CN104906390A - Medicine for treating occupational chronic lead poisoning caused by spleen-stomach disharmony and preparation method - Google Patents

Abstract

The invention discloses a medicine for treating occupational chronic lead poisoning caused by spleen-stomach disharmony and a preparation method. The medicine comprises the following medicinal materials: valeriana jatamansi, uraria crinita, mentha spicata, camphorwood seed, eupatorium japonicum, gnaphalium tranzschelii, bushy dasiphora flower, diuranthera major, dracontomelon duperreanum, desmodium triquetrum, dendrobe, arisaema intermedium blume, helwingia root, podophyllum hexandrum, polygonum chinense, adiantum capillus-veneris, lithospermum, garden balsam stem, fructus polygoni orientalis, kamuning, herba pyrolae, peperomia blanda, ternate buttercup root, marsdenia tinctoria, acmella ciliate, indian lettuce, creeping violet herb, centella, nude pronephrium rhizome, ovateleaf holly bark and liquorice. According to the medicine disclosed by the invention, the traditional Chinese medicinal materials with different medicine properties are scientifically combined to achieve the effects of detoxifying, regulating vital energy, regulating the middle warmer, calming the adverse-rising energy, accelerating poison discharge and treating both symptoms and root causes; the medicine is safe, effective, relatively few in adverse effects and relatively short in treatment course; the preparation technology of the medicine is simple, convenient and low in cost; and the occupational chronic lead poisoning is not easy to recur after being cured.

Description

The medicine for the treatment of incoordination between the spleen and stomach type occupational chronic lead poisoning and preparation method

Technical field

The present invention relates to pharmaceutical technology, particularly treat medicine and the preparation method of incoordination between the spleen and stomach type occupational chronic lead poisoning.

Background technology

Improving constantly and the fast development of economy in recent years along with social science and technology's level, professional lead poisoning case showed increased.Lead poisoning often causes human body multiple organ system damage, mainly lead enters blood circulation after being absorbed with ionic condition, mainly at first respectively to organize in whole body with lead salt and the formal distribution that is combined with plasma protein, 95% is about had to be deposited on skeletal system and hair with insoluble lead phosphate after several weeks, only there is the lead of about 5% to retain in the organs such as liver, kidney, brain and blood, cause anemia, haemolysis, lead encephalopathy and peripheral neuropathy and kidney injury.

Occupational Exposure is common in plumbous smelting, alloy manufacturing industry, accumulator industry, printing typeofounding, metal solder and fusion cutting, lead, radio component and sprays lead, bearing tile hanging, pottery, cloisonné technique, pigment industry and rubber plastic industry etc.These operations are after the flue dust sucking plumbous and compound mostly, enter human body and poisoning by pulmonary circulation.There is explicit stipulation in country to the maximum permissible concentration of harmful substance in workshop air, and as workshop lead fume content should lower than 0.03mg/m3, lead dust should lower than 0.05mg/m3.Some production station then often exceeds this normal concentration, even exceedes this concentration several times or decades of times.Most personal entity lead refinery and printing industry condition simple and crude, to occupational hazards protection aspect less investment, various occupational health management system and protective equipment unsound, production environment is poor, add that worker lacks self-protection consciousness, do not note Personal hygiene thus cause professional lead poisoning.

Different according to poisoning rear performance, the traditional Chinese medical science is divided into following a few type: qi stagnation and blood stasis type, incoordination between the spleen and stomach type, spleen-stomach deficiency-cold, qi and blood deficiency and liver-kidney yin deficiency; Wherein incoordination between the spleen and stomach type performance distension and fullness in the abdomen, belch, singultus, poor appetite, pale tongue with white fur band are greasy, stringy and hesitant pulse.

Western medical treatment lead poisoning mainly drives plumbous method, is simultaneously easily discharged together by other trace element.

Chinese medicine lead poisoning utilizes Traditional Chinese medical theory, the ability of enhancing body defence pathogenic factor, and solid protection healthy energy, passes through determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, get rid of toxin, alleviate the toxic and side effects of western modern medicine, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and the course for the treatment of is shorter, convenient drug administration, and patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind ofly to have removing toxic substances and regulate the flow of vital energy and the medicine of middle sending down the abnormal ascending QI effect, is used for the treatment of incoordination between the spleen and stomach type occupational chronic lead poisoning.The present invention utilizes Traditional Chinese medical theory, the ability of enhancing body defence pathogenic factor, and get rid of toxin, alleviate the toxic and side effects of western modern medicine, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and treatment time is shorter, convenient drug administration, and patient is easy to accept, and improves cure rate.

