CN104547703A - Traditional Chinese medicine composition for treating infantile eczema and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating infantile eczema and preparation method of traditional Chinese medicine composition Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention aims at overcoming the shortages of the prior art, and providing a traditional Chinese medicine composition for treating infantile eczema and a preparation method of the traditional Chinese medicine composition. The medicine provided by the invention meets the principle of traditional Chinese medicine compatibility, is designed from a fundament, and is used for completely eliminating hot gas and dehumidifying through the compatibility of ailanthus leaves, mint leaves, aloe leaves, evodia lepta merr leaves and stenoloma chusana leaves, and fundamentally treating eczema, and killing and eliminating fungi below epidermis of the skin by virtue of stinkgrass flower, lantern plant calyx, litchi leaves, ipomoea pes-caprae roots, babylon weeping willow flower, scandent hop, hairy flower wasp larva and arborvitae root bark, thus alleviating and eliminating the eczema phenomenon, and then enabling an infant to achieve a rehabilitation purpose; cucumber and lemon are juiced for blending said medicines to improve the moisturizing effect and protect the skin, and also play a treatment role, and the dryness and tension of the skin are reduced during a use process, and moreover, the medicine is low in irritation, is easily accepted by infants, and is wide in application prospect.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of Chinese medicine composition for the treatment of infantile eczema and preparation method thereof.
Background technology
Infantile eczema is a kind of allergic skin disease, is exactly the anaphylaxis dermatosis usually said.Main cause not to tolerate ingestant, inhalation (inhalatio) or contactant or caused by allergy.The child suffering from eczema originally skin rubefaction, occur that erythra, then skin are sent out rough, desquamation, stroke the skin of child as touch is on sand paper.The wet eczema that all can make of heat, chance shows significantly.
Cause the cause of disease of eczema to be complicated, wherein most importantly intolerance factors is, so there is the children's of allergic constitution family history more easily eczema to occur.Main cause is not for tolerate ingestant, inhalation (inhalatio) or contactant or caused by allergy.
The infringement of eczema onset, for papulovesicle or vesicle appear intensive foxtail millet grain size pimple, in erythema basis, forms rotten to the corn face after vesicle is broken, has serosity to ooze out, incrustation.Acute eczema is dealt with improperly, can transfer subacute or chronic eczema to, can take a turn for the better gradually, but easily recur as suitably treated in time.Can be there is large stretch of erythema in severe one, it is pimple, papulovesicle, vesicle, rotten to the corn sepage in groups, there is thick crust on surface, also can prolong and whole Head And Face or incidence.There is erythematous papules, papulovesicle, vesicle, conscious pruritus in perilesional.Can be there is erosion, incrustation in galling, have pus to ooze out under crust, there is pimple at edge, regional glandular enlargement, tenderness.Neighbouring or remote part also can have parallel line shaped erythema, pimple and the vesicle of scratching caused.
Diagnosis: have diseases caused by exogenous pathogenic factor or unhygienic diet medical history.Skin lesion is pleomorphism, and erythema, pimple, vesicle (not forming bulla), erosion, sepage, incrustation etc. mix appearance.How because of outbreaks such as edible fish, shrimp, Eriocheir sinensis, Carnis caprae seu ovis, coffee, wine, marors or increase the weight of.Skin lesion mostly is limitation, and boundary is clear, and in kermesinus or taupe, above cover squama, surface skin is coarse, plump, and sulci of skin is obvious, in lichenification, or inflammation sheet block of chapping in hyperkeratosis.Lab testing changes without specificity, and blood eosinophils may increase.Skin patch test has certain limitation.
