CN106389552A - Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage - Google Patents

Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage Download PDF

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CN106389552A
CN106389552A CN201510967829.3A CN201510967829A CN106389552A CN 106389552 A CN106389552 A CN 106389552A CN 201510967829 A CN201510967829 A CN 201510967829A CN 106389552 A CN106389552 A CN 106389552A
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chinese medicinal
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王丽娟
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

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Abstract

The invention relates to a traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage. The traditional Chinese medicinal ointment is characterized by being prepared from the following traditional Chinese medicinal raw materials in parts by weight: 6-9 parts of coriolus versicolor, 4-6 parts of ferrosic oxide, 6-8 parts of concha arcae, 6-8 parts of zaocys dhumnade, 4-6 parts of rhizoma cimicifugae, 6-8 parts of fructus podophylli, 4-6 parts of rhizoma anemones altaicae and 4-6 parts of liquorice root. The traditional Chinese medicinal ointment has the beneficial effects that the traditional Chinese medicinal ointment is capable of strengthening body resistance and eliminating pathogenic factors, opening orifices, dispelling wind, removing stasis and dredging collaterals, and the traditional Chinese medicinal ointment conforms to the treatment principle of repairing damaged brain tissue; and the traditional Chinese medicine provided by the invention is rapid to take a curative effect, high in cure rate and free from toxic and side effects.