In order to realize foregoing invention object, the invention provides a kind of medicine for the treatment of incoordination between the spleen and stomach type occupational chronic lead poisoning, comprise following raw medicinal material: Rhizoma valerianae latifoliae, Herba Urariae crinitae, Herba Menthae Rotundifoliae, Lignum cinnamomi camphorae, mountain Herba Eupatorii, Herba Gnaphalii uliginosi, Dasiphora fruticosa (L.) Rydb., Radix diurantherae majoris, Fructus Dracontomeli Duperreani, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Dendrobii, Arisaema intermedium Blume, Radix Helwingiae, Chinese podophyllum root, Herb Polygoni Chinensis, Herba Adianti, Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Fructus Polygoni Orientalis, Folium Et Cacumen Murrayae, Herba Pyrolae, Herba Peperomiae Dindygulensis, Radix Ranunculi Ternati, Caulis Marsdeniae tinctoriae, Herba Spilanthis Acmellae, Herba Ixeritis Denticulatae, Herba Violae Serpentis, Herba Centellae, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Cortex Ilicis Rotundae and Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 10-16 part, Herba Urariae crinitae 15-23 part, Herba Menthae Rotundifoliae 9-18 part, the sub-12-24 part of Lignum cinnamomi camphorae, mountain Herba Eupatorii 17-29 part, Herba Gnaphalii uliginosi 8-17 part, Dasiphora fruticosa (L.) Rydb. 14-22 part, Radix diurantherae majoris 19-27 part, Fructus Dracontomeli Duperreani 12-18 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-25 part, Herba Dendrobii 28-38 part, Arisaema intermedium Blume 4-11 part, Radix Helwingiae 10-17 part, Chinese podophyllum root 3-8 part, Herb Polygoni Chinensis 4-9 part, Herba Adianti 16-24 part, Radix Arnebiae (Radix Lithospermi) 20-38 part, Herba speranskiae tuberculatae 3-7 part, Fructus Polygoni Orientalis 26-36 part, Folium Et Cacumen Murrayae 2-7 part, Herba Pyrolae 10-20 part, Herba Peperomiae Dindygulensis 21-26 part, Radix Ranunculi Ternati 16-30 part, Caulis Marsdeniae tinctoriae 13-23 part, Herba Spilanthis Acmellae 4-10 part, Herba Ixeritis Denticulatae 12-22 part, Herba Violae Serpentis 13-27 part, Herba Centellae 16-25 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 10-18 part, Cortex Ilicis Rotundae 12-25 part and Radix Glycyrrhizae 12-17 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 11-15 part, Herba Urariae crinitae 17-21 part, Herba Menthae Rotundifoliae 10-16 part, the sub-14-22 part of Lignum cinnamomi camphorae, mountain Herba Eupatorii 18-27 part, Herba Gnaphalii uliginosi 9-15 part, Dasiphora fruticosa (L.) Rydb. 16-20 part, Radix diurantherae majoris 20-25 part, Fructus Dracontomeli Duperreani 13-17 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12-22 part, Herba Dendrobii 29-36 part, Arisaema intermedium Blume 5-10 part, Radix Helwingiae 11-15 part, Chinese podophyllum root 4-7 part, Herb Polygoni Chinensis 5-8 part, Herba Adianti 18-22 part, Radix Arnebiae (Radix Lithospermi) 21-35 part, Herba speranskiae tuberculatae 4-6 part, Fructus Polygoni Orientalis 28-34 part, Folium Et Cacumen Murrayae 3-6 part, Herba Pyrolae 11-19 part, Herba Peperomiae Dindygulensis 22-25 part, Radix Ranunculi Ternati 18-26 part, Caulis Marsdeniae tinctoriae 15-20 part, Herba Spilanthis Acmellae 5-9 part, Herba Ixeritis Denticulatae 13-20 part, Herba Violae Serpentis 14-24 part, Herba Centellae 18-23 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12-16 part, Cortex Ilicis Rotundae 14-23 part and Radix Glycyrrhizae 13-16 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 14 parts, Herba Urariae crinitae 19 parts, Herba Menthae Rotundifoliae 10 parts, Lignum cinnamomi camphorae 14 parts, mountain Herba Eupatorii 27 parts, Herba Gnaphalii uliginosi 15 parts, Dasiphora fruticosa (L.) Rydb. 16 parts, Radix diurantherae majoris 25 parts, Fructus Dracontomeli Duperreani 17 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12 parts, Herba Dendrobii 36 parts, Arisaema intermedium Blume 10 parts, 11 parts, Radix Helwingiae, Chinese podophyllum root 6 parts, Herb Polygoni Chinensis 5 parts, Herba Adianti 22 parts, Radix Arnebiae (Radix Lithospermi) 35 parts, Herba speranskiae tuberculatae 5 parts, Fructus Polygoni Orientalis 34 parts, Folium Et Cacumen Murrayae 3 parts, Herba Pyrolae 19 parts, Herba Peperomiae Dindygulensis 24 parts, Radix Ranunculi Ternati 23 parts, Caulis Marsdeniae tinctoriae 15 parts, Herba Spilanthis Acmellae 8 parts, Herba Ixeritis Denticulatae 13 parts, Herba Violae Serpentis 24 parts, Herba Centellae 22 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 15 parts, Cortex Ilicis Rotundae 14 parts and 15 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 15 parts, Herba Urariae crinitae 17 parts, Herba Menthae Rotundifoliae 16 parts, Lignum cinnamomi camphorae 22 parts, mountain Herba Eupatorii 18 parts, Herba Gnaphalii uliginosi 12 parts, Dasiphora fruticosa (L.) Rydb. 18 parts, Radix diurantherae majoris 20 parts, Fructus Dracontomeli Duperreani 16 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 parts, Herba Dendrobii 31 parts, Arisaema intermedium Blume 5 parts, 13 parts, Radix Helwingiae, Chinese podophyllum root 4 parts, Herb Polygoni Chinensis 8 parts, Herba Adianti 18 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, Herba speranskiae tuberculatae 6 parts, Fructus Polygoni Orientalis 32 parts, Folium Et Cacumen Murrayae 6 parts, Herba Pyrolae 11 parts, Herba Peperomiae Dindygulensis 25 parts, Radix Ranunculi Ternati 26 parts, Caulis Marsdeniae tinctoriae 16 parts, Herba Spilanthis Acmellae 9 parts, Herba Ixeritis Denticulatae 18 parts, Herba Violae Serpentis 14 parts, Herba Centellae 23 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 16 parts, Cortex Ilicis Rotundae 23 parts and 13 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 11 parts, Herba Urariae crinitae 21 parts, Herba Menthae Rotundifoliae 13 parts, Lignum cinnamomi camphorae 18 parts, mountain Herba Eupatorii 22 parts, Herba Gnaphalii uliginosi 9 parts, Dasiphora fruticosa (L.) Rydb. 20 parts, Radix diurantherae majoris 24 parts, Fructus Dracontomeli Duperreani 13 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22 parts, Herba Dendrobii 29 parts, Arisaema intermedium Blume 8 parts, 15 parts, Radix Helwingiae, Chinese podophyllum root 7 parts, Herb Polygoni Chinensis 6 parts, Herba Adianti 21 parts, Radix Arnebiae (Radix Lithospermi) 21 parts, Herba speranskiae tuberculatae 4 parts, Fructus Polygoni Orientalis 28 parts, Folium Et Cacumen Murrayae 4 parts, Herba Pyrolae 14 parts, Herba Peperomiae Dindygulensis 22 parts, Radix Ranunculi Ternati 18 parts, Caulis Marsdeniae tinctoriae 20 parts, Herba Spilanthis Acmellae 5 parts, Herba Ixeritis Denticulatae 20 parts, Herba Violae Serpentis 17 parts, Herba Centellae 18 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12 parts, Cortex Ilicis Rotundae 18 parts and 16 parts, Radix Glycyrrhizae.