But the medicine for the treatment of infantile eczema is a feast for the eyes at present, therapeutic effect is also all general, take effect slow, some chemical composition contains hormone medicine, inapplicable to pediatric patient, therefore also to need to study a kind of therapeutic effect remarkable in market, instant effect, have no side effect, what non-stimulated a kind of applicable pediatric patient was suitable for specially controls eczema medicine.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and a kind of Chinese medicine composition for the treatment of infantile eczema and preparation method thereof is provided, medicine of the present invention meets the principle of drug matching, first fundamentally start with, pass through Folium ailanthi, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis compatibility removes steam completely, dehumidifying, from treating eczema at all, again with Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., Cortex Biotae Radicis kills and eliminates the fungus below epiderm skin, eczema phenomenon is made to be eased and to eliminate, thus make baby reach the object of rehabilitation, and use Fructus Cucumidis sativi, lemon juicing is in harmonious proportion above medicine increases its moistening effect, protection skin, also there is therapeutical effect simultaneously, the drying of skin is decreased in use procedure, tension, and zest is little, infant is easy to accept, therefore have a extensive future.
Treating a Chinese medicine composition for infantile eczema, is that the raw material of joining part by following weight is made:
Folium ailanthi 10-20 part, mentha leave 20-30 part, Folium Aloe 20-30 part, Foliumet Ramulus Evodiae 20-30 part, Folium Stenolomatis 10-20 part, Flos Eragrostinis cilianensis 10-20 part, Calyx seu Fructus physalis 10-20 part, Folium Litchi 20-30 part, Ipomoea pescaprae(L.) Sweet 1.0-10 part, Flos Salicis Babylonicae 1.0-10 part, Herba humuli scandentis 1.0-10 part, Discolia vittifrons Sch. 0.1-5.0 part, Cortex Biotae Radicis 1.0-10 part, Fructus Cucumidis sativi 20-30 part, Fructus Citri Limoniae 20-30 part;
Invention formulation is that the preparation method of unguentum is as follows:
Folium ailanthi is got by formula proportion, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., Cortex Biotae Radicis, Fructus Cucumidis sativi, Fructus Citri Limoniae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stir after leaving standstill, again through cold preservation, flatten, sterilization packaging technology.
Treating a Chinese medicine composition for infantile eczema, is that the raw material of joining part by following weight is made:
Folium ailanthi 12-18 part, mentha leave 22-28 part, Folium Aloe 22-28 part, Foliumet Ramulus Evodiae 22-28 part, Folium Stenolomatis 12-18 part, Flos Eragrostinis cilianensis 12-18 part, Calyx seu Fructus physalis 12-18 part, Folium Litchi 22-28 part, Ipomoea pescaprae(L.) Sweet 2.0-8.0 part, Flos Salicis Babylonicae 2.0-8.0 part, Herba humuli scandentis 2.0-8.0 part, Discolia vittifrons Sch. 1.0-4.0 part, Cortex Biotae Radicis 2.0-8.0 part, Fructus Cucumidis sativi 22-28 part, Fructus Citri Limoniae 22-28 part;
Invention formulation is that the preparation method of abrasive cleaner is as follows:
1) by formula proportion, Fructus Cucumidis sativi, Fructus Citri Limoniae are added water and distill, collect distillate 200ml for subsequent use;
2) by formula proportion by Folium ailanthi, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., the Cortex Biotae Radicis removal of impurity, remove putrefaction, after soaking 30 minutes, add the water of quintuple, slow fire boiling 2 hours, boil and carry twice, get supernatant for subsequent use;
3) by method 2) supernatant and method 1) the 200ml distillate collected is combined, dilution regulates pH value, and subpackage, sterilizing, namely obtains Traditional Chinese medicinal abrasive cleaner of the present invention.
Treating a Chinese medicine composition for infantile eczema, is that the raw material of joining part by following weight is made:
Folium ailanthi 15 parts, mentha leave 25 parts, Folium Aloe 25 parts, Foliumet Ramulus Evodiae 25 parts, Folium Stenolomatis 15 parts, Flos Eragrostinis cilianensis 15 parts, Calyx seu Fructus physalis 15 parts, Folium Litchi 25 parts, Ipomoea pescaprae(L.) Sweet 5.0 parts, Flos Salicis Babylonicae 5.0 parts, Herba humuli scandentis 5.0 parts, Discolia vittifrons Sch. 2.5 parts, Cortex Biotae Radicis 5.0 parts, Fructus Cucumidis sativi 25 parts, 25 parts, Fructus Citri Limoniae.
the property of medicine and the pharmacology of medicine selected by the present invention are respectively:
Fructus Cucumidis sativi:
Nature and flavor: sweet in the mouth; Cool in nature.
