CN116211961B - Composition for preventing and treating rumen acidosis of ruminant animals, oral preparation containing composition, preparation method and using method - Google Patents
Composition for preventing and treating rumen acidosis of ruminant animals, oral preparation containing composition, preparation method and using method Download PDFInfo
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- CN116211961B CN116211961B CN202310008872.1A CN202310008872A CN116211961B CN 116211961 B CN116211961 B CN 116211961B CN 202310008872 A CN202310008872 A CN 202310008872A CN 116211961 B CN116211961 B CN 116211961B
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Abstract
The invention belongs to the technical field of livestock feed additives, and particularly discloses a composition for preventing and treating rumen acidosis of ruminants, an oral preparation containing the composition, a preparation method and a use method, wherein the composition comprises the following components: red jujube powder, chinese honeylocust fruit, arborvitae tops, bletilla tuber, magnolia bark, radish seed, chinaroot greenbrier rhizome, bitter orange, dried orange peel, clove, wrinkled gianthyssop herb, white peony root, white atractylodes rhizome, licorice root, active dry yeast, yeast extract and yeast cell wall. The composition defined by the invention has the advantages that the interaction among various components can regulate acidogenic flora in the rumen of ruminant, promote salivary secretion and rumination, neutralize gastric acid, protect gastrointestinal mucosa, balance rumen, improve immunity and prevent gastric acidosis of ruminant tumor, and the oral preparation prepared according to the composition has no resistance and no pollution, is safe and effective, can be directly added into daily ration, has good palatability, and can improve the health of rumen and livestock after long-term use; in addition, the preparation method is simple, the cost is low, and the preparation method has important economic and social benefits.
Description
Technical Field
The invention belongs to the technical field of livestock feed additives, and particularly relates to a composition for preventing and treating rumen acidosis of ruminants, an oral preparation containing the composition, a preparation method and a use method.
Background
Rumen acidosis is caused by excessive ingestion of grains or rich in carbohydrate in a short time, so that rumen microbiota is changed, the number of gram positive bacteria (such as streptococcus bovis) is increased sharply, and the bacteria decompose to generate a large amount of lactic acid, so that the pH of the content is reduced, ciliates, cellulolytic bacteria and lactic acid utilizing bacteria die in a large amount, and the generated lactic acid exceeds the metabolic function of liver to cause metabolic acidosis;
in the breeding mode of the house, coarse fodder is in shortage or poor in quality, and due to production requirements, a high-precision fodder breeding mode is often adopted in the milk producing period of the dairy cows and the sheep fattening period, and the large-scale use of the concentrate can cause the severe decrease of the rumen pH, and excessive concentrate can not well promote ruminant, so that saliva secretion is insufficient, excessive gastric acid can not be neutralized, and more acute and subclinical rumen acidosis occurs. The prevention and the treatment are mainly to add sodium bicarbonate and magnesium oxide or to drench antibiotics to inhibit pathogenic bacteria; however, sodium bicarbonate enters rumen and can quickly release and neutralize acid, so that pH is quickly increased, fluctuation is large, gastrointestinal stress is large, appetite is easily reduced, nerves, urinary system and digestive system disorder are easily caused after long-term use, and alkali poisoning is easily caused by excessive use; antibiotics and the like are easy to generate drug resistance and residue, and have great harm to the environment, livestock products and human safety; at present, no alternative product which is stable and efficient, can be used for a long time, is natural, has no resistance, has no side effect and has no environmental stress exists;
therefore, it is an urgent need to solve the problems of the art to provide a composition and an oral preparation for preventing and treating rumen acidosis of ruminants, which have simple preparation method and can be directly added into daily ration, and can be taken for a long time.
Disclosure of Invention
In view of the above, the present invention aims to provide a composition for preventing and treating rumen acidosis of ruminant animals, which can regulate acidogenic bacteria, promote salivary secretion and rumination, neutralize gastric acid, protect gastrointestinal mucosa, balance rumen, and improve immunity, an oral preparation containing the same, a preparation method and a use method thereof. The prepared preparation product has no resistance and pollution, is safe and effective, can be used for a long time to improve the health of rumen and livestock, can be directly added into daily ration for feeding livestock and poultry, and has convenient use and good palatability. The preparation method is simple to operate and low in processing cost.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a composition for preventing and treating rumen acidosis of ruminants comprises the following raw materials in parts by weight: 30-60 parts of red date powder, 10-30 parts of Chinese honeylocust fruit, 5-15 parts of cacumen biotae, 3-10 parts of rhizoma bletillae, 10-20 parts of magnolia officinalis, 10-20 parts of radish seed, 5-10 parts of chinaroot greenbrier rhizome, 5-10 parts of fructus aurantii, 5-15 parts of dried orange peel, 5-10 parts of clove, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of white paeony root, 10-20 parts of bighead atractylodes rhizome, 5-15 parts of liquorice, 10-30 parts of active dry yeast, 5-10 parts of yeast extract and 5-10 parts of yeast cell wall.