In order to realize goal of the invention better, the invention provides a kind of preparation method for the treatment of the medicine of incoordination between the spleen and stomach type occupational chronic lead poisoning, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrate and after drying, put into super micron mill and pulverize 40 ~ 60 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

In order to realize goal of the invention better, the invention provides a kind of preparation method for the treatment of the medicine of incoordination between the spleen and stomach type occupational chronic lead poisoning, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

In order to realize goal of the invention better, the invention provides a kind of preparation method for the treatment of the medicine of incoordination between the spleen and stomach type occupational chronic lead poisoning, when the dosage form of described medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

For solving the problems of the technologies described above, the present invention also provides a kind of medicine for the treatment of incoordination between the spleen and stomach type occupational chronic lead poisoning, and pharmaceutical dosage form is: tablet, film coated tablet, enteric coated tablet, sugar coated tablet, capsule, soft capsule, oral liquid, hard capsule, suck agent, electuary, honey pill agent, granule, powder, sublimed preparation, solution, syrup, ointment, injection, liniment, ointment, fumigant, patch, suppository, tincture, plaster, gel and spray.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention, adopts the Chinese crude drug of different properties, carries out scientific compatibility, can detoxify and regulate the flow of vital energy, with middle sending down the abnormal ascending QI, accelerate poisonous substance excretion, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and the course for the treatment of is shorter, and pharmaceutical production simple process, with low cost, not easily recur after healing.

Detailed description of the invention

Occupational chronic lead poisoning pathogenesis is mainly after lead is absorbed with ionic condition and enters blood circulation, mainly at first respectively to organize in whole body with lead salt and the formal distribution that is combined with plasma protein, 95% is about had to be deposited on skeletal system and hair with insoluble lead phosphate after several weeks, only there is the lead of about 5% to retain in the organs such as liver, kidney, brain and blood, cause anemia, haemolysis, lead encephalopathy and peripheral neuropathy and kidney injury.

Incoordination between the spleen and stomach type is that evil poison hindered, in impairing the spleen and stomach caused by gas.Therefore the present invention treats incoordination between the spleen and stomach type occupational chronic lead poisoning, regulate the flow of vital energy with removing toxic substances and middle sending down the abnormal ascending QI for primary treatment principle, therefore select prescription: Rhizoma valerianae latifoliae, Herba Urariae crinitae, Herba Menthae Rotundifoliae, Lignum cinnamomi camphorae, mountain Herba Eupatorii, Herba Gnaphalii uliginosi, Dasiphora fruticosa (L.) Rydb., Radix diurantherae majoris, Fructus Dracontomeli Duperreani, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Dendrobii, Arisaema intermedium Blume, Radix Helwingiae, Chinese podophyllum root, Herb Polygoni Chinensis, Herba Adianti, Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Fructus Polygoni Orientalis, Folium Et Cacumen Murrayae, Herba Pyrolae, Herba Peperomiae Dindygulensis, Radix Ranunculi Ternati, Caulis Marsdeniae tinctoriae, Herba Spilanthis Acmellae, Herba Ixeritis Denticulatae, Herba Violae Serpentis, Herba Centellae, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Cortex Ilicis Rotundae and Radix Glycyrrhizae.

Wherein, Rhizoma valerianae latifoliae, Herba Urariae crinitae, Herba Menthae Rotundifoliae, Lignum cinnamomi camphorae, mountain Herba Eupatorii, Herba Gnaphalii uliginosi regulating the flow of Qi and the middle Jiao; Dasiphora fruticosa (L.) Rydb., Radix diurantherae majoris, Fructus Dracontomeli Duperreani, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Dendrobii, Arisaema intermedium Blume invigorating the spleen and replenishing QI; Radix Helwingiae, Chinese podophyllum root, Herb Polygoni Chinensis, Herba Adianti promoting blood circulation and detoxication; Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Fructus Polygoni Orientalis, Folium Et Cacumen Murrayae are invigorated blood circulation; Herba Pyrolae is enriched blood; Herba Peperomiae Dindygulensis, Radix Ranunculi Ternati, Caulis Marsdeniae tinctoriae blood stasis-eliminating and stagnation-dissipating; Herba Spilanthis Acmellae, Herba Ixeritis Denticulatae, Herba Violae Serpentis reducing swelling and alleviating pain; Herba Centellae, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching regulating QI to expel dampness; Cortex Ilicis Rotundae removing toxic substances pain relieving; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Rhizoma valerianae latifoliae: another name Herba Asari, TUXIXIN, lobus cardiacus Rhizoma et radix valerianae, lotus of nourishing heart, lotus of nourishing blood, smelly medicine, Wu Can, Radix decaisneae fargesii, tiger seven, Rhizoma et radix valerianae Valerianaceae valerian Aranea grass, is used as medicine with root stock and root.Pungent, micro-hardship, temperature.Promoting digestion and invigorating the stomach, regulating QI to relieve pain, removing toxic substances of dispeling the wind.Stomachache abdominal distention, dyspepsia, infantile malnutrition, gastroenteritis, dysentery, rheumatalgia, soreness of the waist and knees.

Herba Urariae crinitae: another name Herba Urariae Lagopodioidis, timothy grass (" Guangxi Chinese medicinal herbal "), system sky grass (" the south of Fujian Province traditional herbal medicine "), university degree mountain cyanines, ancient coin window grass, the golden mace of ferrum (" Quanzhou book on Chinese herbal medicine "), Canis familiaris L. tail is penetrated (" Fujian Chinese herbal medicine ").For the herb that leguminous plant cat tail is penetrated.Sweet; Micro-hardship; Flat.GUIXIN; Lung; Liver Channel.Clearing away lung-heat to relieve cough; Dissipating blood stasis stops blooding.Main cough due to lung-heat; Lung abscess; Gather; Acute mastitis; Proctoptosis; Uterine prolapse; Spit blood; Hematuria; Traumatic hemorrhage.1. " the south of Fujian Province traditional herbal medicine ": moisturize antipyretic, eliminating carbuncle removing toxic substances.2. " Guangxi Chinese herbal medicine ": dissipating blood stasis stops blooding, clearing and antitussive.Control haematemesis, spitting of blood, hematuria, knife injury is hemorrhage, cough due to lung-heat, uterine prolapse, proctoptosis.3. LongXi " practical Chinese herbal medicine ": promoting blood circulation to remove obstruction in the collateral, regulating the flow of Qi and the middle Jiao.Control gastric and duodenal ulcers, pulmonary tuberculosis, leucorrhea, arthritis, infantile malnutrition.