Description

One kind treats viral encephalitis with encephaloclastic Chinese medicinal ointment
Technical field
The present invention relates to one kind treats viral encephalitis with encephaloclastic Chinese medicinal ointment.
Background technology
It is known that viral encephalitis is virus through enteron aisle (as enterovirus) or respiratory tract (as adenovirus and Rash diease) Enter lymphatic system breeding, then through the outer some internal organs of blood flow (arboviruse is directly entered blood flow) infection cranium, now patient can have The constitutional symptoms such as heating.Morbidity is anxious, rapid onset.Clinical nervous system damage symptom is more rare, once in a while find stravismus, diplopia, Sensory disturbance, incoordination, tendon reflex is asymmetric and pathologic reflex is positive.Severe one may occur in which the disease of the nervous system damages such as lethargic sleep , comparatively fast tonic neck in shape and typical meningeal irritation sign such as Kernig levies the positive.Severe one may occur in which that the nervous systems such as lethargic sleep are damaged The symptom of evil.The traditional Chinese medical science thinks based on genus " heat, phlegm, wind, frightened ".Conventional ACV (acyclovir) and symptomatic treatment treatment. Antiviral therapy and symptomatic treatment at present.Cure the symptoms, not the disease, bring body and mind not enough to patient.
Content of the invention
Treatment by Chinese herbs beneficial effect of the present invention is:Strengthening vital QI to eliminate pathogenic factors, have one's ideas straightened out, wind-dispelling, stagnation resolvation, dredging collateral, repair impaired brain group It is woven to the rules for the treatment of, the preparation of this medicine is simple, low cost, curative effect are fast, and cure rate is high, has no toxic side effect, clinic is often according to different card types Diagnosis and treatment based on an overall analysis of the illness and the patient's condition.
For achieving the above object, a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that the bulk drug number of Chinese medicine As follows:6~9 parts of rainbow conk, the pig iron fall 4~6 parts, 6~8 parts of blood clam, 6~8 parts of zaocys dhumnade, 4~6 parts of rattletop, leaflet 6~8 parts of lotus, 4~6 parts of acorus graminens soland, 4~6 parts of Radix Glycyrrhizae.
Prepared by technique:Zaocys dhumnade is ground into fine powder with blood clam after corrugation sub-pieces scalding standby.First by ginseng water extraction 1 hour, Filtrate is standby.Residue and rattletop, Himalayan mayapple fruit, acorus graminens soland, Radix Glycyrrhizae are put in Multifunctional Chinese medicine extractor, with 10 times, concentration For 65% alcohol extract 2 hours, extract 3 times, filter, merge extract and reclaim ethanol to the greatest extent;On extract, D101 type is big Macroporous adsorbent resin post, first with distillation water elution, wash-out distilled water is 12 times of column volume, and eluent discards, then with 65% Ethanol carries out gradient elution, and wash-out ethanol is 8 times of column volume, and eluent reclaims ethanol to the greatest extent, obtains leachate, denseer Contract, be dried, obtain final product.Again by residue:Decocting three times, by 3: 2: 1 hours, filters after decocting, takes filtrate standby.Will be above-mentioned standby Medication powder, alcohol extract, Aqueous extracts merge, and stir evenly, plus paste made by dextrin, obtains final product.
In the present invention, rainbow conk belongs to immunomodulator containing coriolan, strengthens immunity of organisms, is good immunopotentiator, tool There are enhancing immune cell function and recognition capability, improve the amount of IgM.The pig iron falls to having relieving convulsion.For demented, easily frightened kind anger, Insomnia.Blood clam taste is salty, mild-natured.Return lung, stomach, Liver Channel.Dissolving phlegm stagnation resolvation, softening and resolving hard mass, relieving haperacidity pain relieving.For stupid phlegm glue Knot, sticky difficulty is coughed up, goiter and tumor, scrofula, lump in the abdomen lump in the abdomen, pantothenic acid of having a stomachache.Himalayan mayapple fruit bitter, micro-pungent, warm in nature.Return liver and kidney channel. Promoting blood circulation for regulating menstruation, dispelling wind and eliminating dampness.For blood stasis is through closing, traumatic injury, arthralgia due to wind-dampness.Zaocys dhumnade belongs to the bodily form for Colubridae zaocys dhumnade Larger snake.Medicinal material is the hirudo leech of Colubridae animal zaocys dhumnade.Zaocys dhumnade is cut open the belly or first peels off snakeskin to let the hair grow tail, remove in Dirty, it is coiled into the shape of a disc, drying forms, and gathers and processes in summer, Qiu Liangji more.Zaocys dhumnade is mild-natured, sweet, has wind-dispelling, dredging collateral, stops Effect of convulsion, can treat rheumatoid arthritis stubborn, numbness contracture, the middle air port eye illness such as tiltedly.Acorus graminens soland taste is pungent, warm in nature.The thoughts of returning home, Stomach.Function with cure mainly:Reducing phlegm by resuscitation, activating spleen and easing mental stress.For pyreticosis coma, epilepsy, Hiccough and deaf, abdominal distension uncomfortable in chest, food It is intended to depressed;Control outward ulcer sore tinea.Radix Glycyrrhizae, is the composition having medical value extracting from Radix Glycyrrhizae.Licorice generally comprises: Glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, formoononetin, Quercetin etc..For yellow extremely Brownish-yellow powder.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.All medicines are joined above 5 this disease for the treatment of, bring out the best in each other.
The present invention follows the prescriptions principle of the traditional Chinese medical science, and the present invention is according to clinical verification:Cure rate be more than 85%, efficient More than 90%, have no toxic side effect.
Specific embodiment
With reference to implementing case, the invention will be further described:
Embodiment 1:One kind treats viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that weighing material medicine by following weight:6~9 parts of rainbow conk, The pig iron fall 4~6 parts, 6~8 parts of blood clam, 6~8 parts of zaocys dhumnade, 4~6 parts of rattletop, 6~8 parts of Himalayan mayapple fruit, 4~6 parts of acorus graminens soland, sweet 4~6 parts of grass.Preparation is ibid.
Embodiment 2;One kind treats viral encephalitis with encephaloclastic Chinese medicine composition it is characterised in that weighing material medicine by following proportionings:9 parts of rainbow conk, The pig iron fall 6 parts, 8 parts of blood clam, 8 parts of zaocys dhumnade, 4 parts of rattletop, 8 parts of Himalayan mayapple fruit, 4 parts of acorus graminens soland, 6 parts of Radix Glycyrrhizae.Preparation is with enforcement Example 1.
Clinical efficacy is summarized:
First, we for many years in clinical practice extensively, treat 68 patients, and curative effect frequency is good.
2nd, diagnostic criteria:Have flu history, onset is acute or subacute, have severe headache, heating, vomiting, neck rigidity, Typical meningeal irritation sign such as Kernig levies the positive, and have general malaise, pharyngalgia, photophobia, dizziness, listless, feel different Often, myalgia, stomachache and shiver with cold etc..Some patientss may occur in which the symptoms such as angina, eye-blurred.Enterovirus infection may occur in which Fash, is mostly occurred with heating simultaneously, continues 4~10 days.COxsackie A5,9,16 virus and ECHO4,6,9,16, 30 virus infection, cerebrospinal pressure increases.
3rd, administrated method:It is decocted in water for oral dose, daily 1 dose of adult, 1/2~1/3 dose of children, all 2 times a day for 1/3 dose of child, Early, late sub-service.1/4 dose of baby, divides and feeds for 3~5 times.
4th, efficacy evaluation:
Cure:Clinical symptoms are wholly absent.
Take a turn for the better:Clinical symptoms are improved.
Do not heal:Clinical symptoms are no improved or are increased.
5th, therapeutic effect:This disease for the treatment of by Chinese herbs of the present invention, through statistics cure rate more than 85%, efficient more than 90%.
6th, model case
1st, Lee XX, female, 38 years old, in October, 2011 went to a doctor, patient main suit:Heating, Nausea and vomiting, larynx before 2 days Bitterly, through giving antiviral agent, antibiotic therapy, effect on driving birds is not good in local hospital.Laboratory examination:Adenovirus can be found.Suffer from Person requires to take 10 doses of Chinese medicine of the present invention, and clinical symptoms are wholly absent, and laboratory examination recovers normal, and half a year follow-up is not recurred again.
2nd, open X, man, 33 years old, goes to a doctor in August, 2013, patient main suit has a headache, nausea, kecks 1 week, through existing After local hospital anodyne, after improvement again repeatedly, effect on driving birds is not good.Have a medical check-up:Meningeal irritation sign, laboratory examination:Find intestines Road virus.The patient head of a family requires to take 10 doses of Chinese medicine of the present invention, 1/2 amount of adult, clinical symptoms are wholly absent, laboratory inspection Look into recovery normal, follow-up after this year is not recurred again.
3rd, king XX, female, 10 years old, go to a doctor in May, 2014, before the head of a family tells 5 days in generation, heating, nausea, meninx pierces Swash and levy the positive, not good with children coryza medicine therapeutic effect, increase companioned with headache, laboratory examination today:Find enterovirus.Suffer from Mother person patient requests take 8 doses of Chinese medicine of the present invention, and with 1/2 amount of adult, clinical symptoms are wholly absent, laboratory examination recovery Normally, after March, follow-up is not recurred again.

