CN114681562B

CN114681562B - Traditional Chinese medicine prescription for treating infectious bronchitis and preparation method thereof

Info

Publication number: CN114681562B
Application number: CN202011645556.8A
Authority: CN
Inventors: 孙祥仓; 陈培强; 胡付立
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-28
Filing date: 2020-12-28
Publication date: 2023-08-18
Anticipated expiration: 2040-12-28
Also published as: CN114681562A

Abstract

A traditional Chinese medicine prescription for treating infectious bronchitis of chickens consists of the following raw materials in parts by weight: 25-30 parts of honeysuckle, 20-25 parts of radix scutellariae, 20-25 parts of fructus forsythiae, 25-28 parts of coptis chinensis, 25-30 parts of fructus gardeniae, 18-20 parts of radix astragali, 20-22 parts of bitter apricot seed, 26-28 parts of platycodon grandiflorum, 18-21 parts of fritillary bulb, 15-16 parts of radix codonopsis, 15-20 parts of liquorice and 15-20 parts of pulsatilla chinensis; 12-15 parts of phellodendron bark and 10-12 parts of houttuynia cordata. The traditional Chinese medicine for treating infectious bronchitis has the effects and characteristics of good heat-clearing and detoxicating, antivirus, lung diffusing and phlegm resolving, cough and asthma relieving, body resistance strengthening and constitution consolidating, nonspecific immunity improving, antibacterial and anti-inflammatory effects, no medicine residue, no toxic or side effect, low cost and difficult recurrence after healing.

Description

Traditional Chinese medicine prescription for treating infectious bronchitis and preparation method thereof

Technical Field

The application relates to a traditional Chinese medicine prescription for treating infectious bronchitis and a preparation method thereof.

Background

Due to the gradual expansion of the poultry raising scale, the single-span raising density is higher and higher, and the health of animals is seriously threatened by some poultry respiratory tract diseases. In recent years, avian infectious bronchitis has been in a epidemic outbreak in some farmers. Although vaccine prevention is the main method for preventing and treating the disease, the disease caused by immune failure and other immunosuppression is still layered endlessly, no special medicine is available in western medicine treatment at present, and the method mainly comprises the steps of feeding large-dose antibiotics to prevent secondary infection, reduce the disease rate and the death rate, and can not radically treat the disease although the method has a certain effect, so that huge losses are brought to vast farms. Because of the large dosage of antibiotics, the poultry organisms have high drug residues, the drug resistance of the antibiotics gradually appears, the threat of animal epidemic diseases gradually exceeds the update of new antibiotics, the treatment difficulty gradually increases, and even the step of drug-free treatment appears. In addition, people have super-strong drug resistance caused by eating poultry meat and poultry eggs with antibiotic exceeding standards. The Chinese herbal medicine has the advantages of reducing the using amount of antibiotics in poultry cultivation, improving the body high nonspecific immunity, obviously resisting infection, reducing drug resistance, reducing toxic and side effects, enhancing the anti-stress capability and regulating the metabolism of the body by utilizing Chinese herbal medicines, and has the urgent need to develop and utilize the Chinese herbal medicine preparation to treat the infectious bronchitis of chickens.

Disclosure of Invention

In view of the above situation, in order to solve the problems of the technology, the application provides a traditional Chinese medicine prescription for treating infectious bronchitis of chickens, and the traditional Chinese medicine prescription is used for treating the infectious bronchitis of chickens, and has the effects and characteristics of good heat clearing and detoxifying, antivirus, lung diffusing and phlegm resolving, cough and asthma relieving, body resistance strengthening and body resistance strengthening, nonspecific immunity improving, antibacterial and anti-inflammatory effects, no medicine residue, no toxic or side effect, low cost and difficult recurrence after healing.

A traditional Chinese medicine prescription for treating infectious bronchitis of chickens consists of the following raw materials in parts by weight: 25-30 parts of honeysuckle, 20-25 parts of radix scutellariae, 20-25 parts of fructus forsythiae, 25-28 parts of coptis chinensis, 25-30 parts of fructus gardeniae, 18-20 parts of radix astragali, 20-22 parts of bitter apricot seed, 26-28 parts of platycodon grandiflorum, 18-21 parts of fritillary bulb, 15-16 parts of radix codonopsis, 15-20 parts of liquorice and 15-20 parts of pulsatilla chinensis; 12-15 parts of phellodendron bark and 10-12 parts of houttuynia cordata.