Gui Jing: return lung; Spleen; Stomach warp.
Function cures mainly: heat clearing away; Diuretic; Removing toxic substances.Main calentura is thirsty; Oliguria with reddish urine; Edema oliguria; Burn due to hot liquid or fire; Tinea versicolor; Non-skin ulcer.
Fructus Citri Limoniae:
[meridian distribution of property and flavor] sour in the mouth is sweet, property is flat, enters liver, stomach warp.
[function] has preventing phlegm from forming and stopping coughing, promotes the production of body fluid, effect of spleen invigorating; Mainly treating bronchitis, pertussis, vitamin C deficiency, heatstroke excessive thirst, inappetence, pregnant woman's disorder of stomach-QI, poor appetite, eructation etc.
Flos Eragrostinis cilianensis:
Herb: wind and heat dispersing, diuresis; Inflorescence: removing toxic substances, antipruritic.
Calyx seu Fructus physalis:
Nature and flavor
Acid, cold.
1. " not Lu ": cold.
2. " ancient wine vessel speech ": acid is sweet.
3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": slightly warm in nature, salty in the mouth.
4. " detailed outline ": acid, flat, nontoxic.
Gui Jing
1. " Shaanxi Chinese medicinal herbal ": enter liver, spleen two warp.
2. " east, Fujian book on Chinese herbal medicine ": enter lung, spleen two warp.
Effect
Heat clearing away, removing toxic substances, diuresis.
Control hectic fever due to YIN-deficiency consumptive fever, cough, laryngopharynx swelling and pain, jaundice, edema, sky bubble eczema.
Folium Litchi:
[nature and flavor] are pungent; Bitter; Cool
[return through] heart channel
[function cures mainly] removing dampness and detoxicating.Main rotten skin ulcer; Eczema
Ipomoea pescaprae(L.) Sweet:
Cure mainly the effects such as acute toothache, articular rheumatic pain, erysipelas, eczema.
Flos Salicis Babylonicae:
[nature and flavor] are bitter, cold.
1. " herbal classic ": bitter in the mouth, cold.
2. " not Lu ": nontoxic.
3. " this sketch of the southern regions of the Yunnan Province is said ": sweet-bitter flavor is light, flat.
[function cures mainly] dispels the wind, dampness removing, hemostasis, dissipating blood stasis.Control edema due to wind pathogen, jaundice, hemoptysis, spit blood, have blood in stool, stranguria with blood, women's amenorrhea, toothache.
Herba humuli scandentis:
[source]: the herb of Cannabaceae humulus plants Herba humuli scandentis Humulus scandens (Lour.) Merr..Xia Qiu gathers, and cutting is dried.
[method for making]: clean, dry, chopping is used.
[meridian distribution of property and flavor]: sweet, bitter, cold.
[function cures mainly]: heat-clearing and toxic substances removing, inducing diuresis to remove edema.For pulmonary tuberculosis hectic fever, gastroenteritis, dysentery, cold, fever, dysuria, pyelonephritis, acute nephritis, cystitis, urinary system calculus; Carbuncle furuncle and phyma poison is controlled in external, eczema, venom.
Discolia vittifrons Sch.:
[nature and flavor] are sweet.Cool.
[function cures mainly] controls carbuncle kind, erysipelas, rubella.
1. " herbal classic ": main carbuncle.
2. " not Lu ": main pharyngalgia.
3. " something lost lifted by book on Chinese herbal medicine ": main erysipelas, rubella, abdomen Nei Liure, defecation is puckery, removes floating blood, married woman's leukorrhagia, lower milk.
Cortex Biotae Radicis:
[nature and flavor] are pained, cool.
1. Tang Materia Medica: bitter in the mouth is poisonous.
2. " Bencao Jingshu ": bitter, be slightly cold.
3. " herbal classic is met former ": sweet, flat, nontoxic.