The invention limits the functions of various components, wherein the yeast and the extracts and cell walls thereof can inhibit pathogenic bacteria, promote the growth of beneficial bacteria and improve the palatability of the traditional Chinese medicine; the natural plant contains various traditional Chinese medicine bioactive components, can regulate acidogenic bacteria, inhibit pathogenic bacteria, reduce lactic acid and toxin generation, regulate gastrointestinal bacteria balance, protect gastrointestinal mucosa and microecology, promote salivary secretion and rumination, neutralize gastric acid, enhance immunity and digestion capability, and can be used for balancing rumen and preventing and treating rumen acidosis. The specific compounding relation is as follows: fructus Jujubae is used as main medicine for invigorating spleen and stomach; magnolia officinalis, radish seed, liudamu, fructus Aurantii, dampness resolving, qi moving, stagnation removing, herba Pogostemonis, dampness resolving, stomach harmonizing, flos Caryophylli, adverse qi lowering, stomach warming, radix Paeoniae alba, pain relieving, and rhizoma Atractylodis Macrocephalae, qi invigorating, and dampness eliminating; chinese honeylocust fruit has effects of inducing resuscitation, diminishing inflammation, relieving constipation, and folium Platycladi for dispelling pathogenic wind, removing toxic substance, and rhizoma Bletillae for astringing, detumescence and promoting granulation; licorice root, radix Glycyrrhizae Praeparata regulates the drugs. Wherein, the efficacy of each component in the composition of the invention is:
fructus Jujubae is a mature fruit of Rhamnaceae plant fructus Jujubae ziziziphus jujumill. Warm nature and sweet taste. Enter spleen and stomach meridians. Tonify middle energizer and qi, invigorate spleen and stomach, nourish blood and tranquilize mind. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, anorexia, loose stool, internal injury of liver and spleen, etc. Contains bioactive substances such as polysaccharides, phenols, flavonoids, saponins, triterpene acids, alkaloids, dietary fiber, etc., and has antioxidant, antiinflammatory, intestinal flora regulating, immunity regulating, liver injury reducing, and fatigue relieving effects.
Fructus Gleditsiae Abnormalis is dry sterile fruit of Gleditsiae Abnormalis of Leguminosae, and is also called fructus Gleditsiae Abnormalis, herba Cyrtymeniae, fructus Gleditsiae Abnormalis, herba Pogostemonis, and radix Rhinocerotis. Warm nature and pungent taste. Enter lung meridian and large intestine meridian. Inducing resuscitation, eliminating phlegm, relieving inflammation, resolving hard mass, relieving swelling, moistening dryness, and relaxing bowels.Is used for dispelling pathogenic wind and phlegm, removing dampness and toxic materials, and killing parasites. Contains saponins, tannins, sterols, etc., has effects in eliminating phlegm, relieving inflammation, inhibiting pathogenic bacteria and dermatophytes in gram negative intestine, and treating apoplexyOblique, headache, cough, asthma, diarrhea, dysentery, vomiting, carbuncle, swelling, sore, tinea, scabies, etc.
The cacumen Platycladi is branch tip and leaf of Platycladus orientalis of Platycladus of Cupressaceae. Slightly cold in nature, bitter and astringent in taste, and enters lung, liver and spleen meridians. Has effects of cooling blood, stopping bleeding, eliminating phlegm, relieving cough, dispelling pathogenic wind, and removing toxic substances, and can be used for treating hematemesis, hematuria, bloody dysentery, and intestinal wind. Mainly contains volatile oil, contains alpha-hinokitiol, foeniculi Fructs ketone, etc., and has effects in inhibiting Staphylococcus aureus, card tacoccus, bacillus dysenteriae, and Streptococcus B, relieving cough, eliminating phlegm, relieving asthma, and lowering blood pressure.
Rhizoma bletilla is rhizome of Bletillae rhizoma of Bletillae of Orchidaceae. Slightly cold in nature, bitter, sweet and astringent in taste. It enters lung, liver and stomach meridians. Astringing to stop bleeding, detumescence and promoting granulation. Rhizoma bletilla is mainly composed of mucilage, volatile oil, starch, etc., and has effects of relieving gastric acid injury to gastric mucosa and protecting gastric mucosa.