The traditional Chinese medicine prescription for treating infectious bronchitis of chickens, disclosed by the application, comprises the following raw materials in parts by weight: 25-30g of honeysuckle, 20-25g of radix scutellariae, 20-25g of fructus forsythiae, 25-28g of coptis chinensis, 25-30g of fructus gardeniae, 18-20g of radix astragali, 20-22g of bitter apricot seed, 26-28g of platycodon grandiflorum, 18-21g of fritillary bulb, 15-16g of radix codonopsis, 15-20g of liquorice and 15-20g of pulsatilla chinensis; 12-15g of phellodendron bark and 10-12g of houttuynia cordata.

The application relates to a traditional Chinese medicine prescription for treating infectious bronchitis of chickens, which is prepared by the following steps: mixing all the raw materials, performing superfine treatment by a high-speed pulverizer, and completely breaking cell walls of the crude medicinal materials to obtain medicinal powder.

Further, the powder is treated to have a diameter reaching the nanometer level.

After the technology provided by the application is adopted, the traditional Chinese medicine prescription for treating infectious bronchitis and the preparation method thereof have the following beneficial effects: after the traditional Chinese medicine materials are mixed and subjected to superfine treatment by a high-speed pulverizer, cell walls of the crude medicine materials are completely broken, the diameter of the medicine powder reaches the nanometer level, and the original water-insoluble substances can be better dissolved and absorbed in animal bodies, so that the absorption quality of the water-insoluble substances is improved. The traditional Chinese medicine for treating infectious bronchitis has the effects and characteristics of good heat-clearing and detoxicating, antivirus, lung diffusing and phlegm resolving, cough and asthma relieving, body resistance strengthening and constitution consolidating, nonspecific immunity improving, antibacterial and anti-inflammatory effects, no medicine residue, no toxic or side effect, low cost and difficult recurrence after healing.

Detailed Description

Preferred embodiments of the present application will be described below. The following description is provided to aid in the understanding of the exemplary embodiments of the application as defined by the claims and their equivalents. It includes various specific details that aid in understanding, but they are to be considered exemplary only. Accordingly, those skilled in the art will recognize that various changes and modifications may be made to the embodiments described herein without departing from the scope and spirit of the application. Moreover, detailed descriptions of functions or constructions well-known in the art will be omitted for clarity and conciseness of the description.

A traditional Chinese medicine prescription for treating infectious bronchitis of chickens consists of the following raw materials in parts by weight: 25-30g of honeysuckle, 20-25g of radix scutellariae, 20-25g of fructus forsythiae, 25-28g of coptis chinensis, 25-30g of fructus gardeniae, 18-20g of radix astragali, 20-22g of bitter apricot seed, 26-28g of platycodon grandiflorum, 18-21g of fritillary bulb, 15-16g of radix codonopsis, 15-20g of liquorice and 15-20g of pulsatilla chinensis; 12-15g of phellodendron bark and 10-12g of houttuynia cordata.

The preparation method comprises the following steps: mixing all the raw materials, performing superfine treatment by a high-speed pulverizer, and completely breaking cell walls of the crude medicinal materials to obtain medicinal powder with diameter reaching nanometer level.

According to the traditional Chinese medicine prescription for treating infectious bronchitis and the preparation method thereof, after traditional Chinese medicine raw materials are mixed and subjected to superfine treatment by a high-speed pulverizer, cell walls of crude medicinal materials are completely broken, the diameters of medicinal powder reach a nanometer level, and the original water-insoluble substances can be better dissolved and absorbed in animals, so that the absorption quality of the water-insoluble substances is improved. The traditional Chinese medicine for treating infectious bronchitis has the effects and characteristics of good heat-clearing and detoxicating, antivirus, lung diffusing and phlegm resolving, cough and asthma relieving, body resistance strengthening and constitution consolidating, nonspecific immunity improving, antibacterial and anti-inflammatory effects, no medicine residue, no toxic or side effect, low cost and difficult recurrence after healing.