4. " medical center bun is wanted ": bitter sweet puckery, cold.
" detailed outline "; Hardship, flat, nontoxic.
[function cures mainly] controls chronic diarrhea, chronic dysentery, discharging fresh blood stool, and bleeding not during menses sends essence, nebulousurine, infantile malnutrition, ascarid, skin ulcer numbness." classifying herbal ": control the inferior blood, spit blood; Deliver cold expelling, attack children's's varioliform exanthema." Chinese herbal medicine is commonly used in Sichuan ": can deliver, saturating measles.
Folium ailanthi (chu):
[return through] lung meridian
[effect]: heat clearing and damp drying; Parasite killing
[textual criticism]: come from Compendium of Material Medica section and belong to classification: Simarubaceae
[curing mainly]: damp and hot dysentery; Have loose bowels; Dysentery; Eczema; Skin ulcer scabies; Furuncle and phyma.
Mentha leave:
[meridian distribution of property and flavor] is cool in nature, acrid in the mouth;
The effect of [function] irritation causes trachea to produce new secretion, and makes the mucus of stiff be easy to get rid of, therefore has the effect of eliminating the phlegm, sterilizing.
It is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.Place uses can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Herba Menthae of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.Steam face with mint tea mist, also have the effect of shrinking pore.Apply by the blade steeping tea and can feel refrigerant on eyes, can eyestrain be removed.It is said and can be used for the another name that Herba Menthae also has " eyes grass " treating ophthalmic.
Folium Aloe: the Pharmacopoeia of the People's Republic of China (version one in 2000) say in this way nature and flavor with return through: bitter, cold; Return liver, stomach, large intestine channel; Function with cure mainly: removing heat from the liver, relieving constipation; For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.Compendium of Material Medica says nature and flavor in this way: bitter, cold, nontoxic; Cure mainly: hot blast is unhappy, steam between septum pectorale, improving eyesight relieving palpitation, children epilepsy infantile convulsion, treat five kinds of child malnutrition, kill three worms and the sick skin ulcer fistula of hemorrhoid, separate Fructus Crotonis poison."The Chinese material medica, concentrated herbal medicine of the Chinese material medica will aloe health care function summarized as: (1) drainage, namely runchang purge;Diction of adjusting human body's immunity;(3) resistance to swelling nodule;(4) to protect the liver;5] stomach damage resistance;[6] antibacterial;Once the repair tissue damage;Being supplied to the protection of the skin.Hardship, cold.Return liver, stomach, large intestine channel.Functions and indications: drainage, namely runchang purge;Adjust immunity;Resistance to swelling nodule;To protect the liver;Gastric damage resistance;Antibacterial;Repair tissue damage;The protection of the skin.
Foliumet Ramulus Evodiae:
[function cures mainly] heat clearing away, removing toxic substances, dispels the wind, dehumidifying.Control laryngopharynx swelling and pain, malaria, icterohepatitis, rheumatic ostalgia, eczema, dermatitis, skin infection.
Folium Stenolomatis:
[nature and flavor]: " Guangxi Chinese medicinal herbal ": micro-hardship, cold, nontoxic.
[function cures mainly]: effect of Folium Stenolomatis, heat clearing away, removing toxic substances, dampness removing, hemostasis.Control anemopyretic cold, heatstroke sun stroke, has loose bowels, dysentery, nebulousurine, leucorrhea, cough, spits blood, has blood in stool, hematuria, ulcerative gingivitis, carbuncle.