Magnolia bark is bark, root bark and branch bark of Magnolia genus of Magnoliaceae family. Warm nature and pungent taste. Enter spleen meridian, stomach meridian and large intestine meridian. Has effects of eliminating dampness, relieving stagnation, promoting qi circulation, relieving asthma, resolving food stagnation, eliminating phlegm, dispelling pathogenic wind, and relieving pain, and can be used for treating food stagnation, abdominal distention, constipation, damp obstruction of middle energizer, gastric fullness, vomiting, diarrhea, chest distress, cough, asthma, etc. Mainly contains volatile oil, magnolol and other active ingredients, and has stronger antibacterial effect on a plurality of pathogenic bacteria such as staphylococcus, streptococcus, pasteurella and the like.
Radish seed is the mature seed of radish plant of the genus radish of the family cruciferae. Neutral nature, pungent and sweet in flavor, enters the three meridians of lung, spleen and stomach. It has effects in resolving food stagnation, and reducing qi and phlegm, and can be used for treating food stagnation, abdominal distention and pain, constipation, diarrhea, dysentery, and phlegm stagnation. Contains antibacterial active substances such as Raphani semen, and can inhibit growth of Staphylococcus, escherichia coli, streptococcus, pneumococcus, escherichia coli, etc.
The Liuzhu is fruit of Liuzhu of Caprifoliaceae. Neutral nature, slightly bitter and astringent taste, and enters liver, kidney and heart meridians. Dispelling pathogenic wind, removing dampness, relieving swelling and pain, and treating rheumatic arthralgia and myalgia, carbuncle, toxic materials, and swelling.
Fructus Aurantii is dried mature fruit of Citrus aurantium or Citrus sinensis of Rutaceae. Warm nature, bitter, pungent and sour taste, and enters spleen and stomach meridians. Broken qi, promoting phlegm and resolving food stagnation, and can be used for treating abdominal distention, dyspepsia, phlegm retention, dyspnea, and prolapse. Mainly contains volatile oil and flavonoid glycoside, and can doubly regulate gastrointestinal smooth muscle.
Pericarpium Citri Tangerinae is mature pericarp of Citrus reticulata Blanco of Citrus of Rutaceae and its cultivar. Warm nature, bitter and pungent taste. Enter spleen meridian, stomach meridian and lung meridian. Has effects of regulating qi-flowing, regulating middle warmer, lowering adverse qi, relieving vomit, eliminating dampness, and eliminating phlegm, and can be used for treating chest distress, abdominal distention and pain, anorexia, emesis, cough with excessive phlegm, and acute mastitis. Mainly contains volatile oil, hesperidin, flavonoids, etc., has antiinflammatory, antiulcer, and cholagogic effects, and can inhibit growth of staphylococcus and haemophilus haemolyticus.
Flos Caryophylli is bud of flos Caryophylli of Syringa of Myrtaceae. Warm nature and pungent taste. Enter stomach meridian and kidney meridian. Has effects in warming middle warmer, lowering adverse qi, warming stomach, and warming kidney, and can be used for treating aversion to cold, singultus, emesis, regurgitation, dysentery, epigastralgia, hernia, etc. The essential oil, namely clove oil, has the effects of invigorating stomach, relieving distension, promoting exhaustion, relieving nausea and vomiting, relieving abdominal distension, and inhibiting bacteria and pathogenic fungi.
Herba Agastaches is aerial part of plant of Agastache of Labiatae, and has mild nature and pungent taste, and enters spleen, stomach and lung channels. Has effects of eliminating turbid pathogen, regulating middle energizer, relieving vomit, and relieving summer-heat. Can be used for treating damp obstruction in middle energizer, gastric fullness and emesis, summer-heat and dampness exterior syndrome, damp warm beginning, fever and listlessness, chest distress and discomfort, cold dampness and summer-heat obstruction, abdominal pain and vomiting and diarrhea, and nasosinusitis headache. The main active ingredients are various aromatic volatile oils, which can inhibit the growth of staphylococcus aureus, bacillus subtilis and common pathogenic fungi, and can also prevent corrosion, promote digestion, relieve spasm and ease pain.