The traditional Chinese medicine prescription for treating infectious bronchitis in chickens, disclosed by the application, comprises the following raw materials: honeysuckle flower is sweet and cold in nature, has the effects of pungent and cool, eliminating pathogenic factors, clearing heat, and removing toxic substances, and is mainly used for treating various infectious diseases such as warm disease fever, heat toxin bloody dysentery, carbuncles, swelling, furuncles and the like; the radix scutellariae is bitter in taste and cold in nature, has the effects of clearing heat and cooling blood and stopping bleeding, and is mainly used for treating damp-heat distention and fullness, diarrhea, cough due to lung heat, high-heat polydipsia, hematemesis and epistaxis, carbuncles and sores; fructus forsythiae is bitter and cool, enters heart, liver and gallbladder meridians, has the effects of clearing heat, removing toxicity, resolving hard mass and detumescence, and is mainly used for treating warm, erysipelas, macula, carbuncle, ulcer and swelling toxin, scrofula and urine stranguria; coptis root has bitter taste, and is effective in relieving flatulence, removing heat and dampness, purging pathogenic fire and removing toxic substances, and can be used for treating high fever unconsciousness, excessive heart fire, vexation and insomnia, hematemesis, epistaxis, conjunctival congestion, diabetes, carbuncle and furuncle; the fructus gardeniae is bitter in nature and cold in nature, has the effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood and detoxifying; the externally applied effects of detumescence and pain relieving are mainly used for treating febrile vexation, damp-heat jaundice, stranguria with astringent pain, hematemesis and epistaxis, conjunctival congestion and swelling pain, fire toxin sore and ulcer, and external treatment of sprain, contusion and pain; astragalus mongholicus is sweet in nature and slightly warm in nature, has the effects of tonifying qi, strengthening exterior, promoting urination, strengthening heart, reducing blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, strengthening resistance of capillaries, and resisting sweat and sex hormone, and is mainly used for treating exterior deficiency spontaneous perspiration, qi deficiency internal injury, spleen deficiency diarrhea, edema, carbuncle and the like; the bitter apricot contains amygdalin which can be hydrolyzed by intestinal microbial enzymes or amygdalin contained in the bitter apricot itself in vivo to generate trace hydrocyanic acid and benzaldehyde, which has the inhibiting effect on respiratory center, achieves the effects of relieving cough and asthma, and the rich fatty oil has the function of relaxing bowel; the platycodon root has sweet taste and cold property, has the effects of dispersing lung qi, relieving sore throat, eliminating phlegm, expelling pus, relieving cough, resisting inflammation and dilating blood vessels, and is mainly used for treating cough with excessive phlegm, chest distress, unsmooth throat pain, hoarseness, pulmonary abscess with pus, sore with pus, no stain and the like; zhejiang Bei Wei bitter; cold in nature, has effects of clearing heat and eliminating phlegm; the Chinese medicinal composition has the effects of resolving stagnation and resolving hard mass, and is mainly used for treating wind heat, dryness heat, phlegm heat cough, scrofula, goiter, sore and carbuncle swelling and lung abscess and the like; the codonopsis pilosula is sweet in taste and flat, has the effects of tonifying middle-jiao and Qi, harmonizing stomach and promoting fluid production, and eliminating phlegm and relieving cough, and is mainly used for treating spleen deficiency, anorexia, loose stool, limb weakness, palpitation, shortness of breath, dry mouth, spontaneous perspiration, rectocele and yin stiffness; the liquorice has sweet nature and flat nature, has the effects of tonifying spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing various medicines, and is mainly used for treating carbuncle and ulcer, sore throat, asthma and cough, gastrocnemius muscle spasm and pain, resisting acid and relieving gastrointestinal smooth muscle spasm; the Chinese pulsatilla root has bitter and cold taste, has the effects of clearing heat and detoxicating, cooling blood and stopping dysentery, and is mainly used for treating heat toxin bloody dysentery, pruritus vulvae and leukorrhagia; huang Baiwei it has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steaming, removing toxic substances, and treating sore, and is mainly used for treating damp-heat dysentery, jaundice, dark urine, itching, stranguria due to heat, tinea pedis, debility due to bone steaming, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema; herba Houttuyniae is pungent and slightly cold in flavor, has the effects of clearing heat and removing toxicity, removing carbuncles and expelling pus, and inducing diuresis and treating stranguria, and is mainly used for treating pulmonary abscess with purulent vomiting, phlegm-heat asthma and cough, heat dysentery, heat stranguria, carbuncles and swelling sore toxin.

According to the traditional Chinese medicine prescription for treating infectious bronchitis of chickens, honeysuckle, fructus forsythiae and astragalus are monarch drugs, so that the traditional Chinese medicine prescription has the effects of pungent and cool, pathogenic factors clearing and heat clearing, has the effects of aromatic, dirt-removing and detoxifying, is supplemented with coptis chinensis and radix scutellariae as ministerial drugs, assists in monarch drug evil and enhances the effects of clearing heat and detoxifying, has the effects of clearing heat and cooling blood, has the effects of clearing heat and resolving phlegm, resolving depression and resolving masses, has the effects of strengthening body resistance and consolidating constitution of astragalus and radix codonopsis, and improves immunity, and has the effect of relieving cough and asthma of bitter almonds. The platycodon grandiflorum has the effects of dispersing lung qi, relieving sore throat, removing phlegm, and the liquorice has the effects of clearing heat and detoxicating, and the platycodon grandiflorum and the liquorice can dispel the accumulation of chest and diaphragm and ascend, and the platycodon grandiflorum and the liquorice are matched with the thunberg fritillary bulb, the pulsatilla chinensis, the phellodendron bark and the houttuynia cordata to have the effects of eliminating carbuncles, expelling pus, promoting diuresis, stopping leukorrhagia, promoting blood circulation, promoting urination and treating stranguria, so that the platycodon grandiflorum and the liquorice are adjuvant and guiding drugs, and the aim of thoroughly curing the infectious bronchitis of chickens is achieved.