Guangzhou army " conventional Chinese herbal medicine handbook ": herb: heat clearing away, removing toxic substances, dampness removing.Control influenza, flu, cough, tonsillitis, parotitis, enteritis, dysentery, skin eczema.
detailed description of the invention:
embodiment 1, formula:
Folium ailanthi 10mg, mentha leave 20mg, Folium Aloe 20mg, Foliumet Ramulus Evodiae 20mg, Folium Stenolomatis 10mg, Flos Eragrostinis cilianensis 10mg, Calyx seu Fructus physalis 10mg, Folium Litchi 20mg, Ipomoea pescaprae(L.) Sweet 1.0mg, Flos Salicis Babylonicae 1.0mg, Herba humuli scandentis 1.0mg, Discolia vittifrons Sch. 0.1mg, Cortex Biotae Radicis 1.0mg, Fructus Cucumidis sativi 20mg, Fructus Citri Limoniae 20mg;
Invention formulation is that the preparation method of unguentum is as follows:
Folium ailanthi is got by formula proportion, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., Cortex Biotae Radicis, Fructus Cucumidis sativi, Fructus Citri Limoniae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stir after leaving standstill, again through cold preservation, flatten, sterilization packaging technology.
animal local excitation is tested:
The allergic reaction on guinea pigs of suppository of the present invention.Result shows: skin anaphylactic test, high dose group 0.8g (medicine)/kg, low dose group 0.1g (medicine)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicine)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicine)/kg, low dose group 3.2g (medicine)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
embodiment 2, formula:
Folium ailanthi 12mg, mentha leave 22mg, Folium Aloe 22mg, Foliumet Ramulus Evodiae 22mg, Folium Stenolomatis 12mg, Flos Eragrostinis cilianensis 12mg, Calyx seu Fructus physalis 12mg, Folium Litchi 22mg, Ipomoea pescaprae(L.) Sweet 2.0mg, Flos Salicis Babylonicae 2.0mg, Herba humuli scandentis 2.0mg, Discolia vittifrons Sch. 1.0mg, Cortex Biotae Radicis 2.0mg, Fructus Cucumidis sativi 22mg, Fructus Citri Limoniae 22mg;
Invention formulation is that the preparation method of abrasive cleaner is as follows:
1) by formula proportion, Fructus Cucumidis sativi, Fructus Citri Limoniae are added water and distill, collect distillate 200ml for subsequent use;
2) by formula proportion by Folium ailanthi, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., the Cortex Biotae Radicis removal of impurity, remove putrefaction, after soaking 30 minutes, add the water of quintuple, slow fire boiling 2 hours, boil and carry twice, get supernatant for subsequent use;
3) by method 2) supernatant and method 1) the 200ml distillate collected is combined, dilution regulates pH value, and subpackage, sterilizing, namely obtains Traditional Chinese medicinal abrasive cleaner of the present invention.
embodiment 3, formula:
Folium ailanthi 15mg, mentha leave 25mg, Folium Aloe 25mg, Foliumet Ramulus Evodiae 25mg, Folium Stenolomatis 15mg, Flos Eragrostinis cilianensis 15mg, Calyx seu Fructus physalis 15mg, Folium Litchi 25mg, Ipomoea pescaprae(L.) Sweet 5.0mg, Flos Salicis Babylonicae 5.0mg, Herba humuli scandentis 5.0mg, Discolia vittifrons Sch. 2.5mg, Cortex Biotae Radicis 5.0mg, Fructus Cucumidis sativi 25mg, Fructus Citri Limoniae 25mg;
Preparation method is identical with embodiment 1.
embodiment 4, formula:
Folium ailanthi 18mg, mentha leave 28mg, Folium Aloe 28mg, Foliumet Ramulus Evodiae 28mg, Folium Stenolomatis 18mg, Flos Eragrostinis cilianensis 18mg, Calyx seu Fructus physalis 18mg, Folium Litchi 28mg, Ipomoea pescaprae(L.) Sweet 8.0mg, Flos Salicis Babylonicae 8.0mg, Herba humuli scandentis 8.0mg, Discolia vittifrons Sch. 4.0mg, Cortex Biotae Radicis 8.0mg, Fructus Cucumidis sativi 28mg, Fructus Citri Limoniae 28mg;
Invention formulation is that the preparation method of abrasive cleaner is as follows:
1) by formula proportion, Fructus Cucumidis sativi, Fructus Citri Limoniae are added water and distill, collect distillate 200ml for subsequent use;
2) by formula proportion by Folium ailanthi, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., the Cortex Biotae Radicis removal of impurity, remove putrefaction, after soaking 30 minutes, add the water of quintuple, slow fire boiling 2 hours, boil and carry twice, get supernatant for subsequent use;
3) by method 2) supernatant and method 1) the 200ml distillate collected is combined, dilution regulates pH value, and subpackage, sterilizing, namely obtains Traditional Chinese medicinal abrasive cleaner of the present invention.