Herba Menthae Rotundifoliae: another name Mentha spicata L., Mentha viridis L, blue or green Herba Menthae, tomentosecalyx elsholtzia leaf.Labiatae mint Herba Menthae Rotundifoliae, with all herbal medicine.Pungent, sweet, tepor.Expelling wind and cold, cough-relieving, subduing swelling and detoxicating.For cold cough, stomachache, abdominal distention, nervous headache; Treating swelling and pain by traumatic injury is controlled in external, eye conjunctivitis, children's's furuncle.Dispelling wind, regulates the flow of vital energy, pain relieving.For flu, cough, headache, abdominal distention, dysmenorrhea.Induce sweat; With in; Regulate the flow of vital energy.

Lignum cinnamomi camphorae: another name Camphor tree button, Camphor tree, Lignum cinnamomi camphorae are cool, Fructus litseae rubescentis.Medical material Ji Yuan: be the mature fruit of canella Camphor tree.Pungent; Temperature.Expelling wind and cold; Stomach warming and in; Regulating QI to relieve pain.Main coldness and pain in the epigastrium; Cold-damp is vomited and diarrhoea; Stagnation of QI abdominal distention; Beriberi.

Mountain Herba Eupatorii: another name hoary hair mother-in-law, Herba Eupatorii, southern Herba Eupatorii, Herba eupatorii japonici, Radix ceratostigmatis willemottiani, Rhizoma cimicifugae simplicis, the numb arm beam of steelyard, Eupatorium lindleyanum D C., Herba Eupatorii Heterophylli, Radix Pouzolziae Sanguineae, Herba Lycopi, blood Rhizoma Cimicifugae, thin Radix vernoniae asperae, Herba Eupatorii.Medical material Ji Yuan: be the herb of the single Ye Peilan of feverfew.Acrid in the mouth; Bitter; Property is put down.Drive away summer heat and deliver; Removing dampness for regulating stomach; Vital energy regualting and blood circulation-promoting; Removing toxic substances.Main Sunstroke by every means wets; Fever and headache; The vexed abdominal distention of born of the same parents; Dyspepsia; Gastroenteritis; Sense stomach; Cough; Pharyngolaryngitis; Tonsillitis; Menoxenia; Traumatic injury; Carbuncle; Venom.

Herba Gnaphalii uliginosi: another name ecthyma grass, swamp cudweed.Compositae cottonweed Herba Gnaphalii uliginosi, with all herbal medicine.Sweet, flat.Relieving cough and asthma, regulating QI to relieve pain, blood pressure lowering.For cough and asthma, bronchitis, rheumatalgia, gastric ulcer, hypertension.

Dasiphora fruticosa (L.) Rydb.: another name arteries and veins leaf Folium seu Semen Daphniphylli oldhami, Daphniphyllum paxianum Rosanth.Medical material Ji Yuan: be the flower of rosaceous plant bush cinqefoil.Bitter; Cool.Return spleen; Stomach; Liver Channel.Removing dampness spleen invigorating.Main dampness taste; Inappetence; Body and face edema; Leucorrhea with red and white discharge, mastitis.

Radix diurantherae majoris: another name Herba Allii bulleyani, Diuranthera Hemsl, Silene tatarinowii Regel-Melandrium tatarinwiii (Regel) Tsui..Liliaceae Radix diurantherae majoris, is used as medicine with root.Sweet in the mouth; Property is put down.Eliminating stasis to stop pain; Hemostasia and promoting granulation.Main traumatic injury; Traumatic hemorrhage.

Fructus Dracontomeli Duperreani: another name people face fruit.Anacardiaceae Fructus Dracontomeli Duperreani, is used as medicine with fruit.Acid, cool.Return spleen; Stomach; Liver Channel.Strengthening the spleen to promote digestion, promoting the production of body fluid to quench thirst.Cure mainly dyspepsia, inappetence, calentura is thirsty.Rotten skin ulcer is controlled in external, decubital ulcer.Stomach invigorating; Promote the production of body fluid; Relieving alcoholic intoxication; Removing toxic substances.Main inappetence; Calentura is thirsty; Drunk; Laryngopharynx swelling and pain; Pathogenic wind-toxic sore is itched.

Herba Desmodii Triquetri (Herba Tadehagi Triquetri): another name razor handle, Cordyceps, Anisomeles indica (L.) Kuntze, cured fish grass, hundred labor tongues, Manitis tongue.Pulse family beggar-ticks plant gourd tea, is used as medicine with Herb.Micro-hardship, puckery, cool.Heat-clearing and toxic substances removing, removing food stagnancy dampness removing, parasite killing is anticorrosion.For preventing heatstroke, cold, fever, laryngopharynx swelling and pain, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, Fructus Ananadis comosi is poisoning, children's's scleroderma.

Herba Dendrobii: be the stem of orchid Dendrobium nobile or its multiple congener.Sweet, be slightly cold.Return stomach, kidney channel.Reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.

Arisaema intermedium Blume: another name Rhizoma Arisaematis Intermedii.Araeceae Arisaema intermedium Blume, is used as medicine with tuber.Pungent, temperature.Drying dampness to eliminate phlegm, stomach function regulating spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI.Cure mainly gastritis, gastric ulcer is vomitted, cough, abundant expectoration, the diseases such as hyperemesis.

Radix Helwingiae: Radix Helwingiae: another name Radix Tiliae (" Guizhou medical herbs "), Helwingia himalaica root (" Yunnan Chinese herbal medicine ").For the blue or green pod leaf of Cornaceae plant, the root of the blue or green pod leaf in Tibet or Helwingia chinensis.Toil, flat.1. " Guizhou medical herbs ": " property is put down, and acrid in the mouth is micro-sweet." 2. " Yunnan Chinese herbal medicine ": " is bitter micro-puckery, cool." antiasthmatic-antitussive, blood circulation promoting and blood stasis dispelling.Control cough with asthma, rheumatism, impairment caused by overstrain, menoxenia, traumatic injury. 1. " Guizhou medical herbs ": " pain relieving, Gu de-for tonify deficiency, cough-relieving." 2. " Yunnan Chinese herbal medicine ": " blood circulation promoting and blood stasis dispelling, synthetism, preventing the attack (or recurrence) of malaria." 3. " Kunming conventional medical herbs among the people ": " wind-damp dispelling, promoting blood circulation by removing blood stasis.Dispelling the wind and dampness pathogens pain, traumatic injury."

