CN112972355A - Traditional Chinese medicine toothpaste and preparation method thereof - Google Patents
Traditional Chinese medicine toothpaste and preparation method thereof Download PDFInfo
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- CN112972355A CN112972355A CN202110221905.1A CN202110221905A CN112972355A CN 112972355 A CN112972355 A CN 112972355A CN 202110221905 A CN202110221905 A CN 202110221905A CN 112972355 A CN112972355 A CN 112972355A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a traditional Chinese medicine toothpaste and a preparation method thereof, wherein the traditional Chinese medicine toothpaste comprises the following raw materials in parts by weight: 21-26 parts of bletilla striata, 16-19 parts of radix sophorae flavescentis, 13-17 parts of an abrasive agent, 13-15 parts of liquorice, 5-9 parts of tea polyphenol, 10-13 parts of xanthan gum, 12-15 parts of glycerol, 1-2 parts of mint, 5-9 parts of honeysuckle, 0.5-1 part of spice, 0.1-0.4 part of sodium benzoate, 4-6 parts of pseudo-ginseng and 0.5-1.5 parts of sodium dodecyl sulfate. The traditional Chinese medicine toothpaste disclosed by the invention contains the medicinal materials of bletilla striata, sophora flavescens, liquorice, mint, honeysuckle and pseudo-ginseng, helps to improve gingival bleeding and gingival swelling and pain and helps to repair red and swollen parts of gingival inflammation, can effectively solve multiple oral problems of oral cavity inflammation, gingival swelling and pain, oral ulcer and the like, can comprehensively maintain the oral cavity, relieve the trouble of tooth and gingival pain, enable the oral cavity environment to be healthier and has a good antibacterial effect.
Description
Technical Field
The invention relates to the technical field of dental products, in particular to traditional Chinese medicine toothpaste and a preparation method thereof.
Background
With the enhancement of health consciousness and the improvement of life quality of people, the demand of the functional toothpaste is higher and higher. The functional toothpaste is toothpaste which is added with functional components and has the functions of bacteriostasis, anti-inflammation, antianaphylaxis, hemostasis, analgesia and the like besides the basic functions of toothpaste. Among them, the Chinese medicinal toothpaste is popular because of containing safe and effective natural plant extracts. The traditional Chinese medicine toothpaste is formed by adding traditional Chinese medicine components into a toothpaste matrix. The toothpaste matrix mainly comprises one or more of glycerol, sorbitol, propylene glycol or polyethylene glycol used as a wetting agent, sodium hydroxymethyl cellulose, hydroxyethyl cellulose, carrageenan or xanthan gum used as an adhesive singly or in combination, sodium dodecyl sulfate used as a surfactant, calcium carbonate, aluminum hydroxide, silicon dioxide or calcium bicarbonate used as an abrasive singly or in combination, essence and deionized water.
The traditional Chinese medicine toothpaste not only has the function of cleaning and beautifying teeth, but also has the more important that in the process of brushing teeth of patients, the effective components of the medicine contained in the toothpaste can form high medicine concentration in the oral cavity to exert curative effect to achieve therapeutic effect, and the toothpaste can inhibit harmful bacteria in the oral cavity and prevent and treat oral diseases. The effective components of the traditional Chinese medicine dissolved in saliva can rapidly permeate, diffuse and absorb through oral mucosa, sublingual capillary vessels and channels and collaterals and acupuncture points, and directly enter into systemic circulation to achieve the purpose of preventing and treating diseases.
The existing traditional Chinese medicine toothpaste reports that: cordyceps militaris toothpaste (CN201410281371.1, publication No. CN104068398A) and radix scutellariae tooth health product (CN200810029903.7, publication No. CN 101357154A) disclose a Chinese herbal medicine composition with antibacterial, anti-inflammatory and hemostatic effects, the active components of the composition and the weight part ratio thereof are that honeysuckle flower 1-80, radix scutellariae 1-80, radix notoginseng 0.5-40, toothpaste containing radix notoginseng extract (CN200710065739.0, publication No. CN101023914A), tea polyphenol toothpaste (CN201110042475.3, publication No. CN102106802A) and the like, the andrographis has antibacterial and anti-inflammatory effects, the radix notoginseng has obvious effects on gingival bleeding and oral ulcer, the tea polyphenol is widely applied in treating diseases such as oral caries, halitosis, periodontitis and oral mucosa canceration, and the patent products have single raw material using effects, strong efficacy limitation and weak comprehensive effects.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine toothpaste and a preparation method thereof, wherein the toothpaste has a comprehensive effect, can help improve gingival bleeding and gingival swelling and pain, help repair inflamed parts of gingiva, effectively solve multiple oral problems such as oral cavity inflammation, gingival swelling and pain, oral ulcer and the like, comprehensively maintain the oral cavity, relieve the trouble of tooth and gingival pain, make the oral environment healthier, and have a good antibacterial effect.