animal local excitation is tested:
The allergic reaction on guinea pigs of suppository of the present invention.Result shows: skin anaphylactic test, high dose group 0.8g (medicine)/kg, low dose group 0.1g (medicine)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicine)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicine)/kg, low dose group 3.2g (medicine)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
embodiment 5, formula:
Folium ailanthi 20mg, mentha leave 30mg, Folium Aloe 30mg, Foliumet Ramulus Evodiae 30mg, Folium Stenolomatis 20mg, Flos Eragrostinis cilianensis 20mg, Calyx seu Fructus physalis 20mg, Folium Litchi 30mg, Ipomoea pescaprae(L.) Sweet 10mg, Flos Salicis Babylonicae 10mg, Herba humuli scandentis 10mg, Discolia vittifrons Sch. 5.0mg, Cortex Biotae Radicis 10mg, Fructus Cucumidis sativi 30mg, Fructus Citri Limoniae 30mg;
Invention formulation is that the preparation method of unguentum is as follows:
Folium ailanthi is got by formula proportion, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., Cortex Biotae Radicis, Fructus Cucumidis sativi, Fructus Citri Limoniae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stir after leaving standstill, again through cold preservation, flatten, sterilization packaging technology.
animal local excitation is tested:
The allergic reaction on guinea pigs of suppository of the present invention.Result shows: skin anaphylactic test, high dose group 0.8g (medicine)/kg, low dose group 0.1g (medicine)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicine)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicine)/kg, low dose group 3.2g (medicine)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
Preparation method is identical with embodiment 1.
beneficial effect of the present invention:
First fundamentally start with, remove steam, dehumidifying completely; Secondly, kill and eliminate the fungus below epiderm skin, make the eczema phenomenon of the positions of disease such as cheek be eased and eliminate, thus make patient reach the object of rehabilitation, because being conducive to the performance of the physiological function of skin; Existing therapeutical effect, has again the effect of protection skin, decrease the drying of skin, tension, and zest is little in use procedure, and infant is easy to accept, and has a extensive future.
drug effect is evaluated:
The Chinese medicine for the treatment of infantile eczema of the present invention uses 300 routine infant disease patients clinically, is 100% through statistical confirmation effective percentage, cure rate 100%, and under therapeutic dose, Clinical practice had not found poison pair and anaphylaxis.
model case:
Case 1:
Man, 2 months, face played red eczema, pustule 1 month, and forehead, cheeks are work.Make a definite diagnosis: typical infantile eczema.Adopt liniment external of the present invention, every day 3 times.After 1 week, pustule disappears, and eczema reduces; Within 2 weeks, pimple all disappears.
Case 2:
Female, 2 months, just arises from two cheeks, erythematous papules occurs, appears because acute scratch caused by itch is grabbed the scarlet rotten to the corn face having volume sepage.Diagnosis: infantile eczema, adopts liniment external of the present invention, every day 3 times.After 1 week, erythra obviously reduces, and within 2 weeks, major part disappears, recovery from illness in 3 weeks.
Case 3:
1 month, the patch that face is pale red, with a small amount of desquamation; Make a definite diagnosis: typical infantile eczema initial symptoms, adopts unguentum external of the present invention, every day 3 times.Recover normal after 1 week.
Case 4:
There is red measles, pustule in face, makes a definite diagnosis: infantile eczema, adopt liniment external of the present invention, every day 3 times, and after 1 week, pustule disappears, and eczema reduces; Within 3 weeks, eczema all disappears.