Chinese podophyllum root: another name Radix Podophylli (Fructus Podophylli), Fructus Sinopodophylli.For Berberidaceae plant Rhizoma Dysosmae Versipellis, be used as medicine with root and root stock.Bitter; Micro-pungent; Warm in nature.Expelling wind and removing dampness, cough-relieving pain relieving, promoting blood circulation and detoxication.For rheumatic arthritis, traumatic injury, the heart is had a stomachache, cough due to wind and cold, menoxenia, separates Radix aconiti szechenyiani poisoning.

Herb Polygoni Chinensis: another name Linesless charcoal hair (" the SHENGCAO property of medicine is standby to be wanted "), crow charcoal (Lengthy Compilation of Plants with Illustrations), fortune medicine (" classifying herbal "), Polygonum aubertii grass (" Fujian traditional herbal medicine "), Ramulus et folium berchemiae floribundae, dizzy medicine (" Traditional Chinese Medicine in Sichuan will ").For the herb of polygonaceae plant Herb Polygoni Chinensis.Pungent; Bitter; Cool in nature; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Suppressing the hyperactive liver improving eyesight; Relaxing muscles and tendons to promote blood circulation.Main dysentery; Have loose bowels; Laryngopharynx swelling and pain; Diphtheria; Cough due to lung-heat; Pertussis; Hepatitis; Leukorrhagia; Cancerous protuberance; Otitis media; Eczema; Vertigo and tinnitus; Corneal nebula; Traumatic injury.

Herba Adianti: another name venushair fern, Herba cynodontis, water Pilus Sus domestica seven, Pilus Sus domestica seven, Shi Zhongzhu, black foot awns, iron wire grass.Adiantaceae Adiantum plant iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb., with all herbal medicine.Light, cool.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cold, fever, cough spitting of blood, hepatitis, enteritis, dysentery, urinary tract infection, acute nephritis, mastitis; Furuncle is controlled in external, burn and scald.

Radix Arnebiae (Radix Lithospermi): another name gromwell root, Radix Arnebiae.This product is comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi). or the dry root of arnebia guttata Bunge.Sweet, salty, cold.GUIXIN, Liver Channel.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.

Herba speranskiae tuberculatae: the herb of Euphorbiaceae Speranskia plant speranskia tuberculata, Balsaminaceae herbaceous plant Flos Impatientis, Bignoniaceae Incarvillea AJuss plant Herba Incarvilleae sinensis, pulse family Vetch plant Herba Viciae Amoenae and the Herb of Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis.Pungent, bitter, temperature.Return liver, kidney channel.Expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis; Sore swollen toxin is controlled in external.

Fructus Polygoni Orientalis: another name prince's-feather, sky knotweed, Canis familiaris L. tail flower, Herba lysimachiae.This product is the dry mature fruit of polygonaceae plant smartweed.Salty, be slightly cold.Return liver, stomach warp.Loose blood eliminating mass, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, goiter swells and ache, and food stagnation does not disappear, epigastric distending pain.

Folium Et Cacumen Murrayae: this product is dried leaves and the band leaf twig of rutaceae Folium Et Cacumen Murrayae and Murraya paniculata (L.) Jack..Pungent, micro-hardship, temperature.Promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.For stomachache, rheumatic arthralgia; External treatment is had a toothache, tumbling and swelling, worm venom.Anesthesia, relieving convulsion, removing toxic substances and promoting subsidence of swelling, dispelling, collateral-activating.Cure mainly treating swelling and pain by traumatic injury, rheumatic ostalgia, stomachache, toothache, tetanus, epidemic encephalitis type B, worm, venom, local anesthesia.

Herba Pyrolae: another name Herba pyrolae japonicae, Herba Pyrolae, deer peace tea, Herba pyrolae japonicae, checkerberry, Pyrola rotundifolia ssp.chinensis, Herba Polygalae Telephioidis [Sichuan].This product is the dry herb of Pyrolaceae plant Herba pyrolae japonicae or ovum leaf Herba pyrolae japonicae.Sweet, bitter, temperature.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.

Herba Peperomiae Dindygulensis: another name burn leaf, peppergrass (" register planted by Guangxi medicine "), loose blood gallbladder, Semen Sojae Preparatum seven, Radix Ardisiae Punctatae, Shi Macai (" choosing of Yunnan Chinese herbal medicine "), Herba Seu Radix Peperomiae Tetraphyllae, Semen Phaseoli lobe (" choosing of Simao, Yunnan Chinese herbal medicine ").[source] is the herb of Piperaceae plant Herba Peperomiae Dindygulensis.Pungent; Cool.Return lung; Spleen; Liver; Kidney channel.Heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis.

Radix Ranunculi Ternati: another name Seynuns Kugelann.This product is the dried root of ranunculaceae plant Seynuns Kugelann.Sweet, acrid, warm.Return liver, lung meridian.Eliminating stagnation, detumescence., tuberculous lymphadenitis not routed for scrofula.

Caulis Marsdeniae tinctoriae: another name Xiao the ears of an ox or cow dish, Xiao's the ears of an ox or cow rattan, swordweed [Guangxi].Asclepiadaceae Caulis Marsdeniae tinctoriae is used as medicine with fruit.Acrid in the mouth, hardship, warm in nature.Liver, stomach two warp.Expelling wind and removing dampness; Blood stasis-eliminating and stagnation-dissipating.Main rheumatic ostalgia; Hepatomegaly.

Herba Spilanthis Acmellae: call mountain Herba Spilanthis Acmellae, Herba boeae clarkeanae, umbrella grass, golden button, Cymbaria dahurica, Hemerocallis citrina Baroni Herba vallisneriae Spiralis, Herba vallisneriae Spiralis, cross Solenognathus, mountain Cortex Lycii, black joint pass.Compositae gold button platymiscium Herba Spilanthis Acmellae, with all herbal medicine.Pungent, temperature.Detoxification and promoting urination, relieving cough and relieving asthma, reducing swelling and alleviating pain.For malaria, toothache, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis.Venom is controlled in external, dog bite, carbuncle furuncle and phyma poison.

Herba Ixeritis Denticulatae: another name dish grass (" Shaanxi Chinese herbal medicine ").For the herb of feverfew Herba Ixeritis Denticulatae.Bitter in the mouth; Cold in nature.Heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main carbuncle furuncle parent poison; Acute mastitis; Laryngopharynx swelling and pain; Jaundice; Dysentery; Stranguria; Leukorrhagia; Traumatic injury.