According to the traditional Chinese medicine prescription for treating infectious bronchitis of chickens, the efficacy characteristics of the Chinese herbal medicines are compounded, and the traditional Chinese medicine prescription has the effects and characteristics of good heat clearing and detoxifying, antivirus, lung diffusing and phlegm resolving, cough relieving and asthma relieving, body resistance strengthening and body resistance strengthening, non-specific immunity improving, antibacterial and anti-inflammatory effects, no medicine residue, no toxic or side effect, low cost and difficult recurrence after healing.

Taking 30 loving-Viing broilers of the uniform breeding house at the age of 25 days to divide into three groups for detoxification, obtaining three experimental groups of A, B, C groups respectively, respectively carrying out corresponding treatment by using traditional antibiotics ciprofloxacin and enrofloxacin which are mixed with 0.001% of raw materials and superfine powder which is prepared by using the traditional Chinese medicine formula of the application, and carrying out continuous 8-day treatment comparison to obtain the following experimental data:

group of	A (ciprofloxacin group)	B (enrofloxacin group)	C (traditional Chinese medicine prescription superfine powder)
				Experiment number (only)	30	30	30
Number of attacks (Only)	24	24	25
				Incidence (%)	80.0	80.0	83.3
Survival number (only)	21	22	30
				Number of deaths (only)	9	8	0
Mortality (%)	30.0	26.6	0
				Survival (%)	70.0	73.4	100
Time of obvious effect (Tian)	7	7	5
				Symptom vanishing time (Tian)	12	11	7

Experimental data shows that the traditional Chinese medicine formula has incomparable advantages of the other two groups of traditional Chinese medicine formulas and the antibiotic ciprofloxacin in the aspect of survival rate, survival number, effective time and symptom disappearance time compared with those of A, B groups.

The traditional Chinese medicine prescription for treating infectious bronchitis in chickens has the advantages of good effects and characteristics of clearing heat and detoxicating, resisting viruses, ventilating lung and resolving phlegm, relieving cough and asthma, strengthening body resistance and consolidating constitution, improving nonspecific immunity, resisting bacteria and diminishing inflammation, having no drug residues, having no toxic or side effect, being low in cost and not easy to relapse after healing.

The traditional Chinese medicine prescription is applied and popularized in a 7-year clinical practice in a broiler farm, and treats 78 ten thousand broilers with infectious bronchitis, so that a good treatment effect is obtained, and good economic benefit and ecological benefit are obtained. The following is the comparison analysis of 10000 chickens as comparison unit parameters and the traditional antibiotic treatment benefit in the application process:

2013-2020 traditional Chinese medicine formula, ciprofloxacin antibiotic and antibiotic

Enrofloxacin treatment cost, generated economic benefit and drug residue comparison table

Units: ten thousands of things

The foregoing has outlined rather broadly the more detailed description of the application in order that the detailed description of the principles and embodiments of the application may be implemented in conjunction with the detailed description of the application that follows, the examples being merely intended to facilitate an understanding of the method of the application and its core concepts; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in accordance with the ideas of the present application, the present description should not be construed as limiting the present application in view of the above.

From the description of the embodiments above, it will be apparent to those skilled in the art that the application may be practiced. Of course, the above listed cases are only examples, and the present application is not limited thereto. Those skilled in the art will appreciate that other variations or simplifications of the inventive solution may be suitably employed in the present application and are intended to be included within the scope of the present application.

Claims

1. The traditional Chinese medicine composition for treating the infectious bronchitis of chickens is characterized by comprising the following raw materials in parts by weight: 25-30g of honeysuckle, 20-25g of radix scutellariae, 20-25g of fructus forsythiae, 25-28g of coptis chinensis, 25-30g of fructus gardeniae, 18-20g of radix astragali, 20-22g of bitter apricot seed, 26-28g of platycodon grandiflorum, 18-21g of thunberg fritillary bulb, 15-16g of radix codonopsis, 15-20g of liquorice, 15-20g of Chinese pulsatilla root, 12-15g of cortex phellodendri and 10-12g of herba houttuyniae; the preparation method comprises mixing all the raw materials, performing superfine treatment by a high-speed pulverizer, and completely breaking cell walls of crude medicinal materials to obtain medicinal powder; the powder is processed to reach the nanometer level in diameter.