CN101708152B

CN101708152B - Medicated toothpaste

Info

Publication number: CN101708152B
Application number: CN 200910308821
Authority: CN
Inventors: 蒋才武; 覃青云; 黄光伟; 陈毅飞; 卢凯玲; 黄晓燕
Original assignee: LIUZHOU LMZ CO Ltd
Current assignee: LIUZHOU LMZ CO Ltd
Priority date: 2009-10-26
Filing date: 2009-10-26
Publication date: 2013-03-27
Anticipated expiration: 2029-10-26
Also published as: CN101708152A

Abstract

The invention discloses medicated toothpaste. Lanzhi which has the functions of resisting inflammation, stopping bleeding and relieving pain is contained in the toothpaste body, wherein the lanzhi is formed by mixing a shanfeng extract and a screwtree root extract. Compared with the traditional medicated toothpaste, the medicated toothpaste not only has the obvious functions of diminishing inflammation, stopping bleeding and relieving pain but also has the characteristics of safe use, extensive source of medicinal materials and low cost of raw materials.

Description

Medicated toothpaste

Technical field

The present invention relates to a kind of toothpaste with Chinese medicine auxiliary therapeutic action.

Background technology

Periodontal is common oral disease, and its symptom mainly contains gingival hemorrhage, swelling, pain.There is statistics to show that periodontal is the main cause of crowd's absence of tooth more than 35 years old, the seriousness of visible periodontal.But because the patient is difficult for discovering, most people does not also know oneself to suffer from this disease.Many human factor errors ground think the people to old age just can suffer from periodontal, in fact 5 years old child just can suffer from gingivitis.

Periodontal disease is not only the health that affects tooth, also can systemic health.Periodontal disease has caused people's concern on the impact of whole body health in recent years.Antibacterial composition and bacterial product are easy to be diffused into neighbouring or be far apart organ by the periodontal pocket ulcer surface, cause or aggravate some general disease, such as the genesis of the diseases such as coronary heart disease, low birth weight infant, diabetes, pulmonary infection, serious harm health.Depend merely on stomatological hospital and Drug therapy and be and can't satisfy the needs that people improve the oral health level, be used the oral cavity nursing health products with control periodontal, periodontal can progressively effectively be prevented and be controlled.

Existing medicated toothpaste such as Yunnan BAIYAO toothpaste with antiinflammatory, hemostasis, analgesic activity, the pseudo-ginseng distributional region of the main composition that adopts is few, and growth cycle is long and price is high.

Summary of the invention

The problem that the present invention solves provides a kind ofly not only has obvious antiinflammatory, hemostasis, analgesic activity, and the raw material of its active constituents of medicine come former wide, the medicated toothpaste of low cost of manufacture.

In the mastic of medicated toothpaste of the present invention, ancillary drug raw material as antiinflammatory, hemostasis and analgesic activity is compositions haze sesame, this haze sesame accounts for 0.1～5.0% of described mastic percentage by weight, described haze sesame is to be combined into by the extract of Chinese medicine mountain breeze and the extract mixture of Radix Helicteris, and the former medicine ratio that forms these two kinds of Chinese medicines of described haze sesame is mountain breeze: Radix Helicteris=1:2.

In such scheme, described mountain breeze extract generally is the xeraphium of mountain breeze ethanol extraction, and described Radix Helicteris extract is the xeraphium of Radix Helicteris ethanol extraction.

Strong medicine mountain breeze, the Latin literary fame: Blumea aromatica DC is the dry herb of Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae, plant name fragrance virtue Herba Blumeae Balsamiferae, nature and flavor suffering, little hardship, temperature can promoting blood circulation and detumescence, among the peoplely in the Zhuang area are used for treating the diseases such as rheumatic arthralgia, traumatic hemorrhage.Its detumescence effect of invigorating blood circulation is just meeting strong doctor's regulating QI, detoxifcation, the Therapeutic Principle of tonify deficiency.

Radix Helicteris, the Latin literary fame: Helicters angustifolia L, be the dry herb of Sterculiaceae Radix Helicteris platymiscium Radix Helicteris, bitter, little sweet, cold.Heat-clearing and toxic substances removing, cough-relieving.Be used for cold and high fever, tonsillitis, pharyngolaryngitis, parotitis, measles, cough, malaria; Venom is controlled in external, traumatic hemorrhage, hemorrhoid, carbuncle furuncle.