Herba Violae Serpentis: another name Viola grypoceras A. Gray, Herba Violae Serpentis.Medical material Ji Yuan: for Violaceae plant crawls the herb of common violet.Bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main sore swollen toxin; Poison rope bites; Knife injury.

Herba Centellae: another name collapses jorum, Herba Calthae Membranaceae, Gotu Kola, Carnis Arca inflata shell grass, Hydrocotyle vulgaris L., Herba sambuci chinensis.This product is the dry herb of samphire Herba Centellae.Bitter, acrid, cold.Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.

Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching: call large plumage crescent Herba pteridii latiusculi, Coniogramme japonica (Thunb.) Diels.Fern Athyriaceae Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching is used as medicine with root stock.Hardship, cold.Dredge the meridian passage, dampness removing of regulating the flow of vital energy.Cure mainly impairment caused by overstrain, peratodynia, dysentery, menoxenia.

Cortex Ilicis Rotundae: another name silver bark, Semen Sterculiae Nobilis, white orchid perfume, Fel Ursi are wooden.The bark (double-layer fur) of Aquifoliaceae Holly Ilex rotunda Thunb., leaf, root also can be used as medicine.Hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flu, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, rheumatic ostalgia; Traumatic injury is controlled in external, carbuncle furuncle infections, traumatic hemorrhage, burn and scald.

Radix Glycyrrhizae: nature and flavor are sweet, flat; Return spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances "." property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 injectable powder of the present invention

Get Rhizoma valerianae latifoliae 14g, Herba Urariae crinitae 19g, Herba Menthae Rotundifoliae 10g, the sub-14g of Lignum cinnamomi camphorae, mountain Herba Eupatorii 27g, Herba Gnaphalii uliginosi 15g, Dasiphora fruticosa (L.) Rydb. 16g, Radix diurantherae majoris 25g, Fructus Dracontomeli Duperreani 17g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12g, Herba Dendrobii 36g, Arisaema intermedium Blume 10g, Radix Helwingiae 11g, Chinese podophyllum root 6g, Herb Polygoni Chinensis 5g, Herba Adianti 22g, Radix Arnebiae (Radix Lithospermi) 35g, Herba speranskiae tuberculatae 5g, Fructus Polygoni Orientalis 34g, Folium Et Cacumen Murrayae 3g, Herba Pyrolae 19g, Herba Peperomiae Dindygulensis 24g, Radix Ranunculi Ternati 23g, Caulis Marsdeniae tinctoriae 15g, Herba Spilanthis Acmellae 8g, Herba Ixeritis Denticulatae 13g, Herba Violae Serpentis 24g, Herba Centellae 22g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 15g, Cortex Ilicis Rotundae 14g and Radix Glycyrrhizae 15g.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrate and after drying, put into super micron mill and pulverize 60 minutes, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 20g that second step obtains, adds propylene glycol 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 granule of the present invention

Get Rhizoma valerianae latifoliae 15g, Herba Urariae crinitae 17g, Herba Menthae Rotundifoliae 16g, the sub-22g of Lignum cinnamomi camphorae, mountain Herba Eupatorii 18g, Herba Gnaphalii uliginosi 12g, Dasiphora fruticosa (L.) Rydb. 18g, Radix diurantherae majoris 20g, Fructus Dracontomeli Duperreani 16g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15g, Herba Dendrobii 31g, Arisaema intermedium Blume 5g, Radix Helwingiae 13g, Chinese podophyllum root 4g, Herb Polygoni Chinensis 8g, Herba Adianti 18g, Radix Arnebiae (Radix Lithospermi) 24g, Herba speranskiae tuberculatae 6g, Fructus Polygoni Orientalis 32g, Folium Et Cacumen Murrayae 6g, Herba Pyrolae 11g, Herba Peperomiae Dindygulensis 25g, Radix Ranunculi Ternati 26g, Caulis Marsdeniae tinctoriae 16g, Herba Spilanthis Acmellae 9g, Herba Ixeritis Denticulatae 18g, Herba Violae Serpentis 14g, Herba Centellae 23g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 16g, Cortex Ilicis Rotundae 23g and Radix Glycyrrhizae 13g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 3 decoction of the present invention

Get Rhizoma valerianae latifoliae 11g, Herba Urariae crinitae 21g, Herba Menthae Rotundifoliae 13g, the sub-18g of Lignum cinnamomi camphorae, mountain Herba Eupatorii 22g, Herba Gnaphalii uliginosi 9g, Dasiphora fruticosa (L.) Rydb. 20g, Radix diurantherae majoris 24g, Fructus Dracontomeli Duperreani 13g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22g, Herba Dendrobii 29g, Arisaema intermedium Blume 8g, Radix Helwingiae 15g, Chinese podophyllum root 7g, Herb Polygoni Chinensis 6g, Herba Adianti 21g, Radix Arnebiae (Radix Lithospermi) 21g, Herba speranskiae tuberculatae 4g, Fructus Polygoni Orientalis 28g, Folium Et Cacumen Murrayae 4g, Herba Pyrolae 14g, Herba Peperomiae Dindygulensis 22g, Radix Ranunculi Ternati 18g, Caulis Marsdeniae tinctoriae 20g, Herba Spilanthis Acmellae 5g, Herba Ixeritis Denticulatae 20g, Herba Violae Serpentis 17g, Herba Centellae 18g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12g, Cortex Ilicis Rotundae 18g and Radix Glycyrrhizae 16g.

Its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 4cm, soak 5 hours;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 5 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 2 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 28.7g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50 of the present invention > 28.7g crude drug/kg, every day, maximum dosage-feeding was 57.4g crude drug/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.

Long term toxicity test: the injectable powder of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Long term toxicity test: the decoction of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Case selection: select patient 164 example meeting Occupational chronic lead poisoning diagnostic criteria incoordination between the spleen and stomach type, wherein man 160 example, female 4 example.33 ~ 60 years old age, average 41 years old.Be divided into four groups at random, between four groups, age, the course of disease etc. are without difference, have comparability:

Injectable powder treatment group: 41 people, male 40 people, female 1 people.

Granules in Treating group: 41 people, male 40 people, female 1 people.

Decoction treatment group: 41 people, male 40 people, female 1 people.

Matched group: 41 people, male 40 people, female 1 people.

Diagnostic criteria:

Carry out diagnosing and classification according to " diagnostic criteria in occupational chronic lead poisoning " GBZ37-2002.