The adopted technical scheme is as follows:
the invention relates to a traditional Chinese medicine toothpaste which is prepared from the following raw materials in parts by weight:
further, the spice is one or two of peppermint oil and mango essence.
Further, the abrasive is one or two of calcium carbonate and calcium hydrophosphate.
The preparation method of the traditional Chinese medicine toothpaste in the scheme comprises the following steps:
s1, respectively crushing bletilla striata, sophora flavescens, liquorice, mint, honeysuckle and pseudo-ginseng, screening by a 20-60-mesh screening device, respectively and sequentially adding the crushed medicinal materials into a reaction kettle according to a weight ratio, stirring and mixing, simultaneously adding deionized water according to the weight ratio of 1:2-3 of the raw materials to the deionized water, heating to 70-80 ℃ after adding the deionized water, and continuously heating for 1-2 hours to extract;
s2, filtering by using 200-mesh and 300-mesh filter cloth after extraction is finished, and performing vacuum concentration after filtering to obtain an extract;
s3, adding the extract obtained in the step S2, an abrasive, tea polyphenol, xanthan gum, glycerol, spice and sodium benzoate into a reaction kettle in sequence, fully stirring at the stirring speed of 1500-. The prepared traditional Chinese medicine toothpaste is further subjected to aseptic filling and packaging.
In the above-mentioned technical solution,
bletilla has the effects of astringing to stop bleeding, eliminating swelling and promoting granulation.
The sophora flavescens has the effects of clearing heat and drying dampness, and has obvious inhibition effect on dysentery bacillus, escherichia coli, proteus, streptococcus B and staphylococcus aureus.
The liquorice has the functions of clearing away heat and toxic materials and harmonizing the drug properties, and the liquorice can be added to harmonize all the components.
The herba Menthae has heat and toxic materials clearing away effects, and can be used for relieving oral cavity inflammation.
The honeysuckle has the effects of resisting bacteria and diminishing inflammation, and has the effects of helping to relieve gum problems, repairing mucosa injury, nourishing gum and improving periodontal health by increasing the function of preventing dental caries.
The notoginseng contains notoginseng total saponin, which has definite anti-inflammatory and analgesic effects, and the main hemostatic component is notoginseng essence. Proved by pharmacodynamic experiments and clinical experiments, the natural nursing toothpaste containing the pseudo-ginseng extract has obvious curative effects on gingivitis, gingival bleeding, oral ulcer and the like.
Tea polyphenol is a high-efficiency low-toxicity free radical scavenger and a natural antioxidant extracted from green tea, is a natural bacteriostatic agent, and is gradually paid attention to the application of the tea polyphenol in oral diseases at present. Experimental research results show that the tea polyphenol has good oxidation resistance and obvious free radical scavenging capacity, and is widely applied to treatment of diseases such as oral caries, halitosis, periodontitis and oral mucosa canceration.
Xanthan gum is used as a bonding agent, and sodium dodecyl sulfate is used as a foaming agent.
The invention has the beneficial effects that:
(1) the traditional Chinese medicine toothpaste disclosed by the invention contains the medicinal materials of bletilla striata, sophora flavescens, liquorice, mint, honeysuckle and pseudo-ginseng, helps to improve gingival bleeding and gingival swelling and pain and helps to repair red and swollen parts of gingival inflammation, can effectively solve multiple oral problems of oral cavity inflammation, gingival swelling and pain, oral ulcer and the like, can comprehensively maintain the oral cavity, relieve the trouble of tooth and gingival pain, enable the oral cavity environment to be healthier and has a good antibacterial effect.