This medicated toothpaste has added the raw material of compositions haze sesame as the natural medicinal plants active component, not only has antiinflammatory, hemostasis, analgesic activity, uses the effect of safety, and this medicine material wide material sources, and its cost only is the 2-10% of pseudo-ginseng.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Among following each embodiment, related percentage ratio all is to calculate by weight percentage except as otherwise noted.

Each constitutive material and weight percent content among table 1: the embodiment 1 to embodiment 4

Preparation method:

In above-described embodiment, lotion of toothpaste can adopt the dry method of conventional medicine toothpaste cream production technology processed to make: determined the once total amount of preparation by the capacity of production equipment, total amount according to once preparation is obtained each raw material according to the cubage of above-listed each constitutive material, dropping into the pure water, the wetting agent that measure in temporary cylinder (is the sorbitol among the embodiment 1, sorbitol among the embodiment 2,4 and glycerol, the sorbitol among the embodiment 3,5 and propylene glycol) etc. liquid material; In pre-dispersed still, drop into the haze sesame that measures, abrasive (is the calcite in powder among the embodiment 1, silicon dioxide among the embodiment 3, embodiment 2, calcium hydrogen phosphate powder and silicon dioxide powder in 4), sweeting agent (being the saccharin sodium among the embodiment 1 to 5), thickening agent (is the sodium carboxymethyl cellulose among the embodiment 1, embodiment 2, sodium carboxymethyl cellulose in 4 and carrageenan, embodiment 3, sodium carboxymethyl cellulose in 5 and guar gum), foaming agent (being the sodium lauryl sulphate among the embodiment 1 to 5), sodium benzoate, tetrasodium pyrophosphates etc. carry out pre-dispersed, mix; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, advance above-mentioned powder, drive agitator and colloid mill, drop into essence after 50 minutes, close successively colloid mill, agitator, scraper after 10 minutes, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.

Haze sesame in the example is comprised of in the 1:2 ratio mountain breeze ethanol extraction xeraphium and Radix Helicteris ethanol extraction xeraphium, being equivalent to the former medicine of mountain breeze is 1:2 with the former medicine ratio of Radix Helicteris, in the mastic preparation section, that haze sesame and other powder of toothpaste carry out first is pre-dispersed, mix.

The xeraphium of the mountain breeze ethanol extraction in the haze sesame and the xeraphium of Radix Helicteris ethanol extraction all are after its crude drug is obtained ethanol extraction take ethanol as solvent through conventional ethanol extraction method, and Recycled ethanol also carries out drying acquisition to extract.Conventional ethanol extraction method has: cold-maceration, percolation, circumfluence method, supersound extraction etc.

Antiinflammatory of the present invention, hemostasis and analgesic activity mainly are to determine according to the content of haze sesame in mastic, the too small effect that can affect auxiliary treatment of its content, content is crossed conference and is caused waste, and can not affect safety to human body, toothpaste with the embodiment of haze sesame content minimum is tested, and the result is as follows:

The experiment that animal white mice auricle acute inflammation swelling antiinflammatory carries out due to the xylol that the antiinflammatory action experiment is is made simultaneously positive control and blank and is observed.Experimental result shows, this medicated toothpaste and positive control add the toothpaste of 0.03% YUNNAN BAIYAO, compare with the blank group, all xylol is caused the swelling of laboratory animal white mice auricle acute inflammation obvious antiinflammatory action is arranged, there were significant differences statistically, shows that this compositions haze sesame toothpaste has significant antiinflammatory action.

Choose 60 of 20g left and right sides male and healthy white mice, be divided at random 3 groups, be respectively blank group (the positive group of toothpaste matrix group) ﹑ (each 20 of 0.03% YUNNAN BAIYAO toothpaste) ﹑ medicine groups.Be coated with dimethylbenzene 0.02ml/ in the mouse right ear two sides only, behind the 30min, only be applied to the about 1g/ of corresponding medicated toothpaste at auris dextra respectively, take off cervical vertebra behind the coating behind the 1h and put to death mice, clean medicine that ear is coated with, cut two ears along the auricle baseline, sweep away the disk at the same position of left and right two ears with the 9mm card punch, weigh in analytical balance.Deducting left auricle weight with auris dextra sheet weight is swelling, and the antiinflammatory action of comparative drug calculates inhibitory rate of intumesce:

As shown in Table 1, for the mice auricle swelling degree, the difference between blank group and positive group, the medicine group has significant (P＜0.05).Difference between positive group and the medicine group does not have significant (P〉0.05).