Claims (2)

1. a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that bulk drug part of Chinese medicine Number is as follows:A kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that the bulk drug number of Chinese medicine is as follows: 6~9 parts of rainbow conk, the pig iron fall 4~6 parts, 6~8 parts of blood clam, 6~8 parts of zaocys dhumnade, 4~6 parts of rattletop, Himalayan mayapple fruit 6~ 8 parts, 4~6 parts of acorus graminens soland, 4~6 parts of Radix Glycyrrhizae.
2. according to claim 1 a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment technique prepare, It is characterized in that first with blood clam, zaocys dhumnade being ground into fine powder after corrugation sub-pieces scalding standby.First by ginseng water extraction 1 Hour, filtrate is standby.Residue and rattletop, Himalayan mayapple fruit, acorus graminens soland, Radix Glycyrrhizae are put into Multifunctional Chinese medicine and extract In tank, with 10 times, concentration be 65% alcohol extract 2 hours, extract 3 times, filter, merge extract Reclaim ethanol to the greatest extent;D101 type large pore resin absorption column on extract, first with distillation water elution, wash-out steams Distilled water is 12 times of column volume, and eluent discards, then carries out gradient elution, wash-out second with 65% ethanol Alcohol is 8 times of column volume, and eluent reclaims ethanol to the greatest extent, obtains leachate, then concentrates, is dried, and obtains final product. Again by residue:Decocting three times, by 3: 2: 1 hours, filters after decocting, takes filtrate standby.By above-mentioned standby medicinal powder, Alcohol extract, Aqueous extracts merge, and stir evenly, plus paste made by dextrin, obtains final product.
CN201510967829.3A 2015-12-14 2015-12-14 Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage Pending CN106389552A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107137593A (en) * 2017-06-29 2017-09-08 贵州松桃信仁苗药有限公司 It is a kind of to promote Chinese medicinal ointment of wound healing after operation and preparation method thereof

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CN1260201A (en) * 1999-09-10 2000-07-19 张发平 Chinese preparatory medicine and its preparation method
CN102861189A (en) * 2012-09-16 2013-01-09 丛艳彬 Traditional Chinese medicine composition for treating viral encephalitis
CN105051005A (en) * 2012-10-12 2015-11-11 武田药品工业株式会社 Cyclopropanamine compound and use thereof
CN103920042A (en) * 2014-04-23 2014-07-16 王林 Drug for treating heat invasion nutritive blood type virus meningitis, as well as preparation method thereof
CN104095961A (en) * 2014-07-15 2014-10-15 烟台海研制药有限公司 Traditional Chinese medicine combination for treating viral encephalitis of mink
CN104178399A (en) * 2014-08-11 2014-12-03 济南环太机电技术有限公司 Health medical liquor for cephalomeningitis sequela
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107137593A (en) * 2017-06-29 2017-09-08 贵州松桃信仁苗药有限公司 It is a kind of to promote Chinese medicinal ointment of wound healing after operation and preparation method thereof

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