(2) The traditional Chinese medicine toothpaste provided by the invention has no toxic or side effect on a human body, is safe and reliable to use, has no stimulation to oral mucosa, does not generate drug resistance, and is suitable for long-term use.
Detailed Description
The present invention is described in detail below with reference to specific examples, but the use and purpose of these exemplary embodiments are merely to exemplify the present invention, and do not set forth any limitation on the actual scope of the present invention in any form, and the scope of the present invention is not limited thereto.
The examples do not specify particular techniques or conditions, and are performed according to the techniques or conditions described in the literature in the art or according to the product specifications. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
The components of the following examples and comparative examples are contained in parts by weight unless otherwise specified.
Example 1
The traditional Chinese medicine toothpaste comprises the following raw materials in parts by weight:
the spice is oleum Menthae Dementholatum and fructus Mangifera Indicae essence.
The abrasive is calcium carbonate and calcium hydrogen phosphate.
The preparation method of the traditional Chinese medicine toothpaste comprises the following steps:
s1, respectively crushing bletilla striata, sophora flavescens, liquorice, mint, honeysuckle and pseudo-ginseng, screening by a 20-60-mesh screening device, respectively and sequentially adding the crushed medicinal materials into a reaction kettle according to a weight ratio, stirring and mixing, simultaneously adding deionized water according to the weight ratio of 1:2-3 of the raw materials to the deionized water, heating to 70-80 ℃ after adding the deionized water, and continuously heating for 1-2 hours to extract;
s2, filtering by using 200-mesh and 300-mesh filter cloth after extraction is finished, and performing vacuum concentration after filtering to obtain an extract;
s3, adding the extract obtained in the step S2, an abrasive, tea polyphenol, xanthan gum, glycerol, spice and sodium benzoate into a reaction kettle in sequence, fully stirring at the stirring speed of 1500-. The prepared traditional Chinese medicine toothpaste is further subjected to aseptic filling and packaging.
Example 2
Referring to example 1, the difference from example 1 is that the traditional Chinese medicine toothpaste of this example is composed of the following raw materials by weight:
example 3
Referring to example 1, the difference from example 1 is that the traditional Chinese medicine toothpaste of this example is composed of the following raw materials by weight:
comparative example 1
Referring to example 2, unlike example 2, the present comparative example did not add bletilla, sophora flavescens, licorice, mint, honeysuckle and notoginseng.
Comparative example 2
Referring to example 2, unlike example 2, this comparative example does not add licorice.
Comparative example 3
Referring to example 2, unlike example 2, this comparative example does not add honeysuckle.
Comparative example 4
Referring to example 2, this comparative example does not add pseudo-ginseng, unlike example 2.
Comparative example 5
Referring to example 2, this comparative example does not add sophora flavescens, unlike example 2.
Test and test:
test 1
The traditional Chinese medicine toothpaste of examples 1-3 was placed in a 60 ℃ oven and stored for 4 months, after which the toothpaste was cut open and the change of the toothpaste was observed.
The toothpaste samples of examples 1-3 were stored in a shelf test at room temperature, taken out after 12 months, cut open the toothpaste and observed for changes in the toothpaste.
The microbial indicators were tested according to the technical Specification for cosmetic safety.
And (3) test results:
the toothpaste of examples 1-3 was stored at 60 ℃ for 4 months and at room temperature for 12 months, and the paste was stable, had a normal flavor and color, and did not have abnormal conditions such as paste overflowing from the toothpaste tube and liquid separation. The microbial indexes all accord with the national standard GB/T8372-2018, which shows that the traditional Chinese medicine toothpaste has good stability and the compatibility of the traditional Chinese medicine and the paste is good.
Test 2
Selecting 140 subjects to participate in the test, and photographing oral gums of the subjects; the groups were divided on average into example 1 group, example 2 group, example 3 group, comparative example 1 group, comparative example 2 group, comparative example 3 group, and comparative example 4 group, each of which was 20 persons.
The subjects brushed their teeth 1 time each day in the morning and evening for 3 minutes each time for 1 week. All the subjects in each group can not use other oral cleaning products in the test period, the oral gum of the subjects is photographed after 1 week, and the effects before and after use are compared.