White peony root is the root of the perennial herb Paeonia lactiflora of Ranunculaceae. Cool in nature and bitter in taste, enter liver and spleen meridians. Has effects of nourishing blood, softening liver, relieving pain, astringing yin, and promoting perspiration, and can be used for treating diarrhea, abdominal pain, spontaneous perspiration, night sweat, chest pain, abdomen pain, hypochondrium pain, menoxenia, etc. Mainly contains paeoniflorin, beta-sitosterol and the like, has inhibiting effect on staphylococcus, hemolytic streptococcus, pneumococcus, escherichia coli and the like, has relaxing effect on gastrointestinal smooth muscle to different degrees, and can slow down contracture and relieve pain.
Atractylodis rhizoma is dry rhizome of Atractylodis rhizoma of Compositae. Warm nature, sweet and bitter taste, and enters spleen and stomach meridians. Invigorating spleen, replenishing qi, eliminating dampness, promoting diuresis, consolidating superficial resistance, and stopping sweat, and can be used for treating spleen and stomach qi weakness, anorexia, listlessness, hypoqi, deficiency distention, diarrhea, etc. The essential oil mainly contains vitamin A and volatile oil, and the essential oil mainly contains atractylol, atractylone and the like, has the effects of reducing blood sugar, protecting liver, promoting urination and regulating immunity, and has the inhibiting effect on typhoid bacillus, escherichia coli, pseudomonas aeruginosa and the like.
Glycyrrhrizae radix is dry root and rhizome of Glycyrrhiza uralensis Fisch.L.of Leguminosae, glycyrrhiza uralensis Fisch.L.or Glycyrrhiza glabra Fisch. Neutral in nature, sweet in flavor, enters twelve meridians. Tonify middle-jiao, replenish qi, clear away heat and toxic materials, moisten lung, relieve cough, harmonize various drugs, and mainly treat carbuncle, sore, cough, pharyngalgia, weakness of spleen and stomach, qi deficiency, blood deficiency, common cold, stomach pain, etc. Mainly contains active ingredients such as glycyrrhizic acid, glycyrrhiza polysaccharide and the like, and has stronger effects of detoxification, anti-inflammatory and immunity regulation.
Preferably, the composition comprises the following raw materials in parts by weight: 60 parts of red date powder, 20 parts of Chinese honeylocust fruit, 10 parts of biota orientalis, 6 parts of bletilla, 15 parts of magnolia officinalis, 15 parts of radish seed, 5 parts of six-way wood, 8 parts of fructus aurantii, 10 parts of dried orange peel, 8 parts of clove, 8 parts of wrinkled gianthyssop herb, 6 parts of white peony root, 15 parts of bighead atractylodes rhizome, 5 parts of liquorice, 20 parts of active dry yeast, 10 parts of yeast extract and 10 parts of yeast cell wall.
An oral formulation comprising the composition.
Preferably, the oral preparation is a granule.
The preparation method of the granule comprises the following steps:
(1) Firstly, respectively drying and crushing red date powder, chinese honeylocust fruit, biota orientalis, bletilla tuber, magnolia bark, radish seed, chinaroot greenbrier rhizome, bitter orange, dried orange peel, clove, wrinkled gianthyssop herb, white peony root, largehead atractylodes rhizome and liquorice, wherein the drying temperature is 50-60 ℃, the moisture content is not higher than 25 percent after drying, and mixing according to the formula dosage;
(2) Then adding active dry yeast, yeast extract and yeast cell walls into the mixture, uniformly mixing, and carrying out low temperature Leng Zhili;
(3) Finally, molasses spray coating is carried out.
Preferably, the mixture in the step (1) is sieved by a 40-50 mesh sieve.
Preferably, the low temperature in step (2) is 18-25 ℃.
Preferably, the particle size of the granules obtained in the step (2) is 3.0-3.5mm, and the moisture content is less than or equal to 14%.
The use method of the oral preparation comprises the steps of 4-8%o of the weight ratio of the oral preparation to daily ration.
Compared with the prior art, the invention discloses a composition for preventing and treating rumen acidosis of ruminants, a preparation method and a use method. The method has the following technical effects:
1. the interaction among the components in the oral preparation prepared by the composition can regulate acidogenic bacteria, promote salivary secretion and rumination, neutralize gastric acid, protect gastrointestinal mucosa, balance rumen and improve immunity, so that rumen acidosis of ruminants can be well prevented and treated;
2. the oral preparation prepared by the invention has no resistance and pollution, is safe and effective, can be directly added into daily ration for feeding livestock and poultry, and has convenient use and good palatability;
3. the preparation method provided by the invention is simple to operate, low in processing cost, convenient to apply, energy-saving and environment-friendly, and has important economic and social benefits.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The experimental methods used in the following application examples are all conventional methods unless otherwise specified; the reagents, materials, and the like used, unless otherwise indicated, are all commercially available. For example, active dry yeast, yeast extract, and yeast cell walls were all purchased from Angel Yeast Co. Specifically, active dry yeast: special for ruminant, the viable count is more than or equal to 200 hundred million/g, and yeast extract: 99% of yeast cell wall: the mannans are more than or equal to 20 percent, and the beta-glucan is 20 to 35 percent.