Table 1: the impact of xylol induced mice ear swelling (

± s)

*: compare with the toothpaste matrix group: P＜0.05, △: and YUNNAN BAIYAO toothpaste group is relatively: P〉0.05.

The analgesic activity test is to cause the analgesic activity experiment that experiment white mice writhing response carries out with Dichlorodiphenyl Acetate of the present invention, makes simultaneously positive control and blank and observes.Experimental result shows, this medicated toothpaste and positive control add the toothpaste of 0.03% YUNNAN BAIYAO, compare with the blank group, all Dichlorodiphenyl Acetate causes that experiment white mice writhing response has obvious analgesic activity, there were significant differences statistically, shows that this compositions haze sesame toothpaste has significant analgesic activity.

Choose 60 of 20g left and right sides male and healthy white mice, be divided at random 3 groups, be respectively blank group (the positive group of toothpaste matrix group) ﹑ (each 20 of 0.03% YUNNAN BAIYAO toothpaste) ﹑ medicine groups.Abdominal part is shaved hair, and (behind 24 h of 2 cm * 2cm), each group only is applied to each mouse part skin with the about 1g/ of different pharmaceutical toothpaste, and behind the administration 30min, the glacial acetic acid solution 0.2ml of every equal ip0.6% observes writhing number of times in the 15min, calculating analgesia rate.

As shown in Table 2, for the writhing number of times in the mice 15min, the difference between blank group and positive group, the medicine group has significant (P＜0.05).Difference between positive group and the medicine group does not have significant (P〉0.05).

Table 2: on the impact of writhing method induced mice writhing number of times (

± s)

The anastalsis test is with this medicated toothpaste mechanical damage to be caused the hemorrhage hemostasis experiment of being done of experiment Liver of Mice, makes simultaneously positive control and blank and observes.Experimental result shows, this compositions haze sesame toothpaste and positive control add the toothpaste of 0.03% YUNNAN BAIYAO, compare with the blank group, all mechanical damage is caused that the experiment Liver of Mice is hemorrhage to have a significant anastalsis, there were significant differences statistically, shows that this compositions haze sesame toothpaste has significant anastalsis.

Choose 60 of 20g left and right sides male and healthy white mice, be divided at random 3 groups, be respectively blank group (the positive group of toothpaste matrix group) ﹑ (each 20 of 0.03% YUNNAN BAIYAO toothpaste) ﹑ medicine groups.Every equal ip30% urethane solution 0.2ml is anaesthetized, get liver, cut off the long wound of 1cm with the operation curved scissors, gauze is coated with the about 1g/ of a different pharmaceutical toothpaste external application, and beginning timing, every 30s observes once,, calculates the bleeding time (3min that presses that the bleeding time surpasses 3min calculates) until wound blood is no longer excessive.

As shown in Table 3, for mouse liver external application bleeding stopping period, the difference between blank group and positive group, the medicine group has significant (P＜0.05).Difference between positive group and the medicine group does not have significant (P〉0.05).

Table 3: on the impact of mice local hemorrhage bleeding stopping period (

± s)

Compositions haze sesame of the present invention can add in the oral cavity nursing health products such as existing common collutory, dentifrice, throat lozenge, chewing gum the ancillary drug raw material as antiinflammatory, hemostasis, analgesic activity equally.

Claims

1. medicated toothpaste, it is characterized in that: including percentage by weight in the lotion of toothpaste is 0.1～5.0%, be used as the haze sesame of antiinflammatory, hemostasis and analgesic activity, described haze sesame is mixed by mountain breeze extract and Radix Helicteris extract and forms, described mountain breeze extract is the xeraphium of mountain breeze ethanol extraction, described Radix Helicteris extract is the xeraphium of Radix Helicteris ethanol extraction, and the ratio of the xeraphium of the xeraphium of described mountain breeze ethanol extraction and described Radix Helicteris ethanol extraction is 1:2.