The test results are shown in table 1:
TABLE 1
As can be seen from table 1, the oral gingival inflammation of the subjects in examples 1, 2 and 3 is obviously recovered faster than the oral gingival inflammation of the subjects in the comparative examples 1 to 4, and the recovery effect is obvious, which indicates that the toothpaste added with the traditional Chinese medicine has the effect of remarkably improving gingivitis; wherein, the traditional Chinese medicine toothpaste prepared by the embodiment 1, the embodiment 2 and the embodiment 3 of the invention has more remarkable effect than the traditional Chinese medicine toothpaste prepared by the comparative examples 1 to 4.
Test 3
140 subjects were selected to participate in the test and were equally divided into example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, each of which was 20 persons.
The subjects brushed their teeth 1 time and 3 minutes per time in the morning and evening for 1 week continuously, and no other oral cleaning products were used in the test period of each group of subjects, and the subjects were scored according to the degree of tooth bleeding, classified into 6 grades and scored: bleeding is not caused for 5 points, mild microhemorrhage is caused for 4 points, moderate microhemorrhage is caused for 3 points, obvious bleeding is caused for 2 points, moderate bleeding is caused for 1 point, and severe bleeding is caused for 0 point, and the gingival bleeding rate on the 2 nd day, the 4 th day, the 6 th day and the 8 th day is calculated respectively. Wherein, the calculation formula of the gingival hemostasis rate is as follows:
the gingival bleeding stopping rate is the total score of the observation on the day/the total score is multiplied by 100 percent
The test results are shown in table 2:
TABLE 2
As can be seen from Table 2, the oral gingival bleeding stopping rates of the subjects in the example 1 group, the example 2 group and the example 3 group are obviously more effective than those in the comparative examples 1-4 group, which shows that the toothpaste added with the traditional Chinese medicine can obviously improve the gingival bleeding phenomenon. In examples 2 to 4, one less Chinese medicine is used, and the effect is obviously reduced.
Test 4
Examples 1 to 3 and comparative example 5 were each tested for their bacteriostatic activity against e.coli e.coliatcc25922 and s.aureus ATCC25923 by the bacteriostatic circle method. The results are shown in Table 3.
TABLE 3
Note: the data in the table show the diameter of the zone of inhibition (diameter of the filter paper sheet 12.80mm)
The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.
Claims (4)
1. The traditional Chinese medicine toothpaste is characterized by comprising the following raw materials in parts by weight:
2. the traditional Chinese medicine toothpaste according to claim 1, wherein the spice is one or two of peppermint oil and mango essence.
3. The traditional Chinese medicine toothpaste according to claim 1, wherein the abrasive is one or both of calcium carbonate and calcium hydrogen phosphate.
4. A method for preparing a traditional Chinese medicine toothpaste as claimed in any one of claims 1 to 3, comprising the steps of:
s1, respectively crushing bletilla striata, sophora flavescens, liquorice, mint, honeysuckle and pseudo-ginseng, screening by a 20-60-mesh screening device, respectively and sequentially adding the crushed medicinal materials into a reaction kettle according to a weight ratio, stirring and mixing, simultaneously adding deionized water according to the weight ratio of 1:2-3 of the raw materials to the deionized water, heating to 70-80 ℃ after adding the deionized water, and continuously heating for 1-2 hours to extract;
s2, filtering by using 200-mesh and 300-mesh filter cloth after extraction is finished, and performing vacuum concentration after filtering to obtain an extract;
s3, adding the extract obtained in the step S2, an abrasive, tea polyphenol, xanthan gum, glycerol, spice and sodium benzoate into a reaction kettle in sequence, fully stirring at the stirring speed of 1500-.
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| CN118217207A (en) * | 2024-05-23 | 2024-06-21 | 广州舒客实业有限公司 | Hemostatic and anti-inflammatory toothpaste and preparation method and application thereof |
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| CN118217207A (en) * | 2024-05-23 | 2024-06-21 | 广州舒客实业有限公司 | Hemostatic and anti-inflammatory toothpaste and preparation method and application thereof |
| CN118217207B (en) * | 2024-05-23 | 2024-09-17 | 广州舒客实业有限公司 | Hemostatic and anti-inflammatory toothpaste and preparation method and application thereof |
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