1, calomel poisoning

Blood lead >=2.9 μm ol/L (0.6mg/L, 600 μ g/L) or lead in urine >=0.58 μm ol/L (0.12mg/L, 120 μ g/L); And there is a following shower, diagnosable is calomel poisoning:

A) 6-amino-r-ketoglutaric >=61.0 μm ol/L (8mg/L, 8000 μ g/L) is urinated;

B) erythrocyte dissociates protoporphyrin (EP) >=3.56 μm ol/L (2mg/L, 2000 μ g/L);

C) he matocrit (ZPP) >=2.91 μm ol/L (13.0 μ g/gHb).

D) symptom such as abdominal part dull pain, abdominal distention, constipation is had.

Diagnostic drives lead test, and lead in urine >=3.86 μm ol/L (0.8mg/L, 800 μ g/L) or 4.82 μm of ol/24h (1mg/24h, 1000 μ g/24h) persons, diagnosable is slight lead poisoning.

2, moderate intoxication

On the basis of calomel poisoning, there is a following shower:

A) angina abdominis;

B) anemia;

C) calomel poisoning peripheral neuropathy.

3, severe intoxication

There is a following shower:

A) plumbous paralysis;

B) toxic encephalopthy;

Incoordination between the spleen and stomach type diagnostic criteria: distension and fullness in the abdomen, belch, singultus, poor appetite, pale tongue with white fur band are greasy, stringy and hesitant pulse.

Therapeutic Method:

Injectable powder treatment group: use injectable powder prepared by the embodiment of the present invention 1, once-a-day, 60mg/kg, intravenous drip.Before use, first fully dissolving with appropriate water for injection, then dilute with normal saline or 5% glucose injection 500ml, 7 days is a course for the treatment of.

Granules in Treating group: take granule prepared by the embodiment of the present invention 2, three times on the one, one time 2 bag 7 days is a course for the treatment of.

Decoction treatment group: take decoction prepared by the embodiment of the present invention 3, potion on the one, sooner or later taking for twice, 7 days is a course for the treatment of.

Matched group: add 5% Glucose Liquid 500ml intravenous drip with calcium disodium chelate (CaNa2-EDTA) 1.0g, 1 time/d, be used in conjunction 3d, stopping 4d is 1 course of therapy.

As after 5 courses for the treatment of, PbB or PbU still reaches object of observation diagnostic criteria, then check after 3 months, again drive plumbous treatment if desired.

Outcome measure:

Cure: clinical symptoms, Signs disappear, blood lead, lead in urine recover normal, and other lab testings are normal.

Take a turn for the better: clinical symptoms, Signs disappear substantially, and blood lead, lead in urine inspection and other lab testings are clearly better.

Do not heal: clinical symptoms, Signs are unchanged, blood lead, lead in urine inspection and other lab testings are unchanged.

Therapeutic outcome:

See table 1-3, as can be seen from Table 1 and Table 2, adopt Drug therapy incoordination between the spleen and stomach type occupational chronic lead poisoning of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 3, adopt Drug therapy incoordination between the spleen and stomach type occupational chronic lead poisoning of the present invention, relative to Western medicine, treatment time significantly shortens.

After table 1 Four composition did not treat for 1 course for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Take a turn for the better	Do not heal	Total effective rate
						Injectable powder treatment group	41	9	32	0	100％
Granules in Treating group	41	12	29	0	100％
						Decoction treatment group	41	10	31	0	100％
Matched group	41	5	27	9	78.0％

After table 2 Four composition did not treat for 2 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Take a turn for the better	Do not heal	Total effective rate
						Injectable powder treatment group	41	37	4	0	100％

Granules in Treating group	41	36	5	0	100％
						Decoction treatment group	41	34	7	0	100％
Matched group	41	24	9	8	80.5％

Four groups, table 3 is cured the case time used and is compared

Group	Number of cases	Average cure time sky
			Injectable powder treatment group	37	8±2
Granules in Treating group	36	10±3
			Decoction treatment group	34	11±4
Matched group	24	13±5

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Model case: grandson, storage battery factory workman, man 44 years old, recent sensation distension and fullness in the abdomen, belch, singultus, poor appetite, pale tongue with white fur band are greasy, stringy and hesitant pulse, doubtful occupational chronic lead poisoning, occupational chronic lead poisoning is diagnosed as, Chinese medical discrimination incoordination between the spleen and stomach type through checking after being in hospital.The injectable powder of the embodiment of the present invention 1 is given after making a definite diagnosis, once-a-day, 60mg/kg, intravenous drip.Before use, first fully dissolve with appropriate water for injection, then dilute with normal saline or 5% glucose injection 500ml, check after 3 days that blood lead, lead in urine recover normal, other lab testings are normally cured.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of incoordination between the spleen and stomach type occupational chronic lead poisoning, it is characterized in that, comprise following raw medicinal material: Rhizoma valerianae latifoliae, Herba Urariae crinitae, Herba Menthae Rotundifoliae, Lignum cinnamomi camphorae, mountain Herba Eupatorii, Herba Gnaphalii uliginosi, Dasiphora fruticosa (L.) Rydb., Radix diurantherae majoris, Fructus Dracontomeli Duperreani, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba Dendrobii, Arisaema intermedium Blume, Radix Helwingiae, Chinese podophyllum root, Herb Polygoni Chinensis, Herba Adianti, Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Fructus Polygoni Orientalis, Folium Et Cacumen Murrayae, Herba Pyrolae, Herba Peperomiae Dindygulensis, Radix Ranunculi Ternati, Caulis Marsdeniae tinctoriae, Herba Spilanthis Acmellae, Herba Ixeritis Denticulatae, Herba Violae Serpentis, Herba Centellae, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Cortex Ilicis Rotundae and Radix Glycyrrhizae.

