poultry bacterial diseases.
Example 2
A pharmaceutical composition for preventing and treating bacterial diseases of poultry comprises the following raw materials in parts by weight: 15 parts of pulsatilla chinensis, 20 parts of scutellaria baicalensis, 17 parts of honeysuckle, 4 parts of houttuynia cordata, 10 parts of phellodendron, 6 parts of coptis chinensis, 7 parts of radix isatidis, 5 parts of fructus forsythiae, 5 parts of dandelion and 1 part of liquorice.
A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following steps:
(1) Mixing the raw materials, adding water with triple mass, decocting for 0.5h, filtering, and collecting filtrate and filter residue;
(2) Crushing filter residues, mixing the crushed filter residues with the particle size of less than 3mm and microbial agents in a mass ratio of 1:0.05, fermenting for 8 hours at 35 ℃, and then treating for 3 minutes at a high temperature of 100 ℃ to obtain a fermentation product; wherein the microbial agent is a mixed microbial agent of aspergillus niger and lactobacillus in a mass ratio of 1:1;
(3) Concentrating the filtrate to 0.3 times of the original volume, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating poultry bacterial diseases.
Example 3
A pharmaceutical composition for preventing and treating bacterial diseases of poultry comprises the following raw materials in parts by weight: 30 parts of radix scutellariae, 30 parts of honeysuckle, 13 parts of pulsatilla chinensis, 3 parts of houttuynia cordata, 7 parts of phellodendron, 9 parts of coptis chinensis, 9 parts of radix isatidis, 2 parts of fructus forsythiae, 5 parts of dandelion and 2 parts of liquorice.
A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which comprises the following steps:
(1) Mixing the raw materials, adding water with triple mass, decocting for 1.5h, filtering, and collecting filtrate and filter residue;
(2) Crushing filter residues, mixing the crushed filter residues with the particle size of less than 3mm and a microbial agent in a mass ratio of 1:0.01, fermenting for 5 hours at 45 ℃, and then treating for 2 minutes at a high temperature of 90 ℃ to obtain a fermentation product; the microbial agent is a mixed microbial agent of saccharomycetes and bacillus subtilis in a mass ratio of 1:1;
(3) Concentrating the filtrate to 0.5 times of the original volume, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating poultry bacterial diseases.
Comparative example 1
A pharmaceutical composition for preventing and treating bacterial diseases of poultry, which is different from example 1 in that: the pulsatilla root is excluded.
Comparative example 2
A pharmaceutical composition for preventing and treating bacterial diseases of poultry, which is different from example 1 in that: no honeysuckle is included.
Comparative example 3
A pharmaceutical composition for preventing and treating bacterial diseases of poultry, which is different from example 1 in that: excluding Scutellariae radix and cortex Phellodendri.
Comparative example 4
A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry, which is different from example 1 in that: the fermentation process is not included in step (2).
The technical effects are as follows:
the average of 7 groups of layers were cultivated in the henhouse, and 100 layers of each group were fed with the pharmaceutical compositions obtained in examples 1 to 3 and comparative examples 1 to 4, respectively, in the feeding process, wherein the amount of the feed was 0.5 to 1% by mass of the feed. The number of layers in different henhouses infected with E.coli or Salmonella-induced bacterial enteritis was observed and recorded.
The number of layers and the prevalence rate after 60 days of cultivation are shown in table 1:
TABLE 1
As can be seen from the above table, the pharmaceutical composition obtained by the invention can effectively prevent and treat intestinal diseases caused by salmonella and escherichia coli of the laying hen, in addition, in the diseased chicken group in the comparative example 1, the prevalence rate of salmonella infection is higher, and in the diseased chicken group in the comparative example 3, the prevalence rate of escherichia coli infection is higher, and is more than 75% of the diseased chicken group, therefore, the monarch drug pulsatilla and other pharmaceutical components in the invention cooperate to effectively prevent and treat salmonella infection, and the baikal skullcap root and the phellodendron bark cooperate with other raw materials to more effectively prevent and treat escherichia coli infection. In addition, since the fermentation treatment of the residue was not performed in comparative example 4, the components in the residue were not effectively utilized, and thus the drug effect was reduced.
The foregoing is merely a preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions easily conceivable by those skilled in the art within the technical scope of the present application should be covered in the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (9)
1. The medicine composition for preventing and treating the bacterial diseases of the poultry is characterized by comprising the following raw materials in parts by weight: 10-25 parts of pulsatilla chinensis, 10-30 parts of scutellaria baicalensis, 15-30 parts of honeysuckle, 3-5 parts of houttuynia cordata, 7-11 parts of phellodendron amurense, 5-9 parts of coptis chinensis, 5-9 parts of radix isatidis, 2-5 parts of fructus forsythiae, 3-5 parts of dandelion and 1-2 parts of liquorice.
2. The pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15-20 parts of pulsatilla chinensis, 15-20 parts of scutellaria baicalensis, 17-18 parts of honeysuckle, 3-4 parts of houttuynia cordata, 10-11 parts of phellodendron amurense, 6-8 parts of coptis chinensis, 5-7 parts of radix isatidis, 4-5 parts of fructus forsythiae, 4-5 parts of dandelion and 1 part of liquorice.
3. The pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of pulsatilla chinensis, 19 parts of scutellaria baicalensis, 17 parts of honeysuckle, 4 parts of houttuynia cordata, 10 parts of phellodendron, 6 parts of coptis chinensis, 6 parts of radix isatidis, 5 parts of fructus forsythiae, 4 parts of dandelion and 1 part of liquorice.
4. A method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry according to any one of claims 1 to 3, comprising the steps of:
(1) Mixing the raw materials, decocting, filtering, and collecting filtrate and residue;
(2) Crushing the filter residues, mixing the crushed filter residues with a microbial agent for fermentation, and then performing high-temperature sterilization treatment to obtain a fermentation product;
(3) Concentrating the filtrate, and mixing with the fermentation product to obtain the pharmaceutical composition for preventing and treating bacterial diseases of poultry.
5. The method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 4, wherein the decoction in the step (1) is 0.5-1.5 hours after mixing the raw materials with water of triple mass.
6. The method of claim 4, wherein the pulverizing in the step (2) is performed to a particle size of less than 3mm.
7. The method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 4, wherein the ratio of the filter residue to the microbial agent in the step (2) is 1:0.01-0.05;
the microbial agent comprises one or more of saccharomycetes, aspergillus niger, lactobacillus and bacillus subtilis.
8. The method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 4, wherein the fermentation temperature in the step (2) is 35-45 ℃ for 5-8 hours;
the high temperature sterilization temperature is 90-100deg.C, and the time is 1-3min.
9. The method for preparing a pharmaceutical composition for preventing and treating bacterial diseases of poultry according to claim 4, wherein the concentration in the step (3) is 0.3-0.5 times of the original volume.
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