Example 1
A composition for preventing and treating rumen acidosis of ruminants comprises the following raw materials in parts by weight: 60 parts of red date powder, 20 parts of Chinese honeylocust fruit, 10 parts of biota orientalis, 6 parts of bletilla, 15 parts of magnolia officinalis, 15 parts of radish seed, 5 parts of six-way wood, 8 parts of fructus aurantii, 10 parts of dried orange peel, 8 parts of clove, 8 parts of wrinkled gianthyssop herb, 6 parts of white peony root, 15 parts of bighead atractylodes rhizome, 5 parts of liquorice, 20 parts of active dry yeast, 10 parts of yeast extract and 10 parts of yeast cell wall.
A preparation method of granules for preventing and treating rumen acidosis of ruminants comprises the following steps:
1. firstly, respectively drying and crushing red date powder, chinese honeylocust fruit, biota orientalis, bletilla tuber, magnolia bark, radish seed, six-way wood, bitter orange, dried orange peel, clove, wrinkled gianthyssop, white peony root, white atractylodes rhizome and liquorice, mixing according to the formula dosage, and sieving with a 40-50 mesh sieve;
2. then adding active dry yeast, yeast extract and yeast cell wall, mixing uniformly, granulating at 18-25deg.C with particle diameter of 3.0-3.5mm and water content less than or equal to 14%;
3. finally, molasses spray coating is carried out.
Example 2
A composition for preventing and treating rumen acidosis of ruminants, comprising the following raw materials: 30 parts of red date powder, 10 parts of Chinese honeylocust fruit, 5 parts of cacumen biotae, 3 parts of bletilla, 10 parts of magnolia officinalis, 10 parts of radish seed, 5 parts of six-way wood, 5 parts of fructus aurantii, 5 parts of dried orange peel, 5 parts of clove, 5 parts of wrinkled gianthyssop herb, 5 parts of white peony root, 10 parts of bighead atractylodes rhizome, 5 parts of liquorice, 10 parts of active dry yeast, 5 parts of yeast extract and 5 parts of yeast cell wall.
A preparation method of granule for preventing and treating ruminant rumen acidosis comprises the same steps as in example 1.
Example 3
A composition for preventing and treating rumen acidosis of ruminants, comprising the following raw materials: 60 parts of red date powder, 30 parts of Chinese honeylocust fruit, 15 parts of cacumen biotae, 10 parts of bletilla, 20 parts of magnolia officinalis, 20 parts of radish seed, 10 parts of six-way wood, 10 parts of fructus aurantii, 15 parts of dried orange peel, 10 parts of clove, 10 parts of wrinkled gianthyssop herb, 10 parts of white peony root, 20 parts of bighead atractylodes rhizome, 15 parts of liquorice, 30 parts of active dry yeast, 10 parts of yeast extract and 10 parts of yeast cell wall.
A preparation method of granule for preventing and treating ruminant rumen acidosis comprises the same steps as in example 1.
Effect verification
Effect example 1
The granules 1, 2 and 3 are prepared according to the examples 1-3, a fattening period beef cattle feeding test is carried out, 80 beef cattle with weight more than 300kg are selected for the test, the beef cattle feeding test is divided into four groups, namely 1 group, 2 group, 3 group and blank control group, conventional daily ration feeding is carried out, each group comprises 20 heads, each group comprises 1, 2 and 3 groups, 200g of the composition 1, 2 and 3 are respectively added into daily ration, the product is continuously added for 2 months, basic daily ration (hay free feeding, a fine feeding formula comprises corn, nomin 6530 concentrate and bran which are mixed according to a ratio of 65:30:5) and a feeding management mode are consistent, and rumen acidosis prevention test effect observation is carried out. The test results are shown in Table 1:
TABLE 1
From the test results, granules 1, 2 and 3 have better preventive effects on rumen acidosis, wherein the effects of the granules in test groups 1 and 3 are better, and the effects of the granules in example 1 are optimal in consideration of use cost and palatability.