2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 10-16 part, Herba Urariae crinitae 15-23 part, Herba Menthae Rotundifoliae 9-18 part, the sub-12-24 part of Lignum cinnamomi camphorae, mountain Herba Eupatorii 17-29 part, Herba Gnaphalii uliginosi 8-17 part, Dasiphora fruticosa (L.) Rydb. 14-22 part, Radix diurantherae majoris 19-27 part, Fructus Dracontomeli Duperreani 12-18 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-25 part, Herba Dendrobii 28-38 part, Arisaema intermedium Blume 4-11 part, Radix Helwingiae 10-17 part, Chinese podophyllum root 3-8 part, Herb Polygoni Chinensis 4-9 part, Herba Adianti 16-24 part, Radix Arnebiae (Radix Lithospermi) 20-38 part, Herba speranskiae tuberculatae 3-7 part, Fructus Polygoni Orientalis 26-36 part, Folium Et Cacumen Murrayae 2-7 part, Herba Pyrolae 10-20 part, Herba Peperomiae Dindygulensis 21-26 part, Radix Ranunculi Ternati 16-30 part, Caulis Marsdeniae tinctoriae 13-23 part, Herba Spilanthis Acmellae 4-10 part, Herba Ixeritis Denticulatae 12-22 part, Herba Violae Serpentis 13-27 part, Herba Centellae 16-25 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 10-18 part, Cortex Ilicis Rotundae 12-25 part and Radix Glycyrrhizae 12-17 part.

3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 11-15 part, Herba Urariae crinitae 17-21 part, Herba Menthae Rotundifoliae 10-16 part, the sub-14-22 part of Lignum cinnamomi camphorae, mountain Herba Eupatorii 18-27 part, Herba Gnaphalii uliginosi 9-15 part, Dasiphora fruticosa (L.) Rydb. 16-20 part, Radix diurantherae majoris 20-25 part, Fructus Dracontomeli Duperreani 13-17 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12-22 part, Herba Dendrobii 29-36 part, Arisaema intermedium Blume 5-10 part, Radix Helwingiae 11-15 part, Chinese podophyllum root 4-7 part, Herb Polygoni Chinensis 5-8 part, Herba Adianti 18-22 part, Radix Arnebiae (Radix Lithospermi) 21-35 part, Herba speranskiae tuberculatae 4-6 part, Fructus Polygoni Orientalis 28-34 part, Folium Et Cacumen Murrayae 3-6 part, Herba Pyrolae 11-19 part, Herba Peperomiae Dindygulensis 22-25 part, Radix Ranunculi Ternati 18-26 part, Caulis Marsdeniae tinctoriae 15-20 part, Herba Spilanthis Acmellae 5-9 part, Herba Ixeritis Denticulatae 13-20 part, Herba Violae Serpentis 14-24 part, Herba Centellae 18-23 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12-16 part, Cortex Ilicis Rotundae 14-23 part and Radix Glycyrrhizae 13-16 part.

4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 14 parts, Herba Urariae crinitae 19 parts, Herba Menthae Rotundifoliae 10 parts, Lignum cinnamomi camphorae 14 parts, mountain Herba Eupatorii 27 parts, Herba Gnaphalii uliginosi 15 parts, Dasiphora fruticosa (L.) Rydb. 16 parts, Radix diurantherae majoris 25 parts, Fructus Dracontomeli Duperreani 17 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12 parts, Herba Dendrobii 36 parts, Arisaema intermedium Blume 10 parts, 11 parts, Radix Helwingiae, Chinese podophyllum root 6 parts, Herb Polygoni Chinensis 5 parts, Herba Adianti 22 parts, Radix Arnebiae (Radix Lithospermi) 35 parts, Herba speranskiae tuberculatae 5 parts, Fructus Polygoni Orientalis 34 parts, Folium Et Cacumen Murrayae 3 parts, Herba Pyrolae 19 parts, Herba Peperomiae Dindygulensis 24 parts, Radix Ranunculi Ternati 23 parts, Caulis Marsdeniae tinctoriae 15 parts, Herba Spilanthis Acmellae 8 parts, Herba Ixeritis Denticulatae 13 parts, Herba Violae Serpentis 24 parts, Herba Centellae 22 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 15 parts, Cortex Ilicis Rotundae 14 parts and 15 parts, Radix Glycyrrhizae.

5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 15 parts, Herba Urariae crinitae 17 parts, Herba Menthae Rotundifoliae 16 parts, Lignum cinnamomi camphorae 22 parts, mountain Herba Eupatorii 18 parts, Herba Gnaphalii uliginosi 12 parts, Dasiphora fruticosa (L.) Rydb. 18 parts, Radix diurantherae majoris 20 parts, Fructus Dracontomeli Duperreani 16 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 parts, Herba Dendrobii 31 parts, Arisaema intermedium Blume 5 parts, 13 parts, Radix Helwingiae, Chinese podophyllum root 4 parts, Herb Polygoni Chinensis 8 parts, Herba Adianti 18 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, Herba speranskiae tuberculatae 6 parts, Fructus Polygoni Orientalis 32 parts, Folium Et Cacumen Murrayae 6 parts, Herba Pyrolae 11 parts, Herba Peperomiae Dindygulensis 25 parts, Radix Ranunculi Ternati 26 parts, Caulis Marsdeniae tinctoriae 16 parts, Herba Spilanthis Acmellae 9 parts, Herba Ixeritis Denticulatae 18 parts, Herba Violae Serpentis 14 parts, Herba Centellae 23 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 16 parts, Cortex Ilicis Rotundae 23 parts and 13 parts, Radix Glycyrrhizae.

6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma valerianae latifoliae 11 parts, Herba Urariae crinitae 21 parts, Herba Menthae Rotundifoliae 13 parts, Lignum cinnamomi camphorae 18 parts, mountain Herba Eupatorii 22 parts, Herba Gnaphalii uliginosi 9 parts, Dasiphora fruticosa (L.) Rydb. 20 parts, Radix diurantherae majoris 24 parts, Fructus Dracontomeli Duperreani 13 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22 parts, Herba Dendrobii 29 parts, Arisaema intermedium Blume 8 parts, 15 parts, Radix Helwingiae, Chinese podophyllum root 7 parts, Herb Polygoni Chinensis 6 parts, Herba Adianti 21 parts, Radix Arnebiae (Radix Lithospermi) 21 parts, Herba speranskiae tuberculatae 4 parts, Fructus Polygoni Orientalis 28 parts, Folium Et Cacumen Murrayae 4 parts, Herba Pyrolae 14 parts, Herba Peperomiae Dindygulensis 22 parts, Radix Ranunculi Ternati 18 parts, Caulis Marsdeniae tinctoriae 20 parts, Herba Spilanthis Acmellae 5 parts, Herba Ixeritis Denticulatae 20 parts, Herba Violae Serpentis 17 parts, Herba Centellae 18 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12 parts, Cortex Ilicis Rotundae 18 parts and 16 parts, Radix Glycyrrhizae.

7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrate and after drying, put into super micron mill and pulverize 40 ~ 60 minutes, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.