Claims (5)
1. treat a Chinese medicine composition for infantile eczema, it is characterized in that: be that the raw material of joining part by following weight is made:
Folium ailanthi 10-20 part, mentha leave 20-30 part, Folium Aloe 20-30 part, Foliumet Ramulus Evodiae 20-30 part, Folium Stenolomatis 10-20 part, Flos Eragrostinis cilianensis 10-20 part, Calyx seu Fructus physalis 10-20 part, Folium Litchi 20-30 part, Ipomoea pescaprae(L.) Sweet 1.0-10 part, Flos Salicis Babylonicae 1.0-10 part, Herba humuli scandentis 1.0-10 part, Discolia vittifrons Sch. 0.1-5.0 part, Cortex Biotae Radicis 1.0-10 part, Fructus Cucumidis sativi 20-30 part, Fructus Citri Limoniae 20-30 part.
2. a kind of Chinese medicine composition for the treatment of infantile eczema according to claim 1, is characterized in that: be that the raw material of joining part by following weight is made:
Folium ailanthi 12-18 part, mentha leave 22-28 part, Folium Aloe 22-28 part, Foliumet Ramulus Evodiae 22-28 part, Folium Stenolomatis 12-18 part, Flos Eragrostinis cilianensis 12-18 part, Calyx seu Fructus physalis 12-18 part, Folium Litchi 22-28 part, Ipomoea pescaprae(L.) Sweet 2.0-8.0 part, Flos Salicis Babylonicae 2.0-8.0 part, Herba humuli scandentis 2.0-8.0 part, Discolia vittifrons Sch. 1.0-4.0 part, Cortex Biotae Radicis 2.0-8.0 part, Fructus Cucumidis sativi 22-28 part, Fructus Citri Limoniae 22-28 part.
3. a kind of Chinese medicine composition for the treatment of infantile eczema according to claim 1, is characterized in that: be that the raw material of joining part by following weight is made:
Folium ailanthi 15 parts, mentha leave 25 parts, Folium Aloe 25 parts, Foliumet Ramulus Evodiae 25 parts, Folium Stenolomatis 15 parts, Flos Eragrostinis cilianensis 15 parts, Calyx seu Fructus physalis 15 parts, Folium Litchi 25 parts, Ipomoea pescaprae(L.) Sweet 5.0 parts, Flos Salicis Babylonicae 5.0 parts, Herba humuli scandentis 5.0 parts, Discolia vittifrons Sch. 2.5 parts, Cortex Biotae Radicis 5.0 parts, Fructus Cucumidis sativi 25 parts, 25 parts, Fructus Citri Limoniae.
4. a kind of Chinese medicine composition for the treatment of infantile eczema according to claim 1-3 any one, is characterized in that: invention formulation is that the preparation method of unguentum is as follows:
Folium ailanthi is got by formula proportion, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., Cortex Biotae Radicis, Fructus Cucumidis sativi, Fructus Citri Limoniae adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heat is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stir after leaving standstill, again through cold preservation, flatten, sterilization packaging technology.
5. a kind of Chinese medicine composition for the treatment of infantile eczema according to claim 1-3 any one, is characterized in that: invention formulation is that the preparation method of abrasive cleaner is as follows:
1) by formula proportion, Fructus Cucumidis sativi, Fructus Citri Limoniae are added water and distill, collect distillate 200ml for subsequent use;
2) by formula proportion by Folium ailanthi, mentha leave, Folium Aloe, Foliumet Ramulus Evodiae, Folium Stenolomatis, Flos Eragrostinis cilianensis, Calyx seu Fructus physalis, Folium Litchi, Ipomoea pescaprae(L.) Sweet, Flos Salicis Babylonicae, Herba humuli scandentis, Discolia vittifrons Sch., the Cortex Biotae Radicis removal of impurity, remove putrefaction, after soaking 30 minutes, add the water of quintuple, slow fire boiling 2 hours, boil and carry twice, get supernatant for subsequent use;
3) by method 2) supernatant and method 1) the 200ml distillate collected is combined, dilution regulates pH value, and subpackage, sterilizing, namely obtains Traditional Chinese medicinal abrasive cleaner of the present invention.
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| CN105902699A (en) * | 2016-05-07 | 2016-08-31 | 刘茂花 | Traditional Chinese medicine external lotion for treating infantile eczema |
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