Effect example 2:
a composition 1 was prepared as in example 1, and feeding experiments were performed on 120 mutton sheep of the same breed and weight of 30.+ -. 4.49kg, and the feed composition was divided into four groups, namely group A (high-concentrate ration), group B (high-concentrate ration+50 g/day granule 1), group C (high-concentrate ration+75 g/day granule 1), and group D (high-concentrate ration+100 g/day granule 1),
30 animals are in each group, the basic ration and the feeding management mode are consistent, the composition is continuously added for 1 three months, and the incidence of gastric acidosis of tumor is counted. The test results are shown in Table 2:
TABLE 2
The test results show that the granule 1 with high, medium and low doses has better prevention effect on rumen acidosis of mutton sheep, wherein the granule 1 with high, medium doses has better effect.
In this specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by a difference from other embodiments, and identical and similar parts between the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. The composition for preventing and treating ruminant rumen acidosis is characterized by comprising the following components in parts by weight: 30-60 parts of red date powder, 10-30 parts of Chinese honeylocust fruit, 5-15 parts of cacumen biotae, 3-10 parts of rhizoma bletillae, 10-20 parts of magnolia officinalis, 10-20 parts of radish seed, 5-10 parts of chinaroot greenbrier rhizome, 5-10 parts of fructus aurantii, 5-15 parts of dried orange peel, 5-10 parts of clove, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of white paeony root, 10-20 parts of bighead atractylodes rhizome, 5-15 parts of liquorice, 10-30 parts of active dry yeast, 5-10 parts of yeast extract and 5-10 parts of yeast cell wall.
2. The composition for preventing and treating rumen acidosis of ruminants according to claim 1, wherein the composition comprises the following components in parts by weight: 60 parts of red date powder, 20 parts of Chinese honeylocust fruit, 10 parts of biota orientalis, 6 parts of bletilla, 15 parts of magnolia officinalis, 15 parts of radish seed, 5 parts of six-way wood, 8 parts of fructus aurantii, 10 parts of dried orange peel, 8 parts of clove, 8 parts of wrinkled gianthyssop herb, 6 parts of white peony root, 15 parts of bighead atractylodes rhizome, 5 parts of liquorice, 20 parts of active dry yeast, 10 parts of yeast extract and 10 parts of yeast cell wall.
3. An oral formulation comprising the composition of any one of claims 1-2.
4. The oral formulation of claim 3, wherein the formulation is a granule.
5. The method of preparing a composition according to any one of claims 1-2 or an oral formulation according to claim 4, comprising the steps of:
(1) Respectively drying and crushing the red date powder, the Chinese honeylocust fruit, the biota orientalis, the bletilla tuber, the magnolia officinalis, the radish seed, the six-way wood, the bitter orange, the dried orange peel, the clove, the wrinkled gianthyssop herb, the white paeony root, the white atractylodes rhizome and the liquorice, wherein the drying temperature is 50-60 ℃, the moisture content is not higher than 25 percent after the drying, and mixing and sieving according to the parts by weight;
(2) Adding the active dry yeast, the yeast extract and the yeast cell wall in parts by weight into the sieved mixture, uniformly mixing, and carrying out low-temperature Leng Zhili;
(3) Finally, molasses spray coating is carried out.
6. The method of claim 5, wherein the mixing in step (1) is followed by sieving through a 40-50 mesh sieve.
7. The method according to claim 5, wherein the low temperature in step (2) is 18 to 25 ℃.
8. The process according to claim 5, wherein the particle size of the granules obtained in step (2) is 3.0-3.5mm and the moisture content is not more than 14%.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348801A (en) * | 2001-10-26 | 2002-05-15 | 陈新 | Veterinary medicine for preventing and treating animal's gastrointestinal tract diseases |
| CN105727143A (en) * | 2016-04-04 | 2016-07-06 | 黄平县东宏牧业专业合作社 | Traditional Chinese medicine composition for treating cow spleen-asthenic inappetence |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348801A (en) * | 2001-10-26 | 2002-05-15 | 陈新 | Veterinary medicine for preventing and treating animal's gastrointestinal tract diseases |
| CN105727143A (en) * | 2016-04-04 | 2016-07-06 | 黄平县东宏牧业专业合作社 | Traditional Chinese medicine composition for treating cow spleen-asthenic inappetence |
Non-Patent Citations (1)
| Title |
|---|
| 牛瘤胃病验方3则;卜丽芳;湖南畜牧兽医;-(第01期);34-35 * |
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